FlyBase Gene Report: Dmel\Ald1

ALDEHYDE-LYASES -: Aldehyde-lyases catalyze the cleavage of carbon-carbon bond in alcohols into carbanions and aldehydes. The vast majority are aldolases, involved in carbohydrate metabolism. (Adapted from FBrf0238856).

Protein Function (UniProtKB)

May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).

(UniProt, P07764)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Ald: Aldolase

Structural gene for fructose-biphosphate aldolase (EC 4.1.2.13). Enzyme multimeric based on the formation of heteromultimeric bands on gels from heterozygotes for electrophoretic variants. Amino-acid sequence determined; protein is a 158-kd multimer comprising four 360-amino-acid polypeptides. Monomers show 71% identity with rabbit muscle aldolase (Malek, Suter, Frank, and Brenner-Holzach, 1985, Biochem. Biophys. Res. Comm. 126: 199-205). Mixed multimers of rabbit and Drosophila subunits able to function (Brenner-Holzach and Leuthard, 1972, Eur. J. Biochem. 31: 423-26). Sequence analysis suggests alternating domains of alpha helix and beta sheet; domain boundaries correspond to boundaries between exons as seen in rat-liver aldolase (Sawyer, Fothergill-Gilmore, and Freemont, 1988, Biochem. J. 249: 789-93).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Ald1 or the JBrowse view of Dmel\Ald1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.43

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ald1-RB

FBtr0084994

NM_170262

2636

361

Ald1-RC

FBtr0084995

NM_170263

1279

361

Ald1-RD

FBtr0084999

NM_170264

1483

361

Ald1-RE

FBtr0085000

NM_079791

1747

363

Ald1-RH

FBtr0085001

NM_206577

1618

363

Ald1-RI

FBtr0114544

NM_170266

1736

363

Ald1-RJ

FBtr0306657

NM_170261

1614

363

Ald1-RK

FBtr0310660

NM_170265

1472

361

Ald1-RL

FBtr0310661

NM_001276056

1615

363

Ald1-RM

FBtr0339614

NM_001300612

2102

361

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ald1-PB

FBpp0084367

39.0

361

7.49

NP_733141

AAF56579

Ald1-PC

FBpp0084368

39.0

361

7.49

NP_733142

AAN14381

Ald1-PD

FBpp0084372

39.0

361

7.49

NP_733143

AAN14382

Ald1-PE

FBpp0084373

39.6

363

7.10

NP_524515

AAN14384

Ald1-PH

FBpp0089214

39.6

363

7.87

NP_996300

AAS65220

Ald1-PI

FBpp0113036

39.6

363

7.10

NP_733145

AAN14383

Ald1-PJ

FBpp0297612

39.6

363

7.87

NP_733140

AAN14380

Ald1-PK

FBpp0302780

39.0

361

7.49

NP_733144

AAF56580

Ald1-PL

FBpp0302781

39.6

363

7.87

NP_001262985

AGB96365

Ald1-PM

FBpp0308680

39.0

361

7.49

NP_001287541

AHN57540

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

361 aa isoforms: Ald1-PB, Ald1-PC, Ald1-PD, Ald1-PK, Ald1-PM

363 aa isoforms: Ald1-PE, Ald1-PI

363 aa isoforms: Ald1-PH, Ald1-PJ, Ald1-PL

Additional Polypeptide Data and Comments

Reported size (kDa)

360 (aa)

(Malek et al., 1988)

Comments

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P07764)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

1FBA

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ald1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

fructose-bisphosphate aldolase activity

inferred from direct assay

(Lissemore et al., 1990)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

fructose-bisphosphate aldolase activity

inferred from biological aspect of ancestor with PANTHER:PTN000179343

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

glucose homeostasis

inferred from mutant phenotype

(Ugrankar et al., 2015)

glycolytic process

inferred from direct assay

(Lissemore et al., 1990)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

fructose 1,6-bisphosphate metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000179343

(assigned by GO_Central )

(Gaudet et al., 2011)

glycolytic process

inferred from biological aspect of ancestor with PANTHER:PTN000179343

(assigned by GO_Central )

(Gaudet et al., 2011)

mesoderm development

non-traceable author statement

(Furlong et al., 2001)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

M band

inferred from direct assay

(Sullivan et al., 2003)

Z disc

inferred from direct assay

(Sullivan et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000179343

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Ald transcript levels are unaltered by dietary variations in the level of glucose, fructose, or starch. A small increase in transcript level is seen on 5% sucrose vs. 0.3% sucrose. Ald transcript levels increase slightly in response to starch.

(Lissemore et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

flight muscle

• myofibril | restricted

(Sullivan et al., 2003)

flight muscle

• sarcomere | restricted

(Sullivan et al., 2003)

flight muscle

• M band

(Sullivan et al., 2003)

flight muscle

• Z disc

(Sullivan et al., 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Glycolytic enzymes, including Gpdh protein are localized to M bands and Z discs, as visualized in the isolated myofibrils of flight muscles, where immunoreactivity appears as alternating bright and less-intense bands.

(Sullivan et al., 2003)

Ald enzyme levelsare not significantly influenced by dietary sucrose, glucose, or fructose.Activity was slightly elevated in response to starch. Ald levelsdecrease slightly on 9% ethanol compared to 1% ethanol.

(Lissemore et al., 1990)

Marker for

Subcellular Localization

CV Term

Evidence

References

cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

M band

inferred from direct assay

(Sullivan et al., 2003)

Z disc

inferred from direct assay

(Sullivan et al., 2003)

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}Ald1^CPTI002230

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval CNS perineurial glial cell

(Volkenhoff et al., 2015)

adult stage

horizontal fiber system neuron

(Knowles-Barley, 2011.8.24)

calyx of adult mushroom body

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ald1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ald1

View exonic expression by tissue for Dmel\Ald1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000064

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000064

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6058-RB;CG6058-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6058

Flygut - An atlas of the Drosophila adult midgut

FBgn0000064

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ald1

Transgenic constructs containing regulatory region of Ald1

Deletions and Duplications ( 4 )

Disrupted in

Df(3R)BSC496

(Miller et al., 2012)

Df(3R)BSC512

(Christensen et al., 2008.4.15)

Df(3R)Exel6204

(Miller et al., 2012)

Df(3R)Tl-P

(Miller et al., 2012)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ald1^GD17138

lethal, with Scer\GAL4^da.PU

Ald1^GD17138

lethal, with Scer\GAL4^Tub.PU

Ald1^GD17138

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ald1^GD17138

lethal - all die during embryonic stage, with Scer\GAL4^Mef2.PR

Ald1^GD11803

partially lethal, with Scer\GAL4^repo.PU

Ald1^GD17138

viable

Ald1^EY13155

viable, with Scer\GAL4^nSyb.PS

Ald1^GD17138

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

Ald1^EY13155

Other Phenotypes

Allele

electrophoretic variant | fast

Ald1⁴

electrophoretic variant | slow

Ald1²

flightless, with Scer\GAL4^Mef2.PR

Ald1^GD17138

neuroanatomy defective | adult stage, with Scer\GAL4^repo-M1B

Ald1^GD17138

neuroanatomy defective | progressive (with Df(3R)BSC496)

Ald1^m4

neuroanatomy defective | progressive (with Df(3R)BSC512)

Ald1^m4

neuroanatomy defective | progressive (with Df(3R)Exel6204)

Ald1^m4

neuroanatomy defective | progressive | recessive

Ald1^m4

paralytic | heat sensitive (with Df(3R)BSC496)

Ald1^m4

paralytic | heat sensitive (with Df(3R)BSC512)

Ald1^m4

paralytic | heat sensitive (with Df(3R)Exel6204)

Ald1^m4

paralytic | heat sensitive (with Df(3R)Tl-P)

Ald1^m4

paralytic | recessive | heat sensitive

Ald1^m4

short lived, with Scer\GAL4^elav-C155

Ald1^GD17138

short lived, with Scer\GAL4^repo-M1B

Ald1^GD17138

short lived (with Df(3R)BSC496)

Ald1^m4

short lived (with Df(3R)BSC512)

Ald1^m4

short lived (with Df(3R)Exel6204)

Ald1^m4

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Ald1^GD11803

short lived | recessive

Ald1^m4

visible, with Scer\GAL4^pnr-MD237

Ald1^GD11803

Phenotype manifest in

Allele

adult brain | progressive

Ald1^m4

adult optic lobe | progressive

Ald1^m4

embryonic/larval somatic muscle, with Scer\GAL4^Mef2.PR

trichogen cell, with Scer\GAL4^pnr-MD237

Ald1^GD11803

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ALDOA

14 of 15

Yes

Hsap\ALDOC

13 of 15

Yes

Hsap\ALDOB

11 of 15

Yes

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Aldoa

14 of 15

Yes

Mmus\Aldoart2

14 of 15

Yes

Mmus\Aldoc

12 of 15

Yes

Mmus\Aldob

11 of 15

Yes

Mmus\Aldoart1

8 of 15

Yes

Rattus norvegicus (Norway rat) (4)

Rnor\Aldoart2

12 of 13

Yes

Rnor\Aldoc

12 of 13

Yes

Rnor\Aldob

11 of 13

Yes

Rnor\Aldoa

9 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\aldoc

11 of 12

Yes

Xtro\aldoa

7 of 12

Yes

Xtro\aldob

7 of 12

Yes

Danio rerio (Zebrafish) (5)

Drer\aldoaa

13 of 15

Yes

Drer\aldocb

13 of 15

Yes

Drer\aldoab

12 of 15

Yes

Drer\aldob

11 of 15

Yes

Drer\aldoca

11 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\aldo-1

11 of 15

Yes

Cele\aldo-2

10 of 15

Yes

Cele\F07F6.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (8)

Atha\FBA5

9 of 9

Yes

Atha\FBA7

9 of 9

Yes

Atha\FBA6

8 of 9

Yes

Atha\FBA8

8 of 9

Yes

Atha\FBA4

6 of 9

Yes

Atha\PDE345

5 of 9

Yes

Atha\FBA1

4 of 9

Yes

Atha\FBA2

4 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AKG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Ald1

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19329

Drosophila willistoni

Dwil\GK13316

Drosophila virilis

Dvir\GJ23350

Drosophila mojavensis

Dmoj\GI10131

Drosophila grimshawi

Dgri\GH18178

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505WS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015203

Musca domestica

House fly

Mdoa\17005054

Glossina morsitans

Tsetse fly

Gmor\GMOY011870

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00343

Mayetiola destructor

Hessian fly

Mdes\Mdes012345

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005766

Anopheles darlingi

American malaria mosquito

Adar\ADAC003632

Anopheles gambiae

Malaria mosquito

Agam\AGAP002564

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009571

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05VP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013021

Danaus plexippus

Monarch butterfly

Dple\DPOGS206961-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206959-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014028

Apis florea

Little honeybee

Aflo\2465358276

Apis mellifera

Western honey bee

Amel\GB40735

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18797

Bombus terrestris

Buff-tailed bumblebee

Bter\15203531

Linepithema humile

Argentine ant

Lhum\LH19280

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021bd

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013506

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11479

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_14998

Pediculus humanus

Human body louse

Phum\PHUM609020

Rhodnius prolixus

Kissing bug

Rpro\RPRC009816

Cimex lectularius

Bed bug

Clec\CLEC001326

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007027

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12642

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X071J )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW011371

Stegodyphus mimosarum

African social velvet spider

Smim\KFM60571.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur109g00010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g03440

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_188180

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0A9T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Aldoaa_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Aldoaa

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000017302

Gallus gallus

Domestic chicken

Ggal\ALDOB

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026077

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

7 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

chromosome 16p11.2 deletion syndrome

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ALDOB; aldolase, fructose-bisphosphate B

model of hereditary fructose intolerance syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ALDOA; aldolase, fructose-bisphosphate A

14 of 15

103850

GLYCOGEN STORAGE DISEASE XII; GSD12

ALDOC; aldolase, fructose-bisphosphate C

13 of 15

103870

ALDOB; aldolase, fructose-bisphosphate B

11 of 15

612724

FRUCTOSE INTOLERANCE, HEREDITARY

hereditary fructose intolerance syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ald1

two hybrid

(Sullivan et al., 2003)

Ald1 - ATPsynCF6

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Act79B

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Act88F

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Actn

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Adh

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Argk

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Atg14

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Bacc

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG10638

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG13893

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG14207

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG14715

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG16826

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG1910

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG2852

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG31343

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG34172

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG5177

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG5500

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG5506

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - CG8891

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Calr

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Df31

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - EndoGI

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Eno

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Fer2LCH

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Fkbp12

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Fkbp14

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Gapdh2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Glo1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - GlyP

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Gpdh1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Gpo1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - GstO3

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - GstS1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Inos

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Lsp2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Mdh2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Mf

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Mhc

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Mlc1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Mlc2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Nlp

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - PCNA

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - PHDP

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Ald1 - Pgd

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Pgk

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Pglym78

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Picot

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Prm

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Prx2540-2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - RhoGDI

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Scp1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Sod2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Spindly

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - TER94

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Tm2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - TpnC41C

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Uch

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Yp2

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - Yp3

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - apolpp

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - awd

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - capt

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - fabp

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - fln

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - ft

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Ald1 - kdn

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - mAcon1

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - p23

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - scu

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - up

experimental knowledge based

(Guruharsha et al., 2011)

Ald1 - wupA

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P07764 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68080

DroID - A comprehensive database of gene and protein interactions.

FBgn0000064

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43183

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Gene Group - Pathway Membership (FlyBase)

External Data

Linkouts

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-90

Cytogenetic map

97A6-97A6

Sequence location

3R:26,254,069..26,261,591 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97A6-97A6

Limits computationally determined from genome sequence between P{PZ}l(3)rQ197^rQ197 and P{lacW}scrib^j7B3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

97B-97B

(determined by in situ hybridisation)

(Kim et al., 1992)

97A-97B

(determined by in situ hybridisation)

(Shaw-Lee et al., 1992)

Experimentally Determined Recombination Data

Location

3-90

(FlyBase, 2016)

3-87.6

(Comeron et al., 2012)

(Choudhary et al., 1992)

3-91.5

Left of (cM)

Right of (cM)

(Miller et al., 2012)

Notes

Stocks and Reagents

Stocks (18)

Bloomington

26301

y¹ v¹; P{TRiP.JF02071}attP2

34186

y¹ w^*; Mi{MIC}Ald1^MI01394

56602

y¹ w^*; Mi{MIC}Ald1^MI11399

20862

y¹ w^67c23; P{EPgy2}Ald1^EY13155

d00219

d04529

d07992

115279

w¹¹¹⁸; PBac{768.FSVS-0}Ald1^CPTI002230

VDRC

v101339

P{KK107680}VIE-260B

v27541

w¹¹¹⁸ P{GD11803}v27541

v47667

w¹¹¹⁸; P{GD17138}v47667

v47668

w¹¹¹⁸; P{GD17138}v47668/CyO

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (391)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000064

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000064

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43183

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Sullivan et al., 2003)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ald1 Ald

(FlyBase, 2017-)

Source for database merge of

Source for merge of: Ald BcDNA:LP07735

(FlyBase, 1996-)

Additional comments

Source for merge of Ald BcDNA:LP07735 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Other Comments

Area matching Drosophila Fructose 1,6 bisphosphare aldolase gene, Acc. No. M98351.

(Davies, 2001.3.15)

At least a substantial fraction of three glycolytic enzymes of flight muscle cells are found colocalised at the Z-discs and M-lines, glycolytic enzyme colocalisation is interdependent. Localisation of Gapdh1, Gapdh2 and Ald at the Z-discs and M-lines requires the presence of at least Gpdh at the Z-discs and M-lines.

(Wojtas et al., 1997)

The structural gene for aldolase (fructose-biphosphate aldolase).

Origin and Etymology

Discoverer

Etymology

Renamed from 'Ald' to 'Ald1' in recognition that there's a second Aldolase gene (Ald2/CG5432).

(FlyBase, 2017-)

Identification

External Crossreferences and Linkouts ( 123 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43183

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P07764

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000064

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000064

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000064

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6058

Flygut - An atlas of the Drosophila adult midgut

FBgn0000064

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43183

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014998

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6058

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

modMine - A data warehouse for the modENCODE project

FBgn0000064

PDB - An information portal to biological macromolecular structures

1FBA

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Linkouts

BioGRID - A database of protein and genetic interactions.

68080

DPiM - Drosophila Protein interaction map

FBgn0000064

DroID - A comprehensive database of gene and protein interactions.

FBgn0000064

DRSC - Results frm RNAi screens

FBgn0000064

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000064

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6058-RB;CG6058-RA

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

FlyMine - An integrated database for Drosophila genomics

FBgn0000064

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43183

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

ALD

(Liu et al., 2018, Kondo and Perrimon, 2011, Srere and Knull, 1998, Eanes, 1994, Choudhary et al., 1992)

ALDOA

(Chi et al., 2019)

Ald

(Ariss et al., 2018, Park et al., 2018, Ugrankar et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Sridharan et al., 2016, Aradska et al., 2015, Cogni et al., 2015, Dent et al., 2015, Guan et al., 2015, Kwon et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, de la Cova et al., 2014, Gonzalez et al., 2014, Liang et al., 2014, Whitaker et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Nirala et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Eanes, 2011, Friedman et al., 2011, Hartmann et al., 2011, Sun et al., 2011, Blanco et al., 2010, Kong et al., 2010, Wasbrough et al., 2010, Reumer et al., 2009, Christensen et al., 2008.4.15, Harvey et al., 2008, Puri et al., 2008, Ferjoux et al., 2007, Flowers et al., 2007, Dorus et al., 2006, Sullivan et al., 2003, Gim et al., 2001)

Ald1

(FlyBase, 2017-)

Aldolase

(Smibert et al., 2012)

BcDNA:LP07735

CG6058

(Chi et al., 2019, Hosono et al., 2015, Cammarato et al., 2011, Findlay et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.3.31, Reumer et al., 2009, Puri et al., 2008, Huang et al., 2007, Metta et al., 2006, Karlsson et al., 2004, Vierstraete et al., 2004)

FBA

(Zou et al., 2000)

T12

(Vierstraete et al., 2004)

ald

(Hsu et al., 2015, Luck et al., 2014, Dorsett, 1991.6.11)

dALDOA

(Yasunaga et al., 2014)

Name Synonyms

Aldolase

(Sridharan et al., 2016, Volkenhoff et al., 2015, Yasunaga et al., 2014, Felix et al., 2012, Miller et al., 2012, Cammarato et al., 2011, Hartmann et al., 2011, Anholt and Williams, 2010, Barnes et al., 2010, Robinson et al., 2010, Reumer et al., 2009, Cho et al., 2005, Manh et al., 2005, Sugimoto et al., 1995)

Aldolase 1

(FlyBase, 2017-)

aldolase

(Horiguchi et al., 2014, Meyer et al., 2011, Sun et al., 2011, Mack et al., 2006, Sullivan et al., 2003, Kai, 1993.10.19, Kai, 1992.1.31, Malek, 1992.7.28, Malek, 1992.7.28)

fructose 1,6 biphosphate-aldolase A

(Zou et al., 2000)

Secondary FlyBase IDs

FBgn0064914

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (152)

Report Sections

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