omb, optomotor-blind, optomotor blind, Qd, l(1)omb
transcription factor - brachyury T homolog - involved in differentiation of the brain, the CNS, the wing and in patterning of adult abdominal segments - promotes fold formation to separate wing notum and hinge territories
Please see the JBrowse view of Dmel\bi for information on other features
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Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.40
Gene model reviewed during 5.45
Gene model reviewed during 5.52
6.0, >12 (northern blot)
6, ~12, >12 (northern blot)
974 (aa)
974 (aa); 103 (kD)
Sequence comparison of a 1.1kb open reading frame
did not reveal any significant homology to other proteins in database.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bi using the Feature Mapper tool.
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
bi transcript is expressed in cardiogenic mesoderm at embryonic stage 11, but not in the embryonic/larval heart at stage 16.
The bi protein is expressed over the entire wing pouch region, as well as in the central area of the hinge region in the wing disc.
GBrowse - Visual display of RNA-Seq signals
View Dmel\bi in GBrowse 21-8
1-8
1-6.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: bi CG3578
Ectopic bi expression can lead to the growth of additional wings.
Mutant wing discs reach and even exceed the wild type size, but show extra folds. Massive apoptotic cell death occurs at the end of larval development resulting in lack of adult tissue. Loss of optic lobe tissue occurs by a similar mechanism.
bi is essential for optic lobe and wing blade development.
Mutations in the optic lobe regulatory region of the bi locus are viable and cause recognisable aberrations in the adult brain with concomitant specific defects in optomotor behaviour. Null mutations can cause highly disordered optic lobes recognisable in third instar larvae.
Flies heterozygous for bi and either T(1;2)biD2, T(1;3)biD1T or T(1;3)biD1T express the bi phenotype.
Behavioural and anatomical studies demonstrate that central brain lesions can be interpreted behaviourally.
Morgan, Nov. 1911.