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Gene Dmel\aur

General Information
Symbol	Dmel\aur	Species	D. melanogaster
Name	aurora	Annotation symbol	CG3068
Feature type	protein_coding_gene	FlyBase ID	FBgn0000147
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	aurA, 87A7-9/2, ck10
Genomic Location
Chromosome (arm)	3R	Recombination map	3-53
Cytogenetic map	87A3-87A3	Sequence location	3R:7,788,852..7,790,550 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene aurora is referred to in FlyBase by the symbol Dmel\aur (CG3068, FBgn0000147). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; mitotic centrosome separation; pole cell formation; establishment of spindle orientation; asymmetric protein localization; centrosome cycle; asymmetric protein localization involved in cell fate determination; regulation of neurogenesis; centrosome duplication; centrosome separation. 35 alleles are reported. The phenotypes of these alleles are annotated with: centrosome; spindle; embryonic/larval brain; mitotic cell cycle; pole cell; embryonic/larval neuroblast; thecogen cell; aster; embryonic/larval central nervous system; eo neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627325_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of aur. Gene sequence location is 3R:7788852..7790550.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	aur: aurora Maternal-effect lethal. Embryos abnormal from nuclear cycle 9 onward. Multiple spindles assemble in long arrays with shared centrosomes. Polyploid nuclei develop with multiple centrosomes. Larval mitosis not investigated (Glover and Nusslein-Volhard). l(3)87Ac Hemizygotes pupate but form longer-than-normal pupae.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Müller et al., 2010, EMBO J. 29(19): 3344--3357 Sequence features BKN51123 BKN51001 BKN45209 BKN20239 HFA16905 Controlled Vocabulary Terms centrosome organization centrosome duplication
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87A3-87A3   Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-53 (Tearle and Nusslein-Volhard, 1987) 3-50.1 (Glover et al., 1995)
Left of (cM)	Sb (Glover et al., 1995)
Right of (cM)	sens (Glover et al., 1995)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\aur for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) aur-RA FBtr0082483  NM_057401   1573   411
Additional Transcript Data & Comments
Reported size (kB)	1.6 (longest cDNA) (Glover et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein aur-PA   FBpp0081957   46.2   411   10.09     NP_476749   AAF54723
Additional Polypeptide Data & Comments
Reported size (kDa)	421 (aa); 47 (kD predicted) (Glover et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264292   AA536367   AA539187   AA540327   AA540328   AA816407   AE014297 AAF54723   AC007889   AW942434   AX934317 CAF04019   AY061229 AAL28777   BE977400   BI161588   BI578422   BT011058   BT031349   BT099626   BT126332   CO280256   CO311060   CO323022   CO342854   DN154467   EC055449   EC059995   EC074624   EC080087   EC085336   EC235954   EC236685   EC245214   EC258411   EV584198   X83465 CAA58468   X83466 CAA58469
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q27393 Q9VGF9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160710 3R:7,788,860..7,788,877 bound_moiety=BEAF-32A-XP evidence=experimental (Hart et al., 1997, Bergman et al., 2004) protein binding site FBsf0000160711 3R:7,788,808..7,788,821 bound_moiety=BEAF-32B-XP evidence=experimental (Hart et al., 1997, Bergman et al., 2004) protein binding site FBsf0000160712 3R:7,788,830..7,788,848 bound_moiety=BEAF-32B-XP evidence=experimental (Hart et al., 1997, Bergman et al., 2004)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism   • yolk plasma | posterior (Lecuyer et al., 2007) embryonic stage 5   pole cell   (Lecuyer et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference     • centrosome (Giet et al., 2002) Comment:expression assayed in cultured cells
Additional Descriptive Data
	aur protein localizes to the centrosomes of S2 cells. (Giet et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000147    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000147 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000147 expression level Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6307) embryo 02-04hr  (3318) embryo 04-06hr  (3775) embryo 06-08hr  (4011) embryo 08-10hr  (3159) embryo 10-12hr  (1144) embryo 12-14hr  (567) embryo 14-16hr  (457) embryo 16-18hr  (290) embryo 18-20hr  (171) embryo 20-22hr  (278) embryo 22-24hr  (421) larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2  (450) larva L3 puffstage 3-6  (692) larva L3 puffstage 7-9  (862) white prepupae new  (784) white prepupae 12hr  (1762) white prepupae 24hr  (1792) pupae 2d postWPP  (1125) pupae 3d postWPP  (683) pupae 4d postWPP  (653) adult male 01day  (929) adult male 05day  (1667) adult male 30day  (1353) adult female 01day  (1179) adult female 05day  (2880) adult female 30day  (3095) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6307) embryo 02-04hr  (3318) embryo 04-06hr  (3775) embryo 06-08hr  (4011) embryo 08-10hr  (3159) embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr  (1762) white prepupae 24hr  (1792) pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day  (1667) adult male 30day    1353 adult female 01day    1179 adult female 05day  (2880) adult female 30day  (3095) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000147 expression level Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6307) embryo 02-04hr  (3318) embryo 04-06hr  (3775) embryo 06-08hr  (4011) embryo 08-10hr  (3159) embryo 10-12hr  (1144) embryo 12-14hr  (567) embryo 14-16hr  (457) embryo 16-18hr  (290) embryo 18-20hr  (171) embryo 20-22hr  (278) embryo 22-24hr  (421) larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2  (450) larva L3 puffstage 3-6  (692) larva L3 puffstage 7-9  (862) white prepupae new  (784) white prepupae 12hr  (1762) white prepupae 24hr  (1792) pupae 2d postWPP  (1125) pupae 3d postWPP  (683) pupae 4d postWPP  (653) adult male 01day  (929) adult male 05day  (1667) adult male 30day  (1353) adult female 01day  (1179) adult female 05day  (2880) adult female 30day  (3095) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6307) embryo 02-04hr  (3318) embryo 04-06hr  (3775) embryo 06-08hr  (4011) embryo 08-10hr  (3159) embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr  1762 white prepupae 24hr  1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day  1667 adult male 30day    1353 adult female 01day    1179 adult female 05day  (2880) adult female 30day  (3095) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6307 embryo 02-04hr    3318 embryo 04-06hr    3775 embryo 06-08hr    4011 embryo 08-10hr    3159 embryo 10-12hr    1144 embryo 12-14hr    567 embryo 14-16hr    457 embryo 16-18hr    290 embryo 18-20hr    171 embryo 20-22hr    278 embryo 22-24hr    421 larva L1    56 larva L2    87 larva L3 12hr old    100 larva L3 puffstage 1-2    450 larva L3 puffstage 3-6    692 larva L3 puffstage 7-9    862 white prepupae new    784 white prepupae 12hr    1762 white prepupae 24hr    1792 pupae 2d postWPP    1125 pupae 3d postWPP    683 pupae 4d postWPP    653 adult male 01day    929 adult male 05day    1667 adult male 30day    1353 adult female 01day    1179 adult female 05day    2880 adult female 30day    3095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000147    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000147 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000147 expression level Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000147 expression level Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.375 Larval Midgut    3.5 Larval Hindgut    8.7 Larval Malpighian Tubules    3.4 Larval Fat Body no informative data Larval Salivary Gland    7.4 Larval Trachea    28.725 Larval Carcass no informative data Adult Head no informative data Adult Eye    20.575 Adult Brain    13.8 Adult Thoracic-Abdominal Ganglion    17.9 Adult Crop    9.9 Adult Midgut    5.7 Adult Hindgut    5.8 Adult Malpighian Tubules    4.8 Adult Fat Body    5.3 Adult Salivary Gland    4 Adult Heart    2.225 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    3.6 Adult Ovary    316.5 Adult Testis    231.6 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    20.575   NA  Brain    13.8   92.375  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    17.9   NA  Crop    9.9   3.5  Midgut    5.7   8.7  Hindgut    5.8   3.4  Malpighian Tubules    4.8   no informative data  Fat Body    5.3   7.4  Salivary Gland    4   NA  Heart    2.225   28.725  Trachea    NA   NA  VirginFemale Spermatheca    5.3   NA  InseminatedFemale Spermatheca    3.6   NA  Ovary    316.5   NA  Testis    231.6   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000147 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3068-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | maternal effect | recessive aur1 lethal | pupal stage aur8839 aur14641 aur17961 lethal | pupal stage (with aur37) aur87Ac-3 lethal | pupal stage (with aur87Ac-3) aur37 lethal | pupal stage (with Df(3R)M-Kx1) aur37 lethal | pupal stage (with Df(3R)P-58) aur37 lethal | pupal stage | recessive aur87Ac-1 aur87Ac-3 aur87Ac-4 aur87Ac-5 aur87Ac-6 aur8839 aur14641 aur17961 semi-lethal | recessive aur87Ac-1 Sterility Allele female sterile aur87Ac-6 female sterile (with aur3) aur87Ac-3 aur87Ac-4 aur87Ac-5 female sterile (with aur87Ac-3) aur3 female sterile (with aur87Ac-4) aur3 female sterile (with aur87Ac-5) aur3 female sterile | recessive aur3 aur87Ac-1 aur87Ac-2 sterile aur1 aur3 Other Phenotypes Allele mitotic cell cycle defective aur1 aur87Ac-5 mitotic cell cycle defective (with aur87Ac-3) aur87Ac-5 mitotic cell cycle defective (with aur87Ac-4) aur87Ac-5 mitotic cell cycle defective (with aur87Ac-5) aur87Ac-3 aur87Ac-4 mitotic cell cycle defective (with Df(3R)P-79) aur87Ac-5 mitotic cell cycle defective (with Df(3R)T-47) aur87Ac-5 mitotic cell cycle defective (with Df(3R)T-61) aur3 aur87Ac-5 mitotic cell cycle defective | maternal effect aur3 mitotic cell cycle defective | recessive aur1 neuroanatomy defective aur87Ac-3 aur87Ac-5 aur8839 aur14641 aur17961 neuroanatomy defective (with aur37) aur87Ac-3 neuroanatomy defective (with aur87Ac-3) aur37 neuroanatomy defective | somatic clone aur14641 visible aur37 wild-type aur+t3.7 aur+t9 aur+t16.2 Phenotype manifest in Allele aster aurdsRNA.cGa aster & neuroblast & larva (with Df(3R)T-61) aur87Ac-5 centriole & neuroblast & larva | ectopic (with Df(3R)T-61) aur87Ac-5 centrosome aur37 centrosome & neuroblast & larva aur87Ac-5 centrosome & neuroblast & larva (with Df(3R)T-61) aur87Ac-5 centrosome | embryonic stage aurunspecified embryonic/larval brain aur87Ac-5 aurunspecified aur8839 embryonic/larval brain | larval stage (with aur37) aur87Ac-3 embryonic/larval brain | larval stage (with aur87Ac-3) aur37 embryonic/larval central nervous system aur8839 embryonic/larval neuroblast (with aur37) aur87Ac-3 embryonic/larval neuroblast (with aur87Ac-3) aur37 eo neuron (with aur37) aur87Ac-3 eo neuron (with aur87Ac-3) aur37 eo neuron (with Df(3R)M-Kx1) aur37 eo neuron (with Df(3R)P-58) aur37 eo neuron | somatic clone aur37 metaphase & condensed nuclear chromosome aurdsRNA.cGa microtubule & neuroblast & larva (with Df(3R)T-61) aur87Ac-5 microtubule | maternal effect aur3 mitotic cell cycle aurunspecified mitotic metaphase & larval brain aur87Ac-5 mitotic metaphase & larval brain (with Df(3R)P-79) aur87Ac-5 mitotic metaphase & larval brain (with Df(3R)T-47) aur87Ac-5 mitotic metaphase & larval brain (with Df(3R)T-61) aur87Ac-5 neuroblast | somatic clone | supernumerary aur14641 neuroblast | supernumerary & brain aur87Ac-3 neuroblast | supernumerary & larva aur14641 aur17961 neuroblast | supernumerary & larval brain aur8839 aur14641 aur17961 nucleus | embryonic stage aurunspecified pole cell (with aur3) aur87Ac-3 pole cell (with aur87Ac-3) aur3 sensory mother cell | somatic clone aur37 socket | ectopic | somatic clone aur37 spindle aur37 spindle & neuroblast & larva aur8839 aur14641 aur17961 spindle & sensory mother cell & pupa aur14641 thecogen cell aur37 thecogen cell (with aur37) aur87Ac-3 thecogen cell (with aur87Ac-3) aur37 thecogen cell (with Df(3R)M-Kx1) aur37 thecogen cell (with Df(3R)P-58) aur37 tormogen cell | ectopic (with aur37) aur87Ac-3 tormogen cell | ectopic (with aur87Ac-3) aur37 tormogen cell | ectopic (with Df(3R)M-Kx1) aur37 tormogen cell | ectopic (with Df(3R)P-58) aur37 tormogen cell | ectopic | somatic clone aur37 trichogen cell | ectopic (with aur37) aur87Ac-3 trichogen cell | ectopic (with aur87Ac-3) aur37 trichogen cell | ectopic (with Df(3R)M-Kx1) aur37 trichogen cell | ectopic (with Df(3R)P-58) aur37 trichogen cell | ectopic | somatic clone aur37
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of aur Class Mutagen Stocks Known lesion aur87Ac-3 amorphic allele - genetic evidence ethyl methanesulfonate 2 -- aur1 ethyl methanesulfonate 2 -- aurEY03490 P-element activity 1 Yes aurGS7173 1 Yes aur87Ac-5 neomorphic allele - genetic evidence, amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes aur14641 ethyl methanesulfonate 0 Yes aur17961 ethyl methanesulfonate 0 Yes aur2 ethyl methanesulfonate 0 -- aur37 ethyl methanesulfonate 0 Yes aur3 ethyl methanesulfonate 0 Yes aur87Ac-1 ethyl methanesulfonate 0 -- aur87Ac-2 ethyl methanesulfonate 0 -- aur87Ac-4 ethyl methanesulfonate 0 -- aur87Ac-6 ethyl methanesulfonate 0 -- aur8839 ethyl methanesulfonate 0 Yes aurST70 P-element activity 0 Yes aurunspecified 0 -- aurZIII-2400 0 -- aurZIII-2973 0 -- aurZIII-5137 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of aur Class Mutagen Stocks Known lesion aurScer\UAS.Exel in vitro construct - regulatory fusion 2 Yes aurGMR.Exel in vitro construct - regulatory fusion 1 Yes aurHM04011 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aurHMS01511 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aurKK100143 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes aur+t16.2 in vitro construct - genomic fragment 0 Yes aur+t3.7 in vitro construct - genomic fragment 0 Yes aur+t9 in vitro construct - genomic fragment 0 Yes aurdsRNA.cGa in vitro construct - RNAi 0 Yes aurdsRNA.cTa in vitro construct - RNAi 0 Yes aurGD10117 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes aurScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes aurScer\UAS.L.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aurScer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes aurVI in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC514 (Christensen et al., 2008.4.15) Df(3R)E79 (Gausz et al., 1981) Df(3R)E229 (Gausz et al., 1981, Tearle and Nusslein-Volhard, 1987, Glover et al., 1995) Df(3R)ED5558 (Ryder and Roote, 2004.11.10) Df(3R)ED5559 (Ryder and Roote, 2004.11.10) Df(3R)Exel6162 (Ryder, 2004.4.26) Df(3R)Exel6163 (Ryder, 2004.4.26) Df(3R)kar1W (Gausz et al., 1981) Df(3R)kar-D1 (Gausz et al., 1981, Tearle and Nusslein-Volhard, 1987, Yang and Ballinger, 1994, Glover et al., 1995) Df(3R)kar-H5 (Gausz et al., 1981) Df(3R)T-45 (Gausz et al., 1981) Df(3R)T-47 (Gausz et al., 1981, Yang and Ballinger, 1994, Glover et al., 1995) Df(3R)T-61 (Glover et al., 1995)
Not disrupted in	Df(3R)kar3J (Gausz et al., 1981) Df(3R)kar3Q (Gausz et al., 1981) Df(3R)kar-H10 (Gausz et al., 1981) Df(3R)kar-Sz12 (Gausz et al., 1981) Df(3R)ry615 (Gausz et al., 1981) Df(3R)T-55 (Gausz et al., 1981, Glover et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10117} NA P{KK100143} NA P{TRiP.HM04011} NA P{TRiP.HMS01511} NA P{UAS-aur.Exel} NA P{UAS-aur.GFP.L} NA P{UAS-aur.GFP} NA characterization construct P{87A.II} NA P{87A.V} NA P{87A.VIII} NA P{87Ae.VI} NA P{GMR-aur.Exel} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}aurEY03490 NA P{GSV2}aurGS7173 NA P{Mae-UAS.6.11}B0499B0499 NA insertion of enhancer trap P{PyR}35 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein serine/threonine kinase activity inferred from direct assay (Wirtz-Peitz et al., 2008)
Biological Process
CV term Evidence References
asymmetric protein localization inferred from mutant phenotype (Wang et al., 2006, Lee et al., 2006) asymmetric protein localization involved in cell fate determination inferred from mutant phenotype (Berdnik and Knoblich, 2002) centrosome cycle inferred from mutant phenotype (Berdnik and Knoblich, 2002) centrosome duplication inferred from mutant phenotype (Müller et al., 2010) centrosome organization inferred from mutant phenotype (Müller et al., 2010) centrosome separation inferred from mutant phenotype (Dobbelaere et al., 2008) establishment of spindle orientation inferred from mutant phenotype (Wang et al., 2006, Lee et al., 2006) mitotic centrosome separation inferred from mutant phenotype (Glover et al., 1995) pole cell formation inferred from mutant phenotype (Lerit and Gavis, 2011) regulation of neurogenesis inferred from mutant phenotype (Wang et al., 2006, Lee et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity (Glover et al., 1995)
Biological Process
CV term Evidence References
microtubule-based process traceable author statement (Towers and Sattelle, 2002) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
centrosome non-traceable author statement (Gergely, 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions aur allele Gene References aur87Ac-3 E(z) (Bajusz et al., 2001) aur87Ac-4 E(z) (Bajusz et al., 2001) unspecified aPKC (Wang et al., 2006) bora (Hutterer et al., 2006, Hutterer et al., 2003) dap (Wang et al., 2006) N (Wang et al., 2006) numb (Wang et al., 2006, Lee et al., 2006) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66563 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000147 DroID - A comprehensive database of gene and protein interactions. • FBgn0000147 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41446
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17839 Dere\GG18531 Dgri\GH23526 Dmoj\GI23550 Dper\GL22255 Dpse\GA15904 Dsec\GM23989 Dsim\GD18792 Dvir\GJ23510 Dwil\GK13515 Dyak\GE26150
Curated drosophilid orthologs	Dpse\GA15904   Dsim\aur (Ferree and Sullivan, 2006)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009880-PA Aedes aegypti (mosquito) XP_395732.2 Apis mellifera (honey bee) XP_001942942.1 Acyrthosiphon pisum (pea aphid) At4g32830.1 Arabidopsis thaliana (wall cress) 92000 Batrachochytrium dendrobatidis (chytrid fungus) 61299 Branchiostoma floridae (lancelet) XP_001892118.1 Brugia malayi (roundworm nematode) BGIBMGA006681-PA Bombyx mori (silk worm) ENSBTAP00000017297 Bos taurus (bovine) CAL0005060 Candida albicans (a form of yeast) CBP02759 Caenorhabditis briggsae (nematode) CE21025 Caenorhabditis elegans (worm) ENSCAFP00000025043 Canis familiaris (dog) CAGL0E05720g Candida glabrata (haploid yeast) Chro.20335 Cryptosporidium hominis (obligate parasite) JA00866 Caenorhabditis japonica (nematode) CMQ044C Cyanidioschyzon merolae (red alga) cn04229 Cryptococcus neoformans (yeast-like fungus) cgd2_3190 Cryptosporidium parvum (protozoan parasite) CPIJ007519 Culex pipens (mosquito) ENSCPOP00000005974 Cavia porcellus (guinea pig) 145741 Chlamidomonas reinhardtii (green alga) RP25169 Caenorhabditis remanei (nematode) ENSCSAVP00000013716 Ciona savignyi (sedentary tunicate) 177486 Capitella spl (polychaete worm) DDB0216254 Dictyostelium discoideum (amoeba) DEHA2C04246g Debaryomyces Hansenii (yeast) 111210 Daphnia pulex (daphnia) ENSDARP00000021253 Danio rerio (zebra fish) ENSECAP00000021467 Equus caballus (horse) XP_001914305 Entamoeba histolytica (anaerobic protozoan) XP_648271 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008424 Gymnopilus aculeatus (mushroom) ENSGALP00000032883 Gallus gallus (chicken) GL50803_5358 Giardia lamblia (flagellated protozoan) 191942 Hypsipyla robusta (cedar shoot borer) ENSP00000216911 Homo sapiens (human) ISCW002690-PA Ixodes scapularis (deer tick) 124656 Lottia gigantea (owl limpet) LmjF28.0520 Leishmania major (virus) 30263 Monocosta brevicollis (choanoflagellate) ENSMODP00000020529 Monodelphis domestica (gray opossum) ENSMMUP00000000091 Macaca mulatta (rhesus monkey) ENSMUSP00000028997 Mus musculus (house mouse) 230469 Nematostella vectensis (starlet anemone) XP_001603506.1 Nasonia vitripennis (wasp) ENSOANP00000018879 Ornithorynchus anatinus (platypus) ENSORLP00000000711 Oryzias latipes (japanese killifish) LOC_Os01g09580.1 Oryza sativa (asian rice) 12571 Ostreococcus tauri (green alga) PHUM000816-PA Pediculus humanus (human body louse) PP03281 Pristionchus pacificus (nematode) 191512 Physcomitrella patens (moss) ENSPPYP00000012456 Pongo pygmaeus (orangutan) 72082 Phytophthora ramorum (sudden oak death pathogen) 108416 Phytophthora sojae (root rot pathogen) 819526 Populus trichocarpa (black cottonwood) ENSPTRP00000023475 Pan troglodytes (chimpanzee) ENSRNOP00000051977 Rattus norvegicus (norway rat) 4877462 Sorghum bicolor (sorghum) YPL209C Saccharomyces cerevisiae (budding yeast) Smp_135360 Schistosoma mansoni (trematode parasite) SPCC320.13c Schizosaccharomyces pombe (fission yeast) XP_001181990.1 Strongylocentrotus purpuratus (purple sea urchin) 30577 Trichoplax adhaerens (metazoa) XP_968329.1 Tribolium castaneum (red flour beetle) Tc00.1047053508817.80 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009848 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033875 Takifugu rubripes (pufferfish Takifugu) 3695.m00017 Tetrahymena thermophila (ciliate protozoa) 81997.m00106 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026285 Xenopus tropicalis (frog) YALI0E34375g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18556 NV16499 NV10752 LH11649 ISCW012666 ISCW002690 FBgn0243187 FBgn0230913 FBgn0220369 FBgn0215523 FBgn0210608 FBgn0207893 FBgn0193625 FBgn0190309 FBgn0178854 FBgn0166280 JGI_V11_308251 JGI_V11_111210 FBgn0079726 FBgn0075920 FBgn0159847 FBgn0156629 FBgn0146286 FBgn0146276 FBgn0146275 FBgn0024227 FBgn0130983 FBgn0121064 FBgn0110744 FBgn0102656 FBgn0094857 FBgn0091084 CPIJ020233 CPIJ007519 BGIBMGA006681 BGIBMGA002350 ACYPI008024 ACYPI004869 ACYPI003189 GB14418 GB11910 AGAP007855 AGAP001793 AAEL015523 AAEL015375 AAEL009880 AAEL006712 PB19770 PHUM019510 PHUM331400 GLEAN_01943 GLEAN_01817
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	6188 aur87Ac-3/MKRS 8377 y1 w1118; P{UAS-aur.Exel}2 8378 y1 w1118; P{GMR-aur.Exel}2 31704 y1 v1; P{TRiP.HM04011}attP2 15904 y1 w67c23; P{EPgy2}aurEY03490 35763 y1 sc* v1; P{TRiP.HMS01511}attP40 8376 y1 w1118; P{UAS-aur.Exel}3/TM3, Sb1 Ser1 3319 Dp(1;Y)BS; ru1 st1 aur1 e1 ca1/TM3, Sb1
Kyoto	108673 aur87Ac-3/MKRS 201064 y1 w67c23; P{GSV2}aurGS7173/TM3, Sb1 Ser1 106975 Dp(1;Y)BS; ru1 st1 aur1 e1 ca1/TM3, Sb1
VDRC	v108446 P{KK100143}VIE-260B
Genomic Clones ( 2 )
	BACR03N24 BACR48E12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 30 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD16949 LP05203 LP11008 LP11561 LP13742
Other clones	DPiM_LD16949 DPiM_LP05203
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01428 LD07946 LD18843 LD19783 LD19784 RE72290
Other clones	40270 53249 63867 77105 100618 214377.49 bs63e06 CK01.12B.G5 CK01.145A.F8 Dmel_dig_006062_0696_2775 EC055449 EK153513 EK189518 EK223242 EK286506 EP15626 RE01062
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000147 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41446
Antibody Information
	polyclonal (Giet et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: aur CG3068 (Nelson, 1999.11)
Source for database merge of
Additional comments
Other Comments
	aur is involved in centrosome separation. (Dobbelaere et al., 2008) aur inhibits neuroblast self-renewal by regulating aPKC/numb protein cortical polarity and spindle orientation. (Lee et al., 2006) aur acts as a tumour suppressor by suppressing neuroblast self-renewal and promoting neural differentiation. (Wang et al., 2006) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) aur is required for centrosome maturation and actin dependant asymmetric localisation of numb during mitosis. (Berdnik and Knoblich, 2002) The mutant phenotype of aur suggests that loss of function of the serine/threonine protein kinase encoded by aur leads to a failure of the centrosomes to separate and form a bipolar spindle. (Glover et al., 1995) A 250bp region upstream of both aur and the divergently transcribed anon-87Aa corresponds to the site of a specific chromatin structure (scs') previously proposed to be a barrier to insulate enhancers of Hsp70Ab. (Glover et al., 1995) Embryos from aur mothers display closely paired centrosomes at inappropriate mitotic stages and develop interconnected spindles in which the poles are shared. Amorphic alleles of aur result in pupal lethality and mitotic arrest in which condensed chromosomes are arranged on circular monopolar spindles. The size of the single centrosomal body suggests the failure of the centrosomes to separate and form a bipolar spindle. The neuroblast phenotype of aur mutants is similar to that of mgr mutants. (Glover, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057401 RefSeq (Proteins) • NP_476749 DDBJ / EMBL / GenBank • AA536367 AAF54723 AAL28777 AC007889 AW942434 AX934317 AY061229 CAA58468 CAA58469 CAF04019 X83465 X83466 Entrez Gene - A searchable database of RefSeq genes. • 41446 UniProtKB/TrEMBL • Q9VGF9 Q27393
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66563 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000147 DroID - A comprehensive database of gene and protein interactions. • FBgn0000147 DRSC - Results from RNAi screens. • FBgn0000147 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000147 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3068-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000147 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41446 InParanoid A subset of ortholog calls from InParanoid. • AAEL009880-PA Aedes aegypti (mosquito) XP_395732.2 Apis mellifera (honey bee) XP_001942942.1 Acyrthosiphon pisum (pea aphid) At4g32830.1 Arabidopsis thaliana (wall cress) 92000 Batrachochytrium dendrobatidis (chytrid fungus) 61299 Branchiostoma floridae (lancelet) XP_001892118.1 Brugia malayi (roundworm nematode) BGIBMGA006681-PA Bombyx mori (silk worm) ENSBTAP00000017297 Bos taurus (bovine) CAL0005060 Candida albicans (a form of yeast) CBP02759 Caenorhabditis briggsae (nematode) CE21025 Caenorhabditis elegans (worm) ENSCAFP00000025043 Canis familiaris (dog) CAGL0E05720g Candida glabrata (haploid yeast) Chro.20335 Cryptosporidium hominis (obligate parasite) JA00866 Caenorhabditis japonica (nematode) CMQ044C Cyanidioschyzon merolae (red alga) cn04229 Cryptococcus neoformans (yeast-like fungus) cgd2_3190 Cryptosporidium parvum (protozoan parasite) CPIJ007519 Culex pipens (mosquito) ENSCPOP00000005974 Cavia porcellus (guinea pig) 145741 Chlamidomonas reinhardtii (green alga) RP25169 Caenorhabditis remanei (nematode) ENSCSAVP00000013716 Ciona savignyi (sedentary tunicate) 177486 Capitella spl (polychaete worm) DDB0216254 Dictyostelium discoideum (amoeba) DEHA2C04246g Debaryomyces Hansenii (yeast) 111210 Daphnia pulex (daphnia) ENSDARP00000021253 Danio rerio (zebra fish) ENSECAP00000021467 Equus caballus (horse) XP_001914305 Entamoeba histolytica (anaerobic protozoan) XP_648271 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008424 Gymnopilus aculeatus (mushroom) ENSGALP00000032883 Gallus gallus (chicken) GL50803_5358 Giardia lamblia (flagellated protozoan) 191942 Hypsipyla robusta (cedar shoot borer) ENSP00000216911 Homo sapiens (human) ISCW002690-PA Ixodes scapularis (deer tick) 124656 Lottia gigantea (owl limpet) LmjF28.0520 Leishmania major (virus) 30263 Monocosta brevicollis (choanoflagellate) ENSMODP00000020529 Monodelphis domestica (gray opossum) ENSMMUP00000000091 Macaca mulatta (rhesus monkey) ENSMUSP00000028997 Mus musculus (house mouse) 230469 Nematostella vectensis (starlet anemone) XP_001603506.1 Nasonia vitripennis (wasp) ENSOANP00000018879 Ornithorynchus anatinus (platypus) ENSORLP00000000711 Oryzias latipes (japanese killifish) LOC_Os01g09580.1 Oryza sativa (asian rice) 12571 Ostreococcus tauri (green alga) PHUM000816-PA Pediculus humanus (human body louse) PP03281 Pristionchus pacificus (nematode) 191512 Physcomitrella patens (moss) ENSPPYP00000012456 Pongo pygmaeus (orangutan) 72082 Phytophthora ramorum (sudden oak death pathogen) 108416 Phytophthora sojae (root rot pathogen) 819526 Populus trichocarpa (black cottonwood) ENSPTRP00000023475 Pan troglodytes (chimpanzee) ENSRNOP00000051977 Rattus norvegicus (norway rat) 4877462 Sorghum bicolor (sorghum) YPL209C Saccharomyces cerevisiae (budding yeast) Smp_135360 Schistosoma mansoni (trematode parasite) SPCC320.13c Schizosaccharomyces pombe (fission yeast) XP_001181990.1 Strongylocentrotus purpuratus (purple sea urchin) 30577 Trichoplax adhaerens (metazoa) XP_968329.1 Tribolium castaneum (red flour beetle) Tc00.1047053508817.80 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009848 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033875 Takifugu rubripes (pufferfish Takifugu) 3695.m00017 Tetrahymena thermophila (ciliate protozoa) 81997.m00106 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000026285 Xenopus tropicalis (frog) YALI0E34375g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/auroraa1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41446 modMine - Data generated by the modENCODE project. • FBgn0000147 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18556 NV16499 NV10752 LH11649 ISCW012666 ISCW002690 FBgn0243187 FBgn0230913 FBgn0220369 FBgn0215523 FBgn0210608 FBgn0207893 FBgn0193625 FBgn0190309 FBgn0178854 FBgn0166280 JGI_V11_308251 JGI_V11_111210 FBgn0079726 FBgn0075920 FBgn0159847 FBgn0156629 FBgn0146286 FBgn0146276 FBgn0146275 FBgn0024227 FBgn0130983 FBgn0121064 FBgn0110744 FBgn0102656 FBgn0094857 FBgn0091084 CPIJ020233 CPIJ007519 BGIBMGA006681 BGIBMGA002350 ACYPI008024 ACYPI004869 ACYPI003189 GB14418 GB11910 AGAP007855 AGAP001793 AAEL015523 AAEL015375 AAEL009880 AAEL006712 PB19770 PHUM019510 PHUM331400 GLEAN_01943 GLEAN_01817 REDfly - A database of transcriptional regulatory elements. • FBgn0000147
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	87A7-9/2 (Avramova and Tikhonov, 1999, Glover et al., 1995) aur (Shilova et al., 2006, Lott et al., 2011, Christensen et al., 2008.4.15, Lecuyer et al., 2007, Grieder et al., 2007, Georlette et al., 2007, Dobbelaere et al., 2008, Rickmyre et al., 2007, Cesario et al., 2006, Muse et al., 2007, Akimoto et al., 2005) aurA (Bettencourt-Dias et al., 2004, Giet et al., 2002, Berdnik and Knoblich, 2002, Giet and Glover, 2001, Andersen et al., 2007, Wang et al., 2006, Lee et al., 2006, Hutterer et al., 2006, Chia et al., 2008, Bowman et al., 2008, Wirtz-Peitz et al., 2008, Castellanos et al., 2008, Zhang et al., 2009, Wang et al., 2009, Ogawa et al., 2009, Sousa-Nunes et al., 2009, Wirtz-Peitz et al., 2008, Lerit and Gavis, 2011, Chang et al., 2010) AurA (Wirtz-Peitz et al., 2007, Pandey et al., 2007, Gomes et al., 2009, Chang et al., 2010) CG3068 (Berdnik and Knoblich, 2002, Morrison et al., 2000, Grieder et al., 2007, Dobbelaere et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) ck10 (Yang and Ballinger, 1994, Mlodzik et al., 1990) ck10 (Hu et al., 1998) l(3)87Ac (Deak et al., 1997, ) l(3)ck10 (Gausz et al., 1981, )
Name Synonym	A-type Aurora kinase (Towers and Sattelle, 2002) aurora (Ferree and Sullivan, 2006, Gregory et al., 2007, Kuhn et al., 2004, Rickmyre et al., 2007, Rickmyre et al., 2007, Muse et al., 2007, Specchia et al., 2010) Aurora (Silverman-Gavrila and Wilde, 2006, Lin, 2008, Petesch and Lis, 2008) Aurora A (Pines, 2006, Basto et al., 2006, Garcia et al., 2007, Barros et al., 2005, Wang et al., 2006, Zhang and Megraw, 2007, Pandey et al., 2007, Cesario et al., 2006, Graham et al., 2009) Aurora-A (Chia and Prokopenko, 2005, Chia and Yang, 2002, Terada et al., 2003, Morales-Mulia and Scholey, 2005, Lucas and Raff, 2007, Wirtz-Peitz et al., 2008, Ogawa et al., 2009) aurora A (Gergely, 2002, Gregory et al., 2007, Blagden and Glover, 2003, Chia et al., 2008, Zhang et al., 2009, Romé et al., 2010) AuroraA (Berdnik et al., 2001, Jankovics and Brunner, 2006, Gomes et al., 2009) auroraA (Hutterer et al., 2003, Giet and Glover, 2001, Hutterer et al., 2006) aurora-A (Berdnik and Knoblich, 2002, Andersen et al., 2007, Lee et al., 2006, Bowman et al., 2008) Aurora A kinase (Raff, 2002, Giet et al., 2002) Aurora Kinase (Still et al., 2004) early-A   fruhe2
Secondary FlyBase IDs
References ( 118 )
Generate a list of	All references relating to this gene ( 118 )
List References by type	Research paper  ( 59 ) Supplementary material  ( 7 ) Review  ( 25 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) Conference report  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 7 )
	Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Chang et al., 2010, Dev. Cell 19(5): 778--785 Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. [FBrf0212286] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Romé et al., 2010, J. Cell Biol. 189(4): 651--659 Aurora A contributes to p150glued phosphorylation and function during mitosis. [FBrf0210786] Specchia et al., 2010, Nature 463(7281): 662--665 Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons. [FBrf0209921] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...