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Gene Dmel\Argk

General Information
Symbol	Dmel\Argk	Species	D. melanogaster
Name	Arginine kinase	Annotation symbol	CG32031
Feature type	protein_coding_gene	FlyBase ID	FBgn0000116
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	AK, CG4929, ARK
Genomic Location
Chromosome (arm)	3L	Recombination map	3-25.2
Cytogenetic map	66F3-66F4	Sequence location	3L:9,041,962..9,059,127 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Arginine kinase is referred to in FlyBase by the symbol Dmel\Argk (CG32031, FBgn0000116). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: arginine kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: phosphorylation. 19 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; trichogen cell. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: ATP:guanido phosphotransferase; ATP:guanido phosphotransferase active site; ATP:guanido phosphotransferase, N-terminal; ATP:guanido phosphotransferase, catalytic domain; Glutamine synthetase/guanido kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of low expression. Peak expression observed at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult fat body, virgin spermatheca. Comments on Affy2 ProbeSet: ProbeSet 1625633_a_at completely aligns to an exonic region common to each of the 6 FlyBase-annotated transcript isoforms of Argk. Gene sequence location is 3L:9041962..9059127.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Argk: Arginine kinase Structural gene for arginine kinase [ARGK (EC 2.7.3.3)] based on gene dosage studies. Cellular and mitochondrial forms behave as if both are products of the gene. (Munneke and Collier, 1985, Genetics 110: s85). In 108-hour third-instar larvae, activity is high in body-wall and digestive-tract musculature; lower in brain, imaginal discs, and salivary glands; present in head, thorax, and abdomen of adults, being highest in indirect flight muscle of thorax. Activity levels increase during development reaching a peak at the pupal stage; then an abrupt decrease during the pupal stage is followed by a second increase beginning around the time of eclosion and climbing to high adult levels (James and Collier).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA08959 BKN51373 BKN27683 BKN50041 HFA10460 HFA09668
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66F3-66F4   Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66F-66F     (Hecht, 1995.5.11) 66F-66F   (determined by in situ hybridisation)   (Hecht et al., 1994) 66B-66F   Segmental aneuploids (unspecified) produced flies duplicated for region 66B-66F that exhibit elevated Argk activity.   (Fu and Collier, 1981) 66B-66B   Segmental aneuploids (unspecified) identify 66B as the dosage sensitive region for Argk.   (Munneke and Collier, 1985)
Experimentally Determined Recombination Data
Location	3- (Choudhary et al., 1992) 3-25.2 (Munneke and Collier, 1985, ) 1- (FlyBase, 1992-)
Left of (cM)
Right of (cM)	elav (FlyBase, 1992-)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Argk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Argk-RA FBtr0076543  NM_168311   2433   562 Argk-RB FBtr0076544  NM_168312   2196   432 Argk-RC FBtr0076546  NM_168313   2117   396 Argk-RD FBtr0076545  NM_079264   1535   356 Argk-RE FBtr0112791  NM_001104085   1872   375 Argk-RF FBtr0112792  NM_001104086   1621   356
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Argk-PA   FBpp0076270   61.3   562   7.58     NP_729446   AAF50325 Argk-PB   FBpp0076271   47.9   432   5.90     NP_729447   AAN11982 Argk-PC   FBpp0076273   43.8   396   6.08     NP_729448   AAF50326 Argk-PD   FBpp0076272   39.9   356   6.43     NP_523988   AAN11983 Argk-PE   FBpp0111703   42.2   375   6.26     NP_001097555   ABW08501 Argk-PF   FBpp0111704   39.9   356   6.43     NP_001097556   ABW08502
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutamine synthetase/guanido kinase, catalytic domain (IPR014746) ATP:guanido phosphotransferase (IPR000749) ATP:guanido phosphotransferase, N-terminal (IPR022413) ATP:guanido phosphotransferase, catalytic domain (IPR022414) ATP:guanido phosphotransferase active site (IPR022415)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540871   AA694669   AA697726   AA698565   AA699071   AA801500   AA803415   AA950668   AA951093   AE014296 AAF50325   AE014296 AAF50326   AE014296 AAN11982   AE014296 AAN11983   AE014296 ABW08501   AE014296 ABW08502   AI063798   AI106841   AI106987   AI107314   AI107357   AI107630   AI108324   AI113742   AI134260   AI134638   AI134840   AI135401   AI293560   AI294603   AI295507   AI296235   AI387840   AI388496   AI388865   AI389832   AI402280   AI403288   AI403774   AI404396   AI405638   AI405903   AI456953   AI513350   AI514039   AI519149   AI531766   AI532471   AI534909   AK259023   AW940421   AY069099 AAL39244   BF493995   BF499094   BF499123   BF504447   BF505117   BF506181   BG632129   BG633180   BG633308   BG633525   BG636611   BI163075   BI163909   BI165865   BI166672   BI167418   BI168885   BI169160   BI171923   BI172768   BI173314   BI214975   BI216005   BI216020   BI231924   BI234088   BI238942   BI352756   BI354889   BI355847   BI356661   BI372638   BI373319   BI375048   BI481905   BI482031   BI482814   BI483239   BI483369   BI485986   BI563387   BI563617   BI563777   BI564008   BI564054   BI564437   BI564798   BI564890   BI564949   BI565090   BI565479   BI565793   BI566260   BI566799   BI567002   BI567054   BI567069   BI567254   BI567465   BI567568   BI567573   BI567622   BI567901   BI568086   BI568121   BI568263   BI568299   BI568402   BI568416   BI568688   BI570117   BI570220   BI570771   BI571641   BI572208   BI572315   BI572589   BI572801   BI573121   BI574197   BI574371   BI574447   BI574590   BI574639   BI574670   BI574695   BI574702   BI574904   BI575138   BI575216   BI575232   BI575692   BI575813   BI576212   BI576238   BI576248   BI576654   BI576866   BI576914   BI577432   BI577784   BI581170   BI581454   BI581506   BI581597   BI582428   BI582607   BI582812   BI583016   BI583330   BI583680   BI583830   BI583948   BI584289   BI584445   BI584454   BI584583   BI584666   BI584789   BI584790   BI584812   BI584821   BI584865   BI584988   BI585563   BI585581   BI585657   BI586010   BI586194   BI586249   BI586467   BI586517   BI586903   BI587440   BI587953   BI588233   BI588378   BI588645   BI588677   BI588754   BI588758   BI588775   BI588842   BI588854   BI589049   BI589114   BI589240   BI589365   BI589782   BI589872   BI589990   BI590243   BI590357   BI590593   BI590758   BI590774   BI590775   BI590974   BI591289   BI591463   BI591804   BI592036   BI592103   BI592274   BI592543   BI592811   BI592929   BI593387   BI604300   BI604432   BI604587   BI604592   BI604754   BI605011   BI605076   BI605119   BI605510   BI605588   BI605752   BI605791   BI605800   BI606037   BI606130   BI606224   BI606645   BI606837   BI607095   BI608165   BI608189   BI608202   BI608208   BI608312   BI608372   BI609048   BI609076   BI609136   BI609342   BI609694   BI609707   BI609810   BI610279   BI610846   BI611055   BI611240   BI611362   BI611469   BI611511   BI611560   BI611653   BI611658   BI612388   BI613078   BI613266   BI613388   BI613425   BI613598   BI613617   BI613816   BI613951   BI614090   BI614200   BI614420   BI614896   BI614919   BI615028   BI615282   BI615303   BI615465   BI615528   BI615654   BI615872   BI615912   BI616273   BI616644   BI616646   BI616692   BI618224   BI618384   BI618440   BI618471   BI618621   BI618885   BI619016   BI619332   BI619499   BI619602   BI619634   BI619767   BI619785   BI619897   BI620158   BI620241   BI620929   BI621027   BI621262   BI621363   BI621728   BI621745   BI621761   BI621826   BI621957   BI622023   BI622051   BI622177   BI622196   BI622483   BI622558   BI622668   BI622888   BI623063   BI623226   BI623978   BI624025   BI624337   BI624360   BI624362   BI625146   BI625359   BI625734   BI625759   BI626151   BI626568   BI627603   BI627618   BI628216   BI628677   BI629031   BI629108   BI629218   BI629230   BI629314   BI629398   BI629405   BI629877   BI629884   BI630322   BI630457   BI630505   BI630531   BI630784   BI630831   BI631179   BI631211   BI631323   BI631422   BI631536   BI631538   BI631582   BI631708   BI632882   BI633775   BI634244   BI634269   BI634305   BI634365   BI634440   BI634795   BI634893   BI637803   BI638770   BI638897   BI639873   BI640761   BP541622   BP549687   BP550975   BP559894   BT030260   BX012886   BX013815   BX014766   BX017349   BX019436   BX020231   BX020455   BX023142   BX025226   BX028652   BX032744   BX033139   BX033413   BX034868   BX036226   BX039691   BX039884   BX040867   BX044605   BX050775   BX053381   BX055571   BX055661   BX060013   BX060050   BX060802   BX063634   BX064112   BX071796   CK659597   CL528268   CO178918   CO178984   CO186642   CO263121   CO264292   CO264515   CO273755   CO273765   CO274962   CO275755   CO276068   CO276167   CO280990   CO288041   CO297574   CO298376   CO298731   CO299861   CO299881   CO300613   CO305588   CO307114   CO310242   CO312150   CO319795   CO320956   CO321748   CO326238   CO328918   CO332749   CO336539   CR938335   CZ470400   CZ475247   CZ475248   CZ475957   CZ478742   CZ487889   DN154165   DQ311338   DQ440227   EC053732   EC054338   EC059760   EC062867   EC063327   EC067836   EC071448   EC071462   EC072018   EC076046   EC084573   EC086305   EC206317   EC209409   EC209790   EC210702   EC211087   EC213408   EC214791   EC216070   EC219578   EC219579   EC220849   EC221307   EC222818   EC227487   EC230277   EC234190   EC237910   EC243362   EC243372   EC247099   EC251890   EC263273   EL872639   EL872883   EL873902   EL879645   EL881691   EL884625   EL884626   EL886035   EL886081   EL886185   ES688617   ES689870   ES689981   ES690200   ES690202   ES690205   ES690213   ES690214   ES690215   ES690230   ES690234   ES690246   ES690248   ES690269   ES690285   ES693559   ES694561   EV578005   EV579994   EV583496   EV587758   EV587961   EV589293   EV591908   EV593498   EV593775   EV594075   EV595251   EV596257   EV598902   EV599553   EV600329   GH839749   GH941459   GH942098   GH942162   GH943254   GH943309   GH943514   GH945646   GH945767   GH946074   GH946156   GH946189   GH946510   GH946843   GH946925   GH948395   GH949052   GH949257   GH949401   GH949720   GH949726   GH950156   GH950554   GH951478   GH951564   GH951582   GH951609   GH951704   GH952172   GH952187   GH952509   GH952747   GH952952   GH953379   GH953804   GH954777   GH955065   GH955193   GH955339   GH957399   GH957806   GH958648   GH958753   GH958824   GH959066   GH959679   GH960185   GH960526   GH961026   GH961174   GH961539   GH962106   GH962353   GH962439   GH963473   GH964048   GH964539   GH964834   GH965123   GH965160   GH965223   GH965552   GH965907   GH967512   GH967690   GH968178   GH968188   GH968361   GH968637   GH969773   GH970371   GH970464   GH970723   GH971556   GH971590   GH971671   GH972938   GH973804   GH974141   GH974257   GH975016   GH975122   GH976309   GH976531   GH976955   GH977515   GH977613   GH978100   GH978624   GH978702   GH979521   GH979651   GH979738   GH980190   GH981696   GH982701   U26939 AAA68172   U26940 AAA68173
UniProtKB/Swiss-Prot	P48610
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference prepupal stage   imaginal disc   (James and Collier, 1990) pharate adult stage P15   organism   (James and Collier, 1990) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Argk enzyme activity is present throughout development but there are sharp, transient peaks during the prepupal period and at eclosion. The greatest increase in activity is seen in imaginal discs in the prepupal period. This peak is not seen at the restrictive temperature in the ts-ecdysoneless mutant ecd1 but reappears after larvae are shifted back to a nonrestrictive temperature or fed 20-hydroxyecdysone. (James and Collier, 1990)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000116    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000116 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of low expression. Peak expression observed at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000116 expression level Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr    30283 embryo 12-14hr    19433 embryo 14-16hr    22521 embryo 16-18hr    12992 embryo 18-20hr    10881 embryo 20-22hr    18303 embryo 22-24hr    15915 larva L1    60551 larva L2    68479 larva L3 12hr old    126994 larva L3 puffstage 1-2    114346 larva L3 puffstage 3-6    63142 larva L3 puffstage 7-9    20203 white prepupae new    10548 white prepupae 12hr    18605 white prepupae 24hr    27593 pupae 2d postWPP    47558 pupae 3d postWPP    52375 pupae 4d postWPP    24192 adult male 01day    55929 adult male 05day    67926 adult male 30day    37880 adult female 01day    38790 adult female 05day    16096 adult female 30day    13592 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8263) embryo 02-04hr  (432) embryo 04-06hr  (348) embryo 06-08hr  (3621) embryo 08-10hr  (9100) embryo 10-12hr  (30283) embryo 12-14hr  (19433) embryo 14-16hr  (22521) embryo 16-18hr  (12992) embryo 18-20hr  (10881) embryo 20-22hr  (18303) embryo 22-24hr  (15915) larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  (20203) white prepupae new  (10548) white prepupae 12hr  (18605) white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  (16096) adult female 30day  (13592) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8263) embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr  (3621) embryo 08-10hr  (9100) embryo 10-12hr  (30283) embryo 12-14hr  (19433) embryo 14-16hr  (22521) embryo 16-18hr  (12992) embryo 18-20hr  (10881) embryo 20-22hr  (18303) embryo 22-24hr  (15915) larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  (20203) white prepupae new  (10548) white prepupae 12hr  (18605) white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  (16096) adult female 30day  (13592) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr  (30283) embryo 12-14hr  (19433) embryo 14-16hr  (22521) embryo 16-18hr  (12992) embryo 18-20hr  (10881) embryo 20-22hr  (18303) embryo 22-24hr  (15915) larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  (20203) white prepupae new  10548 white prepupae 12hr  (18605) white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  (16096) adult female 30day  (13592) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr    30283 embryo 12-14hr    19433 embryo 14-16hr    22521 embryo 16-18hr    12992 embryo 18-20hr    10881 embryo 20-22hr    18303 embryo 22-24hr    15915 larva L1    60551 larva L2    68479 larva L3 12hr old    126994 larva L3 puffstage 1-2    114346 larva L3 puffstage 3-6    63142 larva L3 puffstage 7-9    20203 white prepupae new    10548 white prepupae 12hr    18605 white prepupae 24hr    27593 pupae 2d postWPP    47558 pupae 3d postWPP    52375 pupae 4d postWPP    24192 adult male 01day    55929 adult male 05day    67926 adult male 30day    37880 adult female 01day    38790 adult female 05day    16096 adult female 30day    13592 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000116 expression level Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr    30283 embryo 12-14hr    19433 embryo 14-16hr    22521 embryo 16-18hr    12992 embryo 18-20hr    10881 embryo 20-22hr    18303 embryo 22-24hr    15915 larva L1    60551 larva L2    68479 larva L3 12hr old    126994 larva L3 puffstage 1-2    114346 larva L3 puffstage 3-6    63142 larva L3 puffstage 7-9    20203 white prepupae new    10548 white prepupae 12hr    18605 white prepupae 24hr    27593 pupae 2d postWPP    47558 pupae 3d postWPP    52375 pupae 4d postWPP    24192 adult male 01day    55929 adult male 05day    67926 adult male 30day    37880 adult female 01day    38790 adult female 05day    16096 adult female 30day    13592 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8263) embryo 02-04hr  (432) embryo 04-06hr  (348) embryo 06-08hr  (3621) embryo 08-10hr  (9100) embryo 10-12hr  (30283) embryo 12-14hr  (19433) embryo 14-16hr  (22521) embryo 16-18hr  (12992) embryo 18-20hr  (10881) embryo 20-22hr  (18303) embryo 22-24hr  (15915) larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  (20203) white prepupae new  (10548) white prepupae 12hr  (18605) white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  (16096) adult female 30day  (13592) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8263) embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr  (3621) embryo 08-10hr  (9100) embryo 10-12hr  (30283) embryo 12-14hr  (19433) embryo 14-16hr  (22521) embryo 16-18hr  (12992) embryo 18-20hr  (10881) embryo 20-22hr  (18303) embryo 22-24hr  (15915) larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  (20203) white prepupae new  (10548) white prepupae 12hr  (18605) white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  (16096) adult female 30day  (13592) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr  (30283) embryo 12-14hr  19433 embryo 14-16hr  (22521) embryo 16-18hr  12992 embryo 18-20hr  10881 embryo 20-22hr  18303 embryo 22-24hr  15915 larva L1  (60551) larva L2  (68479) larva L3 12hr old  (126994) larva L3 puffstage 1-2  (114346) larva L3 puffstage 3-6  (63142) larva L3 puffstage 7-9  20203 white prepupae new  10548 white prepupae 12hr  18605 white prepupae 24hr  (27593) pupae 2d postWPP  (47558) pupae 3d postWPP  (52375) pupae 4d postWPP  (24192) adult male 01day  (55929) adult male 05day  (67926) adult male 30day  (37880) adult female 01day  (38790) adult female 05day  16096 adult female 30day  13592 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8263 embryo 02-04hr    432 embryo 04-06hr    348 embryo 06-08hr    3621 embryo 08-10hr    9100 embryo 10-12hr    30283 embryo 12-14hr    19433 embryo 14-16hr    22521 embryo 16-18hr    12992 embryo 18-20hr    10881 embryo 20-22hr    18303 embryo 22-24hr    15915 larva L1    60551 larva L2    68479 larva L3 12hr old    126994 larva L3 puffstage 1-2    114346 larva L3 puffstage 3-6    63142 larva L3 puffstage 7-9    20203 white prepupae new    10548 white prepupae 12hr    18605 white prepupae 24hr    27593 pupae 2d postWPP    47558 pupae 3d postWPP    52375 pupae 4d postWPP    24192 adult male 01day    55929 adult male 05day    67926 adult male 30day    37880 adult female 01day    38790 adult female 05day    16096 adult female 30day    13592 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000116    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000116 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult fat body, virgin spermatheca. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000116 expression level Tissue   Expression Level Larval Central Nervous System    2162.775 Larval Midgut    4081.6 Larval Hindgut    4477 Larval Malpighian Tubules    1335.9 Larval Fat Body    159.5 Larval Salivary Gland    1003.8 Larval Trachea    1095.775 Larval Carcass    4969.175 Adult Head    3401.1 Adult Eye    3384.875 Adult Brain    3224.1 Adult Thoracic-Abdominal Ganglion    3847.1 Adult Crop    4926 Adult Midgut    3572.7 Adult Hindgut    4430.3 Adult Malpighian Tubules    1589.2 Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart    3723.025 Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass    4501.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2162.775) Larval Midgut  (4081.6) Larval Hindgut  (4477) Larval Malpighian Tubules  (1335.9) Larval Fat Body    159.5 Larval Salivary Gland  (1003.8) Larval Trachea  (1095.775) Larval Carcass  (4969.175) Adult Head  (3401.1) Adult Eye  (3384.875) Adult Brain  (3224.1) Adult Thoracic-Abdominal Ganglion  (3847.1) Adult Crop  (4926) Adult Midgut  (3572.7) Adult Hindgut  (4430.3) Adult Malpighian Tubules  (1589.2) Adult Fat Body    211.4 Adult Salivary Gland  (924.8) Adult Heart  (3723.025) Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca  (602.5) Adult Ovary  (741.7) Adult Testis  (716.6) Adult Male Accessory Gland  (852.2) Adult Carcass  (4501.1) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2162.775) Larval Midgut  (4081.6) Larval Hindgut  (4477) Larval Malpighian Tubules  (1335.9) Larval Fat Body    159.5 Larval Salivary Gland  1003.8 Larval Trachea  (1095.775) Larval Carcass  (4969.175) Adult Head  (3401.1) Adult Eye  (3384.875) Adult Brain  (3224.1) Adult Thoracic-Abdominal Ganglion  (3847.1) Adult Crop  (4926) Adult Midgut  (3572.7) Adult Hindgut  (4430.3) Adult Malpighian Tubules  (1589.2) Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart  (3723.025) Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass  (4501.1) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2162.775 Larval Midgut    4081.6 Larval Hindgut    4477 Larval Malpighian Tubules    1335.9 Larval Fat Body    159.5 Larval Salivary Gland    1003.8 Larval Trachea    1095.775 Larval Carcass    4969.175 Adult Head    3401.1 Adult Eye    3384.875 Adult Brain    3224.1 Adult Thoracic-Abdominal Ganglion    3847.1 Adult Crop    4926 Adult Midgut    3572.7 Adult Hindgut    4430.3 Adult Malpighian Tubules    1589.2 Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart    3723.025 Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass    4501.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000116 expression level Tissue   Expression Level Larval Central Nervous System    2162.775 Larval Midgut    4081.6 Larval Hindgut    4477 Larval Malpighian Tubules    1335.9 Larval Fat Body    159.5 Larval Salivary Gland    1003.8 Larval Trachea    1095.775 Larval Carcass    4969.175 Adult Head    3401.1 Adult Eye    3384.875 Adult Brain    3224.1 Adult Thoracic-Abdominal Ganglion    3847.1 Adult Crop    4926 Adult Midgut    3572.7 Adult Hindgut    4430.3 Adult Malpighian Tubules    1589.2 Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart    3723.025 Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass    4501.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2162.775) Larval Midgut  (4081.6) Larval Hindgut  (4477) Larval Malpighian Tubules  (1335.9) Larval Fat Body    159.5 Larval Salivary Gland  (1003.8) Larval Trachea  (1095.775) Larval Carcass  (4969.175) Adult Head  (3401.1) Adult Eye  (3384.875) Adult Brain  (3224.1) Adult Thoracic-Abdominal Ganglion  (3847.1) Adult Crop  (4926) Adult Midgut  (3572.7) Adult Hindgut  (4430.3) Adult Malpighian Tubules  (1589.2) Adult Fat Body    211.4 Adult Salivary Gland  (924.8) Adult Heart  (3723.025) Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca  602.5 Adult Ovary  741.7 Adult Testis  716.6 Adult Male Accessory Gland  (852.2) Adult Carcass  (4501.1) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2162.775) Larval Midgut  (4081.6) Larval Hindgut  (4477) Larval Malpighian Tubules  1335.9 Larval Fat Body    159.5 Larval Salivary Gland  1003.8 Larval Trachea  1095.775 Larval Carcass  (4969.175) Adult Head  (3401.1) Adult Eye  (3384.875) Adult Brain  (3224.1) Adult Thoracic-Abdominal Ganglion  (3847.1) Adult Crop  (4926) Adult Midgut  (3572.7) Adult Hindgut  (4430.3) Adult Malpighian Tubules  1589.2 Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart  (3723.025) Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass  (4501.1) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2162.775 Larval Midgut    4081.6 Larval Hindgut    4477 Larval Malpighian Tubules    1335.9 Larval Fat Body    159.5 Larval Salivary Gland    1003.8 Larval Trachea    1095.775 Larval Carcass    4969.175 Adult Head    3401.1 Adult Eye    3384.875 Adult Brain    3224.1 Adult Thoracic-Abdominal Ganglion    3847.1 Adult Crop    4926 Adult Midgut    3572.7 Adult Hindgut    4430.3 Adult Malpighian Tubules    1589.2 Adult Fat Body    211.4 Adult Salivary Gland    924.8 Adult Heart    3723.025 Adult VirginFemale Spermatheca    440.7 Adult InseminatedFemale Spermatheca    602.5 Adult Ovary    741.7 Adult Testis    716.6 Adult Male Accessory Gland    852.2 Adult Carcass    4501.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3401.1   NA  Eye    3384.875   NA  Brain    3224.1   2162.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3847.1   NA  Crop    4926   4081.6  Midgut    3572.7   4477  Hindgut    4430.3   1335.9  Malpighian Tubules    1589.2   159.5  Fat Body    211.4   1003.8  Salivary Gland    924.8   NA  Heart    3723.025   1095.775  Trachea    NA   NA  VirginFemale Spermatheca    440.7   NA  InseminatedFemale Spermatheca    602.5   NA  Ovary    741.7   NA  Testis    716.6   NA  Male Accessory Gland    852.2   4969.175  Carcass    4501.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000116 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32031-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Argk Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ArgkCB03789 ArgkCB05492 lethal | recessive Argkl1 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ArgkGD10436 viable ArgkKG10020 ArgkPL00418 Sterility Allele fertile ArgkKG10020 ArgkPL00418 Other Phenotypes Allele electrophoretic variant ArgkA ArgkB visible, with Scer\GAL4pnr-MD237 ArgkGD10436 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 ArgkGD10436 trichogen cell, with Scer\GAL4pnr-MD237 ArgkGD10436
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of Argk Class Mutagen Stocks Known lesion Argkc05979 piggyBac transposase 1 -- Argkd06615 P-element activity 1 -- Argke00908 piggyBac transposase 1 -- Argkf01693 1 -- Argkf05255 piggyBac transposase 1 -- ArgkKG10020 P-element activity 1 -- ArgkPL00418 P-element activity 1 -- ArgkA natural population 0 -- ArgkB natural population 0 -- ArgkCB03789 P-element activity 0 Yes ArgkCB05492 P-element activity 0 Yes ArgkCPTI004299 piggyBac transposase 0 Yes Argkd07847 P-element activity 0 -- ArgkEP584MR2 Delta2-3 0 Yes Argkl1 ethyl methanesulfonate 0 Yes ArgkMB P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Argk Class Mutagen Stocks Known lesion ArgkGD10436 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ArgkGL00102 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ArgkJF02699 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6113 (Ryder, 2004.4.26)
Duplicated in	Dp(3;3)BK18 (Munneke and Collier, 1988) Dp(3;3)BK20 (Munneke and Collier, 1988) Dp(3;3)BK32 (Munneke and Collier, 1988)
Not disrupted in	Df(3L)29A6 (Munneke and Collier, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10436} NA P{TRiP.GL00102} NA P{TRiP.JF02699} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{PTT-GB}ArgkCB03789 NA P{PTT-GB}ArgkCB05492 NA P{PTT-un1}ArgkMB NA P{SUPor-P}ArgkKG10020 NA PBac{810.P.FSVS-2}ArgkCPTI004299 NA PBac{PB}Argkc05979 NA PBac{RB}Argke00908 NA PBac{WH}Argkf01693 NA PBac{WH}Argkf05255 NA insertion of mobile activating element P{XP}Argkd06615 NA P{XP}Argkd07847 NA insertion of enhancer trap binary system PBac{GAL4D,EYFP}ArgkPL00418 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
arginine kinase activity inferred from sequence or structural similarity with UniProtKB:P91798 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Biological Process
CV term Evidence References
phosphorylation inferred from sequence or structural similarity with UniProtKB:P91798 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Argk allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64445 DroID - A comprehensive database of gene and protein interactions. • FBgn0000116 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39041
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23510 Dere\GG15040 Dmoj\GI16555 Dper\GL15080 Dpse\GA16624 Dsec\GM24893 Dvir\GJ12807 Dwil\GK23865 Dyak\GE21263
Curated drosophilid orthologs	Dpse\GA16624   Dsim\Argk
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009185-PA Aedes aegypti (mosquito) AGAP005627-PA Anopheles gambiae (mosquito) NP_001011603.1 Apis mellifera (honey bee) 129321 Branchiostoma floridae (lancelet) BGIBMGA005812-PA Bombyx mori (silk worm) ENSBTAP00000004079 Bos taurus (bovine) CN02590 Caenorhabditis brenneri (small nematode) CBP29209 Caenorhabditis briggsae (nematode) CE37112 Caenorhabditis elegans (worm) ENSCAFP00000032827 Canis familiaris (dog) ENSCINP00000022369 Ciona intestinalis (sea squirt) JA13507 Caenorhabditis japonica (nematode) CPIJ007538 Culex pipens (mosquito) ENSCPOP00000016471 Cavia porcellus (guinea pig) RP20426 Caenorhabditis remanei (nematode) ENSCSAVP00000016889 Ciona savignyi (sedentary tunicate) 149896 Capitella spl (polychaete worm) 220693 Daphnia pulex (daphnia) ENSDARP00000037871 Danio rerio (zebra fish) ENSECAP00000019848 Equus caballus (horse) ENSGACP00000016500 Gymnopilus aculeatus (mushroom) ENSGALP00000018743 Gallus gallus (chicken) ENSP00000299198 Homo sapiens (human) 183253 Lottia gigantea (owl limpet) 21418 Monocosta brevicollis (choanoflagellate) ENSMODP00000016895 Monodelphis domestica (gray opossum) ENSMMUP00000024964 Macaca mulatta (rhesus monkey) ENSMUSP00000003643 Mus musculus (house mouse) 215593 Nematostella vectensis (starlet anemone) XP_001607122.1 Nasonia vitripennis (wasp) ENSOANP00000001217 Ornithorynchus anatinus (platypus) ENSOANP00000023266 Ornithorynchus anatinus (platypus) ENSORLP00000022417 Oryzias latipes (japanese killifish) PHUM005636-PA Pediculus humanus (human body louse) PP10805 Pristionchus pacificus (nematode) ENSPPYP00000011314 Pongo pygmaeus (orangutan) 71216 Phytophthora ramorum (sudden oak death pathogen) 108967 Phytophthora sojae (root rot pathogen) ENSPTRP00000011527 Pan troglodytes (chimpanzee) ENSRNOP00000022895 Rattus norvegicus (norway rat) XP_001176159.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001181395.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198416.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971800.2 Tribolium castaneum (red flour beetle) Tc00.1047053507241.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022170 Tetraodon nigroviridis (green spotted pufferfish) 263946 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004007 Takifugu rubripes (pufferfish Takifugu) 3700.m00194 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000041410 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12741 LH12999 ISCW021028 ISCW020252 FBgn0238532 FBgn0225827 FBgn0200042 FBgn0179755 JGI_V11_220693 FBgn0076639 FBgn0152684 FBgn0139303 FBgn0123373 FBgn0107294 FBgn0100504 CPIJ007538 BGIBMGA005812 GB10973 AGAP012924 AGAP005627 AAEL009185 PB23384 PHUM616180 GLEAN_13596 GLEAN_02600
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	16497 y1; P{SUPor-P}ArgkKG10020 ry506 35221 y1 sc* v1; P{TRiP.GL00102}attP2 31959 y1 v1; P{TRiP.JF02699}attP2/TM3, Sb1 19611 w*; PBac{GAL4D,EYFP}ArgkPL00418 P{FRT(whs)}2A P{neoFRT}82B
Harvard	- P{XP}Argkd06615 - PBac{PB}Argkc05979 - PBac{RB}Argke00908 - PBac{WH}Argkf01693 - PBac{WH}Argkf05255
VDRC	v34036 w1118; P{GD10436}v34036 v34037 w1118; P{GD10436}v34037/TM3
Genomic Clones ( 2 )
	BACR03E24 BACR10P09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 553 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11670
Other clones	IP18368
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02392 AT05810 AT07284 AT08584 AT13582 AT13618 GH03824 GH06264 GH10183 GH12406 GH13117 GH21704 GH23280 GH24028 GH26055 GH26529 GM10794 GM20613 GM28708 GM32579 HL03051 HL07409 LD20704 LD30595 LD37132 LD38596 LP06730 RE02382 RE03437 RE05848 RE07804 RE09771 RE13822 RE15440 RE16212 RE21148 RE22789 RE25106 RE59648 RE62766 RE64522 RE64673 RE65576 RE66107 RE66251 RE69351 RE71108 RH03529 RH04444 RH05243 RH07568 RH09725 RH10588 RH11417 RH12384 RH12717 RH13880 RH14527 RH15390 RH17560 RH17892 RH18035 RH18990 RH20486 RH20871 RH22676 RH22932 RH23356 RH24066 RH25170 RH26117 RH26419 RH27126 RH27453 RH29721 RH30032 RH31476 RH32761 RH33256 RH33582 RH37992 RH38042 RH38101 RH38409 RH42381 RH42789 RH42816 RH43058 RH43783 RH44419 RH45119 RH45352 RH45756 RH48824 RH49109 RH49234 RH49489 RH49823 RH50709 RH50873 RH51034 RH51230 RH51326 RH52190 RH52692 RH53126 RH53831 RH53865 RH54366 RH54576 RH54923 RH55132 RH56405 RH56562 RH57922 RH58053 RH58066 RH58158 RH58258 RH58810 RH58817 RH59563 RH60151 RH60704 RH60741 RH61133 RH61179 RH61339 RH62460 RH62553 RH63910 RH63912 RH65720 RH66764 RH68958 RH71660 SD01183 SD03026 SD04007 SD14357 SD19888 SD21142 SD21301 SD22570 SD23755 SD26777 SD27934
Other clones	11240 11698 11768 30485 30637 37234 40196 48574 50742 53233 59674 66058 66568 72911 98312 98922 146338 146855 176073 180239 214343.77 277143 557964 CK01.24A.F4 CK01.73C.D2 CK01.104C.A10 CK01.128A.C4 CK01.142A.H7 CK01.142D.C6 CK01.145C.D1 CK01.145D.D2 Dmel_dig_003503_0667_0595 Dmel_dig_006655_0616_1453 Dmel_dig_016190_0700_3277 Dmel_neb_007915_0652_0526 Dmel_neb_008905_0594_3104 Dmel_neb_008971_0627_0992 Dmel_neb_009222_0136_2673 Dmel_neb_010113_0845_2347 Dmel_neb_010358_0379_0838 Dmel_neb_013547_0882_1489 Dmel_neb_013879_0607_2451 Dmel_neb_014142_0161_2331 Dmel_neb_015432_0945_2583 Dmel_neb_015759_0674_2968 Dmel_neb_015792_0702_0788 EC054338 EK021754 EK057945 EK058116 EK067601 EK087535 EK112111 EK112124 EK116043 EK118532 EK119613 EK119845 EK138428 EK139444 EK155653 EK170118 EK172855 EK173710 EK176752 EK176831 EK178808 EK186313 EK192804 EK220850 EK227950 EK249023 EK253632 EK280819 EK289408 EK291650 EK304434 EN12731 EP03507 FGC003F06 FGM102H07 FGM210C05 FGM323E06 GH03778 GH04115 GH04166 GH05414 GH06078 GH07139 GH12157 GH18509 GH19433 GH19906 GH21108 GH22692 GH24079 GH25728 GH27087 GM01210 HL02655 HL04935 IP04528 IP04728 IP09577 IP11506 IP13980 IP15886 IP17331 IP17371 IP17469 LD31378 LP08017 LP09166 LP10083 LP17464 RE06868 RE10252 RE22811 RE29727 RE35317 RE42851 RE60578 RE71526 RH02371 RH02506 RH03269 RH03377 RH03835 RH03965 RH04235 RH04424 RH04445 RH04669 RH05034 RH05551 RH06784 RH06905 RH07801 RH08152 RH08441 RH08831 RH09637 RH09921 RH10257 RH10754 RH12343 RH12369 RH12390 RH12785 RH13776 RH13818 RH14112 RH14514 RH14644 RH16791 RH17151 RH17421 RH17692 RH17830 RH18030 RH18510 RH18913 RH19120 RH21227 RH21448 RH21918 RH22345 RH22531 RH23367 RH23483 RH23653 RH23665 RH23827 RH23921 RH24067 RH24094 RH24109 RH24162 RH24353 RH24756 RH25190 RH25281 RH25728 RH25944 RH25982 RH26048 RH26475 RH26515 RH26525 RH28119 RH28412 RH28885 RH29371 RH29573 RH29763 RH30076 RH30169 RH30173 RH30193 RH30281 RH30294 RH30722 RH30794 RH31613 RH31794 RH32132 RH32730 RH32773 RH33515 RH34018 RH34284 RH34488 RH34976 RH35461 RH35733 RH36546 RH36825 RH36885 RH36906 RH37152 RH37672 RH37865 RH38003 RH38158 RH38493 RH39032 RH39153 RH39210 RH39443 RH39502 RH39672 RH39716 RH39842 RH39859 RH40353 RH40842 RH42150 RH42537 RH42575 RH43222 RH43383 RH43521 RH44390 RH44544 RH44879 RH44908 RH45195 RH45812 RH46176 RH46683 RH46687 RH46741 RH49318 RH49974 RH50347 RH50545 RH50670 RH50893 RH52308 RH52575 RH53144 RH53162 RH53244 RH53758 RH54013 RH54032 RH54451 RH55327 RH56348 RH57183 RH57824 RH58266 RH59340 RH59505 RH59594 RH60083 RH60877 RH60990 RH61135 RH61712 RH62312 RH62761 RH63257 RH63617 RH63880 RH65136 RH66217 RH66243 RH67547 RH68974 RH69613 RH69779 RH70010 RH70015 RH70221 RH70523 RH70593 RH70648 RH71144 RH71390 RH71748 RH71765 RH72117 RH72329 RH72451 RH73253 RH73672 RH74088 RP003521593 RP004014135 RP004022161 RP004024797 RP004028711 RP004049870 RP004059586 RP004099540 RP004102240 RP004104288 RP004108955 RP004123997 RP004129973 RP004136144 RP004139385 RP004143632 RP004148460 RP004149265 RP004155036 RP004156661 RP004156807 RP004157462 RP004158009 RP004169475 RP004174726 RP004181108 RP004181620 RP004185712 RP004190176 RP004190819 RP004196410 RP004214346 RP004216982 RP004218097 RP004219630 RP004221940 RP004222931 RP004223695 RP004226148 RP004228120 RP004228901 RP004243597 RP004248217 RP004248588 RP004249568 RP004249933 RP004251553 RP004253456 RP004256540 RP004258247 RP004258836 RP004259416 RP004263968 RP004267851 RP004285878 RP004288788 RP004305617 RP004317013 RP004322725 RP004350178 RP004351637 RP004367088 RP004369386 RP004375411 RP004389350 RP004409124 RP004410388 RP004410631 RP004423486 RP004426449 RP004428299 RP004436097 RP004453301 RP004455640 RP004459177 RP004459337 RP004463972 RP004466775 RP004485891 RP004490570 RP004495025 RP004495283 RP004495427 RP004499138 RP004502772 RP004508605 RP004514045 RP004525430 RP004525932 RP004528285 RP004534953 RP004537776 RP004539398 RP004544297 RP004547985 RP004553425
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000116 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39041
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Argk CG4929 (FlyBase, 1996-) Source for merge of: CG5173 CG4929 (Artero, 2001.7.23)
Additional comments	Annotations CG4929, CG5173 merged as CG32031 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of Argk CG4929 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	Investigation of the Argk isoenzyme system in flight muscle. (Wyss et al., 1995) Developmentally regulated peak of arginine kinase activity in prepupae is under the influence of ecdysone. Altered doses of Eip75B and ecdysone inducible genes of the BRC alter the pattern of expression of Argk while altered dose of Eip74EF has no effect. (James and Collier, 1992) Immunological distances were measured by microcomplement fixation for 20 species of Drosophila Argk. The unit evolutionary period for Drosophila Argk is estimated to be 59 million years. The value predicted for vertebrate creatine kinase was 30 million years. The difference may be because a single gene encodes Drosophila Argk whereas three genes encode various forms of vertebrate creatine kinase. (Collier, 1990) Argk encodes two isozymes that have parallel gene-dosage responses, immunological similarities and cosegregation of electrophoretic mobility differences. (Munneke and Collier, 1988) Structural gene for arginine kinase (ARGK) based on gene dosage studies. Cellular and mitochondrial forms behave as if both are products of the gene. (FBrf0042737).   high in body-wall and digestive-tract musculature;
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079264 NM_168311 NM_168312 NM_168313 NM_001104085 NM_001104086 RefSeq (Proteins) • NP_523988 NP_729446 NP_729447 NP_729448 NP_001097555 NP_001097556 DDBJ / EMBL / GenBank • AA694669 AAA68172 AAA68173 AAF50325 AAF50326 AAL39244 AAN11982 AAN11983 ABW08501 ABW08502 AI134260 AI134638 AI402280 AW940421 AY069099 BG633525 CL528268 CZ470400 CZ475247 CZ475248 CZ475957 CZ478742 CZ487889 U26939 U26940 Entrez Gene - A searchable database of RefSeq genes. • 39041 UniProtKB/Swiss-Prot • P48610
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glutamine synthetase/guanido kinase, catalytic domain (IPR014746) ATP:guanido phosphotransferase (IPR000749) ATP:guanido phosphotransferase, N-terminal (IPR022413) ATP:guanido phosphotransferase, catalytic domain (IPR022414) ATP:guanido phosphotransferase active site (IPR022415)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64445 DroID - A comprehensive database of gene and protein interactions. • FBgn0000116 DRSC - Results from RNAi screens. • FBgn0000116 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000116 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32031-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000116 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39041 InParanoid A subset of ortholog calls from InParanoid. • AAEL009185-PA Aedes aegypti (mosquito) AGAP005627-PA Anopheles gambiae (mosquito) NP_001011603.1 Apis mellifera (honey bee) 129321 Branchiostoma floridae (lancelet) BGIBMGA005812-PA Bombyx mori (silk worm) ENSBTAP00000004079 Bos taurus (bovine) CN02590 Caenorhabditis brenneri (small nematode) CBP29209 Caenorhabditis briggsae (nematode) CE37112 Caenorhabditis elegans (worm) ENSCAFP00000032827 Canis familiaris (dog) ENSCINP00000022369 Ciona intestinalis (sea squirt) JA13507 Caenorhabditis japonica (nematode) CPIJ007538 Culex pipens (mosquito) ENSCPOP00000016471 Cavia porcellus (guinea pig) RP20426 Caenorhabditis remanei (nematode) ENSCSAVP00000016889 Ciona savignyi (sedentary tunicate) 149896 Capitella spl (polychaete worm) 220693 Daphnia pulex (daphnia) ENSDARP00000037871 Danio rerio (zebra fish) ENSECAP00000019848 Equus caballus (horse) ENSGACP00000016500 Gymnopilus aculeatus (mushroom) ENSGALP00000018743 Gallus gallus (chicken) ENSP00000299198 Homo sapiens (human) 183253 Lottia gigantea (owl limpet) 21418 Monocosta brevicollis (choanoflagellate) ENSMODP00000016895 Monodelphis domestica (gray opossum) ENSMMUP00000024964 Macaca mulatta (rhesus monkey) ENSMUSP00000003643 Mus musculus (house mouse) 215593 Nematostella vectensis (starlet anemone) XP_001607122.1 Nasonia vitripennis (wasp) ENSOANP00000001217 Ornithorynchus anatinus (platypus) ENSOANP00000023266 Ornithorynchus anatinus (platypus) ENSORLP00000022417 Oryzias latipes (japanese killifish) PHUM005636-PA Pediculus humanus (human body louse) PP10805 Pristionchus pacificus (nematode) ENSPPYP00000011314 Pongo pygmaeus (orangutan) 71216 Phytophthora ramorum (sudden oak death pathogen) 108967 Phytophthora sojae (root rot pathogen) ENSPTRP00000011527 Pan troglodytes (chimpanzee) ENSRNOP00000022895 Rattus norvegicus (norway rat) XP_001176159.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001181395.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198416.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971800.2 Tribolium castaneum (red flour beetle) Tc00.1047053507241.30 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022170 Tetraodon nigroviridis (green spotted pufferfish) 263946 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004007 Takifugu rubripes (pufferfish Takifugu) 3700.m00194 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000041410 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39041 modMine - Data generated by the modENCODE project. • FBgn0000116 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12741 LH12999 ISCW021028 ISCW020252 FBgn0238532 FBgn0225827 FBgn0200042 FBgn0179755 JGI_V11_220693 FBgn0076639 FBgn0152684 FBgn0139303 FBgn0123373 FBgn0107294 FBgn0100504 CPIJ007538 BGIBMGA005812 GB10973 AGAP012924 AGAP005627 AAEL009185 PB23384 PHUM616180 GLEAN_13596 GLEAN_02600
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	AK (Walter et al., 2000, James and Collier, 1990, Ghosh and Collier, 2008) AK-1 (Choudhary et al., 1992) ArgK (Kai et al., 2005, Wyss et al., 1995, Brandt et al., 2008, Franco et al., 2011) argk (Freeman et al., 2003) argK (Wang et al., 1996) Argk (Altenhein et al., 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Ghosh and Collier, 2008, Wasbrough et al., 2010, Hazelett et al., 2009, Reumer et al., 2009) ARK (Collier, 1990, Munneke and Collier, 1988) CG4929 (Munier et al., 2004, Artero, 2001.7.23, ) CG5173 (Artero, 2001.7.23, ) CG32031 (Karlsson et al., 2004, Quinones-Coello, 2007, Lebo et al., 2009, Perkins et al., 2009, Pinnola et al., 2007, Reumer et al., 2009, Ni et al., 2011.7.19, Cammarato et al., 2011)
Name Synonym	Arginine kinase (Vernon et al., 1998, Ghosh and Collier, 2008, Lebo et al., 2009, Hurlbut et al., 2009, Robinson et al., 2010, Reumer et al., 2009, Cammarato et al., 2011) arginine kinase (Collier et al., 2007, Wang et al., 2006) insect intestinal mucin iim22 (Zou et al., 2000)
Secondary FlyBase IDs
	FBgn0035958 FBgn0052031
References ( 74 )
Generate a list of	All references relating to this gene ( 74 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 11 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 3 )
	Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Robinson et al., 2010, Mech. Ageing Dev. 131(9): 584--590 Insights into aging through measurements of the Drosophila proteome as a function of temperature. [FBrf0211959] Show all research papers ...