General Information
Symbol
Dmel\ase
Species
D. melanogaster
Name
asense
Annotation Symbol
CG3258
Feature Type
FlyBase ID
FBgn0000137
Gene Model Status
Stock Availability
Gene Snapshot
asense (ase) encodes a transcription factor in the achaete-scute complex. It acts together with other proneural genes in nervous system development, which involves N-mediated lateral inhibition. ase is expressed in the CNS type-I neuroblasts and the PNS sensory organ precursors (SOPs) but not in the proneural clusters that give rise to the SOP via lateral inhibition. [Date last reviewed: 2018-09-06]
Also Known As
T8, EG:165H7 .2, T1a, AS-C T8
Genomic Location
Cytogenetic map
Sequence location
X:460,747..463,176 [+]
Recombination map
1-0
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Summaries
Gene Group Membership
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
UniProt Contributed Function Data
Involved in the determination of the neuronal precursors of optic lobes in the central nervous system.
(UniProt, P09775)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
ase: asense
ase1 (formerly sc2) shown to be a molecular deletion including the ase transcription unit. ase embryos lack a subset of peripheral neurons (Dambly-Chaudiere and Ghysen, 1987, Genes Dev. 1: 297-306); third-instar larvae show disrupted optic-lobe development; in adults almost all abdominal chaetae are removed as are the extra chaetae induced by Tft. Abdomen tends to be swollen; wings poorly expanded; viability of homozygous and hemizygous females low (Garcia-Bellido, 1979, Genetics 91: 491-520). Gene expression first detectable in the neural primordium, presumably in the neuroblasts. In later embryos, RNA is detected in most cells of the CNS primordium as well as in the labrum, optic lobe rudiment, procephalic neurogenic region, and the posterior midgut rudiment. Expression lasts into germ-band retraction. Also expressed sparsely in third-instar larvae; scarce in imaginal disks except for one large cell cluster in each leg disk; strong in the CNS, especially in a cap of cells over each optic lobe, which are destined to generate ganglion mother cells of the lamina and medulla; expression also seen in inner anlagen of optic lobes, which give rise to cells of the medulla and lobula complex. Otherwise expression in brain and ventral ganglion occurs in isolated clusters of cells and single cells. Expression thought to identify actively proliferating cells (Gonzalez et al.).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\ase or the JBrowse view of Dmel\ase for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Supported by strand-specific RNA-Seq data.
Gene model reviewed during 5.51
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0070075
2430
486
Additional Transcript Data and Comments
Reported size (kB)
2.8 (northern blot)
1.6 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0070074
53.2
486
7.21
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
396 (aa); 43.5 (kD)
Comments
External Data
Subunit Structure (UniProtKB)
Efficient DNA binding requires dimerization with another bHLH protein.
(UniProt, P09775)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ase using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (21 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000358347
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000358347
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000358347
(assigned by GO_Central )
Biological Process (13 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001420656
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000358347
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000358347
(assigned by GO_Central )
Expression Data
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
ase expression is first detected shortly after gastrulation commences in single cells that are in the process of segregating from the neurectoderm. ase transcripts are expressed only in the neuroblast and not in other cells of the proneural clusters. The ase-expressing cells give rise to the entire first wave of segregating neuroblasts and most likely all of the second and third wave neuroblasts as well. ase transcripts are also expressed in at least some ganglion mother cells. After germ band retraction, they are found in cells in the ventral nerve cord and brain that are thought to correspond to larval neuroblasts and optic lobe anlage. In the PNS, ase transcripts are expressed in all the sense organ precursors (SOPs) and their progeny. From stage 10 onwards, ase transcript expression is also observed in the midgut anlage. In the wing disc, ase transcripts are expressed in all SOPS that arise at least up until 3hrs apf. ase is only expressed in one cell within each proneural cluster that will become the SOP. It is also expressed in SOPs in leg and antennal discs. In larval brain, ase transcripts are detected in CNS neuroblasts and in some of their progeny and in horseshoe-shaped group of cells in the optic lobe anlage. They are also detected in the eye disc.
In third instar larvae, ase is expressed in all imaginal discs in single cells that correspond to sensory organ mother cells (SMCs). It is also expressed in each of their two daughter cells (second order precursors) but is not detected in the final descendents of the SMC. It is also expressed in the descendents of the imaginal neuroblasts, the ganglion mother cells. Sites of ase expression other than proneural clusters are two stripes of cells at both sides of the presumptive anterior wing margin in the wing disc, and a broad stripe of cells posterior to the morphogenetic furrow in the eye-antennal disc.
ase transcripts are detected in neuroblasts and their progeny. Expression peaks at stages 10-11 of embryogenesis. ase is then detected in the CNS, the labrum, the optic lobe anlage, the procephalic neurogenic region, and the posterior midgut anlage. It is also detected in PNS precursor cells. In third instar larvae, expression is detected in imaginal discs, CNS and optic lobe.
ase transcripts are first detected in late stage 8 embyros and peak in stages 10 and 11. They are expressed in presumptive neural precursors once they have segregated from the ectoderm and are expressed with each wave of neuroblast segregation. Expression is also described in the primordia of the stomatogastric and optic lobes nervous systems, in the posterior midgut, in procephalic regions, and in a segmentally reiterating pattern probably in precursors to peripheral nervous system cells.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
ase-protein expression can be found in dpn-positive neuroblasts and ganglion mother cells in the distal part of the inner proliferation zone in the larval optic anlage.
ase expression is first detected shortly after gastrulation commences in the nuclei of single cells that are in the process of segregating from the neurectoderm. ase protein is expressed only in the neuroblast and not in other cells of the proneural clusters. The ase-expressing cells give rise to the entire first wave of segregating neuroblasts and most likely all of the second and third wave neuroblasts as well. ase protein is also expressed in at least some ganglion mother cells. After germ band retraction, it is found in cells in the ventral nerve cord and brain that are thought to correspond to larval neuroblasts and optic lobe anlage. In the PNS, ase protein is expressed in all the sense organ precursors (SOPs) and their progeny. From stage 10 onwards, ase protein expression is also observed in the midgut anlage. In the wing disc, ase protein is expressed in all SOPS that arise at least up until 3hrs apf. ase is only expressed in one cell within each proneural cluster that will become the SOP. It is also expressed in SOPs in leg and antennal discs. In larval brain, ase protein is detected in CNS neuroblasts and in some of their progeny and in horseshoe-shaped group of cells in the optic lobe anlage.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ase in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Allele of ase
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ase
Allele of ase
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of ase
characterization construct
GAL4 construct
Deletions and Duplications ( 13 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
chaeta | ectopic & mesothoracic tergum, with Scer\GAL4C-765
sensillum campaniformium | ectopic & wing, with Scer\GAL4C-765
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
No
 
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
4 of 13
Yes
No
4 of 13
Yes
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
3 of 12
Yes
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (21)
5 of 15
Yes
No
5 of 15
Yes
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
4 of 15
Yes
No
3 of 15
No
Yes
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No orthologs reported.
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909TX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CIT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0M8C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0GG3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please look at the Interaction Group reports for full details of the physical interactions
    protein-protein
    Interacting group
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Efficient DNA binding requires dimerization with another bHLH protein.
    (UniProt, P09775 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-0
    Cytogenetic map
    Sequence location
    X:460,747..463,176 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    1B3-1B3
    Limits computationally determined from genome sequence between P{EP}CG17896EP1320&P{EP}EP1398 and P{EP}svrEP356&P{EP}argEP452
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    1B3-1B3
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (7)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (5)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: ase CG3258
      Source for database merge of
      Additional comments
      Other Comments
      The Li and Graur method estimates the duplication time of two paralogous genes when the divergence time between the species is known. Using this method the duplication time between sc and Dsim\sc, and ase and Dsim\ase is estimated 50 MYA.
      ac-sc mutants are epistatic over E(spl)-C mutants.
      All proneural proteins are similarly able to promote the segregation of a neural precursor at the MP2 neuroblast position but show distinct capacities in its specification.
      Loss of function mutations in the AS-C lead to a significant reduction in sensory bristles and glial cells.
      ase may be a neural precursor gene, rather than a proneural gene. Its products are found in the neural precursor during its formation but not in the proneural cluster of cells that gave rise to the neural precursor cell. Its expression persists longer than that of other proneural genes. The expression of ase is apparently downstream of the proneural and neurogenic genes, and its ectopic expression bypasses the requirement for ac and sc in the formation of the imaginal sense organs.
      Defects due to ase mutations are enhanced by the haploid condition of other genes of the ASC, and can be corrected by an ase transgene. ase has a proneural function that participates in the singling out of the sensory mother cells that give rise to the recurved bristles of the anterior wing margin, and ectopically expressed ase generates extra sense organs.
      The neural precursor regulatory element of ase has been defined, and contains binding sites for heterodimers between the products of the da and ac and sc loci.
      The ase transcription unit shows high homology to the basic domain of the ac, sc and l(1)sc genes as revealed by cross-hybridization studies. The initiation of ase transcription is shifted temporally and spatially in relation to the other genes of the ASC, this implies that the ase promoter responds to specific positional cues for its expression.
      The achaete-scute complex defines the basic topology of the sense organ pattern, rather than the type or precise location of the elements. ase is sufficient for the development of Class C neurons: a set of segmentally repeated multi-innervated structures and several mono-innervated sense organs. The ase function can to some extent be substituted by pcl.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 34 )
      Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMine - An integrated database for Drosophila genomics
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Synonyms and Secondary IDs (18)
      Reported As
      Symbol Synonym
      ASC
      sc/T8
      Secondary FlyBase IDs
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (313)