sting, stellate-interacting gene
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
866 (aa); 99 (kD predicted)
Interacts with vas and AGO3 (PubMed:18590813, PubMed:19959991). Interacts (when methylated on arginine residues) with tud (PubMed:18590813, PubMed:19926723, PubMed:19959991, PubMed:20713507). Forms a complex with smg, twin, AGO3, nos mRNA and piRNAs that targets the nos 3'-untranslated region, in early embryos (PubMed:20953170). Interacts with nos mRNA and rump (in an RNA-dependent manner) (PubMed:20937269). Interacts with papi and vret (PubMed:21447556, PubMed:21831924). Interacts with me31B (PubMed:28945271).
Symmetrical dimethylation on Arg-11, Arg-13 and/or Arg-15, most likely by csul, is required for binding to tud, localization to the pole plasm and association with the correct piRNAs.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\aub using the Feature Mapper tool.
osk transcripts are detected at high levels in the germarium, at low levels during mid-oogenesis, and then at high levels in nurse cells and the ooctye from about stage S6 of oogenesis.
GBrowse - Visual display of RNA-Seq signalsView Dmel\aub in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
aub mutations act as genetic enhancers of Segregation Distorter. This effect is still seen when aub mutations are targeted (by homologous recombination) to the Dp(2;2)RanGAPSD chromosome, indicating that the effect of aub mutations is not specific to the target Rsp-bearing chromosome.
aub is required for maintenance of long-distance chromosomal interactions between endogenous PcG target loci.
aub is required for the accumulation of repeat-associated small interfering RNAs (rasiRNAs).
aub mutants block RNAi activation which normally occurs during egg maturation.
Mutant alleles are female sterile, laying spindle shaped eggs with defective dorsal appendages; if fertilised the embryos show a posterior group phenotype.