Please see the JBrowse view of Dmel\Ama for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Gene model reviewed during 5.56
1.5 (northern blot)
333 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ama using the Feature Mapper tool.
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: diffuse localization
The Ama transcript has two major peaks of accumulation during development, one during mid-embryogenesis, and the second during early pupation.
Ama protein is secreted.
Ama protein is first detected in stage 8 embryos in the mesoderm. It begins to accumulate in the midline at late stage 9/early stage 10 and is found in a subset of the mesectodermal cells. At stage 10, Ama protein is observed on cells of the aminoserosa, especially along the border with the dorsal epidermis. Neuronal accumulation is first observed in stage 10, and by stage 13, Ama protein is observed on all of the cell bodies and axons of the CNS. However, no staining of axons is seen after they exit the CNS. Ama protein continues to accumulate in mesodermal derivatives. It is found in the visceral mesoderm in stage 13 and in the fat body and dorsal vessel in stage 16. Ama protein accumulation is observed in a subset of PNS cells starting in stage 13 including the spiracular sensory organ. During stage 16, Ama protein also accumulates on several cephalic sensory structures including the dorsal and terminal organs, the epiphysis and the hypophysis.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ama in GBrowse 23-47
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Ama CG2198
Source for merge of: Ama M109
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
Haploinsufficiency dependent upon an Abl mutant background (HDA).
Encodes a protein of the immunoglobulin super-family that may function as a cell-adhesion protein.