Gene Dmel\CG2650

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General Information

Symbol

Dmel\CG2650

Species

D. melanogaster

Name

CG2650

Annotation symbol

CG2650

Feature type

protein_coding_gene

FlyBase ID

FBgn0000092

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

1-1.2

Cytogenetic map

3B2-3B2

Sequence location

X:2,586,764..2,587,919 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG2650 (FBgn0000092). It has the cytological map location 3B2. Its sequence location is X:2586764..2587919. Its molecular function is unknown. It is involved in the biological process circadian rhythm. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3B2-3B2

Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dnc^EP1395

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-1.2

(Lorenz et al., 1989)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

In direction of increasing cytology: per+ CG2650+ CG2658+ Csat-

(Zehring et al., 1984, Reddy et al., 1984)

Gene Order (overall orientation not stated)

References

Overall orientation not stated: per+ CG2650-

(Lorenz et al., 1989)

Overall orientation not stated: per+ CG2650- CG2658- Csat-

(Gatt and Ashburner, 2000.2.8)

Gene Model & Products

Please see the GBrowse view of Dmel\CG2650 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG2650-RA

FBtr0070504

NM_130660

1014

260

Additional Transcript Data & Comments

Reported size (kB)

0.9 (northern blot)

(Pak et al., 1991, Reddy et al., 1984)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG2650-PA

FBpp0070480

29.2

260

7.45

NP_570016

AAF45805

Additional Polypeptide Data & Comments

Reported size (kD)

261 (aa)

(Pak et al., 1991)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0000092

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Odorant binding protein (IPR004272)

Hormone binding (IPR013053)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

O76879

UniProtKB/TrEMBL

Maps to

155E2

(FlyBase, 1992-)

Does NOT map to

Identified with

RH43234

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

adult stage

(Reddy et al., 1984)

pupal stage

(Reddy et al., 1984)

adult stage

epidermis

(Pak et al., 1991)

adult stage

epidermis

(Pak et al., 1991)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0000092

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0000092

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0000092

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG2650	Class	Mutagen	Stocks	Known lesion
CG2650^T			0	Yes

Alleles Carried on Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG2650	Mutagen	Stocks	Known lesion
CG2650^14.6	in vitro construct \| genomic fragment	0	Yes
CG2650^7.3	in vitro construct \| genomic fragment	0	Yes
CG2650^8.0	in vitro construct \| deletion	0	Yes
CG2650^GD1261	in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)64j4

Useful duplication

Dp(1;2)w⁺70h

Disrupted in

Df(1)64j4

(Lorenz et al., 1989)

Df(1)TEM202

(Lorenz et al., 1989)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD1261}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Encodes 0.9kb RNA adjacent to per.

(Zehring et al., 1984)

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

molecular_function

no biological data available

(FlyBase Curators, 2002-)

Biological Process

CV term

Evidence

References

circadian rhythm

inferred from expression pattern

(Lorenz et al., 1989)

Cellular Component

CV term

Evidence

References

cellular_component

no biological data available

(FlyBase Curators, 2002-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG2650 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

57783

Orthologs

Genome-wide drosophilid orthologs

Dana\GF21371

Dere\GG18615

Dgri\GH12677

Dmoj\GI16254

Dper\GL18241

Dpse\GA15409

Dsec\GM18865

Dsim\GD24605

Dvir\GJ16719

Dwil\GK19974

Dyak\GE16930

Curated drosophilid orthologs

Dpse\GA15409

Dsim\GD24605

Dyak\GE16930

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v42825

w¹¹¹⁸; P{GD1261}v42825

v42828

w¹¹¹⁸; P{GD1261}v42828/CyO

Genomic Clones ( 1 )

BACR30B01

cDNA Clones ( 10 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RH43234

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RH57945

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0000092

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0000092

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: anon-3B1.2 CG2650

(Deng, 1999.11)

Source for database merge of

Additional comments

Comments About Role

The level of CG2650 transcription is strongly modulated during light/dark cycles. CG2650 may be necessary but not sufficient to control arrays of cellular and rhythmic functions.

(Reddy et al., 1984)

CG2650 becomes abundantly expressed during pupation, just prior to eclosion. In situ hybridization localizes the 0.9 kb transcript to the epidermis of newly eclosed adults. This RNA is transcribed from DNA adjacent to per and its expression is under circadian clock control. Expression of CG2650 appears to be under the control of the pupal circadian clock. The transcript is intensely expressed in late pupal development in individuals just hours away from eclosion, levels fall rapidly during the first few hours of adult life. Expression levels decrease with age, not time of day.

(Lorenz et al., 1989)

Comments About Molecular Function

The direction of transcription reported in FBrf0040494 is in error.

(Gatt and Ashburner, 2000.2.8)

Other Comments

Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

(Schmid and Tautz, 1997)

"Gene order: Overall orientation not stated: per+ CG2650- CG2658- Csat-" was stated as revision.

(Gatt and Ashburner, 2000.2.8)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_130660

RefSeq (Proteins)

•

NP_570016

DDBJ / EMBL / GenBank

•