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Gene Dmel\bb

General Information
Symbol	Dmel\bb	Species	D. melanogaster
Name	bobbed	Annotation symbol
Feature type	rRNA_gene	FlyBase ID	FBgn0000164
Created / Updated	2006-05-31/2006-05-31
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene bobbed is referred to in FlyBase by the symbol bb (FBgn0000164). It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 113 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; abdominal tergite; male genitalia; abdomen; abdominal segment; ovary; egg chamber. It has no annotated transcripts.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	bb: bobbed (K.D. Tartof and R.S. Hawley) an extreme bobbed Edith M. Wallace, unpublished. Three phenotypes are associated with bobbed mutants: thinning and shortening of bristles, etching of the abdomen, and, in extreme cases, lethality. Of these phenotypes, bristle size and lethality are the most reliable. These phenotypes are somewhat variable from fly to fly and the bristle abnormality may be obscured by such mutations as f, sn, and ty to name a few. bb/0 males, and bb/In(1)sc4Lsc8R females have phenotypes similar to, but more extreme than, that of homozygous females. bb/Y males are wild type, owing to presence of a normal allele of bb in YS; bb/bb/Y females are similarly normal in phenotype. Viability is variable. Ritossa, Atwood, and Spiegelman (1966) showed that bb contains about half as many ribosomal RNA genes (rDNA) as bb+. They conclude that the bb locus is the site of ribosomal RNA synthesis and interpreted bb mutations as partial deletions of the locus. They postulated that in bb flies the rate of protein synthesis is limited by the amount of ribosomal RNA, and the bb phenotype results in part because normal bristle production requires maximum protein synthesis on the part of the trichogen cells during a particular interval in development. The rate of rRNA synthesis is reduced in bb (Mohan and Ritossa, 1970, Dev. Biol. 22: 495-512; Mohan, 1975, Genetics 81: 723-38; Shermoen and Kiefer, 1975, Cell 4: 275-80)
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location h26-h32   Left limit from inclusion within Dp(1;3)in61j2 (FBrf0020397) Right limit from complementation mapping against In(1)sc4Lsc8R (FBrf0013319)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 20F-20F (determined by in situ hybridisation)   (Tautz et al., 1988) 20F-20F (determined by in situ hybridisation)   (Long et al., 1981) 20F-20F (determined by in situ hybridisation)   (Roiha and Glover, 1981) 20F-20F (determined by in situ hybridisation)   (Mandal and Dawid, 1981)
Experimentally Determined Recombination Data
Location	1- (Bhattacharya et al., 1999, Nurminsky, 1995.6.14) 1-66.0 (Bridges and Brehme, 1944, Neel, 1942, Goldschmidt, 1944)
Left of (cM)
Right of (cM)	f (Bhattacharya et al., 1999)
Notes	Genetic distance between bb and f calculated to be 9.3cM. (Cline, 2001)
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)	3.945, 1.995, 0.123, 0.03 (sequence analysis) (Tautz et al., 1988) 8.0 (unknown) (White and Hogness, 1977) 8.0, 3.7, 1.93, 1.85, 1.64 (northern blot) (Long and Dawid, 1979)
Comments	The primary and secondary structure of 28S rRNA expansion segments has been compared. (Linares et al., 1991)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF083522   AF191293   AF191294   AF191295   AI124285   AJ011702   AJ011703   AJ011704   J01116   J01117   J01123   J01124   K00467   K01281   K01286   K01287   K01526   K01527   K01528   K01529   K01530   K01531   K01532   K01533   K01574   K01575   K01576   K01577   K01578   K01579   K01580   K01581   K01582   K01583   K01584   K01585   K01586   K01587   K03137   K03138   K03139   K03140   K03141   M26817   M30873   S75831   V00236   X01493   X01548   X02210   X02211   X03501   X03502   X03503   X03504   X51922   X78946   X97143   Z31756   Z31795   Z31941   Z32130   Z32170   Z32171   Z32197   Z32373   Z32374   Z50228   Z50229   Z70892
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000164
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable bb11 bb1 bb28l bb2 bb3 bb41 bb4 bb6 bb7 bb8 bbOf-2 bbOf bbP2 bbT6 bbds bbfirst bbfourth bbsecond lethal bb2r bbl lethal | recessive bb20 bb21 bb22 bbD bbG2 bbG5 bbR68 bbl2 bbl lethal | male | recessive bbflex-1 bbflex-2 bbflex-3 lethal | female (with In(1)bbDf) bbds lethal | female | recessive bbflex-1 bbflex-2 bbflex-3 bbflex-4 Other Phenotypes Allele wild-type bb2m bbG1 bbt13.2 visible bb41c13 bb41e19 visible (with bb1) bb20 visible (with bb20) bb1 visible | recessive bb11 bb1 bb21 bb22 bb28l bb2 bb3 bb41 bb4 bb6 bb7 bb8 bbG3 bbG4 bbN bbOf-2 bbOf bbP2 bbT6 bbds bbfirst bbfourth bbsecond visible | dominant bbD visible | conditional ts bbP5 Sterility Allele female fertile | poor bbD Phenotype manifest in Allele macrochaeta (with bb20) bb1 abdominal tergite (with bb20) bb1 macrochaeta bb1 bb11 bb2 bb21 bb22 bb28l bb3 bb4 bb41 bb41c13 bb41e19 bb6 bb7 bb8 bbD bbG1 bbG2 bbG4 bbG5 bbOf bbOf-2 bbP2 bbT6 bbds bbfirst bbfourth bbl bbl2 abdominal tergite bb1 bb11 bb2 bb21 bb22 bb28l bb3 bb4 bb41 bb6 bb7 bb8 bbD bbG1 bbG2 bbG5 bbOf bbOf-2 bbP2 bbT6 bbfirst bbfourth bbl bbl2 bbsecond macrochaeta (with bb1) bb20 abdominal tergite (with bb1) bb20 abdominal segment bb41c13 male genitalia bbD bbamg abdomen bbG5 ovary | germ-line clone bbflex-2 egg chamber | germ-line clone bbflex-2
Classical Alleles ( 92 )
For All Classical Alleles Show
Allele of bb Class Mutagen Stocks Known lesion bb+ 1 -- bb11 spontaneous 0 -- bb1 11 -- bb20 spontaneous 0 -- bb21 spontaneous 0 -- bb22 spontaneous 0 -- bb28l spontaneous 0 -- bb2 0 Yes bb2m magnification 0 Yes bb2r reduction 0 Yes bb3 spontaneous 0 -- bb41 spontaneous 0 -- bb41c13 spontaneous 0 -- bb41e19 spontaneous 0 -- bb457 natural population 0 Yes bb481 natural population 0 Yes bb4 0 Yes bb5 0 -- bb68F 0 -- bb69d 7-bromomethyl 12 methyl benz<up>α</up> anthracine 0 -- bb6 0 Yes bb7 0 Yes bb83 0 -- bb84 0 -- bb8 0 Yes bbA56 0 Yes bbBG spontaneous detachment 0 -- bbD X ray 0 -- bbDmr238 0 Yes bbG1 spontaneous 0 -- bbG2 spontaneous 0 -- bbG2B 0 -- bbG3 spontaneous 2 -- bbG4 spontaneous 0 -- bbG5 spontaneous 0 -- bbK ethyl methanesulfonate 0 -- bbN spontaneous 2 -- bbNW 0 Yes bbOR 0 Yes bbOf-2 X ray 0 -- bbOf X ray 0 -- bbP2 ethyl methanesulfonate 0 -- bbP5 0 -- bbP5min 0 -- bbP7 ethyl methanesulfonate 0 -- bbR41 recombination 0 -- bbR43 recombination 0 -- bbR44 recombination 0 -- bbR45 recombination 0 -- bbR46 recombination 0 -- bbR47 recombination 0 -- bbR48 recombination 0 -- bbR4 recombination 0 -- bbR50 recombination 0 -- bbR53 recombination 0 -- bbR54 recombination 0 -- bbR55 recombination 0 -- bbR56 recombination 0 -- bbR5 recombination 0 -- bbR60 recombination 0 -- bbR65 recombination 0 -- bbR66 recombination 0 -- bbR68 recombination 0 -- bbR81 0 -- bbR8 recombination 0 -- bbR9 recombination 0 -- bbRex spontaneous 0 -- bbS1 0 Yes bbT6 ethyl methanesulfonate 0 -- bbUK 0 Yes bbY22 0 Yes bba 0 -- bbamg 0 -- bbb 0 -- bbc 0 -- bbds spontaneous 0 Yes bbfirst spontaneous 0 -- bbflex-1 loss of function ethyl methanesulfonate 0 -- bbflex-2 loss of function ethyl methanesulfonate 0 -- bbflex-3 loss of function γ ray 0 -- bbflex-4 loss of function γ ray 0 -- bbfourth spontaneous 0 -- bbl2 spontaneous 0 -- bbl spontaneous 6 Yes bblz144 0 -- bbn5 0 -- bbr10Δ3.1A-1 Δ2-3 0 Yes bbr10Δ3.1A-2 Δ2-3 0 Yes bbrl16 0 -- bbrl 0 Yes bbsecond spontaneous 0 -- bbsev 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bb Class Mutagen Stocks Known lesion bb144 Δ2-3 0 Yes bb144c in vitro construct | other 0 Yes bb146 in vitro construct | other 0 Yes bb199 in vitro construct | other 0 Yes bb19 in vitro construct | other 0 Yes bb201 Δ2-3 0 Yes bb202 Δ2-3 0 Yes bb210 Δ2-3 0 Yes bb211 Δ2-3 0 Yes bb42A Δ2-3 0 Yes bb49A Δ2-3 0 Yes bb608 in vitro construct | other 0 Yes bb714 in vitro construct | other 0 Yes bb7B Δ2-3 0 Yes bbHJ+B Δ2-3 0 Yes bbU+ Δ2-3 0 Yes bbr10 in vitro construct | other 0 Yes bbr10Δ3 in vitro construct | other 0 Yes bbr12 in vitro construct | other 0 Yes bbr6ΔH in vitro construct | other 0 Yes bbt13.2 in vitro construct | genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	C(1)DX   C(1)TA2   C(1;Y)7   C(1;YL)C2   DS(1)scS1Rm141R (Tolchkov et al., 2000) Df(1)15-13 (Munoz, 2003.12.10) Df(1)16-1-88 (Munoz, 2004.1.5) Df(1)16-3-129 (Munoz, 2004.1.5) Df(1)16-3-20 (Munoz, 2003.12.10) Df(1)17-87 (Schalet and Lefevre, 1973, Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)18-36 (Munoz, 2004.1.5) Df(1)19-18 (Munoz, 2003.12.10, Munoz, 2004.1.5) Df(1)19-2 (Munoz, 2004.1.5) Df(1)22 (Schalet and Lefevre, 1973) Df(1)46-1 (Zusman et al., 1985) Df(1)A19 (Lifschytz and Falk, 1968) Df(1)A209 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981, Zusman et al., 1985) Df(1)B18 (Lifschytz and Falk, 1968) Df(1)B182 (Lifschytz and Falk, 1968) Df(1)B47 (Lifschytz and Falk, 1968) Df(1)B82 (Lifschytz and Falk, 1968) Df(1)B99 (Lifschytz and Falk, 1968) Df(1)DCB1-35b (Zusman et al., 1985) Df(1)GA42 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)GA90 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981, Zusman et al., 1985, Nurminsky et al., 1994) Df(1)K5 (Rahman and Lindsley, 1981) Df(1)LB23 (Schalet and Lefevre, 1973) Df(1)R1 (Rahman and Lindsley, 1981) Df(1)R10 (Rahman and Lindsley, 1981) Df(1)R20 (Rahman and Lindsley, 1981) Df(1)R21 (Rahman and Lindsley, 1981) Df(1)R22 (Rahman and Lindsley, 1981) Df(1)R24 (Rahman and Lindsley, 1981) Df(1)R25