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Gene Dmel\agn

General Information
Symbol	Dmel\agn	Species	D. melanogaster
Name	agnostic	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0000060
Gene Model Status	Unannotated	Stock availability	None publicly available
Genomic Location
Chromosome (arm)		Recombination map	1-38.9
Cytogenetic map	11A8-11A8	Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene agnostic is referred to in FlyBase by the symbol Dmel\agn (FBgn0000060). It is a gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: oogenesis. 5 alleles are reported. The phenotype of these alleles is annotated with: nodulus. It has no annotated transcripts. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	agn: agnostic Identified as three temperature sensitive lethal mutations. Adenylate cyclase activity somewhat higher than normal at 22 and readily activated at 29. Phosphodiesterase activity assayed in heat-pretreated homogenates higher than normal. Locomotor activity decreased and learning activity increased at 22, like dnc at 29.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11A8-11A8   Left limit from (method unavailable) (FBrf0042237) Right limit from inclusion within Tp(1;2)v+65b (FBrf0042237)
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Determined by deficiency mapping (details unspecified).   (Savvateeva et al., 1985)
Experimentally Determined Recombination Data
Location	1-38.9 (Strauss and Heisenberg, 1993, Savvateeva et al., 1985, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | heat sensitive agn1 agn3 Other Phenotypes Allele learning defective agn1 agn3 learning defective | female agnX1 learning defective | heat sensitive agn1 agn2 agn3 locomotor behavior defective agn2 agn3 mitotic cell cycle defective agn1 smell perception defective | female agnX1 Phenotype manifest in Allele egg chamber | heat sensitive agn1 follicle cell | heat sensitive agn1 nodulus agnX1 nurse cell | heat sensitive agn1
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of agn Class Mutagen Stocks Known lesion agn1 ethyl methanesulfonate 0 -- agn2 ethyl methanesulfonate 0 -- agn3 ethyl methanesulfonate 0 -- agnX1 spontaneous 0 -- agnX2 spontaneous 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of agn Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Disrupted in	Df(1)v65b (Savvateeva et al., 1985)
Not disrupted in	Df(1)KA10 (Savvateeva et al., 1985)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
oogenesis inferred from genetic interaction with ct AND inferred from mutant phenotype (Jackson and Berg, 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions agn allele Gene References agn1 ct (Jackson and Berg, 1999)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000060
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 5656846
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	agn controls calmodulin properties by encoding a calmodulin-inhibiting protein. (Sharagina et al., 1997) Mutation at the agn gene results in increased PDE-1 activity. (Sharagina et al., 1997) Known from temperature sensitive lethal mutations that affect phosphodiesterase and adenyl cyclase activity, and have learning defects.
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000060 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 5656846
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	ag (Sharagina et al., 1997) agn (Jackson and Berg, 1999) l(1)11Af   ts398 (Savvateeva et al., 1985)
Name Synonym	agnostic
Secondary FlyBase IDs
References ( 15 )
Research paper	Defays and Bertoli, 2012, Alcohol 46(8): 737--745 Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. [FBrf0220080] Scholz et al., 2000, Neuron 28(1): 261--271 Functional ethanol tolerance in Drosophila. [FBrf0131396] Jackson and Berg, 1999, Genetics 153(1): 289--303 Soma-to-germline interactions during Drosophila oogenesis are influenced by dose-sensitive interactions between cut and the genes cappuccino, ovarian tumor and agnostic. [FBrf0111392] Sharagina et al., 1997, Russ. J. Genet. 33(6): 659--661 Study of cyclic nucleotide phosphodiesterase activity in mutant Drosophila melanogaster strains. [FBrf0102470] Sharagina et al., 1997, Genetika, Moscow 33(6): 784--787 [Study of cyclic nucleotide phosphodiesterase activity in mutant Drosophila melanogaster strains.] [FBrf0098348] Strauss and Heisenberg, 1993, J. Neurosci. 13(5): 1852--1861 A higher control center of locomotor behavior in the Drosophila brain. [FBrf0058917] Savvateeva et al., 1985, D. I. S. 61: 144--146 Map expansion around ts-mutations in genes controlling cAMP metabolism in D. melanogaster. [FBrf0042237] Savvateeva et al., 1985, Dev. Genet. 5(3): 157--172 Expression of adenylate cyclase and phosphodiesterase in development of temperature-sensitive mutants with impaired metabolism of cyclic AMP in Drosophila melanogaster. [FBrf0042389]
Review	Ferrus and Canal, 1994, Trends Neurosci. 17(11): 479--486 The behaving brain of a fly. [FBrf0078379]
Abstract	Savvateeva-Popova et al., 2003, Europ. Dros. Res. Conf. 18: P07 The Drosophila agnostic locus as a model for human Williams syndrome connecting chromosomal architecture and cognitive functions. [FBrf0161930] Jackson and Berg, 1999, A. Dros. Res. Conf. 40: 761A Soma-to-germline interactions are influenced by dose-sensitive interactions between cut and cappuccino, ovarian tumor and agnostic. [FBrf0106690] Jackson and Berg, 1999, Mol. Biol. Cell 10(Suppl.): 366a cut-regulated signaling during Drosophila oogenesis involves cAMP- and cytoskeleton-regulated genes. [FBrf0125313] Savvateeva et al., 1993, J. Neurogenet. 8: 247--248 Behavioral and biochemical effects of the agnostic gene mutations. [FBrf0079768] Savvateeva et al., 1991, J. Neurogenet. 7: 145 Temperature-sensitive mutations affecting cAMP metabolism in study of learning in Drosophila. [FBrf0064255]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]