arrestin, Arr, ArrA, Dmarrestin, DA
Gene model reviewed during 5.50
Gene model reviewed during 5.56
1.6 (northern blot)
Phosphorylated, but does not undergo light-induced phosphorylation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arr1 using the Feature Mapper tool.
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
By PCR analysis, Rh2, Arr1, and the non-visual norpA transcripts were detected in male gonads, while ninaA, ninaE, Rh3, Rh4, Arr2, Gβ76C, and visual norpA transcripts were not detected in male gonads.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Arr1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Arr1 CG5711
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
In disrupted photoreceptor cells metarhodopsin is not stabilised until arrestin is present. In intact photoreceptor cels significant metarhodopsin stabilisation occurs even in the absence of bound arrestin.
A model for metarhodopsin inactivation has been formalised in which the stochiometric binding of arrestin determines the receptor inactivation rate. This model is supported by electrophysiological measurements of metarhodopsin inactivation in dissociated photoreceptors where cytosolic arrestin levels are genetically and physiologically manipulated.
Arr1 and Arr2 proteins have a similar function in regulating photoreceptor cell deactivation. The deactivation of the visual response in Arr2 mutants is primarily determined by Arr1 protein. Although the termination of the phototransduction cascade in wild type photoreceptors is determined by the concerted action of several feedback regulatory steps, in the absence of arrestins the termination of the phototransduction process becomes rate-limited by the slow decay of metarhodopsin.
Phosphorylated by exposure to light in the presence but not the absence (i.e., ninaE flies) of rhodopsin.
Encodes a Drosophila homologue of mammalian arrestin, a protein that interacts stoichiometrically with activated rhodopsin, inhibiting its ability to interact with the G protein, transducin, thus terminating the visual response.
Identification: Identified as a cDNA clone that is expressed exclusively or predominantly in the adult visual system.