ald, dMps1, altered disjunction
Gene model reviewed during 5.44
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mps1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mps1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: ald Mps1
The gene symbol "ald" has been changed to "Mps1" to reflect published usage and in order to reduce confusion with the "Ald" ("Aldolase") gene symbol, from which it differed only by case.
The rate of meiotic errors in ald mutant females is linked to an increased likelihood of premature release of sister chromatid cohesion, rather than just a shortening of prometaphase duration.
dsRNA against this gene has been used to treat SL2 cells to study the effect of depletion of ald on the spindle checkpoint.
CG31251- CG31360+ CG31249- Overall orientation not stated: CG14322+ CG7523- ald+ CG18212- CG7655+
Cytological analysis shows that ald plays a role in the maintenance of the chiasmate homolog associations during meiotic metaphase I.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, decrease in mitotic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells and spindle abnormalities are seen.
RNAi experiments in S2 cells causes no discernable phenotype. Over-expression results in cells displaying abnormal anaphases, with chromatin stretched over the central spindle.
ald is required for the mitotic spindle checkpoint and is required for the metaphase arrest that results in response to hypoxic conditions.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutant females show an increased frequency of nondisjunction of the X and 4th chromosomes.