Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
expression is first detected shortly after gastrulation commences in single cells that are in the process of segregating from the neurectoderm. ase
transcripts are expressed only in the neuroblast and not in other cells of the proneural clusters. The ase
-expressing cells give rise to the entire first wave of segregating neuroblasts and most likely all of the second and third wave neuroblasts as well. ase
transcripts are also expressed in at least some ganglion mother cells. After germ band retraction, they are found in cells in the ventral nerve cord and brain that are thought to correspond to larval neuroblasts and optic lobe anlage. In the PNS, ase
transcripts are expressed in all the sense organ precursors (SOPs) and their progeny. From stage 10 onwards, ase
transcript expression is also observed in the midgut anlage. In the wing disc, ase
transcripts are expressed in all SOPS that arise at least up until 3hrs apf. ase
is only expressed in one cell within each proneural cluster that will become the SOP. It is also expressed in SOPs in leg and antennal discs. In larval brain, ase
transcripts are detected in CNS neuroblasts and in some of their progeny and in horseshoe-shaped group of cells in the optic lobe anlage. They are also detected in the eye disc.
In third instar larvae, ase
is expressed in all imaginal discs in single cells that correspond to sensory organ mother cells (SMCs). It is also expressed in each of their two daughter cells (second order precursors) but is not detected in the final descendents of the SMC. It is also expressed in the descendents of the imaginal neuroblasts, the ganglion mother cells. Sites of ase
expression other than proneural clusters are two stripes of cells at both sides of the presumptive anterior wing margin in the wing disc, and a broad stripe of cells posterior to the morphogenetic furrow in the eye-antennal disc.
transcripts are detected in neuroblasts and their progeny. Expression peaks at stages 10-11 of embryogenesis. ase
is then detected in the CNS, the labrum, the optic lobe anlage, the procephalic neurogenic region, and the posterior midgut anlage. It is also detected in PNS precursor cells. In third instar larvae, expression is detected in imaginal discs, CNS and optic lobe.
transcripts are first detected in late stage 8 embyros and peak in stages 10 and 11. They are expressed in presumptive neural precursors once they have segregated from the ectoderm and are expressed with each wave of neuroblast segregation. Expression is also described in the primordia of the stomatogastric and optic lobes nervous systems, in the posterior midgut, in procephalic regions, and in a segmentally reiterating pattern probably in precursors to peripheral nervous system cells.