• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\BicC

General Information
Symbol	Dmel\BicC	Species	D. melanogaster
Name	Bicaudal C	Annotation symbol	CG4824
Feature type	protein_coding_gene	FlyBase ID	FBgn0000182
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	Bic-C, BG:DS00913.2, br34, l(2)br34
Genomic Location
Chromosome (arm)	2L	Recombination map	2-51
Cytogenetic map	35E2-35E2	Sequence location	2L:16,042,032..16,048,626 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bicaudal C is referred to in FlyBase by the symbol Dmel\BicC (CG4824, FBgn0000182). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: mitosis; oogenesis; microtubule cytoskeleton organization; actin cytoskeleton organization; ovarian follicle cell migration. 25 alleles are reported. The phenotypes of these alleles are annotated with: follicle cell; embryonic head; egg; dorsal appendage; oocyte; pole cell; nurse cell; embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: K Homology domain; K Homology domain, type 1; Sterile alpha motif domain; Sterile alpha motif, type 1; Sterile alpha motif/pointed domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631632_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of BicC. Gene sequence location is 2L:16042032..16048626.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	BicC: Bicaudal C A maternal-effect semilethal; the majority of embryos produced by BicC/+ mothers given rise to normal larvae a minority fail to hatch and vary in phenotype. Double-abdomen embryos have a normal posterior end and the anterior end replaced by mirror image series of posterior segments, e.g. A8-A4|A4-A8 to A8-A6|A6-A8; they need not have the same number of segments on either side of the reversal of polarity, the duplicated portion having fewer segments; generally more segments seen ventrally than dorsally. Less severely affected embryros may be headless, or with reduced mouth parts, or even normal appearing but failing to hatch. The incidence and severity of abnormal embryos vary with genetic background and temperature, the incidence being highest at 25 and decreasing at lower and higher temperatures. The majority of the embryos produced by BicC/BicD trans heterozygotes are abnormal. Homozygotes are abnormal. Homozygous BicC females sterile, germ-cell differentiation blocked at the beginning of vitellogenesis. Follicle cells do not invade between oocyte and nurse cells; they do synthesize a chorion which remains open ended like a chalice or a cup; such eggs never fertilized.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35E2-35E2   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References   FBrf0091058 and FBrf0082309 differ in their conclusions about molecular mapping of the proximal breakpoint of Df(2L)Scorv18 with respect to the BicC transcription unit. Weight of evidence favours the FBrf0091058 interpretation (see Roote, 1999.1.18, personal communication).
Experimentally Determined Recombination Data
Location	2-51 (Tearle and Nusslein-Volhard, 1987, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\BicC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849) 5' UTR(s) contain an ORF that is conserved among Drosophila species; potential peptide 44 aa in length; initial methionine is conserved.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) BicC-RA FBtr0080803  NM_057517   4037   905 BicC-RB FBtr0080804  NM_165144   3697   905 BicC-RD FBtr0080805  NM_165145   3018   785
Additional Transcript Data & Comments
Reported size (kB)	4.2, 4.0, 3.5, 2.7 (northern blot) (Mahone et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein BicC-PA   FBpp0080361   97.8   905   8.93     NP_476865   AAN10927 BicC-PB   FBpp0080362   97.8   905   8.93     NP_723948   AAF53499 BicC-PD   FBpp0080363   85.0   785   9.66     NP_723949   AAN10928
Additional Polypeptide Data & Comments
Reported size (kDa)	938 (aa); 102 (kD predicted) (Mahone et al., 1995) 120 (kD observed) (Saffman et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088) Sterile alpha motif/pointed domain (IPR013761) Sterile alpha motif, type 1 (IPR021129)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141473   AA263958   AA390356   AA539428   AA540899   AA817282   AA817447   AE014134 AAF53499   AE014134 AAN10927   AE014134 AAN10928   AC092400   AE003415 AAF44981   AI517297   BF486555   BF486871   BF495379   BF496196   BF496655   BF497028   BF498965   BF499242   BF500947   BF503709   BF504034   BF505416   BI164321   BI168975   BI170344   BI171534   BI171621   BI172149   BI173315   BI215058   BI215501   BI215551   BI216100   BI216113   BI227884   BI229786   BI230045   BI234291   BI236320   BI237755   BI238043   BI239806   BI240604   BI242042   BI243243   BI243988   BI351951   BI354591   BI356302   BI363582   BI367263   BI483501   BI483670   BI487111   BI570873   BI575235   BI584159   BI584249   BI584909   BI586565   BI586672   BI587153   BI587229   BI633563   BT023837   CK604670   CK604671   CO187319   CO266185   CO271557   CO294390   CO298039   CO304746   CO315281   CO315434   CO318498   CO318883   CO321586   CO333640   CO340751   CZ473458   DN154388   DN154453   EC052112   EC054810   EC057561   EC060096   EC077769   EC079463   EC084497   EC087018   EC089731   EC210386   EC211805   EC212815   EC215188   EC235236   EC237225   EC237714   EC238926   EC239881   EC250142   EC252102   EL877504   EL877505   EV593171   EV593481   EV593647   EV594178   EV595011   EV597445   EV597874   EV598464   EV598741   EV599014   GH748624   GH749980   GH750918   GH750938   GH753159   GH754804   GH760147   GH770708   GH773684   GH777078   GH778979   GH782470   GH783109   GH785393   GH785710   GH786153   GH789144   GH790239   GH792452   GH792831   GH793305   GH794938   GH795431   GH795554   GH797030   GH798148   GH798165   GH802298   GH803509   GH803639   GH807189   GH809300   GH810500   GH810677   GH814847   GH815321   GH815323   GH816253   GH816768   GH816837   GH818306   GH818560   GH819243   GH822570   GH822806   GH823363   GH824819   GH828771   GH829168   GH829304   GH829486   GH835679   GH836045   GH837549   GH837579   GH837650   GH839477   GH839624   GH839697   GH841255   GH841531   GH842810   GH844166   GH845046   GH846538   GH848043   GH848139   GH848470   GH848536   GH849954   GH850837   GH851046   GH851808   GH852970   GH857577   GH858076   GH860559   GH862787   GH862920   GH863201   GH863804   GH864263   GH865237   GH866465   GH866702   GH870573   GH871882   GH872869   GH873797   GH877732   GH878230   GH878451   GH879439   GH879478   GH879750   GH880375   GH881921   GH887700   GH888989   GH891834   GH894263   GH898073   GH898829   GH901319   GH905625   GH907908   GH908163   GH909161   GH909301   GH912306   GH912484   GH913183   GH913468   GH914883   GH916168   GH916209   GH916243   GH916985   GH918638   GH920029   GH922908   GH923844   GH924411   GH927521   GH927753   GH929459   GH932389   GH935782   GH936072   GH937191   GH938527   GH939841   GH940102   GH940123   GH940250   GH942435   L80111   L80112   U15928 AAB51692
UniProtKB/Swiss-Prot	Q24009
UniProtKB/TrEMBL	E2QCR4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Mahone et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 9     (Mahone et al., 1995) Comment:reference states 0-4 hr AEL adult stage | female     (Mahone et al., 1995) adult stage & oogenesis   germarium region 2a & germarium region 2b & germarium region 3   (Mahone et al., 1995) adult stageoogenesis stage S1 -- S7   oocyte   (Mahone et al., 1995) adult stageoogenesis stage S8 -- S9   oocyte | anterior   (Mahone et al., 1995) adult stageoogenesis stage S10 -- S14   nurse cell   (Mahone et al., 1995)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stageoogenesis stage S3 -- S10   oocyte   (Saffman et al., 1998) adult stageoogenesis stage S10 -- S14   nurse cell   (Saffman et al., 1998)
Additional Descriptive Data
	BicC protein is first detected in the oocyte at stage 3 but remains faint until stage 5 when the levels increase substantially. In stages 4-6, BicC protein is present throughout the ooctye cytoplasm but is enriched at the posterior pole. In stages 7 to 9, it is abundant in the oocyte cytoplasm. In addition, it is enriched at the anterior of the oocyte and around the cortex. From stage 10 on, BicC protein is present at high levels in nurse cells. (Saffman et al., 1998)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary    1501.9 Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary  (1501.9) Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary  (1501.9) Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary    1501.9 Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary    1501.9 Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary  (1501.9) Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary  1501.9 Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.625 Larval Midgut    12.1 Larval Hindgut    5.2 Larval Malpighian Tubules    5.4 Larval Fat Body    40.4 Larval Salivary Gland    6.4 Larval Trachea    6.1 Larval Carcass    4.225 Adult Head    4.4 Adult Eye    9.275 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    8.2 Adult Crop    14 Adult Midgut    7.1 Adult Hindgut    5.4 Adult Malpighian Tubules    26.9 Adult Fat Body    26.9 Adult Salivary Gland    20.7 Adult Heart    6.3 Adult VirginFemale Spermatheca    30.1 Adult InseminatedFemale Spermatheca    26.3 Adult Ovary    1501.9 Adult Testis    428.1 Adult Male Accessory Gland    4.3 Adult Carcass    46.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.4   NA  Eye    9.275   NA  Brain    4   8.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8.2   NA  Crop    no informative data   no informative data  Midgut    7.1   5.2  Hindgut    5.4   5.4  Malpighian Tubules    no informative data   40.4  Fat Body    no informative data   6.4  Salivary Gland    no informative data   NA  Heart    6.3   6.1  Trachea    NA   NA  VirginFemale Spermatheca    30.1   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1501.9   NA  Testis    428.1   NA  Male Accessory Gland    4.3   4.225  Carcass    46.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female    643 ovary, mated 4-day female    428 testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female  (643) ovary, mated 4-day female  (428) testis, mated 4-day male  (73) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female  (643) ovary, mated 4-day female  (428) testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female    643 ovary, mated 4-day female    428 testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female    643 ovary, mated 4-day female    428 testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female  (643) ovary, mated 4-day female  (428) testis, mated 4-day male  (73) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female  (643) ovary, mated 4-day female  (428) testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    1 head, virgin 20-day female    0 head, mated 1-day female    4 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    5 digestive system, 4-day adult    17 digestive system, 20-day adult    11 fat body, larvae L3 wandering    0 fat body, white prepupae    5 fat body, pupae P8    3 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    25 carcass, 20-day adult    16 ovary, virgin 4-day female    643 ovary, mated 4-day female    428 testis, mated 4-day male    73 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    378 embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day    104 adult female 05day    255 adult female 30day    243 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (378) embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day  (31) adult male 30day  (33) adult female 01day  (104) adult female 05day  (255) adult female 30day  (243) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (378) embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day  104 adult female 05day  (255) adult female 30day  (243) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    378 embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day    104 adult female 05day    255 adult female 30day    243 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    378 embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day    104 adult female 05day    255 adult female 30day    243 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (378) embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day  31 adult male 30day  (33) adult female 01day  (104) adult female 05day  (255) adult female 30day  (243) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (378) embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day  104 adult female 05day  (255) adult female 30day  (243) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    378 embryo 02-04hr    11 embryo 04-06hr    3 embryo 06-08hr    2 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    1 embryo 14-16hr    2 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    0 embryo 22-24hr    1 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    7 white prepupae 24hr    10 pupae 2d postWPP    14 pupae 3d postWPP    14 pupae 4d postWPP    17 adult male 01day    24 adult male 05day    31 adult male 30day    33 adult female 01day    104 adult female 05day    255 adult female 30day    243 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    411 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    423 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    404 Caffeine 25 mg/ml 48 hrs, 4-day adult    101 Paraquat 5 mM 48 hrs, 4-day adult    291 Paraquat 10 mM 48 hrs, 4-day adult    222 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (69) cold shock, 4-day adult  (40) heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (411) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult  (53) Ethanol 2.5% 3 hrs, larvae L3  (423) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (404) Caffeine 25 mg/ml 48 hrs, 4-day adult  (101) Paraquat 5 mM 48 hrs, 4-day adult  (291) Paraquat 10 mM 48 hrs, 4-day adult  (222) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (411) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3  (423) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (404) Caffeine 25 mg/ml 48 hrs, 4-day adult  101 Paraquat 5 mM 48 hrs, 4-day adult  (291) Paraquat 10 mM 48 hrs, 4-day adult  (222) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    411 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    423 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    404 Caffeine 25 mg/ml 48 hrs, 4-day adult    101 Paraquat 5 mM 48 hrs, 4-day adult    291 Paraquat 10 mM 48 hrs, 4-day adult    222 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    411 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    423 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    404 Caffeine 25 mg/ml 48 hrs, 4-day adult    101 Paraquat 5 mM 48 hrs, 4-day adult    291 Paraquat 10 mM 48 hrs, 4-day adult    222 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (69) cold shock, 4-day adult  (40) heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (411) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult  (53) Ethanol 2.5% 3 hrs, larvae L3  (423) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (404) Caffeine 25 mg/ml 48 hrs, 4-day adult  (101) Paraquat 5 mM 48 hrs, 4-day adult  (291) Paraquat 10 mM 48 hrs, 4-day adult  (222) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  108 Cadmium 100 mM 48 hrs, 4-day adult  (411) Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult  (187) Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3  (423) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (404) Caffeine 25 mg/ml 48 hrs, 4-day adult  101 Paraquat 5 mM 48 hrs, 4-day adult  (291) Paraquat 10 mM 48 hrs, 4-day adult  (222) Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    69 cold shock, 4-day adult    40 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    411 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    187 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    53 Ethanol 2.5% 3 hrs, larvae L3    423 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    404 Caffeine 25 mg/ml 48 hrs, 4-day adult    101 Paraquat 5 mM 48 hrs, 4-day adult    291 Paraquat 10 mM 48 hrs, 4-day adult    222 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000182 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4824-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dominant | embryonic stage | maternal effect | partially BicC5 lethal | maternal effect BicC1 BicC2 BicC3 BicC4 BicC5 BicCAA4 BicCAA29 BicCAB74 BicCAB79 BicCAR72 BicCAR96 BicCAR108 BicCPE37 BicCQL53 viable, with Scer\GAL4pnr-MD237 BicCGD11439 Sterility Allele female sterile BicC4 BicCPE37 BicCPX1 BicCQL53 female sterile | dominant BicC3 female sterile | recessive BicCunspecified Phenotype manifest in Allele dorsal appendage BicC3 BicCAA4 BicCPE37 BicCQL53 dorsal appendage | maternal effect BicC4 egg BicCunspecified embryo BicCunspecified embryonic head BicC5 follicle cell BicC1 BicC3 BicC4 BicC5 BicCAB74 BicCAB79 microtubule & oocyte (with BicC3) BicC4 microtubule & oocyte (with BicC4) BicC3 nurse cell (with BicC3) BicC4 nurse cell (with BicC4) BicC3 oocyte BicCunspecified pole cell BicC5
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of BicC Class Mutagen Stocks Known lesion BicCKG10402 2 -- BicC4 ethyl methanesulfonate 1 -- BicC5 ethyl methanesulfonate 1 -- BicCd03602 P-element activity 1 -- BicCMI01569 1 -- BicC1 ethyl methanesulfonate 0 Yes BicC2 ethyl methanesulfonate 0 -- BicC3 ethyl methanesulfonate 0 Yes BicCAA29 ethyl methanesulfonate 0 -- BicCAA4 ethyl methanesulfonate 0 -- BicCAB74 ethyl methanesulfonate 0 -- BicCAB79 ethyl methanesulfonate 0 Yes BicCAR108 ethyl methanesulfonate 0 -- BicCAR72 ethyl methanesulfonate 0 -- BicCAR96 ethyl methanesulfonate 0 -- BicCd09054 0 -- BicCPE37 ethyl methanesulfonate 0 -- BicCPX1 ethyl methanesulfonate 0 -- BicCQL53 ethyl methanesulfonate 0 -- BicCTE35D-19 0 Yes BicCunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of BicC Class Mutagen Stocks Known lesion BicCGD11439 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes BicCGL00478 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BicCHMS01407 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes BicCNIG.4824R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)64j (Schupbach and Wieschaus, 1991) Df(2L)Adh-nBR126 (Roote, 1996.1.11, Roote, 1996.8) Df(2L)b88b15 (Roote, 1996.8) Df(2L)BSC278 (Christensen and Cook, 2007.5.8) Df(2L)BSC293 (Christensen and Cook, 2007.5.8) Df(2L)fn1 (Grau et al., 1984) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)osp29 (Eberl et al., 1998, Mohler and Wieschaus, 1986, Tearle and Nusslein-Volhard, 1987, Schupbach and Wieschaus, 1991, Grau et al., 1984, Roote et al., 1996, Roote, 1996.8) Df(2L)PA4 (Roote et al., 1996) Df(2L)r10 (Ashburner et al., 1990, Schupbach and Wieschaus, 1991) Df(2L)RA5 (Eberl et al., 1998, Ashburner et al., 1990, Mahone et al., 1995) Df(2L)RM5 (Roote, 1999.1.18, Ashraf et al., 1999, Ashburner et al., 1990, Mahone et al., 1995, Fambrough and Goodman, 1996) Df(2L)Sco-2 (Gubb et al., 1984) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)Scorv18 (Roote, 1999.1.18, Ashburner et al., 1990, Mahone et al., 1995, Fambrough and Goodman, 1996, Roote et al., 1996) Df(2L)Scorv23 (Grau et al., 1984) Df(2L)SS1 (Grau et al., 1984) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35BC-3 (Gubb et al., 1984, Grau et al., 1984) Df(2L)TE35BC-4 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) Df(2L)TE35D-13 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990, Mahone et al., 1995, Fambrough and Goodman, 1996, Roote, 1996.8) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) In(2L)75c (Grau et al., 1984) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Eberl et al., 1998, Ashburner et al., 1990) In(2L)TE35B-13 (Gubb et al., 1985) In(2L)TE35B-210LC163.41R (Roote et al., 1996, Gubb et al., 1997) Tp(2;2)A446 (Schupbach and Wieschaus, 1991)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A48 (Gamberi, 2010.7.23) Df(2L)A72 (Ashburner et al., 1990) Df(2L)A267 (Ashburner et al., 1990) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn2 (Grau et al., 1984) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)PZ05271-mr15 (Roote, 2000.6.13) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)RN2 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)Scorv10 (Grau et al., 1984) Df(2L)Scorv16 (Grau et al., 1984) Df(2L)Scorv19 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)Scorv25 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-10 (Mahone et al., 1995) Df(2L)TE35D-14 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-22 (Ashburner et al., 1990) In(2L)75c (Mohler and Wieschaus, 1986, Tearle and Nusslein-Volhard, 1987) In(2L)dppd36 (Mahone et al., 1995) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990, Grau et al., 1984)
Duplicated in	Dp(2;1)Scorv23 (Grau et al., 1984) Dp(2;3)osp3 (Ashburner et al., 1990) Dp(2;Y)b88b15 (Roote, 1996.8) In(2L)C163.41LC158R (Ashburner et al., 1990, Roote et al., 1996) In(2L)C163.41LTE35B-210R (Roote et al., 1996)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11439} NA P{NIG.4824R} NA P{TRiP.GL00478} NA P{TRiP.HMS01407} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}BicCd03602 NA P{XP}BicCd09054 NA miscellaneous insertions Mi{MIC}BicCMI01569 NA P{GMroX1}35E NA P{SUPor-P}BicCKG10402 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with orb (Castagnetti and Ephrussi, 2003)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Snee and Macdonald, 2009) microtubule cytoskeleton organization inferred from mutant phenotype (Snee and Macdonald, 2009) mitosis inferred from mutant phenotype (Ducat et al., 2008) oogenesis inferred from mutant phenotype (Schupbach and Wieschaus, 1991) ovarian follicle cell migration inferred from mutant phenotype (Schupbach and Wieschaus, 1991)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Lasko, 1994.10.13, van Eeden and St. Johnston, 1999, Swiss-Prot Project Members, 1991.11.1) traceable author statement (Mahowald, 2001) RNA binding inferred from electronic annotation with InterPro:IPR004087, InterPro:IPR004088, InterPro:IPR018111 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
negative regulation of oskar mRNA translation traceable author statement (Johnstone and Lasko, 2001, Leatherman and Jongens, 2003, van Eeden and St. Johnston, 1999) oogenesis non-traceable author statement (Lasko, 1994.10.13) traceable author statement (Deng and Lin, 2001)
Cellular Component
CV term Evidence References
integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1991.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions BicC allele Gene References BicCunspecified bwk (Tran and Berg, 2003) unspecified bic
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60958 DroID - A comprehensive database of gene and protein interactions. • FBgn0000182 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34946
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6640XC Dipteran inclusive ortholog search EOG6BG944 Insect inclusive ortholog search EOG69KDKH Arthropod inclusive ortholog search EOG6K6DK5 Metazoa inclusive ortholog search EOG6GXTF5
Orthologs in Drosophila Species (EOG6640XC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\BicC     Drosophila simulans   Dsim\GD24037 Y   Drosophila sechellia   Dsec\GM18651 Y   Drosophila erecta   Dere\GG25188 Y   Drosophila yakuba   Dyak\GE21299 Y   Drosophila ananassae   Dana\GF14935 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18459 Y   Drosophila persimilis   Dper\GL15307 Y   Drosophila willistoni   Dwil\GK24769 Y   Drosophila virilis   Dvir\GJ18051 Y   Drosophila mojavensis   Dmoj\GI17371 Y   Drosophila grimshawi   Dgri\GH10394 Y
Orthologs in non-Drosophila Dipterans (EOG6BG944)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010153   Anopheles gambiae Malaria mosquito  Agam\AGAP009268   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005456
Orthologs in non-Dipteran Insects (EOG69KDKH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\BicC   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003691   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19356   Atta cephalotes Leafcutter ant  Acep\ACEP12497   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14115   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22748   Linepithema humile Argentine ant  Lhum\LH15757   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18580   Solenopsis invicta Red fire ant  Sinv\SINV15479   Solenopsis invicta Red fire ant  Sinv\SINV15531   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008811   Bombyx mori Silkmoth  Bmor\BGIBMGA007342   Pediculus humanus Human body louse  Phum\PHUM202090   Tribolium castaneum Red flour beetle  Tcas\TC005315
Orthologs in non-Insect Arthropods (EOG6K6DK5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ccdc91   Daphnia pulex Water flea  Dpux\JGI_V11_336202   Daphnia pulex Water flea  Dpux\ND2   Daphnia pulex Water flea  Dpux\matK   Daphnia pulex Water flea  Dpux\JGI_V11_312371   Ixodes scapularis Deer tick  Isca\ISCW022025
Orthologs in non-Arthropod Metazoa (EOG6GXTF5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\bcc-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017139gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018221gn   Danio rerio Zebrafish  Drer\bicc2   Danio rerio Zebrafish  Drer\bicc2   Danio rerio Zebrafish  Drer\ENSDARG00000061682   Danio rerio Zebrafish  Drer\bicc1b   Xenopus tropicalis Western clawed frog  Xtro\bicc1   Gallus gallus Domestic chicken  Ggal\BICC1   Mus musculus House mouse  Mmus\Bicc1   Rattus norvegicus Norway rat  Rnor\Bicc1   Homo sapiens Human  Hsap\BICC1
Human Orthologs (1)
Gene OMIM HGNC Hsap\BICC1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24037 Drosophila sechellia Dsec\GM18651 Drosophila erecta Dere\GG25188 Drosophila yakuba Dyak\GE21299 Drosophila ananassae Dana\GF14935 Drosophila pseudoobscura pseudoobscura Dpse\GA18459 Drosophila persimilis Dper\GL15307 Drosophila willistoni Dwil\GK24769 Drosophila virilis Dvir\GJ18051 Drosophila mojavensis Dmoj\GI17371 Drosophila grimshawi Dgri\GH10394
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	30473 BicC5/CyO 34213 y1 w*; Mi{MIC}BicCMI01569 3248 BicC4 cn1 exu1 bw1/CyO 34997 y1 sc* v1; P{TRiP.HMS01407}attP2 35631 y1 sc* v1; P{TRiP.GL00478}attP40 15261 y1; P{SUPor-P}BicCKG10402/CyO; ry506
Harvard	- P{XP}BicCd03602
Kyoto	111698 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}BicCKG10402 P{neoFRT}40A/CyO y+
VDRC	v42004 w1118; P{GD11439}v42004 v42003 w1118; P{GD11439}v42003/TM3
Genomic Clones ( 2 )
	BACR12D02 BACR39L06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 244 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17549
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04215 AT04886 AT05310 AT07638 AT09935 AT10543 AT11076 AT13455 AT13762 AT16106 AT20884 AT21422 GH28002 GM16975 GM27535 LD07303 LD08973 LD20765 LD22511 LD22888 RE03975 RE09915 RE11752 RE13336 RE13435 RE14419 RE16213 RE21256 RE22017 RE22081 RE23016 RE23032 RE25267 RE27641 RE27968 RE29973 RE32360 RE34043 RE34412 RE36393 RE37483 RE39258 RE40822 RE41819 RE42415 RE48449 RE52983 RE66409 RE66589 RE70622 RH05659 RH23137 RH23285 RH24232 RH26630 RH26756 RH27631 RH27739 RH29767 SD27681
Other clones	35178 35750 61164 65813 77151 78444 107546 122840 157151 158741 167462 167468 174003 214287.24 281945 283579 CK01.32D.B12 CK01.169B.E6 Dmel_neb_002823_0942_2852 Dmel_neb_007090_0902_3530 Dmel_neb_008436_0633_3021 Dmel_neb_010824_0699_2255 Dmel_neb_011968_0630_1809 Dmel_neb_012327_0638_2165 Dmel_neb_012609_0834_2085 Dmel_neb_013305_0826_0641 Dmel_neb_014819_0686_3199 Dmel_neb_015729_0865_1489 EC052112 EC054810 EK028138 EK103851 EK145239 EK171203 EK185958 EK206820 EK233434 EK246032 EK260931 EK261444 EK272452 EK272460 EK274745 EK307525 EP11258 IP07468 RP003012449 RP003020053 RP003022796 RP003028429 RP003038699 RP003038723 RP003043165 RP003078745 RP003090885 RP003096097 RP003099383 RP003099621 RP003100818 RP003106125 RP003106419 RP003122299 RP003131838 RP003139691 RP003140057 RP003141935 RP003151032 RP003151943 RP003153999 RP003154970 RP003166281 RP003169415 RP003170100 RP003170106 RP003174071 RP003176488 RP003177084 RP003178671 RP003183723 RP003186625 RP003188181 RP003190973 RP003198929 RP003199041 RP003203853 RP003207647 RP003209570 RP003209753 RP003213837 RP003214477 RP003215701 RP003219807 RP003234015 RP003241227 RP003244815 RP003246971 RP003251992 RP003252445 RP003255690 RP003260213 RP003261325 RP003266091 RP003274183 RP003276517 RP003282855 RP003291660 RP003294477 RP003297879 RP003314158 RP003316196 RP003331006 RP003338856 RP003338993 RP003340389 RP003342898 RP003346263 RP003346995 RP003353027 RP003353927 RP003354385 RP003372396 RP003380645 RP003388485 RP003399551 RP003400801 RP003402403 RP003403394 RP003403464 RP003403949 RP003404012 RP003406185 RP003407182 RP003411174 RP003438718 RP003452750 RP003455063 RP003458041 RP003468256 RP003475676 RP003475996 RP003479113 RP003480351 RP003485736 RP003512944 RP003513819 RP003515228 RP003518723 RP003522151 RP003530682 RP003534491 RP003535285 RP003542809 RP003543464 RP003547155 RP003548970 RP003559676 RP003561067 RP003562646 RP003563332 RP003567837 RP003573058 RP003578219 RP003590950 RP003591210 RP003591473 RP003592062 RP003595282 RP003605132 RP003616266 RP003628662 RP003629870 RP003633561 RP003637160 RP003639145 RP003645700 RP003656483 RP003658994 RP003660262 RP003669451 RP003670489 RP003675092 RP003680896 UT01364
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000182 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34946
Antibody Information
	polyclonal (Saffman et al., 1998)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BicC CG4824 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	BicC produces a localised RNA, which encodes a putative RNA binding protein containing KH domains. The spatial and temporal characteristics of BicC expression and the nature of the BicC protein indicate a function for it in the localisation of specific RNAs during oogenesis. (Mahone et al., 1995) BicC is required for the correct targeting of the migrating anterior follicle cells and for specifying anterior position. (Saffman et al., 1995) Mutations at the BicC locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991) 10 additional alleles are discussed but are not named. (Ashburner et al., 1990) A maternal-effect semi-lethal; the majority of embryos produced by BicC/+ mothers given rise to normal larvae a minority fail to hatch and vary in phenotype. Double-abdomen embryos have a normal posterior end and the anterior end replaced by mirror image series of posterior segments, e.g. A8-A4|A4-A8 to A8-A6|A6-A8; they need not have the same number of segments on either side of the reversal of polarity, the duplicated portion having fewer segments; generally more segments seen ventrally than dorsally. Less severely affected embryos may be headless, or with reduced mouth parts, or even normal appearing but failing to hatch. The incidence and severity of abnormal embryos vary with genetic background and temperature, the incidence being highest at 25oC and decreasing at lower and higher temperatures. The majority of the embryos produced by BicC/BicD trans heterozygotes are abnormal. Homozygotes are abnormal. Homozygous BicC females sterile, germ-cell differentiation blocked at the beginning of vitellogenesis. Follicle cells do not invade between oocyte and nurse cells; they do synthesize a chorion which remains open ended like a chalice or a cup; such eggs never fertilized.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057517 NM_165144 NM_165145 RefSeq (Proteins) • NP_476865 NP_723948 NP_723949 DDBJ / EMBL / GenBank • AA141473 AA263958 AA390356 AA539428 AA540899 AA817282 AA817447 AAB51692 AAF44981 AAF53499 AAN10927 AAN10928 AC092400 AE003415 CZ473458 L80111 L80112 U15928 Entrez Gene - A searchable database of RefSeq genes. • 34946 UniProtKB/Swiss-Prot • Q24009 UniProtKB/TrEMBL • E2QCR4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sterile alpha motif domain (IPR001660) K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088) Sterile alpha motif/pointed domain (IPR013761) Sterile alpha motif, type 1 (IPR021129)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60958 DroID - A comprehensive database of gene and protein interactions. • FBgn0000182 DRSC - Results from RNAi screens. • FBgn0000182 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000182 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4824-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000182 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34946 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/bicaudalc.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34946 modMine - Data generated by the modENCODE project. • FBgn0000182
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BG:DS00913.2 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) Bic-C (Cui et al., 2008, Paliouras and Lasko, 2004, Styhler et al., 2002, Mahowald, 2001, Paliouras and Lasko, 2002, Kloc et al., 2002, Bolshakov et al., 2002, Johnstone and Lasko, 2001, Chicoine and Lasko, 2001, Powers et al., 2001, Paliouras and Lasko, 2001, Lipshitz and Smibert, 2000, Paliouras et al., 2000, Saffman et al., 1998, Grams and Korge, 1998, Styhler et al., 1998, Mahone et al., 1997, Hijal et al., 1997, Rother et al., 1997, Nakamura et al., 1996, Fambrough and Goodman, 1996, Micklem, 1995, Saffman and Lasko, 1995, Saffman and Lasko, 1996, Mahone et al., 1995, Saffman et al., 1995, Lasko, 1995, St. Johnston, 1993, Gamberi et al., 2006, Gamberi and Lasko, 2007, Gamberi and Lasko, 2008, Tadros et al., 2007, Chicoine et al., 2007, Kugler et al., 2009, Gamberi, 2010.7.23) BicC (Christensen and Cook, 2007.5.8, Christensen and Cook, 2007.5.8, Sofola et al., 2007, McDermott et al., 2012, Gan et al., 2010, Hartmann et al., 2011, Benoit et al., 2008, Font-Burgada et al., 2008, Leemans et al., 2001, Thomsen et al., 2010, Japanese National Institute of Genetics, 2012.5.21) BICC (Sofola et al., 2007) br34 (Grau et al., 1984, Gubb et al., 1985) CG4824 (Ducat et al., 2008, Hayden and Bosco, 2008, Ni et al., 2011.7.19) Dromel_CG4824_FBtr0080804_bicc_mORF (Hayden and Bosco, 2008) l(2)br34 (Ashburner et al., 1990, Gubb et al., 1984)
Name Synonym	Bicaudal-C (Cui et al., 2008, Berg, 2005, Leatherman and Jongens, 2003, Tran and Berg, 2001, Tran and Berg, 2001, Lasko, 1994.10.13, Gamberi and Lasko, 2008, Chicoine et al., 2007, Kugler et al., 2009, Gouw et al., 2009) Bicaudal C (Ducat et al., 2008, Hayden and Bosco, 2008, Snee and Macdonald, 2009, Leemans et al., 2001)
Secondary FlyBase IDs
References ( 114 )
Generate a list of	All references relating to this gene ( 114 )
List References by type	Research paper  ( 43 ) Supplementary material  ( 6 ) Review  ( 16 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 21 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	McDermott et al., 2012, Biol. Open 1(5): 488--497 Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. [FBrf0218722] Hartmann et al., 2011, RNA 17(3): 453--468 Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. [FBrf0212988] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...