FlyBase Gene Report: Dmel\arr

General Information

Symbol

Dmel\arr

Species

D. melanogaster

Name

arrow

Annotation Symbol

CG5912

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000119

Gene Model Status

Current

Stock Availability

24 publicly available

Gene Snapshot

arrow (arr) encodes a type I trans-membrane protein and functions as an obligate co-receptor with the product of fz for the ligand encoded by wg in the canonical Wnt signaling pathway. The product of arr is involved in developmental patterning, cell survival and growth regulation. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Pathway
Red Book
Interactive Fly

Also Known As

LRP, LRP6, LRP5/6, CT15575, l(2)k08131

Key Links

Genomic Location

Cytogenetic map

50A9-50A11

Sequence location

2R:13,453,640..13,483,229 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13453640..13483229

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables coreceptor activity

inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084

(Schweizer and Varmus, 2003)

enables protein binding

inferred from physical interaction with FLYBASE:Axn; FB:FBgn0026597

(Yang et al., 2016)

enables Wnt-activated receptor activity

inferred from direct assay

(Rives et al., 2006)

enables Wnt-protein binding

inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084

(Piddini et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (9 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in canonical Wnt signaling pathway

inferred from mutant phenotype

(Kaur et al., 2017, Baig-Lewis et al., 2007, Povelones and Nusse, 2005, Tolwinski et al., 2003, Wehrli et al., 2000)

inferred from genetic interaction with FLYBASE:dsh; FB:FBgn0000499

(Wehrli et al., 2000)

inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084

(Schweizer and Varmus, 2003)

inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797

(Tolwinski et al., 2003)

involved_in cell elongation involved in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Widmann and Dahmann, 2009)

involved_in compound eye morphogenesis

inferred from mutant phenotype

(Tomlinson, 2003)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from mutant phenotype

(Wehrli et al., 2000)

involved_in leg disc pattern formation

inferred from mutant phenotype

(Wehrli et al., 2000)

involved_in long-term memory

inferred from mutant phenotype

(Tan et al., 2013)

involved_in nervous system development

inferred from mutant phenotype

(Koizumi et al., 2007)

involved_in regulation of compound eye pigmentation

inferred from mutant phenotype

(Lim and Tomlinson, 2006)

involved_in segment polarity determination

inferred from mutant phenotype

(Tolwinski et al., 2003, Wehrli et al., 2000)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

colocalizes_with early endosome

inferred from direct assay

(Rives et al., 2006)

colocalizes_with late endosome

inferred from direct assay

(Rives et al., 2006)

located_in plasma membrane

inferred from direct assay

(Rives et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Pathway (FlyBase)

Wnt-TCF Signaling Pathway Core Components

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Wnt-TCF Signaling Pathway Core Components -: The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

arr: arrow

Embryonic lethal. Additional denticle bands anterior and posterior to normal denticle bands, especially in ventral midline. Strongest at 18.

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\arr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

arr-RA

FBtr0087702

NM_079998

6024

1678

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

arr-PA

FBpp0086821

187.5

1678

7.00

NP_524737

AAF58373

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\arr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

arr_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with early endosome

inferred from direct assay

(Rives et al., 2006)

colocalizes_with late endosome

inferred from direct assay

(Rives et al., 2006)

located_in plasma membrane

inferred from direct assay

(Rives et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\arr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\arr

View exonic expression by tissue for Dmel\arr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000119

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000119

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5912-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5912

Flygut - An atlas of the Drosophila adult midgut

FBgn0000119

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\arr

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of arr

Transgenic constructs containing regulatory region of arr

Deletions and Duplications ( 5 )

Disrupted in

Df(2R)8-104

(Vaizel-Ohayon and Schejter, 1999)

Df(2R)AA1

(Metcalfe et al., 2010)

Df(2R)BSC274

(Kahsai et al., 2016)

Df(2R)CX1

(Baker, 2005.1.6, BDGP Project Members, 1994-1999)

Not disrupted in

Df(2R)vg-B

(BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | partially | recessive | somatic clone

arr^unspecified

lethal

arr^MI03803

lethal, with Scer\GAL4^Act5C.PU

lethal, with Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH

lethal (with Df(2R)BSC274)

arr²

lethal | recessive

arr^k08131

lethal - all die before end of embryonic stage

arr¹

lethal - all die before end of embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

arr^GD2617

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

arr^GD14404

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

cell growth defective | somatic clone

arr²

increased cell death | somatic clone

arr²

memory defective | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

arr^GD121

neuroanatomy defective | larval stage (with arr²)

arr^k08131

neuroanatomy defective | larval stage (with arr^k08131)

arr²

planar polarity defective | cell non-autonomous | recessive | somatic clone

planar polarity defective | recessive | somatic clone

arr^G68

segment polarity phenotype | embryonic stage

arr²

some die during embryonic stage

arr¹

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

arr^GD2617

visible, with Scer\GAL4^Bx-MS1096

arr^UAS.cWb

visible, with Scer\GAL4^Mef2.PR

arr^GD2617

visible | recessive | somatic clone

arr²

visible | somatic clone

arr^αTub84B.PS

Phenotype manifest in

Allele

cuticle

denticle

arr^unspecified

denticle belt

arr¹

denticle belt | maternal effect

arr²

denticle field | embryonic stage

arr²

embryonic/first instar larval cuticle

arr^unspecified

embryonic/first instar larval cuticle | maternal effect

arr²

embryonic/larval cuticle | embryonic stage

arr²

embryonic/larval neuromuscular junction (with arr²)

arr^k08131

embryonic/larval neuromuscular junction (with arr^k08131)

arr²

embryonic epidermis

arr^unspecified

embryonic midgut constriction 2

eye

eye | somatic clone

eye disc | somatic clone

arr^63D

gastric caecum

head

interommatidial bristle | somatic clone

arr²

leg | somatic clone

arr^αTub84B.PS

macrochaeta

arr^L50A

ommatidium | ectopic | somatic clone

arr²

ommatidium | somatic clone

photoreceptor cell | somatic clone

arr^63D

presumptive embryonic/larval central nervous system

presumptive embryonic/larval peripheral nervous system

retina | ectopic

arr²

retina | somatic clone

arr²

secondary pigment cell | somatic clone

arr²

terminal bouton | larval stage (with arr²)

arr^k08131

terminal bouton | larval stage (with arr^k08131)

arr²

tertiary pigment cell | somatic clone

arr²

wing, with Scer\GAL4^Bx-MS1096

arr^UAS.cWb

wing, with Scer\GAL4^en-e16E

arr^dsRNA.UAS

wing, with Scer\GAL4^Mef2.PR

arr^GD2617

wing | somatic clone

wing disc | somatic clone

arr²

wing margin bristle | ectopic | somatic clone

arr^αTub84B.PS

wing margin bristle | somatic clone

arr²

wing sensillum | ectopic, with Scer\GAL4^Bx-MS1096

arr^UAS.cWb

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LRP6

13 of 15

Yes

Hsap\LRP5

12 of 15

Yes

Hsap\LRP4

4 of 15

Hsap\LRP5L

4 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

Yes

Hsap\LRP3

2 of 15

Yes

Hsap\LRP8

2 of 15

Hsap\LRP10

2 of 15

Yes

Hsap\LRP12

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\NID1

1 of 15

Hsap\NID2

1 of 15

Hsap\SORL1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Lrp6

13 of 15

Yes

Mmus\Lrp5

12 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

2 of 15

Yes

Mmus\Ldlr

2 of 15

Mmus\Lrp3

2 of 15

Yes

Mmus\Lrp8

2 of 15

Mmus\Lrp10

2 of 15

Yes

Mmus\Lrp12

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (17)

Rnor\Lrp6

10 of 13

Yes

Rnor\Lrp5

8 of 13

Yes

4 of 13

3 of 13

2 of 13

2 of 13

Yes

Rnor\Lrp8

2 of 13

Rnor\Lrp10

2 of 13

Yes

Rnor\Lrp12

2 of 13

Yes

Rnor\Vldlr

2 of 13

Rnor\Cd320

1 of 13

Rnor\Egf

1 of 13

Yes

Rnor\LOC100910275

1 of 13

Rnor\Lrp1b

1 of 13

Yes

Rnor\Lrp2

1 of 13

Rnor\Nid2

1 of 13

Rnor\Sspo

1 of 13

Xenopus tropicalis (Western clawed frog) (16)

Xtro\lrp6

7 of 12

Yes

Xtro\lrp5

6 of 12

Yes

Xtro\lrp4

3 of 12

Xtro\egf

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\lrp12

2 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Danio rerio (Zebrafish) (27)

Drer\lrp5

12 of 15

Yes

Drer\lrp6

5 of 15

Yes

3 of 15

3 of 15

3 of 15

2 of 15

Yes

Drer\ldlra

2 of 15

Drer\lrp2a

2 of 15

Drer\lrp3

2 of 15

Yes

Drer\lrp4

2 of 15

Drer\lrp8

2 of 15

Drer\lrp10

2 of 15

Yes

Drer\lrp12

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:dkey-258f14.3

1 of 15

Drer\sorl1

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\F14B4.1

2 of 15

Yes

Cele\lrp-1

2 of 15

Yes

Cele\lrp-2

2 of 15

Yes

Cele\clec-180

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900D7 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19223

Drosophila persimilis

Dper\GL17073

Drosophila willistoni

Dwil\GK15922

Drosophila virilis

Dvir\GJ19682

Drosophila mojavensis

Dmoj\GI21337

Drosophila grimshawi

Dgri\GH23152

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150097 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17014029

Glossina morsitans

Tsetse fly

Gmor\GMOY009327

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10644

Mayetiola destructor

Hessian fly

Mdes\Mdes007924

Mayetiola destructor

Hessian fly

Mdes\Mdes007917

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL009806

Anopheles darlingi

American malaria mosquito

Adar\ADAC000594

Anopheles gambiae

Malaria mosquito

Agam\AGAP011770

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000808

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00SP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA001048

Danaus plexippus

Monarch butterfly

Dple\DPOGS200714-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010093

Apis florea

Little honeybee

Aflo\3695197284

Apis mellifera

Western honey bee

Amel\GB51660

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15295

Bombus terrestris

Buff-tailed bumblebee

Bter\15208582

Linepithema humile

Argentine ant

Lhum\LH18031

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001908

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009194

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04525

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08151

Pediculus humanus

Human body louse

Phum\PHUM086410

Cimex lectularius

Bed bug

Clec\CLEC005797

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14170

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00RF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR009116

Ixodes scapularis

Black-legged tick

Isca\ISCW023971

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78305.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82476.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310287

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0178 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Lrp6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020325gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Lrp4

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022269

Ciona intestinalis

Vase tunicate

Cint\LOC100184434

Ciona intestinalis

Vase tunicate

Cint\lrp5/6

Gallus gallus

Domestic chicken

Ggal\LRP5

Gallus gallus

Domestic chicken

Ggal\LRP6

Gallus gallus

Domestic chicken

Ggal\LRP4

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

cue

2 of 10

LpR2

2 of 10

mgl

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Ndg

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

LRP6; LDL receptor related protein 6

model of coronary artery disease

IEA

(FlyBase, 2019-)

LRP5; LDL receptor related protein 5

model of osteoporosis

IEA

(FlyBase, 2019-)

model of osteoporosis-pseudoglioma syndrome

IEA

(FlyBase, 2019-)

model of Worth syndrome

IEA

(FlyBase, 2019-)

model of autosomal dominant osteopetrosis 1

IEA

(FlyBase, 2019-)

model of exudative vitreoretinopathy 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LRP6; LDL receptor related protein 6

13 of 15

603507

coronary artery disease

LRP5; LDL receptor related protein 5

12 of 15

603506

LRP4; LDL receptor related protein 4

4 of 15

604270

LRP5L; LDL receptor related protein 5 like

4 of 15

LRP1B; LDL receptor related protein 1B

3 of 15

608766

LRP1; LDL receptor related protein 1

3 of 15

107770

KERATOSIS PILARIS ATROPHICANS; KPA

keratosis pilaris atrophicans

LRP2; LDL receptor related protein 2

3 of 15

600073

DONNAI-BARROW SYNDROME

Donnai-Barrow syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

arr - Axn

two hybrid, pull down, western blot, anti tag coimmunoprecipitation

(Tacchelly-Benites et al., 2018, Tolwinski et al., 2003, Yamazaki and Yanagawa, 2003)

arr - CAP

pull down, western blot

(Yamazaki and Yanagawa, 2003)

arr - dsh

pull down, western blot

(Yamazaki and Yanagawa, 2003)

arr - wg

affinity technology, fluorescence microscopy, inferred by author

(Piddini et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

arr

suppressible

arr::fz2

(Tolwinski et al., 2003)

arr

suppressible

dsh

(Metcalfe et al., 2010, Wehrli et al., 2000)

arr

enhanceable

puc

(Giraldez and Cohen, 2003)

arr

suppressible

puc

(Giraldez and Cohen, 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nwk

suppressible

arr

(Rodal et al., 2011)

suppressible

arr

(Wehrli and Tomlinson, 1998)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68943

DroID - A comprehensive database of gene and protein interactions.

FBgn0000119

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44279

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Wnt-TCF Signaling Pathway Core Components -: The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Disassembly of the destruction complex and recruitment of AXIN to the membrane

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

50A9-50A11

Sequence location

2R:13,453,640..13,483,229 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50A9-50A11

Limits computationally determined from genome sequence between P{EP}Dp^EP358 and P{lacW}drk^k13809&P{EP}mip120^EP606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

50A9-50A10

(Avery, 2000.1.11, BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-72.3

(Comeron et al., 2012)

2-66

(Tearle and Nusslein-Volhard, 1987)

Left of (cM)

Right of (cM)

(Vaizel-Ohayon and Schejter, 1999)

Notes

Stocks and Reagents

Stocks (24)

Bloomington

31313

y¹ v¹; P{TRiP.JF01260}attP2

31473

y¹ v¹; P{TRiP.JF01261}attP2

53342

y¹ v¹; P{TRiP.HMC03571}attP40

37088

y¹ w^*; Mi{MIC}arr^MI03803/SM6a

37186

y¹ w^*; Mi{MIC}arr^MI03378/SM6a

43026

y¹ w^*; Mi{MIC}arr^MI05833/SM6a

665

y¹ w^67c23; P{lacW}arr^k08131/CyO

VDRC

v6707

w¹¹¹⁸; P{GD121}v6707

v6708

w¹¹¹⁸; P{GD121}v6708

v4818

w¹¹¹⁸; P{GD2617}v4818

v36286

w¹¹¹⁸; P{GD14404}v36286

v4819

w¹¹¹⁸; P{GD2617}v4819/CyO

More stocks available...

Genomic Clones (42)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (53)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP19005

Other clones

FI17867

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000119

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000119

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44279

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: LRP6 CG5912

(Bayraktaroglu, 2000.8.7)

Source for merge of: arr LRP6

(Wehrli et al., 2000)

Source for merge of: arr BEST:CK00539

(Bayraktaroglu, 2000.11.2)

Additional comments

FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970^e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arr^e00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970.

(Bloomington Drosophila Stock Center, 2004.11.6)

Other Comments

Reducing arr expression, specifically in adult mushroom bodies, impairs long-term memory expression without altering other temporally or mechanistically distinct forms of olfactory memory.

(Tan et al., 2013)

dsRNA made from templates generated with primers directed against this gene.

(Bartscherer et al., 2006)

wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells.

(Rives et al., 2006)

The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment.

(Piddini et al., 2005)

arr gene function is essential in cells receiving wg input and it acts upstream of dsh.

(Wehrli et al., 2000)

Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

(Kopczynski et al., 1998)

Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr^- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development.

(Li and Kaufman, 1996)

Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects.

(Li et al., 1995)

Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44279

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000119

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000119

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

arr_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5912

Flygut - An atlas of the Drosophila adult midgut

FBgn0000119

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

351787

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44279

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5912

modMine - A data warehouse for the modENCODE project

FBgn0000119

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A1Z9D7

Linkouts

BioGRID - A database of protein and genetic interactions.

68943

DroID - A comprehensive database of gene and protein interactions.

FBgn0000119

DRSC - Results frm RNAi screens

FBgn0000119

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000119

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5912-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000119

FlyMine - An integrated database for Drosophila genomics

FBgn0000119

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44279

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Disassembly of the destruction complex and recruitment of AXIN to the membrane

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

Arr

(Billmann et al., 2018, Waghmare and Page-McCaw, 2018, Wang et al., 2016, Jenny and Basler, 2014, Schilling et al., 2014, Mbodj et al., 2013, Serysheva et al., 2013, Zhang et al., 2013, Buechling et al., 2011, Mukai et al., 2010, Seto and Bellen, 2006, Zhang et al., 2006, Schweizer and Varmus, 2003)

BEST:CK00539

CG5912

(Ni et al., 2010.12.1, Perkins et al., 2009, Ni et al., 2008, Norga et al., 2003, Mirth and Akam, 2002, Wehrli, 2000.10.22, Wehrli, 2000.10.22)

CK00539

(Kopczynski et al., 1998)

CT15575

(Hynes and Zhao, 2000, Wehrli et al., 2000)

Dm Arr

(Konikoff et al., 2010)

Irp6

(Bartscherer et al., 2006)

LRP

(Jenny and Basler, 2014, Silver et al., 2007, Furlong, 2005, Bienz and Hamada, 2004)

LRP/Arr

(Fearon and Cadigan, 2005)

LRP5/6

(Moon et al., 2002, Nusse, 2001)

LRP6

(Avery, 2000.1.11)

arr

(Nye et al., 2020, Weiner et al., 2020, Li and Baker, 2019, Xu et al., 2019, Huang et al., 2018, Newcomb et al., 2018, Saito-Diaz et al., 2018, Kaur et al., 2017, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Moulton and Letsou, 2016, Tian et al., 2016, Gene Disruption Project members, 2015-, Mannava and Tolwinski, 2015, Sugie et al., 2015, Gersten et al., 2014, Kerr et al., 2014, Howlett et al., 2013, Serysheva et al., 2013, Webber et al., 2013, Kuroda et al., 2012, Bhattacharya and Baker, 2011, Giorgianni and Mann, 2011, Rodal et al., 2011, Toku et al., 2011, Vincent et al., 2011, Metcalfe et al., 2010, Blanco et al., 2009, Firth and Baker, 2009, Widmann and Dahmann, 2009, Chen et al., 2008, Estella et al., 2008, Miech et al., 2008, Ni et al., 2008, Baig-Lewis et al., 2007, DasGupta et al., 2007, Dietzl et al., 2007, Goodfellow et al., 2007, Koizumi et al., 2007, Silver et al., 2007, Zecca and Struhl, 2007, Zirin and Mann, 2007, Bartscherer et al., 2006, Lim and Tomlinson, 2006, Ma et al., 2006, DasGupta et al., 2005, Furlong, 2005, Povelones and Nusse, 2005, Giraldez and Cohen, 2003)

l(2)k08131

(BDGP Project Members, 1994-1999)

Name Synonyms

Dm Arrow

(Konikoff et al., 2010)

LDL-related protein 6

(Avery, 2000.1.11)

LDLR-like

(Hynes and Zhao, 2000)

LRP5/6/Arrow

(Heeg-Truesdell, 2006)

Secondary FlyBase IDs

FBgn0022055
FBgn0025707
FBgn0033841
FBgn0040307

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (244)

The following external sites may use different assemblies or annotations than FlyBase.

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