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Gene Dmel\baz

General Information
Symbol	Dmel\baz	Species	D. melanogaster
Name	bazooka	Annotation symbol	CG5055
Feature type	protein_coding_gene	FlyBase ID	FBgn0000163
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	Par-3, PAR3, D-Par3, Bazooka
Genomic Location
Chromosome (arm)	X	Recombination map	1-56.7
Cytogenetic map	15F1-15F1	Sequence location	X:17,054,039..17,089,350 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bazooka is referred to in FlyBase by the symbol Dmel\baz (CG5055, FBgn0000163). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphatidylinositol binding; protein binding. There is experimental evidence for 21 unique biological process terms, many of which group under: anatomical structure development; cellular process involved in reproduction; biological regulation; cellular component organization or biogenesis; multicellular organismal reproductive process; cell division; localization; regulation of developmental process; establishment or maintenance of monopolar cell polarity; establishment of planar polarity; open tracheal system development; germ-band extension; adherens junction assembly; regulation of multicellular organismal development; regulation of cellular component organization. 120 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; portion of tissue; anchoring junction; somatic cell; non-connected developing system; nervous system; organ system subdivision; presumptive embryonic/larval nervous system; female germline cyst. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PDZ domain; Protein of unknown function DUF3534. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1629227_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of baz. Gene sequence location is X:17054039..17089350.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	baz: bazooka Homozygous lethal, large dorsal and ventral hole in embryo. Homozygous baz germ-line clones undergo oogenesis, but the heterozygous progeny produced display major reductions in viability (Wieschaus and Noell).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms negative regulation of filopodium assembly
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15F1-15F1   Limits computationally determined from genome sequence between P{EP}EP1337 and P{EP}bazEP1446
Experimentally Determined Cytological Location
Cytogenetic map Notes References 15F-15F   (determined by in situ hybridisation)   (Peter et al., 2002) 15F-15F   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.2) 15E-15F     (Knust, 1998.11.17) 15E-15F     (Kuchinke et al., 1996)
Experimentally Determined Recombination Data
Location	1-56.7 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)	f (Kuchinke et al., 1996)
Right of (cM)	sd (Becalska and Gavis, 2010)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\baz for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 DGC clone LD15989 appears problematic: incomplete CDS Current 3'UTR overlaps downstream blastopia{}148 transposon
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) baz-RA FBtr0074388  NM_078659   6384   1464 baz-RB FBtr0111000  NM_001042818   10164   1520
Additional Transcript Data & Comments
Reported size (kB)	6.7 (northern blot) (Kuchinke et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein baz-PA   FBpp0074162   157.4   1464   9.18     NP_523383   AAF48703 baz-PB   FBpp0110299   163.6   1520   9.17     NP_001036283   ABI30988
Additional Polypeptide Data & Comments
Reported size (kDa)	1464 (aa) (Kuchinke et al., 1998)
Comments	baz protein localizes to the anterior cytoplasm of stage 3 and 5 oocytes and does not overlap with par-1 protein. (Vaccari and Ephrussi, 2002)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) Protein of unknown function DUF3534 (IPR021922)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201577   AA247041   AA440897   AA541050   AE014298 AAF48703   AE014298 ABI30988   AI515401   AJ130871 CAA10224   AJ426969   AQ254775   AW942391   BP541586   BQ103541   BT003584 AAO39588   BT032834   BX035877   CL526156   CO266558   CO270191   CO278801   CO292495   CO297351   CO306758   CO311085   CO313291   CO316993   CO318173   CO319817   CO321258   CO321845   CO327388   CO327934   CO330922   CO331824   CO334039   CO340580   CZ482275   CZ490152   EC052510   EC064432   EC064755   EC066703   EC078542   EC085849   EC087646   EC088641   EC090382   EC090568   EC090826   EC201999   EC203390   EC203648   EC209346   EC212265   EC212706   EC214224   EC224130   EC225606   EC231784   EC233026   EC244930   EC246278   EC250114   EC250563   EC252937   EC253367   EC254465   EC259877   FL502747   GH942182   GH943916   GH946527   GH948425   GH950897   GH953934   GH956013   GH960251   GH961451   GH961476   GH961808   GH962172   GH966074   GH981198
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VX75 Q0KHR3 O96782 Q86NX9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell | apical   (Kuchinke et al., 1998)   (Kuchinke et al., 1998) neuroblast | apical   (Kuchinke et al., 1998)
Additional Descriptive Data
	baz transcript is detected in early embryos and is expressed in a dynamic pattern during embryonic development. In gastrulating embryos, baz transcript is detected beneath the apical membrane in epithelial cells; later, a similar subcellular localization is detected in epithelial cells of the epidermis. In neuroblasts, expression is detected in a crest in the apical cytocortex (facing the epithelium). (Kuchinke et al., 1998)
Marker for
Subcellular Localization
CV Term	cytoplasm | apical (Kuchinke et al., 1998)
Polypeptide Expression
distribution deduced from reporter or direct label Stage Tissue/Position (including subcellular localization) Reference adult stage | female   germline cell   • cell cortex (Benton and St. Johnston, 2003) immunohistochemistry Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   NMJ bouton   (Yu et al., 2004) motor neuron   • microtubule of presynaptic active zone (Yu et al., 2004) muscle cell   (Yu et al., 2004) Comment:peribouton area immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell | apical   (Kuchinke et al., 1998) neuroblast | apical   (Kuchinke et al., 1998)   stage S3 oocyte | anterior   • cytoplasm (Vaccari and Ephrussi, 2002) stage S5 oocyte | anterior   • cytoplasm (Vaccari and Ephrussi, 2002)
Additional Descriptive Data
	baz protein is detected at the apical cytocortex of epithelial cells such as the cells of the tracheal pit and epidermis. In neuroblasts, the protein is in a submembraneous crescent in the apical cytocortex. Expression is detected at metaphase but not at interphase. (Kuchinke et al., 1998) colocalizes with par-6 and aPKC presynaptically, and with par-6 in the postsynaptic peribouton area. (Yu et al., 2004)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
adherens junction inferred from direct assay (Harris and Peifer, 2005, Morais-de-Sá et al., 2010) apical junction complex inferred from direct assay (Pilot et al., 2006) spot adherens junction inferred from direct assay (Harris and Peifer, 2004) zonula adherens inferred from direct assay (Krahn et al., 2010, Krahn et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval/adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    93.85 Larval Midgut    75.9 Larval Hindgut    109 Larval Malpighian Tubules    33 Larval Fat Body    6.4 Larval Salivary Gland    104.2 Larval Trachea    92.95 Larval Carcass    42.825 Adult Head    55.1 Adult Eye    60.7 Adult Brain    12.1 Adult Thoracic-Abdominal Ganglion    4.7 Adult Crop    126.5 Adult Midgut    70.8 Adult Hindgut    108.7 Adult Malpighian Tubules    28.5 Adult Fat Body    20.1 Adult Salivary Gland    167.1 Adult Heart    50.25 Adult VirginFemale Spermatheca    28 Adult InseminatedFemale Spermatheca    36.3 Adult Ovary    85.2 Adult Testis    19.5 Adult Male Accessory Gland    27.4 Adult Carcass    48.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    55.1   NA  Eye    60.7   NA  Brain    12.1   93.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.7   NA  Crop    126.5   75.9  Midgut    70.8   109  Hindgut    108.7   33  Malpighian Tubules    28.5   6.4  Fat Body    20.1   104.2  Salivary Gland    167.1   NA  Heart    50.25   92.95  Trachea    NA   NA  VirginFemale Spermatheca    28   NA  InseminatedFemale Spermatheca    36.3   NA  Ovary    85.2   NA  Testis    19.5   NA  Male Accessory Gland    27.4   42.825  Carcass    48.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    3 central nervous system, pupae P8    1 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    3 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    5 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    4 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    1 carcass, larvae L3 wandering    4 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    7 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    22 embryo 04-06hr    19 embryo 06-08hr    23 embryo 08-10hr    21 embryo 10-12hr    12 embryo 12-14hr    8 embryo 14-16hr    14 embryo 16-18hr    10 embryo 18-20hr    6 embryo 20-22hr    5 embryo 22-24hr    4 larva L1    2 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    4 white prepupae 24hr    5 pupae 2d postWPP    6 pupae 3d postWPP    3 pupae 4d postWPP    4 adult male 01day    4 adult male 05day    3 adult male 30day    3 adult female 01day    6 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    4 embryonic S1    3 embryonic S3    4 leg disc CME L1    3 wing disc CME-W2    3 wing disc ML-DmD8    2 wing disc ML-DmD9    3 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    9 wing disc ML-DmD32    2 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    4 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000163 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5055-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal bazFA50 bazGD21 lethal, with Scer\GAL4Act5C.PI bazdsRNA.Sym.Scer\UAS lethal, with Scer\GAL4Act5C.PU bazGD1384 lethal, with Scer\GAL4e22c bazS980A.Scer\UAS.P\T.T:Avic\GFP-m6 lethal, with Scer\GAL4αTub84B.PL bazdsRNA.Sym.Scer\UAS lethal (with baz358-12) baz815-7 bazEH171 lethal (with baz815-7) baz358-12 lethal (with bazEH171) baz358-12 lethal | embryonic stage baz4 bazG0484 lethal | embryonic stage | maternal effect, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazS980A.Scer\UAS.P\T.T:Avic\GFP-m6 lethal | embryonic stage | recessive baz1 baz2 baz3 baz4 baz692-4 baz692-44 baz692-59 baz815-7 baz815-8 bazEH171 bazEH647b bazEH747 bazR7 bazR21 bazYD lethal | larval stage bazG0484 lethal | recessive baz4 baz358-12 bazG0484 partially lethal - majority die | embryonic stage, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazScer\UAS.cSa.T:Avic\GFP viable bazCC01941 bazEY09846 viable, with Scer\GAL4477w- bazScer\UAS.T:Zzzz\EosFP-m viable, with Scer\GAL4pnr-MD237 bazGD1384 Sterility Allele female sterile | germline clone baz358-12 fertile bazEY09846 Other Phenotypes Allele cell migration defective bazFA50 bazGD21 cell polarity defective baz4 bazFA50 bazGD21 cell polarity defective | somatic clone bazEH171 cell shape defective baz4 increased cell death, with Scer\GAL4da.G32 bazS980A.Scer\UAS.T:Avic\GFP neuroanatomy defective baz4 neuroanatomy defective | larval stage, with Scer\GAL4C57 bazdsRNA.cRa.Scer\UAS bazGD1384 neurophysiology defective | larval stage, with Scer\GAL4C57, baz815-8 bazdsRNA.cRa.Scer\UAS neurophysiology defective | larval stage, with Scer\GAL4C57, bazdsRNA.cRa.Scer\UAS baz815-8 neurophysiology defective | larval stage (with baz815-8), with Scer\GAL4C57 bazdsRNA.cRa.Scer\UAS neurophysiology defective | larval stage (with bazdsRNA.cRa.Scer\UAS), with Scer\GAL4C57 baz815-8 planar polarity defective bazFA50 bazGD21 visible, with Scer\GAL4pnr-MD237 bazGD1384 Phenotype manifest in Allele adherens junction baz4 border follicle cell, with Scer\GAL4c306 bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP bazScer\UAS.P\T.T:Avic\GFP bazGD1384 border follicle cell, with Scer\GAL4slbo.2.6 bazdsRNA.Sym.Scer\UAS bazScer\UAS.cKa border follicle cell, with Scer\GAL4slbo.2.6, baz4 bazdsRNA.Sym.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6, bazdsRNA.Sym.Scer\UAS baz4 border follicle cell, with Scer\GAL4slbo.2.6, Scer\GAL4upd bazdsRNA.Sym.Scer\UAS border follicle cell | somatic clone baz4 bazEH171 bouton baz4 dorsal appendage | germline clone | maternal effect bazX-82 baz358-12 dorsal appendage | maternal effect, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazS980E.Scer\UAS.P\T.T:Avic\GFP-m6 egg | maternal effect, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP egg chamber | germline clone baz815-8 bazunspecified embryo bazFA50 bazGD21 embryo | dorsal baz4 embryo | ventral baz4 embryonic/first instar larval cuticle baz4 embryonic/first instar larval cuticle, with Scer\GAL4arm.PS bazS980A.Scer\UAS.T:Avic\GFP embryonic/first instar larval cuticle, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazScer\UAS.cSa.T:Avic\GFP embryonic/first instar larval cuticle | germline clone baz4 embryonic/first instar larval cuticle | maternal effect, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazS980A.Scer\UAS.P\T.T:Avic\GFP-m6 embryonic/first instar larval cuticle | ventral baz4 embryonic/larval cuticle baz4 embryonic/larval neuromuscular junction, with Scer\GAL4C57 bazGD1384 bazdsRNA.cRa.Scer\UAS embryonic abdominal segment | germline clone | maternal effect bazX-82 embryonic epidermis baz1 baz4 bazYD bazunspecified embryonic epidermis, with Scer\GAL4da.G32 bazS980A.Scer\UAS.T:Avic\GFP embryonic epidermis & spindle baz815-8 embryonic ganglion mother cell baz815-8 embryonic ganglion mother cell | germline clone baz4 embryonic head baz4 embryonic Malpighian tubule baz4 embryonic neuroblast & spindle | germ-line clone baz4 epithelial cell bazdsRNA.1944-3248 bazdsRNA.3623-4664 bazdsRNA.cLa epithelial cell | germline clone baz4 eye, with Scer\GAL4GMR.PF bazScer\UAS.cKa eye | somatic clone baz4 eye photoreceptor cell & eye disc & pupa | somatic clone baz4 eye photoreceptor cell & eye disc & pupa | somatic clone | cell non-autonomous baz4 follicle cell | ectopic | somatic clone bazEH171 follicle cell | germline clone bazunspecified follicle cell | somatic clone baz4 bazEH171 follicle cell | somatic clone, with Scer\GAL4tub.PU bazS980A.Scer\UAS.P\T.T:Avic\GFP-m6 germ band | early extended germ band stage bazYD germ band | gastrula stage bazYD late extended germ band embryo baz4 macrochaeta, with Scer\GAL4pnr-MD237 bazGD1384 microtubule bazX-82 microtubule, with Scer\GAL4unspecified bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP microtubule | germline clone baz358-12 neuroblast | P-stage | somatic clone baz4 NMJ bouton, with Scer\GAL4C57 bazGD1384 bazdsRNA.cRa.Scer\UAS nurse cell | germline clone bazunspecified nurse cell fusome | germline clone bazunspecified ommatidium | somatic clone baz4 oocyte, with Scer\GAL4unspecified bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP oocyte & centrosome | germ-line clone baz815-8 oocyte & microtubule | germ-line clone baz815-8 oocyte | germline clone bazunspecified oocyte nucleus bazX-82 oocyte nucleus, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP bazS980E.Scer\UAS.P\T.T:Avic\GFP-m6 oocyte nucleus | germline clone baz358-12 photoreceptor cell & eye | somatic clone baz4 presumptive embryonic/larval central nervous system baz815-8 presumptive embryonic/larval nervous system baz4 spot adherens junction baz4 terminal tracheal cell | somatic clone bazEH171 bazFA50 trichogen cell | supernumerary, with Scer\GAL4pnr-MD237 bazGD1384 zonula adherens baz4 bazYD zonula adherens | somatic clone bazEH171
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of baz Class Mutagen Stocks Known lesion baz4 ethyl methanesulfonate 3 Yes bazEH171 ethyl methanesulfonate 2 -- bazG0484 P-element activity 2 -- baz815-8 X ray 1 Yes bazd10637 1 -- baze04525 piggyBac transposase 1 -- bazEY09846 P-element activity 1 -- bazf07341 piggyBac transposase 1 -- bazNP3257 1 -- bazNP5047 1 -- baz1 ethyl methanesulfonate 0 -- baz2 ethyl methanesulfonate 0 -- baz358-12 0 Yes baz3 ethyl methanesulfonate 0 -- baz692-44 ethyl methanesulfonate 0 Yes baz692-4 ethyl methanesulfonate 0 -- baz692-59 ethyl methanesulfonate 0 -- baz815-7 X ray 0 -- bazCC01941 P-element activity 0 Yes bazd11396 0 -- bazEH647b ethyl methanesulfonate 0 -- bazEH747 ethyl methanesulfonate 0 Yes bazEP1446 P-element activity 0 -- bazFA50 0 Yes bazGD21 0 Yes bazGG01117 0 -- bazGG01459 0 -- bazGG01479 0 -- bazGG01835 0 -- bazR21 ethyl methanesulfonate 0 -- bazR7 ethyl methanesulfonate 0 -- bazunspecified 0 -- bazX-82 0 Yes bazXR-11 0 Yes bazYD 0 --
Alleles Carried on Transgenic Constructs ( 85 )
For All Alleles Carried on Transgenic Constructs Show
Allele of baz Class Mutagen Stocks Known lesion bazGD1384 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bazGL00654 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bazHMS01412 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bazHMS01992 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bazJF01078 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bazJF01079 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bazScer\UAS.cSa.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes bazC.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazdsRNA.10-987 in vitro construct - RNAi 0 Yes bazdsRNA.1944-3248 in vitro construct - RNAi 0 Yes bazdsRNA.3623-4664 in vitro construct - RNAi 0 Yes bazdsRNA.cCa in vitro construct - RNAi 0 Yes bazdsRNA.cFa in vitro construct - RNAi 0 Yes bazdsRNA.cLa in vitro construct - RNAi 0 Yes bazdsRNA.cRa.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes bazdsRNA.cWa in vitro construct - RNAi 0 Yes bazdsRNA.cYa in vitro construct - RNAi 0 Yes bazdsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes bazMtnA.PW in vitro construct - regulatory fusion 0 Yes bazN.Scer\UAS.P\T.T:Avic\GFP in vitro construct - deletion 0 Yes bazNIG.5055R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes bazPDZ1-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazPDZ1.5A.ΔPDZ2-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes bazS1085A.Scer\UAS.P\T.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes bazS151A.S1085A.Scer\UAS.P\T.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes bazS151A.Scer\UAS.P\T.T:Avic\GFP in vitro construct - amino acid replacement 0 Yes bazS980A.Scer\UAS.P\T.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes bazS980A.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes bazS980E.Scer\UAS.P\T.T:Avic\GFP-m6 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes bazS980E.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes bazScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes bazScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes bazScer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazScer\UAS.T:Zzzz\EosFP-m in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazUbi-p63E.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazX-82.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bazΔ1-317.S980A.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes bazΔ1-317.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1-904.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1-904Δ1073-1093.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1-904Δ1173-1193.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1-904Δ1222-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1-904Δ968-996.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1001-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1073-1093.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1097-1464.S980A.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes bazΔ1097-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1107-1464.Scer\UAS.T:Avic\GFP,T:PH-step in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1107-1464.Scer\UAS.T:Avic\GFP.T:Hsap\PLCD1 in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1173-1193.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1222-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1325-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ1461-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ968-996.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔ969-1464.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔaPKC.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔN.Scer\UAS.P\T.T:Avic\GFP in vitro construct - deletion 0 Yes bazΔOD+PDZ1.5A.ΔPDZ2-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes bazΔOD+ΔPDZ1+3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ1-2.PDZ3.5A.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes bazΔOD+ΔPDZ1-2.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ1-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ1.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ2-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ2.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD+ΔPDZ3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔOD.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ1+3.PDZ2.4A.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes bazΔPDZ1+3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ1-2.PDZ3.5A.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - amino acid replacement 0 Yes bazΔPDZ1-2.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ1-3+ΔaPKC.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - deletion 0 Yes bazΔPDZ1-3+ΔPIP.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - deletion 0 Yes bazΔPDZ1-3.S980A.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - coding region fusion 0 Yes bazΔPDZ1-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ1-3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔPDZ1.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ1.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔPDZ2-3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ2.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ2.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔPDZ3.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes bazΔPDZ3.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes bazΔPIP.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)815-6 (McKim et al., 1996) Df(1)B25 (Becalska and Gavis, 2010) Df(1)BK8 (McKim et al., 1996) Df(1)BK16 (McKim et al., 1996) Df(1)BK17 (McKim et al., 1996) Df(1)BK18 (McKim et al., 1996) Df(1)BK28 (McKim et al., 1996) Ts(1Lt;YLt)B17 (Muller et al., 1999) Ts(1Lt;YSt)B139 (Muller et al., 1999) Ts(1Lt;YSt)W23 (Muller et al., 1999)
Duplicated in	Dp(1;3)f+71b (Eberl and Hilliker, 1988, McKim et al., 1996) Dp(1;4)fK27 (McKim et al., 1996) Dp(1;4)r+l (Wieschaus et al., 1984, Eberl and Hilliker, 1988, McKim et al., 1996) Dp(1;4)rK20 (McKim et al., 1996) Dp(1;Y)W73 (McKim et al., 1996)
Not disrupted in	Df(1)B (McKim et al., 1996) Df(1)BK10 (McKim et al., 1996) Df(1)r-D17 (Tearle and Nusslein-Volhard, 1987) Dp(1;4)exd82b26c (Tearle and Nusslein-Volhard, 1987)
Not duplicated in	Dp(1;4)fK4 (McKim et al., 1996) Dp(1;4)fK7 (McKim et al., 1996) Dp(1;4)fK24 (McKim et al., 1996) Dp(1;Y)BSsog+y+ (Wickline and Lindsley, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1384} NA P{Sym-baz} NA P{TRiP.GL00654} NA P{TRiP.HMS01412} NA P{TRiP.HMS01992} NA P{TRiP.JF01078} NA P{TRiP.JF01079} NA P{UAS-baz.GFP.S} NA P{UAS-baz.K} NA P{UAS-baz.mEosFP} NA P{UAS-baz.RNAi.R} NA P{UAS-baz.S980A.GFP} NA P{UAS-baz.S980E.GFP} NA P{UAS-baz.Δ1-317.S980A.GFP} NA P{UAS-baz.Δ1097-1464.S980A.GFP} NA P{UAS-baz.ΔPDZ1-3.S980A.GFP} NA P{UASp-baz.C.GFP} NA P{UASp-baz.GFP} NA P{UASp-baz.N.GFP} NA P{UASp-baz.PDZ1-3.GFP} NA P{UASp-baz.PDZ1.5A.ΔPDZ2-3.GFP} NA P{UASp-baz.S151A.S1085A} NA P{UASp-baz.S151A} NA P{UASp-baz.S1085A} NA P{UASp-baz.X-82.GFP} NA P{UASp-baz.ΔaPKC.GFP} NA P{UASp-baz.ΔN.GFP} NA P{UASp-baz.ΔOD.GFP} NA P{UASp-baz.ΔOD+PDZ1.5A.ΔPDZ2-3.GFP} NA P{UASp-baz.ΔOD+ΔPDZ1-2.GFP} NA P{UASp-baz.ΔOD+ΔPDZ1-2.PDZ3.5A.GFP} NA P{UASp-baz.ΔOD+ΔPDZ1-3.GFP} NA P{UASp-baz.ΔOD+ΔPDZ1.GFP} NA P{UASp-baz.ΔOD+ΔPDZ1+3.GFP} NA P{UASp-baz.ΔOD+ΔPDZ2-3.GFP} NA P{UASp-baz.ΔOD+ΔPDZ2.GFP} NA P{UASp-baz.ΔOD+ΔPDZ3.GFP} NA P{UASp-baz.ΔPDZ1-2.GFP} NA P{UASp-baz.ΔPDZ1-2.PDZ3.5A.GFP} NA P{UASp-baz.ΔPDZ1-3.GFP} NA P{UASp-baz.ΔPDZ1-3+ΔaPKC.GFP} NA P{UASp-baz.ΔPDZ1-3+ΔPIP.GFP} NA P{UASp-baz.ΔPDZ1.GFP} NA P{UASp-baz.ΔPDZ1+3.GFP} NA P{UASp-baz.ΔPDZ1+3.PDZ2.4A.GFP} NA P{UASp-baz.ΔPDZ2-3.GFP} NA P{UASp-baz.ΔPDZ2.GFP} NA P{UASp-baz.ΔPDZ3.GFP} NA P{UASp-baz.ΔPIP.GFP} NA characterization construct P{NIG.5055R} NA P{Ubi-p63E-baz.mCherry} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}bazEP1446 NA P{EPgy2}bazEY09846 NA P{Mae-UAS.6.11}bazGG01117 NA P{Mae-UAS.6.11}bazGG01459 NA P{Mae-UAS.6.11}bazGG01479 NA P{Mae-UAS.6.11}bazGG01835 NA P{XP}bazd10637 NA P{XP}bazd11396 NA insertion of enhancer trap binary system P{GawB}bazNP3257 No P{GawB}bazNP5047 No miscellaneous insertions P{PTT-GC}bazCC01941 NA PBac{RB}baze04525 NA PBac{WH}bazf07341 NA insertion of enhancer trap P{lacW}bazG0484 No P{lacW}l(1)G0313G0313 No P{lacW}l(1)G0497G0497 No
Gene Ontology: Function, Process & Cellular Component ( 47 unique terms )
Terms Based on Experimental Evidence ( 27 terms )
Molecular Function
CV term Evidence References
phosphatidylinositol binding inferred from direct assay (Krahn et al., 2010) protein binding inferred from physical interaction with Traf4 (Wang et al., 2006)
Biological Process
CV term Evidence References
asymmetric neuroblast division inferred from genetic interaction with raps (Cai et al., 2003) inferred from mutant phenotype (Izumi et al., 2004) asymmetric protein localization involved in cell fate determination inferred from mutant phenotype (Wang et al., 2006) border follicle cell delamination inferred from mutant phenotype (McDonald et al., 2008) border follicle cell migration inferred from mutant phenotype (Pinheiro and Montell, 2004, Pinheiro and Montell, 2003) branching involved in open tracheal system development inferred from mutant phenotype (Jones and Metzstein, 2011) cell-cell adhesion involved in establishment of planar polarity inferred from direct assay (Simões et al., 2010) cytokinesis inferred from mutant phenotype (Kiger et al., 2003) establishment of apical/basal cell polarity inferred from mutant phenotype (Hong et al., 2003, Krahn et al., 2010) establishment or maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Harris and Peifer, 2005) germarium-derived oocyte fate determination inferred from mutant phenotype (Cox et al., 2001) germ-band extension inferred from mutant phenotype (Zallen and Wieschaus, 2004) Malpighian tubule development inferred from mutant phenotype (Campbell et al., 2009) negative regulation of filopodium assembly inferred from mutant phenotype (Georgiou and Baum, 2010) oocyte anterior/posterior axis specification inferred from mutant phenotype (Doerflinger et al., 2010) oocyte microtubule cytoskeleton organization inferred from mutant phenotype (Becalska and Gavis, 2010) ovarian follicle cell-cell adhesion inferred from mutant phenotype (Abdelilah-Seyfried et al., 2003) photoreceptor cell morphogenesis inferred from mutant phenotype (Chen et al., 2011) regulation of establishment of planar polarity inferred from genetic interaction with dgo (Weber et al., 2012) regulation of planar cell polarity pathway involved in axis elongation inferred from direct assay (Simões et al., 2010) synapse assembly inferred from mutant phenotype (Ruiz-Canada et al., 2004) zonula adherens assembly inferred from mutant phenotype (Harris and Peifer, 2004)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Harris and Peifer, 2005, Morais-de-Sá et al., 2010) apical junction complex inferred from direct assay (Pilot et al., 2006) spot adherens junction inferred from direct assay (Harris and Peifer, 2004) zonula adherens inferred from direct assay (Krahn et al., 2010, Krahn et al., 2010)
Terms Based on Predictions or Assertions ( 23 terms )
Molecular Function
CV term Evidence References
protein kinase C binding inferred from sequence or structural similarity with EMBL:AB005549 (FlyBase, 1992-)
Biological Process
CV term Evidence References
apical protein localization non-traceable author statement (Schaefer and Knoblich, 2001) asymmetric cell division traceable author statement (Cheah et al., 2000) asymmetric protein localization traceable author statement (Cheah et al., 2000) basal protein localization traceable author statement (Peng et al., 2000) cell-cell junction assembly non-traceable author statement (Bilder et al., 2002, Wedlich, 2002) establishment of mitotic spindle localization traceable author statement (Cheah et al., 2000) establishment or maintenance of cell polarity non-traceable author statement (Humbert et al., 2003) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Tepass et al., 2001, Bachmann et al., 2001) traceable author statement (Muller, 2003, Ahringer, 2003) establishment or maintenance of neuroblast polarity non-traceable author statement (Bachmann et al., 2001) establishment or maintenance of polarity of embryonic epithelium non-traceable author statement (Hong et al., 2001) germ-band extension traceable author statement (Baum, 2004) morphogenesis of an epithelium traceable author statement (Tepass et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) oocyte axis specification traceable author statement (Ahringer, 2003) zonula adherens assembly non-traceable author statement (Tepass et al., 2001) traceable author statement (Gibson and Perrimon, 2003, Muller, 2003)
Cellular Component
CV term Evidence References
apical cortex non-traceable author statement (Hong et al., 2001) traceable author statement (Ohshiro et al., 2000) apical part of cell non-traceable author statement (Peng et al., 2000) apical plasma membrane non-traceable author statement (Wedlich, 2002) traceable author statement (Gibson and Perrimon, 2003) apicolateral plasma membrane traceable author statement (Tepass et al., 2001) cell-cell adherens junction non-traceable author statement (Bilder et al., 2002) cell cortex traceable author statement (Bardin et al., 2004) subapical complex traceable author statement (Gibson and Perrimon, 2003, Medina et al., 2002)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
baz - sdt anti tag coimmunoprecipitation, anti tag western blot, pull down, anti bait coimmunoprecipitation, western blot (Krahn et al., 2010)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions baz allele Gene References baz4 Ras85D (Pagliarini and Xu, 2003) sdt (Tanentzapf and Tepass, 2003) bazEH171 dlg1 (Abdelilah-Seyfried et al., 2003) bazScer\UAS.cKa par-6 (Pinheiro and Montell, 2004) unspecified Gγ1 (Izumi et al., 2004) H (Mueller et al., 2005) rpr (Mueller et al., 2005) sdt (Hong et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59031 DroID - A comprehensive database of gene and protein interactions. • FBgn0000163 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32703 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KHR3
Orthologs
OrthoDB Orthologs (17) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6614PD Dipteran inclusive ortholog search EOG62V8Q8 Insect inclusive ortholog search EOG68PKF3 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6T4RN6
Orthologs in Drosophila Species (EOG6614PD)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\baz     Drosophila simulans   Dsim\GD17331 Y   Drosophila sechellia   Dsec\GM13492 Y   Drosophila erecta   Dere\GG19100 Y   Drosophila yakuba   Dyak\GE17646 Y   Drosophila ananassae   Dana\GF22322 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18624 Y   Drosophila persimilis   Dper\GL19872 Y   Drosophila willistoni   Dwil\GK25801 Y   Drosophila virilis   Dvir\GJ14885 Y   Drosophila mojavensis   Dmoj\GI16958 Y   Drosophila grimshawi   Dgri\GH12056 Y
Orthologs in non-Drosophila Dipterans (EOG62V8Q8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007658   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003808
Orthologs in non-Dipteran Insects (EOG68PKF3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\TC012087
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6T4RN6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009323gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009324gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD17331 Drosophila sechellia Dsec\GM13492 Drosophila erecta Dere\GG19100 Drosophila yakuba Dyak\GE17646 Drosophila ananassae Dana\GF22322 Drosophila pseudoobscura pseudoobscura Dpse\GA18624 Drosophila persimilis Dper\GL19872 Drosophila willistoni Dwil\GK25801 Drosophila virilis Dvir\GJ14885 Drosophila mojavensis Dmoj\GI16958 Drosophila grimshawi Dgri\GH12056
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	29037 w* P{UAS-baz.GFP.S}1 3295 y1 baz4/FM7a 12272 w67c23 P{lacW}bazG0484/FM7c 31522 y1 v1; P{TRiP.JF01078}attP2 31523 y1 v1; P{TRiP.JF01079}attP2 17613 y1 w67c23 P{EPgy2}bazEY09846
Harvard	- P{XP}bazd10637 - PBac{RB}baze04525 - PBac{WH}bazf07341
Kyoto	106963 y1 baz4/FM7c
VDRC	v2914 w1118; P{GD1384}v2914 v2915 w1118; P{GD1384}v2915
	More stocks available...
Genomic Clones ( 3 )
	BACR06G02 BACR15L12 BACR18O02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 72 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13977 LD15989
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD04932 LD06176 LD20835 LD47216
Other clones	10856 15372 35933 60338 60550 67691 72106 75358 82895 97416 100718 101190 106451 117696 123264 145387 149533 165107 166911 175943 180732 193219 214225.32 214277.42 214481.29 214501.26 274234 283235 CK01.127C.E8 DMG4-chrX.31.001.pred.a EC052510 EK097837 EK131710 EK146841 EK186519 EK200319 EK216756 EK223339 EK232074 EK252216 EK266538 EK270623 EK280935 EK290606 EK296438 EK301761 EK308727 EP06904 EP08302 EP10933 FGC003C04 RP004087239 RP004121746 RP004164022 RP004198888 RP004219043 RP004234914 RP004247014 RP004259086 RP004484117 RP004526888 RP004531813 RP004534683 RP004535697 RP004547573 UUGC0948
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000163 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32703
Antibody Information
	polyclonal (Morais-de-Sá et al., 2010, Yu et al., 2004, Krahn et al., 2009, Wirtz-Peitz et al., 2008, Ramachandran et al., 2009, Kuchinke et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: baz l(1)G0484 (Peter et al., 2002)
Additional comments	"l(1)G0497" may affect "baz". "l(1)G0313" may affect "baz". (Peter et al., 2002)
Other Comments
	baz is required for cell rearrangement and spatially regulated contractile behavior during axis elongation. (Simões et al., 2010) The C-terminal domain of baz is necessary for baz planar polarity. (Simões et al., 2010) baz acts upstream of adherens junctions as epithelial polarity is established during cellularization. (Harris and Peifer, 2004) baz acts as a permissive factor during cell invasion in the follicle cells. baz function is dispensable fro cell invasion and motility but is required cell-autonomously in mediating cell adhesion within the migrating border cell cluster. (Abdelilah-Seyfried et al., 2003) baz is required for the establishment of apical-basal polarity in eye photoreceptors during early pupal stages. (Hong et al., 2003) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) baz is required for par-1 relocalization within the oocyte. (Vaccari and Ephrussi, 2002) baz, raps and dlg1 establish and maintain planar polarity in pI cells. (Bellaiche et al., 2001) baz and par-6 proteins are interdependent for their asymmetric localisation at the apical cell cortex of epithelial cells and neuroblasts in the embryo. (Petronczki and Knoblich, 2001) Apical localisation of insc protein in embryonic neuroblasts requires baz. (Schober et al., 1999) Localisation of insc protein depends on baz. (Wodarz et al., 1999) baz is likely to be part of a regulatory mechanism required to coordinate the axis of polarity of a cell with that of the embryo. (Kuchinke et al., 1998) Embryos mutant for arm and sdt baz double mutant embryos have very similar early phenotypes with respect to zonula adherens formation. Results suggest that early stages in the assembly of the zonula adherens are critical for the stability of the polarised blastoderm epithelium. (Muller and Wieschaus, 1996) A screen for X-linked genes that affect embryo morphology revealed baz. (Eberl and Hilliker, 1988) baz mutants display a large dorsal hole and ventral hole. (Wieschaus et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078659 NM_001042818 RefSeq (Proteins) • NP_523383 NP_001036283 DDBJ / EMBL / GenBank • AA440897 AAF48703 AAO39588 ABI30988 AJ130871 AJ426969 AQ254775 AW942391 BT003584 CAA10224 CL526156 CZ482275 CZ490152 Entrez Gene - A searchable database of RefSeq genes. • 32703 UniProtKB/TrEMBL • O96782 Q0KHR3 Q9VX75 Q86NX9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) Protein of unknown function DUF3534 (IPR021922)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59031 DroID - A comprehensive database of gene and protein interactions. • FBgn0000163 DRSC - Results from RNAi screens. • FBgn0000163 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000163 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5055-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000163 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32703 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/bazoka1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32703 modMine - Data generated by the modENCODE project. • FBgn0000163 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q0KHR3
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	Baz (Wei et al., 2004, Wu and Beitel, 2004, Le Bivic, 2005, Wang et al., 2006, Nam et al., 2007, Pilot et al., 2006, O'Reilly et al., 2006, Siegrist and Doe, 2005, Wei et al., 2005, Harris and Peifer, 2004, Wirtz-Peitz et al., 2007, Wang and Riechmann, 2007, Schneider et al., 2006, Kolsch et al., 2007, Wang et al., 2006, Fichelson et al., 2012, Langevin et al., 2005, Lee et al., 2006, Lee et al., 2007, Becam et al., 2005, Krahn and Wodarz, 2008, Jafar-Nejad et al., 2005, Yamashita et al., 2005, Wang et al., 2005, Bonaccorsi et al., 2007, Yamashita and Fuller, 2008, Giagtzoglou et al., 2012, Nam and Choi, 2006, Balakireva et al., 2006, Gandille et al., 2010, David et al., 2005, Mukhopadhyay et al., 2010, Sun et al., 2011, Mukai et al., 2011, Tamada et al., 2012, Huang et al., 2008, Siegrist and Doe, 2006, Lee et al., 2006, Blankenship et al., 2006, Harris and Peifer, 2007, Denef et al., 2008, Mirouse et al., 2007, Li et al., 2008, Grzeschik et al., 2007, Siller and Doe, 2008, Speicher et al., 2008, Spasić et al., 2008, Chandraratna et al., 2007, Blankenship et al., 2007, Chabu and Doe, 2008, Campbell et al., 2010, Kessler and Müller, 2009, Sen et al., 2012, Wang et al., 2009, Chabu and Doe, 2009, Cabernard and Doe, 2009, Fernandez-Gonzalez et al., 2009, McGill et al., 2009, Kim et al., 2009, Wang et al., 2011, Roeth et al., 2009, Penalva and Mirouse, 2012, Morais-de-Sá et al., 2010, Gervais and Casanova, 2010, Xu et al., 2008, David et al., 2010, Walther and Pichaud, 2010, Januschke and Gonzalez, 2010, Simone and DiNardo, 2010, Nilton et al., 2010, Laplante and Nilson, 2011, Zeng et al., 2010, Horne-Badovinac and Bilder, 2008, Georgiou and Baum, 2010, Sarpal et al., 2012, Bosveld et al., 2012, Guilgur et al., 2012, Andersen et al., 2012, Mathew et al., 2011, Zhou and Hong, 2012, Gurudatta et al., 2012) baz (Hutterer et al., 2004, Djiane et al., 2006, Djiane et al., 2005, Ahringer, 2005, Wiggin et al., 2005, Lu and Bilder, 2005, Harris and Peifer, 2004, Harris and Peifer, 2005, Hazelett et al., 2012, Buszczak et al., 2007, Jafar-Nejad, 2005, Hueber et al., 2007, Jones and Metzstein, 2011, Dietzl et al., 2007, Zarnescu et al., 2005, Rolls and Doe, 2004, Suzuki and Ohno, 2006, Sawyer et al., 2011, Tio et al., 2011, Szafranski and Goode, 2007, Wasserscheid et al., 2007, Horne-Badovinac and Bilder, 2008, Li et al., 2011, Southall and Brand, 2009, Goossens et al., 2011, Halbsgut et al., 2011, Toku et al., 2011, O'Reilly et al., 2008, Wirtz-Peitz et al., 2008, Pope and Harris, 2008, Wang and Riechmann, 2007, Choi et al., 2007, Llense and Martín-Blanco, 2008, Bayraktar et al., 2006, Georgiou et al., 2008, Leibfried et al., 2008, Atwood et al., 2007, Harris and Tepass, 2008, Lipatov et al., 2005, Rath et al., 2002, Ramachandran et al., 2009, Ohsawa et al., 2011, Courbard et al., 2009, Bottenberg et al., 2009, Pinal et al., 2006, Wirtz-Peitz et al., 2008, Krahn et al., 2010, Franz and Riechmann, 2010, Becalska and Gavis, 2010, Doerflinger et al., 2010, Shao et al., 2010, Duchi et al., 2010, Bina et al., 2010, Fichelson et al., 2010, Chen et al., 2011, Januschke and Gonzalez, 2010, Krahn et al., 2010, Fernandez-Minan et al., 2008, Hazelett et al., 2009, Simões et al., 2010, Kitajima et al., 2010, Chang et al., 2010, McKinley et al., 2012, Leibfried et al., 2013, Robertson et al., 2012, Heger and Ponting, 2007, Weber et al., 2012, Andersen et al., 2012, Speese et al., 2012) Baz/Par-3 (Fehon, 2006) Baz/Par3 (Georgiou and Baum, 2010) Bazooka (Wirtz-Peitz and Knoblich, 2006) bazooka (Humbert et al., 2006) CG5055 (Ni et al., 2008, Ni et al., 2011.7.19, Ni et al., 2010.12.1) dPar-3 (Skeath and Thor, 2003) D-Par3 (Pichaud et al., 2006, Weber et al., 2012) D-par3 (Pinal et al., 2006) l(1)G0484 (Schaefer et al., 1999.12.2, ) Par-3 (Sotillos et al., 2004, Betschinger and Knoblich, 2004, Roegiers and Jan, 2004, Macara, 2004, Doe, 2001, Pilot et al., 2006, Chabu et al., 2007, Yamashita et al., 2005, Lecuit and Le Goff, 2007, Chabu and Doe, 2009, Franz and Riechmann, 2010, David et al., 2010, Zhou and Hong, 2012) par-3 (Rodriguez-Boulan et al., 2004, Breuer et al., 2005, Gotta, 2005, Sotillos et al., 2008, Fichelson et al., 2010) PAR3 (Baas et al., 2004) Par3 (Pilot et al., 2005, Gibson and Perrimon, 2003, Garcia-Mata and Burridge, 2007, Humbert et al., 2006, Speicher et al., 2007, Chia et al., 2008, Yamashita and Fuller, 2008, Levayer et al., 2011, Georgiou et al., 2008, Shao et al., 2010, Leatherman and Dinardo, 2010, Simone and DiNardo, 2010, Baffet et al., 2012, Georgiou and Baum, 2010, Guilgur et al., 2012) PAR-3 (Wei et al., 2005, Solecki et al., 2006, Harris and Peifer, 2005, Lecuit, 2004, Suzuki and Ohno, 2006, Halbsgut et al., 2011, McDonald et al., 2008, Krahn et al., 2010, Baffet et al., 2012)
Name Synonym	Bazooka (von Stein et al., 2003, Roegiers and Jan, 2004, Pichaud et al., 2006, Muschalik et al., 2006, Wang et al., 2006, Nam et al., 2007, Wilson et al., 2007, Wei et al., 2005, Harris and Peifer, 2004, Ataman et al., 2006, Speicher et al., 2007, Somers and Chia, 2005, Becam et al., 2005, Krahn and Wodarz, 2008, Harris and Tepass, 2008, Lecuit, 2004, Yamashita et al., 2005, Margolis and Borg, 2005, Bonaccorsi et al., 2007, Suzuki and Ohno, 2006, Lecuit and Le Goff, 2007, Chia et al., 2008, Nam and Choi, 2006, Krahn et al., 2009, Horne-Badovinac and Bilder, 2008, Li et al., 2011, Coumailleau et al., 2009, Levayer et al., 2011, Laprise et al., 2006, Blankenship et al., 2006, Choksi et al., 2006, Mirouse et al., 2007, Li et al., 2008, Wirtz-Peitz et al., 2008, Nam et al., 2007, Wang and Riechmann, 2007, Llense and Martín-Blanco, 2008, Speicher et al., 2008, Leibfried et al., 2008, McDonald et al., 2008, Atwood et al., 2007, Chandraratna et al., 2007, Blankenship et al., 2007, Kessler and Müller, 2009, Chabu and Doe, 2009, Ramachandran et al., 2009, Campbell et al., 2009, McGill et al., 2009, Forster et al., 2010, Kohsaka et al., 2007, Kim et al., 2009, Pinal et al., 2006, Morais-de-Sá et al., 2010, Krahn et al., 2010, Franz and Riechmann, 2010, Xu et al., 2008, David et al., 2010, Walther and Pichaud, 2010, Simone and DiNardo, 2010, Nilton et al., 2010, Laplante and Nilson, 2011, Simões et al., 2010, Franchini et al., 2004, Sun et al., 2011, Couturier et al., 2012, Guilgur et al., 2012, Zhou and Hong, 2012) bazooka (Knust, 1998.11.17, Kuchinke et al., 1997, Lu and Bilder, 2005, Harris and Peifer, 2005, Choi et al., 2007, Tio et al., 2011, Wasserscheid et al., 2007, Spindler and Hartenstein, 2011, O'Reilly et al., 2008, Harris and Tepass, 2008, Rath et al., 2002, Mummery-Widmer et al., 2009, Becalska and Gavis, 2010, Shao et al., 2010, Fichelson et al., 2010, Chen et al., 2011, Fernandez-Minan et al., 2008, Kitajima et al., 2010, Wang et al., 2012, Weber et al., 2012, Paré et al., 2012) Bazooka/Par-3 (Fehon, 2006) Bazooka/Par3 (Sarpal et al., 2012) Bazooka-Par3 (Lin, 2008)
Secondary FlyBase IDs
	FBgn0040145 FBgn0042632
References ( 419 )
Generate a list of	All references relating to this gene ( 419 )
List References by type	Research paper  ( 232 ) Supplementary material  ( 11 ) Review  ( 105 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 53 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 ) Interview  ( 1 )
Recent research papers ( 42 )
	Leibfried et al., 2013, Development 140(2): 362--371 A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. [FBrf0220348] Sotillos et al., 2013, Development 140(7): 1507--1516 Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. [FBrf0221056] Andersen et al., 2012, Dev. Biol. 363(1): 258--265 Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. [FBrf0217488] Baffet et al., 2012, Mol. Biol. Cell 23(18): 3591--3601 Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. [FBrf0219447] Bosveld et al., 2012, Science 336(6082): 724--727 Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway. [FBrf0218281] Couturier et al., 2012, Nat. Cell Biol. 14(2): 131--139 Endocytosis by Numb breaks Notch symmetry at cytokinesis. [FBrf0217937] Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898 Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Giagtzoglou et al., 2012, J. Cell Biol. 196(1): 65--83 dEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions. [FBrf0217836] Goulas et al., 2012, Cell Stem Cell 11(4): 529--540 The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. [FBrf0219511] Guilgur et al., 2012, Development 139(3): 503--513 Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells. [FBrf0217157] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] McKinley et al., 2012, J. Cell Sci. 125(5): 1177--1190 Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism. [FBrf0217991] Paré et al., 2012, PLoS ONE 7(5): e36254 The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers. [FBrf0218280] Penalva and Mirouse, 2012, Development 139(24): 4549--4554 Tissue-specific function of Patj in regulating the Crumbs complex and epithelial polarity. [FBrf0220038] Robertson et al., 2012, Development 139(18): 3432--3441 Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. [FBrf0219783] Sarpal et al., 2012, J. Cell Sci. 125(1): 233--245 Mutational analysis supports a core role for Drosophila α-Catenin in adherens junction function. [FBrf0217336] Sen et al., 2012, J. Cell Biol. 199(4): 685--698 Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity. [FBrf0219897] Speese et al., 2012, Cell 149(4): 832--846 Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. [FBrf0218749] Tamada et al., 2012, Dev. Cell 22(2): 309--319 Abl Regulates Planar Polarized Junctional Dynamics through β-Catenin Tyrosine Phosphorylation. [FBrf0217502] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Wang et al., 2012, Nature 484(7394): 390--393 Differential positioning of adherens junctions is associated with initiation of epithelial folding. [FBrf0218084] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Zhou and Hong, 2012, Development 139(16): 2891--2896 Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability. [FBrf0219035] Chen et al., 2011, PLoS ONE 6(1): e16127 Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822] Goossens et al., 2011, Development 138(8): 1595--1605 The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. [FBrf0213316] Halbsgut et al., 2011, Mol. Biol. Cell 22(22): 4373--4379 Apical-basal polarity in Drosophila neuroblasts is independent of vesicular trafficking. [FBrf0216808] Jones and Metzstein, 2011, Genetics 189(1): 153--164 A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. [FBrf0215238] Laplante and Nilson, 2011, J. Cell Biol. 192(2): 335--348 Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. [FBrf0212838] Levayer et al., 2011, Nat. Cell Biol. 13(5): 529--540 Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis. [FBrf0213654] Li et al., 2011, Fly 5(2): 81--87 Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis. [FBrf0213760] Mathew et al., 2011, Mol. Cell. Biol. 31(24): 4978--4993 Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. [FBrf0216703] Mukai et al., 2011, Mech. Dev. 128(7-10): 510--523 Innexin2 gap junctions in somatic support cells are required for cyst formation and for egg chamber formation in Drosophila. [FBrf0216750] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Sawyer et al., 2011, Mol. Biol. Cell 22(14): 2491--2508 A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. [FBrf0214396] Spindler and Hartenstein, 2011, Neural Dev. 6: 16 Bazooka mediates secondary axon morphology in Drosophila brain lineages. [FBrf0213838] Sun et al., 2011, Development 138(10): 1991--2001 Regulation of somatic myosin activity by Protein Phosphatase 1{beta} controls Drosophila oocyte polarization. [FBrf0213586] Tio et al., 2011, PLoS ONE 6(11): e26879 Asymmetric cell division and notch signaling specify dopaminergic neurons in Drosophila. [FBrf0216651] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Wang et al., 2011, Dev. Cell 21(3): 520--533 An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. [FBrf0215580] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...