FB2019_05, released Oct 15, 2019

Gene: Dmel\arr

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General Information
Symbol
Dmel\arr
Species
D. melanogaster
Name
arrow
Annotation Symbol
CG5912
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000119
Gene Model Status
Current
Stock Availability
25 publicly available
Gene Snapshot
arrow (arr) encodes a type I trans-membrane protein and functions as an obligate co-receptor with the product of fz for the ligand encoded by wg in the canonical Wnt signaling pathway. The product of arr is involved in developmental patterning, cell survival and growth regulation. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
LRP, LRP6, CT15575, LRP5/6, l(2)k08131
Key Links
Genomic Location
Cytogenetic map
50A9-50A11
Sequence location
2R:13,453,640..13,483,229 [-]
Recombination map
2-68
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
coreceptor activity; protein binding; Wnt-activated receptor activity; Wnt-protein binding
Predictions / Assertions
Wnt-activated receptor activity; Wnt-protein binding
Summaries
Pathway (FlyBase)
Wnt-TCF Signaling Pathway Core Components -
The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
arr: arrow
Embryonic lethal. Additional denticle bands anterior and posterior to normal denticle bands, especially in ventral midline. Strongest at 18.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\arr or the JBrowse view of Dmel\arr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
arr-RA
FBtr0087702
NM_079998
6024
1678
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
arr-PA
FBpp0086821
187.5
1678
7.00
NP_524737
AAF58373
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\arr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (16 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
coreceptor activity
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084
(Schweizer and Varmus, 2003)
protein binding
inferred from physical interaction with FLYBASE:Axn; FB:FBgn0026597
(Yang et al., 2016)
Wnt-activated receptor activity
inferred from direct assay
(Rives et al., 2006)
Wnt-protein binding
inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084
(Piddini et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Wnt-activated receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000056248
(assigned by GO_Central )
(Gaudet et al., 2011)
Wnt-protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000056248
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
canonical Wnt signaling pathway
inferred from mutant phenotype
(Povelones and Nusse, 2005, Tolwinski et al., 2003, Wehrli et al., 2000)
inferred from genetic interaction with FLYBASE:dsh; FB:FBgn0000499
(Wehrli et al., 2000)
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797, FLYBASE:wg; FB:FBgn0284084
(Schweizer and Varmus, 2003)
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Tolwinski et al., 2003)
cell elongation involved in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Widmann and Dahmann, 2009)
compound eye morphogenesis
inferred from mutant phenotype
(Tomlinson, 2003)
imaginal disc-derived wing margin morphogenesis
inferred from mutant phenotype
(Wehrli et al., 2000)
leg disc pattern formation
inferred from mutant phenotype
(Wehrli et al., 2000)
long-term memory
inferred from mutant phenotype
(Tan et al., 2013)
nervous system development
inferred from mutant phenotype
(Koizumi et al., 2007)
regulation of compound eye pigmentation
inferred from mutant phenotype
(Lim and Tomlinson, 2006)
segment polarity determination
inferred from mutant phenotype
(Tolwinski et al., 2003, Wehrli et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000056248
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
colocalizes_with early endosome
inferred from direct assay
(Rives et al., 2006)
colocalizes_with late endosome
inferred from direct assay
(Rives et al., 2006)
plasma membrane
inferred from direct assay
(Rives et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
colocalizes_with early endosome
inferred from direct assay
(Rives et al., 2006)
colocalizes_with late endosome
inferred from direct assay
(Rives et al., 2006)
plasma membrane
inferred from direct assay
(Rives et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\arr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of arr
Transgenic constructs containing regulatory region of arr
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | partially | recessive | somatic clone
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal (with Df(2R)BSC274)
lethal | recessive
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
cell growth defective | somatic clone
increased cell death | somatic clone
memory defective | RU486 conditional, with Scer\GAL4Mef2.247.Switch
planar polarity defective | cell non-autonomous | recessive | somatic clone
planar polarity defective | recessive | somatic clone
segment polarity phenotype | embryonic stage
some die during embryonic stage
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4Mef2.PR
visible | recessive | somatic clone
visible | somatic clone
Phenotype manifest in
Allele
cuticle
denticle
denticle belt
denticle belt | maternal effect
denticle field | embryonic stage
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | maternal effect
embryonic/larval cuticle | embryonic stage
embryonic epidermis
embryonic midgut constriction 2
eye
eye | somatic clone
eye disc | somatic clone
gastric caecum
head
interommatidial bristle | somatic clone
leg | somatic clone
macrochaeta
ommatidium | ectopic | somatic clone
ommatidium | somatic clone
photoreceptor cell | somatic clone
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
retina | ectopic
retina | somatic clone
secondary pigment cell | somatic clone
tertiary pigment cell | somatic clone
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4Mef2.PR
wing | somatic clone
wing disc | somatic clone
wing margin bristle | ectopic | somatic clone
wing margin bristle | somatic clone
wing sensillum | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LRP5
13 of 15
Yes
Yes
Hsap\LRP6
13 of 15
Yes
Yes
 
Hsap\LRP5L
3 of 15
No
Yes
Hsap\LRP4
2 of 15
No
No
Hsap\CD320
1 of 15
No
Yes
Hsap\EGF
1 of 15
No
No
Hsap\LDLRAD3
1 of 15
No
Yes
Hsap\LRP1B
1 of 15
No
No
Hsap\LRP1
1 of 15
No
No
Hsap\LRP2
1 of 15
No
No
Hsap\LRP11
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lrp6
13 of 15
Yes
Yes
Mmus\Lrp5
12 of 15
No
Yes
Mmus\Lrp4
2 of 15
No
No
Mmus\Dgcr2
1 of 15
No
No
Mmus\Egf
1 of 15
No
No
Mmus\Ldlrad3
1 of 15
No
Yes
Mmus\Lrp1b
1 of 15
No
No
Mmus\Lrp1
1 of 15
No
No
Mmus\Lrp2
1 of 15
No
No
Mmus\Lrp11
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
Rnor\Lrp6
9 of 13
Yes
Yes
Rnor\Lrp5
8 of 13
No
Yes
Rnor\Lrp1b
2 of 13
No
Yes
Rnor\Lrp4
2 of 13
No
No
Rnor\Cd320
1 of 13
No
Yes
Rnor\Dgcr2
1 of 13
No
Yes
Rnor\Egf
1 of 13
No
Yes
Rnor\Ldlrad3
1 of 13
No
Yes
Rnor\LOC100910275
1 of 13
No
Yes
Rnor\Lrp1
1 of 13
No
No
Rnor\Lrp11
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\lrp6
7 of 12
Yes
Yes
Xtro\lrp5
6 of 12
No
Yes
Danio rerio (Zebrafish) (10)
Drer\lrp5
13 of 15
Yes
Yes
Drer\lrp6
5 of 15
No
Yes
Drer\dgcr2
1 of 15
No
No
Drer\egf
1 of 15
No
Yes
Drer\ldlrad3
1 of 15
No
No
Drer\lrp1ab
1 of 15
No
No
Drer\lrp1ba
1 of 15
No
No
Drer\lrp1bb
1 of 15
No
No
Drer\lrp2a
1 of 15
No
No
Drer\lrp11
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\F14B4.1
1 of 15
Yes
No
Cele\lrp-1
1 of 15
Yes
No
Cele\lrp-2
1 of 15
Yes
No
Cele\rme-2
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900D7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\arr
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006576
Drosophila simulans
Dsim\GD25759
Drosophila sechellia
Dsec\GM20276
Drosophila erecta
Dere\GG22489
Drosophila yakuba
Dyak\GE13360
Drosophila ananassae
Dana\GF11183
Drosophila pseudoobscura pseudoobscura
Dpse\GA19223
Drosophila persimilis
Dper\GL17073
Drosophila willistoni
Dwil\GK15922
Drosophila virilis
Dvir\GJ19682
Drosophila mojavensis
Dmoj\GI21337
Drosophila grimshawi
Dgri\GH23152
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150097 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014029
Glossina morsitans
Tsetse fly
Gmor\GMOY009327
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10644
Mayetiola destructor
Hessian fly
Mdes\Mdes007924
Mayetiola destructor
Hessian fly
Mdes\Mdes007917
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009806
Anopheles darlingi
American malaria mosquito
Adar\ADAC000594
Anopheles gambiae
Malaria mosquito
Agam\AGAP011770
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000808
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00SP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001048
Danaus plexippus
Monarch butterfly
Dple\DPOGS200714-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010093
Apis florea
Little honeybee
Aflo\3695197284
Apis mellifera
Western honey bee
Amel\GB51660
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15295
Bombus terrestris
Buff-tailed bumblebee
Bter\15208582
Linepithema humile
Argentine ant
Lhum\LH18031
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001908
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009194
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04525
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08151
Pediculus humanus
Human body louse
Phum\PHUM086410
Cimex lectularius
Bed bug
Clec\CLEC005797
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14170
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00RF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009116
Ixodes scapularis
Black-legged tick
Isca\ISCW023971
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78305.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82476.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310287
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0178 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_020325gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lrp4
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022269
Ciona intestinalis
Vase tunicate
Cint\LOC100184434
Ciona intestinalis
Vase tunicate
Cint\lrp5/6
Gallus gallus
Domestic chicken
Ggal\LRP5
Gallus gallus
Domestic chicken
Ggal\LRP6
Gallus gallus
Domestic chicken
Ggal\LRP4
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Lrp4
3 of 10
LRP1
2 of 10
yl
2 of 10
LpR1
1 of 10
LpR2
1 of 10
mgl
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LRP5; LDL receptor related protein 5
    13 of 15
    603506
    LRP6; LDL receptor related protein 6
    13 of 15
    603507
     
    LRP5L; LDL receptor related protein 5 like
    3 of 15
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        arr - Axn
        pull down, western blot, two hybrid, anti tag coimmunoprecipitation
        (Tacchelly-Benites et al., 2018, Tolwinski et al., 2003, Yamazaki and Yanagawa, 2003)
        arr - CAP
        pull down, western blot
        (Yamazaki and Yanagawa, 2003)
        arr - dsh
        pull down, western blot
        (Yamazaki and Yanagawa, 2003)
        arr - wg
        affinity technology, fluorescence microscopy, inferred by author
        (Piddini et al., 2005)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        arr
        suppressible
        arr::fz2
        (Tolwinski et al., 2003)
        arr
        suppressible
        dsh
        (Metcalfe et al., 2010, Wehrli et al., 2000)
        arr
        suppressible
        puc
        (Giraldez and Cohen, 2003)
        arr
        enhanceable
        puc
        (Giraldez and Cohen, 2003)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        nwk
        suppressible
        arr
        (Rodal et al., 2011)
        wg
        suppressible
        arr
        (Wehrli and Tomlinson, 1998)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        Wnt-TCF Signaling Pathway Core Components -
        The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-68
        Cytogenetic map
        50A9-50A11
        Sequence location
        2R:13,453,640..13,483,229 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        50A9-50A11
        Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        50A9-50A10
        (Avery, 2000.1.11, BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location
        2-68
        (FlyBase, 2016)
        2-72.3
        (Comeron et al., 2012)
        2-66
        (Tearle and Nusslein-Volhard, 1987)
        Left of (cM)
        Right of (cM)
        (Vaizel-Ohayon and Schejter, 1999)
        Notes
        Stocks and Reagents
        Stocks (25)
        Genomic Clones (42)
        cDNA Clones (53)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: LRP6 CG5912
          (Bayraktaroglu, 2000.8.7)
          Source for merge of: arr LRP6
          (Wehrli et al., 2000)
          Source for merge of: arr BEST:CK00539
          (Bayraktaroglu, 2000.11.2)
          Additional comments
          FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970.
          (Bloomington Drosophila Stock Center, 2004.11.6)
          Other Comments
          Reducing arr expression, specifically in adult mushroom bodies, impairs long-term memory expression without altering other temporally or mechanistically distinct forms of olfactory memory.
          (Tan et al., 2013)
          dsRNA made from templates generated with primers directed against this gene.
          (Bartscherer et al., 2006)
          wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells.
          (Rives et al., 2006)
          The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment.
          (Piddini et al., 2005)
          arr gene function is essential in cells receiving wg input and it acts upstream of dsh.
          (Wehrli et al., 2000)
          Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
          (Kopczynski et al., 1998)
          Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development.
          (Li and Kaufman, 1996)
          Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects.
          (Li et al., 1995)
          Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 51 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          modMine - A data warehouse for the modENCODE project
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (19)
          Reported As
          Symbol Synonym
          Arr
          (Billmann et al., 2018, Waghmare and Page-McCaw, 2018, Wang et al., 2016, Jenny and Basler, 2014, Schilling et al., 2014, Mbodj et al., 2013, Serysheva et al., 2013, Zhang et al., 2013, Buechling et al., 2011, Mukai et al., 2010, Seto and Bellen, 2006, Zhang et al., 2006, Schweizer and Varmus, 2003)
          BEST:CK00539
          CG5912
          (Ni et al., 2010.12.1, Perkins et al., 2009, Ni et al., 2008, Norga et al., 2003, Mirth and Akam, 2002, Wehrli, 2000.10.22, Wehrli, 2000.10.22)
          CK00539
          (Kopczynski et al., 1998)
          CT15575
          (Hynes and Zhao, 2000, Wehrli et al., 2000)
          Dm Arr
          (Konikoff et al., 2010)
          Irp6
          (Bartscherer et al., 2006)
          LRP
          (Jenny and Basler, 2014, Silver et al., 2007, Furlong, 2005, Bienz and Hamada, 2004)
          LRP/Arr
          (Fearon and Cadigan, 2005)
          LRP5/6
          (Moon et al., 2002, Nusse, 2001)
          LRP6
          (Avery, 2000.1.11)
          arr
          (Xu et al., 2019, Huang et al., 2018, Newcomb et al., 2018, Saito-Diaz et al., 2018, Kaur et al., 2017, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Moulton and Letsou, 2016, Tian et al., 2016, Gene Disruption Project members, 2015-, Mannava and Tolwinski, 2015, Sugie et al., 2015, Gersten et al., 2014, Kerr et al., 2014, Howlett et al., 2013, Serysheva et al., 2013, Webber et al., 2013, Kuroda et al., 2012, Bhattacharya and Baker, 2011, Giorgianni and Mann, 2011, Rodal et al., 2011, Toku et al., 2011, Vincent et al., 2011, Metcalfe et al., 2010, Blanco et al., 2009, Firth and Baker, 2009, Widmann and Dahmann, 2009, Chen et al., 2008, Estella et al., 2008, Miech et al., 2008, Ni et al., 2008, Baig-Lewis et al., 2007, DasGupta et al., 2007, Dietzl et al., 2007, Goodfellow et al., 2007, Koizumi et al., 2007, Silver et al., 2007, Zecca and Struhl, 2007, Zirin and Mann, 2007, Bartscherer et al., 2006, Lim and Tomlinson, 2006, Ma et al., 2006, DasGupta et al., 2005, Furlong, 2005, Povelones and Nusse, 2005, Giraldez and Cohen, 2003)
          l(2)k08131
          (BDGP Project Members, 1994-1999)
          Name Synonyms
          Arrow
          (Ahmed-de-Prado and Baonza, 2018, Wang et al., 2016, Yang et al., 2016, Hall and Verheyen, 2015, Jenny and Basler, 2014, Bejsovec, 2013, Lawrence and Casal, 2013, Pepperl et al., 2013, Serysheva et al., 2013, Solis et al., 2013, Zhang et al., 2013, Koles and Budnik, 2012, Niehrs, 2012, Khaliullina et al., 2009, Port et al., 2008, Baig-Lewis et al., 2007, Tountas and Fortini, 2007, Clevers, 2006, Rives et al., 2006, Seto and Bellen, 2006, Wehrli and Baig-Lewis, 2006, Wilson and Chuang, 2006, Zhang et al., 2006, Marques, 2005, Schweizer and Varmus, 2003)
          Dm Arrow
          (Konikoff et al., 2010)
          LDL-related protein 6
          (Avery, 2000.1.11)
          LDLR-like
          (Hynes and Zhao, 2000)
          LRP5/6/Arrow
          (Heeg-Truesdell, 2006)
          arrow
          (Mottier-Pavie et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Rousselle et al., 2014, Howlett et al., 2013, Tan et al., 2013, Zhan et al., 2013, Hazelett et al., 2012, Kuroda et al., 2012, Bhattacharya and Baker, 2011, Rodal et al., 2011, Vincent et al., 2011, Metcalfe et al., 2010, Blanco et al., 2009, Chiang et al., 2009, Davidson et al., 2009, Soukup et al., 2009, Widmann and Dahmann, 2009, Chen et al., 2008, Estella et al., 2008, Herranz et al., 2008, Goodfellow et al., 2007, Silver et al., 2007, Zirin and Mann, 2007, Ma et al., 2006, Stadeli, 2006, Povelones and Nusse, 2005, Schlesinger and Shilo, 2005, Huang and Klein, 2004)
          Secondary FlyBase IDs
          • FBgn0022055
          • FBgn0025707
          • FBgn0033841
          • FBgn0040307
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (236)