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Gene Dmel\Brd

General Information
Symbol	Dmel\Brd	Species	D. melanogaster
Name	Bearded	Annotation symbol	CG3096
Feature type	protein_coding_gene	FlyBase ID	FBgn0000216
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map	3-42
Cytogenetic map	71A4-71A4	Sequence location	3L:14,965,767..14,966,298 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Bearded is referred to in FlyBase by the symbol Dmel\Brd (CG3096, FBgn0000216). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: Notch signaling pathway; sensory organ development; cell fate specification. 36 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; sensillum; external compound sense organ; adult segment; adult mesothoracic segment; peripheral nervous system; compound cell cluster organ; nervous system; sensillum trichodeum; dorsocentral bristle; wing margin bristle; mesothoracic preepisternum. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1636672_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Brd. Gene sequence location is 3L:14965767..14966298.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Brd: Bearded (M. Leviten) Causes production of supernumerary chaetae and sensilla at or near normal positions. Brd1 homozygotes survive and exhibit more severe phenotypes than heterozygotes. Brd1/+ = Brd1/Df(3L)Brd. Brd alleles affect all classes of adult sensory organs. Brd1 strongly affects macrochaetae and other imaginal-disc sensilla (i.e., trichoid, campaniform, basiconic), but only mildly increases microchaete density. Brd3 and other alleles produce more severe microchaete phenotypes, in both disc and histoblast derived tissues, as well as exhibiting the Brd1 phenotypes. In addition to sensillum multiplication, Brd1 homozygotes also exhibit bristle loss, with anterior orbitals absent (>90%) and a less frequent loss of ocellar macrochaetae (<5%). This bristle loss occurs in other Brd genotypes and is most severe for Brd3 homozygotes. The combination of sensilla multiplication and loss phenotypes is made more severe by loss-of-function mutations at Notch and neuralized, and are decreased in the presence of three wild type copies of these genes. The ethyl-methanesulfonate-induced point revertants of Brd1 tested (Brdrv1-4) are homozygous viable, viable in trans to Brd deficiencies, and display no mutant phenotypes in either situation.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71A4-71A4   Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Tom maps 2kb from Brd.   (Zaffran, 1999.3.3)
Experimentally Determined Recombination Data
Location	3-42
Left of (cM)	th
Right of (cM)	Gl
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Brd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Brd-RA FBtr0075621  NM_057541   532   81
Additional Transcript Data & Comments
Reported size (kB)	0.6 (northern blot) (Leviten et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Brd-PA   FBpp0075374   9.2   81   8.72     NP_476889   AAF49693
Additional Polypeptide Data & Comments
Reported size (kDa)	81 (aa); 9 (kD) (Leviten et al., 1997)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49693   AF016542 AAC47751   AY863975 AAW64291   AY863976 AAW64292   AY863977 AAW64293   AY863978 AAW64294   AY863979 AAW64295   AY863980 AAW64296   AY863981 AAW64297   AY863982 AAW64298   AY863983 AAW64299   AY863984 AAW64300   AY863985 AAW64301   AY863986 AAW64302   AY863987 AAW64303   AY863988 AAW64304   AY863989 AAW64305   AY863990 AAW64306   AY863991 AAW64307   AY863992 AAW64308   AY863993 AAW64309   AY863994 AAW64310   AY863995 AAW64311   AY863996 AAW64312   AY863997 AAW64313   AY863998 AAW64314   BT100176   CO189000   CO195146   CO300182   CO303846   CO319959   CO344130   CZ483628   EC076343   EC085613   EC217538   EC217546   EC218188   EC236878   EC250467   EC252543   GH944380   GH946040   GH947458   GH948204   GH948549   GH951386   GH951396   GH951469   GH954309   GH955017   GH955822   GH957280   GH958402   GH958935   GH960787   GH963275   GH966048   GH966391   GH967803   GH967915   GH969817   GH970185   GH973040   GH975575   GH976175   GH976445   GH977023   GH978212   GH981422   GH981594   GH984300   GH984481   GH984526
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O16528 Q5G1Y7 Q5G1W4 Q5G1X9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159970 3L:14,965,676..14,965,681 bound_moiety=ac-XP comment=bound by da/da, da/ac, da/sc proneural protein complexes comment=Brd_E1_E_box evidence=experimental (Singson et al., 1994) regulatory region FBsf0000435168 3L:14,964,895..14,965,426 evidence=Reporter construct (in vivo) (Powell et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000161311 3L:14,966,128..14,966,136 comment=Brd box 1 evidence=predicted (Leviten et al., 1997) regulatory region FBsf0000161312 3L:14,966,175..14,966,183 comment=Brd box 2 evidence=predicted (Leviten et al., 1997) regulatory region FBsf0000161313 3L:14,966,233..14,966,241 comment=Brd box 3 evidence=predicted (Leviten et al., 1997) regulatory region FBsf0000161314 3L:14,966,247..14,966,253 comment=GY box evidence=predicted (Leviten et al., 1997) regulatory region FBsf0000435561 3L:14,965,629..14,965,805 evidence=Reporter construct (in vivo) (Singson et al., 1994, Halfon, 2012.6.19) regulatory region FBsf0000436211 3L:14,964,319..14,965,805 evidence=Reporter construct (in vivo) (Singson et al., 1994, Halfon, 2012.6.19) regulatory region FBsf0000436413 3L:14,964,304..14,965,631 evidence=Reporter construct (in vivo) (Powell et al., 2004, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   morphogenetic furrow | vicinity of   (Lai et al., 2000) morphogenetic furrow   (Lai et al., 2000) eye disc   (Lai et al., 2000) prepupal stage P4   sensillum campaniformium of wing   (Lai et al., 2000) Comment:8 hr APF northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 12     (Leviten et al., 1997) Comment:reference states 4-8 hr AEL third instar larval stage   external sensory organ precursor cell   (Leviten et al., 1997) proneural cluster   (Leviten et al., 1997) proneural cluster of imaginal disc   (Leviten et al., 1997) imaginal disc   (Leviten et al., 1997)
Additional Descriptive Data
	Brd transcripts are detected in third instar larval eye discs in the morphogenetic furrow in closely spaced stripes, one anterior to the stripe of dpp staining in the furrow and one within the furrow and posterior to it. They are detected in the pupal wing at 8h APF in large clusters of proximal campaniform sensilla. (Lai et al., 2000) Brd transcripts are detected weakly in preblastoderm embryos, are abundant in 4-8hr embryos and drop off dramatically in later embryonic stages on northern blots. Brd is expressed specifically in proneural clusters in the imaginal discs. In the wing imaginal disc, it is present at the positions of all developing adult external sensory organs. Further, it was found that Brd expression precedes sensory organ precursor specification. (Leviten et al., 1997)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    204.875 Larval Midgut    15.2 Larval Hindgut    11.3 Larval Malpighian Tubules    5.9 Larval Fat Body    10.5 Larval Salivary Gland    9.7 Larval Trachea    12.675 Larval Carcass    57.175 Adult Head    8.1 Adult Eye    5.925 Adult Brain    4 Adult Thoracic-Abdominal Ganglion    11.1 Adult Crop    15.2 Adult Midgut    12.1 Adult Hindgut    11.9 Adult Malpighian Tubules    5.5 Adult Fat Body    14 Adult Salivary Gland    29.8 Adult Heart    2.95 Adult VirginFemale Spermatheca    12.3 Adult InseminatedFemale Spermatheca    11 Adult Ovary    4.6 Adult Testis    1.6 Adult Male Accessory Gland    15.6 Adult Carcass    10.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    8.1   NA  Eye    5.925   NA  Brain    4   204.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   5.9  Malpighian Tubules    5.5   no informative data  Fat Body    no informative data   9.7  Salivary Gland    no informative data   NA  Heart    2.95   12.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4.6   NA  Testis    1.6   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (58) central nervous system, larvae L3  (90) central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering  (81) carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (58) central nervous system, larvae L3  (90) central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering  (81) carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    90 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    1 fat body, white prepupae    23 fat body, pupae P8    8 carcass, larvae L3 wandering    81 carcass, 1-day adult    0 carcass, 4-day adult    2 carcass, 20-day adult    2 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    132 embryo 04-06hr    439 embryo 06-08hr    457 embryo 08-10hr    247 embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr  (132) embryo 04-06hr  (439) embryo 06-08hr  (457) embryo 08-10hr  (247) embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr  26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr  (132) embryo 04-06hr  (439) embryo 06-08hr  (457) embryo 08-10hr  (247) embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    132 embryo 04-06hr    439 embryo 06-08hr    457 embryo 08-10hr    247 embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    132 embryo 04-06hr    439 embryo 06-08hr    457 embryo 08-10hr    247 embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr  (132) embryo 04-06hr  (439) embryo 06-08hr  (457) embryo 08-10hr  (247) embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr  26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr  132 embryo 04-06hr  (439) embryo 06-08hr  (457) embryo 08-10hr  (247) embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    132 embryo 04-06hr    439 embryo 06-08hr    457 embryo 08-10hr    247 embryo 10-12hr    15 embryo 12-14hr    7 embryo 14-16hr    3 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    1 embryo 22-24hr    3 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    14 white prepupae new    13 white prepupae 12hr    26 white prepupae 24hr    6 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3  (28) Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3  (34) Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3  28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3  (34) Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    12 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    17 Cadmium 50 mM 12 hrs, larvae L3    28 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    34 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000216 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3096-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive Brd2 lethal | recessive Brd6 BrdPI1 Brdrv5 Brdrv6 viable Brd1 Brd3rv1 Brd4 Brd5 BrdCB02665 BrdP1 BrdPI2 BrdPI3 BrdPrv1 BrdPrv2 BrdPrv3 Brdrv1 Brdrv2 Brdrv3 Brdrv4 Sterility Allele female fertile Brd1 male fertile Brd1 Other Phenotypes Allele visible Brd2 Brd2rv1 Brd3rv2 Brd4 Brd5 Brd6 Brdmut123+GYmut BrdP1 BrdPI1 BrdPI2 BrdPI3 visible, with Scer\GAL469B BrdScer\UAS.cLa visible, with Scer\GAL4Bx-MS1096 BrdScer\UAS.cLa visible, with Scer\GAL4ey.PS BrdScer\UAS.cLa visible, with Scer\GAL4GMR.PF BrdScer\UAS.cLa visible, with Scer\GAL4sca-537.4 BrdScer\UAS.cLa visible | dominant Brd1 visible | heat sensitive Brdhs.PLa visible | recessive Brd3 wild-type BrdPrv1 BrdPrv2 BrdPrv3 Brdrv1 Brdrv2 Brdrv3 Brdrv4 Brdrv5 Brdrv6 Phenotype manifest in Allele anterior dorsocentral bristle Brdmut123+GYmut anterior sternopleural bristle Brdmut123+GYmut eye Brd2 Brd3 eye, with Scer\GAL4ey.PS BrdScer\UAS.cLa eye, with Scer\GAL4GMR.PF BrdScer\UAS.cLa eye photoreceptor cell, with Scer\GAL4GMR.PF BrdScer\UAS.cLa head bristle Brdmut123+GYmut head bristle, with Scer\GAL4sca-537.4 BrdScer\UAS.cLa interommatidial bristle, with Scer\GAL4GMR.PF BrdScer\UAS.cLa lens, with Scer\GAL4ey.PS BrdScer\UAS.cLa macrochaeta Brd1 Brd2 Brd2rv1 Brd3 Brd3rv2 Brd4 Brd5 Brd6 BrdP1 BrdPI1 BrdPI2 BrdPI3 Brdmut123+GYmut macrochaeta | ectopic Brd1 Brd3 macrochaeta | heat sensitive Brdhs.PLa microchaeta Brd1 Brd3 microchaeta, with Scer\GAL4sca-537.4 BrdScer\UAS.cLa microchaeta | heat sensitive Brdhs.PLa ocellar bristle Brdmut123+GYmut ommatidium, with Scer\GAL4ey.PS BrdScer\UAS.cLa ommatidium, with Scer\GAL4GMR.PF BrdScer\UAS.cLa scutellar bristle, with Scer\GAL4sca-537.4 BrdScer\UAS.cLa scutum & microchaeta, with Scer\GAL4sca-537.4 BrdScer\UAS.cLa sensillum basiconicum Brd1 sensillum campaniformium Brd1 sensillum trichodeum Brd1 wing margin bristle, with Scer\GAL469B BrdScer\UAS.cLa wing margin bristle, with Scer\GAL4Bx-MS1096 BrdScer\UAS.cLa wing sensillum & wing vein, with Scer\GAL469B BrdScer\UAS.cLa wing sensillum & wing vein, with Scer\GAL4Bx-MS1096 BrdScer\UAS.cLa
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of Brd Class Mutagen Stocks Known lesion Brd1 hypermorphic allele - genetic evidence spontaneous 1 Yes Brdf01143 piggyBac transposase 1 -- Brd2 gamma ray 0 -- Brd2rv1 ethyl methanesulfonate 0 -- Brd3 hypermorphic allele - genetic evidence P-element activity gamma ray 0 -- Brd3rv1 ethyl methanesulfonate 0 -- Brd3rv2 ethyl methanesulfonate 0 -- Brd4 gamma ray 0 -- Brd5 gamma ray 0 -- Brd6 gamma ray 0 -- BrdCB02665 P-element activity 0 Yes BrdF716.1 Delta2-3 0 Yes BrdP1 P-element activity 0 Yes BrdPI1 Delta2-3 0 -- BrdPI2 Delta2-3 0 -- BrdPI3 Delta2-3 0 -- BrdPrv1 Delta2-3 0 Yes BrdPrv2 Delta2-3 0 -- BrdPrv3 Delta2-3 0 -- Brdrv1 ethyl methanesulfonate 0 Yes Brdrv2 ethyl methanesulfonate 0 Yes Brdrv3 ethyl methanesulfonate 0 Yes Brdrv4 ethyl methanesulfonate 0 Yes Brdrv5 ethyl methanesulfonate 0 -- Brdrv6 ethyl methanesulfonate 0 -- Brdunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Brd Class Mutagen Stocks Known lesion BrdKK111053 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Brd3xBrd+GYmut.arm.T:Avic\GFP-YFP in vitro construct - site directed mutagenesis 0 Yes Brdarm.T:Avic\GFP-YFP in vitro construct - regulatory fusion 0 Yes BrdGD13572 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes BrdGYmut.arm.T:Avic\GFP-YFP in vitro construct - site directed mutagenesis 0 Yes Brdhs.PLa in vitro construct - regulatory fusion 0 Yes Brdhs.PLb in vitro construct - regulatory fusion 0 Yes Brdmut123+GYmut gain of function allele in vitro construct - site directed mutagenesis 0 Yes BrdScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes BrdtLa in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Brd12 (Leviten and Posakony, 1996) Df(3L)Brd15 (Galewsky and Schulz, 1992) Df(3L)Brd-C1 (Chanet et al., 2009) Df(3L)Exel6125 (Ryder, 2004.4.26) Df(3L)Exel6126 (Ryder, 2004.4.26) In(3)Brd4 (Leviten and Posakony, 1996) In(3)Brd5 (Leviten and Posakony, 1996) In(3)Brd6 (Leviten and Posakony, 1996) In(3L)Brd2 (Leviten and Posakony, 1996) In(3L)Brd3 (Leviten and Posakony, 1996)
Duplicated in	Dp(3;2)Brd-C (Chanet et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13572} NA P{KK111053} NA P{UAS-Brd.L} NA reporter construct P{Brd0.19-lacZ} No P{Brd0.19M-lacZ} No P{Brd1.5-lacZ} No P{Brd1.5M-lacZ} No heat-shock construct P{hs-Brd.La} NA P{hs-Brd.Lb} NA characterization construct P{arm-YFP.Brd3'UTR.3xBrd+GYmut} NA P{arm-YFP.Brd3'UTR.GYmut} NA P{arm-YFP.Brd3'UTR} NA P{Brdmut123+GYmut} NA P{BrdtLa} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions blood{}Brd1 NA P{}Brd3 NA P{}BrdP1 NA P{GT1}BG01768 NA P{GT1}BG02319 NA P{PTT-GB}BrdCB02665 NA PBac{WH}Brdf01143 NA insertion of mobile activating element P{Mae-UAS.6.11}BrdF716.1 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell fate specification inferred from mutant phenotype (Lai et al., 2000) Notch signaling pathway inferred from mutant phenotype (Lai et al., 2000) sensory organ development inferred from mutant phenotype (Lai et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
sensory organ precursor cell fate determination traceable author statement (Lai et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Brd allele Gene References Brd1 amos (Lai, 2003) Dl (Leviten and Posakony, 1996) Dns (Leviten and Posakony, 1996) E(Brd)M10 (Leviten and Posakony, 1996) H (Bang et al., 1991) N (Leviten and Posakony, 1996) neur (Leviten and Posakony, 1996) Brd3 Dl (Leviten and Posakony, 1996) N (Leviten and Posakony, 1996) neur (Leviten and Posakony, 1996) Brdunspecified H (Bang et al., 1991) unspecified E(Brd)M10 (Tanda et al., 1996) neur (Klein and Campos-Ortega, 1992) os (Mukherjee et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64945 DroID - A comprehensive database of gene and protein interactions. • FBgn0000216 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39620
Orthologs
OrthoDB Orthologs (8) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GXG7M Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6GXG7M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Brd     Drosophila simulans   Dsim\GD14511 Y   Drosophila sechellia   Dsec\GM25491 Y   Drosophila erecta   Dere\GG15704 Y   Drosophila yakuba   Dyak\GE22036 Y   Drosophila ananassae   Dana\GF24625 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15923 Y   Drosophila persimilis   Dper\GL24653 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (7) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14511 Drosophila sechellia Dsec\GM25491 Drosophila erecta Dere\GG15704 Drosophila yakuba Dyak\GE22036 Drosophila ananassae Dana\GF24625 Drosophila pseudoobscura pseudoobscura Dpse\GA15923 Drosophila persimilis Dper\GL24653
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	4042 Brd1 pp
Harvard	- PBac{WH}Brdf01143
VDRC	v107929 P{KK111053}VIE-260B
Genomic Clones ( 1 )
	BACR01H12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	RT02933
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	57394 103315 176958 214353.53 CK01.13C.E12 CK01.13D.D12 CK01.52D.G7 EC39768 EK042728 EK177541 EK242940 EK281556 EP18722 RP004018479 RP004034506 RP004062863 RP004090123 RP004104389 RP004116613 RP004160693 RP004165506 RP004165600 RP004197304 RP004197633 RP004198584 RP004199203 RP004199653 RP004209396 RP004225290 RP004230336 RP004231450 RP004241467 RP004262788 RP004304104 RP004319027 RP004325586 RP004339730 RP004387694 RP004430725 RP004436072 RP004461759 RP004463131 RP004480262 RP004484207 RP004517329 RP004543256
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000216 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39620
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Brd CG3096 (Bayraktaroglu, 1999.11)
Source for database merge of
Additional comments	Possibly "Hi" was a "Brd" allele.
Other Comments
	Overexpression of Brd antagonises the N pathway in multiple cell fate decisions during adult sensory organ development. (Lai et al., 2000) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) The Brd 3' UTR confers negative regulatory activity on heterologous reporter genes in vivo. (Lai and Posakony, 1997) Gain of function Brd mutations cause multiplication of adult sensory organs. Loss of function mutations of H and the AS-C are epistatic to Brd. (Leviten and Posakony, 1996) Electrophoretic mobility shift assays demonstrate that Brd is directly activated in proneural clusters of the late third-instar wing imaginal disc by protein complexes that include the ac and sc bHLH proteins. (Singson et al., 1994) Mutations of Brd cause either sensory organ multiplication or loss. Cell markers reveal that multiplication results from the determination of supernumerary precursor cells and loss from the inappropriate differentiation of all precursor cells as neurons. (Levitan and Posakony, 1991) Causes production of supernumerary chaetae and sensilla at or near normal positions. Brd alleles affect all classes of adult sensory organs. The combination of sensilla multiplication and loss phenotypes is made more severe by loss-of-function mutations at N and neur and are decreased in the presence of three wild-type copies of these genes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057541 RefSeq (Proteins) • NP_476889 DDBJ / EMBL / GenBank • AAC47751 AAF49693 AAW64291 AAW64292 AAW64293 AAW64294 AAW64295 AAW64296 AAW64297 AAW64298 AAW64299 AAW64300 AAW64301 AAW64302 AAW64303 AAW64304 AAW64305 AAW64306 AAW64307 AAW64308 AAW64309 AAW64310 AAW64311 AAW64312 AAW64313 AAW64314 AF016542 AY863975 AY863976 AY863977 AY863978 AY863979 AY863980 AY863981 AY863982 AY863983 AY863984 AY863985 AY863986 AY863987 AY863988 AY863989 AY863990 AY863991 AY863992 AY863993 AY863994 AY863995 AY863996 AY863997 AY863998 CZ483628 U13067 Entrez Gene - A searchable database of RefSeq genes. • 39620 UniProtKB/TrEMBL • O16528 Q5G1W4 Q5G1X9 Q5G1Y7
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 64945 DroID - A comprehensive database of gene and protein interactions. • FBgn0000216 DRSC - Results from RNAi screens. • FBgn0000216 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000216 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3096-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000216 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39620 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/beardd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39620 modMine - Data generated by the modENCODE project. • FBgn0000216 REDfly - A database of transcriptional regulatory elements. • FBgn0000216
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Brd (Reeves and Posakony, 2005, Mukherjee et al., 2006, Reiter et al., 2007, Bardin and Schweisguth, 2006, Buszczak et al., 2007, Macdonald and Long, 2005, Powell et al., 2004, Southall and Brand, 2009, Firth and Baker, 2007, Carrera et al., 2008, Fontana and Posakony, 2009, Chanet et al., 2009, Lee et al., 2009, Magalhaes et al., 2007, Egger et al., 2010, Powell et al., 2008, Rand et al., 2008, Rebeiz et al., 2012) brd (De Renzis et al., 2006, Firth and Baker, 2007) Brd-C (Miller and Posakony, 2008) CG3096 (Carrera et al., 2008, Keleman et al., 2009.8.5) DmelCG3096 (Duncan and Dearden, 2010)
Name Synonym	Bearded (Arbouzova and Zeidler, 2006, Fontana and Posakony, 2008, Miller and Posakony, 2008, Powell et al., 2004, Chanet et al., 2009, Lee et al., 2009) bearded (Zhou et al., 2008, Firth and Baker, 2007)
Secondary FlyBase IDs
References ( 79 )
Generate a list of	All references relating to this gene ( 79 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 2 ) Review  ( 11 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 11 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Book  ( 1 ) Letter  ( 1 )
Recent research papers ( 2 )
	Chanet and Schweisguth, 2012, Nat. Cell Biol. 14(5): 467--476 Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila. [FBrf0218201] Rebeiz et al., 2012, Dev. Biol. 362(2): 282--294 Ancestral and conserved cis-regulatory architectures in developmental control genes. [FBrf0217764] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...