FB2025_01 , released February 20, 2025
Gene: Dmel\Aprt
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General Information
Symbol
Dmel\Aprt
Species
D. melanogaster
Name
Adenine phosphoribosyltransferase
Annotation Symbol
CG18315
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000109
Gene Model Status
Current
Stock Availability
6 publicly available
Enzyme Name (EC)
adenine phosphoribosyltransferase (2.4.2.7)
Gene Summary
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (UniProt, P12426)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
62B9-62B9
Sequence location
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1883795..1885019
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables adenine binding
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
enables adenine phosphoribosyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR005764
(InterPro Project Members, 2004-)
enables AMP binding
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in adenine salvage
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR005764
(InterPro Project Members, 2004-)
involved_in AMP salvage
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(GO Reference Genome Project, 2011-)
located_in cytoplasm
inferred from electronic annotation with InterPro:IPR005764
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the purine/pyrimidine phosphoribosyltransferase family. (P12426)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
adenine phosphoribosyltransferase activity
AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine (2.4.2.7)
RHEA 16609:
Summaries
Gene Group (FlyBase)
UNCLASSIFIED PENTOSYLTRANSFERASES -
This group comprises pentosyltransferases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
(UniProt, P12426)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Aprt: Adenine phosphoribosyltransferase
Is the structural gene for adenine phosphoribosyl-transferase [APRT, AMP: pyrophosphate phosphoribosyl-transferase (EC 2.4.2.7)], a homodimer with 23,000 dalton subunits. It is a purine salvage enzyme which catalyzes the synthesis of AMP from 5-phosphoribosyl-1-pyrophosphate. Flies homozygous for a null allele Aprt1 survive on 15 times the concentration of purine that wild type tolerates and show about 2% wild-type enzyme activity; Aprt1/+ exhibit about half wild-type activity. Aprt2 has 9% normal enzyme activity. The dosage response suggests that the mutant affects the structural gene for APRT.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Aprt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P12426)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Aprt-RA
FBtr0089420
NM_057289
797
182
Aprt-RC
FBtr0346440
NM_001299979
894
182
Aprt-RD
FBtr0346441
NM_001299980
924
182
Additional Transcript Data and Comments
Reported size (kB)

1 (northern blot)

(Johnson et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Aprt-PA
FBpp0088438
19.7
182
5.37
P12426
NP_476637
AAF47589
Aprt-PC
FBpp0312098
19.7
182
5.37
P12426
NP_001286908
AHN57933
Aprt-PD
FBpp0312099
19.7
182
5.37
P12426
NP_001286909
AHN57934
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

182 aa isoforms: Aprt-PA, Aprt-PC, Aprt-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

183 (aa); 20 (kD predicted)

(Johnson et al., 1987)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P12426)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aprt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.54

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Aprt in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Aprt
Transgenic constructs containing regulatory region of Aprt
Aberrations (Deficiencies and Duplications) ( 155 )
Inferred from experimentation ( 155 )
Gene disrupted in
Df(3L)Aprt-1
(Wang et al., 1994)
Df(3L)Aprt-3
(Wang et al., 1994)
Df(3L)Aprt-9
(Wang et al., 1994)
Df(3L)Aprt-10
(Wang et al., 1994)
Df(3L)Aprt-12
(Wang et al., 1994)
Df(3L)Aprt-13
(Wang et al., 1994)
Df(3L)Aprt-14
(Wang et al., 1994)
Df(3L)Aprt-15
(Wang et al., 1994)
Df(3L)Aprt-16
(Wang et al., 1994)
Df(3L)Aprt-18
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-19
(Wang et al., 1994)
Df(3L)Aprt-21
(Shimojima et al., 2003, Wang et al., 1994)
Df(3L)Aprt-24
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-26
(Wang et al., 1994)
Df(3L)Aprt-27
(Wang et al., 1994)
Df(3L)Aprt-29
(Wang et al., 1994)
Df(3L)Aprt-31
(Wang et al., 1994)
Df(3L)Aprt-32
(Wang et al., 1994)
Df(3L)Aprt-36
(Wang et al., 1994)
Df(3L)Aprt-42
(Wang et al., 1994)
Df(3L)Aprt-46
(Wang et al., 1994)
Df(3L)Aprt-47
(Wang et al., 1994)
Df(3L)Aprt-48
(Wang et al., 1994)
Df(3L)Aprt-53
(Wang et al., 1994)
Df(3L)Aprt-54
(Wang et al., 1994)
Df(3L)Aprt-56
(Wang et al., 1994)
Df(3L)Aprt-57
(Wang et al., 1994)
Df(3L)Aprt-61
(Wang et al., 1994)
Df(3L)Aprt-65
(Wang et al., 1994)
Df(3L)Aprt-66
(Wang et al., 1994)
Df(3L)Aprt-71
(Wang et al., 1994)
Df(3L)Aprt-72
(Wang et al., 1994)
Df(3L)Aprt-73
(Wang et al., 1994)
Df(3L)Aprt-74
(Wang et al., 1994)
Df(3L)Aprt-77
(Wang et al., 1994)
Df(3L)Aprt-79
(Wang et al., 1994)
Df(3L)Aprt-84
(Wang et al., 1994)
Df(3L)Aprt-87
(Wang et al., 1994)
Df(3L)Aprt-88
(Wang et al., 1994)
Df(3L)Aprt-89
(Wang et al., 1994)
Df(3L)Aprt-90
(Wang et al., 1994)
Df(3L)Aprt-91
(Wang et al., 1994)
Df(3L)Aprt-92
(Wang et al., 1994)
Df(3L)Aprt-93
(Wang et al., 1994)
Df(3L)Aprt-94
(Wang et al., 1994)
Df(3L)Aprt-95
(Wang et al., 1994)
Df(3L)Aprt-96
(Wang et al., 1994)
Df(3L)Aprt-97
(Wang et al., 1994)
Df(3L)Aprt-98
(Wang et al., 1994)
Df(3L)Aprt-99
(Wang et al., 1994)
Df(3L)Aprt-100
(Wang et al., 1994)
Df(3L)Aprt-101
(Wang et al., 1994)
Df(3L)Aprt-102
(Wang et al., 1994)
Df(3L)Aprt-103
(Wang et al., 1994)
Df(3L)Aprt-104
(Wang et al., 1994)
Df(3L)Aprt-105
(Wang et al., 1994)
Df(3L)Aprt-106
(Wang et al., 1994)
Df(3L)Aprt-107
(Wang et al., 1994)
Df(3L)Aprt-108
(Wang et al., 1994)
Df(3L)Aprt-109
(Wang et al., 1994)
Df(3L)Aprt-110
(Wang et al., 1994)
Df(3L)Aprt-111
(Wang et al., 1994)
Df(3L)Aprt-112
(Wang et al., 1994)
Df(3L)Aprt-113
(Wang et al., 1994)
Df(3L)Aprt-114
(Wang et al., 1994)
Df(3L)Aprt-115
(Wang et al., 1994)
Df(3L)Aprt-116
(Wang et al., 1994)
Df(3L)Aprt-117
(Wang et al., 1994)
Df(3L)Aprt-118
(Wang et al., 1994)
Df(3L)Aprt-119
(Wang et al., 1994)
Df(3L)Aprt-120
(Wang et al., 1994)
Df(3L)Aprt-121
(Wang et al., 1994)
Df(3L)Aprt-122
(Wang et al., 1994)
Df(3L)Aprt-123
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-124
(Wang et al., 1994)
Df(3L)Aprt-125
(Wang et al., 1994)
Df(3L)Aprt-126
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-127
(Wang et al., 1994)
Df(3L)Aprt-128
(Wang et al., 1994)
Df(3L)Aprt-129
(Wang et al., 1994)
Df(3L)Aprt-130
(Wang et al., 1994)
Df(3L)Aprt-131
(Wang et al., 1994)
Df(3L)Aprt-132
(Wang et al., 1994)
Df(3L)Aprt-133
(Wang et al., 1994)
Df(3L)Aprt-134
(Wang et al., 1994)
Df(3L)Aprt-135
(Wang et al., 1994)
Df(3L)Aprt-136
(Wang et al., 1994)
Df(3L)Aprt-137
(Wang et al., 1994)
Df(3L)Aprt-138
(Wang et al., 1994)
Df(3L)Aprt-139
(Wang et al., 1994)
Df(3L)Aprt-140
(Wang et al., 1994)
Df(3L)Aprt-141
(Wang et al., 1994)
Df(3L)Aprt-142
(Wang et al., 1994)
Df(3L)Aprt-143
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-144
(Wang et al., 1994)
Df(3L)Aprt-145
(Wang et al., 1994)
Df(3L)Aprt-146
(Wang et al., 1994)
Df(3L)Aprt-147
(Wang et al., 1994)
Df(3L)Aprt-148
(Wang et al., 1994)
Df(3L)Aprt-149
(Wang et al., 1994)
Df(3L)Aprt-150
(Wang et al., 1994)
Df(3L)Aprt-151
(Wang et al., 1994)
Df(3L)Aprt-152
(Wang et al., 1994)
Df(3L)Aprt-153
(Wang et al., 1994)
Df(3L)Aprt-154
(Wang et al., 1994)
Df(3L)Aprt-156
(Wang et al., 1994)
Df(3L)Aprt-157
(Wang et al., 1994)
Df(3L)Aprt-158
(Wang et al., 1994)
Df(3L)Aprt-159
(Wang et al., 1994)
Df(3L)Aprt-160
(Wang et al., 1994)
Df(3L)Aprt-161
(Wang et al., 1994)
Df(3L)Aprt-162
(Wang et al., 1994)
Df(3L)Aprt-163
(Wang et al., 1994)
Df(3L)Aprt-164
(Wang et al., 1994)
Df(3L)Aprt-165
(Wang et al., 1994)
Df(3L)Aprt-166
(Wang et al., 1994)
Df(3L)Aprt-167
(Wang et al., 1994)
Df(3L)Aprt-168
(Wang et al., 1994)
Df(3L)Aprt-169
(Wang et al., 1994)
Df(3L)Aprt-170
(Wang et al., 1994)
Df(3L)Aprt-171
(Wang et al., 1994)
Df(3L)Aprt-172
(Wang et al., 1994)
Df(3L)Aprt-173
(Wang et al., 1994)
Df(3L)Aprt-174
(Wang et al., 1994)
Df(3L)Aprt-175
(Wang et al., 1994)
Df(3L)Aprt-176
(Wang et al., 1994)
Df(3L)Aprt-177
(Wang et al., 1994)
Df(3L)Aprt-178
(Wang et al., 1994)
Df(3L)Aprt-180
(Wang et al., 1994)
Df(3L)Aprt-181
(Wang et al., 1994)
Df(3L)Aprt-182
(Wang et al., 1994)
Df(3L)Aprt-183
(Wang et al., 1994)
Df(3L)Aprt-184
(Wang et al., 1994)
Df(3L)Aprt-186
(Wang et al., 1994)
Df(3L)Aprt-187
(Wang et al., 1994)
Df(3L)Aprt-188
(Wang et al., 1994)
Df(3L)Aprt-189
(Wang et al., 1994)
Df(3L)Aprt-190
(Wang et al., 1994)
Df(3L)Aprt-191
(Wang et al., 1994)
Df(3L)Aprt-192
(Wang et al., 1994)
Df(3L)Aprt-193
(Wang et al., 1994)
Df(3L)Aprt-194
(Wang et al., 1994)
Df(3L)Aprt-195
(Wang et al., 1994)
Df(3L)Aprt-196
(Wang et al., 1994)
Df(3L)Aprt-198
(Wang et al., 1994)
Df(3L)Aprt-199
(Wang et al., 1994)
Df(3L)Aprt-201
(Wang et al., 1994)
Df(3L)R-E
(Johnson and Friedman, 1983)
Df(3L)R-G2
(Sliter et al., 1989)
Df(3L)R-G7
(Sliter et al., 1989)
Ts(2Rt;3Rt)Aprt-185
(Wang et al., 1994)
Gene duplicated in
Dp(3;Y)H141
(Johnson and Friedman, 1983)
Ts(Y;3Rt)R132
(Johnson and Friedman, 1983)
Gene not duplicated in
Dp(3;Y)P3
(Johnson and Friedman, 1983)
Ts(Y;3Lt)P3
(Johnson and Friedman, 1983)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal sleep | adult stage
bang sensitive
bang sensitive, with Scer\GAL4da.PU
bang sensitive (with Df(3L)BSC365)
bang sensitive (with Df(3L)ED4284)
chemical resistant
decreased rate of adult locomotory behavior
decreased rate of adult locomotory behavior, with Scer\GAL4238Y
decreased rate of adult locomotory behavior, with Scer\GAL4da.PU
decreased rate of adult locomotory behavior, with Scer\GAL4Eaat1.PR
decreased rate of adult locomotory behavior, with Scer\GAL4elav-C155
decreased rate of adult locomotory behavior, with Scer\GAL4GMR58E02
decreased rate of adult locomotory behavior, with Scer\GAL4GMR58E02, Scer\GAL4ple.PF
decreased rate of adult locomotory behavior, with Scer\GAL4GMR76F05
decreased rate of adult locomotory behavior, with Scer\GAL4NP6510
decreased rate of adult locomotory behavior, with Scer\GAL4repo.PU
decreased rate of adult locomotory behavior, with Scer\GAL4VT030559
decreased rate of adult locomotory behavior (with Df(3L)BSC365)
decreased rate of adult locomotory behavior (with Df(3L)ED4284)
decreased sleep | adult stage
decreased sleep | adult stage, with Scer\GAL4elav-C155
decreased sleep | adult stage, with Scer\GAL4elav-C155, Scer\GAL4repo.PU
electrophoretic variant
electrophoretic variant | fast
electrophoretic variant | slow
increased rate of movement | adult stage
long lived | dominant
short lived
some die during pupal stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\APRT
14 of 14
Yes
Yes
Hsap\UMPS
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Aprt
14 of 14
Yes
Yes
Rnor\Umps
1 of 14
No
No
Mus musculus (laboratory mouse) (2)
Mmus\Aprt
13 of 14
Yes
Yes
Mmus\Umps
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\aprt
7 of 13
Yes
Yes
Xtro\piezo1
5 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\aprt
14 of 14
Yes
Yes
Drer\umps
1 of 14
No
No
Drer\zgc:174895
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\T19B4.3
14 of 14
Yes
Yes
Cele\umps-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP005723
12 of 12
Yes
Yes
Agam\AgaP_AGAP004175
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\APT1
12 of 13
Yes
Yes
Atha\APT2
11 of 13
No
Yes
Atha\APT3
11 of 13
No
Yes
Atha\APT4
11 of 13
No
Yes
Atha\APT5
11 of 13
No
Yes
Atha\AT3G54470
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\APT1
12 of 13
Yes
Yes
Scer\APT2
9 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\apt1
12 of 12
Yes
Yes
Escherichia coli (enterobacterium) (1)
Ecol\apt
9 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Aprt. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
Aprt5
model of  Lesch-Nyhan syndrome
CEA
(Petitgas et al., 2024)
AprtKK108921
model of  Lesch-Nyhan syndrome
CEA
(Petitgas et al., 2024)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
APRT; adenine phosphoribosyltransferase
14 of 14
102600
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Aprt - CG13220
experimental knowledge based
(Guruharsha et al., 2011)
Aprt - Gmd
experimental knowledge based
(Guruharsha et al., 2011)
Aprt - Rab7
experimental knowledge based
(Guruharsha et al., 2011)
Aprt - ScsβG
experimental knowledge based
(Guruharsha et al., 2011)
Aprt - TrpRS
experimental knowledge based
(Guruharsha et al., 2011)
Aprt - Tspo
experimental knowledge based
(Guruharsha et al., 2011)
Summary of Genetic Interactions
esyN Network Diagram
Other Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Homodimer.
(UniProt, P12426 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-1.0
Cytogenetic map
62B9-62B9
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
62B9-62B9
Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
62B9-62B9
(determined by in situ hybridisation)
(Johnson et al., 1987)
62B7-62B12
(Johnson and Friedman, 1983)
Experimentally Determined Recombination Data
Location

3-1.0

(FlyBase, 2016)

3-3.0

(Comeron et al., 2012)

3-3.03

(Johnson and Friedman, 1983)

3-1.49

Left of (cM)
Right of (cM)
(Johnson and Friedman, 1983, Johnson and Friedman, 1981)
Notes
Stocks and Reagents
Stocks (6)
Genomic Clones (20)
cDNA Clones (5)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
    Other Stable Cell Lines
     
      Other Comments

      DNA sequence conservation between Dpse\Aprt and Aprt has identified a nuclear matrix attachment site. A palindrome with direct repeats of non-conserved DNA sequences may act as a promoter for Aprt.

      (Johnson, 1993)

      Comparison of CpG distribution in the coding region of 121 genes from six species supports the mCpG mutational hotspot explanation of CpG suppression in methylated species at position II-III and III-I.

      (Schorderet and Gartler, 1992)

      In Aprt and Dpse\Aprt the use of alternate 5' splice sites to process an intron in pre-mRNA leads to simultaneous production of RNAs encoding nonfunctional proteins in addition to functional Aprt or Dpse\Aprt, respectively.

      (Johnson and Henikoff, 1989)

      The structural gene for adenine phosphoribosyltransferase.

      Mutant flies are resistant to the toxic effects of dietary purine.

      Relationship to Other Genes
      Source for database merge of

      Source for merge of: Aprt CG18315

      (Misra, 2000.4.6)

      Source for merge of: Aprt BcDNA:LP07986

      (FlyBase, 1996-)
      Additional comments

      Source for merge of Aprt BcDNA:LP07986 was a shared cDNA ( date:030728 ).

      (FlyBase, 1996-)
      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (7)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 55 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      References (55)