A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\arr

General Information
SymbolDmel\arrSpeciesD. melanogaster
NamearrowAnnotation symbolCG5912
Feature typeprotein_coding_geneFlyBase IDFBgn0000119
Gene Model StatusCurrent Stock availability 14 publicly available
Also Known AsLRP, LRP5/6, CT15575
Genomic Location
Chromosome (arm)2RRecombination map2-66
Cytogenetic map50A9-50A11Sequence location2R:9,341,159..9,370,723 [-]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene arrow is referred to in FlyBase by the symbol Dmel\arr (CG5912, FBgn0000119). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-activated receptor activity; Wnt-protein binding. There is experimental evidence that it is involved in the biological process: canonical Wnt receptor signaling pathway; nervous system development; regulation of compound eye pigmentation; Wnt receptor signaling pathway; protein targeting to lysosome; compound eye morphogenesis. 42 alleles are reported. The phenotypes of these alleles are annotated with: organ system; cuticle; organ system subdivision; non-connected developing system; presumptive embryonic/larval nervous system; multicellular structure; integumentary system; cuticular specialization; sensillum; external compound sense organ; midgut constriction; acellular anatomical structure; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Epidermal growth factor-like; LDLR class B repeat; Low density lipoprotein receptor-related protein, 5/6; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1634211_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of arr. Gene sequence location is 2R:9341159..9370723.

External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
arr: arrow
Embryonic lethal. Additional denticle bands anterior and posterior to normal denticle bands, especially in ventral midline. Strongest at 18.
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Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01
Insertions
Alleles
References
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
50A9-50A11  
Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
50A9-50A10  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\arr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0087666 FBtr0309887 FBtr0309886 FBtr0306064 FBtr0087702 FBtr0087701 FBpp0086786 FBpp0301620 FBpp0301621 FBpp0297206 FBpp0086821 FBpp0086820 FBti0067434 FBti0051161 FBti0145408 FBti0052453 FBti0145532 FBti0033286 FBti0041353
Comments on Gene Model
DGC clone LD10754 appears problematic: incomplete CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0087702
  5999
  1678
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
arr-PA  
FBpp0086821  
187.5  
1678  
7.00  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view cbs-RA cbs-RC cbs-RB CG43192-RA arr-RA cbc-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0000119


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0000119
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0000119 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1612)
embryo 02-04hr
 (2501)
embryo 04-06hr
 (3334)
embryo 06-08hr
 (2596)
embryo 08-10hr
 (2431)
embryo 10-12hr
 (2086)
embryo 12-14hr
 (1772)
embryo 14-16hr
 (1419)
embryo 16-18hr
 (1219)
embryo 18-20hr
 (896)
embryo 20-22hr
 (1119)
embryo 22-24hr
 (1063)
larva L1
 (634)
larva L2
 (378)
larva L3 12hr old
 (484)
larva L3 puffstage 1-2
 (663)
larva L3 puffstage 3-6
 (1267)
larva L3 puffstage 7-9
 (1505)
white prepupae new
 (1722)
white prepupae 12hr
 (1663)
white prepupae 24hr
 (2662)
pupae 2d postWPP
 (1187)
pupae 3d postWPP
 (694)
pupae 4d postWPP
 (549)
adult male 01day
 (727)
adult male 05day
 (740)
adult male 30day
 (671)
adult female 01day
 (614)
adult female 05day
 (649)
adult female 30day
 (683)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1612)
embryo 02-04hr
 (2501)
embryo 04-06hr
 (3334)
embryo 06-08hr
 (2596)
embryo 08-10hr
 (2431)
embryo 10-12hr
 (2086)
embryo 12-14hr
 (1772)
embryo 14-16hr
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 1505
white prepupae new
 (1722)
white prepupae 12hr
 (1663)
white prepupae 24hr
 (2662)
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0000119 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (1612)
embryo 02-04hr
 (2501)
embryo 04-06hr
 (3334)
embryo 06-08hr
 (2596)
embryo 08-10hr
 (2431)
embryo 10-12hr
 (2086)
embryo 12-14hr
 (1772)
embryo 14-16hr
 (1419)
embryo 16-18hr
 (1219)
embryo 18-20hr
 (896)
embryo 20-22hr
 (1119)
embryo 22-24hr
 (1063)
larva L1
 (634)
larva L2
 (378)
larva L3 12hr old
 (484)
larva L3 puffstage 1-2
 (663)
larva L3 puffstage 3-6
 (1267)
larva L3 puffstage 7-9
 (1505)
white prepupae new
 (1722)
white prepupae 12hr
 (1663)
white prepupae 24hr
 (2662)
pupae 2d postWPP
 (1187)
pupae 3d postWPP
 (694)
pupae 4d postWPP
 (549)
adult male 01day
 (727)
adult male 05day
 (740)
adult male 30day
 (671)
adult female 01day
 (614)
adult female 05day
 (649)
adult female 30day
 (683)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 1612
embryo 02-04hr
 (2501)
embryo 04-06hr
 (3334)
embryo 06-08hr
 (2596)
embryo 08-10hr
 2431
embryo 10-12hr
 2086
embryo 12-14hr
 1772
embryo 14-16hr
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 1505
white prepupae new
 1722
white prepupae 12hr
 1663
white prepupae 24hr
 (2662)
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1612
embryo 02-04hr
 
 2501
embryo 04-06hr
 
 3334
embryo 06-08hr
 
 2596
embryo 08-10hr
 
 2431
embryo 10-12hr
 
 2086
embryo 12-14hr
 
 1772
embryo 14-16hr
 
 1419
embryo 16-18hr
 
 1219
embryo 18-20hr
 
 896
embryo 20-22hr
 
 1119
embryo 22-24hr
 
 1063
larva L1
 
 634
larva L2
 
 378
larva L3 12hr old
 
 484
larva L3 puffstage 1-2
 
 663
larva L3 puffstage 3-6
 
 1267
larva L3 puffstage 7-9
 
 1505
white prepupae new
 
 1722
white prepupae 12hr
 
 1663
white prepupae 24hr
 
 2662
pupae 2d postWPP
 
 1187
pupae 3d postWPP
 
 694
pupae 4d postWPP
 
 549
adult male 01day
 
 727
adult male 05day
 
 740
adult male 30day
 
 671
adult female 01day
 
 614
adult female 05day
 
 649
adult female 30day
 
 683
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0000119


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0000119
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0000119 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0000119 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 260.675
Larval Midgut
 
 69.2
Larval Hindgut
 
 125.5
Larval Malpighian Tubules
 
 140.2
Larval Fat Body
 
 104.5
Larval Salivary Gland
 
 297.2
Larval Trachea
 
 206.35
Larval Carcass
 
 171.025
Adult Head
 
 90.2
Adult Eye
 
 85.825
Adult Brain
 
 112.5
Adult Thoracic-Abdominal Ganglion
 
 78.5
Adult Crop
 
 121.6
Adult Midgut
 
 79.9
Adult Hindgut
 
 75.2
Adult Malpighian Tubules
 
 85.1
Adult Fat Body
 
 104.8
Adult Salivary Gland
 
 291.6
Adult Heart
 
 66.6
Adult VirginFemale Spermatheca
 
 161.9
Adult InseminatedFemale Spermatheca
 
 158.5
Adult Ovary
 
 207.4
Adult Testis
 
 30.7
Adult Male Accessory Gland
 
 64.9
Adult Carcass
 
 38.5
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 90.2
 
NA 
Eye
 
 85.825
 
NA 
Brain
 
 112.5
 
260.675 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 78.5
 
NA 
Crop
 
 121.6
 
69.2 
Midgut
 
 79.9
 
125.5 
Hindgut
 
 75.2
 
140.2 
Malpighian Tubules
 
 85.1
 
104.5 
Fat Body
 
 104.8
 
297.2 
Salivary Gland
 
 291.6
 
NA 
Heart
 
 66.6
 
206.35 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 161.9
 
NA 
InseminatedFemale Spermatheca
 
 158.5
 
NA 
Ovary
 
 207.4
 
NA 
Testis
 
 30.7
 
NA 
Male Accessory Gland
 
 64.9
 
171.025 
Carcass
 
 38.5

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 18 )
For All Classical Alleles Show

Allele of arrClassMutagenStocksKnown lesion
arr22 Yes
arrEY044532 --
arrf03320
1 --
arrf056061 --
arrk081311 --
arr12-1loss of function allele0 --
arr1340 Yes
arr16-10 Yes
arr10 --
arr4loss of function allele0 --
arr63D0 --
arrG68
0 --
arrG6
0 --
arrL10 Yes
arrL50A0 Yes
arrMI03378
0 --
arrMI03803
0 --
arrunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show

Allele of arrClassMutagenStocksKnown lesion
arrGD1212 Yes
arrGD26172 Yes
arrGD144041 Yes
arrJF012601 Yes
arrJF012611 Yes
arr1185-13930 Yes
arra.1185-13930 Yes
arrAct5C.T:Ivir\HA10 Yes
arrC.Scer\UAS.T:Myr1,T:Ivir\HA10 Yes
arrdsRNA.cGa0 Yes
arrdsRNA.cMa0 --
arrdsRNA.cTa0 Yes
arrdsRNA.Scer\FRT.Scer\UAS0 Yes
arrdsRNA.Scer\UAS0 Yes
arrIntra.T:Myr1,T:Zzzz\FLAG0 Yes
arrScer\FRT.Scer\UAS.T:Ivir\HA10 Yes
arrScer\FRT.Scer\UAS0 Yes
arrScer\UAS.cPa.T:Ivir\HA10 Yes
arrScer\UAS.cRa.T:Ivir\HA10 Yes
arrScer\UAS.cWa0 Yes
arrScer\UAS.cWb0 Yes
arrScer\UAS.T:Ivir\HA10 --
arrScer\UAS.T:wg,T:Avic\GFP,T:Hsap\MYC0 Yes
arrΔC.Scer\UAS.T:Ivir\HA10 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap
hide Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
hide Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term
References
inferred from physical interaction with wg
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component
CV term
References
colocalizes_with
early endosome
inferred from direct assay
colocalizes_with
late endosome
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term
References
inferred from sequence or structural similarity with mouse Lrp5 AND inferred from sequence or structural similarity with mouse Lrp6
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
arr allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 14 )
Bloomington
Harvard
Kyoto
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 55 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: arr BEST:CK00539
Source for merge of: arr LRP6
Source for merge of: LRP6 CG5912
Additional comments
FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970.
hide Other Comments
dsRNA made from templates generated with primers directed against this gene.
wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells.
The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment.
arr gene function is essential in cells receiving wg input and it acts upstream of dsh.
Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development.
Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects.
Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym
BEST:CK00539
 
Name Synonym
LDL-related protein 6
LRP5/6/Arrow
Secondary FlyBase IDs
  • FBgn0022055
  • FBgn0025707
  • FBgn0033841
  • FBgn0040307
hide References ( 161 )
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List References by type
hide Recent research papers ( 4 )
Rodal et al., 2011, J. Cell Biol. 193(1): 201--217
A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353]
Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312
Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842]
Metcalfe et al., 2010, J. Cell Sci. 123(9): 1588--1599
Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization. [FBrf0210630]
Mukai et al., 2010, EMBO J. 29(13): 2114--2125
Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. [FBrf0211204]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010