FB2019_05, released Oct 15, 2019

Gene: Dmel\Gart

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General Information
Symbol
Dmel\Gart
Species
D. melanogaster
Name
GART trifunctional enzyme
Annotation Symbol
CG31628
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000053
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
Phosphoribosylglycinamide formyltransferase (2.1.2.2)
Phosphoribosylformylglycinamidine cyclo-ligase (6.3.3.1)
Phosphoribosylamine--glycine ligase (6.3.4.13)
Gene Snapshot
GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As
ade3, adenosine 3
Key Links
Genomic Location
Cytogenetic map
27D4-27D4
Sequence location
2L:7,014,623..7,023,898 [-]
Recombination map
2-24
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; phosphoribosylglycinamide formyltransferase activity
Predictions / Assertions
ATP binding; metal ion binding; phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity
Catalytic Activity (EC)
Experimental Evidence
10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide (2.1.2.2)
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole (6.3.3.1)
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide (6.3.4.13)
Predictions / Assertions
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole (6.3.3.1)
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)- (5-phospho-D-ribosyl)glycinamide (6.3.4.13)
Summaries
Gene Group (FlyBase)
CYCLO-LIGASES -
Cyclo-ligases catalyze the joining of two groups within a single molecule via a carbon-nitrogen bond, forming a heterocyclic ring.
HYDROXYMETHYL-, FORMYL- AND RELATED TRANSFERASES -
Hydroxymethyl-, formyl- and related transferases catalyze the transfer of a hydroxymethyl- or formyl group from donor compound to another acceptor.
Protein Function (UniProtKB)
Trifunctional enzyme required for de novo purine biosynthesis.
(UniProt, P00967)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
ade3 (S. Henikoff and D. Nash)
Purine nucleoside auxotroph supplementable with adenine, adenosine, and inosine. Recovery of ade3 progeny from crosses between ade3 and ade3/SM5 is about 1% when raised on minimal medium. Less than 3% of the normal activity purine de novo synthetic pathway enzyme, glycineamide ribotide transformylase [EC 2.1.2.2 (GART)]. Eye color normal.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Gart or the JBrowse view of Dmel\Gart for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gart-RA
FBtr0079431
NM_078773
4480
1353
Gart-RB
FBtr0100353
NM_001014477
1556
434
Gart-RC
FBtr0339663
NM_001298769
4718
1353
Additional Transcript Data and Comments
Reported size (kB)
4.7, 1.7 (northern blot)
(Henikoff et al., 1983)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Gart-PA
FBpp0079059
144.5
1353
7.22
NP_523497
AAF52474
Gart-PB
FBpp0099760
45.9
434
7.65
NP_001014477
AAX52661
Gart-PC
FBpp0308722
144.5
1353
7.22
NP_001285698
AHN54213
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1353 aa isoforms: Gart-PA, Gart-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
1353, 434 (aa)
(Henikoff et al., 1986)
>1296 (aa)
(Henikoff et al., 1983)
Comments
A shorter alternative form of ade3 protein which lacks the C-terminal GAR-transformylase domain.
(Henikoff et al., 1983)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gart using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (9 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
phosphoribosylamine-glycine ligase activity
inferred from mutant phenotype
(assigned by UniProt )
(Henikoff et al., 1986)
inferred from direct assay
(Henikoff et al., 1986)
phosphoribosylformylglycinamidine cyclo-ligase activity
inferred from direct assay
(Henikoff et al., 1986)
inferred from mutant phenotype
(assigned by UniProt )
(Henikoff et al., 1986)
phosphoribosylglycinamide formyltransferase activity
inferred from mutant phenotype
(assigned by UniProt )
(Henikoff et al., 1986)
inferred from direct assay
(Henikoff et al., 1986)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR011761, InterPro:IPR013815, InterPro:IPR013816
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
metal ion binding
inferred from electronic annotation with InterPro:IPR011761
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
phosphoribosylamine-glycine ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN000055158
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphoribosylformylglycinamidine cyclo-ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN000055158
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
purine nucleobase biosynthetic process
inferred from mutant phenotype
(assigned by UniProt )
(Henikoff et al., 1986)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
'de novo' IMP biosynthetic process
inferred from electronic annotation with InterPro:IPR004607, InterPro:IPR004733
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
purine nucleobase biosynthetic process
inferred by curator from GO:0004637,GO:0004641,GO:0004644
(Henikoff et al., 1986)
purine nucleotide biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000055158
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000055158
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{803.P.SVS-0}GartCPTI003733
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
adult brain

Comment: low expression throughout adult brain

(Knowles-Barley, 2011.8.24)
oogenesis
female germline cell
(Lowe et al., 2014)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gart in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gart
Transgenic constructs containing regulatory region of Gart
Deletions and Duplications ( 5 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GART
15 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gart
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Gart
11 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\gart
6 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\gart
6 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\F38B6.4
14 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\PUR2
6 of 9
Yes
Yes
Atha\PUR5
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ADE5,7
13 of 15
Yes
Yes
Scer\ADE8
2 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ade1
11 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919017N )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Gart
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001472
Drosophila simulans
Dsim\GD22518
Drosophila sechellia
Dsec\GM13655
Drosophila erecta
Dere\GG26187
Drosophila yakuba
Dyak\GE18382
Drosophila ananassae
Dana\GF14946
Drosophila pseudoobscura pseudoobscura
Dpse\ade3
Drosophila persimilis
Dper\GL25777
Drosophila willistoni
Dwil\GK14862
Drosophila virilis
Dvir\GJ13961
Drosophila mojavensis
Dmoj\GI11847
Drosophila grimshawi
Dgri\GH13636
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17011904
Glossina morsitans
Tsetse fly
Gmor\GMOY003296
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00229
Mayetiola destructor
Hessian fly
Mdes\Mdes014561
Mayetiola destructor
Hessian fly
Mdes\Mdes002884
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010640
Anopheles darlingi
American malaria mosquito
Adar\ADAC006766
Anopheles gambiae
Malaria mosquito
Agam\AGAP009786
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009144
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009145
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01T4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA014119
Bombyx mori
Silkmoth
Bmor\BGIBMGA014118
Danaus plexippus
Monarch butterfly
Dple\DPOGS206359-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017120
Apis florea
Little honeybee
Aflo\2199134340
Apis mellifera
Western honey bee
Amel\GB41233
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13960
Bombus terrestris
Buff-tailed bumblebee
Bter\15215301
Linepithema humile
Argentine ant
Lhum\LH13519
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000b76
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004793
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07026
Tribolium castaneum
Red flour beetle
Tcas\TC034834
Pediculus humanus
Human body louse
Phum\PHUM292430
Rhodnius prolixus
Kissing bug
Rpro\RPRC003183
Cimex lectularius
Bed bug
Clec\CLEC002960
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI081906
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009448
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01970
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01EH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011949
Ixodes scapularis
Black-legged tick
Isca\ISCW017017
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79800.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g04480
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G026D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gart_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gart
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gart_2
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007699
Gallus gallus
Domestic chicken
Ggal\LOC427977
Gallus gallus
Domestic chicken
Ggal\GART
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
    15 of 15
    138440
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-24
        Cytogenetic map
        27D4-27D4
        Sequence location
        2L:7,014,623..7,023,898 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        27D4-27D4
        Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        27D-27D
        (determined by in situ hybridisation)
        (Henikoff et al., 1986, Henikoff et al., 1981)
        Experimentally Determined Recombination Data
        Location
        2-24
        (FlyBase, 2016)
        2-23.2
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (11)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (87)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: Gart ade3
        (FlyBase, 2017-)
        Source for database merge of
        Additional comments
        Renamed from 'ade3' to 'Gart' (in FB2018_01) to reflect usage in the literature and provide nomenclature consistent with the clear vertebrate ortholog (and replace existing nomenclature suggesting incorrect relationships to yeast orthologs).
        (FlyBase, 2017-)
        Annotation CG8761 split into CG31628 (ade3), CG31908 in release 3 of the genome annotation.
        (FlyBase Genome Annotators, 2002-2003)
        Other Comments
        Encodes the three enzymes in the purine biosynthetic pathway, glycineamide ribotide synthetase (GARS), aminoimidazole ribotide synthetase (AIRS) and GART.
        (Lindsley and Zimm, 1992)
        Purine nucleoside auxotroph supplementable with adenine, adenosine and inosine. Recovery of ade3 progeny from crosses between ade31 and ade31/SM5 is about 1% when raised on minimal medium. Less than 3% of the normal activity purine de novo synthetic pathway enzyme, glycineamide ribotide transformylase (GART). Mutants, if viable, have a brownish eye colour and wing and bristle defects.
        (Lindsley and Zimm, 1992)
        Nucleotide excision repair of (6-4)photoproducts has been assayed in the ade3 locus of Kc (embryonic) cell line, after exposure to UV light. The ade3 locus is transcriptionally active in Kc cells, but the repair rate is the same as for the transcriptionally inactive white gene, as well as for the transcriptionally active N gene. Repair rate is enhanced with prior exposure to photoreactivating light. No strand specificity of repair is observed.
        (de Cock et al., 1992)
        Removal of UV-induced pyrimidine dimers is measured in genes ade3, N and w in two diploid immortalised cell lines (Kc and SL2) to investigate whether preferential repair forms part of DNA excision repair. Data supports the idea that preferential repair is not restricted to transcriptionally active sequences.
        (de Cock et al., 1991)
        The organization of the ade3 protein in Drosophila has multiple domains with GAR transformylase at the carboxyl terminus preceded by an extensive repeat.
        (Henikoff et al., 1983)
        Enzyme assays confirm that ade3 encodes GAR transformylase.
        (Henikoff et al., 1983)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 77 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        modMine - A data warehouse for the modENCODE project
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (15)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (99)