Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Axs using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Axs in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Examination of meiotic prophase in Axs mutants reveals that while heterochromatic pairing may be a component of the mechanism of homologous segregation, it is not sufficient to guarantee proper disjunction of nonexchange homologs.
The Axs defect reflects a failure of the ability of achiasmate X chromosomes to separate and is not a consequence of heterologous pairings or alignments. Mutations at Axs disrupt meiotic spindle formation. The Axs locus has no detectable function in male meiosis.
Mutations at Axs are specific to female meiosis and disrupt meiotic spindle formation, affecting the segregation of non-exchange chromosomes. Mutant alleles increase the frequency of X and 4th chromosome non-disjunction.