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Gene Dmel\Ald

General Information
Symbol	Dmel\Ald	Species	D. melanogaster
Name	Aldolase	Annotation symbol	CG6058
Feature type	protein_coding_gene	FlyBase ID	FBgn0000064
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-91.5
Cytogenetic map	97A6-97A6	Sequence location	3R:22,079,791..22,087,313 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Aldolase is referred to in FlyBase by the symbol Dmel\Ald (CG6058, FBgn0000064). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: fructose-bisphosphate aldolase activity. There is experimental evidence that it is involved in the biological process: mitotic G2 DNA damage checkpoint; glycolysis. 14 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Aldolase-type TIM barrel; Fructose-bisphosphate aldolase, class-I. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Gene sequence location is 3R:22079791..22087313.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ald: Aldolase Structural gene for fructose-biphosphate aldolase (EC 4.1.2.13). Enzyme multimeric based on the formation of heteromultimeric bands on gels from heterozygotes for electrophoretic variants. Amino-acid sequence determined; protein is a 158-kd multimer comprising four 360-amino-acid polypeptides. Monomers show 71% identity with rabbit muscle aldolase (Malek, Suter, Frank, and Brenner-Holzach, 1985, Biochem. Biophys. Res. Comm. 126: 199-205). Mixed multimers of rabbit and Drosophila subunits able to function (Brenner-Holzach and Leuthard, 1972, Eur. J. Biochem. 31: 423-26). Sequence analysis suggests alternating domains of alpha helix and beta sheet; domain boundaries correspond to boundaries between exons as seen in rat-liver aldolase (Sawyer, Fothergill-Gilmore, and Freemont, 1988, Biochem. J. 249: 789-93).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Ald[m4] Ald[CH322-98F06] Ald[Scer\UAS.cMa] Transgenic Constructs P{UAS-Ald.M} PBac{CH322-98F06}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97A6-97A6   Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97B-97B   (determined by in situ hybridisation)   (Kim et al., 1992) 97A-97B   (determined by in situ hybridisation)   (Shaw-Lee et al., 1992)
Experimentally Determined Recombination Data
Location	3-91.5   3- (Choudhary et al., 1992)
Left of (cM)
Right of (cM)	H (Miller et al., 2012)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ald for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.49 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ald-RB FBtr0084994  NM_170262   2636   361 Ald-RC FBtr0084995  NM_170263   1279   361 Ald-RD FBtr0084999  NM_170264   1483   361 Ald-RE FBtr0085000  NM_079791   1747   363 Ald-RH FBtr0085001  NM_206577   1618   363 Ald-RI FBtr0114544  NM_170266   1736   363 Ald-RJ FBtr0306657  NM_170261   1614   363 Ald-RK FBtr0310660  NM_170265   1472   361 Ald-RL FBtr0310661  NM_001276056   1615   363 Ald-RM FBtr0339614     2102   361
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ald-PB   FBpp0084367   39.0   361   7.49     NP_733141   AAF56579 Ald-PC   FBpp0084368   39.0   361   7.49     NP_733142   AAN14381 Ald-PD   FBpp0084372   39.0   361   7.49     NP_733143   AAN14382 Ald-PE   FBpp0084373   39.6   363   7.10     NP_524515   AAN14384 Ald-PH   FBpp0089214   39.6   363   7.87     NP_996300   AAS65220 Ald-PI   FBpp0113036   39.6   363   7.10     NP_733145   AAN14383 Ald-PJ   FBpp0297612   39.6   363   7.87     NP_733140   AAN14380 Ald-PK   FBpp0302780   39.0   361   7.49     NP_733144   AAF56580 Ald-PL   FBpp0302781   39.6   363   7.87     NP_001262985   AGB96365 Ald-PM   FBpp0308680   39.0   361   7.49
Additional Polypeptide Data & Comments
Reported size (kDa)	360 (aa) (Malek et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aldolase-type TIM barrel (IPR013785) Fructose-bisphosphate aldolase, class-I (IPR000741) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1FBA
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246872   AA439208   AA439216   AA567066   AA567630   AA567658   AA697817   AA698240   AA803144   AA816320   AA950477   AA978477   AE014297 AAF56579   AE014297 AAF56580   AE014297 AAN14380   AE014297 AAN14381   AE014297 AAN14382   AE014297 AAN14383   AE014297 AAN14384   AE014297 AAS65220   AE014297 AGB96365   AI062458   AI062526   AI063396   AI064492   AI106681   AI106837   AI107294   AI107455   AI108109   AI108120   AI108181   AI108193   AI109523   AI109706   AI113440   AI113463   AI113771   AI135191   AI135538   AI238220   AI257390   AI258007   AI258635   AI259643   AI259670   AI260623   AI294376   AI295447   AI296322   AI296349   AI297031   AI386957   AI387047   AI387264   AI388457   AI388471   AI403492   AI403980   AI406122   AI455948   AI456338   AI513831   AI517072   AI517616   AI517816   AI518363   AI518435   AI519915   AI531509   AI543641   AI946854   AW943398   AW944013   AX093932   AY058667 AAL13896   AY128452 AAM75045   BE977199   BE978313   BF494944   BF497042   BF501430   BF501703   BF503262   BF505819   BG632724   BG633067   BG640261   BG640632   BG641193   BI141798   BI142142   BI163259   BI164154   BI164418   BI164576   BI164695   BI165223   BI165322   BI165361   BI165740   BI165828   BI167576   BI167939   BI168801   BI170133   BI170519   BI170568   BI170744   BI172266   BI172595   BI173801   BI173949   BI212373   BI212934   BI212971   BI213911   BI214062   BI214952   BI215094   BI215168   BI215684   BI216028   BI227448   BI227673   BI228536   BI228592   BI228609   BI231096   BI231782   BI234559   BI235068   BI235725   BI236793   BI238065   BI238640   BI239457   BI240936   BI241388   BI241464   BI242341   BI356218   BI356500   BI357309   BI361770   BI362441   BI363083   BI363314   BI363315   BI363546   BI363774   BI365339   BI369556   BI369682   BI370471   BI370519   BI370540   BI370618   BI370754   BI371093   BI371313   BI371678   BI372556   BI372569   BI373569   BI375054   BI376078   BI481552   BI482329   BI482745   BI482987   BI483987   BI484096   BI484429   BI485304   BI485343   BI486279   BI486511   BI486876   BI563584   BI564434   BI564582   BI566076   BI566139   BI566254   BI566924   BI567171   BI567174   BI567508   BI569465   BI569965   BI570159   BI570213   BI570509   BI574518   BI575369   BI575928   BI576115   BI576190   BI576803   BI576826   BI577470   BI579519   BI581803   BI582820   BI583075   BI583698   BI583824   BI584018   BI584463   BI585883   BI587067   BI587825   BI588160   BI588545   BI588696   BI589073   BI589394   BI589818   BI590578   BI592155   BI592175   BI593373   BI604365   BI604801   BI608119   BI609700   BI610771   BI611079   BI613634   BI617206   BI617815   BI619222   BI620162   BI620644   BI621119   BI621316   BI621484   BI621623   BI622564   BI622734   BI624012   BI624647   BI625472   BI626540   BI628409   BI628545   BI628660   BI628663   BI628902   BI629757   BI630546   BI630707   BI632208   BI633036   BI633108   BI634510   BI634707   BI635248   BI636792   BI638113   BI639393   BI639846   BI640573   BI640814   BI641123   BP553338   BP553339   BQ102650   BQ102859   BQ103464   BQ103540   BQ103701   BT003560 AAO39564   BT031233   BT099760   BT126163   BT126261   BT126276   BT126303   BX007774   BX010134   BX015460   BX034051   BX036702   BX043259   BX048903   BX057542   BX064168   BX065075   CA806758   CK132138   CK659098   CL943560   CO153622   CO156109   CO182183   CO187749   CO190026   CO190398   CO190420   CO190465   CO196565   CO263115   CO265651   CO266488   CO271979   CO276285   CO277070   CO277250   CO277272   CO277858   CO277973   CO282086   CO283652   CO284301   CO289771   CO290382   CO291077   CO291485   CO293242   CO295553   CO296972   CO297360   CO302662   CO303188   CO305303   CO307852   CO311160   CO311698   CO312609   CO312806   CO313276   CO314007   CO315654   CO320170   CO322312   CO325006   CO327421   CO329313   CO331256   CO332884   CO335703   CO335728   CO336605   CO340247   CO343055   CR938686   CZ471463   CZ477727   CZ477728   D10446 BAA01236   D10446 BAA01237   D10446 BAA01238   D10762 BAA01592   DN154217   DN154261   DQ443365   EC056836   EC061045   EC062094   EC062988   EC063088   EC063688   EC072878   EC076155   EC076576   EC080554   EC083185   EC086357   EC086942   EC087258   EC088791   EC089597   EC197544   EC201060   EC203481   EC204798   EC205322   EC206913   EC212344   EC212549   EC214430   EC215030   EC217281   EC219169   EC219421   EC221459   EC223352   EC225034   EC225313   EC233446   EC237121   EC245397   EC245541   EC247072   EC248385   EC248436   EC249490   EC249501   EC249650   EC253674   EC258049   EC261817   EC264113   EC264612   EC266647   EC266790   EC267821   EL870877   EL870951   EL872091   EL872092   EL872202   EL872203   EL872221   EL875752   EL875753   EL875903   EL876027   EL876028   EL883690   EL884127   EL884257   ES689964   ES690001   ES690002   ES690012   ES692083   ES692085   ES692086   ES692089   ES692092   ES692094   ES692095   ES692096   ES692097   ES692098   ES692100   ES692101   ES692758   EV575353   EV575364   EV575753   EV577903   EV578081   EV578428   EV578432   EV579293   EV580925   EV581264   EV581576   EV582784   EV583044   EV583342   EV583576   EV583773   EV585117   EV585377   EV586086   EV591407   EV593878   EV594296   EV594322   EV594808   EV595221   EV595230   EV595259   EV595777   EV596041   EV596650   EV596754   EV597224   EV598001   EV598635   EV599007   EV600044   EV600484   EV600701   GH947445   GH949685   GH950250   GH952569   GH961300   GH966333   GH967117   GH969636   GH972780   GH975089   GH975492   GH983042   GH984276   M98351 AAA99426   M98351 AAA99427   M98351 AAA99428   M98352   X60064 CAA42666   X60064 CAA42667   X60064 CAA42668
UniProtKB/Swiss-Prot	P07764
UniProtKB/TrEMBL	A4V3G1 Q86NZ4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	Ald transcript levels are unaltered by dietary variations in the level of glucose, fructose, or starch. A small increase in transcript level is seen on 5% sucrose vs. 0.3% sucrose. Ald transcript levels increase slightly in response to starch. (Lissemore et al., 1990)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   flight muscle   • myofibril | restricted (Sullivan et al., 2003) flight muscle   • sarcomere | restricted (Sullivan et al., 2003) flight muscle   • M band (Sullivan et al., 2003) flight muscle   • Z disc (Sullivan et al., 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Glycolytic enzymes, including Gpdh protein are localized to M bands and Z discs, as visualized in the isolated myofibrils of flight muscles, where immunoreactivity appears as alternating bright and less-intense bands. (Sullivan et al., 2003) Ald enzyme levelsare not significantly influenced by dietary sucrose, glucose, or fructose.Activity was slightly elevated in response to starch. Ald levelsdecrease slightly on 9% ethanol compared to 1% ethanol. (Lissemore et al., 1990)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
M band inferred from direct assay (Sullivan et al., 2003) Z disc inferred from direct assay (Sullivan et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    148 central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female    429 head, virgin 4-day female    284 head, virgin 20-day female    310 head, mated 1-day female    320 head, mated 4-day female    208 head, mated 20-day female    303 head, mated 1-day male    457 head, mated 4-day male    357 head, mated 20-day male    311 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    174 digestive system, 4-day adult    152 digestive system, 20-day adult    188 fat body, larvae L3 wandering    149 fat body, white prepupae    65 fat body, pupae P8    119 carcass, larvae L3 wandering    141 carcass, 1-day adult    1123 carcass, 4-day adult    774 carcass, 20-day adult    472 ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male    184 accessory gland, mated 4-day male    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (148) central nervous system, larvae L3  (70) central nervous system, pupae P8  (91) head, virgin 1-day female  (429) head, virgin 4-day female  (284) head, virgin 20-day female  (310) head, mated 1-day female  (320) head, mated 4-day female  (208) head, mated 20-day female  (303) head, mated 1-day male  (457) head, mated 4-day male  (357) head, mated 20-day male  (311) salivary gland, larvae L3 wandering  (36) salivary gland, white prepupae    20 digestive system, larvae L3 wandering  (38) digestive system, 1-day adult  (174) digestive system, 4-day adult  (152) digestive system, 20-day adult  (188) fat body, larvae L3 wandering  (149) fat body, white prepupae  (65) fat body, pupae P8  (119) carcass, larvae L3 wandering  (141) carcass, 1-day adult  (1123) carcass, 4-day adult  (774) carcass, 20-day adult  (472) ovary, virgin 4-day female  (70) ovary, mated 4-day female  (62) testis, mated 4-day male  (184) accessory gland, mated 4-day male  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (148) central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female  (429) head, virgin 4-day female  (284) head, virgin 20-day female  (310) head, mated 1-day female  (320) head, mated 4-day female  (208) head, mated 20-day female  (303) head, mated 1-day male  (457) head, mated 4-day male  (357) head, mated 20-day male  (311) salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult  (174) digestive system, 4-day adult  (152) digestive system, 20-day adult  (188) fat body, larvae L3 wandering  (149) fat body, white prepupae    65 fat body, pupae P8  (119) carcass, larvae L3 wandering  (141) carcass, 1-day adult  (1123) carcass, 4-day adult  (774) carcass, 20-day adult  (472) ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male  (184) accessory gland, mated 4-day male  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    148 central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female    429 head, virgin 4-day female    284 head, virgin 20-day female    310 head, mated 1-day female    320 head, mated 4-day female    208 head, mated 20-day female    303 head, mated 1-day male    457 head, mated 4-day male    357 head, mated 20-day male    311 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    174 digestive system, 4-day adult    152 digestive system, 20-day adult    188 fat body, larvae L3 wandering    149 fat body, white prepupae    65 fat body, pupae P8    119 carcass, larvae L3 wandering    141 carcass, 1-day adult    1123 carcass, 4-day adult    774 carcass, 20-day adult    472 ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male    184 accessory gland, mated 4-day male    105 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    148 central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female    429 head, virgin 4-day female    284 head, virgin 20-day female    310 head, mated 1-day female    320 head, mated 4-day female    208 head, mated 20-day female    303 head, mated 1-day male    457 head, mated 4-day male    357 head, mated 20-day male    311 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    174 digestive system, 4-day adult    152 digestive system, 20-day adult    188 fat body, larvae L3 wandering    149 fat body, white prepupae    65 fat body, pupae P8    119 carcass, larvae L3 wandering    141 carcass, 1-day adult    1123 carcass, 4-day adult    774 carcass, 20-day adult    472 ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male    184 accessory gland, mated 4-day male    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (148) central nervous system, larvae L3  (70) central nervous system, pupae P8  (91) head, virgin 1-day female  (429) head, virgin 4-day female  (284) head, virgin 20-day female  (310) head, mated 1-day female  (320) head, mated 4-day female  (208) head, mated 20-day female  (303) head, mated 1-day male  (457) head, mated 4-day male  (357) head, mated 20-day male  (311) salivary gland, larvae L3 wandering  (36) salivary gland, white prepupae    20 digestive system, larvae L3 wandering  (38) digestive system, 1-day adult  (174) digestive system, 4-day adult  (152) digestive system, 20-day adult  (188) fat body, larvae L3 wandering  (149) fat body, white prepupae  (65) fat body, pupae P8  (119) carcass, larvae L3 wandering  (141) carcass, 1-day adult  (1123) carcass, 4-day adult  (774) carcass, 20-day adult  (472) ovary, virgin 4-day female  (70) ovary, mated 4-day female  (62) testis, mated 4-day male  (184) accessory gland, mated 4-day male  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (148) central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female  (429) head, virgin 4-day female  (284) head, virgin 20-day female  (310) head, mated 1-day female  (320) head, mated 4-day female  (208) head, mated 20-day female  (303) head, mated 1-day male  (457) head, mated 4-day male  (357) head, mated 20-day male  (311) salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult  (174) digestive system, 4-day adult  (152) digestive system, 20-day adult  (188) fat body, larvae L3 wandering  (149) fat body, white prepupae    65 fat body, pupae P8  119 carcass, larvae L3 wandering  141 carcass, 1-day adult  (1123) carcass, 4-day adult  (774) carcass, 20-day adult  (472) ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male  (184) accessory gland, mated 4-day male  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    148 central nervous system, larvae L3    70 central nervous system, pupae P8    91 head, virgin 1-day female    429 head, virgin 4-day female    284 head, virgin 20-day female    310 head, mated 1-day female    320 head, mated 4-day female    208 head, mated 20-day female    303 head, mated 1-day male    457 head, mated 4-day male    357 head, mated 20-day male    311 salivary gland, larvae L3 wandering    36 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    38 digestive system, 1-day adult    174 digestive system, 4-day adult    152 digestive system, 20-day adult    188 fat body, larvae L3 wandering    149 fat body, white prepupae    65 fat body, pupae P8    119 carcass, larvae L3 wandering    141 carcass, 1-day adult    1123 carcass, 4-day adult    774 carcass, 20-day adult    472 ovary, virgin 4-day female    70 ovary, mated 4-day female    62 testis, mated 4-day male    184 accessory gland, mated 4-day male    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr    107 embryo 12-14hr    129 embryo 14-16hr    358 embryo 16-18hr    397 embryo 18-20hr    457 embryo 20-22hr    452 embryo 22-24hr    481 larva L1    752 larva L2    632 larva L3 12hr old    709 larva L3 puffstage 1-2    433 larva L3 puffstage 3-6    275 larva L3 puffstage 7-9    122 white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP    239 pupae 3d postWPP    498 pupae 4d postWPP    666 adult male 01day    807 adult male 05day    753 adult male 30day    373 adult female 01day    594 adult female 05day    209 adult female 30day    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (68) embryo 04-06hr  (59) embryo 06-08hr  (36) embryo 08-10hr  (59) embryo 10-12hr  (107) embryo 12-14hr  (129) embryo 14-16hr  (358) embryo 16-18hr  (397) embryo 18-20hr  (457) embryo 20-22hr  (452) embryo 22-24hr  (481) larva L1  (752) larva L2  (632) larva L3 12hr old  (709) larva L3 puffstage 1-2  (433) larva L3 puffstage 3-6  (275) larva L3 puffstage 7-9  (122) white prepupae new  (78) white prepupae 12hr  (48) white prepupae 24hr  (61) pupae 2d postWPP  (239) pupae 3d postWPP  (498) pupae 4d postWPP  (666) adult male 01day  (807) adult male 05day  (753) adult male 30day  (373) adult female 01day  (594) adult female 05day  (209) adult female 30day  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr  107 embryo 12-14hr  (129) embryo 14-16hr  (358) embryo 16-18hr  (397) embryo 18-20hr  (457) embryo 20-22hr  (452) embryo 22-24hr  (481) larva L1  (752) larva L2  (632) larva L3 12hr old  (709) larva L3 puffstage 1-2  (433) larva L3 puffstage 3-6  (275) larva L3 puffstage 7-9  (122) white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP  (239) pupae 3d postWPP  (498) pupae 4d postWPP  (666) adult male 01day  (807) adult male 05day  (753) adult male 30day  (373) adult female 01day  (594) adult female 05day  (209) adult female 30day  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr    107 embryo 12-14hr    129 embryo 14-16hr    358 embryo 16-18hr    397 embryo 18-20hr    457 embryo 20-22hr    452 embryo 22-24hr    481 larva L1    752 larva L2    632 larva L3 12hr old    709 larva L3 puffstage 1-2    433 larva L3 puffstage 3-6    275 larva L3 puffstage 7-9    122 white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP    239 pupae 3d postWPP    498 pupae 4d postWPP    666 adult male 01day    807 adult male 05day    753 adult male 30day    373 adult female 01day    594 adult female 05day    209 adult female 30day    117 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr    107 embryo 12-14hr    129 embryo 14-16hr    358 embryo 16-18hr    397 embryo 18-20hr    457 embryo 20-22hr    452 embryo 22-24hr    481 larva L1    752 larva L2    632 larva L3 12hr old    709 larva L3 puffstage 1-2    433 larva L3 puffstage 3-6    275 larva L3 puffstage 7-9    122 white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP    239 pupae 3d postWPP    498 pupae 4d postWPP    666 adult male 01day    807 adult male 05day    753 adult male 30day    373 adult female 01day    594 adult female 05day    209 adult female 30day    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (68) embryo 04-06hr  (59) embryo 06-08hr  (36) embryo 08-10hr  (59) embryo 10-12hr  (107) embryo 12-14hr  (129) embryo 14-16hr  (358) embryo 16-18hr  (397) embryo 18-20hr  (457) embryo 20-22hr  (452) embryo 22-24hr  (481) larva L1  (752) larva L2  (632) larva L3 12hr old  (709) larva L3 puffstage 1-2  (433) larva L3 puffstage 3-6  (275) larva L3 puffstage 7-9  (122) white prepupae new  (78) white prepupae 12hr  (48) white prepupae 24hr  (61) pupae 2d postWPP  (239) pupae 3d postWPP  (498) pupae 4d postWPP  (666) adult male 01day  (807) adult male 05day  (753) adult male 30day  (373) adult female 01day  (594) adult female 05day  (209) adult female 30day  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr  107 embryo 12-14hr  129 embryo 14-16hr  (358) embryo 16-18hr  (397) embryo 18-20hr  (457) embryo 20-22hr  (452) embryo 22-24hr  (481) larva L1  (752) larva L2  (632) larva L3 12hr old  (709) larva L3 puffstage 1-2  (433) larva L3 puffstage 3-6  (275) larva L3 puffstage 7-9  122 white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP  (239) pupae 3d postWPP  (498) pupae 4d postWPP  (666) adult male 01day  (807) adult male 05day  (753) adult male 30day  (373) adult female 01day  (594) adult female 05day  (209) adult female 30day  117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    68 embryo 04-06hr    59 embryo 06-08hr    36 embryo 08-10hr    59 embryo 10-12hr    107 embryo 12-14hr    129 embryo 14-16hr    358 embryo 16-18hr    397 embryo 18-20hr    457 embryo 20-22hr    452 embryo 22-24hr    481 larva L1    752 larva L2    632 larva L3 12hr old    709 larva L3 puffstage 1-2    433 larva L3 puffstage 3-6    275 larva L3 puffstage 7-9    122 white prepupae new    78 white prepupae 12hr    48 white prepupae 24hr    61 pupae 2d postWPP    239 pupae 3d postWPP    498 pupae 4d postWPP    666 adult male 01day    807 adult male 05day    753 adult male 30day    373 adult female 01day    594 adult female 05day    209 adult female 30day    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    123 embryonic 1182-4H    81 embryonic GM2    136 embryonic Kc167    210 embryonic S1    222 embryonic S3    64 leg disc CME L1    116 wing disc CME-W2    145 wing disc ML-DmD8    148 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    112 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    229 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1    145 CNS ML-DmBG1-c1    118 CNS ML-DmBG2-c2    84 tumorous blood cells mbn2    237 ovary fGS/OSS    147 ovary OSC    131 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (123) embryonic 1182-4H  (81) embryonic GM2  (136) embryonic Kc167  (210) embryonic S1  (222) embryonic S3  (64) leg disc CME L1  (116) wing disc CME-W2  (145) wing disc ML-DmD8  (148) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3  (132) wing disc ML-DmD21  (112) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (229) eye-antennal disc ML-DmD11  (77) antennal disc ML-DmD20-c5  (91) mixed discs ML-DmD4-c1  (145) CNS ML-DmBG1-c1  (118) CNS ML-DmBG2-c2  (84) tumorous blood cells mbn2  (237) ovary fGS/OSS  (147) ovary OSC  (131) ovary OSS  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4  (123) embryonic 1182-4H    81 embryonic GM2  (136) embryonic Kc167  (210) embryonic S1  (222) embryonic S3    64 leg disc CME L1  (116) wing disc CME-W2  (145) wing disc ML-DmD8  (148) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3  (132) wing disc ML-DmD21  (112) wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  (229) eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1  (145) CNS ML-DmBG1-c1  (118) CNS ML-DmBG2-c2    84 tumorous blood cells mbn2  (237) ovary fGS/OSS  (147) ovary OSC  (131) ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    123 embryonic 1182-4H    81 embryonic GM2    136 embryonic Kc167    210 embryonic S1    222 embryonic S3    64 leg disc CME L1    116 wing disc CME-W2    145 wing disc ML-DmD8    148 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    112 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    229 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1    145 CNS ML-DmBG1-c1    118 CNS ML-DmBG2-c2    84 tumorous blood cells mbn2    237 ovary fGS/OSS    147 ovary OSC    131 ovary OSS    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    123 embryonic 1182-4H    81 embryonic GM2    136 embryonic Kc167    210 embryonic S1    222 embryonic S3    64 leg disc CME L1    116 wing disc CME-W2    145 wing disc ML-DmD8    148 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    112 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    229 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1    145 CNS ML-DmBG1-c1    118 CNS ML-DmBG2-c2    84 tumorous blood cells mbn2    237 ovary fGS/OSS    147 ovary OSC    131 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (61) Schneider line 2 Sg4  (123) embryonic 1182-4H  (81) embryonic GM2  (136) embryonic Kc167  (210) embryonic S1  (222) embryonic S3  (64) leg disc CME L1  (116) wing disc CME-W2  (145) wing disc ML-DmD8  (148) wing disc ML-DmD9  (140) wing disc ML-DmD16-c3  (132) wing disc ML-DmD21  (112) wing disc ML-DmD32  (92) haltere disc ML-DmD17-c3  (229) eye-antennal disc ML-DmD11  (77) antennal disc ML-DmD20-c5  (91) mixed discs ML-DmD4-c1  (145) CNS ML-DmBG1-c1  (118) CNS ML-DmBG2-c2  (84) tumorous blood cells mbn2  (237) ovary fGS/OSS  (147) ovary OSC  (131) ovary OSS  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4  123 embryonic 1182-4H    81 embryonic GM2  136 embryonic Kc167  (210) embryonic S1  (222) embryonic S3    64 leg disc CME L1  116 wing disc CME-W2  (145) wing disc ML-DmD8  (148) wing disc ML-DmD9  140 wing disc ML-DmD16-c3  132 wing disc ML-DmD21  112 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3  (229) eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1  (145) CNS ML-DmBG1-c1  118 CNS ML-DmBG2-c2    84 tumorous blood cells mbn2  (237) ovary fGS/OSS  (147) ovary OSC  131 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    61 Schneider line 2 Sg4    123 embryonic 1182-4H    81 embryonic GM2    136 embryonic Kc167    210 embryonic S1    222 embryonic S3    64 leg disc CME L1    116 wing disc CME-W2    145 wing disc ML-DmD8    148 wing disc ML-DmD9    140 wing disc ML-DmD16-c3    132 wing disc ML-DmD21    112 wing disc ML-DmD32    92 haltere disc ML-DmD17-c3    229 eye-antennal disc ML-DmD11    77 antennal disc ML-DmD20-c5    91 mixed discs ML-DmD4-c1    145 CNS ML-DmBG1-c1    118 CNS ML-DmBG2-c2    84 tumorous blood cells mbn2    237 ovary fGS/OSS    147 ovary OSC    131 ovary OSS    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    128 cold shock, 4-day adult    90 heat shock, 4-day adult    473 Cadmium 50 mM 6 hrs, larvae L3    627 Cadmium 50 mM 12 hrs, larvae L3    412 Cadmium 50 mM 48 hrs, 4-day adult    496 Cadmium 100 mM 48 hrs, 4-day adult    210 Copper 0.5 mM 12 hrs, larvae L3    536 Copper 15 mM 48 hrs, 4-day adult    711 Zinc 5 mM 12 hrs, larvae L3    369 Zinc 4.5 mM 48 hrs, 4-day adult    473 Ethanol 2.5% 3 hrs, larvae L3    313 Ethanol 5% 3 hrs, larvae L3    478 Ethanol 10% 3 hrs, larvae L3    732 Caffeine 1.5 mg/ml 4 hrs, larvae L3    564 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    242 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    360 Paraquat 10 mM 48 hrs, 4-day adult    501 Rotenone 2 μg 12 hrs, larvae L3    586 Rotenone 8 μg 12 hrs, larvae L3    882 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (128) cold shock, 4-day adult  (90) heat shock, 4-day adult  (473) Cadmium 50 mM 6 hrs, larvae L3  (627) Cadmium 50 mM 12 hrs, larvae L3  (412) Cadmium 50 mM 48 hrs, 4-day adult  (496) Cadmium 100 mM 48 hrs, 4-day adult  (210) Copper 0.5 mM 12 hrs, larvae L3  (536) Copper 15 mM 48 hrs, 4-day adult  (711) Zinc 5 mM 12 hrs, larvae L3  (369) Zinc 4.5 mM 48 hrs, 4-day adult  (473) Ethanol 2.5% 3 hrs, larvae L3  (313) Ethanol 5% 3 hrs, larvae L3  (478) Ethanol 10% 3 hrs, larvae L3  (732) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (564) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (242) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (360) Paraquat 10 mM 48 hrs, 4-day adult  (501) Rotenone 2 μg 12 hrs, larvae L3  (586) Rotenone 8 μg 12 hrs, larvae L3  (882) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (128) cold shock, 4-day adult    90 heat shock, 4-day adult  (473) Cadmium 50 mM 6 hrs, larvae L3  (627) Cadmium 50 mM 12 hrs, larvae L3  (412) Cadmium 50 mM 48 hrs, 4-day adult  (496) Cadmium 100 mM 48 hrs, 4-day adult  (210) Copper 0.5 mM 12 hrs, larvae L3  (536) Copper 15 mM 48 hrs, 4-day adult  (711) Zinc 5 mM 12 hrs, larvae L3  (369) Zinc 4.5 mM 48 hrs, 4-day adult  (473) Ethanol 2.5% 3 hrs, larvae L3  (313) Ethanol 5% 3 hrs, larvae L3  (478) Ethanol 10% 3 hrs, larvae L3  (732) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (564) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (242) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (360) Paraquat 10 mM 48 hrs, 4-day adult  (501) Rotenone 2 μg 12 hrs, larvae L3  (586) Rotenone 8 μg 12 hrs, larvae L3  (882) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    128 cold shock, 4-day adult    90 heat shock, 4-day adult    473 Cadmium 50 mM 6 hrs, larvae L3    627 Cadmium 50 mM 12 hrs, larvae L3    412 Cadmium 50 mM 48 hrs, 4-day adult    496 Cadmium 100 mM 48 hrs, 4-day adult    210 Copper 0.5 mM 12 hrs, larvae L3    536 Copper 15 mM 48 hrs, 4-day adult    711 Zinc 5 mM 12 hrs, larvae L3    369 Zinc 4.5 mM 48 hrs, 4-day adult    473 Ethanol 2.5% 3 hrs, larvae L3    313 Ethanol 5% 3 hrs, larvae L3    478 Ethanol 10% 3 hrs, larvae L3    732 Caffeine 1.5 mg/ml 4 hrs, larvae L3    564 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    242 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    360 Paraquat 10 mM 48 hrs, 4-day adult    501 Rotenone 2 μg 12 hrs, larvae L3    586 Rotenone 8 μg 12 hrs, larvae L3    882 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    128 cold shock, 4-day adult    90 heat shock, 4-day adult    473 Cadmium 50 mM 6 hrs, larvae L3    627 Cadmium 50 mM 12 hrs, larvae L3    412 Cadmium 50 mM 48 hrs, 4-day adult    496 Cadmium 100 mM 48 hrs, 4-day adult    210 Copper 0.5 mM 12 hrs, larvae L3    536 Copper 15 mM 48 hrs, 4-day adult    711 Zinc 5 mM 12 hrs, larvae L3    369 Zinc 4.5 mM 48 hrs, 4-day adult    473 Ethanol 2.5% 3 hrs, larvae L3    313 Ethanol 5% 3 hrs, larvae L3    478 Ethanol 10% 3 hrs, larvae L3    732 Caffeine 1.5 mg/ml 4 hrs, larvae L3    564 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    242 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    360 Paraquat 10 mM 48 hrs, 4-day adult    501 Rotenone 2 μg 12 hrs, larvae L3    586 Rotenone 8 μg 12 hrs, larvae L3    882 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (128) cold shock, 4-day adult  (90) heat shock, 4-day adult  (473) Cadmium 50 mM 6 hrs, larvae L3  (627) Cadmium 50 mM 12 hrs, larvae L3  (412) Cadmium 50 mM 48 hrs, 4-day adult  (496) Cadmium 100 mM 48 hrs, 4-day adult  (210) Copper 0.5 mM 12 hrs, larvae L3  (536) Copper 15 mM 48 hrs, 4-day adult  (711) Zinc 5 mM 12 hrs, larvae L3  (369) Zinc 4.5 mM 48 hrs, 4-day adult  (473) Ethanol 2.5% 3 hrs, larvae L3  (313) Ethanol 5% 3 hrs, larvae L3  (478) Ethanol 10% 3 hrs, larvae L3  (732) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (564) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (242) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (360) Paraquat 10 mM 48 hrs, 4-day adult  (501) Rotenone 2 μg 12 hrs, larvae L3  (586) Rotenone 8 μg 12 hrs, larvae L3  (882) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  128 cold shock, 4-day adult    90 heat shock, 4-day adult  (473) Cadmium 50 mM 6 hrs, larvae L3  (627) Cadmium 50 mM 12 hrs, larvae L3  (412) Cadmium 50 mM 48 hrs, 4-day adult  (496) Cadmium 100 mM 48 hrs, 4-day adult  (210) Copper 0.5 mM 12 hrs, larvae L3  (536) Copper 15 mM 48 hrs, 4-day adult  (711) Zinc 5 mM 12 hrs, larvae L3  (369) Zinc 4.5 mM 48 hrs, 4-day adult  (473) Ethanol 2.5% 3 hrs, larvae L3  (313) Ethanol 5% 3 hrs, larvae L3  (478) Ethanol 10% 3 hrs, larvae L3  (732) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (564) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (242) Caffeine 25 mg/ml 48 hrs, 4-day adult  (148) Paraquat 5 mM 48 hrs, 4-day adult  (360) Paraquat 10 mM 48 hrs, 4-day adult  (501) Rotenone 2 μg 12 hrs, larvae L3  (586) Rotenone 8 μg 12 hrs, larvae L3  (882) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    128 cold shock, 4-day adult    90 heat shock, 4-day adult    473 Cadmium 50 mM 6 hrs, larvae L3    627 Cadmium 50 mM 12 hrs, larvae L3    412 Cadmium 50 mM 48 hrs, 4-day adult    496 Cadmium 100 mM 48 hrs, 4-day adult    210 Copper 0.5 mM 12 hrs, larvae L3    536 Copper 15 mM 48 hrs, 4-day adult    711 Zinc 5 mM 12 hrs, larvae L3    369 Zinc 4.5 mM 48 hrs, 4-day adult    473 Ethanol 2.5% 3 hrs, larvae L3    313 Ethanol 5% 3 hrs, larvae L3    478 Ethanol 10% 3 hrs, larvae L3    732 Caffeine 1.5 mg/ml 4 hrs, larvae L3    564 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    242 Caffeine 25 mg/ml 48 hrs, 4-day adult    148 Paraquat 5 mM 48 hrs, 4-day adult    360 Paraquat 10 mM 48 hrs, 4-day adult    501 Rotenone 2 μg 12 hrs, larvae L3    586 Rotenone 8 μg 12 hrs, larvae L3    882 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000064 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6058-RB;CG6058-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4tub.PU AldGD17138 viable AldEY13155 viable, with Scer\GAL4pnr-MD237 AldGD11803 AldGD17138 Sterility Allele fertile AldEY13155 Other Phenotypes Allele electrophoretic variant | fast Ald4 electrophoretic variant | slow Ald2 neuroanatomy defective | adult stage, with Scer\GAL4repo-M1B AldGD17138 neuroanatomy defective | progressive (with Df(3R)BSC496) Aldm4 neuroanatomy defective | progressive (with Df(3R)BSC512) Aldm4 neuroanatomy defective | progressive (with Df(3R)Exel6204) Aldm4 neuroanatomy defective | progressive | recessive Aldm4 paralytic | heat sensitive (with Df(3R)BSC496) Aldm4 paralytic | heat sensitive (with Df(3R)BSC512) Aldm4 paralytic | heat sensitive (with Df(3R)Exel6204) Aldm4 paralytic | heat sensitive (with Df(3R)Tl-P) Aldm4 paralytic | recessive | heat sensitive Aldm4 short lived, with Scer\GAL4elav-C155 AldGD17138 short lived, with Scer\GAL4repo-M1B AldGD17138 short lived (with Df(3R)BSC496) Aldm4 short lived (with Df(3R)BSC512) Aldm4 short lived (with Df(3R)Exel6204) Aldm4 short lived | recessive Aldm4 visible, with Scer\GAL4pnr-MD237 AldGD11803 Phenotype manifest in Allele adult brain | progressive Aldm4 optic lobe | progressive Aldm4 trichogen cell, with Scer\GAL4pnr-MD237 AldGD11803
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Ald Class Mutagen Stocks Known lesion Ald2 natural population 2 -- Ald4 natural population 2 -- Aldd00219 P-element activity 1 -- Aldd04529 1 -- Aldd07992 1 -- AldEY13155 P-element activity 1 -- AldMI01394 1 -- AldCPTI002230 piggyBac transposase 0 Yes Aldd11445 P-element activity 0 -- Aldm4 hypomorphic allele - molecular evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ald Class Mutagen Stocks Known lesion AldGD11803 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AldGD17138 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AldJF02071 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AldKK107680 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AldCH322-98F06 in vitro construct - genomic fragment 0 Yes AldNIG.6058R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes AldScer\UAS.cMa 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC496 (Miller et al., 2012) Df(3R)BSC512 (Christensen et al., 2008.4.15) Df(3R)Exel6204 (Miller et al., 2012) Df(3R)Tl-P (Miller et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11803} NA P{GD17138} NA P{KK107680} NA P{NIG.6058R} NA P{TRiP.JF02071} NA P{UAS-Ald.M} NA characterization construct PBac{CH322-98F06} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}AldEY13155 NA P{XP}Aldd00219 NA P{XP}Aldd04529 NA P{XP}Aldd07992 NA P{XP}Aldd11445 NA miscellaneous insertions Mi{MIC}AldMI01394 NA PBac{768.FSVS-0}AldCPTI002230 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
fructose-bisphosphate aldolase activity inferred from direct assay (Lissemore et al., 1990)
Biological Process
CV term Evidence References
glycolysis inferred from direct assay (Lissemore et al., 1990) mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011)
Cellular Component
CV term Evidence References
M band inferred from direct assay (Sullivan et al., 2003) Z disc inferred from direct assay (Sullivan et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
fructose-bisphosphate aldolase activity inferred from sequence or structural similarity with mouse Aldoa (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Biological Process
CV term Evidence References
glycolysis non-traceable author statement (Swiss-Prot Project Members, 1988.8.1) mesoderm development non-traceable author statement (Furlong et al., 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ald - ATPsyn-Cf6 experimental knowledge based (Guruharsha et al., 2011) Ald - Acon experimental knowledge based (Guruharsha et al., 2011) Ald - Act79B experimental knowledge based (Guruharsha et al., 2011) Ald - Act88F experimental knowledge based (Guruharsha et al., 2011) Ald - Actn experimental knowledge based (Guruharsha et al., 2011) Ald - Adh experimental knowledge based (Guruharsha et al., 2011) Ald - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Ald - Argk experimental knowledge based (Guruharsha et al., 2011) Ald - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Atg14 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ald - Bacc experimental knowledge based (Guruharsha et al., 2011) Ald - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG10638 experimental knowledge based (Guruharsha et al., 2011) Ald - CG10657 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG11407 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG11811 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG13893 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ald - CG14207 experimental knowledge based (Guruharsha et al., 2011) Ald - CG14715 experimental knowledge based (Guruharsha et al., 2011) Ald - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG16817 experimental knowledge based (Guruharsha et al., 2011) Ald - CG16826 experimental knowledge based (Guruharsha et al., 2011) Ald - CG1707 experimental knowledge based (Guruharsha et al., 2011) Ald - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG1910 experimental knowledge based (Guruharsha et al., 2011) Ald - CG2004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG2852 experimental knowledge based (Guruharsha et al., 2011) Ald - CG31343 experimental knowledge based (Guruharsha et al., 2011) Ald - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG34172 experimental knowledge based (Guruharsha et al., 2011) Ald - CG4586 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG4645 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG5177 experimental knowledge based (Guruharsha et al., 2011) Ald - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG5432 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG5500 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ald - CG5506 experimental knowledge based (Guruharsha et al., 2011) Ald - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG8147 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG8654 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - CG8891 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ald - Chd64 experimental knowledge based (Guruharsha et al., 2011) Ald - Crc experimental knowledge based (Guruharsha et al., 2011) Ald - Df31 experimental knowledge based (Guruharsha et al., 2011) Ald - EndoGI experimental knowledge based (Guruharsha et al., 2011) Ald - Eno experimental knowledge based (Guruharsha et al., 2011) Ald - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Ald - Fer2LCH experimental knowledge based (Guruharsha et al., 2011) Ald - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Ald - Gapdh2 experimental knowledge based (Guruharsha et al., 2011) Ald - GlyP experimental knowledge based (Guruharsha et al., 2011) Ald - Gpdh experimental knowledge based (Guruharsha et al., 2011) Ald - Gpo-1 experimental knowledge based (Guruharsha et al., 2011) Ald - GstO3 experimental knowledge based (Guruharsha et al., 2011) Ald - GstS1 experimental knowledge based (Guruharsha et al., 2011) Ald - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Iap2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Inos experimental knowledge based (Guruharsha et al., 2011) Ald - Lsp2 experimental knowledge based (Guruharsha et al., 2011) Ald - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Ald - Mf experimental knowledge based (Guruharsha et al., 2011) Ald - Mhc experimental knowledge based (Guruharsha et al., 2011) Ald - Mlc1 experimental knowledge based (Guruharsha et al., 2011) Ald - Mlc2 experimental knowledge based (Guruharsha et al., 2011) Ald - Nacα experimental knowledge based (Guruharsha et al., 2011) Ald - Nlp experimental knowledge based (Guruharsha et al., 2011) Ald - Pgd experimental knowledge based (Guruharsha et al., 2011) Ald - Pgk experimental knowledge based (Guruharsha et al., 2011) Ald - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Ald - Picot anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ald - Pli anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Prm experimental knowledge based (Guruharsha et al., 2011) Ald - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Ald - Rfabg experimental knowledge based (Guruharsha et al., 2011) Ald - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Ald - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Scp1 experimental knowledge based (Guruharsha et al., 2011) Ald - Sh3β experimental knowledge based (Guruharsha et al., 2011) Ald - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Sod2 experimental knowledge based (Guruharsha et al., 2011) Ald - Spindly experimental knowledge based (Guruharsha et al., 2011) Ald - TER94 experimental knowledge based (Guruharsha et al., 2011) Ald - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Tm2 experimental knowledge based (Guruharsha et al., 2011) Ald - TpnC41C experimental knowledge based (Guruharsha et al., 2011) Ald - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - Uch experimental knowledge based (Guruharsha et al., 2011) Ald - Yp2 experimental knowledge based (Guruharsha et al., 2011) Ald - Yp3 experimental knowledge based (Guruharsha et al., 2011) Ald - ZnT63C anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - awd experimental knowledge based (Guruharsha et al., 2011) Ald - capt experimental knowledge based (Guruharsha et al., 2011) Ald - clu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - fabp experimental knowledge based (Guruharsha et al., 2011) Ald - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - fln experimental knowledge based (Guruharsha et al., 2011) Ald - igl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - kdn experimental knowledge based (Guruharsha et al., 2011) Ald - loqs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - mus209 experimental knowledge based (Guruharsha et al., 2011) Ald - pps anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ald - regucalcin anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ald - scu experimental knowledge based (Guruharsha et al., 2011) Ald - up experimental knowledge based (Guruharsha et al., 2011) Ald - wupA experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ald allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68080 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000064 DroID - A comprehensive database of gene and protein interactions. • FBgn0000064 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43183
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JWW0H Dipteran inclusive ortholog search EOG6BG94P Insect inclusive ortholog search EOG6PK14M Arthropod inclusive ortholog search EOG69W0X2 Metazoa inclusive ortholog search EOG69WF89
Orthologs in Drosophila Species (EOG6JWW0H)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ald     Drosophila simulans   Dsim\GD18141 Y   Drosophila sechellia   Dsec\GM10189 Y   Drosophila erecta   Dere\GG12193 Y   Drosophila yakuba   Dyak\GE10635 Y   Drosophila ananassae   Dana\GF16038 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19329 Y   Drosophila willistoni   Dwil\GK13316 Y   Drosophila virilis   Dvir\GJ23350 Y   Drosophila mojavensis   Dmoj\GI10131 Y   Drosophila grimshawi   Dgri\GH18178 Y
Orthologs in non-Drosophila Dipterans (EOG6BG94P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005766   Anopheles gambiae Malaria mosquito  Agam\AGAP002564   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009571
Orthologs in non-Dipteran Insects (EOG6PK14M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40735 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013506 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25236 Y Atta cephalotes Leafcutter ant  Acep\ACEP20352 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO15027 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20338 Y Linepithema humile Argentine ant  Lhum\LH19280 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB12196 Y Solenopsis invicta Red fire ant  Sinv\SINV12263 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007027 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013021 Y Pediculus humanus Human body louse  Phum\PHUM609020 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_14998 Y
Orthologs in non-Insect Arthropods (EOG69W0X2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_188180 Y Ixodes scapularis Deer tick  Isca\ISCW011371 Y
Orthologs in non-Arthropod Metazoa (EOG69WF89)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\aldo-2 Y Caenorhabditis elegans Nematode  Cele\T05D4.1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016486gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027563gn Y Danio rerio Zebrafish  Drer\aldocb Y Danio rerio Zebrafish  Drer\aldoab Y Danio rerio Zebrafish  Drer\aldob Y Danio rerio Zebrafish  Drer\aldoca Y Danio rerio Zebrafish  Drer\aldoaa Y Xenopus tropicalis Western clawed frog  Xtro\aldoa Y Xenopus tropicalis Western clawed frog  Xtro\aldob Y Xenopus tropicalis Western clawed frog  Xtro\aldoc Y Gallus gallus Domestic chicken  Ggal\ALDOB Y Mus musculus House mouse  Mmus\Aldoart1 Y Mus musculus House mouse  Mmus\Aldoc Y Mus musculus House mouse  Mmus\Aldoa Y Mus musculus House mouse  Mmus\Aldob Y Mus musculus House mouse  Mmus\Aldoart2 Y Rattus norvegicus Norway rat  Rnor\Aldoa Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000028542 Y Rattus norvegicus Norway rat  Rnor\Aldoal1 Y Rattus norvegicus Norway rat  Rnor\Aldoc Y Rattus norvegicus Norway rat  Rnor\Aldob Y Homo sapiens Human  Hsap\ALDOB Y Homo sapiens Human  Hsap\ALDOC Y Homo sapiens Human  Hsap\ENSG00000149925 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\ALDOB     Hsap\ALDOC     Hsap\ENSG00000149925
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18141 Drosophila sechellia Dsec\GM10189 Drosophila erecta Dere\GG12193 Drosophila yakuba Dyak\GE10635 Drosophila ananassae Dana\GF16038 Drosophila pseudoobscura pseudoobscura Dpse\GA19329 Drosophila willistoni Dwil\GK13316 Drosophila virilis Dvir\GJ23350 Drosophila mojavensis Dmoj\GI10131 Drosophila grimshawi Dgri\GH18178
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	26301 y1 v1; P{TRiP.JF02071}attP2 34186 y1 w*; Mi{MIC}AldMI01394 20862 y1 w67c23; P{EPgy2}AldEY13155 4018 IdhF SodF Pgm6tr Ald2/TM3, IdhS SodS Pgm4tr Sb1 Ald4 Ser1
Harvard	- P{XP}Aldd00219 - P{XP}Aldd04529 - P{XP}Aldd07992
VDRC	v101339 P{KK107680}VIE-260B v27541 w1118 P{GD11803}v27541 v27542 w1118; P{GD11803}v27542 v47667 w1118; P{GD17138}v47667 v47668 w1118; P{GD17138}v47668/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR08N16 BACR19L21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 445 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT05679 LD37852 LP03138 LP07735
Other clones	DPiM_LD37852 FI14712 FI14722 IP05604 IP21843 MIP06295
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03732 AT08207 AT11093 AT16759 AT17176 AT19212 GH01669 GH01751 GH03184 GH04937 GH05148 GH06074 GH06864 GH06951 GH06964 GH08962 GH14231 GH17745 GH19503 GH23544 GH26325 GH26936 GH27704 GH28645 GM01062 GM10307 HL01592 HL04004 LD01192 LD13705 LD13716 LD30702 LD36280 LP03110 LP04555 LP05738 LP10182 LP10215 RE02613 RE03757 RE04276 RE04419 RE05063 RE05686 RE11492 RE12009 RE12314 RE15128 RE16910 RE17105 RE17465 RE18209 RE18258 RE21118 RE21310 RE21506 RE22822 RE24495 RE24782 RE26101 RE26205 RE30275 RE30871 RE34437 RE35943 RE37902 RE38443 RE38543 RE39643 RE42667 RE43747 RE46129 RE46992 RE48088 RE48090 RE55771 RE55947 RE57166 RE57203 RE57915 RE58612 RE59551 RE64008 RE64124 RE65483 RE65805 RE67531 RE70355 RE71153 RH01535 RH02494 RH02854 RH03314 RH04219 RH09781 RH09809 RH16539 RH24432 RH30101 RH30749 RH33442 RH52832 RH56385 RH57165 RH57168 RH59815 RH59991 RH69692 SD02579 SD10509 SD11238 SD11759 SD12473 SD15712 SD16148 SD16541 SD18616 SD20320 SD21961 SD22542 SD23489 SD23817 SD24326 SD25866 SD26994 SD27091
Other clones	4924 16303 16666 33324 34080 44172 44954 46910 60322 61312 62614 67246 70286 70927 72556 72603 73215 77344 81815 97522 100882 102601 104924 105669 106248 106265 120676 145629 146832 149718 149919 153699 157064 164873 190089 214243.12 214439.11 280434 522616 523137 527150 542641 542677 558044 bs31h04 bs60h06 bs76h10 CK01.6B.F1 CK01.38C.D4 CK01.57D.G5 CK01.92B.E11 CK01.98B.E6 CK01.117C.A4 CK01.146B.F6 Dmel_dig_000204_0659_0503 Dmel_dig_001047_0676_0306 Dmel_dig_003075_0599_0524 Dmel_dig_004224_0631_0487 Dmel_dig_004403_0687_0548 Dmel_dig_005476_0644_1012 Dmel_dig_006150_0724_0565 Dmel_dig_007748_0623_1539 Dmel_dig_008792_0631_0560 Dmel_dig_009600_0680_1664 Dmel_dig_011829_0623_2829 Dmel_dig_012729_0600_2916 Dmel_dig_012796_0607_2290 Dmel_dig_013637_0711_0673 Dmel_dig_013668_0599_3578 Dmel_dig_013864_0594_2006 Dmel_dig_016138_0698_0677 Dmel_dig_017567_0629_1484 Dmel_dig_020173_0607_0675 Dmel_neb_000935_0575_3725 Dmel_neb_001793_0852_2239 Dmel_neb_002459_0697_0642 Dmel_neb_008302_0601_1757 Dmel_neb_009451_0938_2212 Dmel_neb_009627_0694_3411 Dmel_neb_010127_0948_2000 Dmel_neb_010384_0843_0655 Dmel_neb_010847_0858_2618 Dmel_neb_011369_0868_1240 Dmel_neb_011994_0597_2745 Dmel_neb_012108_0603_1897 Dmel_neb_012852_0939_3364 Dmel_neb_013220_0604_3255 Dmel_neb_013432_0602_1432 Dmel_neb_013922_0850_2422 Dmel_neb_014205_0328_0692 Dmel_neb_015179_0946_0806 Dmel_neb_016014_0701_2649 EC22222 EK005834 EK032646 EK046027 EK048030 EK048125 EK048256 EK072020 EK073832 EK076051 EK079724 EK087522 EK105353 EK120255 EK122847 EK123531 EK123708 EK127048 EK127940 EK143309 EK146552 EK159510 EK164010 EK165715 EK184642 EK187856 EK195360 EK201715 EK202231 EK206602 EK210662 EK215558 EK216808 EK223632 EK225926 EK229513 EK230008 EK232051 EK234701 EK240455 EK248125 EK255843 EK262120 EK282608 EK292547 EK298919 EK304962 EN02450 EN07349 EN11025 EN11064 EN12862 EP06942 EP10258 EP16024 ESG014d.E21_F08 FGM223H07 GH03877 GH06757 GH06851 GH08745 GH09612 GH09760 GH10225 GH12849 GH13337 GH17350 GH17471 GH19381 GH19404 GH22944 GH28879 HL01553 HL03209 IP02964 IP03064 IP04076 IP04163 IP04176 IP05704 IP05804 IP05904 IP13342 IP15487 IP15587 LD05851 LD30284 LD35686 LD37941 LD39761 LP01872 LP06562 LP09078 LP11184 LP13423 LP16590 RC0-DA0003-130700-021-a03 RC0-DA0003-130700-021-b01 RC0-DA0003-130700-021-b08 RC0-DA0003-130700-021-c04 RC0-DA0003-130700-021-d08 RC0-DA0003-130700-021-f02 RC0-DA0003-130700-021-f05 RC0-DA0003-130700-021-g02 RC0-DA0003-130700-021-g05 RC0-DA0003-130700-021-h04 RE04085 RE05185 RE05241 RE05790 RE07987 RE08454 RE09683 RE12076 RE14580 RE17984 RE19553 RE19764 RE22269 RE24322 RE26176 RE31644 RE32912 RE35145 RE42315 RE47809 RE48388 RE48716 RE50616 RE57103 RE57320 RE57489 RE58180 RE59564 RE60892 RE62774 RE65009 RE66984 RE67130 RE68612 RE68654 RE69690 RE69948 RE73565 RH02175 RH02430 RH11389 RH12285 RH14520 RH17188 RH19612 RH21236 RH21520 RH22364 RH22525 RH22770 RH23676 RH25576 RH27335 RH28713 RH29258 RH29904 RH30951 RH32317 RH32618 RH32703 RH33467 RH33828 RH34246 RH35182 RH35285 RH35455 RH36727 RH37029 RH37032 RH37920 RH38683 RH38926 RH42836 RH47466 RH48263 RH50210 RH51235 RH51834 RH52417 RH52639 RH52991 RH54457 RH54647 RH56790 RH56979 RH57667 RH58667 RH61709 RH61884 RH64241 RH65905 RH67515 RH70279 RP004142521 RP004172309 RP004180422 RP004200340 RP004209548 RP004215085 RP004341497 RP004350270 RP004392142 RP004438970 RP004471708 RP004480678 RP004536143 UUGC0025 UUGC0251 UUGC0870 UUGC0947 UUGC1112
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000064 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43183
Antibody Information
	polyclonal (Sullivan et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ald BcDNA:LP07735 (FlyBase, 1996-)
Additional comments	Source for merge of Ald BcDNA:LP07735 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila Fructose 1,6 bisphosphare aldolase gene, Acc. No. M98351. (Davies, 2001.3.15) At least a substantial fraction of three glycolytic enzymes of flight muscle cells are found colocalised at the Z-discs and M-lines, glycolytic enzyme colocalisation is interdependent. Localisation of Gapdh1, Gapdh2 and Ald at the Z-discs and M-lines requires the presence of at least Gpdh at the Z-discs and M-lines. (Wojtas et al., 1997) The structural gene for aldolase (fructose-biphosphate aldolase).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079791 NM_170261 NM_170262 NM_170263 NM_170264 NM_170265 NM_170266 NM_206577 NM_001276056 RefSeq (Proteins) • NP_524515 NP_733140 NP_733141 NP_733142 NP_733143 NP_733144 NP_733145 NP_996300 NP_001262985 DDBJ / EMBL / GenBank • AAA99426 AAA99427 AAA99428 AAF56579 AAF56580 AAL13896 AAM75045 AAN14380 AAN14381 AAN14382 AAN14383 AAN14384 AAO39564 AAS65220 AGB96365 AI257390 AI259643 AI259670 AI294376 AI518363 AI946854 AW943398 AW944013 AX093932 AY058667 AY128452 BAA01236 BAA01237 BAA01238 BAA01592 BT003560 CAA42666 CAA42667 CAA42668 CL943560 CZ471463 CZ477727 CZ477728 D10446 D10762 M98351 M98352 X60064 Entrez Gene - A searchable database of RefSeq genes. • 43183 UniProtKB/Swiss-Prot • P07764 UniProtKB/TrEMBL • A4V3G1 Q86NZ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aldolase-type TIM barrel (IPR013785) Fructose-bisphosphate aldolase, class-I (IPR000741) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1FBA
Linkouts
	BioGRID - A database of protein and genetic interactions • 68080 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000064 DroID - A comprehensive database of gene and protein interactions. • FBgn0000064 DRSC - Results from RNAi screens. • FBgn0000064 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000064 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6058-RB;CG6058-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000064 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43183 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43183 modMine - Data generated by the modENCODE project. • FBgn0000064
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	ald (Dorsett, 1991.6.11) ALD (Srere and Knull, 1998, Eanes, 1994, Choudhary et al., 1992, Kondo and Perrimon, 2011) Ald (Flowers et al., 2007, Blanco et al., 2010, Christensen et al., 2008.4.15, Dorus et al., 2006, Hartmann et al., 2011, Harvey et al., 2008, Sullivan et al., 2003, Gim et al., 2001, Wasbrough et al., 2010, Sun et al., 2011, Reumer et al., 2009, Ferjoux et al., 2007, Puri et al., 2008, Japanese National Institute of Genetics, 2012.5.21) Aldolase (Smibert et al., 2012) BcDNA:LP07735   CG6058 (Karlsson et al., 2004, Vierstraete et al., 2004, Metta et al., 2006, Huang et al., 2007, Perkins et al., 2009.3.31, Findlay et al., 2009, Keleman et al., 2009.8.5, Reumer et al., 2009, Cammarato et al., 2011, Puri et al., 2008) FBA (Zou et al., 2000) T4 (Vierstraete et al., 2004) T6 (Vierstraete et al., 2004) T7 (Vierstraete et al., 2004) T12 (Vierstraete et al., 2004)
Name Synonym	aldolase (Malek, 1992.7.28, Malek, 1992.7.28, Kai, 1993.10.19, Kai, 1992.1.31, Mack et al., 2006, Sullivan et al., 2003, Sun et al., 2011, Meyer et al., 2011) Aldolase (Sugimoto et al., 1995, Cho et al., 2005, Manh et al., 2005, Hartmann et al., 2011, Miller et al., 2012, Anholt and Williams, 2010, Robinson et al., 2010, Barnes et al., 2010, Reumer et al., 2009, Cammarato et al., 2011, Felix et al., 2012) fructose 1,6 biphosphate-aldolase A (Zou et al., 2000)
Secondary FlyBase IDs
	FBgn0064914
References ( 94 )
Generate a list of	All references relating to this gene ( 94 )
List References by type	Research paper  ( 53 ) Supplementary material  ( 11 ) Review  ( 2 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 6 ) Stock list  ( 1 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 6 )
	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Miller et al., 2012, J. Neurogenet. 26(3-4): 317--327 A mutation in Drosophila Aldolase Causes Temperature-Sensitive Paralysis, Shortened Lifespan, and Neurodegeneration. [FBrf0220234] Hartmann et al., 2011, RNA 17(3): 453--468 Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. [FBrf0212988] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Meyer et al., 2011, J. Cell Sci. 124(12): 1984--1991 Identification of an animal sucrose transporter. [FBrf0213795] Sun et al., 2011, PLoS ONE 6(4): e18215 Systems-scale analysis reveals pathways involved in cellular response to methamphetamine. [FBrf0213560] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...