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Gene Dmel\aub

General Information
Symbol	Dmel\aub	Species	D. melanogaster
Name	aubergine	Annotation symbol	CG6137
Feature type	protein_coding_gene	FlyBase ID	FBgn0000146
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	sting
Genomic Location
Chromosome (arm)	2L	Recombination map	2-39
Cytogenetic map	32C1-32C1	Sequence location	2L:10,997,819..11,001,489 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene aubergine is referred to in FlyBase by the symbol Dmel\aub (CG6137, FBgn0000146). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: piRNA binding; RNA binding. There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; cellular process involved in reproduction; multicellular organismal reproductive process; anatomical structure development; regulation of metabolic process; regulation of cellular macromolecule biosynthetic process; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; cell cycle; regulation of multicellular organismal development. 28 alleles are reported. The phenotypes of these alleles are annotated with: cystoblast; spermatid; karyosome; chorion; spermatocyte; female germline stem cell; dorsal appendage. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Argonaute/Dicer protein, PAZ; Ribonuclease H-like; Stem cell self-renewal protein Piwi. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631626_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of aub. Gene sequence location is 2L:10997819..11001489.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	aub: aubergine (T. Schupbach) Female sterile; homozygous females lay eggs which are of variable shapes; in the most extreme cases, the eggs are longer than the normal, more pointed at the posterior end, and lack dorsal appendages, resembling eggs produced by the dominant female-sterile mutation Fs(2)G.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Handler et al., 2011, EMBO J. 30(19): 3977--3993 Khurana et al., 2010, PLoS Genet. 6(12): e1001246 Rouget et al., 2010, Nature 467(7319): 1128--1132 Thomsen et al., 2010, Genome Biol. 11(9): R93 Anne, 2010, PLoS ONE 5(12): e14362 Zhang et al., 2011, Mol. Cell 44(4): 572--584 Zamparini et al., 2011, Development 138(18): 4039--4050 Liu et al., 2010, Genes Dev. 24(17): 1876--1881 Controlled Vocabulary Terms positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Sequence features BKN21303 HFA03486
FB2011_10	References Kibanov et al., 2011, Mol. Biol. Cell 22(18): 3410--3419 Saito et al., 2010, Genes Dev. 24(22): 2493--2498
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32C1-32C1   Limits computationally determined from genome sequence between P{lacW}l(2)k05812k05812&P{lacW}l(2)k09104k09104 and P{EP}ppoEP2478&P{lacW}l(2)k15817k15817
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32D-32D     (Schaefer, 1995.12.20)
Experimentally Determined Recombination Data
Location	2-39
Left of (cM)
Right of (cM)	P{NM}31E (Harris and Macdonald, 2001)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\aub for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) aub-RA FBtr0080165  NM_057386   2838   866 aub-RC FBtr0112793  NM_001103674   2704   795
Additional Transcript Data & Comments
Reported size (kB)	3.0 (northern blot) (Schmidt et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein aub-PA   FBpp0079754   98.6   866   9.65     NP_476734   AAF53046 aub-PC   FBpp0111705   91.5   795   9.53     NP_001097144   ABV53667
Additional Polypeptide Data & Comments
Reported size (kDa)	866 (aa); 99 (kD predicted) (Schmidt et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease H-like (IPR012337) Argonaute/Dicer protein, PAZ (IPR003100) Stem cell self-renewal protein Piwi (IPR003165)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440254   AA696564   AA736056   AA817492   AA817640   AA940831   AA952026   AE014134 AAF53046   AE014134 ABV53667   AC005116   AC092226   AF145680 AAD38655   AF334408 AAK43547   AI455313   AI456065   AI541648   AI542906   AI544388   BF486974   BF488645   BF494972   BF494990   BF502146   BF505137   BG641173   BH809487   BI163041   BI166408   BI168219   BI169070   BI353998   BI356173   BI632822   BI639204   BI639215   BP546255   CZ466890   CZ473849   CZ473850   EV574964   EV577732   EV581028   EV582738   EV583759   EV584135   EV585486   GH754451   GH756231   GH757311   GH758143   GH771518   GH772041   GH777187   GH777917   GH778692   GH779026   GH780693   GH781233   GH782202   GH783801   GH785263   GH785779   GH790880   GH793923   GH795529   GH799202   GH800154   GH800487   GH807913   GH807966   GH809629   GH809643   GH814367   GH814753   GH815331   GH823557   GH824510   GH825461   GH828077   GH828230   GH834113   GH836680   GH836917   GH837949   GH839436   GH840523   GH840605   GH841117   GH844299   GH844737   GH846438   GH846843   GH847900   GH850492   GH853161   GH853979   GH858442   GH861128   GH862761   GH863000   GH865816   GH867295   GH869627   GH870743   GH871214   GH871358   GH872700   GH873241   GH875147   GH880312   GH880404   GH881082   GH881644   GH882845   GH882900   GH885810   GH888721   GH889645   GH890381   GH891226   GH893714   GH894018   GH895356   GH896894   GH898348   GH899191   GH900859   GH901216   GH902406   GH903632   GH906720   GH908141   GH908680   GH909840   GH911569   GH912889   GH914076   GH914812   GH914926   GH916444   GH917986   GH926839   GH928163   GH928907   GH928933   GH929220   GH929814   GH933293   GH933962   GH934523   GH938423   GH940225   X94613 CAA64320
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76922 Q95PE5 A8DYZ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References insertion site P{lacW}aub[sting-1] 2L:11,001,470..11,001,471 evidence=experimental (Schmidt et al., 1996, Schmidt et al., 1999)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (Schmidt et al., 1999) adult stage | male   testis   (Schmidt et al., 1999)
Additional Descriptive Data
	aub transcripts are detected in testis and ovary RNA on northerns and appear to accumulate exclusively in the gonads. (Schmidt et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000146    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000146 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000146 expression level Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2618) embryo 02-04hr  (2498) embryo 04-06hr  (802) embryo 06-08hr  (536) embryo 08-10hr  (563) embryo 10-12hr  (288) embryo 12-14hr  (338) embryo 14-16hr  (290) embryo 16-18hr  (232) embryo 18-20hr  (112) embryo 20-22hr  (380) embryo 22-24hr  (386) larva L1    76 larva L2    78 larva L3 12hr old  105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9  104 white prepupae new  (123) white prepupae 12hr  (156) white prepupae 24hr  (184) pupae 2d postWPP  (151) pupae 3d postWPP  (129) pupae 4d postWPP  (245) adult male 01day  (190) adult male 05day  (263) adult male 30day  (252) adult female 01day  (2216) adult female 05day  (3392) adult female 30day  (2886) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2618) embryo 02-04hr  (2498) embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day  (2216) adult female 05day  (3392) adult female 30day  (2886) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000146 expression level Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2618) embryo 02-04hr  (2498) embryo 04-06hr  (802) embryo 06-08hr  (536) embryo 08-10hr  (563) embryo 10-12hr  (288) embryo 12-14hr  (338) embryo 14-16hr  (290) embryo 16-18hr  (232) embryo 18-20hr  112 embryo 20-22hr  (380) embryo 22-24hr  (386) larva L1    76 larva L2    78 larva L3 12hr old  105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9  104 white prepupae new  123 white prepupae 12hr  (156) white prepupae 24hr  (184) pupae 2d postWPP  (151) pupae 3d postWPP  129 pupae 4d postWPP  (245) adult male 01day  (190) adult male 05day  (263) adult male 30day  (252) adult female 01day  (2216) adult female 05day  (3392) adult female 30day  (2886) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2618) embryo 02-04hr  (2498) embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day  2216 adult female 05day  (3392) adult female 30day  (2886) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2618 embryo 02-04hr    2498 embryo 04-06hr    802 embryo 06-08hr    536 embryo 08-10hr    563 embryo 10-12hr    288 embryo 12-14hr    338 embryo 14-16hr    290 embryo 16-18hr    232 embryo 18-20hr    112 embryo 20-22hr    380 embryo 22-24hr    386 larva L1    76 larva L2    78 larva L3 12hr old    105 larva L3 puffstage 1-2    73 larva L3 puffstage 3-6    84 larva L3 puffstage 7-9    104 white prepupae new    123 white prepupae 12hr    156 white prepupae 24hr    184 pupae 2d postWPP    151 pupae 3d postWPP    129 pupae 4d postWPP    245 adult male 01day    190 adult male 05day    263 adult male 30day    252 adult female 01day    2216 adult female 05day    3392 adult female 30day    2886 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000146    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000146 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000146 expression level Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000146 expression level Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut no informative data Larval Hindgut    3.6 Larval Malpighian Tubules    4.5 Larval Fat Body    26.7 Larval Salivary Gland    5.7 Larval Trachea    3.1 Larval Carcass    8.525 Adult Head    4 Adult Eye    1.375 Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    4.4 Adult Midgut no informative data Adult Hindgut    4.5 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    76.125 Adult VirginFemale Spermatheca    4.7 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    338.2 Adult Testis    93.5 Adult Male Accessory Gland    7.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4   NA  Eye    1.375   NA  Brain    no informative data   18.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    4.4   no informative data  Midgut    no informative data   3.6  Hindgut    4.5   4.5  Malpighian Tubules    no informative data   26.7  Fat Body    no informative data   5.7  Salivary Gland    no informative data   NA  Heart    76.125   3.1  Trachea    NA   NA  VirginFemale Spermatheca    4.7   NA  InseminatedFemale Spermatheca    4.2   NA  Ovary    338.2   NA  Testis    93.5   NA  Male Accessory Gland    7.5   8.525  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000146 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6137-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect (with aubHN56) aubQC42 lethal | embryonic stage | maternal effect (with aubQC42) aubHN56 lethal | embryonic stage | non-rescuable maternal effect | recessive aubsting-3a lethal | maternal effect | recessive aubAHN aubAWE13 aubHM23 aubHN2 aubK86 aubN11 aubOC aubQC42 viable, with Scer\GAL4pnr-MD237 aubGD11831 Sterility Allele female sterile aubAHN aubAWE13 aubHM23 aubHN2 aubOC aubQC42 female sterile, with Scer\GAL4nos.PG, Scer\GAL4nos.UTR.T:Hsim\VP16, Scer\GAL4otu.T:Hsim\VP16 aubdsRNA.shRNA.Scer\UAS.P\T female sterile | recessive aubsting-3a male sterile (with aubsting-1) aubsting-3a male sterile (with aubsting-3a) aubsting-1 male sterile | recessive aubsting-1 Other Phenotypes Allele mitotic cell cycle defective | female (with aubHN2) aubN11 mitotic cell cycle defective | female (with aubN11) aubHN2 suppressor of variegation aubQC42 aubΔP-3a suppressor of variegation, with P{T1(-FRT)}T190-177 aubQC42 suppressor of variegation, with P{T1}T190-177 aubQC42 wild-type aubtMR-1 aubtMR-2 aubtMR-3 Phenotype manifest in Allele chorion (with aubHN2) aubQC42 chorion (with aubQC42) aubHN2 cystoblast (with aubHN2) aubN11 cystoblast (with aubN11) aubHN2 dorsal appendage (with aubHN2) aubQC42 dorsal appendage (with aubHN56) aubQC42 dorsal appendage (with aubQC42) aubHN2 aubHN56 embryo | maternal effect | posterior aubAHN aubAWE13 aubHM23 aubHN2 aubK86 aubN11 aubQC42 embryonic/larval cuticle | embryonic stage (with aubN11) aubQC42 embryonic/larval cuticle | embryonic stage (with aubQC42) aubN11 embryonic/larval cuticle | embryonic stage | maternal effect (with aubHN2) aubN11 embryonic/larval cuticle | embryonic stage | maternal effect (with aubN11) aubHN2 female germline stem cell (with aubHN2) aubN11 female germline stem cell (with aubN11) aubHN2 karyosome aubunspecified spermatid aubsting-1 spermatid (with aubsting-1) aubsting-3a spermatid (with aubsting-3a) aubsting-1 spermatocyte aubsting-1 spermatocyte (with aubsting-1) aubsting-3a spermatocyte (with aubsting-3a) aubsting-1
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of aub Class Mutagen Stocks Known lesion aubc01100 piggyBac transposase 1 -- aubd04301 P-element activity 1 -- aubHN2 ethyl methanesulfonate 1 Yes aubKG05389 P-element activity 1 -- aubLL06590 1 -- aubQC42 ethyl methanesulfonate 1 -- aubAHN ethyl methanesulfonate 0 -- aubAWE13 ethyl methanesulfonate 0 -- aubHM23 ethyl methanesulfonate 0 -- aubHN56 0 -- aubK86 ethyl methanesulfonate 0 Yes aubN11 ethyl methanesulfonate 0 Yes aubOC ethyl methanesulfonate 0 -- aubsting-1 P-element activity 0 Yes aubsting-3a Delta2-3 0 Yes aubunspecified 0 -- aubΔP-3a 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of aub Class Mutagen Stocks Known lesion aubGD11831 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes aubGL00076 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aubHMS00611 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aubJF01390 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aubKK101252 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aubdsRNA.cDa in vitro construct - RNAi 0 Yes aubdsRNA.shRNA.Scer\UAS.P\T in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes aubScer\UAS.P\T.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aubtMR-1 in vitro construct - genomic fragment 0 Yes aubtMR-2 in vitro construct - genomic fragment 0 Yes aubtMR-3 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)aubsting-3a (Schmidt et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11831} NA P{KK101252} NA P{TRiP.GL00076} NA P{TRiP.HMS00611} NA P{TRiP.JF01390} NA P{UASp-aub.shRNA} NA P{UASp-GFP-aub.H} NA reporter construct P{aub-lacZ.1} No P{aub-lacZ.2} No characterization construct P{aubtMR-1} NA P{aubtMR-2} NA P{aubtMR-3} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}aubKG05389 NA PBac{PB}aubc01100 NA PBac{SAstopDsRed}aubLL06590 NA insertion of mobile activating element P{XP}aubd04301 NA insertion of enhancer trap P{lacW}aubsting-1 No
Gene Ontology: Function, Process & Cellular Component ( 28 unique terms )
Terms Based on Experimental Evidence ( 20 terms )
Molecular Function
CV term Evidence References
piRNA binding inferred from direct assay (Nagao et al., 2010) RNA binding inferred from direct assay (Brennecke et al., 2007)
Biological Process
CV term Evidence References
chromatin silencing inferred from mutant phenotype (Pal-Bhadra et al., 2004, Grimaud et al., 2006) dorsal appendage formation inferred from mutant phenotype (Schupbach and Wieschaus, 1991, Klattenhoff et al., 2007) mitotic chromosome condensation inferred from mutant phenotype (Pek and Kai, 2011) negative regulation of transposition inferred from mutant phenotype (Simmons et al., 2007) oocyte maturation inferred from mutant phenotype (Kennerdell et al., 2002) oogenesis inferred from mutant phenotype (Schupbach and Wieschaus, 1991) pole cell formation inferred from genetic interaction with osk (Harris and Macdonald, 2001) pole plasm protein localization inferred from mutant phenotype (Klattenhoff et al., 2007) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening inferred from mutant phenotype (Rouget et al., 2010) regulation of pole plasm oskar mRNA localization inferred from mutant phenotype (Cook et al., 2004) RNA interference inferred from mutant phenotype (Tomari et al., 2004) segmentation inferred from genetic interaction with nos (Becalska et al., 2011) targeting of mRNA for destruction involved in RNA interference inferred from mutant phenotype (Kennerdell et al., 2002)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) cytoplasm inferred from direct assay (Brennecke et al., 2007, Harris and Macdonald, 2001) microtubule associated complex inferred from direct assay (Hughes et al., 2008) P granule inferred from direct assay (Harris and Macdonald, 2001) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cystoblast division inferred from sequence or structural similarity with EMBL:AF104260 (FlyBase, 1992-) karyosome formation traceable author statement (Johnstone and Lasko, 2001) maintenance of pole plasm mRNA location traceable author statement (Johnstone and Lasko, 2001) nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) oogenesis traceable author statement (van Eeden and St. Johnston, 1999) positive regulation of oskar mRNA translation non-traceable author statement (Leatherman and Jongens, 2003) traceable author statement (Mahowald, 2001) regulation of oskar mRNA translation traceable author statement (van Eeden and St. Johnston, 1999, Johnstone and Lasko, 2001) regulation of translational initiation inferred from sequence or structural similarity with EMBL:AF005355 (Harris and Macdonald, 2001) RNA interference traceable author statement (Cerutti, 2003, Lavorgna et al., 2004) stem cell division inferred from sequence or structural similarity with EMBL:AF104260 (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions aub allele Gene References aubAHN osk (Wilson et al., 1996) aubAWE13 osk (Wilson et al., 1996, Wilson et al., 1996) aubHM23 osk (Wilson et al., 1996, Wilson et al., 1996) aubHN56 osk (Wilson et al., 1996) aubHN osk (Wilson et al., 1996, Wilson et al., 1996, Harris and Macdonald, 2001) aubN11 osk (Harris and Macdonald, 2001) aubsting-1 Ste (Schmidt et al., 1999, Tritto et al., 2003) unspecified lok (Klattenhoff et al., 2007) mei-41 (Klattenhoff et al., 2007) osk (Wilson et al., 1996, Wilson et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60589 DroID - A comprehensive database of gene and protein interactions. • FBgn0000146 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34524
Orthologs
Genome-wide drosophilid orthologs	Dere\GG10336 Dgri\GH10973 Dmoj\GI18157 Dpse\GA19382 Dsec\GM11225 Dsim\GD22205 Dvir\GJ14585 Dwil\GK15249 Dyak\GE13099
Curated drosophilid orthologs	Dpse\GA19382
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013692-PA Aedes aegypti (mosquito) AGAP009509-PA Anopheles gambiae (mosquito) XP_395884.2 Apis mellifera (honey bee) XP_001949497.1 Acyrthosiphon pisum (pea aphid) BGIBMGA010644-PA Bombyx mori (silk worm) CN21733 Caenorhabditis brenneri (small nematode) CBP09000 Caenorhabditis briggsae (nematode) CE09083 Caenorhabditis elegans (worm) JA04008 Caenorhabditis japonica (nematode) CPIJ002415 Culex pipens (mosquito) RP07768 Caenorhabditis remanei (nematode) RP40627 Caenorhabditis remanei (nematode) DDB0220438 Dictyostelium discoideum (amoeba) 308681 Daphnia pulex (daphnia) XP_656514 Entamoeba histolytica (anaerobic protozoan) GL50803_2902 Giardia lamblia (flagellated protozoan) 75625 Hypsipyla robusta (cedar shoot borer) ISCW004464-PA Ixodes scapularis (deer tick) XP_001602384.1 Nasonia vitripennis (wasp) PHUM005769-PA Pediculus humanus (human body louse) PP06661 Pristionchus pacificus (nematode) NP_999765.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001811159.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.240 Trypanosoma cruzi (parasitic trypanosome) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14168 NV16500 NV12150 NV10813 LH19600 ISCW011373 ISCW004464 FBgn0230801 FBgn0217254 FBgn0216893 FBgn0201792 FBgn0193614 FBgn0166170 JGI_V11_220987 JGI_V11_100816 JGI_V11_240344 JGI_V11_195225 JGI_V11_308681 FBgn0079379 FBgn0163362 FBgn0156737 FBgn0140896 FBgn0118454 FBgn0102645 FBgn0091073 CPIJ012516 CPIJ002459 CPIJ002458 CPIJ002415 BGIBMGA010644 ACYPI008719 ACYPI008672 ACYPI008448 ACYPI006961 ACYPI005740 ACYPI005423 ACYPI004735 ACYPI003869 GB10293 AGAP009509 PIWI7 PIWI4 PIWI3 PIWI2 AAEL008076 PB24372 PHUM563960 GLEAN_08711
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	8517 aubHN2 cn1 bw1/CyO 31606 y1 v1; P{TRiP.JF01390}attP2 14001 y1 w67c23; P{SUPor-P}aubKG05389 35201 y1 sc* v1; P{TRiP.GL00076}attP2 33728 y1 sc* v1; P{TRiP.HMS00611}attP2 4968 w1118; aubQC42 cn1 bw1/CyO, P{sevRas1.V12}FK1
Harvard	- P{XP}aubd04301 - PBac{PB}aubc01100
Kyoto	141834 y* w*; PBac{SAstopDsRed}aubLL06590 P{neoFRT}40A P{FRT(whs)}G13 cn1 bw1/CyO, S* bw1
VDRC	v106999 P{KK101252}VIE-260B v30124 w1118; P{GD11831}v30124 v30125 w1118; P{GD11831}v30125
Genomic Clones ( 2 )
	BACR03D06 BACR20O15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 141 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03764 AT03787 AT07309 AT17786 AT21591 AT24134 GM07892 GM10901 GM25891 LD14893 LD23087 LD24150 LD29041 LD35892 RE02337 RE06526 RE08810 RE10044 RE42255 SD05903 SD09421 SD10930 SD12449 SD21722 SD21739 SD26696
Other clones	Dmel_dig_006323_0680_3218 Dmel_dig_006795_0710_2939 Dmel_dig_008514_0592_3371 Dmel_dig_008907_0715_1823 Dmel_dig_011018_0665_1313 Dmel_dig_015619_0715_1490 Dmel_dig_021338_0674_0812 FGH104D12 LD23107 RP003006921 RP003020245 RP003035839 RP003037965 RP003041657 RP003042364 RP003047516 RP003052277 RP003055225 RP003055854 RP003063964 RP003073245 RP003081216 RP003081330 RP003107165 RP003117649 RP003141254 RP003144208 RP003148700 RP003152458 RP003156094 RP003159203 RP003160432 RP003162545 RP003170497 RP003185693 RP003202825 RP003206010 RP003206438 RP003208377 RP003218542 RP003225083 RP003229123 RP003230488 RP003233793 RP003240017 RP003242284 RP003248553 RP003258044 RP003259465 RP003262933 RP003265728 RP003267577 RP003270019 RP003273001 RP003273980 RP003275792 RP003284033 RP003286759 RP003289402 RP003293551 RP003293606 RP003299196 RP003299253 RP003313365 RP003322991 RP003324857 RP003335719 RP003371641 RP003395687 RP003411608 RP003412716 RP003417446 RP003422040 RP003422242 RP003423155 RP003426731 RP003435575 RP003440087 RP003442546 RP003451986 RP003457802 RP003460904 RP003462769 RP003476592 RP003485889 RP003487795 RP003496153 RP003499973 RP003506181 RP003511999 RP003520410 RP003529974 RP003534570 RP003543020 RP003545212 RP003548534 RP003554816 RP003555659 RP003567411 RP003579691 RP003586511 RP003590594 RP003610641 RP003616426 RP003618901 RP003622143 RP003625903 RP003629817 RP003637394 RP003642720 RP003647211 RP003658468 RP003660128 RP003674261 RP003677900
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000146 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34524
Antibody Information
	monoclonal (Nishida et al., 2007) polyclonal (Rehwinkel et al., 2006, Klattenhoff et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: aub CG6137 (Gong, 1999.11)
Source for database merge of	Source for merge of: aub sting (Schaefer, 1999.4.15) Source for merge of: sting ms(2)32D (Schmidt et al., 1999)
Additional comments
Other Comments
	aub protein exhibits Slicer activity in vitro. (Gunawardane et al., 2007) aub us required for cytotype regulation of the P-element family. (Simmons et al., 2007) aub is required for maintenance of long-distance chromosomal interactions between endogenous PcG target loci. (Grimaud et al., 2006) aub is required for the accumulation of repeat-associated small interfering RNAs (rasiRNAs). (Vagin et al., 2006) Mutations in piwi or aub result in partial loss of the methyl-K9 form of His3, most evident at minor sites within the euchromatic arms. (Pal-Bhadra et al., 2004) piwi, aub and spn-E are suppressors of repeat-induced silencing, as seen at heterochromatic tandem arrays of insertions of the P{lacW} transposon. (Pal-Bhadra et al., 2004) aub mutants block RNAi activation which normally occurs during egg maturation. (Kennerdell et al., 2002) aub is recruited to the posterior pole of the embryo in a vas-dependent manner and is a polar granule component. (Harris and Macdonald, 2001) aub is required for pole cell formation independently of its initial role in osk translation. (Harris and Macdonald, 2001) aub is required for dorso-ventral patterning and posterior body patterning. aub is required to enhance osk translation, acting through the osk 3'UTR and sequences upstream of the 3'UTR. (Wilson et al., 1996) Mutations at the aub locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991) Required for dorso-ventral patterning and posterior body patterning. aub is required to enhance osk translation, acting through the osk 3'UTR and sequences upstream of the 3'UTR.   Mutant alleles are female sterile, laying spindle shaped eggs with defective dorsal appendages; if fertilised the embryos show a posterior group phenotype.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057386 NM_001103674 RefSeq (Proteins) • NP_476734 NP_001097144 DDBJ / EMBL / GenBank • AA817492 AA940831 AAD38655 AAF53046 AAK43547 ABV53667 AC005116 AC092226 AF145680 AF334408 AF334409 AF334410 AF334411 AF334412 AI455313 BH809487 CAA64320 CZ466890 CZ473849 CZ473850 X94613 Entrez Gene - A searchable database of RefSeq genes. • 34524 UniProtKB/TrEMBL • A8DYZ0 O76922 Q95PE5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribonuclease H-like (IPR012337) Argonaute/Dicer protein, PAZ (IPR003100) Stem cell self-renewal protein Piwi (IPR003165)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60589 DroID - A comprehensive database of gene and protein interactions. • FBgn0000146 DRSC - Results from RNAi screens. • FBgn0000146 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000146 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6137-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000146 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34524 InParanoid A subset of ortholog calls from InParanoid. • AAEL013692-PA Aedes aegypti (mosquito) AGAP009509-PA Anopheles gambiae (mosquito) XP_395884.2 Apis mellifera (honey bee) XP_001949497.1 Acyrthosiphon pisum (pea aphid) BGIBMGA010644-PA Bombyx mori (silk worm) CN21733 Caenorhabditis brenneri (small nematode) CBP09000 Caenorhabditis briggsae (nematode) CE09083 Caenorhabditis elegans (worm) JA04008 Caenorhabditis japonica (nematode) CPIJ002415 Culex pipens (mosquito) RP07768 Caenorhabditis remanei (nematode) RP40627 Caenorhabditis remanei (nematode) DDB0220438 Dictyostelium discoideum (amoeba) 308681 Daphnia pulex (daphnia) XP_656514 Entamoeba histolytica (anaerobic protozoan) GL50803_2902 Giardia lamblia (flagellated protozoan) 75625 Hypsipyla robusta (cedar shoot borer) ISCW004464-PA Ixodes scapularis (deer tick) XP_001602384.1 Nasonia vitripennis (wasp) PHUM005769-PA Pediculus humanus (human body louse) PP06661 Pristionchus pacificus (nematode) NP_999765.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001811159.1 Tribolium castaneum (red flour beetle) Tc00.1047053511367.240 Trypanosoma cruzi (parasitic trypanosome) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/auberg1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34524 modMine - Data generated by the modENCODE project. • FBgn0000146 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14168 NV16500 NV12150 NV10813 LH19600 ISCW011373 ISCW004464 FBgn0230801 FBgn0217254 FBgn0216893 FBgn0201792 FBgn0193614 FBgn0166170 JGI_V11_220987 JGI_V11_100816 JGI_V11_240344 JGI_V11_195225 JGI_V11_308681 FBgn0079379 FBgn0163362 FBgn0156737 FBgn0140896 FBgn0118454 FBgn0102645 FBgn0091073 CPIJ012516 CPIJ002459 CPIJ002458 CPIJ002415 BGIBMGA010644 ACYPI008719 ACYPI008672 ACYPI008448 ACYPI006961 ACYPI005740 ACYPI005423 ACYPI004735 ACYPI003869 GB10293 AGAP009509 PIWI7 PIWI4 PIWI3 PIWI2 AAEL008076 PB24372 PHUM563960 GLEAN_08711
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	aub (Specchia et al., 2008, Jones and Macdonald, 2007, Anne et al., 2007, Kavi and Birchler, 2007, Ashraf et al., 2006, Grimaud et al., 2006, Vagin et al., 2006, Vagin et al., 2006, Reiss et al., 2004, Lim and Kai, 2007, Lau et al., 2009, Shpiz et al., 2007, Pek and Kai, 2011, Haynes et al., 2006, Kavi et al., 2006, Snee and Macdonald, 2004, Usakin et al., 2007, Brennecke et al., 2007, Kalmykova et al., 2008, Shpiz et al., 2008, Kavi and Birchler, 2008, Simmons et al., 2007, Aravin et al., 2004, Josse et al., 2007, Pane et al., 2007, Lim and Kai, 2007, Chen et al., 2007, Peng and Karpen, 2007, Jensen et al., 2008, Blumenstiel et al., 2008, Chen et al., 2007, Kirino et al., 2009, Malone et al., 2009, Shpiz et al., 2009, Navarro et al., 2009, Pek et al., 2009, Chambeyron et al., 2008, Lim et al., 2009, Li et al., 2009, Cronin et al., 2009, Lei and Corces, 2006, Cross and Simmons, 2008, Klattenhoff et al., 2009, Thomson et al., 2008, Robine et al., 2009, Herold et al., 2009, Saito et al., 2009, Lu and Clark, 2010, Patil and Kai, 2010, Kirino et al., 2010, Orsi et al., 2010, Simmons et al., 2010, Olivieri et al., 2010, Creed et al., 2010, Nagao et al., 2010, Becalska et al., 2011, Pek and Kai, 2011, Janic et al., 2010, Ni et al., 2011, Seong et al., 2011, Pelisson et al., 2007, Liu et al., 2010, Rouget et al., 2010, Anne, 2010, Khurana et al., 2010, Zamparini et al., 2011) AUB (Grewal and Elgin, 2007, Gunawardane et al., 2007, Klenov, 2008, Brower-Toland et al., 2007, Rehwinkel et al., 2006) Aub (Dorner et al., 2006, Klenov et al., 2007, Gunawardane et al., 2007, Lin, 2007, Saito et al., 2007, Kawamura et al., 2008, Nishida et al., 2007, Nishida et al., 2009, Obbard et al., 2009, Moshkovich and Lei, 2010, Kugler et al., 2010, Saito et al., 2010, Handler et al., 2011) CG6137 (Wirbelauer et al., 2005, Bell et al., 2007, Keleman et al., 2009.8.5, Herold et al., 2009, Hughes et al., 2008, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) ms(2)32D   sti (Schmidt et al., 1999) sting (Cerutti et al., 2000, Bosher and Labouesse, 2000, Hammond et al., 2001, Aravin et al., 2000, Rubin, 1999.4.23, )
Name Synonym	aubergine (Specchia et al., 2008, Schaefer, 1995.12.20, Klattenhoff et al., 2007, Ronsseray et al., 2007, Kruger, 2007, Klattenhoff et al., 2007, Ashraf et al., 2006, Lei and Corces, 2006, Reiss et al., 2004, Garcia et al., 2007, Kavi et al., 2006, Ronsseray et al., 2008, Simmons et al., 2007, Aravin et al., 2004, Josse et al., 2007, Tadros et al., 2007, Chen et al., 2007, Berdnik et al., 2008, Jensen et al., 2008, Blumenstiel et al., 2008, Malone et al., 2009, Shpiz et al., 2009, Pek et al., 2009, Lei and Corces, 2006, Cross and Simmons, 2008, Berdnik et al., 2008, Olivieri et al., 2010, Becalska et al., 2011, Janic et al., 2010, Thomsen et al., 2010) Aubergine (Vagin et al., 2006, Zamore, 2007, Pane et al., 2007, Zaratiegui, 2007, Carmi, 2006, Seydoux and Braun, 2006, Klenov et al., 2007, Gunawardane et al., 2007, Brennecke et al., 2007, Brower-Toland et al., 2007, Rehwinkel et al., 2006, Chicoine et al., 2007, Hughes et al., 2008, Kirino et al., 2009, Nishida et al., 2007, Saito et al., 2009, Nishida et al., 2009, Patil and Kai, 2010, Kirino et al., 2010, Gangaraju et al., 2011, Kugler et al., 2010, Handler et al., 2011, Zamparini et al., 2011) AUBERGINE (Ronsseray et al., 2007) stellate-interacting gene (Schmidt et al., 1999, )
Secondary FlyBase IDs
	FBgn0010310 FBgn0024835
References ( 200 )
Generate a list of	All references relating to this gene ( 200 )
List References by type	Research paper  ( 106 ) Supplementary material  ( 8 ) Review  ( 49 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 21 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Conference report  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 )
Recent research papers ( 27 )
	Becalska et al., 2011, Dev. Biol. 349(1): 46--52 Aubergine is a component of a nanos mRNA localization complex. [FBrf0212348] Gangaraju et al., 2011, Nat. Genet. 43(2): 153--158 Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. [FBrf0212873] Handler et al., 2011, EMBO J. 30(19): 3977--3993 A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. [FBrf0216344] Kibanov et al., 2011, Mol. Biol. Cell 22(18): 3410--3419 A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing. [FBrf0215572] Ni et al., 2011, Nat. Methods 8(5): 405--407 A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0213581] Pek and Kai, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(29): 12007--12012 DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. [FBrf0214405] Pek and Kai, 2011, Curr. Biol. 21(1): 39--44 A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718] Seong et al., 2011, Cell 145(7): 1049--1061 Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. [FBrf0214019] Zamparini et al., 2011, Development 138(18): 4039--4050 Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. [FBrf0214783] Zhang et al., 2011, Mol. Cell 44(4): 572--584 Heterotypic piRNA Ping-Pong Requires Qin, a Protein with Both E3 Ligase and Tudor Domains. [FBrf0216809] Anne, 2010, PLoS ONE 5(12): e14362 Targeting and anchoring tudor in the pole plasm of the Drosophila oocyte. [FBrf0212588] Creed et al., 2010, Biochem. Biophys. Res. Commun. 402(2): 384--389 Novel role of specific Tudor domains in Tudor-Aubergine protein complex assembly and distribution during Drosophila oogenesis. [FBrf0212296] Janic et al., 2010, Science 330(6012): 1824--1827 Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. [FBrf0212713] Khurana et al., 2010, PLoS Genet. 6(12): e1001246 Distinct Functions for the Drosophila piRNA Pathway in Genome Maintenance and Telomere Protection. [FBrf0212661] Kirino et al., 2010, RNA 16(1): 70--78 Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. [FBrf0209562] Kugler et al., 2010, PLoS ONE 5(2): e9048 Reduced cul-5 Activity Causes Aberrant Follicular Morphogenesis and Germ Cell Loss in Drosophila Oogenesis. [FBrf0209909] Liu et al., 2010, Genes Dev. 24(17): 1876--1881 Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. [FBrf0211676] Lu and Clark, 2010, Genome Res. 20(2): 212--227 Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila. [FBrf0209834] Moshkovich and Lei, 2010, PLoS Genet. 6(3): e1000880 HP1 Recruitment in the Absence of Argonaute Proteins in Drosophila. [FBrf0210291] Nagao et al., 2010, RNA 16(12): 2503--2515 Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. [FBrf0212366] Olivieri et al., 2010, EMBO J. 29(19): 3301--3317 An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. [FBrf0212004] Orsi et al., 2010, J. Cell Sci. 123(20): 3515--3524 Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation. [FBrf0212012] Patil and Kai, 2010, Curr. Biol. 20(8): 724--730 Repression of Retroelements in Drosophila Germline via piRNA Pathway by the Tudor Domain Protein Tejas. [FBrf0211166] Rouget et al., 2010, Nature 467(7319): 1128--1132 Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. [FBrf0212183] Saito et al., 2010, Genes Dev. 24(22): 2493--2498 Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila. [FBrf0212297] Simmons et al., 2010, Genet. Res. (Camb.) 92(4): 261--272 Maternal impairment of transposon regulation in Drosophila melanogaster by mutations in the genes aubergine, piwi and Suppressor of variegation 205. [FBrf0212081] Thomsen et al., 2010, Genome Biol. 11(9): R93 Genome-wide analysis of mRNA decay patterns during early Drosophila development. [FBrf0212195] Show all research papers ...
Recent reviews ( 1 )
	Arkov and Ramos, 2010, Trends Cell Biol. 20(8): 482--490 Building RNA-protein granules: insight from the germline. [FBrf0212430] Show all reviews ...