LRP, CT15575, LRP6, LRP5/6, l(2)k08131
Please see the GBrowse view of Dmel\arr or the JBrowse view of Dmel\arr for information on other features
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Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\arr using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\arr in GBrowse 2
2-68
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: LRP6 CG5912
Source for merge of: arr LRP6
Source for merge of: arr BEST:CK00539
FlyBase curator comment: the insertion in the "e00083" Exelixis line (PBac{RB}CG5970e00083) was originally assigned to the arr gene in FBrf0179797, resulting in the "arre00083" (FBal0159480) allele. However, FBrf0184340 shows that the insertion is actually within CG5970.
Reducing arr expression, specifically in adult mushroom bodies, impairs long-term memory expression without altering other temporally or mechanistically distinct forms of olfactory memory.
dsRNA made from templates generated with primers directed against this gene.
Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.
Mutations in arr disrupt midgut morphogenesis and nervous system development. Failure of somatic arr- clones to grow to normal size strongly suggests that arr is essential for cell viability or proliferation or both. Germline clonal analysis reveals arr is required for germline proliferation and oocyte development.
Deficiency homozygotes for arr fail to complete embryogenesis: the second midgut constriction and the gastric caecae are missing, and axonal extension also shows defects.
Mutant alleles are embryonic lethal with extra denticle bands, especially on ventral midline.
