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Gene Dmel\arr

General Information
Symbol	Dmel\arr	Species	D. melanogaster
Name	arrow	Annotation symbol	CG5912
Feature type	protein_coding_gene	FlyBase ID	FBgn0000119
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	LRP, LRP5/6, CT15575
Genomic Location
Chromosome (arm)	2R	Recombination map	2-66
Cytogenetic map	50A9-50A11	Sequence location	2R:9,341,145..9,370,734 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene arrow is referred to in FlyBase by the symbol Dmel\arr (CG5912, FBgn0000119). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-activated receptor activity; Wnt-protein binding. There is experimental evidence that it is involved in the biological process: canonical Wnt receptor signaling pathway; nervous system development; regulation of compound eye pigmentation; Wnt receptor signaling pathway; protein targeting to lysosome; compound eye morphogenesis. 43 alleles are reported. The phenotypes of these alleles are annotated with: organ system; cuticle; multicellular structure; non-connected developing system; presumptive embryonic/larval nervous system; integumentary system; organ system subdivision; acellular anatomical structure; sense organ; sensillum; external compound sense organ; midgut constriction; adult segment. It has one annotated transcript and one annotated polypeptide. Protein features are: Epidermal growth factor-like domain; LDLR class B repeat; Low density lipoprotein receptor-related protein, 5/6; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Six-bladed beta-propeller, TolB-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1634211_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of arr. Gene sequence location is 2R:9341145..9370734.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	arr: arrow Embryonic lethal. Additional denticle bands anterior and posterior to normal denticle bands, especially in ventral midline. Strongest at 18.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms Wnt receptor signaling pathway involved in dorsal/ventral axis specification
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A9-50A11   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50A9-50A10     (Avery, 2000.1.11) 50A9-50A10     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-66 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)	cnn (Vaizel-Ohayon and Schejter, 1999)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\arr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) arr-RA FBtr0087702  NM_079998   6024   1678
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein arr-PA   FBpp0086821   187.5   1678   7.00     NP_524737   AAF58373
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • LDLR class B repeat (IPR000033) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Six-bladed beta-propeller, TolB-like (IPR011042) Low density lipoprotein receptor-related protein, 5/6 (IPR017049) Epidermal growth factor-like domain (IPR000742) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140895   AA391829   AE013599 AAF58373   AF223365 AAF28358   AW942154   AY005815 AAF91072   BT015250 AAT94479   BT133102   CO184554   CO187827   CO189633   CO195373   CO271371   CO275450   CO280914   CO293318   CO300657   CO300970   CO302732   CO306183   CO316290   CO321555   CO327002   CO339653   CZ488207   EC064974   EC072159   EC078214   EC195195   EC197880   EC203513   EC210756   EC210903   EC211338   EC211801   EC212558   EC220424   EC227168   EC229859   EC246092   EC257893   GH943037   GH944019   GH945075   GH947043   GH947662   GH948865   GH950939   GH954986   GH955405   GH962070   GH962654   GH962820   GH964166   GH966493   GH969165   GH975723   GH979678   GH982792   GH982894   GH983978
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z9D7 Q95V09 Q6AWJ8 Q9NHE9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with early endosome inferred from direct assay (Rives et al., 2006) colocalizes_with late endosome inferred from direct assay (Rives et al., 2006) plasma membrane inferred from direct assay (Rives et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    260.675 Larval Midgut    69.2 Larval Hindgut    125.5 Larval Malpighian Tubules    140.2 Larval Fat Body    104.5 Larval Salivary Gland    297.2 Larval Trachea    206.35 Larval Carcass    171.025 Adult Head    90.2 Adult Eye    85.825 Adult Brain    112.5 Adult Thoracic-Abdominal Ganglion    78.5 Adult Crop    121.6 Adult Midgut    79.9 Adult Hindgut    75.2 Adult Malpighian Tubules    85.1 Adult Fat Body    104.8 Adult Salivary Gland    291.6 Adult Heart    66.6 Adult VirginFemale Spermatheca    161.9 Adult InseminatedFemale Spermatheca    158.5 Adult Ovary    207.4 Adult Testis    30.7 Adult Male Accessory Gland    64.9 Adult Carcass    38.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    90.2   NA  Eye    85.825   NA  Brain    112.5   260.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    78.5   NA  Crop    121.6   69.2  Midgut    79.9   125.5  Hindgut    75.2   140.2  Malpighian Tubules    85.1   104.5  Fat Body    104.8   297.2  Salivary Gland    291.6   NA  Heart    66.6   206.35  Trachea    NA   NA  VirginFemale Spermatheca    161.9   NA  InseminatedFemale Spermatheca    158.5   NA  Ovary    207.4   NA  Testis    30.7   NA  Male Accessory Gland    64.9   171.025  Carcass    38.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (30) central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    30 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    5 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    8 head, mated 4-day male    6 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    5 fat body, larvae L3 wandering    3 fat body, white prepupae    10 fat body, pupae P8    5 carcass, larvae L3 wandering    18 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    6 ovary, mated 4-day female    6 testis, mated 4-day male    8 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (33) embryo 04-06hr  (44) embryo 06-08hr  (34) embryo 08-10hr  (32) embryo 10-12hr  (27) embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr  (35) pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (33) embryo 04-06hr  (44) embryo 06-08hr  (34) embryo 08-10hr  32 embryo 10-12hr  27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr  (35) pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    33 embryo 04-06hr    44 embryo 06-08hr    34 embryo 08-10hr    32 embryo 10-12hr    27 embryo 12-14hr    23 embryo 14-16hr    19 embryo 16-18hr    16 embryo 18-20hr    12 embryo 20-22hr    15 embryo 22-24hr    14 larva L1    8 larva L2    5 larva L3 12hr old    6 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    20 white prepupae new    23 white prepupae 12hr    22 white prepupae 24hr    35 pupae 2d postWPP    16 pupae 3d postWPP    9 pupae 4d postWPP    7 adult male 01day    10 adult male 05day    10 adult male 30day    9 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    5 embryonic 1182-4H    5 embryonic GM2    5 embryonic Kc167    6 embryonic S1    4 embryonic S3    10 leg disc CME L1    4 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    4 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    7 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    8 ovary fGS/OSS    9 ovary OSC    5 ovary OSS    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    8 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD10754 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000119 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5912-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for arr Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | partially | recessive | somatic clone arrunspecified lethal, with Scer\GAL4Act5C.PU arrGD121 arrGD2617 arrGD14404 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH arrGD121 arrGD2617 arrGD14404 lethal | embryonic stage arr1 lethal | embryonic stage | recessive arr4 arr12-1 arr16-1 arrL1 arrunspecified lethal | recessive arrk08131 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 arrGD2617 viable, with Scer\GAL4pnr-MD237 arrGD121 arrGD14404 Other Phenotypes Allele cell growth defective | somatic clone arr2 increased cell death | somatic clone arr2 planar polarity defective | cell non-autonomous | recessive | somatic clone arr2 arrG6 planar polarity defective | recessive | somatic clone arrG68 visible, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb visible | recessive | somatic clone arr2 Phenotype manifest in Allele cuticle arr12-1 arr16-1 arr4 arrL1 denticle arrunspecified denticle belt arr1 arrdsRNA.cTa embryonic/first instar larval cuticle arrdsRNA.cTa arrunspecified embryonic epidermis arrunspecified eye arr12-1 arr16-1 arr4 arrL1 eye | somatic clone arr2 arr63D eye disc | somatic clone arr63D gastric caecum arr12-1 arr16-1 arr4 arrL1 head arr12-1 arr16-1 arr4 arrL1 interommatidial bristle | somatic clone arr2 macrochaeta arrL50A midgut constriction 2 arr12-1 arr16-1 arr4 arrL1 ommatidium | ectopic | somatic clone arr2 ommatidium | somatic clone arr2 arrG6 arrG68 photoreceptor cell | somatic clone arr63D presumptive embryonic/larval central nervous system arr12-1 arr16-1 arr4 arrL1 presumptive embryonic/larval peripheral nervous system arr12-1 arr16-1 arr4 arrL1 retina | ectopic arr2 retina | somatic clone arr2 secondary pigment cell | somatic clone arr2 tertiary pigment cell | somatic clone arr2 wing, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb wing, with Scer\GAL4en-e16E arrdsRNA.Scer\UAS wing | somatic clone arr2 wing disc | somatic clone arr2 wing margin bristle | somatic clone arr2 wing sensillum | ectopic, with Scer\GAL4Bx-MS1096 arrScer\UAS.cWb
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of arr Class Mutagen Stocks Known lesion arr2 ethyl methanesulfonate 2 Yes arrEY04453 P-element activity 2 -- arrf03320 1 -- arrf05606 piggyBac transposase 1 -- arrk08131 P-element activity 1 -- arrMI03378 1 -- arrMI03803 1 -- arrMI05833 1 -- arr12-1 loss of function allele ethyl methanesulfonate 0 -- arr134 P-element activity 0 Yes arr16-1 ethyl methanesulfonate 0 Yes arr1 ethyl methanesulfonate 0 -- arr4 loss of function allele ethyl methanesulfonate 0 -- arr63D ethyl methanesulfonate 0 -- arrG68 0 -- arrG6 0 -- arrL1 ethyl methanesulfonate 0 Yes arrL50A P-element activity 0 Yes arrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of arr Class Mutagen Stocks Known lesion arrGD121 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes arrGD2617 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes arrGD14404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arrJF01260 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arrJF01261 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes arrScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 1 -- arr1185-1393 in vitro construct - RNAi 0 Yes arra.1185-1393 in vitro construct - RNAi 0 Yes arrAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes arrC.Scer\UAS.T:Myr-Src64B,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrdsRNA.cGa in vitro construct - RNAi 0 Yes arrdsRNA.cMa in vitro construct - RNAi 0 -- arrdsRNA.cTa in vitro construct - RNAi 0 Yes arrdsRNA.Scer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes arrdsRNA.Scer\UAS FLPase in vitro construct - RNAi 0 Yes arrIntra.T:Myr-Src64B,T:Zzzz\FLAG in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes arrScer\FRT.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrScer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes arrScer\UAS.cPa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrScer\UAS.cRa.T:Ivir\HA1 FLPase 0 Yes arrScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes arrScer\UAS.cWb FLPase 0 Yes arrScer\UAS.T:SS-wg,T:Avic\GFP,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes arrΔC.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)8-104 (Vaizel-Ohayon and Schejter, 1999) Df(2R)CX1 (Baker, 2005.1.6, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)vg-B (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD121} NA P{GD2617} NA P{GD14404} NA P{TRiP.JF01260} NA P{TRiP.JF01261} NA P{UAS(FRT.T:Hcri\RFP)arr.dsRNA} NA P{UAS(FRT.w+)arr.HA} NA P{UAS(-FRT)arr.HA} NA P{UAS-arr.flu} NA P{UAS-arr.FRT.Wb} NA P{UAS-arr.GFP} NA P{UAS-arr.HA} NA P{UAS-arr.Wa} NA P{UAS-arr.Wb} NA P{UAS-arr.ΔC.HA} NA characterization construct P{UAS-arr.intra.myr.FALFG} NA P{UAS-fz2:arr.intra.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}arrEY04453 NA miscellaneous insertions Mi{MIC}arrMI03378 NA Mi{MIC}arrMI03803 NA Mi{MIC}arrMI05833 NA P{?unk}arr134 NA PBac{WH}arrf03320 NA PBac{WH}arrf05606 NA insertion of enhancer trap P{lacW}arrk08131 No P{lArB}arrL50A No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
Wnt-activated receptor activity inferred from direct assay (Rives et al., 2006) Wnt-protein binding inferred from physical interaction with wg (Piddini et al., 2005)
Biological Process
CV term Evidence References
canonical Wnt receptor signaling pathway inferred from mutant phenotype (Povelones and Nusse, 2005) compound eye morphogenesis inferred from mutant phenotype (Tomlinson, 2003) nervous system development inferred from mutant phenotype (Koizumi et al., 2007) protein targeting to lysosome inferred from mutant phenotype (Piddini et al., 2005) regulation of compound eye pigmentation inferred from mutant phenotype (Lim and Tomlinson, 2006) Wnt receptor signaling pathway inferred from mutant phenotype (Wehrli et al., 2000)
Cellular Component
CV term Evidence References
colocalizes_with early endosome inferred from direct assay (Rives et al., 2006) colocalizes_with late endosome inferred from direct assay (Rives et al., 2006) plasma membrane inferred from direct assay (Rives et al., 2006)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
low-density lipoprotein receptor activity inferred from sequence or structural similarity with mouse Lrp5 AND inferred from sequence or structural similarity with mouse Lrp6 (Wehrli et al., 2000)
Biological Process
CV term Evidence References
Wnt receptor signaling pathway involved in dorsal/ventral axis specification inferred from biological aspect of ancestor with PANTHER:PTN000056248 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions arr allele Gene References arr2 arr::fz2 (Tolwinski et al., 2003) wg (Wehrli and Tomlinson, 1998) arrdsRNA.cTa Axn (Tolwinski et al., 2003) arrunspecified dsh (Wehrli et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68943 DroID - A comprehensive database of gene and protein interactions. • FBgn0000119 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44279 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A1Z9D7
Orthologs
OrthoDB Orthologs (52) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CNR9D Dipteran inclusive ortholog search EOG61VK9W Insect inclusive ortholog search EOG651CKK Arthropod inclusive ortholog search EOG6THT7X Metazoa inclusive ortholog search EOG6NPKW2
Orthologs in Drosophila Species (EOG6CNR9D)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\arr     Drosophila simulans   Dsim\GD25759     Drosophila sechellia   Dsec\GM20276 Y   Drosophila erecta   Dere\GG22489 Y   Drosophila yakuba   Dyak\GE13360 Y   Drosophila ananassae   Dana\GF11183 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19223 Y   Drosophila persimilis   Dper\GL17073 Y   Drosophila willistoni   Dwil\GK15922 Y   Drosophila virilis   Dvir\GJ19682 Y   Drosophila mojavensis   Dmoj\GI21337 Y   Drosophila grimshawi   Dgri\GH23152 Y
Orthologs in non-Drosophila Dipterans (EOG61VK9W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009806   Anopheles gambiae Malaria mosquito  Agam\AGAP011770   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000808
Orthologs in non-Dipteran Insects (EOG651CKK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51660   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009194   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19317   Atta cephalotes Leafcutter ant  Acep\ACEP15129   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20241   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23558   Linepithema humile Argentine ant  Lhum\LH17197   Linepithema humile Argentine ant  Lhum\LH18031   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22758   Solenopsis invicta Red fire ant  Sinv\SINV12711   Solenopsis invicta Red fire ant  Sinv\SINV24717   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005033   Bombyx mori Silkmoth  Bmor\BGIBMGA001048   Pediculus humanus Human body louse  Phum\PHUM086410   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08151
Orthologs in non-Insect Arthropods (EOG6THT7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_310287   Ixodes scapularis Deer tick  Isca\ISCW023971
Orthologs in non-Arthropod Metazoa (EOG6NPKW2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020325gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023044gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012372gn Y Danio rerio Zebrafish  Drer\lrp6 Y Danio rerio Zebrafish  Drer\lrp5 Y Danio rerio Zebrafish  Drer\CABZ01083440.1 Y Xenopus tropicalis Western clawed frog  Xtro\lrp6 Y Xenopus tropicalis Western clawed frog  Xtro\lrp4 Y Xenopus tropicalis Western clawed frog  Xtro\lrp5 Y Gallus gallus Domestic chicken  Ggal\LRP5 Y Gallus gallus Domestic chicken  Ggal\LRP6 Y Gallus gallus Domestic chicken  Ggal\LRP4 Y Mus musculus House mouse  Mmus\Lrp4 Y Mus musculus House mouse  Mmus\Lrp5 Y Rattus norvegicus Norway rat  Rnor\Lrp6 Y Rattus norvegicus Norway rat  Rnor\Lrp5 Y Rattus norvegicus Norway rat  Rnor\Lrp4 Y Homo sapiens Human  Hsap\LRP5 Y Homo sapiens Human  Hsap\LRP6 Y Homo sapiens Human  Hsap\LRP4 Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\LRP5     Hsap\LRP6     Hsap\LRP4
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM20276 Drosophila erecta Dere\GG22489 Drosophila yakuba Dyak\GE13360 Drosophila ananassae Dana\GF11183 Drosophila pseudoobscura pseudoobscura Dpse\GA19223 Drosophila persimilis Dper\GL17073 Drosophila willistoni Dwil\GK15922 Drosophila virilis Dvir\GJ19682 Drosophila mojavensis Dmoj\GI21337 Drosophila grimshawi Dgri\GH23152
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	31313 y1 v1; P{TRiP.JF01260}attP2 31473 y1 v1; P{TRiP.JF01261}attP2 3087 cn1 arr2 bw1 sp1/CyO 37088 y1 w*; Mi{MIC}arrMI03803/SM6a
Harvard	- PBac{WH}arrf03320 - PBac{WH}arrf05606
Kyoto	106831 cn1 arr2 bw1 sp1/CyO
VDRC	v6707 w1118; P{GD121}v6707 v6708 w1118; P{GD121}v6708 v4818 w1118; P{GD2617}v4818 v36286 w1118; P{GD14404}v36286 v4819 w1118; P{GD2617}v4819/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR36J03 BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP19005
Other clones	FI17867
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	8350 14737 42161 44443 54550 57825 61130 73346 103870 147288 165836 166903 214577.23 CK01.40B.F11 CK01.55C.F10 CK01.168B.D3 CK00539 EC28251 EC40220 EK033818 EK044755 EK103214 EK117620 EK155452 EK178924 EK179813 EK184808 EK185922 EK202554 EK250447 EK264409 EP02446 EP05433 LD10754 RP004098045 RP004105061 RP004167473 RP004193627 RP004203400 RP004205980 RP004214037 RP004216426 RP004216990 RP004233566 RP004246707 RP004247795 RP004255096 RP004336300 RP004445429 RP004478996 RP004505470 RP004521037 RP004523639 RP004528466
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000119 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44279
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: arr BEST:CK00539 (Bayraktaroglu, 2000.11.2) Source for merge of: arr LRP6 (Wehrli et al., 2000) Source for merge of: LRP6 CG5912 (Bayraktaroglu, 2000.8.7)
Additional comments	FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	dsRNA made from templates generated with primers directed against this gene. (Bartscherer et al., 2006) wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells. (Rives et al., 2006) The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment. (Piddini et al., 2005) arr gene function is essential in cells receiving wg input and it acts upstream of dsh. (Wehrli et al., 2000) Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998) Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development. (Li and Kaufman, 1996) Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects. (Li et al., 1995) Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079998 RefSeq (Proteins) • NP_524737 DDBJ / EMBL / GenBank • AA140895 AA391829 AAF28358 AAF58373 AAF91072 AAT94479 AF223365 AW942154 AY005815 BT015250 CZ488207 Entrez Gene - A searchable database of RefSeq genes. • 44279 UniProtKB/TrEMBL • A1Z9D7 Q6AWJ8 Q9NHE9 Q95V09
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • LDLR class B repeat (IPR000033) Low-density lipoprotein (LDL) receptor class A, conserved site (IPR023415) Six-bladed beta-propeller, TolB-like (IPR011042) Low density lipoprotein receptor-related protein, 5/6 (IPR017049) Epidermal growth factor-like domain (IPR000742) Low-density lipoprotein (LDL) receptor class A repeat (IPR002172) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD10754
Linkouts
	BioGRID - A database of protein and genetic interactions • 68943 DroID - A comprehensive database of gene and protein interactions. • FBgn0000119 DRSC - Results from RNAi screens. • FBgn0000119 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000119 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5912-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000119 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 351787 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44279 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/arrow1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44279 modMine - Data generated by the modENCODE project. • FBgn0000119 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • A1Z9D7
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	arr (DasGupta et al., 2005, Lim and Tomlinson, 2006, Giraldez and Cohen, 2003, Furlong, 2005, Bartscherer et al., 2006, Ma et al., 2006, Dietzl et al., 2007, Vincent et al., 2011, Koizumi et al., 2007, Chen et al., 2008, Giorgianni and Mann, 2011, Toku et al., 2011, Zecca and Struhl, 2007, Goodfellow et al., 2007, Estella et al., 2008, Baig-Lewis et al., 2007, Miech et al., 2008, Ni et al., 2008, Firth and Baker, 2009, Zirin and Mann, 2007, Blanco et al., 2009, Widmann and Dahmann, 2009, DasGupta et al., 2007, Povelones and Nusse, 2005, Silver et al., 2007, Rodal et al., 2011, Bhattacharya and Baker, 2011, Kuroda et al., 2012) Arr (Zhang et al., 2006, Seto and Bellen, 2006, Schweizer and Varmus, 2003, Mukai et al., 2010, Buechling et al., 2011) BEST:CK00539   CG5912 (Norga et al., 2003, Mirth and Akam, 2002, Wehrli, 2000.10.22, Wehrli, 2000.10.22, Ni et al., 2008) CK00539 (Kopczynski et al., 1998) CT15575 (Hynes and Zhao, 2000, Wehrli et al., 2000) Dm Arr (Konikoff et al., 2010) Irp6 (Bartscherer et al., 2006) l(2)k08131 (BDGP Project Members, 1994-1999, ) LRP (Bienz and Hamada, 2004, Furlong, 2005, Silver et al., 2007) LRP5/6 (Moon et al., 2002, Nusse, 2001) LRP6 (Avery, 2000.1.11, ) LRP/Arr (Fearon and Cadigan, 2005)
Name Synonym	Arrow (Wehrli and Baig-Lewis, 2006, Rives et al., 2006, Clevers, 2006, Tountas and Fortini, 2007, Zhang et al., 2006, Seto and Bellen, 2006, Wilson and Chuang, 2006, Marques, 2005, Baig-Lewis et al., 2007, Schweizer and Varmus, 2003, Port et al., 2008, Khaliullina et al., 2009) arrow (Schlesinger and Shilo, 2005, Stadeli, 2006, Ma et al., 2006, Hazelett et al., 2012, Vincent et al., 2011, Chen et al., 2008, Herranz et al., 2008, Goodfellow et al., 2007, Estella et al., 2008, Zirin and Mann, 2007, Chiang et al., 2009, Blanco et al., 2009, Soukup et al., 2009, Davidson et al., 2009, Widmann and Dahmann, 2009, Povelones and Nusse, 2005, Metcalfe et al., 2010, Silver et al., 2007, Rodal et al., 2011, Bhattacharya and Baker, 2011, Kuroda et al., 2012) Dm Arrow (Konikoff et al., 2010) LDL-related protein 6 (Avery, 2000.1.11) LDLR-like (Hynes and Zhao, 2000) LRP5/6/Arrow (Heeg-Truesdell, 2006)
Secondary FlyBase IDs
	FBgn0022055 FBgn0025707 FBgn0033841 FBgn0040307
References ( 175 )
Generate a list of	All references relating to this gene ( 175 )
List References by type	Research paper  ( 72 ) Supplementary material  ( 6 ) Review  ( 41 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 23 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 3 ) Stock list  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 9 )
	Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Kuroda et al., 2012, Mech. Dev. 128(11-12): 625--639 Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the Drosophila midgut. [FBrf0217619] Vied et al., 2012, Dev. Cell 23(4): 836--848 Regulation of stem cells by intersecting gradients of long-range niche signals. [FBrf0219709] Bhattacharya and Baker, 2011, Cell 147(4): 881--892 A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641] Buechling et al., 2011, EMBO Rep. 12(12): 1265--1272 p24 proteins are required for secretion of Wnt ligands. [FBrf0216831] Giorgianni and Mann, 2011, Dev. Cell 20(4): 455--468 Establishment of Medial Fates along the Proximodistal Axis of the Drosophila Leg through Direct Activation of dachshund by Distalless. [FBrf0213490] Rodal et al., 2011, J. Cell Biol. 193(1): 201--217 A presynaptic endosomal trafficking pathway controls synaptic growth signaling. [FBrf0213353] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vincent et al., 2011, Dev. Cell 21(2): 366--374 Steep differences in wingless signaling trigger myc-independent competitive cell interactions. [FBrf0214665] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...