FB2025_02 , released April 17, 2025
Gene: Dmel\RpLP0
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General Information
Symbol
Dmel\RpLP0
Species
D. melanogaster
Name
Ribosomal protein LP0
Annotation Symbol
CG7490
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000100
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (UniProt, P19889)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

RpP0, AP3, PO, Ape, LP0

Key Links
Genomic Location
Cytogenetic map
79B2-79B2
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:22075867..22077487
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from direct assay
(Yacoub et al., 1996)
enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity
inferred from direct assay
(Yacoub et al., 1996)
enables magnesium ion binding
inferred from direct assay
(Yacoub et al., 1996)
enables structural constituent of ribosome
inferred from direct assay
(Anger et al., 2013)
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables large ribosomal subunit rRNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000474664
(GO Reference Genome Project, 2011-)
enables structural constituent of ribosome
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000474664
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in base-excision repair
inferred from direct assay
(Yacoub et al., 1996)
involved_in nucleic acid metabolic process
inferred from direct assay
(Yacoub et al., 1996)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cytoplasmic translation
inferred by curator from GO:0022626
(Anger et al., 2013, Alonso and Santaren, 2006)
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000474664
(GO Reference Genome Project, 2011-)
involved_in ribosome biogenesis
inferred from electronic annotation with InterPro:IPR030670
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
located_in cytosol
inferred from direct assay
(Yacoub et al., 1996)
located_in nuclear matrix
inferred from direct assay
(Yacoub et al., 1996)
located_in nucleoplasm
inferred from direct assay
(Yacoub et al., 1996)
located_in ribosome
inferred from direct assay
(Yacoub et al., 1996)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of cytosolic large ribosomal subunit
traceable author statement
(Marygold et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000474664
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the universal ribosomal protein uL10 family. (P19889)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -
Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).
CLASS II APURINIC OR APYRIMIDINIC ENDONUCLEASES -
Class II apurinic or apyrimidinic endonucleases catalyze the hydrolysis of DNA backbone immediately 5_ of an apurinic/apyrimidinic residue by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-OH ends. Class II AP endonuclease play a crucial role in the base excision repair pathway. (Adapted from PMID:19401441).
Protein Function (UniProtKB)
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
(UniProt, P19889)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Ape: Apurinic endonuclease
Encodes an apurinic-apyrimidinic DNA endonuclease, AP3. Biochemical studies by Spiering and Deutsch (1986, J. Biol. Chem. 261: 3222-28).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\RpLP0 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P19889)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RpLP0-RA
FBtr0078481
NM_079487
1211
317
RpLP0-RB
FBtr0334113
NM_001275273
1328
317
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
RpLP0-PA
FBpp0078134
34.2
317
6.95
P19889
NP_524211
AAF51807
RpLP0-PB
FBpp0306232
34.2
317
6.95
P19889
NP_001262202
AGB94895
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

317 aa isoforms: RpLP0-PA, RpLP0-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

317 (aa); 34 (kD)

(Grabowski et al., 1991)
Comments

Contains CKI and CKII phosphorylation sites.

(Grabowski et al., 1991)
External Data
Subunit Structure (UniProtKB)

P0 forms a pentameric complex by interaction with dimers of P1 and P2.

(UniProt, P19889)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpLP0 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.52

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosolic ribosome
inferred from high throughput direct assay
(Alonso and Santaren, 2006)
inferred from direct assay
(Anger et al., 2013)
located_in cytosol
inferred from direct assay
(Yacoub et al., 1996)
located_in nuclear matrix
inferred from direct assay
(Yacoub et al., 1996)
located_in nucleoplasm
inferred from direct assay
(Yacoub et al., 1996)
located_in ribosome
inferred from direct assay
(Yacoub et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpLP0 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RpLP0
Transgenic constructs containing regulatory region of RpLP0
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\RPLP0
13 of 14
Yes
Yes
2  
Hsap\RPLP0P6
9 of 14
No
Yes
Hsap\MRTO4
2 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Rplp0
14 of 14
Yes
Yes
Rnor\Rplp0l1
8 of 14
No
Yes
Rnor\Mrto4
2 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Rplp0
13 of 14
Yes
Yes
Mmus\Mrto4
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\rplp0
7 of 13
Yes
Yes
Xtro\LOC101730580
1 of 13
No
Yes
Danio rerio (Zebrafish) (2)
Drer\rplp0
14 of 14
Yes
Yes
Drer\mrto4
2 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\rla-0
14 of 14
Yes
Yes
Cele\F10E7.5
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP003592
11 of 12
Yes
Yes
Agam\AgaP_AGAP007644
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AT2G40010
13 of 13
Yes
Yes
Atha\AT3G09200
13 of 13
Yes
Yes
Atha\AT3G11250
13 of 13
Yes
Yes
Atha\AT1G25260
2 of 13
No
No
Atha\AT3G12370
1 of 13
No
Yes
Atha\EMB3136
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\RPP0
13 of 13
Yes
Yes
Scer\MRT4
2 of 13
No
No
Scer\MRPL11
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\rpp0
12 of 12
Yes
Yes
Spom\mrt4
2 of 12
No
No
Spom\mrpl11
1 of 12
No
Yes
Escherichia coli (enterobacterium) (1)
Ecol\rplJ
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:RpLP0. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
RpLP0-like
3 of 13
RpLP1
1 of 13
RpLP2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RPLP0; ribosomal protein lateral stalk subunit P0
    13 of 14
    180510
         
        RPLP0P6; ribosomal protein lateral stalk subunit P0 pseudogene 6
        9 of 14
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            RpLP0 - CCT3
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - CG3008
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Chc
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Fim
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Glt
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Gp210
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Idh3a
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Nacα
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - PCID2
            cosedimentation, anti tag western blot
            (Farny et al., 2008)
            RpLP0 - Past1
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Pi3K68D
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - Rack1
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL10
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL10Ab
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL13A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL14
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL18A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL19
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL22
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL23A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL28
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL30
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL31
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL32
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL34a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL35
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL35A
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL36
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL36A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL37-1
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL37A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL38
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL39
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL40
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL41
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL5
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL6
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL7A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpL9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpLP1
            two hybrid, cosedimentation, Identification by mass spectrometry, electron microscopy
            (Hu et al., 2017.6.13, Anger et al., 2013)
            RpLP0 - RpLP2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS10a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS10b
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - RpS11
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS12
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS13
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS14a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS14b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS15
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS15Aa
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS16
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS17
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS18
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS19a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS20
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS21
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS23
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS24
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS25
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS26
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS27
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS27A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS28b
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS29
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS3
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS30
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS3A
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS4
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS5a
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS6
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS7
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS8
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - RpS9
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - TER94
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - boca
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - cPges
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - eEF2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - scf
            experimental knowledge based
            (Guruharsha et al., 2011)
            RpLP0 - sta
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RpLP0 - vig2
            cosedimentation, Identification by mass spectrometry, electron microscopy
            (Anger et al., 2013)
            RNA-protein
            Physical Interaction
            Assay
            References
            RpLP0 - 18SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - 28SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - 2SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - 5.8SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            RpLP0 - 5SrRNA
            cosedimentation, electron microscopy
            (Anger et al., 2013)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            fs(1)Ya
            suppressible
            RpLP0
            (Yu et al., 2002)
            w
            suppressible
            RpLP0
            (Frolov and Birchler, 1998)
            w
            enhanceable
            RpLP0
            (Frolov and Birchler, 1998)
            External Data
            Subunit Structure (UniProtKB)
            P0 forms a pentameric complex by interaction with dimers of P1 and P2.
            (UniProt, P19889 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-47
            Cytogenetic map
            79B2-79B2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            79B2-79B2
            Limits computationally determined from genome sequence between P{lacW}l(3)j1B10j1B10 and P{lacW}l(3)j2C4j2C4
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            79D1-79D2
            (determined by in situ hybridisation)
            (Spradling et al., 1999, BDGP Project Members, 1994-1999)
            79C-79D
            (determined by in situ hybridisation)
            (Kelley et al., 1989)
            Experimentally Determined Recombination Data
            Location

            3-47

            (FlyBase, 2016)

            3-44.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (10)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (742)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Not a Minute gene.

                (Marygold et al., 2007)

                Deletions removing RpLP0 but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

                (Marygold et al., 2007)

                Molecularly-defined mutations in RpLP0 do not result in Minute phenotypes.

                (Marygold et al., 2007)

                The RpLP0 containing 20S cytoplasmic complex may retain hyperphosphorylated ovarian fs(1)Ya in the cytoplasm.

                (Yu et al., 2002)

                RpLP0 is a general modifier of PEV, as well as a modifier of gene expression from the w locus.

                (Frolov and Birchler, 1998)

                RpLP0 acts on abasic DNA, a lesion known to block DNA replication and case mutations in E.coli. RpLP0 also contains vigorous DNase activity for both single- and double-stranded DNA. RpLP0 can be found in the nucleus tightly associated with the nuclear matrix.

                (Yacoub et al., 1996)

                Isolated from a cDNA expression library using antiserum directed against human enzyme known to cross react with the Drosophila enzyme (FBrf0044682).

                Encodes an apurinic-apyrimidinic DNA endonuclease, AP3.

                Relationship to Other Genes
                Source for database merge of

                Source for merge of: RpP0 l(3)01544

                (Frolov and Birchler, 1998)
                Additional comments
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (24)
                Reported As
                Symbol Synonym
                AP3
                (Kurapati et al., 2004, Kurapati et al., 2000, Yu and Wolfner, 1998, Kelley, 1994.11.21)
                Ap3
                Ape
                (Parsch et al., 1998)
                CG7490
                (Kolkhof et al., 2017, Rosa-Ferreira et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Jaspers et al., 2012, Muha et al., 2012, Cammarato et al., 2011, Monzo et al., 2010, Müller et al., 2010, Blagden et al., 2009, Ni et al., 2008, Gandhi et al., 2007, Marygold et al., 2007)
                L10
                (Anger et al., 2013)
                LP0
                (Wang et al., 2014, Carpenter et al., 2009)
                P0
                (Frolov et al., 2000)
                P35
                (Yu et al., 2002)
                PO
                (Birchler et al., 2001, Yacoub et al., 1996, Deutsch et al., 1995)
                RLA0
                (Mushegian et al., 1998)
                RPL P0
                (Farny et al., 2009)
                RpLP0
                (Lee et al., 2024, Meyer et al., 2024, Zheng et al., 2023, Ding et al., 2022, Hopes et al., 2022, Loganathan et al., 2022, Baumgartner et al., 2021, Lindsey et al., 2021, Malik et al., 2021, Polymenis, 2020, Hall et al., 2019, Hu et al., 2017.6.13, Zolotarev et al., 2017, Clandinin and Owens, 2016-, Dent et al., 2015, Ashwal-Fluss et al., 2014, Demontis et al., 2014, Handler et al., 2013, Kwon et al., 2013, Lee et al., 2013, Schertel et al., 2013, Muha et al., 2012, Ambegaokar and Jackson, 2011, Friedman et al., 2011, Monzo et al., 2010, Müller et al., 2010, Nie et al., 2009, Guo et al., 2008, Kaplow et al., 2007, Marygold et al., 2007, Beller et al., 2006, Gresens and Cook, 2006.12.5)
                RpP0
                (Stuart et al., 2007, Cherry et al., 2005, Kurapati et al., 2004, Dubnau et al., 2003, BDGP Project Members, 1994-1999)
                RpPO
                (Gong et al., 2004)
                Rplp0
                (Bandyopadhyay et al., 2006)
                l(3)0154
                (Frolov and Birchler, 1998)
                l(3)01544
                p0
                (Satterfield and Pallanck, 2006)
                Name Synonyms
                60S ribosomal protein P0
                (Satterfield and Pallanck, 2006)
                ACIDIC RIBOSOMAL PROTEIN LP0
                (Alonso and Santaren, 2006)
                Apurinic endonuclease 3
                Ribosomal protein LP0
                (Jaspers et al., 2012, Cammarato et al., 2011, Kaplow et al., 2007)
                Ribosomal protein P0
                ribosomal protein P0
                (Farny et al., 2008)
                Secondary FlyBase IDs
                • FBgn0010752
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 54 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (119)