Gene Dmel\aur

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General Information

Symbol

Dmel\aur

Species

D. melanogaster

Name

aurora

Annotation symbol

CG3068

Feature type

protein_coding_gene

FlyBase ID

FBgn0000147

Gene Model Status

Current

Stock availability

14 publicly available

Also Known As

aurA, 87A7-9/2, ck10, aur-A

Genomic Location

Chromosome (arm)

Recombination map

3-53

Cytogenetic map

87A3-87A3

Sequence location

3R:7,788,846..7,790,548 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene aurora is referred to in FlyBase by the symbol Dmel\aur (CG3068, FBgn0000147). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; mitotic centrosome separation; pole cell formation; establishment of spindle orientation; asymmetric protein localization; centrosome cycle; asymmetric protein localization involved in cell fate determination; regulation of neurogenesis; centrosome duplication; centrosome separation. 37 alleles are reported. The phenotypes of these alleles are annotated with: nervous system; organ system subdivision; multicellular structure; organ system; organelle; protein complex; somatic cell; intracellular organelle part; sensillum; spindle. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627325_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of aur. Gene sequence location is 3R:7788846..7790548.

User Contributed Data

Beta version, feedback welcome

External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

aur: aurora

Maternal-effect lethal. Embryos abnormal from nuclear cycle 9 onward. Multiple spindles assemble in long arrays with shared centrosomes. Polyploid nuclei develop with multiple centrosomes. Larval mitosis not investigated (Glover and Nusslein-Volhard).

l(3)87Ac

Hemizygotes pupate but form longer-than-normal pupae.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

Alleles

aur[190]

aur[Ubi-p63E.T:Avic\GFP]

Transgenic Constructs

P{Ubi-GFP-Aur-A}

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

87A3-87A3

Limits computationally determined from genome sequence between P{EP}Lk6^EP886 and P{PZ}svp⁰⁷⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-53

(Tearle and Nusslein-Volhard, 1987)

3-50.1

(Glover et al., 1995)

Left of (cM)

(Glover et al., 1995)

Right of (cM)

sens

(Glover et al., 1995)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\aur for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

aur-RA

FBtr0082483

NM_057401

1577

411

Additional Transcript Data & Comments

Reported size (kB)

1.6 (longest cDNA)

(Glover et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

aur-PA

FBpp0081957

46.2

411

10.09

NP_476749

AAF54723

Additional Polypeptide Data & Comments

Reported size (kDa)

421 (aa); 47 (kD predicted)

(Glover et al., 1995)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein kinase, catalytic domain (IPR000719)

Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290)

Serine/threonine-protein kinase, active site (IPR008271)

Protein kinase-like domain (IPR011009)

Protein kinase, ATP binding site (IPR017441)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

protein binding site

FBsf0000160710
3R:7,788,860..7,788,877

bound_moiety=BEAF-32A-XP
evidence=experimental

(Hart et al., 1997, Bergman et al., 2005)

protein binding site

FBsf0000160711
3R:7,788,808..7,788,821

bound_moiety=BEAF-32B-XP
evidence=experimental

(Hart et al., 1997, Bergman et al., 2005)

protein binding site

FBsf0000160712
3R:7,788,830..7,788,848

bound_moiety=BEAF-32B-XP
evidence=experimental

(Hart et al., 1997, Bergman et al., 2005)

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

organism

• yolk plasma | posterior

(Lecuyer et al., 2007)

embryonic stage 5

pole cell

(Lecuyer et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

• centrosome

(Giet et al., 2002)

Comment:expression assayed in cultured cells

Additional Descriptive Data

aur protein localizes to the centrosomes of S2 cells.

(Giet et al., 2002)

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		92.375
Larval Midgut		3.5
Larval Hindgut		8.7
Larval Malpighian Tubules		3.4
Larval Fat Body		37.8
Larval Salivary Gland		7.4
Larval Trachea		28.725
Larval Carcass		13.725
Adult Head		10.4
Adult Eye		20.575
Adult Brain		13.8
Adult Thoracic-Abdominal Ganglion		17.9
Adult Crop		9.9
Adult Midgut		5.7
Adult Hindgut		5.8
Adult Malpighian Tubules		4.8
Adult Fat Body		5.3
Adult Salivary Gland		4
Adult Heart		2.225
Adult VirginFemale Spermatheca		5.3
Adult InseminatedFemale Spermatheca		3.6
Adult Ovary		316.5
Adult Testis		231.6
Adult Male Accessory Gland		12.5
Adult Carcass		13.3
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	no informative data
NA	Eye	20.575
NA	Brain	13.8
92.375	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	17.9
NA	Crop	9.9
3.5	Midgut	5.7
8.7	Hindgut	5.8
3.4	Malpighian Tubules	4.8
no informative data	Fat Body	5.3
7.4	Salivary Gland	4
NA	Heart	2.225
28.725	Trachea	NA
NA	VirginFemale Spermatheca	5.3
NA	InseminatedFemale Spermatheca	3.6
NA	Ovary	316.5
NA	Testis	231.6
NA	Male Accessory Gland	no informative data
no informative data	Carcass	no informative data

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(41)
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		(44)
ovary, mated 4-day female		(34)
testis, mated 4-day male		(62)
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(41)
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		(44)
ovary, mated 4-day female		(34)
testis, mated 4-day male		(62)
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		41
central nervous system, larvae L3		7
central nervous system, pupae P8		2
head, virgin 1-day female		0
head, virgin 4-day female		1
head, virgin 20-day female		1
head, mated 1-day female		1
head, mated 4-day female		1
head, mated 20-day female		1
head, mated 1-day male		1
head, mated 4-day male		1
head, mated 20-day male		2
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		0
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		2
digestive system, 20-day adult		1
fat body, larvae L3 wandering		0
fat body, white prepupae		6
fat body, pupae P8		4
carcass, larvae L3 wandering		4
carcass, 1-day adult		1
carcass, 4-day adult		2
carcass, 20-day adult		2
ovary, virgin 4-day female		44
ovary, mated 4-day female		34
testis, mated 4-day male		62
accessory gland, mated 4-day male		7
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(89)
embryo 02-04hr		(47)
embryo 04-06hr		(53)
embryo 06-08hr		(56)
embryo 08-10hr		(44)
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		(41)
adult female 30day		(44)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(89)
embryo 02-04hr		(47)
embryo 04-06hr		(53)
embryo 06-08hr		(56)
embryo 08-10hr		(44)
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		(41)
adult female 30day		(44)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		89
embryo 02-04hr		47
embryo 04-06hr		53
embryo 06-08hr		56
embryo 08-10hr		44
embryo 10-12hr		16
embryo 12-14hr		8
embryo 14-16hr		7
embryo 16-18hr		4
embryo 18-20hr		2
embryo 20-22hr		4
embryo 22-24hr		6
larva L1		1
larva L2		1
larva L3 12hr old		1
larva L3 puffstage 1-2		6
larva L3 puffstage 3-6		10
larva L3 puffstage 7-9		12
white prepupae new		11
white prepupae 12hr		25
white prepupae 24hr		25
pupae 2d postWPP		15
pupae 3d postWPP		9
pupae 4d postWPP		9
adult male 01day		13
adult male 05day		24
adult male 30day		19
adult female 01day		17
adult female 05day		41
adult female 30day		44
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(46)
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		(29)
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		(48)
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		(28)
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		(37)
mixed discs ML-DmD4-c1		(31)
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(46)
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		(48)
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		(37)
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		46
Schneider line 2 Sg4		23
embryonic 1182-4H		20
embryonic GM2		10
embryonic Kc167		13
embryonic S1		29
embryonic S3		21
leg disc CME L1		14
wing disc CME-W2		15
wing disc ML-DmD8		24
wing disc ML-DmD9		26
wing disc ML-DmD16-c3		19
wing disc ML-DmD21		48
wing disc ML-DmD32		23
haltere disc ML-DmD17-c3		28
eye-antennal disc ML-DmD11		17
antennal disc ML-DmD20-c5		37
mixed discs ML-DmD4-c1		31
CNS ML-DmBG1-c1		21
CNS ML-DmBG2-c2		23
tumorous blood cells mbn2		13
ovary fGS/OSS		15
ovary OSC		26
ovary OSS		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		(28)
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		4
cold shock, 4-day adult		2
heat shock, 4-day adult		10
Cadmium 50 mM 6 hrs, larvae L3		4
Cadmium 50 mM 12 hrs, larvae L3		5
Cadmium 50 mM 48 hrs, 4-day adult		10
Cadmium 100 mM 48 hrs, 4-day adult		21
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		2
Zinc 4.5 mM 48 hrs, 4-day adult		8
Ethanol 2.5% 3 hrs, larvae L3		28
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		3
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		22
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		22
Paraquat 10 mM 48 hrs, 4-day adult		17
Rotenone 2 μg 12 hrs, larvae L3		3
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

LD16949

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0000147

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG3068-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | maternal effect | recessive

aur¹

lethal | pupal stage

lethal | pupal stage (with aur³⁷)

aur^87Ac-3

lethal | pupal stage (with aur^87Ac-3)

aur³⁷

lethal | pupal stage (with Df(3R)M-Kx1)

aur³⁷

lethal | pupal stage (with Df(3R)P-58)

aur³⁷

lethal | pupal stage | recessive

partially lethal - majority die | recessive

aur^87Ac-1

Sterility

Allele

female sterile

aur^87Ac-6

female sterile (with aur³)

female sterile (with aur^87Ac-3)

aur³

female sterile (with aur^87Ac-4)

aur³

female sterile (with aur^87Ac-5)

aur³

female sterile | recessive

sterile

Other Phenotypes

Allele

endomitotic cell cycle defective

aur⁸⁸³⁹

mitotic cell cycle defective

mitotic cell cycle defective (with aur^87Ac-3)

aur^87Ac-5

mitotic cell cycle defective (with aur^87Ac-4)

aur^87Ac-5

mitotic cell cycle defective (with aur^87Ac-5)

mitotic cell cycle defective (with Df(3R)P-79)

aur^87Ac-5

mitotic cell cycle defective (with Df(3R)T-47)

aur^87Ac-5

mitotic cell cycle defective (with Df(3R)T-61)

mitotic cell cycle defective | maternal effect

aur³

mitotic cell cycle defective | recessive

aur¹

neuroanatomy defective

neuroanatomy defective (with aur³⁷)

aur^87Ac-3

neuroanatomy defective (with aur^87Ac-3)

aur³⁷

neuroanatomy defective | somatic clone

aur¹⁴⁶⁴¹

visible

aur³⁷

wild-type

Phenotype manifest in

Allele

aster

aur^dsRNA.cGa

aster & neuroblast & larva (with Df(3R)T-61)

aur^87Ac-5

centriole & neuroblast & larva | ectopic (with Df(3R)T-61)

aur^87Ac-5

centrosome

aur³⁷

centrosome & neuroblast & larva

aur^87Ac-5

centrosome & neuroblast & larva (with Df(3R)T-61)

aur^87Ac-5

centrosome | embryonic stage

aur^unspecified

embryonic/larval brain

embryonic/larval brain | larval stage (with aur³⁷)

aur^87Ac-3

embryonic/larval brain | larval stage (with aur^87Ac-3)

aur³⁷

embryonic/larval brain | third instar larval stage

aur⁸⁸³⁹

embryonic/larval central nervous system

aur⁸⁸³⁹

embryonic/larval neuroblast (with aur³⁷)

aur^87Ac-3

embryonic/larval neuroblast (with aur^87Ac-3)

aur³⁷

eo neuron (with aur³⁷)

aur^87Ac-3

eo neuron (with aur^87Ac-3)

aur³⁷

eo neuron (with Df(3R)M-Kx1)

aur³⁷

eo neuron (with Df(3R)P-58)

aur³⁷

eo neuron | somatic clone

aur³⁷

metaphase & condensed nuclear chromosome

aur^dsRNA.cGa

microtubule & neuroblast & larva (with Df(3R)T-61)

aur^87Ac-5

microtubule | maternal effect

aur³

mitotic cell cycle

aur^unspecified

mitotic metaphase & larval brain

aur^87Ac-5

mitotic metaphase & larval brain (with Df(3R)P-79)

aur^87Ac-5

mitotic metaphase & larval brain (with Df(3R)T-47)

aur^87Ac-5

mitotic metaphase & larval brain (with Df(3R)T-61)

aur^87Ac-5

neuroblast

aur^{Ubi-p63E.T:Avic\GFP}

neuroblast | somatic clone | supernumerary

aur¹⁴⁶⁴¹

neuroblast | supernumerary & brain

aur^87Ac-3

neuroblast | supernumerary & larva

neuroblast | supernumerary & larval brain

nucleus | embryonic stage

aur^unspecified

pole cell (with aur³)

aur^87Ac-3

pole cell (with aur^87Ac-3)

aur³

sensory mother cell | somatic clone

aur³⁷

socket | ectopic | somatic clone

aur³⁷

spindle

spindle & neuroblast & larva

spindle & sensory mother cell & pupa

aur¹⁴⁶⁴¹

subperineurial glial cell

aur⁸⁸³⁹

thecogen cell

aur³⁷

thecogen cell (with aur³⁷)

aur^87Ac-3

thecogen cell (with aur^87Ac-3)

aur³⁷

thecogen cell (with Df(3R)M-Kx1)

aur³⁷

thecogen cell (with Df(3R)P-58)

aur³⁷

tormogen cell | ectopic (with aur³⁷)

aur^87Ac-3

tormogen cell | ectopic (with aur^87Ac-3)

aur³⁷

tormogen cell | ectopic (with Df(3R)M-Kx1)

aur³⁷

tormogen cell | ectopic (with Df(3R)P-58)

aur³⁷

tormogen cell | ectopic | somatic clone

aur³⁷

trichogen cell | ectopic (with aur³⁷)

aur^87Ac-3

trichogen cell | ectopic (with aur^87Ac-3)

aur³⁷

trichogen cell | ectopic (with Df(3R)M-Kx1)

aur³⁷

trichogen cell | ectopic (with Df(3R)P-58)

aur³⁷

trichogen cell | ectopic | somatic clone

aur³⁷

Classical Alleles ( 21 )

For All Classical Alleles Show

Allele of aur	Class	Mutagen	Stocks	Known lesion
aur^87Ac-3	amorphic allele - genetic evidence	ethyl methanesulfonate	2	--
aur¹		ethyl methanesulfonate	2	--
aur^EY03490		P-element activity	1	Yes
aur^GS7173			1	Yes
aur^87Ac-5	neomorphic allele - genetic evidence, amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
aur¹⁴⁶⁴¹		ethyl methanesulfonate	0	Yes
aur¹⁷⁹⁶¹		ethyl methanesulfonate	0	Yes
aur¹⁹⁰			0	--
aur²		ethyl methanesulfonate	0	--
aur³⁷		ethyl methanesulfonate	0	Yes
aur³		ethyl methanesulfonate	0	Yes
aur^87Ac-1		ethyl methanesulfonate	0	--
aur^87Ac-2		ethyl methanesulfonate	0	--
aur^87Ac-4		ethyl methanesulfonate	0	--
aur^87Ac-6		ethyl methanesulfonate	0	--
aur⁸⁸³⁹		ethyl methanesulfonate	0	Yes
aur^ST70		P-element activity	0	Yes
aur^unspecified			0	--
aur^ZIII-2400			0	--
aur^ZIII-2973			0	--
aur^ZIII-5137			0	--

Alleles Carried on Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Allele of aur	Mutagen	Stocks	Known lesion
aur^{Scer\UAS.Exel}	in vitro construct - regulatory fusion	2	Yes
aur^GL01136	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
aur^GMR.Exel	in vitro construct - regulatory fusion	1	Yes
aur^HM04011	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
aur^HMS01511	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
aur^HMS02205	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
aur^KK100143	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
aur^+t16.2	in vitro construct - genomic fragment	0	Yes
aur^+t3.7	in vitro construct - genomic fragment	0	Yes
aur^+t9	in vitro construct - genomic fragment	0	Yes
aur^dsRNA.cGa	in vitro construct - RNAi	0	Yes
aur^dsRNA.cTa	in vitro construct - RNAi	0	Yes
aur^GD10117	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
aur^Scer\UAS.cWa	in vitro construct - regulatory fusion	0	Yes
aur^{Scer\UAS.L.T:Avic\GFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
aur^{Scer\UAS.T:Avic\GFP-S65T}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
aur^{Ubi-p63E.T:Avic\GFP}	in vitro construct - coding region fusion in vitro construct - regulatory fusion	0	Yes
aur^VI	in vitro construct - genomic fragment	0	Yes