FlyBase Gene Report: Dmel\baz

General Information

Symbol

Dmel\baz

Species

D. melanogaster

Name

bazooka

Annotation Symbol

CG5055

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000163

Gene Model Status

Stock Availability

28 publicly available

Gene Snapshot

bazooka (baz) encodes a scaffold protein that forms a complex with the products of par-6 and aPKC and with other cortical, cytoskeletal and regulatory proteins. It functions in cell polarization pathways in epithelial, neuronal and other cell types. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

Par3, Par-3, Bazooka/Par3, D-Par3, l(1)G0484

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:17,160,006..17,200,728 [+]

Recombination map

1-57

RefSeq locus

NC_004354 REGION:17160006..17200728

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (36 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables phosphatidic acid binding

inferred from direct assay

(Yu and Harris, 2012)

enables phosphatidylinositol binding

inferred from direct assay

(Krahn et al., 2010)

enables protein binding

inferred from physical interaction with FLYBASE:Traf4; FB:FBgn0026319

(Wang et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables phosphatidylinositol binding

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (26 terms)

Terms Based on Experimental Evidence (21 terms)

CV Term

Evidence

References

involved_in adherens junction organization

inferred from high throughput genetic interaction with UniProtKB:Q0KHR3,UniProtKB:Q9VJ04

(assigned by UniProt )

(Shao et al., 2010)

involved_in apical protein localization

inferred from mutant phenotype

(Sotillos et al., 2008)

involved_in asymmetric neuroblast division

inferred from mutant phenotype

(Izumi et al., 2004)

inferred from genetic interaction with FLYBASE:pins; FB:FBgn0040080

(Cai et al., 2003)

involved_in asymmetric protein localization involved in cell fate determination

inferred from mutant phenotype

(Wang et al., 2006)

involved_in axis elongation

inferred from direct assay

(Simões et al., 2010)

involved_in border follicle cell delamination

inferred from mutant phenotype

(McDonald et al., 2008)

involved_in border follicle cell migration

inferred from mutant phenotype

(Aranjuez et al., 2012, Pinheiro and Montell, 2004)

involved_in branching involved in open tracheal system development

inferred from mutant phenotype

(Jones and Metzstein, 2011)

involved_in establishment of apical/basal cell polarity

inferred from mutant phenotype

(Krahn et al., 2010, Hong et al., 2003)

involved_in establishment or maintenance of epithelial cell apical/basal polarity

inferred from mutant phenotype

(Harris and Peifer, 2005)

involved_in germ-band extension

inferred from mutant phenotype

(Zallen and Wieschaus, 2004)

involved_in germarium-derived oocyte fate determination

inferred from mutant phenotype

(Cox et al., 2001)

involved_in Malpighian tubule development

inferred from mutant phenotype

(Campbell et al., 2009)

involved_in negative regulation of filopodium assembly

inferred from mutant phenotype

(Georgiou and Baum, 2010)

involved_in oocyte anterior/posterior axis specification

inferred from mutant phenotype

(Doerflinger et al., 2010)

involved_in oocyte microtubule cytoskeleton organization

inferred from mutant phenotype

(Becalska and Gavis, 2010)

involved_in ovarian follicle cell-cell adhesion

inferred from mutant phenotype

(Abdelilah-Seyfried et al., 2003)

involved_in photoreceptor cell morphogenesis

inferred from mutant phenotype

(Chen et al., 2011)

involved_in regulation of establishment of planar polarity

inferred from mutant phenotype

(Simões et al., 2010)

inferred from genetic interaction with FLYBASE:dgo; FB:FBgn0086898

(Weber et al., 2012)

involved_in synapse assembly

inferred from mutant phenotype

(Ruiz-Canada et al., 2004)

involved_in zonula adherens assembly

inferred from mutant phenotype

(Harris and Peifer, 2004)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in establishment of cell polarity

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in establishment of centrosome localization

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in establishment or maintenance of epithelial cell apical/basal polarity

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in microtubule cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein localization

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Morais-de-Sá et al., 2010, Harris and Peifer, 2005)

located_in apical junction complex

inferred from direct assay

(Pilot et al., 2006)

located_in apical plasma membrane

inferred from direct assay

(David et al., 2010)

located_in cytoplasmic side of apical plasma membrane

inferred from direct assay

(Sotillos et al., 2008)

located_in spot adherens junction

inferred from direct assay

(Harris and Peifer, 2004)

located_in zonula adherens

inferred from direct assay

(Krahn et al., 2010, Krahn et al., 2010)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in adherens junction

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in apical junction complex

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in apical plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cell cortex

inferred from biological aspect of ancestor with PANTHER:PTN001046835

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

baz: bazooka

Homozygous lethal, large dorsal and ventral hole in embryo. Homozygous baz germ-line clones undergo oogenesis, but the heterozygous progeny produced display major reductions in viability (Wieschaus and Noell).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

4

Please see the JBrowse view of Dmel\baz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.47

Gene model reviewed during 6.11

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0074388

6762

1464

FBtr0111000

10439

1520

FBtr0343763

6485

1499

FBtr0343764

10334

1485

Additional Transcript Data and Comments

Reported size (kB)

6.7 (northern blot)

(Kuchinke et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0074162

157.4

1464

9.18

FBpp0110299

163.6

1520

9.17

FBpp0310322

161.3

1499

8.95

FBpp0310323

159.8

1485

9.36

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1464 (aa)

(Kuchinke et al., 1998)

Comments

baz protein localizes to the anterior cytoplasm of stage 3 and 5 oocytes and does not overlap with par-1 protein.

(Vaccari and Ephrussi, 2002)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\baz using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

baz_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell | apical

(Kuchinke et al., 1998)

(Kuchinke et al., 1998)

neuroblast | apical

(Kuchinke et al., 1998)

Additional Descriptive Data

baz transcript is detected in early embryos and is expressed in a dynamic pattern during embryonic development. In gastrulating embryos, baz transcript is detected beneath the apical membrane in epithelial cells; later, a similar subcellular localization is detected in epithelial cells of the epidermis. In neuroblasts, expression is detected in a crest in the apical cytocortex (facing the epithelium).

(Kuchinke et al., 1998)

Marker for

Subcellular Localization

CV Term

cytoplasm | apical

(Kuchinke et al., 1998)

Polypeptide Expression

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

• cell cortex

(Benton and St. Johnston, 2003)

immunohistochemistry

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Ruiz-Canada et al., 2004)

• microtubule of presynaptic active zone

(Ruiz-Canada et al., 2004)

Comment: peribouton area

(Ruiz-Canada et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell | apical

(Kuchinke et al., 1998)

neuroblast | apical

(Kuchinke et al., 1998)

scolopidial neuron | restricted

(Rolls and Doe, 2004)

• apicolateral plasma membrane

(Morais-de-Sá et al., 2010)

• adherens junction

(Morais-de-Sá et al., 2010)

adult stage | female & oogenesis

follicle stem cell

(Kronen et al., 2014)

follicle cell | apical

(Kronen et al., 2014)

oogenesis stage S3

oocyte | anterior

• cytoplasm

(Vaccari and Ephrussi, 2002)

oogenesis stage S5

oocyte | anterior

• cytoplasm

(Vaccari and Ephrussi, 2002)

embryonic stage 13 -- 14

Malpighian tubule Type II cell

(Campbell et al., 2010)

Additional Descriptive Data

baz protein is distributed diffusely in follicle stem cells, and is localized to the apical domain of downstream follicle cells.

(Kronen et al., 2014)

In stage 13 embryos baz is expressed in Malpighian tubule Type II (stellate) cells, particularly those that contact the tubule lumen. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of baz as well as crb, shg, and dlg1.

(Campbell et al., 2010)

baz protein is detected at the apical cytocortex of epithelial cells such as the cells of the tracheal pit and epidermis. In neuroblasts, the protein is in a submembraneous crescent in the apical cytocortex. Expression is detected at metaphase but not at interphase.

(Morais-de-Sá et al., 2010, Kuchinke et al., 1998)

colocalizes with par-6 and aPKC presynaptically, and with par-6 in the postsynaptic peribouton area.

(Yu et al., 2004)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Morais-de-Sá et al., 2010, Harris and Peifer, 2005)

located_in apical junction complex

inferred from direct assay

(Pilot et al., 2006)

located_in apical plasma membrane

inferred from direct assay

(David et al., 2010)

located_in cytoplasmic side of apical plasma membrane

inferred from direct assay

(Sotillos et al., 2008)

located_in spot adherens junction

inferred from direct assay

(Harris and Peifer, 2004)

located_in zonula adherens

inferred from direct assay

(Krahn et al., 2010, Krahn et al., 2010)

Expression Deduced from Reporters

Reporter: P{PTT-GC}baz^CC01941

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female & oogenesis stage S9

• cell cortex | anterior & cytoplasm

(Jouette et al., 2019)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\baz in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\baz

View exonic expression by tissue for Dmel\baz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000163

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5055-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5055

Flygut - An atlas of the Drosophila adult midgut

FBgn0000163

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 43 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 90 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of baz

Transgenic constructs containing regulatory region of baz

Deletions and Duplications ( 23 )

Disrupted in

Duplicated in

(McKim et al., 1996, Eberl and Hilliker, 1988)

(McKim et al., 1996)

(McKim et al., 1996, Eberl and Hilliker, 1988, Wieschaus et al., 1984)

(McKim et al., 1996)

(McKim et al., 1996)

Not disrupted in

(McKim et al., 1996)

(McKim et al., 1996)

(Tearle and Nusslein-Volhard, 1987)

Dp(1;4)exd^82b26c

(Tearle and Nusslein-Volhard, 1987)

Not duplicated in

(McKim et al., 1996)

(McKim et al., 1996)

(McKim et al., 1996)

Dp(1;Y)B^Ssog⁺y⁺

(Wickline and Lindsley, 1997)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

baz^{dsRNA.Sym.UAS}

lethal, with Scer\GAL4^Act5C.PU

baz^GD1384

lethal, with Scer\GAL4^e22c

baz^{S980A.UASp.mGFP6}

lethal, with Scer\GAL4^αTub84B.PL

lethal (with baz^358-12)

lethal (with baz^815-7)

baz^358-12

lethal (with baz^EH171)

baz^358-12

lethal | embryonic stage

baz^G0484

lethal | larval stage

baz^G0484

lethal | recessive

lethal - all die before end of embryonic stage

baz⁴

lethal - all die before end of embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

baz^{S980A.UASp.mGFP6}

lethal - all die before end of embryonic stage | recessive

partially lethal - majority die, with Scer\GAL4^{VP16.mat.αTub67C}

baz^UAS.cSa.GFP

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

baz^GD1384

viable, with Scer\GAL4^477w-

baz^UAS.mEosFP

viable, with Scer\GAL4^Mef2.PR

baz^GD1384

viable, with Scer\GAL4^pnr-MD237

baz^GD1384

viable, with Scer\GAL4^tin.CΔ4

baz^GD1384

Sterility

Allele

female sterile | germline clone

baz^358-12

baz^EY09846

Other Phenotypes

Allele

cell migration defective

cell polarity defective

cell polarity defective | somatic clone

baz^EH171

cell shape defective

baz⁴

cell shape defective, with Scer\GAL4^CY2

baz^{S151A.S1085A.UASp.GFP}

cell shape defective | somatic clone

baz^815-8

increased cell death, with Scer\GAL4^da.G32

baz^{S980A.UAS.GFP}

neuroanatomy defective

baz⁴

neuroanatomy defective | larval stage, with Scer\GAL4^C57

neurophysiology defective | larval stage, with Scer\GAL4^C57, baz^815-8

baz^{dsRNA.cRa.UAS}

neurophysiology defective | larval stage, with Scer\GAL4^C57, baz^{dsRNA.cRa.UAS}

baz^815-8

neurophysiology defective | larval stage (with baz^815-8), with Scer\GAL4^C57

baz^{dsRNA.cRa.UAS}

neurophysiology defective | larval stage (with baz^{dsRNA.cRa.UAS}), with Scer\GAL4^C57

baz^815-8

planar polarity defective

some die during embryonic stage

baz⁴

some die during embryonic stage, with Scer\GAL4^{VP16.mat.αTub67C}

baz^UAS.cSa.GFP

some die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

baz^{S980A.UASp.mGFP6}

some die during embryonic stage | recessive

visible, with Scer\GAL4^pnr-MD237

baz^GD1384

Phenotype manifest in

Allele

baz⁴

actomyosin, with Scer\GAL4^332.3

baz^UAS.cPa

adherens junction

baz⁴

adherens junction | pupal stage | somatic clone

baz⁴

border follicle cell, with Scer\GAL4^c306

border follicle cell, with Scer\GAL4^slbo.2.6

border follicle cell, with Scer\GAL4^slbo.2.6, baz⁴

baz^{dsRNA.Sym.UAS}

border follicle cell, with Scer\GAL4^slbo.2.6, baz^{dsRNA.Sym.UAS}

baz⁴

border follicle cell, with Scer\GAL4^slbo.2.6, Scer\GAL4^upd1.PU

baz^{dsRNA.Sym.UAS}

border follicle cell | somatic clone

baz⁴

dorsal appendage | germline clone | maternal effect

dorsal appendage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

baz^{S980E.UASp.mGFP6}

egg | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

baz^{S151A.S1085A.UASp.GFP}

egg chamber | germline clone

embryo | dorsal

baz⁴

embryo | gastrula stage

baz⁴

embryo | ventral

baz⁴

embryonic/first instar larval cuticle

baz⁴

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS

baz^{S980A.UAS.GFP}

embryonic/first instar larval cuticle, with Scer\GAL4^{VP16.mat.αTub67C}

baz^UAS.cSa.GFP

embryonic/first instar larval cuticle | germline clone

baz⁴

embryonic/first instar larval cuticle | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

baz^{S980A.UASp.mGFP6}

embryonic/first instar larval cuticle | ventral

baz⁴

embryonic/larval cuticle

baz⁴

embryonic/larval neuromuscular junction, with Scer\GAL4^C57

embryonic abdominal segment | germline clone | maternal effect

baz^X-82

embryonic epidermis

embryonic epidermis, with Scer\GAL4^da.G32

baz^{S980A.UAS.GFP}

embryonic epidermis & spindle

baz^815-8

embryonic ganglion mother cell

baz^815-8

embryonic ganglion mother cell | germline clone

baz⁴

baz⁴

embryonic leading edge cell

baz^815-8

embryonic Malpighian tubule

baz⁴

embryonic neuroblast & spindle | germ-line clone

baz⁴

epithelial cell | germline clone

baz⁴

eye, with Scer\GAL4^GMR.PF

baz^UAS.cKa

eye | somatic clone

baz⁴

eye disc | pupal stage

eye photoreceptor cell & eye disc & pupa | somatic clone

baz⁴

eye photoreceptor cell & eye disc & pupa | somatic clone | cell non-autonomous

baz⁴

follicle cell, with Scer\GAL4^CY2

baz^{S151A.S1085A.UASp.GFP}

follicle cell, with Scer\GAL4^T155

baz^GD1384

follicle cell | ectopic | somatic clone

baz^EH171

follicle cell | germline clone

baz^unspecified

follicle cell | somatic clone

follicle cell | somatic clone, with Scer\GAL4^Tub.PU

baz^{S980A.UASp.mGFP6}

germ band | early extended germ band stage

baz^YD

germ band | gastrula stage

baz^YD

interommatidial cell | pupal stage | somatic clone | supernumerary

baz^815-8

macrochaeta, with Scer\GAL4^pnr-MD237

baz^GD1384

baz^X-82

microtubule, with Scer\GAL4^unspecified

baz^{S151A.S1085A.UASp.GFP}

microtubule | germline clone

baz^358-12

neuroblast | P-stage | somatic clone

baz⁴

NMJ bouton, with Scer\GAL4^C57

nurse cell | germline clone

baz^unspecified

nurse cell fusome | germline clone

baz^unspecified

ommatidium | somatic clone

baz⁴

oocyte, with Scer\GAL4^unspecified

baz^{S151A.S1085A.UASp.GFP}

oocyte & centrosome | germ-line clone

baz^815-8

oocyte & microtubule | germ-line clone

baz^815-8

oocyte | germline clone

baz^unspecified

baz^X-82

oocyte nucleus, with Scer\GAL4^{VP16.mat.αTub67C}

oocyte nucleus | germline clone

baz^358-12

photoreceptor cell & eye | somatic clone

baz⁴

plasma membrane, with Scer\GAL4^ap.PU

baz^UAS.cSa.GFP

presumptive embryonic/larval central nervous system

baz^815-8

presumptive embryonic/larval nervous system

baz⁴

spot adherens junction

baz⁴

terminal tracheal cell | somatic clone

trichogen cell | supernumerary, with Scer\GAL4^pnr-MD237

baz^GD1384

zonula adherens

zonula adherens | somatic clone

baz^EH171

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

11 of 15

No

Yes

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1

Hsap\SYNJ2BP-COX16

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

11 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (23)

10 of 13

Yes

Yes

9 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (16)

7 of 12

Yes

Yes

7 of 12

Yes

Yes

1 of 12

No

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (32)

10 of 15

Yes

Yes

6 of 15

No

Yes

5 of 15

No

Yes

4 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\LOC100535100

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Drer\si:dkey-276j7.2

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (22)

10 of 15

Yes

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919020L )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00008176

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500U3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY007310

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13773

Mayetiola destructor

Hessian fly

Mdes\Mdes005266

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007658

Anopheles darlingi

American malaria mosquito

Adar\ADAC008276

Anopheles gambiae

Malaria mosquito

Agam\AGAP000869

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003808

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02WD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006557

Danaus plexippus

Monarch butterfly

Dple\DPOGS213816-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016161

Apis florea

Little honeybee

Aflo\2941307268

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00184e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006266

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM257850

Rhodnius prolixus

Kissing bug

Rpro\RPRC004878

Rhodnius prolixus

Kissing bug

Rpro\RPRC001227

Cimex lectularius

Bed bug

Clec\CLEC000665

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003311

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04429

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02T6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011645

Ixodes scapularis

Black-legged tick

Isca\ISCW015964

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58977.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66848.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur03g03780

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_34788

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_31747

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04AU )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Par3ph2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Par3ph1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000020218

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (26)

Gene Symbol

Score

Source

Alignment

a

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, epithelial, Par-complex-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Pagliarini and Xu, 2003)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

ameliorates hematologic cancer

modeled by hop^Tum

(Bina et al., 2010)

ameliorates hematologic cancer

modeled by hop^Tum

(Bina et al., 2010)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PARD3; par-3 family cell polarity regulator

13 of 15

PARD3B; par-3 family cell polarity regulator beta

11 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot, cross-linking study, western blot

(Kullmann and Krahn, 2018)

anti tag coimmunoprecipitation, anti tag western blot

(Krahn et al., 2009)

anti tag coimmunoprecipitation, western blot

(Jouette et al., 2019)

anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy

(Padash Barmchi et al., 2016)

anti tag coimmunoprecipitation, western blot

(Sen et al., 2015)

anti bait coimmunoprecipitation, western blot

(Sen et al., 2015)

anti bait coimmunoprecipitation, western blot, anti tag western blot, two hybrid

(Krahn et al., 2009)

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(von Stein et al., 2005)

anti tag coimmunoprecipitation, anti tag western blot

(Sotillos et al., 2013)

pull down, western blot, autoradiography, anti tag coimmunoprecipitation

(Sotillos et al., 2013, Sotillos et al., 2008)

pull down, autoradiography

(Mathew et al., 2011, Wang et al., 2006)

anti bait coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography

(Wei et al., 2005)

anti bait coimmunoprecipitation, western blot

(Goh et al., 2013)

pull down, autoradiography

(Kolsch et al., 2007)

anti tag coimmunoprecipitation, anti tag western blot

(Silver et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot

(Banerjee et al., 2017)

anti bait coimmunoprecipitation, western blot, two hybrid, pull down, autoradiography

(Wei et al., 2005)

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Banerjee et al., 2017, Djiane et al., 2005)

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, pull down, autoradiography

(Schober et al., 1999, Wodarz et al., 1999)

anti tag coimmunoprecipitation, anti tag western blot

(Banerjee et al., 2017)

pull down, anti tag western blot

(Wirtz-Peitz et al., 2008)

anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Krahn et al., 2009)

pull down, western blot

(Wirtz-Peitz et al., 2008)

pull down, anti tag western blot, western blot, autoradiography, molecular weight estimation by staining, anti bait coimmunoprecipitation

(Holly et al., 2020, Morais-de-Sá et al., 2010, Wirtz-Peitz et al., 2008, Hutterer et al., 2004, Peterson et al., 2004, Betschinger et al., 2003, Petronczki and Knoblich, 2001)

pull down, anti tag western blot

(Wirtz-Peitz et al., 2008)

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down

(Koch et al., 2016, Sen et al., 2015, Krahn et al., 2010)

anti bait coimmunoprecipitation, western blot

(Bulgakova et al., 2013, Harris and Peifer, 2005)

anti tag coimmunoprecipitation, anti tag western blot

(Jouette et al., 2019)

nuclear magnetic resonance, predetermined participant, anti tag coimmunoprecipitation, western blot, two hybrid

(Beati et al., 2018)

anti bait coimmunoprecipitation, western blot

(Wang and Riechmann, 2007)

pull down, western blot

(Wasserscheid et al., 2007)

anti bait coimmunoprecipitation, western blot

(Wodarz et al., 1999)

anti tag coimmunoprecipitation, anti tag western blot

(Krahn et al., 2009)

anti tag coimmunoprecipitation, anti tag western blot

(Krahn et al., 2009)

coimmunoprecipitation, anti tag western blot

(Keder et al., 2015)

anti bait coimmunoprecipitation, western blot

(Casas-Tintó and Ferrús, 2019)

anti bait coimmunoprecipitation, western blot

(Bulgakova et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Chen et al., 2011)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Dietzl et al., 2007)

enhanceable

(Harris and Peifer, 2005)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

suppressible

(Krahn et al., 2010)

enhanceable

(Banerjee et al., 2017)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Pinheiro and Montell, 2004)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

suppressible

(Krahn et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(Shao et al., 2010)

enhanceable

(David et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Jiang et al., 2015)

suppressible

(Wirtz-Peitz et al., 2008)

enhanceable

(Weber et al., 2012)

suppressible

(Abdelilah-Seyfried et al., 2003)

enhanceable

(Zarnescu et al., 2005)

suppressible

(Müller et al., 2005)

suppressible

(Bina et al., 2010)

suppressible

(Wirtz-Peitz et al., 2008)

enhanceable

(Wirtz-Peitz et al., 2008)

enhanceable

(Banerjee et al., 2017)

enhanceable

(Pinheiro and Montell, 2004)

enhanceable

(Pagliarini and Xu, 2003)

enhanceable

(Gervais et al., 2008)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59031

DroID - A comprehensive database of gene and protein interactions.

FBgn0000163

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32703

MIST (genetic) - An integrated Molecular Interaction Database

baz

MIST (protein-protein) - An integrated Molecular Interaction Database

baz

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-57

Cytogenetic map

Sequence location

X:17,160,006..17,200,728 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

15F1-15F1

Limits computationally determined from genome sequence between P{EP}EP1337 and P{EP}baz^EP1446

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

15F-15F

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.12.2)

15E-15F

(Knust, 1998.11.17, Kuchinke et al., 1996)

Experimentally Determined Recombination Data

Location

1-57

(FlyBase, 2016)

1-57.4

(Comeron et al., 2012)

1-56.7

(Tearle and Nusslein-Volhard, 1987)

Left of (cM)

f

(Kuchinke et al., 1996)

Right of (cM)

sd

(Becalska and Gavis, 2010)

Notes

Stocks and Reagents

Stocks (28)

29037

w^* P{UAS-baz.GFP.S}1

3295

y¹ baz⁴/FM7a

65845

w^*; P{UASp-baz.C.GFP}attP2

65869

w^*; P{UASp-baz.shRNA}attP40

65844

w^*; P{UAS-baz::mCherry}attP40/CyO

84234

y¹ v¹; M{WKO.P5-G4}ZH-86Fb

12272

w^67c23 P{lacW}baz^G0484/FM7c

31522

y¹ v¹; P{TRiP.JF01078}attP2

31523

y¹ v¹; P{TRiP.JF01079}attP2

106963

y¹ baz⁴/FM7c

v2914

w¹¹¹⁸; P{GD1384}v2914

v2915

w¹¹¹⁸; P{GD1384}v2915

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000163

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000163

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32703

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kullmann and Krahn, 2018, Calero-Cuenca et al., 2016, Inaba et al., 2015, Shahab et al., 2015, Morais-de-Sá et al., 2010, Krahn et al., 2009, Ramachandran et al., 2009, Wirtz-Peitz et al., 2008, Yu et al., 2004, Wodarz et al., 1999, Kuchinke et al., 1998)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: baz l(1)G0484

(Peter et al., 2002)

Additional comments

"l(1)G0497" may affect "baz". "l(1)G0313" may affect "baz".

(Peter et al., 2002)

Other Comments

baz is required for cell rearrangement and spatially regulated contractile behavior during axis elongation.

(Simões et al., 2010)

The C-terminal domain of baz is necessary for baz planar polarity.

(Simões et al., 2010)

baz acts upstream of adherens junctions as epithelial polarity is established during cellularization.

(Harris and Peifer, 2004)

baz acts as a permissive factor during cell invasion in the follicle cells. baz function is dispensable fro cell invasion and motility but is required cell-autonomously in mediating cell adhesion within the migrating border cell cluster.

(Abdelilah-Seyfried et al., 2003)

baz is required for the establishment of apical-basal polarity in eye photoreceptors during early pupal stages.

(Hong et al., 2003)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: binucleate cells.

(Kiger et al., 2003)

baz is required for par-1 relocalization within the oocyte.

(Vaccari and Ephrussi, 2002)

baz, raps and dlg1 establish and maintain planar polarity in pI cells.

(Bellaiche et al., 2001)

baz and par-6 proteins are interdependent for their asymmetric localisation at the apical cell cortex of epithelial cells and neuroblasts in the embryo.

(Petronczki and Knoblich, 2001)

Apical localisation of insc protein in embryonic neuroblasts requires baz.

(Schober et al., 1999)

Localisation of insc protein depends on baz.

(Wodarz et al., 1999)

baz is likely to be part of a regulatory mechanism required to coordinate the axis of polarity of a cell with that of the embryo.

(Kuchinke et al., 1998)

Embryos mutant for arm and sdt baz double mutant embryos have very similar early phenotypes with respect to zonula adherens formation. Results suggest that early stages in the assembly of the zonula adherens are critical for the stability of the polarised blastoderm epithelium.

(Muller and Wieschaus, 1996)

A screen for X-linked genes that affect embryo morphology revealed baz.

(Eberl and Hilliker, 1988)

baz mutants display a large dorsal hole and ventral hole.

(Wieschaus et al., 1984)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32703

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000163

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

baz_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5055

Flygut - An atlas of the Drosophila adult midgut

FBgn0000163

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32703

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034318

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5055

modMine - A data warehouse for the modENCODE project

FBgn0000163

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KHR3

Linkouts

BioGRID - A database of protein and genetic interactions.

59031

DroID - A comprehensive database of gene and protein interactions.

FBgn0000163

DRSC - Results frm RNAi screens

FBgn0000163

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000163

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5055-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000163

FlyMine - An integrated database for Drosophila genomics

FBgn0000163

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

32703

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

baz

MIST (protein-protein) - An integrated Molecular Interaction Database

baz

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

BAZ

(Baril et al., 2014, Claret et al., 2014)

Baz

(Khoury and Bilder, 2020, Sharrock and Sanson, 2020, Bonello and Peifer, 2019, Brantley and Fuller, 2019, Hannaford et al., 2019, Link et al., 2019, Nunes de Almeida et al., 2019, Pütz, 2019, Zhang et al., 2019, Bellec et al., 2018, Bonello et al., 2018, Carmena, 2018, Wang et al., 2018, Choubey and Roy, 2017, Richardson and Portela, 2017, Trylinski et al., 2017, Ajduk and Zernicka-Goetz, 2016, Flores-Benitez and Knust, 2016, Koch et al., 2016, Luo et al., 2016, Moreira and Morais-de-Sá, 2016, Schimizzi et al., 2016, Soriano et al., 2016, Veeman and McDonald, 2016, Yadav et al., 2016, Yasugi and Nishimura, 2016, Bell et al., 2015, Campbell and Casanova, 2015, Dong et al., 2015, Flores-Benitez and Knust, 2015, Jiang et al., 2015, Lan et al., 2015, Ohno et al., 2015, Schweisguth, 2015, Wang et al., 2015, Claret et al., 2014, Kumichel and Knust, 2014, Mauri et al., 2014, Pichaud, 2014, Simões et al., 2014, Skwarek et al., 2014, Thomas and Strutt, 2014, Zhang et al., 2014, Chai et al., 2013, Chen and Zhang, 2013, Desai et al., 2013, Goh et al., 2013, Guillot and Lecuit, 2013, Haack et al., 2013, Morais-de-Sá and Sunkel, 2013, Noatynska et al., 2013, Pérez-Gómez et al., 2013, Sotillos et al., 2013, Yu and Guan, 2013, Andersen et al., 2012, Bosveld et al., 2012, Fichelson et al., 2012, Giagtzoglou et al., 2012, Guilgur et al., 2012, Gurudatta et al., 2012, Homem and Knoblich, 2012, Penalva and Mirouse, 2012, Sarpal et al., 2012, Sen et al., 2012, Tamada et al., 2012, Tepass, 2012, Zhou and Hong, 2012, Genevet and Tapon, 2011, Laplante and Nilson, 2011, Laprise, 2011, Laprise and Tepass, 2011, Mathew et al., 2011, Mukai et al., 2011, Nance and Zallen, 2011, Sun et al., 2011, Wang et al., 2011, Campbell et al., 2010, David et al., 2010, Gandille et al., 2010, Georgiou and Baum, 2010, Gervais and Casanova, 2010, Januschke and Gonzalez, 2010, Morais-de-Sá et al., 2010, Mukhopadhyay et al., 2010, Nilton et al., 2010, Simone and DiNardo, 2010, Walther and Pichaud, 2010, Zeng et al., 2010, Cabernard and Doe, 2009, Chabu and Doe, 2009, Fernandez-Gonzalez et al., 2009, Kessler and Müller, 2009, Kim et al., 2009, McGill et al., 2009, Roeth et al., 2009, Wang et al., 2009, Chabu and Doe, 2008, Denef et al., 2008, Horne-Badovinac and Bilder, 2008, Huang et al., 2008, Krahn and Wodarz, 2008, Li et al., 2008, Siller and Doe, 2008, Spasić et al., 2008, Speicher et al., 2008, Wirtz-Peitz et al., 2008, Xu et al., 2008, Yamashita and Fuller, 2008, Blankenship et al., 2007, Bonaccorsi et al., 2007, Chandraratna et al., 2007, Grzeschik et al., 2007, Harris and Peifer, 2007, Kolsch et al., 2007, Lee et al., 2007, Nam et al., 2007, Wang and Riechmann, 2007, Wirtz-Peitz et al., 2007, Balakireva et al., 2006, Blankenship et al., 2006, Lee et al., 2006, Lee et al., 2006, Nam and Choi, 2006, O'Reilly et al., 2006, Pilot et al., 2006, Schneider et al., 2006, Siegrist and Doe, 2006, Wang et al., 2006, Wang et al., 2006, Becam et al., 2005, David et al., 2005, Jafar-Nejad et al., 2005, Langevin et al., 2005, Le Bivic, 2005, Siegrist and Doe, 2005, Wang et al., 2005, Wei et al., 2005, Yamashita et al., 2005, Harris and Peifer, 2004, Wei et al., 2004, Wu and Beitel, 2004)

Baz/Par-3

(Fehon, 2006)

Baz/Par3

(Georgiou and Baum, 2010)

Bazooka

(Khadilkar and Tanentzapf, 2019, Osterfield et al., 2015, Bergstralh et al., 2013, Muha and Müller, 2013, Kelsom and Lu, 2012, Nakano and Takashima, 2012, Laprise, 2011, Wirtz-Peitz and Knoblich, 2006)

CG5055

(Hosono et al., 2015, Rosa-Ferreira et al., 2015, Haelterman et al., 2014, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Ni et al., 2008)

D-Par3

(Weber et al., 2012, Pichaud et al., 2006)

D-par3

(Pinal et al., 2006)

PAR-3

(Deng et al., 2020, Jouette et al., 2017, Gross et al., 2013, Li, 2013, Baffet et al., 2012, McKinley and Harris, 2012, Halbsgut et al., 2011, Krahn et al., 2010, McDonald et al., 2008, Solecki et al., 2006, Suzuki and Ohno, 2006, Harris and Peifer, 2005, Wei et al., 2005, Lecuit, 2004)

PAR3

(Jouette et al., 2019, Nakano and Takashima, 2012, Saini and Reichert, 2012, Baas et al., 2004)

baz

(Graves et al., 2020, Hinnant et al., 2020, Liu et al., 2020, Sun et al., 2020, Zheng et al., 2020, Balaji et al., 2019, Guan et al., 2019, Jiang et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Nelson et al., 2019, Silver et al., 2019, Singh et al., 2019, Beati et al., 2018, Sun and Stathopoulos, 2018, Zoranovic et al., 2018, Banerjee et al., 2017, Herzmann et al., 2017, Hsu and Drummond-Barbosa, 2017, Stessman et al., 2017, Aigouy and Le Bivic, 2016, Clandinin and Owens, 2016-, Liu et al., 2016, Padash Barmchi et al., 2016, Walther et al., 2016, Xu et al., 2016, Besson et al., 2015, Keder et al., 2015, Le Droguen et al., 2015, Osterfield et al., 2015, Sen et al., 2015, Zaessinger et al., 2015, Ashwal-Fluss et al., 2014, Haelterman et al., 2014, Jiang et al., 2014, Morais-de-Sá et al., 2014, Parsons et al., 2014, Razzell et al., 2014, Zhou et al., 2014, Bulgakova et al., 2013, Desai et al., 2013, Gross et al., 2013, Homem et al., 2013, Jauffred et al., 2013, Leibfried et al., 2013, Osterfield et al., 2013, Pickering et al., 2013, Andersen et al., 2012, Aranjuez et al., 2012, Hazelett et al., 2012, McKinley et al., 2012, Robertson et al., 2012, Speese et al., 2012, Weber et al., 2012, Chen et al., 2011, Goossens et al., 2011, Halbsgut et al., 2011, Jones and Metzstein, 2011, Li et al., 2011, Ohsawa et al., 2011, Rodrigues et al., 2011, Sawyer et al., 2011, Tio et al., 2011, Toku et al., 2011, Becalska and Gavis, 2010, Bina et al., 2010, Chang et al., 2010, David et al., 2010, Doerflinger et al., 2010, Duchi et al., 2010, Fichelson et al., 2010, Franz and Riechmann, 2010, Januschke and Gonzalez, 2010, Kitajima et al., 2010, Krahn et al., 2010, Krahn et al., 2010, Shao et al., 2010, Simões et al., 2010, Bottenberg et al., 2009, Courbard et al., 2009, Hazelett et al., 2009, Ramachandran et al., 2009, Southall and Brand, 2009, Fernandez-Minan et al., 2008, Georgiou et al., 2008, Harris and Tepass, 2008, Horne-Badovinac and Bilder, 2008, Leibfried et al., 2008, Llense and Martín-Blanco, 2008, O'Reilly et al., 2008, Pope and Harris, 2008, Wirtz-Peitz et al., 2008, Wirtz-Peitz et al., 2008, Atwood et al., 2007, Buszczak et al., 2007, Choi et al., 2007, Dietzl et al., 2007, Heger and Ponting, 2007, Hueber et al., 2007, Szafranski and Goode, 2007, Wang and Riechmann, 2007, Wasserscheid et al., 2007, Bayraktar et al., 2006, Djiane et al., 2006, Pinal et al., 2006, Suzuki and Ohno, 2006, Ahringer, 2005, Djiane et al., 2005, Harris and Peifer, 2005, Jafar-Nejad et al., 2005, Lipatov et al., 2005, Lu and Bilder, 2005, Wiggin et al., 2005, Zarnescu et al., 2005, Harris and Peifer, 2004, Hutterer et al., 2004, Rolls and Doe, 2004, Rath et al., 2002, Wodarz et al., 1999)

bazooka

(Sherrard and Fehon, 2015, Miles et al., 2011, Humbert et al., 2006)

dPar-3

(Skeath and Thor, 2003)

l(1)G0484

(Schäfer et al., 1999.12.2)

par-3

(Le Droguen et al., 2015, Bulgakova et al., 2012, Fichelson et al., 2010, Sotillos et al., 2008, Breuer et al., 2005, Gotta, 2005, Rodriguez-Boulan et al., 2004)

par3

(Osterfield et al., 2015, Sherrard and Fehon, 2015)

Name Synonyms

Baz

(Pichaud, 2018)

Bazooka

(Finegan and Bergstralh, 2020, Das Gupta and Narasimha, 2019, Saito et al., 2018, Schmidt and Grosshans, 2018, Curran et al., 2017, Gilmour et al., 2017, Harris, 2017, Kong et al., 2017, Yamamoto et al., 2017, Koch et al., 2016, Liu et al., 2016, Moreira and Morais-de-Sá, 2016, Soriano et al., 2016, Xu et al., 2016, Bell et al., 2015, Campbell and Casanova, 2015, Peterson and Krasnow, 2015, Sen et al., 2015, Parsons et al., 2014, Zhang et al., 2014, Bardet et al., 2013, Bulgakova et al., 2013, Chen and Zhang, 2013, Culurgioni and Mapelli, 2013, Desai et al., 2013, Enderle and McNeill, 2013, Goh et al., 2013, Gross et al., 2013, Wang et al., 2013, Yu and Guan, 2013, Couturier et al., 2012, Guilgur et al., 2012, McKinley and Harris, 2012, Sarpal et al., 2012, Zhou and Hong, 2012, Laplante and Nilson, 2011, Levayer et al., 2011, Li et al., 2011, Sun et al., 2011, David et al., 2010, Forster et al., 2010, Franz and Riechmann, 2010, Krahn et al., 2010, Morais-de-Sá et al., 2010, Nilton et al., 2010, Simões et al., 2010, Simone and DiNardo, 2010, Walther and Pichaud, 2010, Campbell et al., 2009, Chabu and Doe, 2009, Coumailleau et al., 2009, Kessler and Müller, 2009, Kim et al., 2009, Krahn et al., 2009, McGill et al., 2009, Ramachandran et al., 2009, Chia et al., 2008, Harris and Tepass, 2008, Horne-Badovinac and Bilder, 2008, Krahn and Wodarz, 2008, Leibfried et al., 2008, Li et al., 2008, Llense and Martín-Blanco, 2008, McDonald et al., 2008, Speicher et al., 2008, Wirtz-Peitz et al., 2008, Xu et al., 2008, Atwood et al., 2007, Blankenship et al., 2007, Bonaccorsi et al., 2007, Chandraratna et al., 2007, Kohsaka et al., 2007, Lecuit and Le Goff, 2007, Nam et al., 2007, Nam et al., 2007, Speicher et al., 2007, Wang and Riechmann, 2007, Wilson et al., 2007, Ataman et al., 2006, Blankenship et al., 2006, Choksi et al., 2006, Laprise et al., 2006, Muschalik et al., 2006, Nam and Choi, 2006, Pichaud et al., 2006, Pinal et al., 2006, Suzuki and Ohno, 2006, Wang et al., 2006, Becam et al., 2005, Margolis and Borg, 2005, Somers and Chia, 2005, Wei et al., 2005, Yamashita et al., 2005, Franchini et al., 2004, Harris and Peifer, 2004, Lecuit, 2004, Roegiers and Jan, 2004, von Stein et al., 2003)

Bazooka-Par3

(Lin, 2008)

Bazooka/Par-3

(Fehon, 2006)

Bazooka/Par3

(Ly et al., 2017, Sarpal et al., 2012)

bazooka

(Graves et al., 2020, Takeda et al., 2018, Herzmann et al., 2017, Ng et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Le Droguen et al., 2015, Ohno et al., 2015, Taniguchi et al., 2014, Zhou et al., 2014, Bulgakova et al., 2013, Desai et al., 2013, Aranjuez et al., 2012, Paré et al., 2012, Wang et al., 2012, Weber et al., 2012, Yu and Harris, 2012, Chen et al., 2011, Furman and Bukharina, 2011, Spindler and Hartenstein, 2011, Tio et al., 2011, Becalska and Gavis, 2010, Fichelson et al., 2010, Kitajima et al., 2010, Shao et al., 2010, Mummery-Widmer et al., 2009, Fernandez-Minan et al., 2008, Harris and Tepass, 2008, O'Reilly et al., 2008, Choi et al., 2007, Wasserscheid et al., 2007, Burnette et al., 2005, Harris and Peifer, 2005, Lu and Bilder, 2005, Rath et al., 2002, Knust, 1998.11.17, Kuchinke et al., 1997)

par-3

(Le Droguen et al., 2015)

Secondary FlyBase IDs

FBgn0040145
FBgn0042632

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (636)