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Gene: Dmel\Ald1

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General Information
Symbol
Dmel\Ald1
Species
D. melanogaster
Name
Aldolase 1
Annotation Symbol
CG6058
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000064
Gene Model Status
Current
Stock Availability
18 publicly available
Enzyme Name (EC)
Fructose-bisphosphate aldolase (4.1.2.13)
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
Ald
Key Links
Genomic Location
Cytogenetic map
97A6-97A6
Sequence location
3R:26,254,069..26,261,591 [-]
Recombination map
3-90
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the class I fructose-bisphosphate aldolase family. (P07764)
Protein Domains/Motifs
InterPro
Fructose-bisphosphate aldolase, class-I; Aldolase-type TIM barrel; Fructose-bisphosphate aldolase class-I active site
Molecular Function (see GO section for details)
Experimental Evidence
fructose-bisphosphate aldolase activity
Predictions / Assertions
-
Catalytic Activity (EC)
Experimental Evidence
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate (4.1.2.13)
Predictions / Assertions
-
Summaries
Gene Group Membership
ALDEHYDE-LYASES -
Aldehyde-lyases catalyze the cleavage of carbon-carbon bond in alcohols into carbanions and aldehydes. The vast majority are aldolases, involved in carbohydrate metabolism. (Adapted from FBrf0238856).
UniProt Contributed Function Data
May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).
(UniProt, P07764)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Ald: Aldolase
Structural gene for fructose-biphosphate aldolase (EC 4.1.2.13). Enzyme multimeric based on the formation of heteromultimeric bands on gels from heterozygotes for electrophoretic variants. Amino-acid sequence determined; protein is a 158-kd multimer comprising four 360-amino-acid polypeptides. Monomers show 71% identity with rabbit muscle aldolase (Malek, Suter, Frank, and Brenner-Holzach, 1985, Biochem. Biophys. Res. Comm. 126: 199-205). Mixed multimers of rabbit and Drosophila subunits able to function (Brenner-Holzach and Leuthard, 1972, Eur. J. Biochem. 31: 423-26). Sequence analysis suggests alternating domains of alpha helix and beta sheet; domain boundaries correspond to boundaries between exons as seen in rat-liver aldolase (Sawyer, Fothergill-Gilmore, and Freemont, 1988, Biochem. J. 249: 789-93).
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\Ald1 or the JBrowse view of Dmel\Ald1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.43
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.49
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ald1-RB
FBtr0084994
NM_170262
2636
361
Ald1-RC
FBtr0084995
NM_170263
1279
361
Ald1-RD
FBtr0084999
NM_170264
1483
361
Ald1-RE
FBtr0085000
NM_079791
1747
363
Ald1-RH
FBtr0085001
NM_206577
1618
363
Ald1-RI
FBtr0114544
NM_170266
1736
363
Ald1-RJ
FBtr0306657
NM_170261
1614
363
Ald1-RK
FBtr0310660
NM_170265
1472
361
Ald1-RL
FBtr0310661
NM_001276056
1615
363
Ald1-RM
FBtr0339614
NM_001300612
2102
361
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ald1-PB
FBpp0084367
39.0
361
7.49
NP_733141
AAF56579
Ald1-PC
FBpp0084368
39.0
361
7.49
NP_733142
AAN14381
Ald1-PD
FBpp0084372
39.0
361
7.49
NP_733143
AAN14382
Ald1-PE
FBpp0084373
39.6
363
7.10
NP_524515
AAN14384
Ald1-PH
FBpp0089214
39.6
363
7.87
NP_996300
AAS65220
Ald1-PI
FBpp0113036
39.6
363
7.10
NP_733145
AAN14383
Ald1-PJ
FBpp0297612
39.6
363
7.87
NP_733140
AAN14380
Ald1-PK
FBpp0302780
39.0
361
7.49
NP_733144
AAF56580
Ald1-PL
FBpp0302781
39.6
363
7.87
NP_001262985
AGB96365
Ald1-PM
FBpp0308680
39.0
361
7.49
NP_001287541
AHN57540
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

361 aa isoforms: Ald1-PB, Ald1-PC, Ald1-PD, Ald1-PK, Ald1-PM
363 aa isoforms: Ald1-PE, Ald1-PI
363 aa isoforms: Ald1-PH, Ald1-PJ, Ald1-PL
Additional Polypeptide Data and Comments
Reported size (kDa)
360 (aa)
(Malek et al., 1988)
Comments
External Data
Subunit Structure (UniProtKB)
Homotetramer.
(UniProt, P07764)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ald1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
fructose-bisphosphate aldolase activity
inferred from direct assay
(Lissemore et al., 1990)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
glucose homeostasis
inferred from mutant phenotype
(Ugrankar et al., 2015)
glycolytic process
inferred from direct assay
(Lissemore et al., 1990)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
mesoderm development
non-traceable author statement
(Furlong et al., 2001)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
M band
inferred from direct assay
(Sullivan et al., 2003)
Z disc
inferred from direct assay
(Sullivan et al., 2003)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Ald transcript levels are unaltered by dietary variations in the level of glucose, fructose, or starch. A small increase in transcript level is seen on 5% sucrose vs. 0.3% sucrose. Ald transcript levels increase slightly in response to starch.
(Lissemore et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
flight muscle
(Sullivan et al., 2003)
flight muscle
(Sullivan et al., 2003)
flight muscle
• M band
(Sullivan et al., 2003)
flight muscle
• Z disc
(Sullivan et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Glycolytic enzymes, including Gpdh protein are localized to M bands and Z discs, as visualized in the isolated myofibrils of flight muscles, where immunoreactivity appears as alternating bright and less-intense bands.
(Sullivan et al., 2003)
Ald enzyme levelsare not significantly influenced by dietary sucrose, glucose, or fructose.Activity was slightly elevated in response to starch. Ald levelsdecrease slightly on 9% ethanol compared to 1% ethanol.
(Lissemore et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
M band
inferred from direct assay
(Sullivan et al., 2003)
Z disc
inferred from direct assay
(Sullivan et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ald1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 12 )
Transgenic Constructs ( 10 )
Deletions and Duplications ( 4 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4da.PU
lethal, with Scer\GAL4Tub.PU
lethal - all die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal - all die during embryonic stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4repo.PU
viable
viable, with Scer\GAL4nSyb.PS
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
electrophoretic variant | fast
electrophoretic variant | slow
flightless, with Scer\GAL4Mef2.PR
neuroanatomy defective | adult stage, with Scer\GAL4repo-M1B
neuroanatomy defective | progressive (with Df(3R)BSC496)
neuroanatomy defective | progressive (with Df(3R)BSC512)
neuroanatomy defective | progressive (with Df(3R)Exel6204)
neuroanatomy defective | progressive | recessive
paralytic | heat sensitive (with Df(3R)BSC496)
paralytic | heat sensitive (with Df(3R)BSC512)
paralytic | heat sensitive (with Df(3R)Exel6204)
paralytic | heat sensitive (with Df(3R)Tl-P)
paralytic | recessive | heat sensitive
short lived, with Scer\GAL4elav-C155
short lived, with Scer\GAL4repo-M1B
short lived (with Df(3R)BSC496)
short lived (with Df(3R)BSC512)
short lived (with Df(3R)Exel6204)
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
short lived | recessive
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult brain | progressive
adult optic lobe | progressive
embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALDOA
14 of 15
Yes
Yes
Hsap\ALDOC
13 of 15
No
Yes
Hsap\ALDOB
11 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aldoa
14 of 15
Yes
Yes
Mmus\Aldoart2
14 of 15
Yes
Yes
Mmus\Aldoc
12 of 15
No
Yes
Mmus\Aldob
11 of 15
No
Yes
Mmus\Aldoart1
8 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Aldoart2
12 of 13
Yes
Yes
Rnor\Aldoc
12 of 13
Yes
Yes
Rnor\Aldob
11 of 13
No
Yes
Rnor\Aldoa
9 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\aldoc
11 of 12
Yes
Yes
Xtro\aldoa
7 of 12
No
Yes
Xtro\aldob
7 of 12
No
Yes
Danio rerio (Zebrafish) (5)
Drer\aldoaa
13 of 15
Yes
Yes
Drer\aldocb
13 of 15
Yes
Yes
Drer\aldoab
12 of 15
No
Yes
Drer\aldob
11 of 15
No
Yes
Drer\aldoca
11 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\aldo-1
11 of 15
Yes
Yes
Cele\aldo-2
10 of 15
No
Yes
Cele\F07F6.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (8)
Atha\FBA5
9 of 9
Yes
Yes
Atha\FBA7
9 of 9
Yes
Yes
Atha\FBA6
8 of 9
No
Yes
Atha\FBA8
8 of 9
No
Yes
Atha\FBA4
6 of 9
No
Yes
Atha\PDE345
5 of 9
No
Yes
Atha\FBA1
4 of 9
No
Yes
Atha\FBA2
4 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AKG )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ald1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008535
Drosophila simulans
Dsim\GD18141
Drosophila sechellia
Dsec\GM10189
Drosophila erecta
Dere\GG12193
Drosophila yakuba
Dyak\GE10635
Drosophila ananassae
Dana\GF16038
Drosophila pseudoobscura pseudoobscura
Dpse\GA19329
Drosophila willistoni
Dwil\GK13316
Drosophila virilis
Dvir\GJ23350
Drosophila mojavensis
Dmoj\GI10131
Drosophila grimshawi
Dgri\GH18178
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505WS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015203
Musca domestica
House fly
Mdoa\17005054
Glossina morsitans
Tsetse fly
Gmor\GMOY011870
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00343
Mayetiola destructor
Hessian fly
Mdes\Mdes012345
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005766
Anopheles darlingi
American malaria mosquito
Adar\ADAC003632
Anopheles gambiae
Malaria mosquito
Agam\AGAP002564
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009571
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05VP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013021
Danaus plexippus
Monarch butterfly
Dple\DPOGS206961-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206959-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014028
Apis florea
Little honeybee
Aflo\2465358276
Apis mellifera
Western honey bee
Amel\GB40735
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18797
Bombus terrestris
Buff-tailed bumblebee
Bter\15203531
Linepithema humile
Argentine ant
Lhum\LH19280
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0021bd
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013506
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11479
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_14998
Pediculus humanus
Human body louse
Phum\PHUM609020
Rhodnius prolixus
Kissing bug
Rpro\RPRC009816
Cimex lectularius
Bed bug
Clec\CLEC001326
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007027
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12642
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X071J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW011371
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60571.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur109g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g03440
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_188180
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0A9T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldoaa_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldoaa
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000017302
Gallus gallus
Domestic chicken
Ggal\ALDOB
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026077
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    ALDOA; aldolase, fructose-bisphosphate A
    14 of 15
    103850
    ALDOC; aldolase, fructose-bisphosphate C
    13 of 15
    103870
      ALDOB; aldolase, fructose-bisphosphate B
      11 of 15
      612724
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please look at the Interaction Group reports for full details of the physical interactions
      protein-protein
      Interacting group
      Assay
      References
      Ald1
      two hybrid
      (Sullivan et al., 2003)
      Ald1 - ATPsynCF6
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Act79B
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Act88F
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Actn
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Adh
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - AnxB10
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Argk
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Atg14
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Bacc
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG10638
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG13893
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG14207
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG14715
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG16826
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG1910
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG2852
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG31343
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG34172
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG5177
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG5500
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG5506
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - CG8891
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Calr
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Chd64
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Df31
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - EndoGI
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Eno
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Fer2LCH
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Fkbp12
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Fkbp14
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Gapdh2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Glo1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - GlyP
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Gpdh1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Gpo1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - GstO3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - GstS1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Inos
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Lsp2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Mdh2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Mf
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Mhc
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Mlc1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Mlc2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Nacα
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Nlp
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - PCNA
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - PHDP
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      Ald1 - Pgd
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Pgk
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Pglym78
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Picot
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Prm
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Prx2540-2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - RhoGDI
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Scp1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Sh3β
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Sod2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Spindly
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - TER94
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Tm2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - TpnC41C
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Uch
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Yp2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - Yp3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - apolpp
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - awd
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - capt
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - fabp
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - fln
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - ft
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Ald1 - kdn
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - mAcon1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - p23
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - regucalcin
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - scu
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - up
      experimental knowledge based
      (Guruharsha et al., 2011)
      Ald1 - wupA
      experimental knowledge based
      (Guruharsha et al., 2011)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Homotetramer.
      (UniProt, P07764 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Gene Group - Pathway Membership (FlyBase)
      External Data
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-90
      Cytogenetic map
      97A6-97A6
      Sequence location
      3R:26,254,069..26,261,591 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      97A6-97A6
      Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      97B-97B
      (determined by in situ hybridisation)
      (Kim et al., 1992)
      97A-97B
      (determined by in situ hybridisation)
      (Shaw-Lee et al., 1992)
      Experimentally Determined Recombination Data
      Location
      3-90
      (FlyBase, 2016)
      3-87.6
      (Comeron et al., 2012)
      3-
      (Choudhary et al., 1992)
      3-91.5
      Left of (cM)
      Right of (cM)
      (Miller et al., 2012)
      Notes
      Stocks and Reagents
      Stocks (18)
      Genomic Clones (25)
      cDNA Clones (391)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Sullivan et al., 2003)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: Ald1 Ald
      (FlyBase, 2017-)
      Source for database merge of
      Source for merge of: Ald BcDNA:LP07735
      (FlyBase, 1996-)
      Additional comments
      Source for merge of Ald BcDNA:LP07735 was a shared cDNA ( date:030728 ).
      (FlyBase, 1996-)
      Other Comments
      Area matching Drosophila Fructose 1,6 bisphosphare aldolase gene, Acc. No. M98351.
      (Davies, 2001.3.15)
      At least a substantial fraction of three glycolytic enzymes of flight muscle cells are found colocalised at the Z-discs and M-lines, glycolytic enzyme colocalisation is interdependent. Localisation of Gapdh1, Gapdh2 and Ald at the Z-discs and M-lines requires the presence of at least Gpdh at the Z-discs and M-lines.
      (Wojtas et al., 1997)
      The structural gene for aldolase (fructose-biphosphate aldolase).
      Origin and Etymology
      Discoverer
      Etymology
      Renamed from 'Ald' to 'Ald1' in recognition that there's a second Aldolase gene (Ald2/CG5432).
      (FlyBase, 2017-)
      Identification
      External Crossreferences and Linkouts ( 106 )
      Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      InterPro - A database of protein families, domains and functional sites
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      PDB - An information portal to biological macromolecular structures
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
      DPiM - Drosophila Protein interaction map
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMine - An integrated database for Drosophila genomics
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Synonyms and Secondary IDs (16)
      Reported As
      Symbol Synonym
      ALD
      (Liu et al., 2018, Kondo and Perrimon, 2011, Srere and Knull, 1998, Eanes, 1994, Choudhary et al., 1992)
      Ald
      (Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Sridharan et al., 2016, Aradska et al., 2015, Cogni et al., 2015, Dent et al., 2015, Guan et al., 2015, Kwon et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, de la Cova et al., 2014, Gonzalez et al., 2014, Liang et al., 2014, Whitaker et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Nirala et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Eanes, 2011, Friedman et al., 2011, Hartmann et al., 2011, Sun et al., 2011, Blanco et al., 2010, Kong et al., 2010, Wasbrough et al., 2010, Reumer et al., 2009, Christensen et al., 2008.4.15, Harvey et al., 2008, Puri et al., 2008, Ferjoux et al., 2007, Flowers et al., 2007, Dorus et al., 2006, Sullivan et al., 2003, Gim et al., 2001)
      Ald1
      (FlyBase, 2017-)
      Aldolase
      (Smibert et al., 2012)
      BcDNA:LP07735
      CG6058
      (Hosono et al., 2015, Cammarato et al., 2011, Findlay et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.3.31, Reumer et al., 2009, Puri et al., 2008, Huang et al., 2007, Metta et al., 2006, Karlsson et al., 2004, Vierstraete et al., 2004)
      FBA
      (Zou et al., 2000)
      T12
      (Vierstraete et al., 2004)
      T4
      (Vierstraete et al., 2004)
      T6
      (Vierstraete et al., 2004)
      T7
      (Vierstraete et al., 2004)
      ald
      (Hsu et al., 2015, Luck et al., 2014, Dorsett, 1991.6.11)
      dALDOA
      (Yasunaga et al., 2014)
      Name Synonyms
      Aldolase
      (Sridharan et al., 2016, Volkenhoff et al., 2015, Yasunaga et al., 2014, Felix et al., 2012, Miller et al., 2012, Cammarato et al., 2011, Hartmann et al., 2011, Anholt and Williams, 2010, Barnes et al., 2010, Robinson et al., 2010, Reumer et al., 2009, Cho et al., 2005, Manh et al., 2005, Sugimoto et al., 1995)
      Aldolase 1
      (FlyBase, 2017-)
      aldolase
      (Horiguchi et al., 2014, Meyer et al., 2011, Sun et al., 2011, Mack et al., 2006, Sullivan et al., 2003, Kai, 1993.10.19, Kai, 1992.1.31, Malek, 1992.7.28, Malek, 1992.7.28)
      fructose 1,6 biphosphate-aldolase A
      (Zou et al., 2000)
      Secondary FlyBase IDs
      • FBgn0064914
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (145)