FB2021_02, released April 13, 2021

Gene: Dmel\Aprt

Open Close
General Information
Symbol
Dmel\Aprt
Species
D. melanogaster
Name
Adenine phosphoribosyltransferase
Annotation Symbol
CG18315
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000109
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (UniProt, P12426)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
62B9-62B9
Sequence location
3L:1,883,795..1,885,019 [-]
Recombination map
3-1.0
RefSeq locus
NT_037436 REGION:1883795..1885019
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables adenine binding
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
enables adenine phosphoribosyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
enables AMP binding
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in adenine salvage
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in AMP salvage
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in nucleoside metabolic process
inferred from electronic annotation with InterPro:IPR000836
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002088255
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the purine/pyrimidine phosphoribosyltransferase family. (P12426)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
OTHER PENTOSYLTRANSFERASES -
The Other pentosyltransferases is a collection of transferases that do not fit into any of the other major transferases transferring pentosyl groups.
Protein Function (UniProtKB)
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
(UniProt, P12426)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Aprt: Adenine phosphoribosyltransferase
Is the structural gene for adenine phosphoribosyl-transferase [APRT, AMP: pyrophosphate phosphoribosyl-transferase (EC 2.4.2.7)], a homodimer with 23,000 dalton subunits. It is a purine salvage enzyme which catalyzes the synthesis of AMP from 5-phosphoribosyl-1-pyrophosphate. Flies homozygous for a null allele Aprt1 survive on 15 times the concentration of purine that wild type tolerates and show about 2% wild-type enzyme activity; Aprt1/+ exhibit about half wild-type activity. Aprt2 has 9% normal enzyme activity. The dosage response suggests that the mutant affects the structural gene for APRT.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Aprt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Aprt-RA
FBtr0089420
NM_057289
797
182
Aprt-RC
FBtr0346440
NM_001299979
894
182
Aprt-RD
FBtr0346441
NM_001299980
924
182
Additional Transcript Data and Comments
Reported size (kB)

1 (northern blot)

(Johnson et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Aprt-PA
FBpp0088438
19.7
182
5.37
NP_476637
AAF47589
Aprt-PC
FBpp0312098
19.7
182
5.37
NP_001286908
AHN57933
Aprt-PD
FBpp0312099
19.7
182
5.37
NP_001286909
AHN57934
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

182 aa isoforms: Aprt-PA, Aprt-PC, Aprt-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

183 (aa); 20 (kD predicted)

(Johnson et al., 1987)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P12426)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aprt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Aprt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Aprt
Transgenic constructs containing regulatory region of Aprt
Aberrations (Deficiencies and Duplications) ( 155 )
Inferred from experimentation ( 155 )
Gene disrupted in
Df(3L)Aprt-1
(Wang et al., 1994)
Df(3L)Aprt-3
(Wang et al., 1994)
Df(3L)Aprt-9
(Wang et al., 1994)
Df(3L)Aprt-10
(Wang et al., 1994)
Df(3L)Aprt-12
(Wang et al., 1994)
Df(3L)Aprt-13
(Wang et al., 1994)
Df(3L)Aprt-14
(Wang et al., 1994)
Df(3L)Aprt-15
(Wang et al., 1994)
Df(3L)Aprt-16
(Wang et al., 1994)
Df(3L)Aprt-18
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-19
(Wang et al., 1994)
Df(3L)Aprt-21
(Shimojima et al., 2003, Wang et al., 1994)
Df(3L)Aprt-24
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-26
(Wang et al., 1994)
Df(3L)Aprt-27
(Wang et al., 1994)
Df(3L)Aprt-29
(Wang et al., 1994)
Df(3L)Aprt-31
(Wang et al., 1994)
Df(3L)Aprt-32
(Wang et al., 1994)
Df(3L)Aprt-36
(Wang et al., 1994)
Df(3L)Aprt-42
(Wang et al., 1994)
Df(3L)Aprt-46
(Wang et al., 1994)
Df(3L)Aprt-47
(Wang et al., 1994)
Df(3L)Aprt-48
(Wang et al., 1994)
Df(3L)Aprt-53
(Wang et al., 1994)
Df(3L)Aprt-54
(Wang et al., 1994)
Df(3L)Aprt-56
(Wang et al., 1994)
Df(3L)Aprt-57
(Wang et al., 1994)
Df(3L)Aprt-61
(Wang et al., 1994)
Df(3L)Aprt-65
(Wang et al., 1994)
Df(3L)Aprt-66
(Wang et al., 1994)
Df(3L)Aprt-71
(Wang et al., 1994)
Df(3L)Aprt-72
(Wang et al., 1994)
Df(3L)Aprt-73
(Wang et al., 1994)
Df(3L)Aprt-74
(Wang et al., 1994)
Df(3L)Aprt-77
(Wang et al., 1994)
Df(3L)Aprt-79
(Wang et al., 1994)
Df(3L)Aprt-84
(Wang et al., 1994)
Df(3L)Aprt-87
(Wang et al., 1994)
Df(3L)Aprt-88
(Wang et al., 1994)
Df(3L)Aprt-89
(Wang et al., 1994)
Df(3L)Aprt-90
(Wang et al., 1994)
Df(3L)Aprt-91
(Wang et al., 1994)
Df(3L)Aprt-92
(Wang et al., 1994)
Df(3L)Aprt-93
(Wang et al., 1994)
Df(3L)Aprt-94
(Wang et al., 1994)
Df(3L)Aprt-95
(Wang et al., 1994)
Df(3L)Aprt-96
(Wang et al., 1994)
Df(3L)Aprt-97
(Wang et al., 1994)
Df(3L)Aprt-98
(Wang et al., 1994)
Df(3L)Aprt-99
(Wang et al., 1994)
Df(3L)Aprt-100
(Wang et al., 1994)
Df(3L)Aprt-101
(Wang et al., 1994)
Df(3L)Aprt-102
(Wang et al., 1994)
Df(3L)Aprt-103
(Wang et al., 1994)
Df(3L)Aprt-104
(Wang et al., 1994)
Df(3L)Aprt-105
(Wang et al., 1994)
Df(3L)Aprt-106
(Wang et al., 1994)
Df(3L)Aprt-107
(Wang et al., 1994)
Df(3L)Aprt-108
(Wang et al., 1994)
Df(3L)Aprt-109
(Wang et al., 1994)
Df(3L)Aprt-110
(Wang et al., 1994)
Df(3L)Aprt-111
(Wang et al., 1994)
Df(3L)Aprt-112
(Wang et al., 1994)
Df(3L)Aprt-113
(Wang et al., 1994)
Df(3L)Aprt-114
(Wang et al., 1994)
Df(3L)Aprt-115
(Wang et al., 1994)
Df(3L)Aprt-116
(Wang et al., 1994)
Df(3L)Aprt-117
(Wang et al., 1994)
Df(3L)Aprt-118
(Wang et al., 1994)
Df(3L)Aprt-119
(Wang et al., 1994)
Df(3L)Aprt-120
(Wang et al., 1994)
Df(3L)Aprt-121
(Wang et al., 1994)
Df(3L)Aprt-122
(Wang et al., 1994)
Df(3L)Aprt-123
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-124
(Wang et al., 1994)
Df(3L)Aprt-125
(Wang et al., 1994)
Df(3L)Aprt-126
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-127
(Wang et al., 1994)
Df(3L)Aprt-128
(Wang et al., 1994)
Df(3L)Aprt-129
(Wang et al., 1994)
Df(3L)Aprt-130
(Wang et al., 1994)
Df(3L)Aprt-131
(Wang et al., 1994)
Df(3L)Aprt-132
(Wang et al., 1994)
Df(3L)Aprt-133
(Wang et al., 1994)
Df(3L)Aprt-134
(Wang et al., 1994)
Df(3L)Aprt-135
(Wang et al., 1994)
Df(3L)Aprt-136
(Wang et al., 1994)
Df(3L)Aprt-137
(Wang et al., 1994)
Df(3L)Aprt-138
(Wang et al., 1994)
Df(3L)Aprt-139
(Wang et al., 1994)
Df(3L)Aprt-140
(Wang et al., 1994)
Df(3L)Aprt-141
(Wang et al., 1994)
Df(3L)Aprt-142
(Wang et al., 1994)
Df(3L)Aprt-143
(Machado and Andrew, 2000, Wang et al., 1994)
Df(3L)Aprt-144
(Wang et al., 1994)
Df(3L)Aprt-145
(Wang et al., 1994)
Df(3L)Aprt-146
(Wang et al., 1994)
Df(3L)Aprt-147
(Wang et al., 1994)
Df(3L)Aprt-148
(Wang et al., 1994)
Df(3L)Aprt-149
(Wang et al., 1994)
Df(3L)Aprt-150
(Wang et al., 1994)
Df(3L)Aprt-151
(Wang et al., 1994)
Df(3L)Aprt-152
(Wang et al., 1994)
Df(3L)Aprt-153
(Wang et al., 1994)
Df(3L)Aprt-154
(Wang et al., 1994)
Df(3L)Aprt-156
(Wang et al., 1994)
Df(3L)Aprt-157
(Wang et al., 1994)
Df(3L)Aprt-158
(Wang et al., 1994)
Df(3L)Aprt-159
(Wang et al., 1994)
Df(3L)Aprt-160
(Wang et al., 1994)
Df(3L)Aprt-161
(Wang et al., 1994)
Df(3L)Aprt-162
(Wang et al., 1994)
Df(3L)Aprt-163
(Wang et al., 1994)
Df(3L)Aprt-164
(Wang et al., 1994)
Df(3L)Aprt-165
(Wang et al., 1994)
Df(3L)Aprt-166
(Wang et al., 1994)
Df(3L)Aprt-167
(Wang et al., 1994)
Df(3L)Aprt-168
(Wang et al., 1994)
Df(3L)Aprt-169
(Wang et al., 1994)
Df(3L)Aprt-170
(Wang et al., 1994)
Df(3L)Aprt-171
(Wang et al., 1994)
Df(3L)Aprt-172
(Wang et al., 1994)
Df(3L)Aprt-173
(Wang et al., 1994)
Df(3L)Aprt-174
(Wang et al., 1994)
Df(3L)Aprt-175
(Wang et al., 1994)
Df(3L)Aprt-176
(Wang et al., 1994)
Df(3L)Aprt-177
(Wang et al., 1994)
Df(3L)Aprt-178
(Wang et al., 1994)
Df(3L)Aprt-180
(Wang et al., 1994)
Df(3L)Aprt-181
(Wang et al., 1994)
Df(3L)Aprt-182
(Wang et al., 1994)
Df(3L)Aprt-183
(Wang et al., 1994)
Df(3L)Aprt-184
(Wang et al., 1994)
Df(3L)Aprt-186
(Wang et al., 1994)
Df(3L)Aprt-187
(Wang et al., 1994)
Df(3L)Aprt-188
(Wang et al., 1994)
Df(3L)Aprt-189
(Wang et al., 1994)
Df(3L)Aprt-190
(Wang et al., 1994)
Df(3L)Aprt-191
(Wang et al., 1994)
Df(3L)Aprt-192
(Wang et al., 1994)
Df(3L)Aprt-193
(Wang et al., 1994)
Df(3L)Aprt-194
(Wang et al., 1994)
Df(3L)Aprt-195
(Wang et al., 1994)
Df(3L)Aprt-196
(Wang et al., 1994)
Df(3L)Aprt-198
(Wang et al., 1994)
Df(3L)Aprt-199
(Wang et al., 1994)
Df(3L)Aprt-201
(Wang et al., 1994)
Df(3L)R-E
(Johnson and Friedman, 1983)
Df(3L)R-G2
(Sliter et al., 1989)
Df(3L)R-G7
(Sliter et al., 1989)
Ts(2Rt;3Rt)Aprt-185
(Wang et al., 1994)
Gene duplicated in
Dp(3;Y)H141
(Johnson and Friedman, 1983)
Ts(Y;3Rt)R132
(Johnson and Friedman, 1983)
Gene not duplicated in
Dp(3;Y)P3
(Johnson and Friedman, 1983)
Ts(Y;3Lt)P3
(Johnson and Friedman, 1983)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\APRT
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aprt
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Aprt
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\aprt
13 of 12
Yes
Yes
Xtro\LOC100145149
2 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\aprt
10 of 15
Yes
Yes
Drer\zgc:174895
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\T19B4.3
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\APT1
8 of 9
Yes
Yes
Atha\APT2
7 of 9
No
Yes
Atha\APT3
7 of 9
No
Yes
Atha\APT4
7 of 9
No
Yes
Atha\APT5
7 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\APT1
12 of 15
Yes
Yes
Scer\APT2
8 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\apt1
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HEI )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004436
Drosophila simulans
Dsim\GD13427
Drosophila sechellia
Dsec\GM14157
Drosophila erecta
Dere\GG14548
Drosophila yakuba
Dyak\GE20903
Drosophila ananassae
Dana\GF24950
Drosophila persimilis
Dper\GL24816
Drosophila willistoni
Dwil\GK19711
Drosophila virilis
Dvir\GJ13276
Drosophila mojavensis
Dmoj\GI12006
Drosophila grimshawi
Dgri\GH15295
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150C47 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017059
Glossina morsitans
Tsetse fly
Gmor\GMOY001635
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07122
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005976
Anopheles darlingi
American malaria mosquito
Adar\ADAC002031
Anopheles gambiae
Malaria mosquito
Agam\AGAP005723
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002169
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EVR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013902
Danaus plexippus
Monarch butterfly
Dple\DPOGS213322-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007378
Apis florea
Little honeybee
Aflo\3101740548
Apis mellifera
Western honey bee
Amel\Aprt
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP11169
Bombus terrestris
Buff-tailed bumblebee
Bter\15208936
Linepithema humile
Argentine ant
Lhum\LH24715
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002b46
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005228
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11491
Tribolium castaneum
Red flour beetle
Tcas\TC009597
Pediculus humanus
Human body louse
Phum\PHUM039550
Rhodnius prolixus
Kissing bug
Rpro\RPRC001397
Cimex lectularius
Bed bug
Clec\CLEC010403
Cimex lectularius
Bed bug
Clec\CLEC007109
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003436
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003109
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02898
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0EV5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006273
Ixodes scapularis
Black-legged tick
Isca\ISCW010922
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81000.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur15g03460
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311079
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0XZC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aprt
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018906
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027272
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    APRT; adenine phosphoribosyltransferase
    14 of 15
    102600
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Aprt - CG13220
    experimental knowledge based
    (Guruharsha et al., 2011)
    Aprt - Gmd
    experimental knowledge based
    (Guruharsha et al., 2011)
    Aprt - Rab7
    experimental knowledge based
    (Guruharsha et al., 2011)
    Aprt - ScsβG
    experimental knowledge based
    (Guruharsha et al., 2011)
    Aprt - TrpRS
    experimental knowledge based
    (Guruharsha et al., 2011)
    Aprt - Tspo
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Homodimer.
    (UniProt, P12426 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-1.0
    Cytogenetic map
    62B9-62B9
    Sequence location
    3L:1,883,795..1,885,019 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    62B9-62B9
    Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    62B9-62B9
    (determined by in situ hybridisation)
    (Johnson et al., 1987)
    62B7-62B12
    (Johnson and Friedman, 1983)
    Experimentally Determined Recombination Data
    Location

    3-1.0

    (FlyBase, 2016)

    3-3.0

    (Comeron et al., 2012)

    3-3.03

    (Johnson and Friedman, 1983)

    3-1.49

    Left of (cM)
    Right of (cM)
    (Johnson and Friedman, 1983, Johnson and Friedman, 1981)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (20)
    cDNA Clones (5)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: Aprt CG18315

      (Misra, 2000.4.6)

      Source for merge of: Aprt BcDNA:LP07986

      (FlyBase, 1996-)
      Additional comments

      Source for merge of Aprt BcDNA:LP07986 was a shared cDNA ( date:030728 ).

      (FlyBase, 1996-)
      Other Comments

      DNA sequence conservation between Dpse\Aprt and Aprt has identified a nuclear matrix attachment site. A palindrome with direct repeats of non-conserved DNA sequences may act as a promoter for Aprt.

      (Johnson, 1993)

      Comparison of CpG distribution in the coding region of 121 genes from six species supports the mCpG mutational hotspot explanation of CpG suppression in methylated species at position II-III and III-I.

      (Schorderet and Gartler, 1992)

      In Aprt and Dpse\Aprt the use of alternate 5' splice sites to process an intron in pre-mRNA leads to simultaneous production of RNAs encoding nonfunctional proteins in addition to functional Aprt or Dpse\Aprt, respectively.

      (Johnson and Henikoff, 1989)

      The structural gene for adenine phosphoribosyltransferase.

      Mutant flies are resistant to the toxic effects of dietary purine.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 44 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Aprt
      (Transgenic RNAi Project members, 2017-, Bischof and FlyORF project members, 2014.6.20, Stenesen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Reumer et al., 2009)
      BcDNA:LP07986
      CG18315
      (Keleman et al., 2009.8.5, Reumer et al., 2009, Goldman and Arbeitman, 2007)
      aprt
      Name Synonyms
      Adenine Phosphoribosyltransferase
      (Stenesen et al., 2013)
      Adenine phosphoribosyltransferase
      (Reumer et al., 2009)
      CG18315
      (Goldman and Arbeitman, 2007)
      Secondary FlyBase IDs
      • FBgn0035288
      • FBgn0063099
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (50)