• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\arm

General Information
Symbol	Dmel\arm	Species	D. melanogaster
Name	armadillo	Annotation symbol	CG11579
Feature type	protein_coding_gene	FlyBase ID	FBgn0000117
Gene Model Status	Current	Stock availability	36 publicly available
Also Known As	β-cat, EG:86E4.6, βcat
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.2
Cytogenetic map	2B14-2B14	Sequence location	X:1,785,434..1,794,673 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene armadillo is referred to in FlyBase by the symbol Dmel\arm (CG11579, FBgn0000117). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II transcription coactivator activity; kinase binding; transcription coactivator activity. There is experimental evidence for 28 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular component organization or biogenesis; regulation of developmental process; regulation of cellular macromolecule biosynthetic process; sensory organ development; cell adhesion; organ morphogenesis; open tracheal system development; multicellular organismal reproductive process; growth; cell fate determination; larval chitin-based cuticle development; epithelial cell type specification, open tracheal system. 184 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; abdominal ventral denticle belt; female germline cyst; primordium; embryonic/larval neuron; external compound sense organ; nervous system; embryonic/larval tracheal system. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Armadillo; Armadillo-like helical; Armadillo-type fold; Beta-catenin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult fat body, adult spermathecae, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1629020_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of arm. Gene sequence location is X:1785434..1794673.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	arm: armadillo Homozygous lethal; embryonic segmentation defective by time of germ-band shortening; naked cuticle ordinarily comprising the posterior two thirds of each segment replaced by mirror-image duplication of the anteriorly situated denticle belt; strong alleles delete first denticle row in abdominal segments. May have dorsal hole in cuticle. Embryonic CNS development quasi normal (Patel, Schafer, Goodman, and Holmgren, 1989, Genes Dev. 3: 890-904). Autonomous at the level of single cells as shown by denticulate clones of homozygous cells in the naked cuticle of abdominal segments in arm/+ embryos (Wieschaus and Riggleman, 1987, Cell 49: 177-84). Clones of homozygous female germ cells arrested at stage 10 of oogenesis (Wieschaus and Noell, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 63-73). An exception is arm8 for which progeny from homozygous germ-line clones have been recovered (Klingsmith et al.). Cell lethal in imaginal discs; although clones of homozygous cells not observed in adults, their formation seems to engender mirror-image duplications, which are not seen in response to homozygosing other cuticular cell lethals (Wieschaus). Transcript found with minor fluctuations in amount, in all cell types at all stages in development (Riggleman, Wieschaus, and Schedl, 1989, Genes Dev. 3: 96-113).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Gurunathan et al., 2004, BMC Bioinformatics 5: 202 Bakal et al., 2007, Science 316(5832): 1753--1756
FB2012_01	Controlled Vocabulary Terms RNA polymerase II transcription coactivator activity References Yasugi et al., 2010, Development 137(19): 3193--3203 Badouel et al., 2009, Dev. Cell 16(3): 411--420 Albornoz et al., 2008, Gene Expr. Patterns 8(6): 443--451 Tripura et al., 2011, Int. J. Dev. Biol. 55(6): 583--590 Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 Brodland et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(51): 22111--22116 Tolwinski, 2009, Genetics 181(3): 1169--1173 Schiemann et al., 2010, Biochem. Biophys. Res. Commun. 402(4): 699--704 Sequence features BKN22626 HFA18738
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2B14-2B14   Limits computationally determined from genome sequence between P{EP}EP1444&P{EP}CG14818EP1190 and P{EP}CG3600EP1232
Experimentally Determined Cytological Location
Cytogenetic map Notes References 2B-2B   (determined by in situ hybridisation) 2B7--10 (determined by in situ hybridisation) 2B1--14 (determined by in situ hybridisation) 2B13--18 (determined by in situ hybridisation)   (Peter et al., 2002) 2B15-2B15     (Schaefer, 2000.11.10) 2B-2B   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 2B7-2B10   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.10) 2B15-2B15   (determined by in situ hybridisation)   (Riggleman et al., 1989)
Experimentally Determined Recombination Data
Location	1-1.2 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\arm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) arm-RA FBtr0089991  NM_057318   3136   843 arm-RB FBtr0089989  NM_134273   3220   843 arm-RC FBtr0089990  NM_166912   3123   721 arm-RD FBtr0089992  NM_057317   3121   843 arm-RE FBtr0089988  NM_206605   3202   843
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein arm-PA   FBpp0089034   91.2   843   5.30     NP_476666   AAF45687 arm-PB   FBpp0089032   91.2   843   5.30     NP_599100   AAF45688 arm-PC   FBpp0089033   79.3   721   6.32     NP_726775   AAN09064 arm-PD   FBpp0089035   91.2   843   5.30     NP_476665   AAF45686 arm-PE   FBpp0089031   91.2   843   5.30     NP_996328   AAS65246
Additional Polypeptide Data & Comments
Reported size (kDa)	843 (aa); 93 (kD) (Peifer and Wieschaus, 1990) 721 (aa); 105-115, 82 (kD observed) (Loureiro and Peifer, 1998) 91 (kD) (Riggleman et al., 1990)
Comments	arm protein is phosphorylated on both serine or threonine and on tyrosine residues. The level of phosphorylation varies in different tissues and at different times of development. Phosphorylation of arm protein is negatively regulated by wg protein. sgg protein is required for arm protein phosphorylation. (Hamada et al., 1999) The neural form of arm is phosphorylated on tyrosine residues. Only a small fraction of the protein appears to be tyrosine-phosphorylated. (Loureiro and Peifer, 1998) Antibodies were generated against the carboxy-terminal 43 amino acids. The antibody does not recognize the shorter "neural" form of arm protein. (Loureiro and Peifer, 1998) The majority of arm protein in vivo is part of a membrane-associated complex containing α-Cat and an unidentified glycoprotein. (Peifer, 1993) Antibodies raised against arm protein recognize a single protein in canine (MDCK), mouse (3T3), African green monkey (COS-7), and Xenopus (A6) cultured cells. The cross-reacting proteins in A6 and MDCK cells were shown to be β-catenin. (Peifer et al., 1992)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Armadillo-like helical (IPR011989) Beta-catenin (IPR013284) Armadillo-type fold (IPR016024)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201402   AA201417   AA201662   AA202190   AA202622   AA202866   AA246352   AA246596   AA263981   AA264588   AA390401   AA390561   AA391084   AA391346   AA392688   AA392775   AA438333   AA438590   AA438754   AA438856   AA438928   AA438981   AA439308   AA439353   AA440469   AA441124   AA441412   AA441453   AA441595   AA567482   AA695432   AA695433   AA696762   AA696831   AA698297   AA735374   AA735407   AA735586   AA735659   AA735719   AA801659   AA816359   AA817093   AA817256   AA817498   AA817543   AA820241   AA820341   AA820405   AA940658   AA940744   AA940891   AA940989   AA941157   AA941206   AA942105   AA942246   AA942319   AA942498   AA942655   AA949071   AA949426   AA949563   AA949809   AA950520   AA950551   AA950587   AA950684   AA950714   AA951115   AA951468   AA951685   AA951861   AA951994   AA978943   AA978983   AA979033   AA979080   AA979298   AA979629   AE014298 AAF45686   AE014298 AAF45687   AE014298 AAF45688   AE014298 AAN09064   AE014298 AAS65246   AF001213 AAB58731   AF345663 AAK72233   AF345664 AAK72234   AF345665 AAK72235   AF345666 AAK72236   AF345667 AAK72237   AF345668 AAK72238   AF345669 AAK72239   AF345670 AAK72240   AF345671 AAK72241   AF345672 AAK72242   AF345673 AAK72243   AF345674 AAK72244   AF345675 AAK72245   AI062364   AI063030   AI064036   AI064095   AI106865   AI113768   AI114110   AI133981   AI134507   AI134944   AI135061   AI257135   AI258312   AI259864   AI292518   AI294042   AI294840   AI295357   AI386867   AI388533   AI389246   AI389692   AI389771   AI389810   AI403025   AI403770   AI404845   AI404929   AI405828   AI454996   AI455073   AI455594   AI455781   AI455992   AI456145   AI456156   AI456244   AI456517   AI456885   AI456973   AI457018   AI512037   AI512116   AI512216   AI512511   AI512650   AI512752   AI512793   AI513060   AI514119   AI514392   AI515406   AI515705   AI515739   AI515769   AI516204   AI516225   AI516405   AI516466   AI516535   AI518294   AI518325   AI518575   AI518713   AI519065   AI519249   AI519254   AI519595   AI520282   AI520291   AI520297   AI520609   AI533056   AI533423   AI533424   AI534628   AI534698   AI541595   AI541707   AI542062   AI542153   AI542820   AI542988   AI543015   AI543126   AI543556   AI543575   AI543717   AI543888   AI544137   AI546617   AI546711   AJ300028   AJ300264   AL021086 CAA15935   AL021106 CAA15946   AW942665   AY118525 AAM49894   BF488320   BF493462   BF493463   BF494829   BF498056   BG632538   BG636769   BG639113   BI141794   BI161810   BI161967   BI162450   BI162510   BI162569   BI162570   BI162917   BI163335   BI164094   BI164204   BI164437   BI165331   BI165472   BI165772   BI165794   BI166176   BI166892   BI166969   BI168017   BI168032   BI168052   BI168241   BI168254   BI168418   BI169091   BI169334   BI169459   BI169729   BI170259   BI170263   BI171986   BI172014   BI172079   BI172536   BI172612   BI173002   BI173157   BI173471   BI173682   BI173747   BI212500   BI212626   BI213006   BI213126   BI214002   BI214478   BI214826   BI216199   BI228022   BI228523   BI228741   BI229028   BI229190   BI229220   BI231030   BI231636   BI232034   BI232068   BI232110   BI232218   BI232440   BI232543   BI233197   BI234507   BI234543   BI234935   BI235060   BI235085   BI235186   BI235236   BI235286   BI235589   BI236106   BI236540   BI236620   BI236852   BI238039   BI238060   BI238593   BI240564   BI241183   BI241778   BI242159   BI242767   BI242909   BI243141   BI243545   BI352129   BI352254   BI353139   BI355979   BI356193   BI357176   BI357522   BI361686   BI362571   BI363093   BI363350   BI363959   BI364933   BI365515   BI366215   BI366444   BI366564   BI368663   BI369453   BI370769   BI371066   BI371459   BI372202   BI372396   BI372397   BI373241   BI373895   BI374685   BI375189   BI481881   BI482516   BI484144   BI484225   BI484697   BI485723   BI486667   BI486889   BI566485   BI567201   BI576772   BI577467   BI579140   BI579708   BI583742   BI587335   BI606490   BI606687   BI608345   BI611643   BI615452   BI615595   BI615878   BI622559   BI626695   BI632439   BI633233   BI635154   BI636241   BI637341   BI637454   BI638223   BI638371   BI638662   BI638784   BI639467   BI639683   BI639952   BI640078   BI640985   BP550271   BP550272   CK131842   CK132882   CK605461   CK605462   CK657349   CK657936   CK658023   CK658362   CK659781   CK661539   CL868542   CO188448   CO190493   CO262561   CO270737   CO277772   CO294679   CO295649   CO297864   CO299314   CO301284   CO303961   CO308340   CO310628   CO310680   CO311276   CO311473   CO317185   CO318624   CO320367   CO324822   CO327344   CO327835   CO329426   CO329523   CO329742   CO337156   CO341314   CS419459   CZ482354   DN154146   EC051232   EC051237   EC053734   EC055319   EC065902   EC070460   EC070461   EC076107   EC076171   EC078240   EC078623   EC080860   EC085680   EC086831   EC090055   EC195034   EC201266   EC202093   EC203721   EC212054   EC216187   EC217274   EC223829   EC225437   EC226786   EC231853   EC233050   EC236848   EC236890   EC238593   EC239332   EC239368   EC244572   EC246659   EC247415   EC250143   EC251104   EC258268   EC261521   EL871844   EL871845   EL873927   EL874171   EL881381   EL881382   EL882717   EL882718   EL882834   EL883019   EL883020   ES695678   ES696430   ES696448   ES696450   ES696452   ES696455   ES696456   ES696459   ES696460   ES696463   ES696471   ES696472   ES696476   ES696477   ES696481   ES696936   EV575966   EV582146   EV597234   GH738922   GH739123   GH740095   GH740497   GH740768   GH741046   GH741611   GH741921   GH742693   GH743367   GH743475   GH744107   GH744581   GH744933   GH745261   GH745768   GH746351   GH761587   GH764719   GH765135   GH767314   GH768698   GH768801   GH768817   GH769447   GH769655   GH886231   GH941817   GH943932   GH945679   GH946105   GH946443   GH947030   GH947776   GH947866   GH948058   GH949583   GH950812   GH952291   GH952925   GH953732   GH954502   GH955898   GH956935   GH958460   GH960744   GH960882   GH961165   GH961672   GH961731   GH962107   GH962371   GH963208   GH963463   GH964122   GH964401   GH964574   GH965671   GH965915   GH966796   GH967205   GH967580   GH967687   GH968176   GH968375   GH969022   GH969549   GH969831   GH970031   GH970379   GH971226   GH972207   GH973035   GH974957   GH975152   GH978381   GH978434   GH980370   GH980515   GH980856   GH980874   GH981427   GH981548   GH981786   GH982070   GH982150   GH982503   GH982515   GH983558   X54468 CAA38350   Z32098
UniProtKB/Swiss-Prot	P18824
UniProtKB/TrEMBL	Q95NY7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral midline   (Riggleman et al., 1990) presumptive embryonic/larval central nervous system   (Riggleman et al., 1990, Peifer and Wieschaus, 1990) posterior embryonic/larval midgut   (Riggleman et al., 1990) embryonic stage 9   labral segment   (Riggleman et al., 1990) proctodeum   (Riggleman et al., 1990) embryonic stage 13   Malpighian tubule   (Riggleman et al., 1990) proventriculus   (Riggleman et al., 1990) embryonic stage 13 -- 16   supraesophageal ganglion   (Riggleman et al., 1990) sense organ   (Riggleman et al., 1990) larval stage   embryonic/larval digestive system   (Riggleman et al., 1990) imaginal disc   (Riggleman et al., 1990) optic lobe   (Peifer and Wieschaus, 1990) ventral nerve cord   (Peifer and Wieschaus, 1990) embryonic/larval muscle system   (Riggleman et al., 1990) embryonic/larval salivary gland   (Peifer and Wieschaus, 1990) eye-antennal disc   (Peifer and Wieschaus, 1990) third instar larval stage   embryonic/larval salivary gland   (Peifer et al., 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   mesoderm   (Riggleman et al., 1990) tracheal pit   (Riggleman et al., 1990) embryonic/larval foregut   (Riggleman et al., 1990) peripheral nervous system   (Riggleman et al., 1990) presumptive embryonic/larval peripheral nervous system   (Loureiro and Peifer, 1998) tracheal system   (Loureiro and Peifer, 1998) embryonic epidermis | restricted   (Thompson, 2004) lateral ectoderm   • adherens junction (Kutchma et al., 2007)   (Peifer et al., 1991) embryonic stage | late   midline glial cell   (Loureiro and Peifer, 1998) longitudinal connective   (Loureiro and Peifer, 1998) motor neuron of segmental nerve   (Loureiro and Peifer, 1998) motor neuron of intersegmental nerve   (Loureiro and Peifer, 1998) embryonic stage 5   furrow canal | restricted   (Thomas and Wieschaus, 2004) embryonic stage 8 -- 10   organism | segment polarity expression pattern   (Hamada and Bienz, 2002) embryonic cycle 14     • plasma membrane | lateral (Lecuit et al., 2002) embryonic stage 9   stomodeum   (Riggleman et al., 1990) antennal segment   (Riggleman et al., 1990) embryonic stage 11   ventral ectoderm | segmentally repeated   (Belenkaya et al., 2002) embryonic stage 12 -- 17   embryonic foregut   • apical plasma membrane (Fuss et al., 2004) embryonic stage 13   embryonic/larval anus   (Riggleman et al., 1990) embryonic/larval posterior spiracle   (Riggleman et al., 1990) embryonic/larval hindgut   (Riggleman et al., 1990) embryonic stage 13 -- 14   gonad | restricted   • plasma membrane (Jenkins et al., 2003) embryonic stage 13 -- 16   ventral nerve cord   (Riggleman et al., 1990) embryonic stage 14 -- 15   keyhole structure   • apical plasma membrane (Fuss et al., 2004) embryonic stage 17   gonad | anterior & restricted   • plasma membrane (Jenkins et al., 2003) Comment:male embryonic proventriculus   • apical plasma membrane (Fuss et al., 2004) larval stage   embryonic/larval salivary gland   (Riggleman et al., 1990) embryonic/larval brain   (Riggleman et al., 1990) imaginal disc   (Loureiro and Peifer, 1998) ventral midline   (Loureiro and Peifer, 1998) third instar larval stage   imaginal disc   (Peifer et al., 1991) wing disc   • apicolateral plasma membrane (Arquier et al., 2001) P-stage   photoreceptor cell   • adherens junction of rhabdomere (Matsuo et al., 1999) pupal stage   retina   • plasma membrane (Hayashi and Carthew, 2004) adult stage | male   testis | apical   (Schulz et al., 2004) oogenesis & adult stage | female   nurse cell   (Peifer et al., 1993) oocyte   (Peifer et al., 1993) adult stage | female & oogenesis   follicle cell   (Peifer et al., 1993) spermatogenesis   male germline stem cell | surrounding   (Schulz et al., 2004) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   ventral nerve cord commissure   (Loureiro and Peifer, 1998) presumptive embryonic/larval peripheral nervous system   (Loureiro and Peifer, 1998) embryonic stage | late & larval stage   neuron   • axon (Loureiro and Peifer, 1998) embryonic stage 13 -- 17     (Loureiro and Peifer, 1998) adult stage   head   (Loureiro and Peifer, 1998)
Additional Descriptive Data
	arm protein localizes to the apical surfaces of cells. (Peifer et al., 1991) The localization of arm protein often parallels the location of adherens junctions. (Riggleman et al., 1990, Peifer et al., 1993) The intracellular distribution of arm protein in imaginal discs, salivary glands and larval brain was described. In salivary glands, arm protein is concentrated at the junctions between cells and is punctate on the apical surface. It is uniformly distributed on the lateral surfaces. arm protein distribution is also polarized in imaginal discs where high levels are restricted to the apical side. In the embryonic CNS and larval brain, arm protein is enriched in fiber tracts and there is less in the cell bodies of neurons. In the eye disc, arm protein accumulates fairly uniformly on the membranes separating cells in the undifferentiated region. As the morphogenetic furrow passes, arm expression appears to increase. Strong protein accumulation is seen in a star-shaped pattern on membranes where cells in the precluster abut one another but not at junctions with undifferentiated cells. arm protein often colocalizes with actin. (Noordermeer et al., 1992, Peifer and Wieschaus, 1990) arm protein localizes to junctions resembling vertebrate adherens junctions. (Loureiro and Peifer, 1998, Peifer, 1993) Protein is detected in lateral membrane of the cellularizing embryo and is not detected apically. (Lecuit et al., 2002) arm protein expression was studied during oogenesis. arm protein is asymmetrically localized within follicle cells. Within each follicle cell, it accumulates heavily on the lateral cell surface near the apical end abutting the germ cells. It is less abundant on the rest of the follicle cell-follicle cell interface. Staining is the heaviest in a band around the follicle cell near the interface between the lateral and apical surfaces. The majority of arm protein in the ovary is found in the follicle cells but it is also observed in n rse cells and in the oocyte. Accumulation is germ cells is first seen at the anterior tip of the germarium. Similar intense staining is seen at the anterior tip of the testis. As with follicle cells, arm protein accumulates near or at the cell surface of germ cells but is not concentrated at any one position along the cell-cell interface. Protein accumulation appears to be heaviest where the nurse cell-nurse cell junction abuts the overlying follicle cells. It also accumulates in the cortical region of the oocyte. arm protein accumulates differentially in different follicle cells. Polar ollicle cells show more intense arm staining. (Peifer et al., 1993) arm protein is observed outlining clusters of male germline stem cells. (Schulz et al., 2004) In stage 13 embryos,arm protein expression is detected on the cell membrane of both somatic germline precursor cells as well as the germline cells in both males and females. This localization is concurrent with the processes of ensheathment and coalescence of the developing gonad. In stage 17 male embryos, arm protein is concentrated in the anterior of the gonad in the region corresponding to the testes hub. (Jenkins et al., 2003) high levels of wg protein induce accumulation of arm protein in stripes of cells. (Thompson, 2004) The 82kD "neural" form of arm protein is first detected on western blots in germ band retracted embryos. It is the predominant form in germ band retracted embryos and is abundant in adult head. The neural form of arm protein is detected by immunolocalization in the longitudinal and commissural tracts in the embryonic CNS and in motor neurons of the segmental and intersegmental nerves as they exit the CNS. It is also detected in the PNS. In the larval CNS, it accumulates along axon tracts. (Loureiro and Peifer, 1998)
Marker for
	apicolateral plasma membrane
Subcellular Localization
CV Term	intercellular junction (Peifer, 1993) cell-cell adherens junction (Peifer et al., 1993) plasma membrane intercellular junction (Peifer and Wieschaus, 1990) plasma membrane | apical (Peifer et al., 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000117    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000117 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000117 expression level Developmental Stage   Expression Level embryo 00-02hr    18295 embryo 02-04hr    38225 embryo 04-06hr    59310 embryo 06-08hr    55080 embryo 08-10hr    40818 embryo 10-12hr    43251 embryo 12-14hr    27968 embryo 14-16hr    28921 embryo 16-18hr    19257 embryo 18-20hr    14357 embryo 20-22hr    13768 embryo 22-24hr    12611 larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9    11018 white prepupae new    13501 white prepupae 12hr    15084 white prepupae 24hr    21768 pupae 2d postWPP    17940 pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day    10120 adult female 30day    10896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18295) embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  (19257) embryo 18-20hr  (14357) embryo 20-22hr  (13768) embryo 22-24hr  (12611) larva L1  (6536) larva L2  (5520) larva L3 12hr old  (3878) larva L3 puffstage 1-2  (5664) larva L3 puffstage 3-6  (8943) larva L3 puffstage 7-9  (11018) white prepupae new  (13501) white prepupae 12hr  (15084) white prepupae 24hr  (21768) pupae 2d postWPP  (17940) pupae 3d postWPP  (9914) pupae 4d postWPP  (5113) adult male 01day  (5035) adult male 05day  (5248) adult male 30day  (5178) adult female 01day  (8956) adult female 05day  (10120) adult female 30day  (10896) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18295) embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  (19257) embryo 18-20hr  (14357) embryo 20-22hr  (13768) embryo 22-24hr  (12611) larva L1  (6536) larva L2  (5520) larva L3 12hr old  (3878) larva L3 puffstage 1-2  (5664) larva L3 puffstage 3-6  (8943) larva L3 puffstage 7-9  (11018) white prepupae new  (13501) white prepupae 12hr  (15084) white prepupae 24hr  (21768) pupae 2d postWPP  (17940) pupae 3d postWPP  (9914) pupae 4d postWPP  (5113) adult male 01day  (5035) adult male 05day  (5248) adult male 30day  (5178) adult female 01day  (8956) adult female 05day  (10120) adult female 30day  (10896) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (18295) embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  (19257) embryo 18-20hr  (14357) embryo 20-22hr  (13768) embryo 22-24hr  (12611) larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9  (11018) white prepupae new  (13501) white prepupae 12hr  (15084) white prepupae 24hr  (21768) pupae 2d postWPP  (17940) pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day  10120 adult female 30day  (10896) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18295 embryo 02-04hr    38225 embryo 04-06hr    59310 embryo 06-08hr    55080 embryo 08-10hr    40818 embryo 10-12hr    43251 embryo 12-14hr    27968 embryo 14-16hr    28921 embryo 16-18hr    19257 embryo 18-20hr    14357 embryo 20-22hr    13768 embryo 22-24hr    12611 larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9    11018 white prepupae new    13501 white prepupae 12hr    15084 white prepupae 24hr    21768 pupae 2d postWPP    17940 pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day    10120 adult female 30day    10896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000117 expression level Developmental Stage   Expression Level embryo 00-02hr    18295 embryo 02-04hr    38225 embryo 04-06hr    59310 embryo 06-08hr    55080 embryo 08-10hr    40818 embryo 10-12hr    43251 embryo 12-14hr    27968 embryo 14-16hr    28921 embryo 16-18hr    19257 embryo 18-20hr    14357 embryo 20-22hr    13768 embryo 22-24hr    12611 larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9    11018 white prepupae new    13501 white prepupae 12hr    15084 white prepupae 24hr    21768 pupae 2d postWPP    17940 pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day    10120 adult female 30day    10896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (18295) embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  (19257) embryo 18-20hr  (14357) embryo 20-22hr  (13768) embryo 22-24hr  (12611) larva L1  (6536) larva L2  (5520) larva L3 12hr old  (3878) larva L3 puffstage 1-2  (5664) larva L3 puffstage 3-6  (8943) larva L3 puffstage 7-9  (11018) white prepupae new  (13501) white prepupae 12hr  (15084) white prepupae 24hr  (21768) pupae 2d postWPP  (17940) pupae 3d postWPP  (9914) pupae 4d postWPP  (5113) adult male 01day  (5035) adult male 05day  (5248) adult male 30day  (5178) adult female 01day  (8956) adult female 05day  (10120) adult female 30day  (10896) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (18295) embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  (19257) embryo 18-20hr  (14357) embryo 20-22hr  (13768) embryo 22-24hr  (12611) larva L1  (6536) larva L2  (5520) larva L3 12hr old  (3878) larva L3 puffstage 1-2  (5664) larva L3 puffstage 3-6  (8943) larva L3 puffstage 7-9  (11018) white prepupae new  (13501) white prepupae 12hr  (15084) white prepupae 24hr  (21768) pupae 2d postWPP  (17940) pupae 3d postWPP  (9914) pupae 4d postWPP  (5113) adult male 01day  (5035) adult male 05day  (5248) adult male 30day  (5178) adult female 01day  (8956) adult female 05day  (10120) adult female 30day  (10896) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  18295 embryo 02-04hr  (38225) embryo 04-06hr  (59310) embryo 06-08hr  (55080) embryo 08-10hr  (40818) embryo 10-12hr  (43251) embryo 12-14hr  (27968) embryo 14-16hr  (28921) embryo 16-18hr  19257 embryo 18-20hr  14357 embryo 20-22hr  13768 embryo 22-24hr  12611 larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9  11018 white prepupae new  13501 white prepupae 12hr  15084 white prepupae 24hr  (21768) pupae 2d postWPP  17940 pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day  10120 adult female 30day  10896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18295 embryo 02-04hr    38225 embryo 04-06hr    59310 embryo 06-08hr    55080 embryo 08-10hr    40818 embryo 10-12hr    43251 embryo 12-14hr    27968 embryo 14-16hr    28921 embryo 16-18hr    19257 embryo 18-20hr    14357 embryo 20-22hr    13768 embryo 22-24hr    12611 larva L1    6536 larva L2    5520 larva L3 12hr old    3878 larva L3 puffstage 1-2    5664 larva L3 puffstage 3-6    8943 larva L3 puffstage 7-9    11018 white prepupae new    13501 white prepupae 12hr    15084 white prepupae 24hr    21768 pupae 2d postWPP    17940 pupae 3d postWPP    9914 pupae 4d postWPP    5113 adult male 01day    5035 adult male 05day    5248 adult male 30day    5178 adult female 01day    8956 adult female 05day    10120 adult female 30day    10896 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000117    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000117 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult fat body, adult spermathecae, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000117 expression level Tissue   Expression Level Larval Central Nervous System    1559.625 Larval Midgut    1046.4 Larval Hindgut    997 Larval Malpighian Tubules    1168 Larval Fat Body    590.5 Larval Salivary Gland    1544.7 Larval Trachea    1310.375 Larval Carcass    823.6 Adult Head    1001.2 Adult Eye    1372.125 Adult Brain    1619.9 Adult Thoracic-Abdominal Ganglion    1297.6 Adult Crop    1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland    1858.3 Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1559.625) Larval Midgut  (1046.4) Larval Hindgut  (997) Larval Malpighian Tubules  (1168) Larval Fat Body  (590.5) Larval Salivary Gland  (1544.7) Larval Trachea  (1310.375) Larval Carcass  (823.6) Adult Head  (1001.2) Adult Eye  (1372.125) Adult Brain  (1619.9) Adult Thoracic-Abdominal Ganglion  (1297.6) Adult Crop  (1023.7) Adult Midgut  (771.5) Adult Hindgut  (802.8) Adult Malpighian Tubules  (813) Adult Fat Body    398.8 Adult Salivary Gland  (1858.3) Adult Heart  (551.15) Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary  (988) Adult Testis    217.6 Adult Male Accessory Gland  (811.2) Adult Carcass  (561.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1559.625) Larval Midgut  1046.4 Larval Hindgut    997 Larval Malpighian Tubules  (1168) Larval Fat Body    590.5 Larval Salivary Gland  (1544.7) Larval Trachea  (1310.375) Larval Carcass    823.6 Adult Head  1001.2 Adult Eye  (1372.125) Adult Brain  (1619.9) Adult Thoracic-Abdominal Ganglion  (1297.6) Adult Crop  1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland  (1858.3) Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1559.625 Larval Midgut    1046.4 Larval Hindgut    997 Larval Malpighian Tubules    1168 Larval Fat Body    590.5 Larval Salivary Gland    1544.7 Larval Trachea    1310.375 Larval Carcass    823.6 Adult Head    1001.2 Adult Eye    1372.125 Adult Brain    1619.9 Adult Thoracic-Abdominal Ganglion    1297.6 Adult Crop    1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland    1858.3 Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000117 expression level Tissue   Expression Level Larval Central Nervous System    1559.625 Larval Midgut    1046.4 Larval Hindgut    997 Larval Malpighian Tubules    1168 Larval Fat Body    590.5 Larval Salivary Gland    1544.7 Larval Trachea    1310.375 Larval Carcass    823.6 Adult Head    1001.2 Adult Eye    1372.125 Adult Brain    1619.9 Adult Thoracic-Abdominal Ganglion    1297.6 Adult Crop    1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland    1858.3 Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1559.625) Larval Midgut  (1046.4) Larval Hindgut  (997) Larval Malpighian Tubules  (1168) Larval Fat Body  590.5 Larval Salivary Gland  (1544.7) Larval Trachea  (1310.375) Larval Carcass  (823.6) Adult Head  (1001.2) Adult Eye  (1372.125) Adult Brain  (1619.9) Adult Thoracic-Abdominal Ganglion  (1297.6) Adult Crop  (1023.7) Adult Midgut  771.5 Adult Hindgut  802.8 Adult Malpighian Tubules  813 Adult Fat Body    398.8 Adult Salivary Gland  (1858.3) Adult Heart  551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary  (988) Adult Testis    217.6 Adult Male Accessory Gland  811.2 Adult Carcass  561.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1559.625 Larval Midgut  1046.4 Larval Hindgut    997 Larval Malpighian Tubules  1168 Larval Fat Body    590.5 Larval Salivary Gland  1544.7 Larval Trachea  1310.375 Larval Carcass    823.6 Adult Head  1001.2 Adult Eye  1372.125 Adult Brain  1619.9 Adult Thoracic-Abdominal Ganglion  1297.6 Adult Crop  1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland  (1858.3) Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1559.625 Larval Midgut    1046.4 Larval Hindgut    997 Larval Malpighian Tubules    1168 Larval Fat Body    590.5 Larval Salivary Gland    1544.7 Larval Trachea    1310.375 Larval Carcass    823.6 Adult Head    1001.2 Adult Eye    1372.125 Adult Brain    1619.9 Adult Thoracic-Abdominal Ganglion    1297.6 Adult Crop    1023.7 Adult Midgut    771.5 Adult Hindgut    802.8 Adult Malpighian Tubules    813 Adult Fat Body    398.8 Adult Salivary Gland    1858.3 Adult Heart    551.15 Adult VirginFemale Spermatheca    369.8 Adult InseminatedFemale Spermatheca    414.7 Adult Ovary    988 Adult Testis    217.6 Adult Male Accessory Gland    811.2 Adult Carcass    561.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1001.2   NA  Eye    1372.125   NA  Brain    1619.9   1559.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1297.6   NA  Crop    1023.7   1046.4  Midgut    771.5   997  Hindgut    802.8   1168  Malpighian Tubules    813   590.5  Fat Body    398.8   1544.7  Salivary Gland    1858.3   NA  Heart    551.15   1310.375  Trachea    NA   NA  VirginFemale Spermatheca    369.8   NA  InseminatedFemale Spermatheca    414.7   NA  Ovary    988   NA  Testis    217.6   NA  Male Accessory Gland    811.2   823.6  Carcass    561.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000117 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11579-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL429BD armGS1141 lethal, with Scer\GAL4c355 armGS1141 lethal, with Scer\GAL4hs.2sev armGS1141 lethal | adult stage armG0234 lethal | embryonic stage arm1 arm2 arm3 arm25B armG0192 lethal | embryonic stage, with Scer\GAL4e22c armScer\UAS.T:Hsap\MYC,T:Xlae\Ncad lethal | embryonic stage | heat sensitive arm1 lethal | embryonic stage | recessive arm1 arm8 armEH243 lethal | embryonic stage | recessive | segment polarity expression pattern arm1 arm4 lethal | embryonic stage | segment polarity expression pattern arm2 arm2a9 arm3 arm4 lethal | embryonic stage | segment polarity expression pattern | heat sensitive arm2 arm3 arm5 arm6 arm13-17 arm25B arm#2 lethal | germline clone arm1 arm043A01 lethal | heat sensitive arm17-114 lethal | larval stage armG0234 lethal | pharate adult stage armG0234 lethal | prepupal stage armG0234 lethal | pupal stage arm8 armG0234 lethal | pupal stage | heat sensitive arm8 lethal | pupal stage | recessive armF1α lethal | recessive armG0192 armL51 armPG98 armPG120 armPL27 semi-lethal, with Scer\GAL4dpp.blk1 armGS1141 semi-lethal | female armG0410 semi-lethal | male armG0410 semi-lethal | recessive armG0234 viable armEY15565 armT:Hsap\MYC,T:Hsap\CAAX viable, with Scer\GAL4e22c armS2.Scer\UAS.T:Hsap\MYC viable, with Scer\GAL4pnr-MD237 armGD1372 viable, with Scer\GAL4pros.PMG armS10.Scer\UAS.T:Hsap\MYC Sterility Allele fertile armEY15565 armT:Hsap\MYC,T:Hsap\CAAX Other Phenotypes Allele cell polarity defective arm2 armF1α cell shape defective arm3 hyperplasia | somatic clone, with Scer\GAL4αTub84B.PZ armΔ.Scer\UAS.T:Ivir\HA1 increased cell death armS44Y.GMR armS56F.GMR increased cell death, with Scer\GAL4GMR.PY armΔ.Scer\UAS.T:Ivir\HA1 mitotic cell cycle defective, with Scer\GAL4bbg-C96 armΔN.Scer\UAS planar polarity defective arm2 armF1α planar polarity defective, with Scer\GAL4arm.PS armact.Scer\UAS planar polarity defective | cell autonomous | somatic clone arm2 planar polarity defective | cell non-autonomous | recessive | somatic clone arm2 planar polarity defective | cell non-autonomous | somatic clone arm2 segment polarity phenotype arm2 size defective, with Scer\GAL4nub-AC-62, Scer\GAL80ts.αTub84B armS10.Scer\UAS.T:Hsap\MYC visible armact.hs.2sev armS44Y.GMR armS56F.GMR visible, with Scer\GAL4bbg-C96 armact.Scer\UAS visible, with Scer\GAL4bs-1348 armS10.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4Bx-MS1096 armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cWa armΔC.Scer\UAS visible, with Scer\GAL4dpp.blk1 armGS1141 armS10.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4en-e16E armScer\UAS.cWa visible, with Scer\GAL4GF1 armS10.Scer\UAS.T:Hsap\MYC armΔ.Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4GMR.PF armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cSa armScer\UAS.cWa visible, with Scer\GAL4GMR.PY armΔ.Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4HV1 armΔ.Scer\UAS.T:Ivir\HA1 visible, with Scer\GAL4nub-AC-62, Scer\GAL80ts.αTub84B armS10.Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4pnr-MD237 armGD1372 visible, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC visible | somatic clone, with Scer\GAL4Act5C.PI armΔ.Scer\UAS.T:Ivir\HA1 wild-type arm+mOa arm+mWa arm+t10.5 armS2.T:Hsap\MYC armS4.T:Hsap\MYC armS12.T:Hsap\MYC Phenotype manifest in Allele abdominal 1 ventral denticle belt arm25B abdominal 2 ventral denticle belt arm25B abdominal 3 ventral denticle belt arm25B abdominal 4 ventral denticle belt arm25B abdominal 5 ventral denticle belt arm25B abdominal 6 ventral denticle belt arm25B abdominal 7 ventral denticle belt arm25B abdominal sternite 1 arm8 armBCD7 abdominal sternite 2 arm8 armBCD7 abdominal sternite 3 arm8 armBCD7 abdominal sternite 4 arm8 armBCD7 abdominal sternite 5 arm8 armBCD7 abdominal sternite 6 arm8 armBCD7 abdominal sternite bristle | ectopic, with Scer\GAL4GF1 armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 1 founder cell | supernumerary, with Scer\GAL4Mef2.PR armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 1 founder cell | supernumerary, with Scer\GAL4twi.PB armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 2 founder cell | supernumerary, with Scer\GAL4Mef2.PR armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 2 founder cell | supernumerary, with Scer\GAL4twi.PB armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 3 founder cell | supernumerary, with Scer\GAL4Mef2.PR armS10.Scer\UAS.T:Hsap\MYC abdominal ventral acute muscle 3 founder cell | supernumerary, with Scer\GAL4twi.PB armS10.Scer\UAS.T:Hsap\MYC abdominal ventral denticle belt, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC abdominal ventral denticle belt | embryonic stage arm4 arm8 actin cytoskeleton | embryonic stage | maternal effect arm3 actin filament arm4 adherens junction arm3 adherens junction | germline clone arm043A01 adult cuticle & abdomen | somatic clone arm2 alula arm8 armBCD7 antennal disc, with Scer\GAL4dpp.blk1 armS10.Scer\UAS.T:Hsap\MYC border follicle cell arm4 cardial valve | precursor arm1 commissure arm8 cytoskeleton arm4 denticle, with Scer\GAL469B armS10.Scer\UAS.T:Hsap\MYC denticle, with Scer\GAL4unspecified armS10.Scer\UAS.T:Hsap\MYC denticle | ectopic arm2 denticle | ectopic, with arm2a9 armD164A.αTub84B.T:Hsap\MYC denticle | ectopic, with arm4 armS12.T:Hsap\MYC armS6.T:Hsap\MYC denticle | ectopic, with armD164A.αTub84B.T:Hsap\MYC arm2a9 denticle | ectopic, with armS6.T:Hsap\MYC arm4 denticle | ectopic, with armS12.T:Hsap\MYC arm4 denticle | ectopic, with Scer\GAL4arm.PS, arm1, armT:Hsap\MYC,T:Hsap\CAAX armΔ.Scer\UAS.T:Ivir\HA1 denticle | ectopic, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1, arm1 armT:Hsap\MYC,T:Hsap\CAAX denticle | ectopic, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1, armT:Hsap\MYC,T:Hsap\CAAX arm1 denticle | ectopic, with Scer\GAL4e22c armScer\UAS.T:Hsap\MYC,T:Ocun\nes denticle | ectopic | germline clone arm2 denticle | germline clone armF1α denticle | segment polarity expression pattern arm3 denticle belt arm2 arm3 arm4 armF1α denticle belt, with Scer\GAL469B armS10.Scer\UAS.T:Hsap\MYC denticle belt, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC denticle belt, with Scer\GAL4e22c armΔN.Scer\UAS armR.Scer\UAS armR.Scer\UAS.T:Hsap\MYC armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.T:Hsap\MYC,T:Ocun\nes armScer\UAS.T:Hsap\MYC,T:SV40\nls2 denticle belt, with Scer\GAL4GQ2 armΔ.Scer\UAS.T:Ivir\HA1 denticle belt, with Scer\GAL4h-1J3 armΔN.Scer\UAS denticle belt, with Scer\GAL4hs.PB armΔ.Scer\UAS.T:Ivir\HA1 denticle belt, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 armΔ.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC denticle belt | ectopic arm2 denticle belt | ectopic, with Scer\GAL4arm.PS armΔC.Scer\UAS denticle belt | germline clone, with Scer\GAL4arm.PS armScer\UAS.cWa denticle belt | segment polarity expression pattern arm3 denticle row 1, with Scer\GAL4en-e16E armS10.Scer\UAS.T:Hsap\MYC direct flight muscle, with Scer\GAL41151 armS10.Scer\UAS.T:Hsap\MYC dMP2 neuron arm4 dorsal closure embryo arm#2 arm2 arm25B arm2a9 arm3 arm4 arm6 dorsal denticle, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC dorsal fine hair | ectopic, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC dorsal fine hair | ectopic, with Scer\GAL4ptc-559.1 armS10.Scer\UAS.T:Hsap\MYC dorsal hair, with Scer\GAL4arm.T:Hsim\VP16 armS10.Scer\UAS.T:Hsap\MYC dorsal margin photoreceptor armact.hs.2sev dorsal margin photoreceptor | ectopic, with Scer\GAL4GMR.long armS10.Scer\UAS.T:Hsap\MYC dorsal mesothoracic disc & peripodial epithelium | somatic clone | cell autonomous, with Scer\GAL4αTub84B.PL armΔα.Scer\UAS dorsal row arm1 arm8 armBCD7 dorsal thick hair, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC dorsal trunk primordium arm4 egg | germline clone arm1 arm3 egg chamber arm3 egg chamber | germline clone arm1 embryo arm1 arm13-17 embryo | dorsal closure stage arm2 embryo | germline clone arm3 embryo | segment polarity expression pattern arm#2 arm1 arm13-17 arm2 arm25B arm2a9 arm3 arm4 arm5 arm6 arm8 armS11.T:Hsap\MYC armS12.T:Hsap\MYC armS15.T:Hsap\MYC armS5.T:Hsap\MYC armS6.T:Hsap\MYC embryonic/first instar larval cuticle arm1 arm2 arm3 arm4 arm8 armLM134 armS15.T:Hsap\MYC armS5.T:Hsap\MYC embryonic/first instar larval cuticle, with arm2a9 armD164A.αTub84B.T:Hsap\MYC embryonic/first instar larval cuticle, with arm4 armS12.T:Hsap\MYC armS6.T:Hsap\MYC embryonic/first instar larval cuticle, with armD164A.αTub84B.T:Hsap\MYC arm2a9 embryonic/first instar larval cuticle, with armS6.T:Hsap\MYC arm4 embryonic/first instar larval cuticle, with armS12.T:Hsap\MYC arm4 embryonic/first instar larval cuticle, with Scer\GAL469B armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle, with Scer\GAL4arm.PS armΔ.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, arm1, armT:Hsap\MYC,T:Hsap\CAAX armΔ.Scer\UAS.T:Ivir\HA1 embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, arm2, armT:Hsap\MYC,T:Hsap\CAAX armΔ.Scer\UAS.T:Ivir\HA1 embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, armT:Hsap\MYC,T:Hsap\CAAX armΔ.Scer\UAS.T:Ivir\HA1 embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1 armT:Hsap\MYC,T:Hsap\CAAX embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1, arm1 armT:Hsap\MYC,T:Hsap\CAAX embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1, arm2 armT:Hsap\MYC,T:Hsap\CAAX embryonic/first instar larval cuticle, with Scer\GAL4arm.PS, armΔ.Scer\UAS.T:Ivir\HA1, armT:Hsap\MYC,T:Hsap\CAAX arm1 arm2 embryonic/first instar larval cuticle, with Scer\GAL4da.G32 armΔ.Scer\UAS.T:Ivir\HA1 armScer\UAS.T:Hsap\MYC,T:SV40\nls2 embryonic/first instar larval cuticle, with Scer\GAL4e22c armR.Scer\UAS armR.Scer\UAS.T:Hsap\MYC armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.T:Hsap\MYC,T:Ocun\nes armScer\UAS.T:Hsap\MYC,T:SV40\nls2 embryonic/first instar larval cuticle, with Scer\GAL4GQ2 armΔ.Scer\UAS.T:Ivir\HA1 embryonic/first instar larval cuticle, with Scer\GAL4hs.PB armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle, with Scer\GAL4unspecified armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle, with Scer\GAL4αTub84B.PK armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle & denticle, with Scer\GAL4da.G32 armΔ.D164A.Scer\UAS.T:Hsap\MYC armΔ.K435E.Scer\UAS.T:Hsap\MYC armΔ.Scer\UAS.T:Hsap\MYC armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle & denticle | ectopic, with Scer\GAL4da.G32 armS10.D164A.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle & denticle belt, with Scer\GAL4da.G32 armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle | dorsal arm2a9 embryonic/first instar larval cuticle | dorsal, with Scer\GAL4arm.T:Hsim\VP16 armS10.Scer\UAS.T:Hsap\MYC embryonic/first instar larval cuticle | germline clone arm3 armF1α embryonic/first instar larval cuticle | germline clone, with Scer\GAL4arm.PS armScer\UAS.cWa embryonic/first instar larval cuticle | maternal effect arm043A01 arm2 embryonic/first instar larval cuticle | segment polarity expression pattern arm2 arm8 embryonic/first instar larval cuticle | ventral arm1 arm2 arm3 embryonic/first instar larval cuticle | ventral, with Scer\GAL4arm.PS armΔC.Scer\UAS embryonic/larval cuticle arm3 embryonic/larval dorsal branch arm2 embryonic/larval dorsal branch 10 arm4 embryonic/larval dorsal trunk arm2 arm4 arm8 embryonic/larval dorsal trunk, with arm4 armS14.T:Hsap\MYC embryonic/larval dorsal trunk, with armS14.T:Hsap\MYC arm4 embryonic/larval dorsal trunk, with Scer\GAL4btl.PS armS10.Scer\UAS.T:Hsap\MYC embryonic/larval dorsal vessel arm2 embryonic/larval dorsal vessel | precursor arm2 embryonic/larval ganglionic branch arm2 embryonic/larval lateral trunk arm2 arm4 arm8 embryonic/larval salivary gland, with Scer\GAL4Act5C.PP armΔ.Scer\UAS.T:Ivir\HA1 embryonic/larval tracheal system arm4 arm8 embryonic/larval tracheal system | germline clone arm2 embryonic/larval visceral branch, with Scer\GAL4btl.PS armS10.Scer\UAS.T:Hsap\MYC embryonic dorsal epidermis arm1 arm2 embryonic epidermis arm2 arm3 arm4 arm8 embryonic epidermis, with Scer\GAL4da.G32 armΔN.Scer\UAS embryonic epidermis, with Scer\GAL4e22c armS10.Scer\UAS.T:Hsap\MYC embryonic epidermis | dorsal arm2 arm3 embryonic epidermis | dorsal, with Scer\GAL4arm.PS armS10.Scer\UAS.T:Hsap\MYC embryonic epidermis | dorsal, with Scer\GAL4arm.T:Hsim\VP16 armS10.Scer\UAS.T:Hsap\MYC embryonic epidermis | dorsal, with Scer\GAL4ptc-559.1 armS10.Scer\UAS.T:Hsap\MYC embryonic epidermis | germline clone arm3 embryonic epidermis | segment polarity expression pattern arm3 embryonic epidermis | ventral arm3 embryonic gnathal segment arm1 embryonic head arm#2 arm1 arm13-17 arm2 arm25B arm3 arm6 embryonic head, with arm1 armS14.T:Hsap\MYC embryonic head, with armS14.T:Hsap\MYC arm1 embryonic head, with Scer\GAL4e22c armScer\UAS.T:Hsap\MYC,T:Xlae\Ncad embryonic leading edge cell arm3 embryonic Malpighian tubule | germline clone arm2 embryonic neuroblast arm3 embryonic optic lobe primordium, with arm1 armS14.T:Hsap\MYC embryonic optic lobe primordium, with armS14.T:Hsap\MYC arm1 embryonic segment arm1 arm2 embryonic segment | cell autonomous | somatic clone arm1 embryonic ventral epidermis, with arm1 armS14.T:Hsap\MYC embryonic ventral epidermis, with armS14.T:Hsap\MYC arm1 embryonic ventral nervous system arm4 epithelial cell arm3 extended germ band embryo, with Scer\GAL4e22c armScer\UAS.T:Hsap\MYC,T:Xlae\Ncad eye armS44Y.GMR armS56F.GMR eye, with Scer\GAL4ey.PH armScer\UAS.cCa eye, with Scer\GAL4GMR.PF armS10.Scer\UAS.T:Hsap\MYC armS56F.GMR armScer\UAS.cSa armScer\UAS.cWa eye, with Scer\GAL4GMR.PY armΔ.Scer\UAS.T:Ivir\HA1 eye, with Scer\GAL4hs.2sev armS10.Scer\UAS.T:Hsap\MYC eye | cell non-autonomous | somatic clone armact.hs.2sev eye | cell non-autonomous | somatic clone, with Scer\GAL4GMR.PF armScer\UAS.cTa eye | somatic clone arm2 eye | somatic clone, with Scer\GAL4Act5C.PI armΔ.Scer\UAS.T:Ivir\HA1 eye disc, with Scer\GAL4Act5C.PP armΔ.Scer\UAS.T:Ivir\HA1 eye disc, with Scer\GAL4ey.PH armScer\UAS.cCa eye disc, with Scer\GAL4GMR.PY armΔ.Scer\UAS.T:Ivir\HA1 eye photoreceptor cell, with Scer\GAL4arm.PS armact.Scer\UAS eye photoreceptor cell, with Scer\GAL4elav-C155 armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 armScer\UAS.Exel armScer\UAS.cSa eye photoreceptor cell, with Scer\GAL4GMR.long armS10.Scer\UAS.T:Hsap\MYC eye photoreceptor cell, with Scer\GAL4hs.2sev armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC eye photoreceptor cell | somatic clone armact.hs.2sev eye photoreceptor cell | somatic clone | third instar larval stage arm3 female germline stem cell | somatic clone arm4 follicle cell arm3 follicle cell | somatic clone arm1 arm3 arm4 follicle stem cell | somatic clone arm2 arm3 arm4 arm8 genital disc | somatic clone, with Scer\GAL4Act5C.PP armΔ.Scer\UAS.T:Ivir\HA1 germline cell arm4 gonad arm1 heart primordium armdsRNA.cKa armdsRNA.si.cKa imaginal disc | larval stage | somatic clone arm1 arm3 arm4 interfollicle cell | supernumerary | heat sensitive, with Scer\GAL4hs.PB armS10.Scer\UAS.T:Hsap\MYC interommatidial bristle, with Scer\GAL4GMR.PF armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cWa interommatidial bristle, with Scer\GAL4hs.2sev armS10.Scer\UAS.T:Hsap\MYC interommatidial bristle | ectopic | somatic clone arm25B longitudinal connective arm8 lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4dome-PG14 armΔN.Scer\UAS armS10.Scer\UAS.T:Hsap\MYC macrochaeta | ectopic, with Scer\GAL4bbg-C96 armact.Scer\UAS mesothoracic tergum, with Scer\GAL4pnr-MD237 armGD1372 midgut constriction 1, with Scer\GAL4how-24B armS10.Scer\UAS.T:Hsap\MYC midgut constriction 2 arm2 arm3 midgut constriction 2, with Scer\GAL4how-24B armS10.Scer\UAS.T:Hsap\MYC morphogenetic furrow, with Scer\GAL4dpp.blk1 armS10.Scer\UAS.T:Hsap\MYC MP1 neuron arm4 nucleus, with Scer\GAL4Act5C.PP armΔ.Scer\UAS.T:Ivir\HA1 nucleus | embryonic stage 4 | germline clone arm3 nurse cell arm3 nurse cell & actin filament arm4 nurse cell & nucleus arm4 nurse cell & nucleus | germ-line clone arm1 nurse cell | germline clone arm1 arm4 nurse cell ring canal arm4 nurse cell ring canal | germline clone arm1 ommatidium, with Scer\GAL4arm.PS armact.Scer\UAS ommatidium, with Scer\GAL4elav-C155 armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 ommatidium, with Scer\GAL4GMR.PF armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cWa ommatidium, with Scer\GAL4hs.2sev armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC ommatidium | somatic clone arm2 armact.hs.2sev ommatidium | somatic clone, with Scer\GAL4Act5C.PI armΔ.Scer\UAS.T:Ivir\HA1 oocyte arm1 oocyte & actin filament arm4 oocyte | germline clone arm1 arm4 oocyte | somatic clone arm4 ovariole arm1 ovariole | germline clone arm1 ovary | germline clone arm1 pCC neuron arm4 photoreceptor cell, with Scer\GAL4Act5C.PP armΔ.Scer\UAS.T:Ivir\HA1 pigment cell | somatic clone armact.hs.2sev pleural membrane, with Scer\GAL4GF1 armΔ.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC pleurum, with Scer\GAL4dpp.blk1 armS10.Scer\UAS.T:Hsap\MYC pleurum | ectopic | somatic clone arm2 posterior spiracle primordium arm4 presumptive embryonic/larval central nervous system arm8 retina | somatic clone armact.hs.2sev RP2 neuron arm4 arm8 salivary gland armL51 segment arm5 arm8 armS11.T:Hsap\MYC armS12.T:Hsap\MYC armS15.T:Hsap\MYC armS5.T:Hsap\MYC armS6.T:Hsap\MYC sensory mother cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC spindle | cleavage stage | maternal effect arm3 spiracular branch 10 arm4 spot adherens junction arm3 sternite, with Scer\GAL4GF1 armΔ.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC stomodeal invagination arm2 syncytial blastoderm embryo | germline clone arm3 T1 beard, with Scer\GAL469B armS10.Scer\UAS.T:Hsap\MYC tarsal segment, with Scer\GAL4dpp.blk1 armGS1141 tracheal branch primordium arm4 arm8 tracheal metamere arm2 ventral furrow arm3 ventral furrow | maternal effect arm043A01 ventral row arm1 arm8 armBCD7 vMP2 neuron arm4 wing arm8 armBCD7 wing, with Scer\GAL430A armS10.Scer\UAS.T:Hsap\MYC armS2.Scer\UAS.T:Hsap\MYC wing, with Scer\GAL471B armΔ.Scer\UAS.T:Ivir\HA1 wing, with Scer\GAL4bbg-C96 armS10.Scer\UAS.T:Hsap\MYC armact.Scer\UAS wing, with Scer\GAL4Bx-MS1096 armΔC.Scer\UAS armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cWa wing, with Scer\GAL4HV1 armΔ.Scer\UAS.T:Ivir\HA1 wing, with Scer\GAL4nub-AC-62, Scer\GAL80ts.αTub84B armS10.Scer\UAS.T:Hsap\MYC wing & macrochaeta, with Scer\GAL4C-765 armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 wing & macrochaeta | ectopic, with Scer\GAL4C-765 armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 wing | posterior, with Scer\GAL4en-e16E armScer\UAS.cWa wing disc, with Scer\GAL4bbg-C96 armΔN.Scer\UAS wing disc, with Scer\GAL4Dll-md23 armS10.Scer\UAS.T:Hsap\MYC wing disc, with Scer\GAL4dpp.blk1 armΔN.Scer\UAS armS10.Scer\UAS.T:Hsap\MYC wing disc, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC wing disc, with Scer\GAL4T80 armΔN.Scer\UAS wing disc | anterior compartment, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC wing disc | somatic clone, with Scer\GAL4αTub84B.PZ armΔ.Scer\UAS.T:Ivir\HA1 wing hair, with Scer\GAL4nub-AC-62, Scer\GAL80ts.αTub84B armS10.Scer\UAS.T:Hsap\MYC wing hinge, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC wing hinge primordium | ectopic | larval stage | somatic clone, with Scer\GAL4αTub84B.PL armΔα.Scer\UAS wing margin bristle, with Scer\GAL4Bx-MS1096 armΔC.Scer\UAS armS10.Scer\UAS.T:Hsap\MYC wing margin bristle | ectopic, with Scer\GAL4405 armS10.Scer\UAS.T:Hsap\MYC wing margin bristle | ectopic, with Scer\GAL4bbg-C96 armS10.Scer\UAS.T:Hsap\MYC armScer\UAS.cWa wing margin bristle | ectopic, with Scer\GAL4Bx-MS1096 armΔC.Scer\UAS armScer\UAS.cWa wing margin bristle | ectopic, with Scer\GAL4en-e16E armScer\UAS.cSa armScer\UAS.cWa wing margin bristle | ectopic, with Scer\GAL4sd-SG29.1 armS10.Scer\UAS.T:Hsap\MYC wing margin bristle | ectopic, with Scer\GAL4vg.PM armΔ.Scer\UAS.T:Ivir\HA1 armS10.Scer\UAS.T:Hsap\MYC wing sensillum | ectopic, with Scer\GAL4en-e16E armScer\UAS.cWa wing vein, with Scer\GAL471B armΔ.Scer\UAS.T:Ivir\HA1 wing vein, with Scer\GAL4HV1 armΔ.Scer\UAS.T:Ivir\HA1 wing vein | ectopic, with Scer\GAL4bs-1348 armS10.Scer\UAS.T:Hsap\MYC wing vein | ectopic, with Scer\GAL4Bx-MS1096 armΔC.Scer\UAS armScer\UAS.cWa wing vein | ectopic, with Scer\GAL4en-e16E armScer\UAS.cWa zonula adherens arm3
Classical Alleles ( 37 )
For All Classical Alleles Show
Allele of arm Class Mutagen Stocks Known lesion arm1 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes arm4 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes arme04595 piggyBac transposase 2 -- armG0268a P-element activity 2 -- arm2 amorphic allele - genetic evidence, loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes arm3 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes arm5-HA-1184 1 -- arm8 loss of function allele, hypomorphic allele - genetic evidence PM hybrid dysgenesis 1 Yes armEY15565 P-element activity 1 -- armG0192 P-element activity 1 -- armGS1141 Delta2-3 1 Yes arm2a9 amorphic allele - genetic evidence X ray 0 Yes arm#2 ethyl methanesulfonate 0 Yes arm043A01 ethyl methanesulfonate 0 Yes arm13-17 X ray 0 Yes arm17-114 0 -- arm25B loss of function allele, hypomorphic allele - genetic evidence PM hybrid dysgenesis 0 Yes arm5 PM hybrid dysgenesis 0 Yes arm6 PM hybrid dysgenesis 0 Yes armBCD7 P-element activity 0 -- armCPTI001198 piggyBac transposase 0 Yes armEH243 ethyl methanesulfonate 0 -- armEY12037 P-element activity 0 -- armF1α loss of function allele, hypomorphic allele - genetic evidence 0 Yes armG0234 P-element activity 0 -- armG0410 P-element activity 0 -- armI 0 -- armK2 0 -- armL51 ethyl methanesulfonate 0 -- armLM134 loss of function allele 0 Yes armPG120 Delta2-3 0 -- armPG98 Delta2-3 0 -- armPL27 Delta2-3 0 -- armS9 ethyl methanesulfonate 0 -- armT52A.S56A.Act5C 0 Yes armunspecified 0 -- armweep 0 Yes
Alleles Carried on Transgenic Constructs ( 147 )
For All Alleles Carried on Transgenic Constructs Show
Allele of arm Class Mutagen Stocks Known lesion armNdel.vg.MQ gain of function allele in vitro construct - regulatory fusion in vitro construct - deletion 3 Yes armS56F.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 3 Yes arm+mOa.T:Avic\GFP in vitro construct - coding region fusion 2 Yes armS10.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 2 Yes armS2.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 2 Yes armScer\UAS.Exel in vitro construct - regulatory fusion 2 Yes armGD1372 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes armGMR.Exel in vitro construct - regulatory fusion 1 Yes armHMS01414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes armJF01251 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes armJF01252 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes armKK102545 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes armT52A.GMR gain of function allele in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes arm+mOa in vitro construct - minigene 0 Yes arm+mWa in vitro construct - regulatory fusion 0 Yes arm+t10.5 in vitro construct - genomic fragment 0 Yes arm043.Scer\UAS FLPase 0 Yes arm1-429.T:Scer\GAL4 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes arm429-843.T:Scer\GAL4 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes armAAA.S10.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes armact.hs.2sev FLPase 0 Yes armact.Scer\FRT.hs.2sev in vitro construct - regulatory fusion 0 Yes armact.Scer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes armact.Scer\UAS FLPase 0 Yes armAct5C.PD in vitro construct - regulatory fusion 0 Yes armcBa in vitro construct 0 Yes armcMa.T:Avic\GFP in vitro construct - coding region fusion 0 Yes armD164A.αTub84B.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes armD88A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes armdsRNA.cBa in vitro construct - RNAi 0 Yes armdsRNA.cKa in vitro construct - RNAi 0 Yes armdsRNA.cLa in vitro construct - RNAi 0 Yes armdsRNA.cMa in vitro construct - RNAi 0 -- armdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes armdsRNA.si.cKa in vitro construct - RNAi 0 Yes armE163A.αTub84B.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes armED-QN.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armhs.2sev in vitro construct - regulatory fusion 0 Yes armhs.Sev.T:Ivir\HA1,T:Scer\GAL4,T:Hsim\VP16 FLPase 0 Yes armhs.T:Scer\GAL4,T:en-Rep FLPase 0 Yes armhs.T:Scer\GAL4,T:Hsim\VP16 FLPase 0 -- armhs.T:Scer\GAL4 FLPase 0 Yes armK435E.αTub84B.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes armM+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 FLPase 0 Yes armM-N+.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 FLPase 0 Yes armM-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armm.Δ.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armMtnA.PP in vitro construct - regulatory fusion 0 Yes armMtnA.PY in vitro construct - regulatory fusion 0 Yes armMtnA.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes armNIG.11579R in vitro construct - regulatory fusion in vitro construct - RNAi 0 -- armNR.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armR.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armR.Scer\UAS in vitro construct - regulatory fusion 0 Yes armS10.D164A.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armS10.K435E.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armS10.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armS10.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS11.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS12.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS14.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS15.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS2.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes armS4.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes armS44Y.GMR in vitro construct - regulatory fusion 0 Yes armS5.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armS56A.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armS56A.Scer\UAS.T:Zzzz\His6.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes armS56F.GMR in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes armS58A.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armS6.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes armS8 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement ethyl methanesulfonate 0 Yes armScer\FRT.Rnor\CD2.043.Scer\UAS in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.hs.Sev.T:Ivir\HA1,T:Scer\GAL4,T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.hs.T:Scer\GAL4,T:en-Rep in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.hs.T:Scer\GAL4,T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.hs.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes armScer\FRT.Rnor\CD2.M+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.M-N+.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.m.Δ.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.Scer\UAS.T:Ivir\HA1,T:Myr1,T:SV40\nls2 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Scer\UAS in vitro construct - regulatory fusion 0 Yes armScer\FRT.Rnor\CD2.Sev.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.XM19.Scer\UAS in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.XP33.Scer\UAS in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.Δ.M+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.Δ.M-N+.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.Δ.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis 0 Yes armScer\FRT.Rnor\CD2.Δ.Scer\UAS.T:Ivir\HA1,T:Myr1,T:SV40\nls2 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Δ.Scer\UAS in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.Δ.Sev.M-N+.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Δ.Sev.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Δ.XM19.Scer\UAS in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.Δ.Δ.M+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.Δ.Δ.M-N-.Scer\UAS.T:Ivir\HA1,T:Hsim\VP16 in vitro construct - coding region fusion 0 Yes armScer\FRT.Rnor\CD2.Δ.Δ.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes armScer\FRT.Rnor\CD2.Δ.Δ.Sev.M-N-.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes armScer\UAS.cCa FLPase 0 Yes armScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes armScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes armScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes armScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes armScer\UAS.T:Hsap\MYC,T:Ocun\nes in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armScer\UAS.T:Hsap\MYC,T:SV40\nls2 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armScer\UAS.T:Hsap\MYC,T:Xlae\Ncad in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armScer\UAS.T:Ivir\HA1,T:Myr1,T:SV40\nls2 FLPase 0 Yes armScer\UAS.T:Ivir\HA1 FLPase 0 Yes armScer\UAS.T:sev-TM in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armScer\UAS.wt in vitro construct - regulatory fusion 0 Yes armSev.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armST-A.MtnA.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes armT:Avic\GFP in vitro construct - coding region fusion 0 Yes armT:Hsap\MYC,T:Hsap\CAAX in vitro construct - coding region fusion 0 Yes armT:Scer\GAL4 in vitro construct - coding region fusion 0 Yes armXM19.Scer\UAS FLPase 0 Yes armXP33.Scer\UAS FLPase 0 Yes armαTub84B.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes armΔ.D164A.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armΔ.K435E.Scer\UAS.T:Hsap\MYC in vitro construct - site directed mutagenesis 0 Yes armΔ.M+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 FLPase 0 Yes armΔ.M-N+.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 FLPase 0 Yes armΔ.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armΔ.Scer\FRT-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armΔ.Scer\FRT.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes armΔ.Scer\UAS.T:Hsap\MYC in vitro construct - coding region fusion 0 Yes armΔ.Scer\UAS.T:Ivir\HA1,T:Myr1,T:SV40\nls2 FLPase 0 Yes armΔ.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes armΔ.Scer\UAS FLPase 0 Yes armΔ.Sev.M-N+.Scer\UAS.T:Ivir\HA1,T:SV40\nls2 FLPase 0 Yes armΔ.Sev.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armΔ.XM19.Scer\UAS FLPase 0 Yes armΔ.Δ.M+N-.Scer\UAS.T:Ivir\HA1,T:Myr1 FLPase 0 Yes armΔ.Δ.M-N-.Scer\UAS.T:Ivir\HA1,T:Hsim\VP16 FLPase 0 Yes armΔ.Δ.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armΔ.Δ.Sev.M-N-.Scer\UAS.T:Ivir\HA1 FLPase 0 Yes armΔ114.MtnA.T:Hsap\MYC in vitro construct - coding region fusion in vitro construct - deletion 0 Yes armΔC.Scer\UAS in vitro construct - regulatory fusion 0 Yes armΔN-88.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes armΔN.Act5C in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes armΔN.Scer\UAS in vitro construct - coding region fusion 0 Yes armΔN.T:Hsap\MYC in vitro construct - site directed mutagenesis in vitro construct - deletion 0 Yes armΔN138.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes armΔN58.MtnA.T:Hsap\MYC in vitro construct - deletion 0 Yes armΔα.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Dp(1;3)wvco (Wieschaus et al., 1984) T(1;2)Bld (Wieschaus et al., 1984) T(1;3)scJ4 (Harbecke and Lengyel, 1995)
Not disrupted in	Df(1)A94 (Tearle and Nusslein-Volhard, 1987) Df(1)svr (Wieschaus et al., 1984) Dp(1;Y)y267g19.1 (Wieschaus et al., 1984) Ts(1Rt;2Rt)Bld (Wieschaus et al., 1984)
Duplicated in	Dp(1;3)DC034 (Popodi et al., 2010-) Dp(1;3)DC446 (Popodi et al., 2010-) Dp(1;Y)armYD35 (Kalamegham et al., 2007) Dp(1;Y)y267g19.1 (Tearle and Nusslein-Volhard, 1987, Eberl and Hilliker, 1988, Cox et al., 1996)
Not duplicated in	Dp(1;2;Y)w+ (Eberl and Hilliker, 1988) Dp(1;f)101 (Eberl and Hilliker, 1988) Dp(1;Y)y2sc (Eberl and Hilliker, 1988, Eberl and Hilliker, 1988) Ts(1Lt;2Lt)Bld (Tearle and Nusslein-Volhard, 1987)
Transgenic Constructs & Insertions
Transgenic Constructs
heat-shock construct	Name Expression Data P{2sev-hs-arm.W} NA P{hsp70(FRT.CD2,y+)arm.GAL4.enRep} NA P{hsp70(FRT.CD2,y+)arm.GAL4.VP16} NA P{hsp70(FRT.CD2,y+)arm.GAL4} NA P{hsp70(FRT.CD2,y+)arm.Sev.Flu.GAL4.VP16} NA P{hsp70(-FRT)arm.GAL4.enRep} NA P{hsp70(-FRT)arm.GAL4.VP16} NA P{hsp70(-FRT)arm.GAL4} NA P{hsp70(-FRT)arm.Sev.Flu.GAL4.VP16} NA
reporter construct	Name Expression Data P{11E3:6.2} No P{11E3:15.4} No P{23E12:7.7} No P{123B12:9.0} No P{144A7:12.8} No P{185B11:5.0} No P{185B11:6.6} No P{arm-lacZ.V} No P{arm-lacZ-Brd+GYmut} No P{arm-lacZ-Brdmut123} No P{arm-lacZ-GYmut} No P{arm-lacZ-m8.5xCAACmut} No P{arm-lacZ-m8.K1K2mut} No P{arm-lacZ-m8.K/CAACdel} No P{arm-lacZ-m8.wt} No P{arm-lacZ-SV40t} No P{arm-lacZ-wtBrd} No P{HF11} No P{HF17} No P{HF18} No
UAS construct	Name Expression Data P{GD1372} NA P{GMR-arm.S56F} NA P{KK102545} NA P{Scer(FRT.CD2,y+)arm.Sev.M-N-.Flu} NA P{Scer\UAS(FRT.CD2).arm.Flu} NA P{TRiP.HMS01414} NA P{TRiP.JF01251} NA P{TRiP.JF01252} NA P{UAS(FRT.CD2,y+)arm.043} NA P{UAS(FRT.CD2,y+)arm.C} NA P{UAS(FRT.CD2,y+)arm.Flu} NA P{UAS(FRT.CD2,y+)arm.M+N+.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.M+N+.Flu} NA P{UAS(FRT.CD2,y+)arm.M+N-.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.M+N-.Flu.ΔΔ} NA P{UAS(FRT.CD2,y+)arm.M+N-.Flu} NA P{UAS(FRT.CD2,y+)arm.M-N+.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.M-N+.Flu} NA P{UAS(FRT.CD2,y+)arm.M-N-.Flu.VP16.ΔΔ} NA P{UAS(FRT.CD2,y+)arm.M-N-.Flu.Δ.m} NA P{UAS(FRT.CD2,y+)arm.M-N-.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.M-N-.Flu.ΔΔ} NA P{UAS(FRT.CD2,y+)arm.M-N-.Flu} NA P{UAS(FRT.CD2,y+)arm.Sev.M-N+.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.Sev.M-N-.Flu.Δ} NA P{UAS(FRT.CD2,y+)arm.Sev.M-N-.Flu.ΔΔ} NA P{UAS(FRT.CD2,y+)arm.XM19} NA P{UAS(FRT.CD2,y+)arm.XP33} NA P{UAS(FRT.CD2,y+)arm.Δ.XM19} NA P{UAS(FRT.CD2,y+)arm.Δ} NA P{UAS(FRT.wGMR)arm.act} NA P{UAS(FRT.y+CD2)arm.Δ.flu} NA P{UAS(-FRT)arm.043} NA P{UAS(-FRT)arm.act} NA P{UAS(-FRT)arm.C} NA P{UAS(-FRT)arm.Flu} NA P{UAS(-FRT)arm.M+N+.Flu.Δ} NA P{UAS(-FRT)arm.M+N+.Flu} NA P{UAS(-FRT)arm.M+N-.Flu.Δ} NA P{UAS(-FRT)arm.M+N-.Flu.ΔΔ} NA P{UAS(-FRT)arm.M+N-.Flu} NA P{UAS(-FRT)arm.M-N+.Flu.Δ} NA P{UAS(-FRT)arm.M-N+.Flu} NA P{UAS(-FRT)arm.M-N-.Flu.VP16.ΔΔ} NA P{UAS(-FRT)arm.M-N-.Flu.Δ.m} NA P{UAS(-FRT)arm.M-N-.Flu.Δ} NA P{UAS(-FRT)arm.M-N-.Flu.ΔΔ} NA P{UAS(-FRT)arm.Sev.M-N+.Flu.Δ} NA P{UAS(-FRT)arm.Sev.M-N-.Flu.Δ} NA P{UAS(-FRT)arm.Sev.M-N-.Flu.ΔΔ} NA P{UAS(-FRT)arm.Sev.M-N-.Flu} NA P{UAS(-FRT)arm.XM19} NA P{UAS(-FRT)arm.XP33} NA P{UAS(-FRT)arm.Δ.flu} NA P{UAS(-FRT)arm.Δ.XM19} NA P{UAS(-FRT)arm.Δ} NA P{UAS-arm.D88A} NA P{UAS-arm.D164A.Myc} NA P{UAS-arm.Exel} NA P{UAS-arm.K435E.Myc} NA P{UAS-arm.K} NA P{UAS-arm.NES} NA P{UAS-arm.NLS} NA P{UAS-arm.NR} NA P{UAS-arm.R} NA P{UAS-arm.RMyc} NA P{UAS-arm.S2} NA P{UAS-arm.S10.AAA} NA P{UAS-arm.S10} NA P{UAS-arm.S56A} NA P{UAS-arm.S} NA P{UAS-arm.T} NA P{UAS-arm.TM} NA P{UAS-arm.W} NA P{UAS-arm.wt} NA P{UAS-arm.Δ.D164A} NA P{UAS-arm.Δ.flu} NA P{UAS-arm.Δ.K435E} NA P{UAS-arm.ΔC} NA P{UAS-arm.ΔMYC} NA P{UAS-arm.ΔN-88} NA P{UAS-arm.ΔN} NA P{UAS-arm.Δα} NA P{UAS-sev-arm} NA
characterization construct	Name Expression Data P{arm10.5} NA P{arm.CAAX} NA P{arm.S4} NA P{arm.S5} NA P{arm.S6} NA P{arm.S8} NA P{arm.S10} NA P{arm.S11} NA P{arm.S12} NA P{arm.S14} NA P{arm.S15} NA P{arm} NA P{arm+mWa} NA P{arm-cmyc} NA P{arm-eGFP} NA P{arm-GFP.P} NA P{arm-GFP} NA P{arm-HeT-A\gag::EGFP} NA P{arm-Hsap\JUP.W} NA P{arm-I-element\gag::EGFP} NA P{arm-jockey\gag::EGFP} NA P{arm-Mmus\Catnb.W} NA P{arm-TART-element\gag::EGFP} NA P{arm-TFR-K10} NA P{arm-TFR-olc21} NA P{GFP-arm} NA P{GMR-arm.Exel} NA P{GMR-arm.T52A} NA P{GMR-armS44Y} NA P{GMR-armS56F} NA P{hs.2sev(FRT.wGMR)arm.act} NA P{hs.2sev(-FRT)arm.act} NA P{NIG.11579R} NA P{UAS(FRT.CD2,y+)arm::Pen.m.Δ.M-N-.Flu} NA P{UAS(FRT.CD2,y+)arm::Pen.Δ.M-N-.Flu} NA P{UAS(-FRT)arm::Pen.m.Δ.M-N-.Flu} NA P{UAS(-FRT)arm::Pen.Δ.M-N-.Flu} NA P{UAS-armC-ΔNpan} NA P{vgMQ-arm.Ndel} NA P{ΔN} NA P{αTub-arm.D164A.MYC} NA P{αTub-arm.E163A.MYC} NA P{αTub-arm.K435E.MYC} NA P{αTub-arm.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}armEY12037 NA P{EPgy2}armEY15565 NA P{GSV1}armGS1141 NA P{Mae-UAS.6.11}GG01365GG01365 NA miscellaneous insertions P{}arm5 NA P{}arm6 NA P{}arm8 NA P{}arm25B NA P{arm10.5}BCD7 NA P{RS5}arm5-HA-1184 NA P{Wee-P.un1}armweep NA PBac{681.P.FSVS-1}armCPTI001198 NA PBac{RB}arme04595 NA insertion of enhancer trap P{lacW}armG0192 No P{lacW}armG0234 No P{lacW}armG0268a No P{lacW}armG0410 No P{lacW}armPL27 No insertion of enhancer trap binary system P{GawB}armPG98 No P{GawB}armPG120 No
Gene Ontology: Function, Process & Cellular Component ( 48 unique terms )
Terms Based on Experimental Evidence ( 37 terms )
Molecular Function
CV term Evidence References
kinase binding inferred from physical interaction with hipk (Lee et al., 2009) protein binding inferred from physical interaction with Apc2 (Webb et al., 2009, McCartney et al., 1999) inferred from physical interaction with Axn (Kremer et al., 2010) inferred from physical interaction with Mer (McCartney et al., 1999) inferred from physical interaction with ssp (Taniue et al., 2010) inferred from physical interaction with UniProtKB:P22265 (assigned by UniProtKB) (Gallet et al., 1998) contributes_to RNA polymerase II transcription coactivator activity inferred from physical interaction with lgs (Thompson, 2004) inferred from physical interaction with pygo (Thompson, 2004) transcription coactivator activity inferred from direct assay (Thompson, 2004)
Biological Process
CV term Evidence References
branch fusion, open tracheal system inferred from mutant phenotype (Lee et al., 2003, Chihara and Hayashi, 2000) branching morphogenesis of a tube inferred from mutant phenotype (Chihara and Hayashi, 2000) cell adhesion inferred from mutant phenotype (Kiger et al., 2003, Martin et al., 2010) cell-cell adhesion inferred from mutant phenotype (Harris and Peifer, 2004, Sokac and Wieschaus, 2008) cell fate determination inferred from mutant phenotype (Jones et al., 2010) cell morphogenesis inferred from mutant phenotype (Harris and Peifer, 2004) chitin-based larval cuticle pattern formation inferred from mutant phenotype (Kaplan et al., 2009) compound eye morphogenesis inferred from mutant phenotype (Tomlinson, 2003) compound eye retinal cell programmed cell death inferred from mutant phenotype (Ahmed et al., 1998) cuticle pattern formation inferred from mutant phenotype (Hoffmans et al., 2005) delamination inferred from mutant phenotype (Kiger et al., 2007) dorsal closure inferred from mutant phenotype (Myster et al., 2003) epithelial cell type specification, open tracheal system inferred from mutant phenotype (Chihara and Hayashi, 2000) heart formation inferred from mutant phenotype (Park et al., 1996) imaginal disc-derived wing expansion inferred from mutant phenotype (Kiger et al., 2007) negative regulation of heart induction by canonical Wnt receptor signaling pathway inferred from mutant phenotype (Park et al., 1996) nervous system development inferred from mutant phenotype (Koizumi et al., 2007) neuroblast development inferred from mutant phenotype (Harris and Peifer, 2004) oogenesis inferred from mutant phenotype (Song and Xie, 2003) photoreceptor cell differentiation inferred from mutant phenotype (Beronja et al., 2005) positive regulation of transcription, DNA-dependent inferred from mutant phenotype (Dichtel-Danjoy et al., 2009) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Park et al., 2003, Thompson, 2004) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) somatic stem cell maintenance inferred from mutant phenotype (Song and Xie, 2003) ventral furrow formation inferred from mutant phenotype (Harris and Peifer, 2004) wing disc morphogenesis inferred from mutant phenotype (Kiger et al., 2007) Wnt receptor signaling pathway inferred from mutant phenotype (Thompson, 2004, Peifer et al., 1994) zonula adherens assembly inferred from mutant phenotype (Harris and Peifer, 2004)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Hong et al., 2001, Peifer et al., 1994) apical plasma membrane inferred from direct assay (Ahmed et al., 1998) cytoplasm inferred from direct assay (Peifer et al., 1994, Thompson, 2004) nucleus inferred from direct assay (Thompson, 2004, Park et al., 2003) zonula adherens inferred from direct assay (Peifer, 1993)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
alpha-catenin binding non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) cytoskeletal protein binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
cytoskeletal anchoring at plasma membrane inferred from sequence or structural similarity (Hynes and Zhao, 2000) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) neuroblast fate determination non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) oocyte localization involved in germarium-derived egg chamber formation traceable author statement (Deng and Lin, 2001) ovarian follicle cell development traceable author statement (Dobens and Raftery, 2000) Wnt receptor signaling pathway inferred from sequence or structural similarity with mouse Catnb (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Cellular Component
CV term Evidence References
adherens junction non-traceable author statement (Swiss-Prot Project Members, 1990.11.1, Humbert et al., 2003) apicolateral plasma membrane traceable author statement (Tepass et al., 2001) catenin complex inferred from sequence or structural similarity (Hynes and Zhao, 2000) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) membrane non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) spot adherens junction non-traceable author statement (Wedlich, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions arm allele Gene References arm1 eRF1 (Chao et al., 2003) fz (Zhang and Carthew, 1998) mam (Helms et al., 1999) arm2 ci (Angelats et al., 2002) Dad (Ribeiro et al., 2004) eRF1 (Chao et al., 2003) nej (Waltzer and Bienz, 1998) pan (Cavallo et al., 1998) salm (Llimargas, 2000) sgg (Cox et al., 2000, Tolwinski and Wieschaus, 2004) shg (Waltzer and Bienz, 1998) tkv (Llimargas, 2000) arm3 Abl (Loureiro and Peifer, 1998) bsk (McEwen et al., 2000) ci (Cavallo et al., 1998) dpp (McEwen et al., 2000) gro (Cavallo et al., 1998) hep (McEwen et al., 2000) pan (Cavallo et al., 1998, Cox et al., 2000) Psn (Cox et al., 2000) puc (McEwen et al., 2000, Cox et al., 2000) shg (Loureiro and Peifer, 1998) spi (Cox et al., 2000) Tak1 (McEwen et al., 2000) tkv (McEwen et al., 2000) W (Cox et al., 2000) arm4 Abl (Loureiro and Peifer, 1998) Apc (Ahmed et al., 1998) CycE (Brumby et al., 2004) ena (Grevengoed et al., 2001) gro (Cavallo et al., 1998) nkd (Zeng et al., 2000) p120ctn (Myster et al., 2003) pan (Cavallo et al., 1998) pan::pygo (Thompson, 2004) Psn (Cox et al., 2000) W (Cox et al., 2000) arm8 ena (Grevengoed et al., 2001) sgg (Tolwinski et al., 2003) armact.Scer\UAS dally (Lin and Perrimon, 1999) armF1α sgg (Tolwinski et al., 2003) armS2.Scer\UAS.T:Hsap\MYC shg (Kataoka et al., 2001) armS8 sgg (Tolwinski and Wieschaus, 2004) wg (Brunner et al., 1997) armS9 wg (Brunner et al., 1997) armS10.Scer\UAS.T:Hsap\MYC ci (Angelats et al., 2002) dlp (Baeg et al., 2001) hep (Kaltschmidt et al., 2002) mam (Helms et al., 1999) ovo (Payre et al., 1999) tkv (Llimargas, 2000) tws (Bajpai et al., 2004) wg (San Martin and Bate, 2001) armS12.T:Hsap\MYC pan::pygo (Thompson, 2004) armS56F.GMR brm (Barker et al., 2001) mor (Barker et al., 2001) pan (Barker et al., 2001) pygo (Parker et al., 2002, Thompson et al., 2002) spen (Lin et al., 2003) armScer\UAS.cSa pont (Bauer et al., 2000) rept (Bauer et al., 2000) armScer\UAS.cWa aos (Greaves et al., 1999) cdc2 (Greaves et al., 1999) crb (Greaves et al., 1999) CycA (Greaves et al., 1999) dlg1 (Greaves et al., 1999) ds (Greaves et al., 1999) dsh (Greaves et al., 1999) Egfr (Greaves et al., 1999) EP1421 (Greaves et al., 1999) Fas3 (Greaves et al., 1999) ft (Greaves et al., 1999) l(2)dC9 (Greaves et al., 1999) l(3)09291 (Greaves et al., 1999) lilli (Greaves et al., 1999) nkd (Greaves et al., 1999) rho (Greaves et al., 1999) sdt (Greaves et al., 1999) sgg (Greaves et al., 1999) shg (Greaves et al., 1999) stg (Greaves et al., 1999) tws (Greaves et al., 1999) wg (Greaves et al., 1999) armΔ.Scer\UAS.T:Ivir\HA1 nmo (Zeng and Verheyen, 2004) unspecified Apc2 (Takacs et al., 2008) CtBP (Fang et al., 2006) L (Singh et al., 2006) nkd (Rousset et al., 2001) pan (Brunner et al., 1997) pygo (Cadigan, 2002.1.24, Townsley et al., 2004) shg (Mirkovic and Mlodzik, 2006, Grevengoed et al., 2001) Src42A (Takahashi et al., 2005) tsh (Angelats et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57697 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000117 DroID - A comprehensive database of gene and protein interactions. • FBgn0000117 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31151
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19474 Dere\GG12670 Dgri\GH17847 Dmoj\GI21760 Dsec\GM18941 Dsim\GD16405 Dvir\GJ19138 Dwil\GK16376 Dyak\GE16998
Curated drosophilid orthologs	Drep\arm
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002887-PA Aedes aegypti (mosquito) AGAP001043-PA Anopheles gambiae (mosquito) XP_391947.2 Apis mellifera (honey bee) XP_001943912.1 Acyrthosiphon pisum (pea aphid) 124698 Branchiostoma floridae (lancelet) XP_001898435.1 Brugia malayi (roundworm nematode) BGIBMGA006959-PA Bombyx mori (silk worm) ENSBTAP00000021838 Bos taurus (bovine) CN07057 Caenorhabditis brenneri (small nematode) CBP19704 Caenorhabditis briggsae (nematode) CE19974 Caenorhabditis elegans (worm) ENSCAFP00000032261 Canis familiaris (dog) ENSCINP00000014417 Ciona intestinalis (sea squirt) JA02369 Caenorhabditis japonica (nematode) CPIJ006700 Culex pipens (mosquito) ENSCPOP00000002653 Cavia porcellus (guinea pig) RP05688 Caenorhabditis remanei (nematode) ENSCSAVP00000006256 Ciona savignyi (sedentary tunicate) 157160 Capitella spl (polychaete worm) 290530 Daphnia pulex (daphnia) ENSDARP00000032935 Danio rerio (zebra fish) ENSECAP00000005466 Equus caballus (horse) ENSGACP00000007992 Gymnopilus aculeatus (mushroom) ENSGALP00000019402 Gallus gallus (chicken) 189420 Hypsipyla robusta (cedar shoot borer) ENSP00000385604 Homo sapiens (human) ISCW023688-PA Ixodes scapularis (deer tick) 205205 Lottia gigantea (owl limpet) ENSMODP00000014004 Monodelphis domestica (gray opossum) ENSMMUP00000019198 Macaca mulatta (rhesus monkey) ENSMUSP00000007130 Mus musculus (house mouse) XP_001603109.1 Nasonia vitripennis (wasp) ENSOANP00000010865 Ornithorynchus anatinus (platypus) ENSORLP00000007357 Oryzias latipes (japanese killifish) PHUM003629-PA Pediculus humanus (human body louse) PHUM003645-PA Pediculus humanus (human body louse) PP22631 Pristionchus pacificus (nematode) ENSPPYP00000015644 Pongo pygmaeus (orangutan) 139436 Phytophthora sojae (root rot pathogen) ENSPTRP00000058940 Pan troglodytes (chimpanzee) ENSRNOP00000026016 Rattus norvegicus (norway rat) Smp_023550 Schistosoma mansoni (trematode parasite) XP_001175634.1 Strongylocentrotus purpuratus (purple sea urchin) 22780 Trichoplax adhaerens (metazoa) XP_971985.1 Tribolium castaneum (red flour beetle) Tc00.1047053511283.160 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022288 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008263 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000030302 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15051 PB10148 NV16988 LH21342 ISCW023688 FBgn0234484 FBgn0218378 FBgn0206283 FBgn0188022 FBgn0173844 JGI_V11_290530 FBgn0248971 FBgn0248967 FBgn0144490 FBgn0125316 FBgn0104958 FBgn0096481 CPIJ006700 BGIBMGA006959 ACYPI007086 ACYPI003226 GB15531 GB12463 ARM_ANOGA ARM_AEDAE PHUM000560 PHUM000580 PHUM280840 GLEAN_12389 GLEAN_12388
Stocks & Reagents
Stocks Listed in FlyBase ( 36 )
Bloomington	8555 w*; P{arm-GFP.P}83 8556 w*; P{arm-GFP.P}57 3378 y1 arm1/FM7c 8554 arm2 P{FRT(whs)}101/FM7a 8557 arm8 P{FRT(whs)}101/FM7a 8558 arm3 P{FRT(whs)}101/FM7a
Harvard	- PBac{RB}arme04595
Kyoto	107022 y1 arm1/FM7c 125127 w1118 P{RS5}arm5-HA-1184 107877 P{UAS-arm.S10}C, y1 w1118
VDRC	v107344 P{KK102545}VIE-260B v7767 w1118; P{GD1372}v7767
	More stocks available...
Genomic Clones ( 2 )
	BACR05N09 BACR33I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 525 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23131
Other clones	DPiM_LD23131
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03585 AT12415 AT23559 GH10790 GH11319 GH11990 GH15440 GH19474 GH20373 GH21029 GH23276 GH27180 GM02821 GM02823 GM03202 GM08352 GM08481 GM09628 GM17885 GM18528 GM22441 HL01329 LD02296 LD03210 LD04416 LD04812 LD07327 LD08229 LD12285 LD13327 LD13389 LD15325 LD16393 LD21693 LD22461 LD23348 LD23407 LD23753 LD25141 LD26144 LD26747 LD26986 LD27826 LD30392 LD30444 LD31942 LD32595 LD33279 LD33681 LD35115 LD35789 LD36017 LD36130 LD37225 LD37766 LD38314 LD40416 LD40815 LD41393 LD41432 LD42023 LD42343 LD42432 LD43980 LD44576 LD44756 LD44827 LD46377 LP03375 LP05418 LP15238 RE01307 RE01417 RE01763 RE01805 RE02191 RE03666 RE05202 RE05380 RE07228 RE08566 RE08837 RE13895 RE14020 RE15054 RE15733 RE15913 RE17602 RE17913 RE19677 RE20957 RE22937 RE26724 RE28032 RE28507 RE29486 RE31466 RE32976 RE34408 RE38204 RE40702 RE46015 RE47167 RE52132 RE57509 RE58363 RE60487 RE69059 RE70370 RH22424 RH27881 RH45094 SD02771 SD04744 SD05227 SD05228 SD06740 SD07546 SD07688 SD08092 SD08126 SD08273 SD09288 SD09531 SD09577 SD09736 SD10350 SD10372 SD10465 SD10601 SD14551 SD15708 SD16407 SD17862 SD19324 SD19484 SD20457 SD20642 SD21012 SD21163 SD22047 SD22333 SD22681 SD22856 SD24039 SD26220 SD27270
Other clones	15922 19438 58227 64858 65021 66804 73746 75528 77814 99317 99910 101250 103053 103411 104166 145276 153411 159658 162958 166235 172455 177722 179594 190559 190774 191150 214221.6 275096 562222 AT01762 CK01.5D.G7 CK01.31C.F3 CK01.59D.G4 CK01.101C.H12 CK01.130C.D3 Dmel_dig_011513_0702_2800 Dmel_dig_014503_0589_1905 Dmel_neb_014871_0947_2392 EC051232 EC051237 EC053734 EC055319 EK040233 EK048358 EK085748 EK100111 EK126256 EK170805 EK175060 EK180635 EK191442 EK194923 EK207437 EK211213 EK222155 EK222260 EK224023 EK224647 EK243260 EK257654 EK267264 EK273231 EK284446 EK292822 EK293034 EK293640 EN13933 EP06819 EP08119 EP12238 FGM206C02 GH01543 GH02441 GH04286 GH04357 GH06114 GH10219 GH12536 GH12678 GH17222 GH20929 GH21077 GH22380 GH24685 GH24790 GH25966 HL04236 IP03876 IP11162 IP12418 IP12518 IP12718 IP14010 IP14210 LD01261 LD02755 LD02852 LD04448 LD05185 LD05434 LD09303 LD09489 LD10006 LD10209 LD11471 LD11892 LD12901 LD13102 LD13225 LD13840 LD13902 LD14886 LD16017 LD16335 LD16575 LD21205 LD21259 LD21578 LD22163 LD22196 LD22930 LD23213 LD23910 LD24003 LD25210 LD26344 LD26453 LD28323 LD28417 LD28990 LD29837 LD30347 LD30646 LD30814 LD31420 LD32349 LD33154 LD33212 LD33342 LD34329 LD35466 LD36004 LD36561 LD37046 LD37159 LD37806 LD38158 LD38409 LD38767 LD38775 LD39236 LD40395 LD40410 LD40878 LD41350 LD41992 LD42263 LD43663 LD43809 LD43841 LD44406 LD45281 LD45555 LD47224 LP01467 LP07334 LP08307 LP08961 LP12867 LP14513 LP17782 LP21125 LP23562 RC0-DP0003-140700-011-F03 RC0-DP0003-150700-012-H11 RC0-DP0003-150700-022-B08 RC0-DP0003-150700-022-B11 RC0-DP0003-150700-022-C05 RC0-DP0003-150700-022-D11 RC0-DP0003-150700-022-E04 RC0-DP0003-150700-022-F01 RC0-DP0003-150700-022-F02 RC0-DP0003-150700-022-F11 RC0-DP0004-150700-011-C05 RC0-DP0004-150700-011-C08 RC0-DP0004-150700-011-D10 RC0-DP0004-150700-011-F08 RC0-DP0004-150700-011-G07 RC0-DP0004-150700-011-H12 RE01855 RE02713 RE03832 RE04111 RE05728 RE05752 RE06218 RE07136 RE08549 RE08587 RE08851 RE09144 RE10068 RE10474 RE10642 RE10989 RE11652 RE11656 RE13933 RE15145 RE16386 RE16757 RE16839 RE17746 RE18306 RE18456 RE20296 RE23141 RE25433 RE26084 RE26378 RE26920 RE26954 RE28075 RE28127 RE28249 RE28627 RE29174 RE30216 RE30259 RE30713 RE30858 RE30890 RE31001 RE31054 RE31114 RE32109 RE32611 RE32694 RE34431 RE35088 RE37051 RE37432 RE38943 RE39414 RE40186 RE40417 RE41211 RE42281 RE43578 RE44035 RE47823 RE48135 RE48957 RE50135 RE50857 RE51711 RE51979 RE54670 RE55643 RE57878 RE59102 RE59348 RE59349 RE61342 RE62342 RE62942 RE64491 RE65216 RE67196 RE67290 RE67838 RE70122 RE71149 RE73124 RE73780 RH12756 RH18016 RH33407 RH36044 RH37067 RH45280 RH45767 RH54452 RH67711 RH72989 RH73326 RP001001086 RP001001337 RP001001779 RP001004318 RP001004869 RP001009387 RP001013249 RP001014628 RP001018866 RP001018934 RP001022197 RP001028742 RP001029639 RP001030920 RP001032478 RP001033116 RP001036112 RP001039732 RP001043205 RP001045230 RP001047606 RP001049223 RP001050994 RP001052419 RP001053185 RP001056675 RP003507040 RP004032955 RP004068863 RP004088680 RP004113195 RP004124823 RP004137660 RP004146591 RP004163608 RP004183921 RP004202072 RP004204272 RP004205164 RP004209373 RP004214119 RP004219861 RP004220675 RP004220782 RP004224744 RP004225110 RP004225581 RP004227595 RP004228373 RP004230202 RP004231402 RP004236250 RP004237606 RP004240555 RP004241721 RP004244303 RP004260396 RP004260593 RP004262532 RP004348937 RP004353553 RP004388093 RP004400877 RP004415680 RP004427693 RP004433039 RP004436155 RP004439895 RP004447024 RP004456084 RP004459185 RP004464383 RP004466035 RP004471333 RP004475741 RP004486277 RP004488396 RP004502683 RP004504222 RP004508007 RP004514225 RP004517166 RP004526403 RP004528281 RP004532145 RP004532724 RP004537881 RP004540580 RP004541443 UT01953
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000117 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31151
Antibody Information
	monoclonal (Schulz et al., 2004, Hayashi and Carthew, 2004) polyclonal (Loureiro and Peifer, 1998, de la Roche and Bienz, 2007, Kessler and Müller, 2009, Riggleman et al., 1990)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: arm l(1)G0192 l(1)G0234 (Benos et al., 2001) Source for merge of: arm l(1)G0410 (Peter et al., 2002)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene has been transfected into Kc cells. (Fang et al., 2006) dsRNA made from templates generated with primers directed against this gene profoundly reduces the wg-signaling pathway. (Seto and Bellen, 2006) In order to activate pan protein, arm protein must enter the nucleus and form a complex with lgs and pygo proteins. (Thompson, 2004) Nuclear localisation of arm is necessary for Wnt pathway activation. (Tolwinski and Wieschaus, 2004) FlyBase curator comment: FBrf0161468 is an erratum for FBrf0151816, which has been retracted, see Struhl, 2004, Cell 116(3): 481. (Chan and Struhl, 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cells become round and detached. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) ci, tsh and arm may act as a complex. (Angelats et al., 2002) Different combinations of the proteins ci, tsh and arm appear to be employed for the specification of naked cuticle at distinct positions both along the anterior posterior axis and within individual trunk segments. (Angelats et al., 2002) FlyBase curator comment: FBrf0151816 has been retracted, see Struhl, 2004, Cell 116(3): 481. (Chan and Struhl, 2002) arm does not play a general role in inhibiting cell migration or process extension. (Loureiro et al., 2001) arm and pan act together with JNK signalling pathways in both ventral patterning and dorsal closure. (McEwen et al., 2000) fz and fz2 function downstream of wg and upstream of arm in the wg signalling pathway. (Bhanot et al., 1999) Membrane tethered arm cannot signal on its own, however it can function in adherens junctions. (Cox et al., 1999) Analysis of C-terminally truncated arm proteins suggests that the C-terminal domain of arm plays a complex role in wg signalling and the arm protein recruits the transcriptional machinery via multiple contact sites. (Cox et al., 1999) The arm/pan protein complex has a role in the activation of apoptosis during retinal development. Regulation of arm by Apc inhibits neuronal apoptosis during retinal development. (Ahmed et al., 1998) The pan gene product can function as either an activator or a repressor of wg-responsive genes depending on the state of the wg signalling pathway and thus the availability of arm, the pan product coactivator. In the absence of arm, pan acts to repress wg responsive genes, with the gro protein acting as a corepressor. (Cavallo et al., 1998) arm function in wg signal transduction is required early in neural development for determination of neuroblast fate. Later in neural development, the cell-cell adhesion function of arm is required for development of the correct axonal scaffold. (Loureiro and Peifer, 1998) Ectopic wg expression non-cell autonomously induces vg expression in leg discs and activated arm (a cytosolic transducer of wg signalling) cell-autonomously induces vg expression, indicating that vg expression is directly activated by wg signalling. (Maves and Schubiger, 1998) Segment polarity gene expression is necessary for the survival of specific rows of epidermal cells. (Pazdera et al., 1998) Apc expression pattern and preliminary genetic analysis suggest that it may not be an essential component of arm regulation in the wg pathway. (Hayashi et al., 1997) wg signals through arm. wg can activate arm in a cell line. (Nusse et al., 1997) A shg/arm complex has multiple functions for the regulation of organised cell adhesion events. (Oda et al., 1997) Mmus\Lef1 can form a stable complex with arm protein on the Ubx wg response sequence (WRS) and function in vivo depends on arm. (Riese et al., 1997) pan functions directly downstream of arm in the establishment of segment polarity. (van de Wetering et al., 1997) Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling. (Woods et al., 1997) Adherens junctions cannot assemble in the absence of arm, leading to dramatic defects in cell-cell adhesion. Embryonic epithelial cells lose adhesion to each other, round up and apparently become mesenchymal. Mutant cells also lose their normal cell polarity. These disruptions in the integrity of the epithelia block the appropriate morphogenetic movements of gastrulation. (Cox et al., 1996) Embryos mutant for arm and sdt baz double mutant embryos have very similar early phenotypes with respect to zonula adherens formation. Results suggest that early stages in the assembly of the zonula adherens are critical for the stability of the polarised blastoderm epithelium. (Muller and Wieschaus, 1996) The binding sites for shg and α-Cat are mapped, these bind independently of each other to arm and binding of each is required for the function of adherens junctions. arm is critical for wg signalling. arms roles in adherens junctions and wg signalling are independent. (Orsulic and Peifer, 1996) Yeast two-hybrid system and in vivo assays have identified a 76 amino acid region of arm that is necessary and sufficient for binding α-Cat and also that the N-terminal 258 amino acids of α-Cat interact with arm. A large region of arm, spanning six central arm repeats, is required for shg binding, whereas only 41 amino acids of shg are sufficient for arm binding. (Pai et al., 1996) dsh and arm, but not sgg are required for heart formation. (Park et al., 1996) arm is not required for wg self-refinement at the wing margin. (Rulifson et al., 1996) Overexpression of full length or truncated shg phenocopies wg. This is achieved by titrating arm away from a signalling function in the wg pathway. (Sanson et al., 1996) arm mutations mimic all effects of a wg mutation. sgg, dsh and arm function to transmit the wg signal in the midgut in the same way as they do in the epidermis. Results suggest the wg signal transduction pathway acts in all three germ layers, the ectoderm, mesoderm and endoderm. (Yu et al., 1996) Tethered arm has autonomous effects on the transcription of target genes. (Zecca et al., 1996) The arm gene product is required for wg-dependent bristle inhibition. (Cadigan and Nusse, 1995) The arm product has a role in cell-cell adhesion, gastrulation and epithelial sheet integrity. (Cox and Peifer, 1995) The arm locus encodes a truncated 82kD isoform specific to the nervous system. (Loureiro et al., 1995) arm forms part of the multi-protein adherins junction complex and in this role is critical for cell adhesion and the integrity of the actin cytoskeleton. One domain of arm is made of 12 copies of a degenerate motif, named the armadillo repeat. This motif modulates protein protein interactions. (Peifer et al., 1995) arm gene is indispensable for the transmission of the wg signal in distinct cells. (Wodarz and Nusse, 1995) arm, dsh and sgg encode elements of a unique wg signalling pathway that is used several times throughout development. (Couso et al., 1994) Direct wg autoregulation differs from wg signalling to adjacent cells in the importance of fu, smo and ci relative to sgg and arm. (Hooper, 1994) arm mutants display a disrupted actin cytoskeleton. (Knowles and Cooley, 1994) wg acts through dsh and arm to affect the expression of en and cuticle differentiation. (Noordermeer et al., 1994) Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events. (Patel, 1994) Endogenous arm is a phosphoprotein that demonstrates coupled phosphorylation of Ser/Tyr and Tyr in vivo. Phosphorylation is developmentally regulated and may play a role in wg signal transduction. (Peifer et al., 1994) Cells alter their intracellular distribution of arm protein in response to wg signal, accumulating increased levels of cytoplasmic arm relative to those of membrane-associated protein. Levels of cytoplasmic arm are also regulated by sgg. Double mutant analysis demonstrates that arm's role in wg signalling is direct and that arm functions downstream of wg and sgg. (Peifer et al., 1994) dsh and por act upstream of sgg, and arm acts downstream of sgg in the wg signalling pathway. (Siegfried et al., 1994) Cell culture assay of wg and arm gene expression demonstrates that the wg protein does not affect the rate of arm protein synthesis but presence of the wg protein causes increased stability of an otherwise rapidly decaying arm protein. wg protein from the co-culturing donor cells, in the extracellular matrix and soluble medium from donor cells also increases the levels of arm protein demonstrating that wg can act as a soluble extra cellular signalling molecule. (van Leeuwen et al., 1994) The arm gene product is part of a membrane-associated complex. This complex includes α-Cat and the arm-associated glycoprotein, aagp. The arm product co-localizes with junctions that resemble vertebrate adherens junctions in morphology and position. (Peifer, 1993) Germline arm mutations appear to disrupt processes requiring cell adhesion and integrity of the actin cytoskeleton, consistent with a role for the arm product in cell adhesive junctions. (Peifer et al., 1993) wg and en expression patterns are studied in all known segment polarity mutants to investigate the requirement of other segment polarity genes in mediating the maintenance of wg and en. (van den Heuvel et al., 1993) Ectopic uniform wg expression causes no change in the distribution of arm RNA, but protein distribution is quite different from that in wild type, being evenly distributed at high levels. nkd2 embryos have same pattern of arm RNA expression as those with uniform wg expression, but different protein distribution, with a high level all over, plus 2 stripes/segment where wg is expressed. (Noordermeer et al., 1992) arm may play a role in cell-cell adhesive junctions. (Peifer et al., 1992) A homolog of the arm plakoglobin in Drosophila may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions. This complex may also participate in the transmission of developmental information. (McCrea et al., 1991) The role of arm gene expression in pattern formation in imaginal discs has been examined. Mutations in arm and wg have indistinguishable embryonic consequences: the timing and pattern of wg loss in arm mutants is very similar. Clonal tissue with reduced levels of arm activity will only survive in regions furthest from regions of high levels of wg RNA. (Peifer et al., 1991) wg regulates accumulation of arm by post-transcriptional control, por and dsh are also required for this effect. (Riggleman et al., 1990) Role of arm in neurogenesis has been studied. (Patel et al., 1989) arm region has been molecularly cloned and characterised, the protein contains a series of novel repeats. arm RNA is abundant and uniformly distributed and expressed in a wide range of cell types in the embryo, unlike the transcript accumulation of other segment polarity genes. (Riggleman et al., 1989) A screen for X-linked genes that affect embryo morphology revealed arm. (Eberl and Hilliker, 1988) Genetic mosaics were used to determine that arm is autonomous at the level of the single cell. arm gene activity is required for embryonic development at least until extended germ band stages. (Wieschaus and Riggleman, 1987) arm mutants display mirror image duplication of denticle belts. (Wieschaus et al., 1984) Embryonic lethal; embryonic segmentation defective by time of germ-band shortening; naked cuticle ordinarily comprising the posterior two thirds of each segment replaced by mirror-image duplication of the anteriorly situated denticle belt; strong alleles delete first denticle row in abdominal segments. May have dorsal hole in cuticle. Embryonic CNS development quasi normal (Patel et al., 1989). Autonomous at the level of single cells as shown by denticulate clones of homozygous cells in the naked cuticle of abdominal segments in arm/+ embryos (Wieschaus and Riggleman, 1987). Clones of homozygous female germ cells arrested at stage 10 of oogenesis (Wieschaus and Noell, 1986). An exception is arm8 for which progeny from homozygous germ-line clones have been recovered (Klingsmith et al., 1989). Cell lethal in imaginal discs; although clones of homozygous cells not observed in adults, their formation seems to engender mirror-image duplications, which are not seen in response to homozygosing other cuticular cell lethals (Wieschaus). Transcript found with minor fluctuations in amount, in all cell types at all stages in development (Riggleman, Wieschaus and Schedl, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057317 NM_057318 NM_134273 NM_166912 NM_206605 RefSeq (Proteins) • NP_476665 NP_476666 NP_599100 NP_726775 NP_996328 DDBJ / EMBL / GenBank • AA391346 AA817498 AAB58731 AAF45686 AAF45687 AAF45688 AAK72233 AAK72234 AAK72235 AAK72236 AAK72237 AAK72238 AAK72239 AAK72240 AAK72241 AAK72242 AAK72243 AAK72244 AAK72245 AAM49894 AAN09064 AAS65246 AF001213 AF345663 AF345664 AF345665 AF345666 AF345667 AF345668 AF345669 AF345670 AF345671 AF345672 AF345673 AF345674 AF345675 AJ300028 AJ300264 AL021086 AL021106 AW942665 AY118525 CAA15935 CAA15946 CAA38350 CL868542 CS419459 CZ482354 X54468 Z32098 Entrez Gene - A searchable database of RefSeq genes. • 31151 UniProtKB/Swiss-Prot • P18824 UniProtKB/TrEMBL • Q95NY7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Armadillo-like helical (IPR011989) Beta-catenin (IPR013284) Armadillo-type fold (IPR016024)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57697 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000117 DroID - A comprehensive database of gene and protein interactions. • FBgn0000117 DRSC - Results from RNAi screens. • FBgn0000117 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000117 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11579-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000117 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 85334 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31151 InParanoid A subset of ortholog calls from InParanoid. • AAEL002887-PA Aedes aegypti (mosquito) AGAP001043-PA Anopheles gambiae (mosquito) XP_391947.2 Apis mellifera (honey bee) XP_001943912.1 Acyrthosiphon pisum (pea aphid) 124698 Branchiostoma floridae (lancelet) XP_001898435.1 Brugia malayi (roundworm nematode) BGIBMGA006959-PA Bombyx mori (silk worm) ENSBTAP00000021838 Bos taurus (bovine) CN07057 Caenorhabditis brenneri (small nematode) CBP19704 Caenorhabditis briggsae (nematode) CE19974 Caenorhabditis elegans (worm) ENSCAFP00000032261 Canis familiaris (dog) ENSCINP00000014417 Ciona intestinalis (sea squirt) JA02369 Caenorhabditis japonica (nematode) CPIJ006700 Culex pipens (mosquito) ENSCPOP00000002653 Cavia porcellus (guinea pig) RP05688 Caenorhabditis remanei (nematode) ENSCSAVP00000006256 Ciona savignyi (sedentary tunicate) 157160 Capitella spl (polychaete worm) 290530 Daphnia pulex (daphnia) ENSDARP00000032935 Danio rerio (zebra fish) ENSECAP00000005466 Equus caballus (horse) ENSGACP00000007992 Gymnopilus aculeatus (mushroom) ENSGALP00000019402 Gallus gallus (chicken) 189420 Hypsipyla robusta (cedar shoot borer) ENSP00000385604 Homo sapiens (human) ISCW023688-PA Ixodes scapularis (deer tick) 205205 Lottia gigantea (owl limpet) ENSMODP00000014004 Monodelphis domestica (gray opossum) ENSMMUP00000019198 Macaca mulatta (rhesus monkey) ENSMUSP00000007130 Mus musculus (house mouse) XP_001603109.1 Nasonia vitripennis (wasp) ENSOANP00000010865 Ornithorynchus anatinus (platypus) ENSORLP00000007357 Oryzias latipes (japanese killifish) PHUM003629-PA Pediculus humanus (human body louse) PHUM003645-PA Pediculus humanus (human body louse) PP22631 Pristionchus pacificus (nematode) ENSPPYP00000015644 Pongo pygmaeus (orangutan) 139436 Phytophthora sojae (root rot pathogen) ENSPTRP00000058940 Pan troglodytes (chimpanzee) ENSRNOP00000026016 Rattus norvegicus (norway rat) Smp_023550 Schistosoma mansoni (trematode parasite) XP_001175634.1 Strongylocentrotus purpuratus (purple sea urchin) 22780 Trichoplax adhaerens (metazoa) XP_971985.1 Tribolium castaneum (red flour beetle) Tc00.1047053511283.160 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022288 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008263 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000030302 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/armadilo.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31151 modMine - Data generated by the modENCODE project. • FBgn0000117 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15051 PB10148 NV16988 LH21342 ISCW023688 FBgn0234484 FBgn0218378 FBgn0206283 FBgn0188022 FBgn0173844 JGI_V11_290530 FBgn0248971 FBgn0248967 FBgn0144490 FBgn0125316 FBgn0104958 FBgn0096481 CPIJ006700 BGIBMGA006959 ACYPI007086 ACYPI003226 GB15531 GB12463 ARM_ANOGA ARM_AEDAE PHUM000560 PHUM000580 PHUM280840 GLEAN_12389 GLEAN_12388
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	Arm (Wei et al., 2004, Solon et al., 2009, Natzle et al., 2008, Wildonger et al., 2005, Nam and Choi, 2003, Noureddine et al., 2002, Glenn and Searles, 2001, Theisen et al., 2000, Zhang et al., 2005, Waldrop et al., 2006, Deng and Meller, 2006, Pepple et al., 2007, Zhou et al., 2007, Kennell and Cadigan, 2007, McCartney et al., 2006, O'Reilly et al., 2006, Laplante and Nilson, 2006, Janody and Treisman, 2006, Kim et al., 2006, Colombani et al., 2006, Wei et al., 2005, Parker et al., 2007, Stadeli, 2006, Franch-Marro et al., 2006, Takacs et al., 2008, Lu and Bilder, 2005, Blair et al., 2006, Genevet et al., 2010, Schneider et al., 2006, Simoes et al., 2006, Tountas and Fortini, 2007, Tolwinski, 2007, Kolsch et al., 2007, Somers and Chia, 2005, Bras-Pereira et al., 2006, Tripura et al., 2011, Zhang and Ward, 2009, Brown et al., 2006, Meyer et al., 2006, D'Alterio et al., 2005, Park et al., 2003, Mirkovic et al., 2011, Bakal et al., 2007, Baena-Lopez et al., 2009, Singh et al., 2010, Fox and Peifer, 2007, Wu et al., 2007, Alexandre et al., 2008, Colosimo and Tolwinski, 2008, Hoffmans and Basler, 2007, Li et al., 2007, Cong et al., 2004, Matsubayashi et al., 2004, Jafar-Nejad et al., 2005, Fernández et al., 2011, Yamashita et al., 2005, Marques, 2005, Fernández et al., 2007, Langdon et al., 2006, Nam and Choi, 2006, Philippakis et al., 2006, Boettner and Van Aelst, 2007, Mendes et al., 2006, Neumuller et al., 2008, Chan et al., 2007, Chan et al., 2008, Weaver and Krasnow, 2008, Wang and Jiang, 2004, Luo et al., 2007, Blauwkamp et al., 2008, Wang et al., 2006, Laprise et al., 2006, Kitadate et al., 2007, Escudero et al., 2007, Estella et al., 2008, Denef et al., 2008, Desprat et al., 2008, Bastock and Strutt, 2007, Buttrick et al., 2008, Li et al., 2008, Medioni et al., 2008, Homem and Peifer, 2008, Yasugi et al., 2008, Nusinow et al., 2008, Lin et al., 2007, Nam et al., 2007, Lechner et al., 2007, Polesello and Tapon, 2007, Carrera et al., 2008, Mulinari et al., 2008, Zeng et al., 2008, Georgiou et al., 2008, Spasić et al., 2008, Schweizer and Varmus, 2003, Firth and Baker, 2009, Hayden et al., 2007, Harris and Tepass, 2008, Mirouse et al., 2009, Strutt and Strutt, 2008, Chang et al., 2008, Cavey et al., 2008, Rafel and Milán, 2008, Peterson-Nedry et al., 2008, Lin and Gubb, 2009, Lee et al., 2009, Kessler and Müller, 2009, Wright and Tjian, 2009, Escudero and Freeman, 2007, Kim et al., 2007, Singh et al., 2006, Genevet et al., 2009, Glavic et al., 2009, Laprise et al., 2009, Bosveld et al., 2008, Urbano et al., 2009, Pek et al., 2009, Baena-Lopez et al., 2008, Jang et al., 2009, Yano et al., 2009, Zhang et al., 2009, Massarwa et al., 2009, Campbell et al., 2009, Li et al., 2007, McGill et al., 2009, Bao and Cagan, 2005, Zhang et al., 2005, Eid et al., 2008, Bertet et al., 2009, Fetting et al., 2009, Sato et al., 2008, Zhang et al., 2009, Langton et al., 2009, Eivers et al., 2009, Fan et al., 2003, Buceta et al., 2007, Bolivar et al., 2006, Sanders et al., 2009, Martinez et al., 2009, Mao et al., 2008, Mathur et al., 2010, Robinson et al., 2010, Zimmerman et al., 2010, Morais-de-Sá et al., 2010, Gallet et al., 2008, Firth and Baker, 2007, Varelas et al., 2010, Taniue et al., 2010, Li et al., 2008, Walther and Pichaud, 2010, Chen et al., 2009, Levine et al., 2010, Quijano et al., 2010, Mukai et al., 2010, Pinal et al., 2006, Neubueser and Hipfner, 2010, Simone and DiNardo, 2010, Tikhmyanova et al., 2010, Reddy et al., 2010, Nilton et al., 2010, Kaido et al., 2009, Harumoto et al., 2010, Kleinschmit et al., 2010, Djiane et al., 2011, Laplante and Nilson, 2011, Kwon et al., 2004, Laplante et al., 2010, König et al., 2011, Mirkovic et al., 2011, Letizia et al., 2011, Zhang et al., 2011, Richard et al., 2009, Bahri et al., 2010, Badouel et al., 2009) arm (Hutterer et al., 2004, Thompson, 2004, Peifer et al., 1994, Singh et al., 2006, DasGupta et al., 2005, Pastor-Pareja et al., 2004, Fung et al., 2007, Smelkinson and Kalderon, 2006, Rodrigues et al., 2005, Fox et al., 2005, Murray et al., 2006, Lim and Tomlinson, 2006, McEwen and Peifer, 2005, Stultz et al., 2006, Joshi et al., 2006, Tolwinski and Wieschaus, 2004, Harris and Peifer, 2004, Ryoo et al., 2004, Molnar and de Celis, 2006, Furlong, 2005, Kent et al., 2006, Chao et al., 2007, Estrada et al., 2006, Bartscherer et al., 2006, Fang et al., 2006, Mirkovic and Mlodzik, 2006, Charroux et al., 2006, Blanco et al., 2010, Lim and Choi, 2004, Takada et al., 2005, Takaesu et al., 2005, Zhang et al., 2006, Mehta et al., 2005, Mehta, 2005, Ayyub et al., 2005, Colosimo and Tolwinski, 2006, Pacquelet and Rorth, 2005, Kremer et al., 2010, Langevin et al., 2005, Zhang et al., 2006, Harris and Peifer, 2005, Benchabane et al., 2011, Benchabane et al., 2011, Gonsalves et al., 2011, Seto and Bellen, 2006, Wood et al., 2006, Takacs et al., 2008, Ma et al., 2006, Staedeli and Basler, 2005, Bakal et al., 2007, Grieder et al., 2007, Papadopoulou et al., 2004, Ahmed et al., 1998, Reig et al., 2007, McCaffrey et al., 2006, Kaltenbach et al., 2007, Szafranski and Goode, 2007, Worringer and Panning, 2007, Parker et al., 2008, Zecca and Struhl, 2007, Koizumi et al., 2007, Kankel et al., 2007, Jankovics and Brunner, 2006, Harris and Peifer, 2007, Goodfellow et al., 2007, Takashima et al., 2008, Grammont, 2007, Jang et al., 2008, Rusan et al., 2008, De Renzis et al., 2007, Somorjai and Martinez-Arias, 2008, Estella and Mann, 2008, Benchabane et al., 2008, Shindo et al., 2008, Pope and Harris, 2008, O'Keefe et al., 2007, Baig-Lewis et al., 2007, Bhat, 2007, Fiehler and Wolff, 2007, Wang and Riechmann, 2007, Fiehler and Wolff, 2008, Seppa et al., 2008, Melani et al., 2008, Tran et al., 2008, Price et al., 2006, Leibfried et al., 2008, Miech et al., 2008, Cliffe et al., 2004, Sokac and Wieschaus, 2008, Liu et al., 2008, Romani et al., 2009, Wodarz et al., 2006, Simcox et al., 2008, Gorfinkiel and Arias, 2007, Blankenship et al., 2007, Mitchell et al., 2008, McKay et al., 2009, Mao and Freeman, 2009, Lin et al., 2008, Dichtel-Danjoy et al., 2009, Benítez et al., 2009, Chiang et al., 2009, Xie et al., 2005, Maeda et al., 2008, Worringer et al., 2009, Sinenko et al., 2009, Dworkin et al., 2009, Lee et al., 2009, Svendsen et al., 2009, Kennell et al., 2008, Sawyer et al., 2009, Woolworth et al., 2009, Igaki et al., 2006, Chang et al., 2008, Widmann and Dahmann, 2009, Berger et al., 2005, Pereira et al., 2006, Brás-Pereira and Casares, 2008, Parrish et al., 2009, Fung et al., 2009, Kalamegham et al., 2007, Viquez et al., 2009, Popodi et al., 2010-, Hatton-Ellis et al., 2007, DasGupta et al., 2007, Weake and Scott, 2007, Franz and Riechmann, 2010, Zhao et al., 2008, Baig et al., 2010, Duchi et al., 2010, Lin et al., 2010, Sekine et al., 2008, Jin et al., 2008, Gurunathan et al., 2004, Jones et al., 2010, Buechling et al., 2010, Aldaz et al., 2010, Djiane and Mlodzik, 2010, Martin et al., 2010, Godin et al., 2010, Corrigall et al., 2007, Chen et al., 2010, Sato et al., 2006, Fichelson et al., 2010, Tikhmyanova et al., 2010, Lawrence et al., 2000, Fernandez-Minan et al., 2008, Fiedler et al., 2011, Silver et al., 2007, Kaplan et al., 2011, Kaplan et al., 2009, Simões et al., 2010, Schiemann et al., 2010, Bhambhani et al., 2011, Tolwinski, 2009, Yasugi et al., 2010, Schiemann et al., 2010, Brodland et al., 2010) ARM (Cox et al., 2001, Ward et al., 2006, Theisen et al., 2007, Ash et al., 2007, Takada et al., 2005, Hackney et al., 2007, Starz-Gaiano et al., 2008, Pallavi and Shashidhara, 2005, McDonald et al., 2008, Albornoz et al., 2008) CG11579 (Kim et al., 2004, Bourbon et al., 2002, Whitfield, 2001.2.28, Benos, 2000.12.13, Goldstein and Gunawardena, 2000, Hynes and Zhao, 2000, Grieder et al., 2007, Keleman et al., 2009.8.5, Gandhi et al., 2007, Ni et al., 2008, Ni et al., 2011.7.19) Dm Arm (Konikoff et al., 2010) EG:86E4.6 (Benos et al., 2001, Benos, 2000.12.13, ) l(1)2Bv   l(1)arm (Perrimon and Mahowald, 1987) l(1)G0192 (Schaefer et al., 1999.12.2, ) l(1)G0234 (Schaefer et al., 1999.12.10, ) l(1)G0410 (Benos et al., 2001, ) t12687 ALR Dm (Alvarez-Venegas and Avramova, 2002) β-cat (Bejsovec, 2005, Gonsalves et al., 2011, Major and Irvine, 2005, Bertet et al., 2009, Jones et al., 2010) β-Cat (Cavey et al., 2008) βcat (Bertet et al., 2009, Jones et al., 2010) β-cat-arm (DasGupta et al., 2005) β-catenin/Arm (Bhandari and Shashidhara, 2001)
Name Synonym	Armadillo (Wei et al., 2004, Solon et al., 2009, Natzle et al., 2008, Wang et al., 2000, Townsley et al., 2004, Djiane et al., 2006, Tepass and Harris, 2007, Zhang et al., 2005, Zimmerman et al., 2007, Galletti et al., 2007, Bhambhani et al., 2007, Fox et al., 2005, Keller, 2006, Koppen et al., 2006, Janody and Treisman, 2006, Mosimann et al., 2006, Kim et al., 2006, Nystul and Spradling, 2006, Jones and Bejsovec, 2007, Parker et al., 2007, He and Axelrod, 2006, Bienz, 2006, Schwabe et al., 2005, Blair et al., 2006, Cordero and Cagan, 2010, Romani et al., 2007, Tountas and Fortini, 2007, Silva et al., 2006, Niki et al., 2006, Niki, 2006, Kolsch et al., 2007, Tripura et al., 2011, Tiwari and Roy, 2009, Maqbool et al., 2006, Theisen et al., 2007, Colosimo and Tolwinski, 2006, Ash et al., 2007, Zhang and Ward, 2009, Brown et al., 2006, Zhai et al., 2006, D'Alterio et al., 2005, Sasaki et al., 2007, Wang et al., 2006, Park et al., 2003, Sekyrova et al., 2010, Baena-Lopez et al., 2009, Silva, 2006, Wu et al., 2007, He et al., 2005, Bhambhani et al., 2008, Desai et al., 2008, Sarpal et al., 2008, Alexandre et al., 2008, Song et al., 2008, Zimmerman et al., 2008, Wehrli et al., 2008, Hoffmans and Basler, 2007, Li et al., 2007, Cong et al., 2004, Matsubayashi et al., 2004, Papadopoulou et al., 2004, Gonzalez-Reyes, 2003, Lecuit, 2004, Yamashita et al., 2005, Marques, 2005, Larson et al., 2008, Fernández et al., 2007, van IJzendoorn, 2006, Langdon et al., 2006, Nam and Choi, 2006, Ren et al., 2007, Hackney et al., 2007, Boettner and Van Aelst, 2007, Parker et al., 2008, Mendes et al., 2006, Emoto et al., 2006, Weaver and Krasnow, 2008, Luo et al., 2007, Wang et al., 2006, Blankenship et al., 2006, Jaekel and Klein, 2006, Kitadate et al., 2007, Corrigall et al., 2007, Estella et al., 2008, Desprat et al., 2008, Bogard et al., 2007, Grammont, 2007, Li et al., 2008, Medioni et al., 2008, Rusan et al., 2008, de la Roche and Bienz, 2007, Somorjai and Martinez-Arias, 2008, Shindo et al., 2008, Lin et al., 2007, Polesello and Tapon, 2007, Seppa et al., 2008, Zeng et al., 2008, Llense and Martín-Blanco, 2008, Melani et al., 2008, Port et al., 2008, Tran et al., 2008, Georgiou et al., 2008, Leibfried et al., 2008, Schweizer and Varmus, 2003, Cliffe et al., 2004, Yan et al., 2008, Wodarz et al., 2006, Dansereau and Lasko, 2008, Harris and Tepass, 2008, Mirouse et al., 2009, Gorfinkiel and Arias, 2007, Strutt and Strutt, 2008, Chang et al., 2008, Cavey et al., 2008, Peterson-Nedry et al., 2008, Lin et al., 2008, Grusche et al., 2009, Kessler and Müller, 2009, Wright and Tjian, 2009, Mok et al., 2005, Escudero and Freeman, 2007, Kim et al., 2007, Menzel et al., 2008, Mirth et al., 2009, Genevet et al., 2009, Bosveld et al., 2008, Urbano et al., 2009, Pek et al., 2009, Mieszczanek et al., 2008, Jang et al., 2009, Sheng et al., 2009, Zhang et al., 2009, Campbell et al., 2009, Webb et al., 2009, Li et al., 2007, Warner and Longmore, 2009, Eid et al., 2008, Fetting et al., 2009, Sato et al., 2008, Brás-Pereira and Casares, 2008, Parrish et al., 2009, Glavic et al., 2009, Fung et al., 2009, Choi et al., 2008, Eivers et al., 2009, Buceta et al., 2007, Pines et al., 2010, Sanders et al., 2009, Martinez et al., 2009, Mao et al., 2008, Mathur et al., 2010, Robinson et al., 2010, Franz and Riechmann, 2010, Takashima et al., 2008, Gallet et al., 2008, Lighthouse et al., 2008, Lin et al., 2010, Li et al., 2008, Quijano et al., 2010, Martin et al., 2010, Mukai et al., 2010, Godin et al., 2010, Neubueser and Hipfner, 2010, Simone and DiNardo, 2010, Reddy et al., 2010, Nilton et al., 2010, Kaido et al., 2009, Laplante and Nilson, 2011, Kaplan and Tolwinski, 2010, Bhandari and Shashidhara, 2001, Kwon et al., 2004, Zeng et al., 2010, Buchon et al., 2010, He et al., 2010, Kaplan et al., 2009, Laplante et al., 2010, König et al., 2011, Zappia et al., 2011, Bhambhani et al., 2011, Mirkovic et al., 2011, Letizia et al., 2011, Albornoz et al., 2008, Zhang et al., 2011, Bahri et al., 2010, Badouel et al., 2009) armadillo (Ward et al., 2006, Morris and Dyson, 2007, Parker, 2006, Quaiser, 2006, Clevers, 2006, Beronja et al., 2005, Ohlstein and Spradling, 2007, Nurminsky, 2007, Ayyub et al., 2005, Quinones et al., 2010, Pacquelet and Rorth, 2005, Kremer et al., 2010, Takada et al., 2005, Prestel et al., 2010, Wood et al., 2006, Montell, 2006, Payne and Braun, 2006, Ma et al., 2006, Staedeli and Basler, 2005, Hayward et al., 2005, Bakal et al., 2007, Reig et al., 2007, McCaffrey et al., 2006, Baer et al., 2007, Philippakis et al., 2006, Kaltenbach et al., 2007, Hayward et al., 2006, Gates et al., 2007, Kankel et al., 2007, Jang et al., 2008, Fiehler and Wolff, 2007, Wang and Riechmann, 2007, Dimitri et al., 2003, Romani et al., 2009, Blankenship et al., 2007, Mitchell et al., 2008, Dichtel-Danjoy et al., 2009, Sevrioukov et al., 2007, Desai et al., 2009, Larsen et al., 2009, Widmann and Dahmann, 2009, Berger et al., 2005, Kalamegham et al., 2007, Viquez et al., 2009, DasGupta et al., 2007, Weake and Scott, 2007, Neely et al., 2010, Zhao et al., 2008, Goldbach et al., 2010, Fichelson et al., 2010, Zappe et al., 2006, Kim et al., 2010, Lawrence et al., 2000, Fernandez-Minan et al., 2008, Fiedler et al., 2011, Silver et al., 2007, Schiemann et al., 2010, Richard et al., 2009) Armadillo/bgr;-catenin (Rao et al., 2008) Armadillo/β-catenin (Speder et al., 2006, Kiger et al., 2007) Armadillo(Arm)/beta-catenin (Bejsovec et al., 2007) b-catenin (Wang and Hartenstein, 2003, Nouri et al., 2002, Wang et al., 2001, Woolworth and Hsu, 2007) Beta-catenin (Hsouna and Hsu, 2005, Ackley and Jin, 2004, Garber and Helfand, 2004) beta-catenin (Kalderon, 2002, Wang et al., 2000, Baum, 2006, Georgiou et al., 2008, Desai et al., 2009, Tikhmyanova et al., 2010) catenin (Hayashi et al., 2003) Β-catenin (Myat et al., 2005, Meinhardt, 2004, He et al., 2004, Rorth, 2002, Nusse, 2001, Niki et al., 2006, Tikhmyanova et al., 2010) Β-catenin/Arm (Jaiswal et al., 2006) β-catenin (Harris et al., 2005, Drewes, 2004, Lin, 2003, Maves and Schubiger, 2003, Wallenfang and Matunis, 2003, Emerson and Van Vactor, 2002, Lopez-Schier, 2003, Lecuit and Pilot, 2003, Perez-Moreno et al., 2003, Chihara et al., 2003, Barth and Nelson, 2002, Renfranz and Beckerle, 2002, Fortini, 2001, Knox and Brown, 2002, Magie et al., 2002, Kowalczyk and Moses, 2002, Huppert and Kopan, 2001, Kopan and Goate, 2002, Novak and Dedhar, 1999, Noll et al., 2000, Schock and Perrimon, 2000, Zhang and Derynck, 1999, Maroteaux et al., 1999, Townsley et al., 2004, Hayashi and Carthew, 2004, Geisbrecht and Montell, 2004, Pacquelet et al., 2003, Pirraglia et al., 2006, Leptin, 2005, Heeg-Truesdell, 2006, Murray et al., 2006, Wei et al., 2005, Quaiser, 2006, Nystul and Spradling, 2006, Bienz, 2006, Nurminsky, 2007, Colosimo and Tolwinski, 2006, Holland et al., 2005, Pacquelet and Rorth, 2005, Baena-Lopez et al., 2009, Woolworth and Hsu, 2008, Kapelnikov et al., 2008, Lecuit, 2004, Marques, 2005, van IJzendoorn, 2006, Lin, 2008, Pirraglia et al., 2006, Buttrick et al., 2008, de la Roche and Bienz, 2007, Wang and Riechmann, 2007, Leibfried et al., 2008, Sese et al., 2006, Dansereau and Lasko, 2008, Harris and Tepass, 2008, Gorfinkiel and Arias, 2007, Blankenship et al., 2007, Cavey et al., 2008, Niemitz, 2005, Sato et al., 2008, Takashima et al., 2008, Goldbach et al., 2010, Jones et al., 2010, Mukai et al., 2010, Godin et al., 2010, Pinal et al., 2006, Fichelson et al., 2010, Ji et al., 2008, Buchon et al., 2010, Silver et al., 2007, Kaplan et al., 2009, Martin et al., 2010, Simões et al., 2010, Bhambhani et al., 2011) β-Catenin (Scott and Stainier, 2003, Schober and Perrimon, 2002, Cadigan, 2002, Behrens, 2000, Margolis and Borg, 2005, Seppa et al., 2008, Llense and Martín-Blanco, 2008, Melani et al., 2008, Eivers et al., 2009, Franz and Riechmann, 2010, Simone and DiNardo, 2010, Letizia et al., 2011) βcatenin (Gettings et al., 2010, Levine et al., 2010)
Secondary FlyBase IDs
	FBgn0029069 FBgn0040191 FBgn0045040
References ( 1412 )
Generate a list of	All references relating to this gene ( 1412 )
List References by type	Research paper  ( 853 ) Supplementary material  ( 22 ) Review  ( 282 ) Erratum  ( 4 ) Retraction  ( 1 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 198 ) FlyBase analysis  ( 3 ) Conference report  ( 14 ) Meeting report  ( 1 ) Stock list  ( 1 ) Letter  ( 7 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 5 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Poem  ( 1 )
Recent research papers ( 75 )
	Benchabane et al., 2011, EMBO J. 30(8): 1444--1458 Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544] Bhambhani et al., 2011, EMBO J. 30(10): 2031--2043 The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. [FBrf0213805] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Fiedler et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(5): 1937--1942 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating {beta}-catenin. [FBrf0212953] Gonsalves et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(15): 5954--5963 An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. [FBrf0214389] Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. [FBrf0216680] Kaplan et al., 2011, PLoS ONE 6(4): e18616 Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis. [FBrf0213424] König et al., 2011, EMBO J. 30(8): 1549--1562 Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. [FBrf0213531] Laplante and Nilson, 2011, J. Cell Biol. 192(2): 335--348 Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. [FBrf0212838] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Mirkovic et al., 2011, Nat. Struct. Mol. Biol. 18(6): 665--672 Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. [FBrf0213849] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Swarup and Verheyen, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(24): 9887--9892 Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. [FBrf0214241] Tripura et al., 2011, Int. J. Dev. Biol. 55(6): 583--590 Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila. [FBrf0216296] Xu et al., 2011, Dev. Biol. 354(1): 31--43 EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. [FBrf0213634] Zappia et al., 2011, PLoS ONE 6(5): e19715 M6 membrane protein plays an essential role in Drosophila oogenesis. [FBrf0213770] Zhang et al., 2011, Development 138(3): 455--464 Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. [FBrf0212692] Aldaz et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(32): 14217--14222 Live imaging of Drosophila imaginal disc development. [FBrf0211511] Bahri et al., 2010, Development 137(12): 2023--2032 The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. [FBrf0210918] Baig et al., 2010, Genetics 184(3): 731--744 The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. [FBrf0210399] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Brodland et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(51): 22111--22116 Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila. [FBrf0212586] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Buechling et al., 2010, Curr. Biol. 20(14): 1263--1268 Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor. [FBrf0211368] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15810--15815 The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. [FBrf0211766] Cordero and Cagan, 2010, Dev. Dyn. 239(3): 875--884 Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [FBrf0210104] Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Duchi et al., 2010, Development 137(9): 1493--1503 Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability. [FBrf0210606] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Genevet et al., 2010, Dev. Cell 18(2): 300--308 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. [FBrf0211094] Gettings et al., 2010, PLoS Biol. 8(6): e1000390 JNK Signalling Controls Remodelling of the Segment Boundary through Cell Reprogramming during Drosophila Morphogenesis. [FBrf0211014] Godin et al., 2010, EMBO J. 29(14): 2433--2445 Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. [FBrf0211344] Goldbach et al., 2010, Mol. Biol. Cell 21(9): 1482--1493 Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. [FBrf0210683] Harumoto et al., 2010, Dev. Cell 19(3): 389--401 Atypical cadherins dachsous and fat control dynamics of noncentrosomal microtubules in planar cell polarity. [FBrf0211754] He et al., 2010, Nat. Cell Biol. 12(12): 1133--1142 Tissue elongation requires oscillating contractions of a basal actomyosin network. [FBrf0212453] Jones et al., 2010, J. Cell Sci. 123(13): 2179--2189 Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. [FBrf0211056] Kaplan and Tolwinski, 2010, J. Cell Sci. 123(18): 3157--3165 Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. [FBrf0211705] Kim et al., 2010, Mol. Cells 29(1): 93--98 Blood-brain barrier defects associated with Rbp9 mutation. [FBrf0210543] Kleinschmit et al., 2010, Dev. Biol. 345(2): 204--214 Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. [FBrf0211640] Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312 Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842] Kremer et al., 2010, Dev. Biol. 337(1): 110--123 In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin. [FBrf0209417] Laplante et al., 2010, Dev. Dyn. 239(9): 2509--2519 Echinoid regulates tracheal morphology and fusion cell fate in Drosophila. [FBrf0211771] Levine et al., 2010, Dev. Biol. 344(1): 196--209 Opposing interactions between Drosophila Cut and the C/EBP encoded by Slow Border Cells direct apical constriction and epithelial invagination. [FBrf0211314] Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49 Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721] Martin et al., 2010, J. Cell Biol. 188(5): 735--749 Integration of contractile forces during tissue invagination. [FBrf0210158] Mathur et al., 2010, Science 327(5962): 210--213 A transient niche regulates the specification of Drosophila intestinal stem cells. [FBrf0209706] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Mukai et al., 2010, EMBO J. 29(13): 2114--2125 Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. [FBrf0211204] Neely et al., 2010, Cell 141(1): 142--153 A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. [FBrf0210524] Neubueser and Hipfner, 2010, Mol. Biol. Cell 21(16): 2869--2879 Overlapping roles of Drosophila drak and rok kinases in epithelial tissue morphogenesis. [FBrf0211530] Nilton et al., 2010, Development 137(14): 2427--2437 Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components. [FBrf0211147] Pines et al., 2010, Development 137(6): 913--922 The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. [FBrf0210124] Prestel et al., 2010, Mol. Cell 38(6): 815--826 The Activation Potential of MOF Is Constrained for Dosage Compensation. [FBrf0211211] Quijano et al., 2010, PLoS ONE 5(7): e11619 The Sno Oncogene Antagonizes Wingless Signaling during Wing Development in Drosophila. [FBrf0211340] Quinones et al., 2010, J. Cell Biol. 189(2): 353--367 I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. [FBrf0210570] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Schiemann et al., 2010, BMC Mol. Biol. 11: 80 Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila. [FBrf0212392] Schiemann et al., 2010, Biochem. Biophys. Res. Commun. 402(4): 699--704 The importance of location and orientation of male specific lethal complex binding sites of differing affinities on reporter gene dosage compensation in Drosophila. [FBrf0212385] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Simone and DiNardo, 2010, Development 137(8): 1385--1394 Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. [FBrf0210407] Simões et al., 2010, Dev. Cell 19(3): 377--388 Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation. [FBrf0211783] Singh et al., 2010, J. Cell. Physiol. 223(2): 500--510 Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. [FBrf0210092] Suzanne et al., 2010, Curr. Biol. 20(19): 1773--1778 Coupling of apoptosis and L/R patterning controls stepwise organ looping. [FBrf0212013] Taniue et al., 2010, Development 137(10): 1755--1764 Sunspot, a link between Wingless signaling and endoreplication in Drosophila. [FBrf0210642] Tikhmyanova et al., 2010, PLoS ONE 5(8): e12369 Dcas supports cell polarization and cell-cell adhesion complexes in development. [FBrf0211678] Varelas et al., 2010, Dev. Cell 18(4): 579--591 The Hippo pathway regulates Wnt/beta-catenin signaling. [FBrf0210631] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Yasugi et al., 2010, Development 137(19): 3193--3203 Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. [FBrf0211765] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Zhang et al., 2010, Cell Death Differ. 17(10): 1551--1565 Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73. [FBrf0211791] Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66 Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...