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Gene Dmel\RpLP0

General Information
Symbol	Dmel\RpLP0	Species	D. melanogaster
Name	Ribosomal protein LP0	Annotation symbol	CG7490
Feature type	protein_coding_gene	FlyBase ID	FBgn0000100
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	RpP0, AP3, PO, P0
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	79B2-79B2	Sequence location	3L:22,069,142..22,070,587 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein LP0 is referred to in FlyBase by the symbol Dmel\RpLP0 (CG7490, FBgn0000100). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein 60S; Ribosomal protein L10/acidic P0. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637546_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpLP0. Gene sequence location is 3L:22069142..22070587.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Ape: Apurinic endonuclease Encodes an apurinic-apyrimidinic DNA endonuclease, AP3. Biochemical studies by Spiering and Deutsch (1986, J. Biol. Chem. 261: 3222-28).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Alonso and Santaren, 2006, J. Proteome Res. 5(8): 2025--2032
FB2012_01	Sequence features HFA11878 BKN20294
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 79B2-79B2   Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 79D1-79D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 79D1-79D2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 79C-79D   (determined by in situ hybridisation)   (Kelley et al., 1989)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpLP0 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpLP0-RA FBtr0078481  NM_079487   1261   317
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpLP0-PA   FBpp0078134   34.2   317   6.95     NP_524211   AAF51807
Additional Polypeptide Data & Comments
Reported size (kDa)	317 (aa); 34 (kD) (Grabowski et al., 1991)
Comments	Contains CKI and CKII phosphorylation sites. (Grabowski et al., 1991)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L10/acidic P0 (IPR001790) Ribosomal protein 60S (IPR001813)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202483   AA202807   AA203003   AA246635   AA246903   AA263513   AA263853   AA264057   AA264123   AA390556   AA390683   AA391074   AA392109   AA392873   AA439106   AA440172   AA440371   AA440419   AA440714   AA440968   AA539468   AA539809   AA540622   AA567045   AA567131   AA567169   AA567212   AA567288   AA694739   AA695195   AA695419   AA695611   AA695825   AA696058   AA696225   AA696326   AA696526   AA696536   AA696697   AA696806   AA697058   AA697119   AA697125   AA697188   AA697778   AA698418   AA699102   AA735756   AA735778   AA735879   AA735904   AA735917   AA736009   AA801631   AA801709   AA801770   AA801797   AA801800   AA801915   AA802134   AA802439   AA802990   AA803005   AA803103   AA803228   AA803471   AA803584   AA803652   AA803784   AA803832   AA803988   AA804031   AA816563   AA817459   AA817602   AA821122   AA821155   AA821167   AA941225   AA949679   AA949693   AA950281   AA978762   AA979076   AE014296 AAF51807   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BX036109   BX036158   BX036358   BX036405   BX036428   BX036518   BX036566   BX036630   BX036670   BX036700   BX036715   BX036759   BX036831   BX036889   BX036902   BX037012   BX037106   BX037165   BX037187   BX037189   BX037215   BX037247   BX037276   BX037345   BX037386   BX039262   BX039309   BX039373   BX039734   BX039907   BX040069   BX040137   BX040190   BX040236   BX040297   BX040351   BX040616   BX040799   BX040837   BX040887   BX041108   BX041135   BX041365   BX041389   BX041467   BX041602   BX041651   BX041718   BX041748   BX041799   BX041927   BX042353   BX042404   BX042434   BX042524   BX042609   BX042955   BX043059   BX043090   BX043118   BX043127   BX043251   BX043472   BX043623   BX043649   BX043702   BX043757   BX043798   BX044026   BX044052   BX044085   BX044099   BX044153   BX044159   BX044185   BX044429   BX044588   BX044603   BX044619   BX044735   BX044741   BX044857   BX045040   BX045074   BX045257   BX045267   BX045432   BX045440   BX045497   BX045705   BX046025   BX046099   BX046117   BX046163   BX046290   BX046353   BX046659   BX046679   BX046849   BX047017   BX047157   BX047277   BX047592   BX047691   BX047714   BX047732   BX047734   BX047843   BX047946   BX047999   BX048199   BX048234   BX048433   BX048525   BX048750   BX049187   BX049240   BX049466   BX049524   BX049546   BX049615   BX049674   BX049728   BX049758   BX049856   BX050196   BX050202   BX050212   BX050244   BX050290   BX050412   BX050437   BX050479   BX050514   BX050545   BX050552   BX050679   BX050702   BX050711   BX050723   BX050762   BX050797   BX050804   BX051275   BX051301   BX051379   BX051472   BX051509   BX051577   BX051600   BX051618   BX051626   BX051750   BX051866   BX051899   BX051926   BX051964   BX052006   BX052064   BX052085   BX052235   BX052263   BX052368   BX052724   BX052777   BX052835   BX052874   BX052946   BX052948   BX053131   BX053146   BX053185   BX053214   BX053469   BX053516   BX053532   BX053693   BX053704   BX053751   BX053889   BX054048   BX054114   BX054186   BX054246   BX054345   BX054435   BX054540   BX054654   BX055017   BX055147   BX055567   BX055586   BX055603   BX055621   BX055721   BX055725   BX055808   BX055960   BX055999   BX056283   BX056285   BX056287   BX056320   BX056483   BX056542   BX056754   BX056873   BX056914   BX056958   BX056996   BX057074   BX057094   BX057133   BX057213   BX057218   BX057468   BX057605   BX057631   BX057796   BX057869   BX057924   BX058116   BX058203   BX058315   BX058565   BX058729   BX058740   BX058760   BX058821   BX058839   BX058971   BX059095   BX059184   BX059220   BX059305   BX059469   BX059585   BX059587   BX059602   BX059642   BX059741   BX059758   BX059866   BX059916   BX060185   BX060443   BX060488   BX060527   BX060622   BX060642   BX061042   BX061061   BX061090   BX061098   BX061133   BX061137   BX061163   BX061190   BX061430   BX061878   BX062048   BX062169   BX062183   BX062297   BX062299   BX062387   BX062546   BX062552   BX062791   BX063227   BX063420   BX063434   BX063466   BX063577   BX063872   BX064068   BX064120   BX064164   BX064284   BX064296   BX064423   BX064530   BX064601   BX064725   BX064760   BX064796   BX064952   BX065005   BX065015   BX065042   BX065249   BX065269   BX065334   BX065359   BX065465   BX065713   BX065816   BX066329   BX066390   BX066412   BX066426   BX066597   BX066623   BX066645   BX066836   BX066854   BX066992   BX067179   BX067216   BX067429   BX067487   BX067564   BX067707   BX067752   BX067775   BX067819   BX067841   BX067891   BX067974   BX068019   BX068055   BX068229   BX068471   BX068585   BX068607   BX068760   BX068815   BX068833   BX068988   BX069126   BX069142   BX069235   BX069336   BX069403   BX069588   BX069791   BX069823   BX069968   BX070099   BX070541   BX070589   BX070622   BX070745   BX070751   BX070894   BX070900   BX070930   BX070973   BX071039   BX071175   BX071226   BX071251   BX071318   BX071386   BX071445   BX071518   BX071598   BX071747   BX071847   BX071993   BX072029   BX072031   BX072055   BX072146   BX072148   CA804200   CK132453   CK604279   CK605231   CK605431   CK657325   CK657357   CK658154   CK658218   CK658367   CK658963   CK660033   CK660087   CK660690   CK661718   CO153195   CO155850   CO155928   CO181853   CO181979   CO183279   CO184168   CO184382   CO190780   CO193295   CO194283   CO194649   CO195264   CO282037   CO282459   CO283232   CO284313   CO291160   CO296292   CO304874   CO312821   CO335931   CO336220   CR937950   CR937956   CR938080   CR938110   CR938249   CR938482   CR938511   CR938539   CR938612   CR938653   CR938661   CR938688   CZ476812   CZ476813   DN154504   DQ440195   EC058094   EC059114   EC065765   EC085040   EC086110   EC201549   EC224294   EC245357   EC248402   EC261378   EC262983   EC263234   EC265272   EC265427   EC265685   EC267541   EL877766   EL877886   EL878018   EL878121   EL879102   EL880867   EL884339   EL884457   EL885425   EL885537   EL885769   ES688765   EV575660   EV581759   EV582648   EV586722   EV587037   EV587740   EV588756   EV600230   EV600551   EV600560   GH748474   GH749789   GH754671   GH756713   GH760395   GH761087   GH770330   GH772808   GH773433   GH773464   GH775548   GH776815   GH778968   GH780892   GH787388   GH787534   GH788539   GH793828   GH797142   GH797308   GH797870   GH798023   GH800189   GH801316   GH804227   GH804309   GH804659   GH806522   GH806718   GH809443   GH809780   GH810231   GH811953   GH815983   GH818077   GH820857   GH828850   GH833599   GH834563   GH835542   GH836276   GH840059   GH841210   GH845985   GH846119   GH847370   GH848456   GH852028   GH856050   GH857570   GH858336   GH862372   GH862542   GH863070   GH864678   GH865350   GH865562   GH871348   GH872954   GH875873   GH876422   GH876954   GH879111   GH880025   GH880466   GH881603   GH883625   GH888145   GH888930   GH892690   GH894816   GH895795   GH896673   GH897449   GH898667   GH899768   GH905707   GH907078   GH907500   GH913207   GH915691   GH915787   GH923295   GH923498   GH928406   GH928964   GH929032   GH930504   GH930967   GH931120   GH934160   GH936880   M25772 AAA53372
UniProtKB/Swiss-Prot	P19889
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000100    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000100 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000100 expression level Developmental Stage   Expression Level embryo 00-02hr    92811 embryo 02-04hr    135367 embryo 04-06hr    111512 embryo 06-08hr    103015 embryo 08-10hr    113340 embryo 10-12hr    161050 embryo 12-14hr    88828 embryo 14-16hr    123267 embryo 16-18hr    107049 embryo 18-20hr    125619 embryo 20-22hr    129742 embryo 22-24hr    109415 larva L1    180205 larva L2    158941 larva L3 12hr old    134441 larva L3 puffstage 1-2    99046 larva L3 puffstage 3-6    92317 larva L3 puffstage 7-9    88703 white prepupae new    77494 white prepupae 12hr    60640 white prepupae 24hr    65482 pupae 2d postWPP    59619 pupae 3d postWPP    51761 pupae 4d postWPP    56107 adult male 01day    47105 adult male 05day    52231 adult male 30day    56936 adult female 01day    125260 adult female 05day    118651 adult female 30day    127274 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    92811 embryo 02-04hr    135367 embryo 04-06hr    111512 embryo 06-08hr    103015 embryo 08-10hr    113340 embryo 10-12hr    161050 embryo 12-14hr    88828 embryo 14-16hr    123267 embryo 16-18hr    107049 embryo 18-20hr    125619 embryo 20-22hr    129742 embryo 22-24hr    109415 larva L1    180205 larva L2    158941 larva L3 12hr old    134441 larva L3 puffstage 1-2    99046 larva L3 puffstage 3-6    92317 larva L3 puffstage 7-9    88703 white prepupae new    77494 white prepupae 12hr    60640 white prepupae 24hr    65482 pupae 2d postWPP    59619 pupae 3d postWPP    51761 pupae 4d postWPP    56107 adult male 01day    47105 adult male 05day    52231 adult male 30day    56936 adult female 01day    125260 adult female 05day    118651 adult female 30day    127274 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000100 expression level Developmental Stage   Expression Level embryo 00-02hr    92811 embryo 02-04hr    135367 embryo 04-06hr    111512 embryo 06-08hr    103015 embryo 08-10hr    113340 embryo 10-12hr    161050 embryo 12-14hr    88828 embryo 14-16hr    123267 embryo 16-18hr    107049 embryo 18-20hr    125619 embryo 20-22hr    129742 embryo 22-24hr    109415 larva L1    180205 larva L2    158941 larva L3 12hr old    134441 larva L3 puffstage 1-2    99046 larva L3 puffstage 3-6    92317 larva L3 puffstage 7-9    88703 white prepupae new    77494 white prepupae 12hr    60640 white prepupae 24hr    65482 pupae 2d postWPP    59619 pupae 3d postWPP    51761 pupae 4d postWPP    56107 adult male 01day    47105 adult male 05day    52231 adult male 30day    56936 adult female 01day    125260 adult female 05day    118651 adult female 30day    127274 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (92811) embryo 02-04hr  (135367) embryo 04-06hr  (111512) embryo 06-08hr  (103015) embryo 08-10hr  (113340) embryo 10-12hr  (161050) embryo 12-14hr  (88828) embryo 14-16hr  (123267) embryo 16-18hr  (107049) embryo 18-20hr  (125619) embryo 20-22hr  (129742) embryo 22-24hr  (109415) larva L1  (180205) larva L2  (158941) larva L3 12hr old  (134441) larva L3 puffstage 1-2  (99046) larva L3 puffstage 3-6  (92317) larva L3 puffstage 7-9  (88703) white prepupae new  (77494) white prepupae 12hr  (60640) white prepupae 24hr  (65482) pupae 2d postWPP  (59619) pupae 3d postWPP  (51761) pupae 4d postWPP  (56107) adult male 01day  (47105) adult male 05day  (52231) adult male 30day  (56936) adult female 01day  (125260) adult female 05day  (118651) adult female 30day  (127274) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    92811 embryo 02-04hr    135367 embryo 04-06hr    111512 embryo 06-08hr    103015 embryo 08-10hr    113340 embryo 10-12hr    161050 embryo 12-14hr    88828 embryo 14-16hr    123267 embryo 16-18hr    107049 embryo 18-20hr    125619 embryo 20-22hr    129742 embryo 22-24hr    109415 larva L1    180205 larva L2    158941 larva L3 12hr old    134441 larva L3 puffstage 1-2    99046 larva L3 puffstage 3-6    92317 larva L3 puffstage 7-9    88703 white prepupae new    77494 white prepupae 12hr    60640 white prepupae 24hr    65482 pupae 2d postWPP    59619 pupae 3d postWPP    51761 pupae 4d postWPP    56107 adult male 01day    47105 adult male 05day    52231 adult male 30day    56936 adult female 01day    125260 adult female 05day    118651 adult female 30day    127274 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000100    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000100 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000100 expression level Tissue   Expression Level Larval Central Nervous System    2951.675 Larval Midgut    4502.4 Larval Hindgut    4562.7 Larval Malpighian Tubules    4869.2 Larval Fat Body    8487.6 Larval Salivary Gland    7889.2 Larval Trachea    6413 Larval Carcass    4853.6 Adult Head    4712.6 Adult Eye    5523.825 Adult Brain    3008.3 Adult Thoracic-Abdominal Ganglion    3891.2 Adult Crop    6556.4 Adult Midgut    5077.5 Adult Hindgut    5280 Adult Malpighian Tubules    5919.8 Adult Fat Body    6184.7 Adult Salivary Gland    9254.5 Adult Heart    6325 Adult VirginFemale Spermatheca    6116.8 Adult InseminatedFemale Spermatheca    6418.4 Adult Ovary    3672.1 Adult Testis    1022 Adult Male Accessory Gland    9187.4 Adult Carcass    5674.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2951.675) Larval Midgut  (4502.4) Larval Hindgut  (4562.7) Larval Malpighian Tubules  (4869.2) Larval Fat Body  (8487.6) Larval Salivary Gland  (7889.2) Larval Trachea  (6413) Larval Carcass  (4853.6) Adult Head  (4712.6) Adult Eye  (5523.825) Adult Brain  (3008.3) Adult Thoracic-Abdominal Ganglion  (3891.2) Adult Crop  (6556.4) Adult Midgut  (5077.5) Adult Hindgut  (5280) Adult Malpighian Tubules  (5919.8) Adult Fat Body  (6184.7) Adult Salivary Gland  (9254.5) Adult Heart  (6325) Adult VirginFemale Spermatheca  (6116.8) Adult InseminatedFemale Spermatheca  (6418.4) Adult Ovary  (3672.1) Adult Testis  (1022) Adult Male Accessory Gland  (9187.4) Adult Carcass  (5674.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2951.675) Larval Midgut  (4502.4) Larval Hindgut  (4562.7) Larval Malpighian Tubules  (4869.2) Larval Fat Body  (8487.6) Larval Salivary Gland  (7889.2) Larval Trachea  (6413) Larval Carcass  (4853.6) Adult Head  (4712.6) Adult Eye  (5523.825) Adult Brain  (3008.3) Adult Thoracic-Abdominal Ganglion  (3891.2) Adult Crop  (6556.4) Adult Midgut  (5077.5) Adult Hindgut  (5280) Adult Malpighian Tubules  (5919.8) Adult Fat Body  (6184.7) Adult Salivary Gland  (9254.5) Adult Heart  (6325) Adult VirginFemale Spermatheca  (6116.8) Adult InseminatedFemale Spermatheca  (6418.4) Adult Ovary  (3672.1) Adult Testis  1022 Adult Male Accessory Gland  (9187.4) Adult Carcass  (5674.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2951.675 Larval Midgut    4502.4 Larval Hindgut    4562.7 Larval Malpighian Tubules    4869.2 Larval Fat Body    8487.6 Larval Salivary Gland    7889.2 Larval Trachea    6413 Larval Carcass    4853.6 Adult Head    4712.6 Adult Eye    5523.825 Adult Brain    3008.3 Adult Thoracic-Abdominal Ganglion    3891.2 Adult Crop    6556.4 Adult Midgut    5077.5 Adult Hindgut    5280 Adult Malpighian Tubules    5919.8 Adult Fat Body    6184.7 Adult Salivary Gland    9254.5 Adult Heart    6325 Adult VirginFemale Spermatheca    6116.8 Adult InseminatedFemale Spermatheca    6418.4 Adult Ovary    3672.1 Adult Testis    1022 Adult Male Accessory Gland    9187.4 Adult Carcass    5674.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000100 expression level Tissue   Expression Level Larval Central Nervous System    2951.675 Larval Midgut    4502.4 Larval Hindgut    4562.7 Larval Malpighian Tubules    4869.2 Larval Fat Body    8487.6 Larval Salivary Gland    7889.2 Larval Trachea    6413 Larval Carcass    4853.6 Adult Head    4712.6 Adult Eye    5523.825 Adult Brain    3008.3 Adult Thoracic-Abdominal Ganglion    3891.2 Adult Crop    6556.4 Adult Midgut    5077.5 Adult Hindgut    5280 Adult Malpighian Tubules    5919.8 Adult Fat Body    6184.7 Adult Salivary Gland    9254.5 Adult Heart    6325 Adult VirginFemale Spermatheca    6116.8 Adult InseminatedFemale Spermatheca    6418.4 Adult Ovary    3672.1 Adult Testis    1022 Adult Male Accessory Gland    9187.4 Adult Carcass    5674.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2951.675) Larval Midgut  (4502.4) Larval Hindgut  (4562.7) Larval Malpighian Tubules  (4869.2) Larval Fat Body  (8487.6) Larval Salivary Gland  (7889.2) Larval Trachea  (6413) Larval Carcass  (4853.6) Adult Head  (4712.6) Adult Eye  (5523.825) Adult Brain  (3008.3) Adult Thoracic-Abdominal Ganglion  (3891.2) Adult Crop  (6556.4) Adult Midgut  (5077.5) Adult Hindgut  (5280) Adult Malpighian Tubules  (5919.8) Adult Fat Body  (6184.7) Adult Salivary Gland  (9254.5) Adult Heart  (6325) Adult VirginFemale Spermatheca  (6116.8) Adult InseminatedFemale Spermatheca  (6418.4) Adult Ovary  (3672.1) Adult Testis  (1022) Adult Male Accessory Gland  (9187.4) Adult Carcass  (5674.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2951.675) Larval Midgut  (4502.4) Larval Hindgut  (4562.7) Larval Malpighian Tubules  (4869.2) Larval Fat Body  (8487.6) Larval Salivary Gland  (7889.2) Larval Trachea  (6413) Larval Carcass  (4853.6) Adult Head  (4712.6) Adult Eye  (5523.825) Adult Brain  (3008.3) Adult Thoracic-Abdominal Ganglion  (3891.2) Adult Crop  (6556.4) Adult Midgut  (5077.5) Adult Hindgut  (5280) Adult Malpighian Tubules  (5919.8) Adult Fat Body  (6184.7) Adult Salivary Gland  (9254.5) Adult Heart  (6325) Adult VirginFemale Spermatheca  (6116.8) Adult InseminatedFemale Spermatheca  (6418.4) Adult Ovary  (3672.1) Adult Testis  1022 Adult Male Accessory Gland  (9187.4) Adult Carcass  (5674.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2951.675 Larval Midgut    4502.4 Larval Hindgut    4562.7 Larval Malpighian Tubules    4869.2 Larval Fat Body    8487.6 Larval Salivary Gland    7889.2 Larval Trachea    6413 Larval Carcass    4853.6 Adult Head    4712.6 Adult Eye    5523.825 Adult Brain    3008.3 Adult Thoracic-Abdominal Ganglion    3891.2 Adult Crop    6556.4 Adult Midgut    5077.5 Adult Hindgut    5280 Adult Malpighian Tubules    5919.8 Adult Fat Body    6184.7 Adult Salivary Gland    9254.5 Adult Heart    6325 Adult VirginFemale Spermatheca    6116.8 Adult InseminatedFemale Spermatheca    6418.4 Adult Ovary    3672.1 Adult Testis    1022 Adult Male Accessory Gland    9187.4 Adult Carcass    5674.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4712.6   NA  Eye    5523.825   NA  Brain    3008.3   2951.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3891.2   NA  Crop    6556.4   4502.4  Midgut    5077.5   4562.7  Hindgut    5280   4869.2  Malpighian Tubules    5919.8   8487.6  Fat Body    6184.7   7889.2  Salivary Gland    9254.5   NA  Heart    6325   6413  Trachea    NA   NA  VirginFemale Spermatheca    6116.8   NA  InseminatedFemale Spermatheca    6418.4   NA  Ovary    3672.1   NA  Testis    1022   NA  Male Accessory Gland    9187.4   4853.6  Carcass    5674.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000100 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7490-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 RpLP0GD13189 lethal | recessive RpLP001544 Other Phenotypes Allele non-suppressor of variegation, with In(1)wm4h RpLP0306 suppressor of variegation | dominant, with In(1)wm4h RpLP001544 wild-type RpLP0rev Phenotype manifest in Allele
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of RpLP0 Class Mutagen Stocks Known lesion RpLP0NP2385 2 -- RpLP001544 hypermorphic allele - genetic evidence, gain of function allele P-element activity 1 Yes RpLP0c05892 1 -- RpLP0d09567 P-element activity 1 -- RpLP0DP00460 1 -- RpLP0UM-8046-3 1 -- RpLP0306 loss of function allele Delta2-3 0 Yes RpLP036 Delta2-3 0 Yes RpLP08 Delta2-3 0 Yes RpLP0rev wild-type allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpLP0 Class Mutagen Stocks Known lesion RpLP0GD13189 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RpLP0JF01335 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)Pc (BDGP Project Members, 1994-1999) Df(3L)Pc-MK (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3L)BSC223 (Gresens and Cook, 2006.12.5)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13189} NA P{TRiP.JF01335} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}RpLP001544 No miscellaneous insertions P{5'3'}RpLP08 NA P{5'3'}RpLP036 NA P{RS3}RpLP0UM-8046-3 NA PBac{PB}RpLP0c05892 NA insertion of enhancer trap binary system P{GawB}RpLP0NP2385 No insertion of mobile activating element P{Mae-UAS.6.11}RpLP0DP00460 NA P{XP}RpLP0d09567 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006) ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
DNA-(apurinic or apyrimidinic site) lyase activity non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) structural constituent of ribosome inferred from sequence or structural similarity with UniProtKB:Q9U3U0 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1991.2.1)
Biological Process
CV term Evidence References
DNA repair non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) ribosome biogenesis inferred from electronic annotation with InterPro:IPR001790 (FlyBase Curators et al., 2004-) translation inferred from sequence or structural similarity with UniProtKB:Q9U3U0 (FlyBase, 1992-) translational elongation inferred from electronic annotation with InterPro:IPR001813 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) cytosolic large ribosomal subunit inferred from sequence or structural similarity with UniProtKB:Q9U3U0 (FlyBase, 1992-) nucleus non-traceable author statement (Swiss-Prot Project Members, 1991.2.1) ribosome non-traceable author statement (Swiss-Prot Project Members, 1991.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpLP0 allele Gene References RpLP0306 fs(1)Ya (Yu et al., 2002) RpLP001544 w (Frolov and Birchler, 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65690 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000100 DroID - A comprehensive database of gene and protein interactions. • FBgn0000100 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40451
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10946 Dere\GG16244 Dgri\GH14667 Dmoj\GI13777 Dpse\GA20389 Dsec\GM22429 Dsim\GD15019 Dvir\GJ13582 Dwil\GK20443 Dyak\RpLP0
Curated drosophilid orthologs	Dpse\GA20389   Dvir\RpLP0 (Schulze et al., 2006) Dyak\RpLP0
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010821-PA Aedes aegypti (mosquito) AGAP003592-PA Anopheles gambiae (mosquito) XP_623106.1 Apis mellifera (honey bee) NP_001119687.1 Acyrthosiphon pisum (pea aphid) At3g11250.1 Arabidopsis thaliana (wall cress) 15859 Batrachochytrium dendrobatidis (chytrid fungus) 109886 Branchiostoma floridae (lancelet) 97880 Branchiostoma floridae (lancelet) XP_001897742.1 Brugia malayi (roundworm nematode) BGIBMGA003309-PA Bombyx mori (silk worm) ENSBTAP00000048183 Bos taurus (bovine) CAL0001932 Candida albicans (a form of yeast) CN11724 Caenorhabditis brenneri (small nematode) CBP06250 Caenorhabditis briggsae (nematode) CE09655 Caenorhabditis elegans (worm) ENSCAFP00000014512 Canis familiaris (dog) ENSCAFP00000015013 Canis familiaris (dog) CAGL0G00990g Candida glabrata (haploid yeast) Chro.40257 Cryptosporidium hominis (obligate parasite) ENSCINP00000008143 Ciona intestinalis (sea squirt) JA07614 Caenorhabditis japonica (nematode) CMQ445C Cyanidioschyzon merolae (red alga) cn07449 Cryptococcus neoformans (yeast-like fungus) cgd4_2260 Cryptosporidium parvum (protozoan parasite) CPIJ009501 Culex pipens (mosquito) ENSCPOP00000016687 Cavia porcellus (guinea pig) 164097 Chlamidomonas reinhardtii (green alga) RP44410 Caenorhabditis remanei (nematode) ENSCSAVP00000010503 Ciona savignyi (sedentary tunicate) 167366 Capitella spl (polychaete worm) DDB0219977 Dictyostelium discoideum (amoeba) DEHA2F22242g Debaryomyces Hansenii (yeast) 307348 Daphnia pulex (daphnia) ENSDARP00000067953 Danio rerio (zebra fish) XP_001913560 Entamoeba histolytica (anaerobic protozoan) XP_649340 Entamoeba histolytica (anaerobic protozoan) XP_655933 Entamoeba histolytica (anaerobic protozoan) XP_657581 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011305 Gymnopilus aculeatus (mushroom) ENSGALP00000011717 Gallus gallus (chicken) GL50803_17054 Giardia lamblia (flagellated protozoan) 185645 Hypsipyla robusta (cedar shoot borer) ENSP00000339027 Homo sapiens (human) ISCW007303-PA Ixodes scapularis (deer tick) KLLA0B05918g Kluyveromyces lactis (yeast) 237709 Lottia gigantea (owl limpet) LmjF27.1380 Leishmania major (virus) LmjF27.1390 Leishmania major (virus) 18498 Monocosta brevicollis (choanoflagellate) ENSMODP00000018997 Monodelphis domestica (gray opossum) ENSMMUP00000012008 Macaca mulatta (rhesus monkey) ENSMUSP00000083705 Mus musculus (house mouse) 237425 Nematostella vectensis (starlet anemone) XP_001607606.1 Nasonia vitripennis (wasp) ENSOANP00000010417 Ornithorynchus anatinus (platypus) ENSORLP00000011508 Oryzias latipes (japanese killifish) LOC_Os08g03640.1 Oryza sativa (asian rice) LOC_Os11g04070.1 Oryza sativa (asian rice) LOC_Os12g03880.1 Oryza sativa (asian rice) 23034 Ostreococcus tauri (green alga) PF11_0313 Plasmodium falciparum (protozoal parasite) PHUM003529-PA Pediculus humanus (human body louse) PP09266 Pristionchus pacificus (nematode) 180102 Physcomitrella patens (moss) ENSPPYP00000005724 Pongo pygmaeus (orangutan) 71544 Phytophthora ramorum (sudden oak death pathogen) 109515 Phytophthora sojae (root rot pathogen) 822404 Populus trichocarpa (black cottonwood) ENSPTRP00000009378 Pan troglodytes (chimpanzee) PVX_092120 Plasmodium vivax (protozoal parasite) ENSRNOP00000001518 Rattus norvegicus (norway rat) 5058361 Sorghum bicolor (sorghum) YLR340W Saccharomyces cerevisiae (budding yeast) Smp_009690.1 Schistosoma mansoni (trematode parasite) SPCC18.14c Schizosaccharomyces pombe (fission yeast) 63360 Trichoplax adhaerens (metazoa) TA21355 Theileria annulata (apicomplexan parasite) XP_975936.1 Tribolium castaneum (red flour beetle) Tc00.1047053508355.250 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508355.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013936 Tetraodon nigroviridis (green spotted pufferfish) TP01_0294 Theileria parva (parasitic protozoan) 25812 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040545 Takifugu rubripes (pufferfish Takifugu) 91.m00115 Tetrahymena thermophila (ciliate protozoa) 82012.m00128 Trichomonas vaginalis (parasitic flagellated protozoan) 85714.m00051 Trichomonas vaginalis (parasitic flagellated protozoan) 86633.m00157 Trichomonas vaginalis (parasitic flagellated protozoan) 92204.m00046 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000041250 Xenopus tropicalis (frog) YALI0B14146g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16486 PB13254 NV11446 LH21470 ISCW007303 FBgn0068063 FBgn0222440 FBgn0200805 FBgn0186691 FBgn0177299 JGI_V11_307348 FBgn0080384 FBgn0136532 FBgn0122143 FBgn0108479 FBgn0087986 CPIJ009501 BGIBMGA003309 ACYPI000079 GB12338 AGAP003592 AAEL010821 PHUM168440 GLEAN_16306
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	31370 y1 v1; P{TRiP.JF01335}attP2/TM3, Ser1 22053 y1 w67c23; P{Mae-UAS.6.11}RpLP0DP00460 11537 P{PZ}RpLP001544 ry506/TM3, ryRK Sb1 Ser1
Harvard	- P{XP}RpLP0d09567 - PBac{PB}RpLP0c05892
Kyoto	124305 w1118; P{RS3}RpLP0UM-8046-3 104183 w*; P{GawB}RpLP0NP2385 / TM3, Sb1 Ser1 112907 w*; P{GawB}RpLP0NP2385 / TM3, Sb1 Ser1
VDRC	v28619 w1118; P{GD13189}v28619 v28618 w1118; P{GD13189}v28618/TM3
Genomic Clones ( 2 )
	BACR17D14 BACR23D16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 754 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01513 RE74511
Other clones	DPiM_RE74511 yak-em_RpP0
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10321 AT10746 AT24054 GH01617 GH02053 GH02153 GH03413 GH03750 GH04142 GH05027 GH05875 GH06043 GH06729 GH08704 GH11041 GH12926 GH13482 GH14540 GH14792 GH19581 GH20555 GH20892 GH26190 GH26695 GH26785 GH28329 GM01013 GM01173 GM01341 GM02026 GM02795 GM03123 GM03906 GM04549 GM04978 GM06765 GM07003 GM07459 GM07833 GM07845 GM08188 GM08434 GM09140 GM09753 GM10026 GM10073 GM10101 GM12958 GM13031 GM13036 GM13252 GM13794 GM14263 GM14632 GM14723 GM16054 GM16515 GM17610 GM19280 GM19743 GM20521 GM21347 GM24270 GM25577 GM26312 GM26943 GM27211 GM27424 GM29084 GM29291 GM29720 GM29930 GM30380 GM32290 HL03140 HL04458 HL04540 HL07477 LD01004 LD01970 LD02104 LD03125 LD03568 LD05556 LD05913 LD07440 LD07714 LD09465 LD09773 LD12012 LD12467 LD12787 LD13571 LD14779 LD14952 LD15012 LD15579 LD17614 LD19063 LD20369 LD22922 LD23584 LD25252 LD29671 LD32917 LD33338 LD35940 LD36150 LD37425 LD37462 LD37659 LD40173 LD42696 LD43013 LD44575 LD44707 LD45374 LD48088 LP02279 LP02387 LP02989 LP03502 LP03725 LP03849 LP06185 LP07068 LP07470 LP08172 LP08315 LP08606 LP08976 LP09338 LP10469 LP12493 LP13987 LP14778 LP14983 LP15245 LP16317 LP18252 LP19485 LP21384 LP23574 RE03462 RE09714 RE14648 RE46495 RE67244 RH03345 RH04091 RH56086 SD01529 SD02165 SD02218 SD02394 SD03583 SD04356 SD05924 SD06364 SD06387 SD06755 SD07204 SD07754 SD08805 SD08905 SD09132 SD09902 SD10032 SD11985 SD12277 SD13524 SD13947 SD14557 SD15751 SD16189 SD16243 SD16527 SD18072 SD18917 SD19038 SD20378 SD21257 SD21592 SD21755 SD22472 SD22564 SD23968 SD24121 SD24573 SD24739 SD27376 SD27668 SD27868
Other clones	43612 45142 64051 74183 78034 105182 123985 522157 524907 525639 525738 542865 557120 569839 AT08040 AT10384 AT10846 AT14512 AT30071 CK01.61D.F7 CK01.98D.A4 Dmel_dig_006843_0712_1058 Dmel_dig_009015_0611_2180 Dmel_dig_016110_0633_3330 Dmel_neb_004479_0141_1461 Dmel_neb_010642_0089_0434 Dmel_neb_011845_0866_2006 Dmel_neb_012195_0172_1171 Dmel_neb_013598_0896_2368 Dmel_neb_014147_0867_0964 Dmel_neb_014363_0107_2190 EC15104 EC18147 EC25362 EC27262 EC28014 EC35547 EC37762 EC38962 EC39949 EK049624 EK076334 EK159401 EK160531 EK162641 EK165744 EK213320 EK230113 EK246622 EN01453 EN06142 EN06844 EN07038 EN11517 EN12064 ESG0112c.B21_B10 FGH119A02 FGM001A12 FGM003F10 FGM004D07 FGM211E06 FGM212B12 FGM217C08 FGM217C12 FGM220E03 FGM229C06 FGM230G04 FGM231D11 FGM231E06 FGM232D03 FGM232G09 FGM235F03 FGM236H12 FGM307B10 FGM307D07 FGM308C12 FGM308D05 GH04878 GH14413 GH24543 GH24735 GM01196 GM01442 GM02274 GM02387 GM03367 GM03578 GM05327 GM05555 GM06729 GM09021 GM09120 GM09403 GM09837 GM10278 GM10429 GM12470 GM12586 GM13557 GM14378 GM14770 GM16424 GM18215 GM18660 GM19080 GM19683 GM19788 GM22251 GM23006 GM24590 GM29648 GM29652 GM30417 GM31396 IP07735 IP07835 IP07935 IP08023 IP09038 IP10703 IP15652 IP15752 IP16817 IP16917 IP17117 LD06627 LD06924 LD09932 LD28786 LD29655 LD40265 LP02091 LP03886 LP10741 LP18342 LP23527 RE01539 RE02170 RE02182 RE02475 RE02983 RE03428 RE04049 RE05160 RE05868 RE06467 RE06662 RE07194 RE08439 RE08503 RE09763 RE10334 RE10581 RE10907 RE11165 RE13219 RE13453 RE14633 RE15141 RE15193 RE15451 RE15515 RE17379 RE17594 RE17944 RE19052 RE19255 RE20386 RE20982 RE20988 RE21938 RE22128 RE24517 RE24609 RE29924 RE30441 RE31358 RE33127 RE34358 RE34416 RE34421 RE34501 RE35232 RE36384 RE36622 RE36653 RE37773 RE38418 RE38518 RE38702 RE38786 RE38837 RE39401 RE39428 RE39748 RE39855 RE41176 RE41837 RE42274 RE43046 RE43164 RE43274 RE43279 RE43307 RE43885 RE43913 RE44506 RE44559 RE46202 RE46612 RE47865 RE47886 RE48180 RE48304 RE49927 RE50180 RE54160 RE57664 RE58070 RE61083 RE62267 RE63385 RE63522 RE63605 RE63885 RE64315 RE64712 RE65164 RE65939 RE66290 RE66511 RE66809 RE66824 RE68044 RE69215 RE69481 RE71017 RE71643 RE71757 RE72343 RE72454 RE72646 RE72653 RE73690 RE73942 RE74024 RE74402 RE74824 RE74970 RE74996 RH01375 RH01441 RH01622 RH01795 RH01922 RH01965 RH02580 RH02983 RH03064 RH03088 RH03108 RH03493 RH03617 RH04009 RH04039 RH04177 RH04282 RH04319 RH04341 RH04359 RH04363 RH04936 RH05001 RH05019 RH05327 RH05374 RH05417 RH05558 RH05820 RH05912 RH06226 RH06265 RH06628 RH06706 RH06817 RH06860 RH06923 RH07460 RH07469 RH07473 RH07561 RH07661 RH08195 RH08350 RH08550 RH08584 RH08781 RH08941 RH09034 RH09076 RH09256 RH09654 RH09670 RH10983 RH12445 RH12752 RH12765 RH12881 RH13813 RH14158 RH14402 RH15337 RH17350 RH17975 RH18013 RH20715 RH21604 RH21631 RH22331 RH22794 RH22908 RH22923 RH23044 RH23430 RH23807 RH24076 RH26564 RH26842 RH26958 RH27084 RH27477 RH29382 RH30081 RH30558 RH30693 RH30744 RH31247 RH32538 RH34020 RH34315 RH34586 RH35047 RH35072 RH35108 RH35177 RH35416 RH35428 RH35715 RH35932 RH36139 RH36451 RH36823 RH37445 RH37963 RH38010 RH38151 RH38277 RH38432 RH39015 RH39074 RH39906 RH39934 RH40603 RH41839 RH41876 RH43304 RH43775 RH44613 RH44754 RH44993 RH45253 RH45348 RH45887 RH46474 RH46779 RH47495 RH47756 RH48720 RH49155 RH49356 RH51243 RH51325 RH51612 RH51753 RH51785 RH52215 RH52539 RH52743 RH53811 RH54025 RH54131 RH54150 RH54224 RH54252 RH54775 RH55059 RH55272 RH55453 RH55808 RH55964 RH56339 RH56344 RH56462 RH56749 RH57534 RH57735 RH58879 RH58968 RH59148 RH59549 RH60537 RH60819 RH61031 RH61072 RH61080 RH61617 RH62433 RH62956 RH62964 RH63312 RH63563 RH63954 RH64038 RH64448 RH64736 RH64758 RH65678 RH65778 RH66043 RH66439 RH66582 RH66612 RH67490 RH67815 RH68251 RH68485 RH68578 RH68582 RH69702 RH69764 RH70228 RH70311 RH70783 RH71038 RH71666 RH71889 RH72152 RH73302 RH74142 RP003010257 RP003021401 RP003027871 RP003031785 RP003032364 RP003035523 RP003046917 RP003071951 RP003079394 RP003079448 RP003086410 RP003090286 RP003095990 RP003103339 RP003109657 RP003110206 RP003119208 RP003121199 RP003125923 RP003133371 RP003157997 RP003160179 RP003161542 RP003164376 RP003168042 RP003171481 RP003191808 RP003195756 RP003199129 RP003201885 RP003203597 RP003204083 RP003205192 RP003207003 RP003227895 RP003239024 RP003240248 RP003245140 RP003253915 RP003257399 RP003268790 RP003275667 RP003288313 RP003296199 RP003335381 RP003337818 RP003340263 RP003343800 RP003351265 RP003353769 RP003374315 RP003383901 RP003407407 RP003412978 RP003415955 RP003423738 RP003424354 RP003425481 RP003428647 RP003431663 RP003434386 RP003438435 RP003457766 RP003458683 RP003460668 RP003460961 RP003465910 RP003469368 RP003523573 RP003524378 RP003526064 RP003533987 RP003537695 RP003545998 RP003557900 RP003561020 RP003563018 RP003588034 RP003588478 RP003600467 RP003601376 RP003602727 RP003618747 RP003622900 RP003639518 RP003640119 RP003640385 RP003644548 RP003649935 RP003657052 RP003667555 RP003672884 SD09095 SD12286 SD12492 SD12896 SD14174 SD14590 SD15252 SD22230 SD22763 SD24145 SD24467 SD26817 UT01057 UT01774 UT01929 UUGC0412
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000100 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40451
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: RpP0 l(3)01544 (Frolov and Birchler, 1998)
Additional comments
Other Comments
	Not a Minute gene. (Marygold et al., 2007) Deletions removing RpLP0 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes. (Marygold et al., 2007) Molecularly-defined mutations in RpLP0 do not result in Minute phenotypes. (Marygold et al., 2007) The RpLP0 containing 20S cytoplasmic complex may retain hyperphosphorylated ovarian fs(1)Ya in the cytoplasm. (Yu et al., 2002) RpLP0 is a general modifier of PEV, as well as a modifier of gene expression from the w locus. (Frolov and Birchler, 1998) RpLP0 acts on abasic DNA, a lesion known to block DNA replication and case mutations in E.coli. RpLP0 also contains vigorous DNase activity for both single- and double-stranded DNA. RpLP0 can be found in the nucleus tightly associated with the nuclear matrix. (Yacoub et al., 1996) Isolated from a cDNA expression library using antiserum directed against human enzyme known to cross react with the Drosophila enzyme (FBrf0044682).   Encodes an apurinic-apyrimidinic DNA endonuclease, AP3.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079487 RefSeq (Proteins) • NP_524211 DDBJ / EMBL / GenBank • AA695195 AAA53372 AAF51807 AAL68335 AAX33595 AQ026171 AY075528 BI580331 BT021447 CZ476812 CZ476813 M25772 Entrez Gene - A searchable database of RefSeq genes. • 40451 UniProtKB/Swiss-Prot • P19889
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L10/acidic P0 (IPR001790) Ribosomal protein 60S (IPR001813)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65690 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000100 DroID - A comprehensive database of gene and protein interactions. • FBgn0000100 DRSC - Results from RNAi screens. • FBgn0000100 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000100 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7490-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000100 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40451 InParanoid A subset of ortholog calls from InParanoid. • AAEL010821-PA Aedes aegypti (mosquito) AGAP003592-PA Anopheles gambiae (mosquito) XP_623106.1 Apis mellifera (honey bee) NP_001119687.1 Acyrthosiphon pisum (pea aphid) At3g11250.1 Arabidopsis thaliana (wall cress) 15859 Batrachochytrium dendrobatidis (chytrid fungus) 109886 Branchiostoma floridae (lancelet) 97880 Branchiostoma floridae (lancelet) XP_001897742.1 Brugia malayi (roundworm nematode) BGIBMGA003309-PA Bombyx mori (silk worm) ENSBTAP00000048183 Bos taurus (bovine) CAL0001932 Candida albicans (a form of yeast) CN11724 Caenorhabditis brenneri (small nematode) CBP06250 Caenorhabditis briggsae (nematode) CE09655 Caenorhabditis elegans (worm) ENSCAFP00000014512 Canis familiaris (dog) ENSCAFP00000015013 Canis familiaris (dog) CAGL0G00990g Candida glabrata (haploid yeast) Chro.40257 Cryptosporidium hominis (obligate parasite) ENSCINP00000008143 Ciona intestinalis (sea squirt) JA07614 Caenorhabditis japonica (nematode) CMQ445C Cyanidioschyzon merolae (red alga) cn07449 Cryptococcus neoformans (yeast-like fungus) cgd4_2260 Cryptosporidium parvum (protozoan parasite) CPIJ009501 Culex pipens (mosquito) ENSCPOP00000016687 Cavia porcellus (guinea pig) 164097 Chlamidomonas reinhardtii (green alga) RP44410 Caenorhabditis remanei (nematode) ENSCSAVP00000010503 Ciona savignyi (sedentary tunicate) 167366 Capitella spl (polychaete worm) DDB0219977 Dictyostelium discoideum (amoeba) DEHA2F22242g Debaryomyces Hansenii (yeast) 307348 Daphnia pulex (daphnia) ENSDARP00000067953 Danio rerio (zebra fish) XP_001913560 Entamoeba histolytica (anaerobic protozoan) XP_649340 Entamoeba histolytica (anaerobic protozoan) XP_655933 Entamoeba histolytica (anaerobic protozoan) XP_657581 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000011305 Gymnopilus aculeatus (mushroom) ENSGALP00000011717 Gallus gallus (chicken) GL50803_17054 Giardia lamblia (flagellated protozoan) 185645 Hypsipyla robusta (cedar shoot borer) ENSP00000339027 Homo sapiens (human) ISCW007303-PA Ixodes scapularis (deer tick) KLLA0B05918g Kluyveromyces lactis (yeast) 237709 Lottia gigantea (owl limpet) LmjF27.1380 Leishmania major (virus) LmjF27.1390 Leishmania major (virus) 18498 Monocosta brevicollis (choanoflagellate) ENSMODP00000018997 Monodelphis domestica (gray opossum) ENSMMUP00000012008 Macaca mulatta (rhesus monkey) ENSMUSP00000083705 Mus musculus (house mouse) 237425 Nematostella vectensis (starlet anemone) XP_001607606.1 Nasonia vitripennis (wasp) ENSOANP00000010417 Ornithorynchus anatinus (platypus) ENSORLP00000011508 Oryzias latipes (japanese killifish) LOC_Os08g03640.1 Oryza sativa (asian rice) LOC_Os11g04070.1 Oryza sativa (asian rice) LOC_Os12g03880.1 Oryza sativa (asian rice) 23034 Ostreococcus tauri (green alga) PF11_0313 Plasmodium falciparum (protozoal parasite) PHUM003529-PA Pediculus humanus (human body louse) PP09266 Pristionchus pacificus (nematode) 180102 Physcomitrella patens (moss) ENSPPYP00000005724 Pongo pygmaeus (orangutan) 71544 Phytophthora ramorum (sudden oak death pathogen) 109515 Phytophthora sojae (root rot pathogen) 822404 Populus trichocarpa (black cottonwood) ENSPTRP00000009378 Pan troglodytes (chimpanzee) PVX_092120 Plasmodium vivax (protozoal parasite) ENSRNOP00000001518 Rattus norvegicus (norway rat) 5058361 Sorghum bicolor (sorghum) YLR340W Saccharomyces cerevisiae (budding yeast) Smp_009690.1 Schistosoma mansoni (trematode parasite) SPCC18.14c Schizosaccharomyces pombe (fission yeast) 63360 Trichoplax adhaerens (metazoa) TA21355 Theileria annulata (apicomplexan parasite) XP_975936.1 Tribolium castaneum (red flour beetle) Tc00.1047053508355.250 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508355.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000013936 Tetraodon nigroviridis (green spotted pufferfish) TP01_0294 Theileria parva (parasitic protozoan) 25812 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040545 Takifugu rubripes (pufferfish Takifugu) 91.m00115 Tetrahymena thermophila (ciliate protozoa) 82012.m00128 Trichomonas vaginalis (parasitic flagellated protozoan) 85714.m00051 Trichomonas vaginalis (parasitic flagellated protozoan) 86633.m00157 Trichomonas vaginalis (parasitic flagellated protozoan) 92204.m00046 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000041250 Xenopus tropicalis (frog) YALI0B14146g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40451 modMine - Data generated by the modENCODE project. • FBgn0000100 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16486 PB13254 NV11446 LH21470 ISCW007303 FBgn0068063 FBgn0222440 FBgn0200805 FBgn0186691 FBgn0177299 JGI_V11_307348 FBgn0080384 FBgn0136532 FBgn0122143 FBgn0108479 FBgn0087986 CPIJ009501 BGIBMGA003309 ACYPI000079 GB12338 AGAP003592 AAEL010821 PHUM168440 GLEAN_16306
Synonyms & Secondary IDs ( 23 )
Reported As
Symbol Synonym	AP3 (Kurapati et al., 2000, Kelley, 1994.11.21, Yu and Wolfner, 1998, Kurapati et al., 2004) Ap3   Ape (Parsch et al., 1998, ) CG7490 (Gandhi et al., 2007, Marygold et al., 2007, Monzo et al., 2010, Ni et al., 2008, Cammarato et al., 2011) l(3)0154 (Frolov and Birchler, 1998) l(3)01544   LP0 (Carpenter et al., 2009) P0 (Frolov et al., 2000) p0 (Satterfield and Pallanck, 2006) P35 (Yu et al., 2002) PO (Birchler et al., 2001, Yacoub et al., 1996, Deutsch et al., 1995) RLA0 (Mushegian et al., 1998) RpLP0 (Beller et al., 2006, Gresens and Cook, 2006.12.5, Guo et al., 2008, Nie et al., 2009, Marygold et al., 2007, Monzo et al., 2010) RPL P0 (Farny et al., 2009) Rplp0 (Bandyopadhyay et al., 2006) RpP0 (Cherry et al., 2005, Dubnau et al., 2003, BDGP Project Members, 1994-1999, Stuart et al., 2007, Kurapati et al., 2004) RpPO (Gong et al., 2004)
Name Synonym	60S ribosomal protein P0 (Satterfield and Pallanck, 2006) ACIDIC RIBOSOMAL PROTEIN LP0 (Alonso and Santaren, 2006) Apurinic endonuclease 3   Ribosomal protein LP0 (Cammarato et al., 2011) Ribosomal protein P0   ribosomal protein P0 (Farny et al., 2008)
Secondary FlyBase IDs
	FBgn0010752
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Monzo et al., 2010, Dev. Biol. 340(2): 408--418 Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. [FBrf0210519] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...