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Gene Dmel\Axs

General Information
Symbol	Dmel\Axs	Species	D. melanogaster
Name	Abnormal X segregation	Annotation symbol	CG9703
Feature type	protein_coding_gene	FlyBase ID	FBgn0000152
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map	1-56
Cytogenetic map	15A1-15A1	Sequence location	X:16,574,122..16,577,928 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Abnormal X segregation is referred to in FlyBase by the symbol Dmel\Axs (CG9703, FBgn0000152). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: female meiosis chromosome segregation; meiotic spindle organization; distributive segregation. 15 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Anoctamin/TMEM 16. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640260_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Axs. Gene sequence location is X:16574122..16577928.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Axs: Aberrant X segregation (A.E. Zitron and S. Hawley) Dominant meiotic mutant that affects distributive pairing; disrupts meiotic segregation of non-exchange chromosomes in females. Has no effect on the frequency of exchange. Loss of function mutation at a dosage sensitive locus; Axs+ duplication can rescue mutation in trans. Specific to female meiosis. In Axs/Axs/Y females, X-chromosomes nondisjunction is accompanied by random disjunction of the Y rather than directed disjunction from the X's as observed in +/+/Y females. Axs homozygotes increase X nondisjunction many fold; parallel but lesser effects observed on autosomal disjunction.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15A1-15A1   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References 15A1-15A1     (Hawley, 1998.10.26)
Experimentally Determined Recombination Data
Location	1-56   1-54.9 (Whyte et al., 1993)
Left of (cM)	car f (Whyte et al., 1993, Kramer and Hawley, 2003)
Right of (cM)	v r (Whyte et al., 1993, Kramer and Hawley, 2003)
Notes	Not separated from f in 80 recombinants between v and car.
Gene Model & Products
Please see the GBrowse view of Dmel\Axs for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Atypical cDNA: retained intron (LP10412).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Axs-RA FBtr0074372  NM_057429   2575   646 Axs-RB FBtr0100417  NM_001038760   2913   255
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Axs-PA   FBpp0074146   75.2   646   8.31     NP_476777   AAF48644 Axs-PB   FBpp0099834   29.5   255   6.37     NP_001033849   ABC67187
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Anoctamin/TMEM 16 (IPR007632)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699241   AE014298 AAF48644   AE014298 ABC67187   AC022350   AF101361 AAD17897   AI296429   AI296485   AI519286   AY118348 AAM48377   BZ286423   CO279077   CZ479840   CZ481648   CZ481649
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O97132 Q2PDZ8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000152    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000152 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000152 expression level Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1244) embryo 02-04hr  (674) embryo 04-06hr  (654) embryo 06-08hr  (609) embryo 08-10hr  (673) embryo 10-12hr  (409) embryo 12-14hr  (203) embryo 14-16hr  (141) embryo 16-18hr  (158) embryo 18-20hr  (250) embryo 20-22hr  (351) embryo 22-24hr  (399) larva L1  (434) larva L2  (524) larva L3 12hr old  (831) larva L3 puffstage 1-2  (938) larva L3 puffstage 3-6  (1067) larva L3 puffstage 7-9  (1230) white prepupae new  (963) white prepupae 12hr  (637) white prepupae 24hr  (586) pupae 2d postWPP  (384) pupae 3d postWPP  (285) pupae 4d postWPP  (1186) adult male 01day  (734) adult male 05day  (607) adult male 30day  (592) adult female 01day  (876) adult female 05day  (771) adult female 30day  (720) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000152 expression level Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1244) embryo 02-04hr  (674) embryo 04-06hr  (654) embryo 06-08hr  (609) embryo 08-10hr  (673) embryo 10-12hr  (409) embryo 12-14hr  (203) embryo 14-16hr  141 embryo 16-18hr  (158) embryo 18-20hr  (250) embryo 20-22hr  (351) embryo 22-24hr  (399) larva L1  (434) larva L2  (524) larva L3 12hr old  (831) larva L3 puffstage 1-2  (938) larva L3 puffstage 3-6  (1067) larva L3 puffstage 7-9  (1230) white prepupae new  (963) white prepupae 12hr  (637) white prepupae 24hr  (586) pupae 2d postWPP  (384) pupae 3d postWPP  (285) pupae 4d postWPP  (1186) adult male 01day  (734) adult male 05day  (607) adult male 30day  (592) adult female 01day  (876) adult female 05day  (771) adult female 30day  (720) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1244 embryo 02-04hr    674 embryo 04-06hr    654 embryo 06-08hr    609 embryo 08-10hr    673 embryo 10-12hr    409 embryo 12-14hr    203 embryo 14-16hr    141 embryo 16-18hr    158 embryo 18-20hr    250 embryo 20-22hr    351 embryo 22-24hr    399 larva L1    434 larva L2    524 larva L3 12hr old    831 larva L3 puffstage 1-2    938 larva L3 puffstage 3-6    1067 larva L3 puffstage 7-9    1230 white prepupae new    963 white prepupae 12hr    637 white prepupae 24hr    586 pupae 2d postWPP    384 pupae 3d postWPP    285 pupae 4d postWPP    1186 adult male 01day    734 adult male 05day    607 adult male 30day    592 adult female 01day    876 adult female 05day    771 adult female 30day    720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000152    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000152 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval Malpighian tubules, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000152 expression level Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000152 expression level Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    46.725 Larval Midgut    24.2 Larval Hindgut    138 Larval Malpighian Tubules    103.8 Larval Fat Body    56.4 Larval Salivary Gland    176.8 Larval Trachea    123.15 Larval Carcass    163.15 Adult Head    37.4 Adult Eye    13 Adult Brain    34.2 Adult Thoracic-Abdominal Ganglion    52.9 Adult Crop    71.2 Adult Midgut    26.6 Adult Hindgut    79.8 Adult Malpighian Tubules    82.4 Adult Fat Body    11.8 Adult Salivary Gland no informative data Adult Heart    62.625 Adult VirginFemale Spermatheca    11.4 Adult InseminatedFemale Spermatheca    12.9 Adult Ovary    61.4 Adult Testis    9.3 Adult Male Accessory Gland    115 Adult Carcass    51.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    37.4   NA  Eye    13   NA  Brain    34.2   46.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52.9   NA  Crop    71.2   24.2  Midgut    26.6   138  Hindgut    79.8   103.8  Malpighian Tubules    82.4   56.4  Fat Body    11.8   176.8  Salivary Gland    no informative data   NA  Heart    62.625   123.15  Trachea    NA   NA  VirginFemale Spermatheca    11.4   NA  InseminatedFemale Spermatheca    12.9   NA  Ovary    61.4   NA  Testis    9.3   NA  Male Accessory Gland    115   163.15  Carcass    51.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9703-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AxsGD3397 Other Phenotypes Allele meiotic cell cycle defective (with Axsr1) Axsr2 meiotic cell cycle defective (with Axsr2) Axsr1 meiotic cell cycle defective | dominant AxsD meiotic cell cycle defective | female AxsD meiotic cell cycle defective | recessive Axsr2 Axsr3 meiotic cell cycle defective | semidominant AxsD visible, with Scer\GAL4pnr-MD237 AxsGD3397 Phenotype manifest in Allele meiosis & nuclear chromosome, with Scer\GAL4nos.UTR.T:Hsim\VP16 AxsD.Scer\UAS.P\T meiosis & nuclear chromosome & spindle, with Scer\GAL4nos.UTR.T:Hsim\VP16 AxsD.Scer\UAS.P\T meiosis & nuclear chromosome | female AxsD mesothoracic tergum, with Scer\GAL4pnr-MD237 AxsGD3397 trichogen cell, with Scer\GAL4pnr-MD237 AxsGD3397
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Axs Class Mutagen Stocks Known lesion AxsD antimorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Axse02030 piggyBac transposase 1 -- AxsEY00887 P-element activity 1 -- Axse03891 piggyBac transposase 0 -- Axsr1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Axsr2 loss of function allele ethyl methanesulfonate 0 Yes Axsr3 loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Axs Class Mutagen Stocks Known lesion AxsGD3397 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AxsKK103665 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AxsD.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes AxsD.Scer\UAS in vitro construct - regulatory fusion 0 Yes AxsScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes AxsScer\UAS.P\T.cKa in vitro construct - regulatory fusion 0 Yes AxsScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes AxsScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;2)r+75c (Whyte et al., 1993) Dp(1;4)81j6c (Whyte et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3397} NA P{KK103665} NA P{UAS-Axs.D} NA P{UAS-Axs.EGFP} NA P{UAS-Axs.Myc} NA P{UAS-Axs.WT} NA P{UASp-Axs.D} NA P{UASp-Axs.WT} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}AxsEY00887 NA miscellaneous insertions PBac{RB}Axse02030 NA PBac{RB}Axse03891 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
distributive segregation inferred from genetic interaction with ald (Whyte et al., 1993) inferred from genetic interaction with ncd (Whyte et al., 1993) inferred from mutant phenotype (Zitron and Hawley, 1989, Whyte et al., 1993) female meiosis chromosome segregation inferred from mutant phenotype (Whyte et al., 1993, Kramer and Hawley, 2003, Zitron and Hawley, 1989) meiotic spindle organization inferred from mutant phenotype (Kramer and Hawley, 2003)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Kramer and Hawley, 2003) endoplasmic reticulum inferred from direct assay (Kramer and Hawley, 2003) nuclear outer membrane inferred from direct assay (Kramer and Hawley, 2003) spindle inferred from direct assay (Kramer and Hawley, 2003)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
female meiosis chromosome segregation non-traceable author statement (Lindsley and Zimm, 1992)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Kramer and Hawley, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Axs allele Gene References AxsD lwr (Apionishev et al., 2001) unspecified ald
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58981 DroID - A comprehensive database of gene and protein interactions. • FBgn0000152 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32645
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21728 Dere\GG18235 Dgri\GH11928 Dmoj\GI15349 Dper\GL12944 Dpse\GA21976 Dsec\GM13377 Dsim\GD15734 Dvir\GJ19453 Dwil\GK19948 Dyak\GE15653
Curated drosophilid orthologs	Dpse\GA21976   Dsim\Axs (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010243-PA Aedes aegypti (mosquito) AGAP009776-PA Anopheles gambiae (mosquito) 75374 Branchiostoma floridae (lancelet) 78371 Branchiostoma floridae (lancelet) ENSBTAP00000011710 Bos taurus (bovine) CAGL0F04345g Candida glabrata (haploid yeast) ENSCINP00000007396 Ciona intestinalis (sea squirt) CPIJ006825 Culex pipens (mosquito) ENSCSAVP00000004603 Ciona savignyi (sedentary tunicate) 182211 Capitella spl (polychaete worm) DDB0189520 Dictyostelium discoideum (amoeba) 233883 Daphnia pulex (daphnia) ENSDARP00000094943 Danio rerio (zebra fish) ENSECAP00000000448 Equus caballus (horse) ENSGALP00000018747 Gallus gallus (chicken) 191881 Hypsipyla robusta (cedar shoot borer) ENSP00000379399 Homo sapiens (human) 220570 Lottia gigantea (owl limpet) ENSMMUP00000001380 Macaca mulatta (rhesus monkey) ENSMUSP00000045214 Mus musculus (house mouse) ENSORLP00000004532 Oryzias latipes (japanese killifish) PHUM001397-PA Pediculus humanus (human body louse) 111412 Physcomitrella patens (moss) ENSPPYP00000015622 Pongo pygmaeus (orangutan) ENSPTRP00000025530 Pan troglodytes (chimpanzee) ENSRNOP00000029074 Rattus norvegicus (norway rat) 5036520 Sorghum bicolor (sorghum) YBR086C Saccharomyces cerevisiae (budding yeast) Smp_123680 Schistosoma mansoni (trematode parasite) XP_001189301.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001189939.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001203225.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969407.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000732 Tetraodon nigroviridis (green spotted pufferfish) 7537 Thalassiosira pseudonana (marine diatom) ENSTRUP00000033974 Takifugu rubripes (pufferfish Takifugu) 3834.m00336 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047668 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233223 FBgn0221945 FBgn0206596 FBgn0187395 FBgn0168308 JGI_V11_233883 JGI_V11_69282 FBgn0081961 FBgn0150550 FBgn0138098 FBgn0119407 FBgn0110451 FBgn0098728 CPIJ006825 AGAP009776 AAEL010243 PHUM136530 GLEAN_14620
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	14866 y1 w67c23 P{EPgy2}AxsEY00887 1637 y1 cv1 v1 AxsD car1/Dp(1;Y)y+/C(1)DX, y1 f1; svspa-pol
Harvard	- PBac{RB}Axse02030
VDRC	v100839 P{KK103665}VIE-260B v6137 w1118; P{GD3397}v6137/CyO
Genomic Clones ( 1 )
	BACR18G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP10412
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL08022 LD38815 LP10312
Other clones	EK133505
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32645
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Examination of meiotic prophase in Axs mutants reveals that while heterochromatic pairing may be a component of the mechanism of homologous segregation, it is not sufficient to guarantee proper disjunction of nonexchange homologs. (Dernburg et al., 1996) The Axs defect reflects a failure of the ability of achiasmate X chromosomes to separate and is not a consequence of heterologous pairings or alignments. Mutations at Axs disrupt meiotic spindle formation. The Axs locus has no detectable function in male meiosis. (Whyte et al., 1993) Mutations at Axs are specific to female meiosis and disrupt meiotic spindle formation, affecting the segregation of non-exchange chromosomes. Mutant alleles increase the frequency of X and 4th chromosome non-disjunction.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057429 NM_001038760 RefSeq (Proteins) • NP_476777 NP_001033849 DDBJ / EMBL / GenBank • AAD17897 AAF48644 AAF48644.1 AAM48377 ABC67187 AC022350 AF101361 AI296485 AY118348 BZ286423 CZ479840 CZ481648 CZ481649 Entrez Gene - A searchable database of RefSeq genes. • 32645 UniProtKB/TrEMBL • O97132 Q2PDZ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Anoctamin/TMEM 16 (IPR007632)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58981 DroID - A comprehensive database of gene and protein interactions. • FBgn0000152 DRSC - Results from RNAi screens. • FBgn0000152 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000152 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9703-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000152 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32645 InParanoid A subset of ortholog calls from InParanoid. • AAEL010243-PA Aedes aegypti (mosquito) AGAP009776-PA Anopheles gambiae (mosquito) 75374 Branchiostoma floridae (lancelet) 78371 Branchiostoma floridae (lancelet) ENSBTAP00000011710 Bos taurus (bovine) CAGL0F04345g Candida glabrata (haploid yeast) ENSCINP00000007396 Ciona intestinalis (sea squirt) CPIJ006825 Culex pipens (mosquito) ENSCSAVP00000004603 Ciona savignyi (sedentary tunicate) 182211 Capitella spl (polychaete worm) DDB0189520 Dictyostelium discoideum (amoeba) 233883 Daphnia pulex (daphnia) ENSDARP00000094943 Danio rerio (zebra fish) ENSECAP00000000448 Equus caballus (horse) ENSGALP00000018747 Gallus gallus (chicken) 191881 Hypsipyla robusta (cedar shoot borer) ENSP00000379399 Homo sapiens (human) 220570 Lottia gigantea (owl limpet) ENSMMUP00000001380 Macaca mulatta (rhesus monkey) ENSMUSP00000045214 Mus musculus (house mouse) ENSORLP00000004532 Oryzias latipes (japanese killifish) PHUM001397-PA Pediculus humanus (human body louse) 111412 Physcomitrella patens (moss) ENSPPYP00000015622 Pongo pygmaeus (orangutan) ENSPTRP00000025530 Pan troglodytes (chimpanzee) ENSRNOP00000029074 Rattus norvegicus (norway rat) 5036520 Sorghum bicolor (sorghum) YBR086C Saccharomyces cerevisiae (budding yeast) Smp_123680 Schistosoma mansoni (trematode parasite) XP_001189301.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001189939.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001203225.1 Strongylocentrotus purpuratus (purple sea urchin) XP_969407.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000732 Tetraodon nigroviridis (green spotted pufferfish) 7537 Thalassiosira pseudonana (marine diatom) ENSTRUP00000033974 Takifugu rubripes (pufferfish Takifugu) 3834.m00336 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047668 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32645 modMine - Data generated by the modENCODE project. • FBgn0000152 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233223 FBgn0221945 FBgn0206596 FBgn0187395 FBgn0168308 JGI_V11_233883 JGI_V11_69282 FBgn0081961 FBgn0150550 FBgn0138098 FBgn0119407 FBgn0110451 FBgn0098728 CPIJ006825 AGAP009776 AAEL010243 PHUM136530 GLEAN_14620
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	axs (Kramer and Hawley, 2005, Kramer et al., 2004, Hawley and Theurkauf, 1993) Axs (Mukai et al., 2006, Zitron and Hawley, 1989, Whyte et al., 1993, Apionishev et al., 2001, Anderson et al., 2009, Behm-Ansmant et al., 2006, Reis et al., 2011) CG9703 (Kramer and Hawley, 2003, Keleman et al., 2009.8.5)
Name Synonym	Aberrant X segregation   Abnormal X segregation (Mukai et al., 2006) abnormal X segregation (Flynn et al., 2007)
Secondary FlyBase IDs
	FBpp0074146 FBtr0074372
References ( 41 )
Generate a list of	All references relating to this gene ( 41 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 12 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 3 ) Interview  ( 1 )
Recent research papers ( 1 )
	Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...