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Gene Dmel\arr

General Information
Symbol	Dmel\arr	Species	D. melanogaster
Name	arrow	Annotation symbol	CG5912
Feature type	protein_coding_gene	FlyBase ID	FBgn0000119
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	LRP, LRP5/6, CT15575
Genomic Location
Chromosome (arm)	2R	Recombination map	2-66
Cytogenetic map	50A9-50A11	Sequence location	2R:9,341,159..9,370,723 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene arrow is referred to in FlyBase by the symbol Dmel\arr (CG5912, FBgn0000119). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-activated receptor activity; Wnt-protein binding. There is experimental evidence that it is involved in the biological process: canonical Wnt receptor signaling pathway; nervous system development; regulation of compound eye pigmentation; Wnt receptor signaling pathway; protein targeting to lysosome; compound eye morphogenesis. 42 alleles are reported. The phenotypes of these alleles are annotated with: organ system; cuticle; organ system subdivision; non-connected developing system; presumptive embryonic/larval nervous system; multicellular structure; integumentary system; cuticular specialization; sensillum; external compound sense organ; midgut constriction; acellular anatomical structure; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Epidermal growth factor-like; LDLR class B repeat; Low density lipoprotein receptor-related protein, 5/6; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1634211_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of arr. Gene sequence location is 2R:9341159..9370723.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	arr: arrow Embryonic lethal. Additional denticle bands anterior and posterior to normal denticle bands, especially in ventral midline. Strongest at 18.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Insertions Mi{MIC}arr[MI03803] Mi{MIC}arr[MI03378] Alleles arr[MI03803] arr[MI03378] References Bellen, 2011.11.10, set958.xml Bellen, 2011.10.25, set956.xml Sequence features BKN21133 HFA07451
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A9-50A11   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50A9-50A10     (Avery, 2000.1.11) 50A9-50A10     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-66 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)	cnn (Vaizel-Ohayon and Schejter, 1999)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\arr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD10754 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) arr-RA FBtr0087702  NM_079998   5999   1678
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein arr-PA   FBpp0086821   187.5   1678   7.00     NP_524737   AAF58373
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • LDLR class B repeat (IPR000033) Epidermal growth factor-like (IPR006210) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Six-bladed beta-propeller, TolB-like (IPR011042) Low density lipoprotein receptor-related protein, 5/6 (IPR017049) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140895   AA391829   AE013599 AAF58373   AF223365 AAF28358   AW942154   AY005815 AAF91072   BT015250 AAT94479   CO184554   CO187827   CO189633   CO195373   CO271371   CO275450   CO280914   CO293318   CO300657   CO300970   CO302732   CO306183   CO316290   CO321555   CO327002   CO339653   CZ488207   EC064974   EC072159   EC078214   EC195195   EC197880   EC203513   EC210756   EC210903   EC211338   EC211801   EC212558   EC220424   EC227168   EC229859   EC246092   EC257893   GH943037   GH944019   GH945075   GH947043   GH947662   GH948865   GH950939   GH954986   GH955405   GH962070   GH962654   GH962820   GH964166   GH966493   GH969165   GH975723   GH979678   GH982792   GH982894   GH983978
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6AWJ8 Q95V09 Q9NHE9 A1Z9D7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000119    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000119 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000119 expression level Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1612) embryo 02-04hr  (2501) embryo 04-06hr  (3334) embryo 06-08hr  (2596) embryo 08-10hr  (2431) embryo 10-12hr  (2086) embryo 12-14hr  (1772) embryo 14-16hr  (1419) embryo 16-18hr  (1219) embryo 18-20hr  (896) embryo 20-22hr  (1119) embryo 22-24hr  (1063) larva L1  (634) larva L2  (378) larva L3 12hr old  (484) larva L3 puffstage 1-2  (663) larva L3 puffstage 3-6  (1267) larva L3 puffstage 7-9  (1505) white prepupae new  (1722) white prepupae 12hr  (1663) white prepupae 24hr  (2662) pupae 2d postWPP  (1187) pupae 3d postWPP  (694) pupae 4d postWPP  (549) adult male 01day  (727) adult male 05day  (740) adult male 30day  (671) adult female 01day  (614) adult female 05day  (649) adult female 30day  (683) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1612) embryo 02-04hr  (2501) embryo 04-06hr  (3334) embryo 06-08hr  (2596) embryo 08-10hr  (2431) embryo 10-12hr  (2086) embryo 12-14hr  (1772) embryo 14-16hr  1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9  1505 white prepupae new  (1722) white prepupae 12hr  (1663) white prepupae 24hr  (2662) pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000119 expression level Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1612) embryo 02-04hr  (2501) embryo 04-06hr  (3334) embryo 06-08hr  (2596) embryo 08-10hr  (2431) embryo 10-12hr  (2086) embryo 12-14hr  (1772) embryo 14-16hr  (1419) embryo 16-18hr  (1219) embryo 18-20hr  (896) embryo 20-22hr  (1119) embryo 22-24hr  (1063) larva L1  (634) larva L2  (378) larva L3 12hr old  (484) larva L3 puffstage 1-2  (663) larva L3 puffstage 3-6  (1267) larva L3 puffstage 7-9  (1505) white prepupae new  (1722) white prepupae 12hr  (1663) white prepupae 24hr  (2662) pupae 2d postWPP  (1187) pupae 3d postWPP  (694) pupae 4d postWPP  (549) adult male 01day  (727) adult male 05day  (740) adult male 30day  (671) adult female 01day  (614) adult female 05day  (649) adult female 30day  (683) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1612 embryo 02-04hr  (2501) embryo 04-06hr  (3334) embryo 06-08hr  (2596) embryo 08-10hr  2431 embryo 10-12hr  2086 embryo 12-14hr  1772 embryo 14-16hr  1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9  1505 white prepupae new  1722 white prepupae 12hr  1663 white prepupae 24hr  (2662) pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1612 embryo 02-04hr    2501 embryo 04-06hr    3334 embryo 06-08hr    2596 embryo 08-10hr    2431 embryo 10-12hr    2086 embryo 12-14hr    1772 embryo 14-16hr    1419 embryo 16-18hr    1219 embryo 18-20hr    896 embryo 20-22hr    1119 embryo 22-24hr    1063 larva L1    634 larva L2    378 larva L3 12hr old    484 larva L3 puffstage 1-2    663 larva L3 puffstage 3-6    1267 larva L3 puffstage 7-9    1505 white prepupae new    1722 white prepupae 12hr    1663 white prepupae 24hr    2662 pupae 2d postWPP    1187 pupae 3d postWPP    694 pupae 4d postWPP    549 adult male 01day    727 adult male 05day    740 adult male 30day    671 adult female 01day    614 adult female 05day    649 adult female 30day    683 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000119    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000119 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000119 expression level Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000119 expression level Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    90.2   NA  Eye    85.825   NA  Brain    112.5   260.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    78.5   NA  Crop    121.6   69.2  Midgut    79.9   125.5  Hindgut    75.2   140.2  Malpighian Tubules    85.1   104.5  Fat Body    104.8   297.2  Salivary Gland    291.6   NA  Heart    66.6   206.35  Trachea    NA   NA  VirginFemale Spermatheca    161.9   NA  InseminatedFemale Spermatheca    158.5   NA  Ovary    207.4   NA  Testis    30.7   NA  Male Accessory Gland    64.9   171.025  Carcass    38.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000119 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5912-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for arr Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | partially | recessive | somatic clone arrunspecified lethal, with Scer\GAL4Act5C.PU arrGD121 arrGD2617 arrGD14404 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH arrGD121 arrGD2617 arrGD14404 lethal | embryonic stage arr1 lethal | embryonic stage | recessive arr4 arr12-1 arr16-1 arrL1 arrunspecified lethal | recessive arrk08131 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 arrGD2617 viable, with Scer\GAL4pnr-MD237 arrGD121 arrGD14404 Other Phenotypes Allele cell growth defective | somatic clone arr2 increased cell death | somatic clone arr2 planar polarity defective | cell non-autonomous | recessive | somatic clone arr2 arrG6 planar polarity defective | recessive | somatic clone arrG68 visible, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb visible | recessive | somatic clone arr2 Phenotype manifest in Allele cuticle arr12-1 arr16-1 arr4 arrL1 denticle arrunspecified denticle belt arr1 arrdsRNA.cTa embryonic/first instar larval cuticle arrdsRNA.cTa arrunspecified embryonic epidermis arrunspecified eye arr12-1 arr16-1 arr4 arrL1 eye | somatic clone arr2 arr63D eye disc | somatic clone arr63D gastric caecum arr12-1 arr16-1 arr4 arrL1 head arr12-1 arr16-1 arr4 arrL1 interommatidial bristle | somatic clone arr2 macrochaeta arrL50A midgut constriction 2 arr12-1 arr16-1 arr4 arrL1 ommatidium | ectopic | somatic clone arr2 ommatidium | somatic clone arr2 arrG6 arrG68 photoreceptor cell | somatic clone arr63D presumptive embryonic/larval central nervous system arr12-1 arr16-1 arr4 arrL1 presumptive embryonic/larval peripheral nervous system arr12-1 arr16-1 arr4 arrL1 retina | ectopic arr2 retina | somatic clone arr2 secondary pigment cell | somatic clone arr2 tertiary pigment cell | somatic clone arr2 wing, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb wing, with Scer\GAL4en-e16E arrdsRNA.Scer\UAS wing | somatic clone arr2 wing disc | somatic clone arr2 wing margin bristle | somatic clone arr2 wing sensillum | ectopic, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of arr Class Mutagen Stocks Known lesion arr2 ethyl methanesulfonate 2 Yes arrEY04453 P-element activity 2 -- arrf03320 1 -- arrf05606 piggyBac transposase 1 -- arrk08131 P-element activity 1 -- arr12-1 loss of function allele ethyl methanesulfonate 0 -- arr134 P-element activity 0 Yes arr16-1 ethyl methanesulfonate 0 Yes arr1 ethyl methanesulfonate 0 -- arr4 loss of function allele ethyl methanesulfonate 0 -- arr63D ethyl methanesulfonate 0 -- arrG68 0 -- arrG6 0 -- arrL1 ethyl methanesulfonate 0 Yes arrL50A P-element activity 0 Yes arrMI03378 0 -- arrMI03803 0 -- arrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of arr Class Mutagen Stocks Known lesion arrGD121 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes arrGD2617 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes arrGD14404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arrJF01260 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arrJF01261 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arr1185-1393 in vitro construct - RNAi 0 Yes arra.1185-1393 in vitro construct - RNAi 0 Yes arrAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes arrC.Scer\UAS.T:Myr1,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrdsRNA.cGa in vitro construct - RNAi 0 Yes arrdsRNA.cMa in vitro construct - RNAi 0 -- arrdsRNA.cTa in vitro construct - RNAi 0 Yes arrdsRNA.Scer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes arrdsRNA.Scer\UAS FLPase in vitro construct - RNAi 0 Yes arrIntra.T:Myr1,T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes arrScer\FRT.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrScer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes arrScer\UAS.cPa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrScer\UAS.cRa.T:Ivir\HA1 FLPase 0 Yes arrScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes arrScer\UAS.cWb FLPase 0 Yes arrScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 -- arrScer\UAS.T:wg,T:Avic\GFP,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrΔC.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)8-104 (Vaizel-Ohayon and Schejter, 1999) Df(2R)CX1 (Baker, 2005.1.6, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)vg-B (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD121} NA P{GD2617} NA P{GD14404} NA P{TRiP.JF01260} NA P{TRiP.JF01261} NA P{UAS(FRT.T:Hcri\RFP)arr.dsRNA} NA P{UAS(FRT.w+)arr.HA} NA P{UAS(-FRT)arr.HA} NA P{UAS-arr.flu} NA P{UAS-arr.FRT.Wb} NA P{UAS-arr.GFP} NA P{UAS-arr.HA} NA P{UAS-arr.Wa} NA P{UAS-arr.Wb} NA P{UAS-arr.ΔC.HA} NA characterization construct P{UAS-arr.intra.myr.FALFG} NA P{UAS-fz2:arr.intra.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}arrEY04453 NA miscellaneous insertions Mi{MIC}arrMI03378 NA Mi{MIC}arrMI03803 NA P{?unk}arr134 NA PBac{WH}arrf03320 NA PBac{WH}arrf05606 NA insertion of enhancer trap P{lacW}arrk08131 No P{lArB}arrL50A No
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
Wnt-activated receptor activity inferred from direct assay (Rives et al., 2006) Wnt-protein binding inferred from physical interaction with wg (Piddini et al., 2005)
Biological Process
CV term Evidence References
canonical Wnt receptor signaling pathway inferred from mutant phenotype (Povelones and Nusse, 2005) compound eye morphogenesis inferred from mutant phenotype (Tomlinson, 2003) nervous system development inferred from mutant phenotype (Koizumi et al., 2007) protein targeting to lysosome inferred from mutant phenotype (Piddini et al., 2005) regulation of compound eye pigmentation inferred from mutant phenotype (Lim and Tomlinson, 2006) Wnt receptor signaling pathway inferred from mutant phenotype (Wehrli et al., 2000)
Cellular Component
CV term Evidence References
colocalizes_with early endosome inferred from direct assay (Rives et al., 2006) colocalizes_with late endosome inferred from direct assay (Rives et al., 2006) plasma membrane inferred from direct assay (Rives et al., 2006)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
low-density lipoprotein receptor activity inferred from sequence or structural similarity with mouse Lrp5 AND inferred from sequence or structural similarity with mouse Lrp6 (Wehrli et al., 2000)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions arr allele Gene References arr2 arr::fz2 (Tolwinski et al., 2003) wg (Wehrli and Tomlinson, 1998) arrdsRNA.cTa Axn (Tolwinski et al., 2003) arrunspecified dsh (Wehrli et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68943 DroID - A comprehensive database of gene and protein interactions. • FBgn0000119 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44279
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11183 Dere\GG22489 Dgri\GH23152 Dmoj\GI21337 Dper\GL17073 Dpse\GA19223 Dsec\GM20276 Dvir\GJ19682 Dwil\GK15922 Dyak\GE13360
Curated drosophilid orthologs	Dpse\GA19223
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009806-PA Aedes aegypti (mosquito) AGAP011770-PA Anopheles gambiae (mosquito) XP_001120228.1 Apis mellifera (honey bee) XP_001950234.1 Acyrthosiphon pisum (pea aphid) 123121 Branchiostoma floridae (lancelet) 219787 Branchiostoma floridae (lancelet) BGIBMGA001048-PA Bombyx mori (silk worm) ENSBTAP00000007756 Bos taurus (bovine) ENSCAFP00000019674 Canis familiaris (dog) ENSCINP00000017833 Ciona intestinalis (sea squirt) CPIJ000808 Culex pipens (mosquito) ENSCPOP00000011935 Cavia porcellus (guinea pig) 160497 Capitella spl (polychaete worm) 310287 Daphnia pulex (daphnia) ENSDARP00000006398 Danio rerio (zebra fish) ENSECAP00000005754 Equus caballus (horse) ENSGACP00000000775 Gymnopilus aculeatus (mushroom) ENSGALP00000018818 Gallus gallus (chicken) 170722 Hypsipyla robusta (cedar shoot borer) ENSP00000261349 Homo sapiens (human) 171958 Lottia gigantea (owl limpet) ENSMODP00000035641 Monodelphis domestica (gray opossum) ENSMMUP00000040191 Macaca mulatta (rhesus monkey) ENSMUSP00000032322 Mus musculus (house mouse) 158520 Nematostella vectensis (starlet anemone) XP_001603043.1 Nasonia vitripennis (wasp) ENSOANP00000010961 Ornithorynchus anatinus (platypus) ENSORLP00000023196 Oryzias latipes (japanese killifish) PHUM006587-PA Pediculus humanus (human body louse) ENSPTRP00000008035 Pan troglodytes (chimpanzee) ENSRNOP00000008486 Rattus norvegicus (norway rat) XP_001202408.1 Strongylocentrotus purpuratus (purple sea urchin) 19424 Trichoplax adhaerens (metazoa) XP_975483.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005946 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006122 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022100 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14309 LH18031 ISCW023971 FBgn0231039 FBgn0217924 FBgn0206824 FBgn0197040 FBgn0175159 JGI_V11_310287 FBgn0079220 FBgn0154677 FBgn0144067 FBgn0130609 FBgn0114660 FBgn0088223 CPIJ000808 BGIBMGA001048 ACYPI005033 GB11226 AGAP011770 AAEL009806 PB22758 PHUM086410 GLEAN_08151
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	31313 y1 v1; P{TRiP.JF01260}attP2 31473 y1 v1; P{TRiP.JF01261}attP2 3087 cn1 arr2 bw1 sp1/CyO 665 y1 w67c23; P{lacW}arrk08131/CyO
Harvard	- PBac{WH}arrf03320 - PBac{WH}arrf05606
Kyoto	106831 cn1 arr2 bw1 sp1/CyO
VDRC	v6707 w1118; P{GD121}v6707 v6708 w1118; P{GD121}v6708 v4818 w1118; P{GD2617}v4818 v36286 w1118; P{GD14404}v36286 v4819 w1118; P{GD2617}v4819/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR36J03 BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP19005
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	8350 14737 42161 44443 54550 57825 61130 73346 103870 147288 165836 166903 214577.23 CK01.40B.F11 CK01.55C.F10 CK01.168B.D3 CK00539 EC28251 EC40220 EK033818 EK044755 EK103214 EK117620 EK155452 EK178924 EK179813 EK184808 EK185922 EK202554 EK250447 EK264409 EP02446 EP05433 LD10754 RP004098045 RP004105061 RP004167473 RP004193627 RP004203400 RP004205980 RP004214037 RP004216426 RP004216990 RP004233566 RP004246707 RP004247795 RP004255096 RP004336300 RP004445429 RP004478996 RP004505470 RP004521037 RP004523639 RP004528466
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44279
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: arr BEST:CK00539 (Bayraktaroglu, 2000.11.2) Source for merge of: arr LRP6 (Wehrli et al., 2000) Source for merge of: LRP6 CG5912 (Bayraktaroglu, 2000.8.7)
Additional comments	FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Bartscherer et al., 2006) wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells. (Rives et al., 2006) The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment. (Piddini et al., 2005) arr gene function is essential in cells receiving wg input and it acts upstream of dsh. (Wehrli et al., 2000) Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998) Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development. (Li and Kaufman, 1996) Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects. (Li et al., 1995) Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079998 RefSeq (Proteins) • NP_524737 DDBJ / EMBL / GenBank • AA140895 AA391829 AAF28358 AAF58373 AAF91072 AAT94479 AF223365 AW942154 AY005815 BT015250 CZ488207 Entrez Gene - A searchable database of RefSeq genes. • 44279 UniProtKB/TrEMBL • A1Z9D7 Q6AWJ8 Q9NHE9 Q95V09
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • LDLR class B repeat (IPR000033) Epidermal growth factor-like (IPR006210) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Six-bladed beta-propeller, TolB-like (IPR011042) Low density lipoprotein receptor-related protein, 5/6 (IPR017049) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68943 DroID - A comprehensive database of gene and protein interactions. • FBgn0000119 DRSC - Results from RNAi screens. • FBgn0000119 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000119 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5912-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000119 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 351787 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44279 InParanoid A subset of ortholog calls from InParanoid. • AAEL009806-PA Aedes aegypti (mosquito) AGAP011770-PA Anopheles gambiae (mosquito) XP_001120228.1 Apis mellifera (honey bee) XP_001950234.1 Acyrthosiphon pisum (pea aphid) 123121 Branchiostoma floridae (lancelet) 219787 Branchiostoma floridae (lancelet) BGIBMGA001048-PA Bombyx mori (silk worm) ENSBTAP00000007756 Bos taurus (bovine) ENSCAFP00000019674 Canis familiaris (dog) ENSCINP00000017833 Ciona intestinalis (sea squirt) CPIJ000808 Culex pipens (mosquito) ENSCPOP00000011935 Cavia porcellus (guinea pig) 160497 Capitella spl (polychaete worm) 310287 Daphnia pulex (daphnia) ENSDARP00000006398 Danio rerio (zebra fish) ENSECAP00000005754 Equus caballus (horse) ENSGACP00000000775 Gymnopilus aculeatus (mushroom) ENSGALP00000018818 Gallus gallus (chicken) 170722 Hypsipyla robusta (cedar shoot borer) ENSP00000261349 Homo sapiens (human) 171958 Lottia gigantea (owl limpet) ENSMODP00000035641 Monodelphis domestica (gray opossum) ENSMMUP00000040191 Macaca mulatta (rhesus monkey) ENSMUSP00000032322 Mus musculus (house mouse) 158520 Nematostella vectensis (starlet anemone) XP_001603043.1 Nasonia vitripennis (wasp) ENSOANP00000010961 Ornithorynchus anatinus (platypus) ENSORLP00000023196 Oryzias latipes (japanese killifish) PHUM006587-PA Pediculus humanus (human body louse) ENSPTRP00000008035 Pan troglodytes (chimpanzee) ENSRNOP00000008486 Rattus norvegicus (norway rat) XP_001202408.1 Strongylocentrotus purpuratus (purple sea urchin) 19424 Trichoplax adhaerens (metazoa) XP_975483.1 Tribolium castaneum (red flour beetle) ENSTNIP00000005946 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000006122 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022100 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/arrow1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44279 modMine - Data generated by the modENCODE project. • FBgn0000119 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14309 LH18031 ISCW023971 FBgn0231039 FBgn0217924 FBgn0206824 FBgn0197040 FBgn0175159 JGI_V11_310287 FBgn0079220 FBgn0154677 FBgn0144067 FBgn0130609 FBgn0114660 FBgn0088223 CPIJ000808 BGIBMGA001048 ACYPI005033 GB11226 AGAP011770 AAEL009806 PB22758 PHUM086410 GLEAN_08151
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	arr (DasGupta et al., 2005, Lim and Tomlinson, 2006, Giraldez and Cohen, 2003, Furlong, 2005, Bartscherer et al., 2006, Ma et al., 2006, Dietzl et al., 2007, Koizumi et al., 2007, Zecca and Struhl, 2007, Goodfellow et al., 2007, Estella et al., 2008, Baig-Lewis et al., 2007, Miech et al., 2008, Ni et al., 2008, Firth and Baker, 2009, Zirin and Mann, 2007, Blanco et al., 2009, Widmann and Dahmann, 2009, DasGupta et al., 2007, Povelones and Nusse, 2005, Silver et al., 2007, Rodal et al., 2011) Arr (Zhang et al., 2006, Seto and Bellen, 2006, Schweizer and Varmus, 2003, Mukai et al., 2010) BEST:CK00539   CG5912 (Norga et al., 2003, Mirth and Akam, 2002, Wehrli, 2000.10.22, Wehrli, 2000.10.22, Ni et al., 2008) CK00539 (Kopczynski et al., 1998) CT15575 (Hynes and Zhao, 2000, Wehrli et al., 2000) Dm Arr (Konikoff et al., 2010) Irp6 (Bartscherer et al., 2006) l(2)k08131 (BDGP Project Members, 1994-1999, ) LRP (Bienz and Hamada, 2004, Furlong, 2005, Silver et al., 2007) LRP5/6 (Moon et al., 2002, Nusse, 2001) LRP6 (Avery, 2000.1.11, ) LRP/Arr (Fearon and Cadigan, 2005)
Name Synonym	Arrow (Wehrli and Baig-Lewis, 2006, Rives et al., 2006, Clevers, 2006, Tountas and Fortini, 2007, Zhang et al., 2006, Seto and Bellen, 2006, Wilson and Chuang, 2006, Marques, 2005, Baig-Lewis et al., 2007, Schweizer and Varmus, 2003, Port et al., 2008, Khaliullina et al., 2009) arrow (Schlesinger and Shilo, 2005, Stadeli, 2006, Ma et al., 2006, Herranz et al., 2008, Goodfellow et al., 2007, Estella et al., 2008, Zirin and Mann, 2007, Chiang et al., 2009, Blanco et al., 2009, Soukup et al., 2009, Davidson et al., 2009, Widmann and Dahmann, 2009, Povelones and Nusse, 2005, Metcalfe et al., 2010, Silver et al., 2007, Rodal et al., 2011) Dm Arrow (Konikoff et al., 2010) LDL-related protein 6 (Avery, 2000.1.11) LDLR-like (Hynes and Zhao, 2000) LRP5/6/Arrow (Heeg-Truesdell, 2006)
Secondary FlyBase IDs
	FBgn0022055 FBgn0025707 FBgn0033841 FBgn0040307
References ( 161 )
Generate a list of	All references relating to this gene ( 161 )
List References by type	Research paper  ( 63 ) Supplementary material  ( 5 ) Review  ( 40 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 23 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Conference report  ( 3 ) Stock list  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Rodal et al., 2011, J. Cell Biol. 193(1): 201--217 A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353] Konikoff et al., 2010, J. Mol. Evol. 70(4): 303--312 Distinct molecular evolutionary mechanisms underlie the functional diversification of the Wnt and TGFbeta signaling pathways. [FBrf0210842] Metcalfe et al., 2010, J. Cell Sci. 123(9): 1588--1599 Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization. [FBrf0210630] Mukai et al., 2010, EMBO J. 29(13): 2114--2125 Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. [FBrf0211204] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...