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Gene Dmel\bsk

General Information
Symbol	Dmel\bsk	Species	D. melanogaster
Name	basket	Annotation symbol	CG5680
Feature type	protein_coding_gene	FlyBase ID	FBgn0000229
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	JNK, DJNK, D-JNK
Genomic Location
Chromosome (arm)	2L	Recombination map	2-33
Cytogenetic map	31B1-31B1	Sequence location	2L:10,247,502..10,250,501 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene basket is referred to in FlyBase by the symbol Dmel\bsk (CG5680, FBgn0000229). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; JUN kinase activity. There is experimental evidence for 27 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; cellular process involved in reproduction; biological regulation; immune response; response to chemical stimulus; defense response; multicellular organismal reproductive process; post-embryonic organ morphogenesis; growth. 49 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; external compound sense organ; nervous system; adult segment; dorsal thoracic disc; protein complex; synapse; epithelial furrow; axon; late extended germ band embryo. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Mitogen-activated protein (MAP) kinase, JNK; Mitogen-activated protein (MAP) kinase, conserved site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. Gene sequence location is 2L:10247502..10250501.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	bsk: basket Homozygous lethal; embryos have large dorsal anterior hole.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31B1-31B1     (Riesgo-Escovar, 1996.10.3) 31B-31C   (determined by in situ hybridisation)   (Sluss et al., 1996) 31B-31B   (determined by in situ hybridisation)   (Riesgo-Escovar et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Riesgo-Escovar, 1996.10.3) 2-33 (Tearle and Nusslein-Volhard, 1987, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bsk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bsk-RB FBtr0080087  NM_164900   1535   372 bsk-RE FBtr0300982  NM_001169461   1564   372 bsk-RF FBtr0302378  NM_001169459   1797   372
Additional Transcript Data & Comments
Reported size (kB)	1.85, 1.8 (northern blot) (Sluss et al., 1996) 1.5 (northern blot) (Riesgo-Escovar et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bsk-PB   FBpp0079676   43.0   372   6.39     NP_723541   AAF52883 bsk-PE   FBpp0290204   43.0   372   6.39     NP_001162932   ACZ94221 bsk-PF   FBpp0291573   43.0   372   6.39     NP_001162930   ACZ94220
Additional Polypeptide Data & Comments
Reported size (kDa)	372 (aa) (Sluss et al., 1996) 353 (aa); 49 (kD observed); 49 (kD predicted) (Riesgo-Escovar et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Mitogen-activated protein (MAP) kinase, conserved site (IPR003527) Serine/threonine-protein kinase, active site (IPR008271) Mitogen-activated protein (MAP) kinase, JNK (IPR008351) Protein kinase-like domain (IPR011009)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697511   AE014134 AAF52883   AE014134 ACZ94220   AE014134 ACZ94221   AI109623   AI259734   AY070865 AAL48487   AY122221 AAM52733   BI168174   BI169763   BI171668   BI212564   BI239448   BI243273   BI362187   BI364154   BI365741   BI374322   BI375387   BI375391   BI634861   BP551355   BP551356   BT001548 AAN71303   CL705896   CO190579   CO193544   CO286658   CO303465   CO310493   CO327167   CO329989   CO344017   CO344385   CZ480636   EC051012   EC051997   EC054018   EC055010   EC063130   EC064687   EC227861   EC229537   EC229945   EC237667   EC241377   EC253851   EC259888   EV580712   EV582287   GH808739   GH848142   GH880838   GH881558   GH898821   U49180 AAB97094   U49249 AAB48381   U50965 AAB51187   U50966 AAB51188   U73196 AAC47325   Z50635
UniProtKB/Swiss-Prot	P92208
UniProtKB/TrEMBL	E1JHD6 E2QCS5 Q8IGX1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000436306 2L:10,250,419..10,251,479 evidence=Reporter construct (in vitro) (Yoshioka et al., 2012, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   organism | ubiquitous   (Riesgo-Escovar et al., 1996) embryonic stage 6 -- 7   posterior transverse furrow   (Riesgo-Escovar et al., 1996) cephalic furrow   (Riesgo-Escovar et al., 1996) anterior transverse furrow   (Riesgo-Escovar et al., 1996) embryonic stage 8 -- 17   presumptive embryonic/larval central nervous system   (Riesgo-Escovar et al., 1996) presumptive embryonic/larval peripheral nervous system   (Riesgo-Escovar et al., 1996) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic antennal sense organ   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) third instar larval stage   eye disc   (Sluss et al., 1996) imaginal disc   (Riesgo-Escovar et al., 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic epidermis   (Sluss et al., 1996) embryonic brain   (Sluss et al., 1996) presumptive embryonic/larval central nervous system   (Sluss et al., 1996) presumptive embryonic/larval peripheral nervous system   (Sluss et al., 1996) embryonic stage | early     (Sluss et al., 1996) embryonic stage & larval stage & pupal stage     (Sluss et al., 1996) third instar larval stage   wing disc   (Sluss et al., 1996) imaginal disc   (Sluss et al., 1996) adult stage | female     (Sluss et al., 1996) adult stage | male     (Sluss et al., 1996)   fat body   (Sluss et al., 1996) hemocyte   (Sluss et al., 1996)
Additional Descriptive Data
	bsk is expressed ubiquitously at low levels in early embryos. During gastrulation, high levels of bsk mRNA are expressed in cells involved in morphogenetic movements; the cephalic furrow, the anterior and posterior transverse folds, and the leading edge of the ventrolateral epidermis. Begininning in stages 8-9, expression is observed in the CNS and PNS. Expression persists in the CNS through larval stages. Expression is also observed in imaginal discs. (Riesgo-Escovar et al., 1996) bsk transcripts are present at a low level in early cleavage stage embryos. During germ band extension, bsk transcripts are present in all germ layers. During germ band retraction, intense staining is seen in the epidermis and in the CNS. At stage 14, staining is increased in the CNS and is present in the lateral epidermis extending up to the amnioserosa. At stage 15, strong staining is observed in the CNS, the brain, and some peripheral neurons. Strong staining persists in the fully retracted CNS at stage 16. bsk expression is also observed in third instar larval imaginal discs. High levels of bsk transcripts are seen in the eye and wing imaginal discs. On northern blots, bsk transcripts are observed at all stages of development as well as in fat body and in a hemocyte cell line. (Sluss et al., 1996) The 1.85kb bsk transcript is detected in early embryos. (Sluss et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
axon inferred from direct assay (Rallis et al., 2010) dendrite inferred from direct assay (Rallis et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  (33) central nervous system, pupae P8  (55) head, virgin 1-day female  (29) head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male  (40) head, mated 4-day male  (41) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3  (33) central nervous system, pupae P8  (55) head, virgin 1-day female  29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male  (40) head, mated 4-day male  (41) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    33 central nervous system, pupae P8    55 head, virgin 1-day female    29 head, virgin 4-day female    25 head, virgin 20-day female    18 head, mated 1-day female    20 head, mated 4-day female    22 head, mated 20-day female    13 head, mated 1-day male    40 head, mated 4-day male    41 head, mated 20-day male    43 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    13 fat body, larvae L3 wandering    4 fat body, white prepupae    9 fat body, pupae P8    8 carcass, larvae L3 wandering    16 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    7 ovary, virgin 4-day female    3 ovary, mated 4-day female    3 testis, mated 4-day male    5 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr  (41) embryo 06-08hr  (56) embryo 08-10hr  (53) embryo 10-12hr  (54) embryo 12-14hr  (62) embryo 14-16hr    25 embryo 16-18hr  (34) embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  (29) white prepupae new  (27) white prepupae 12hr  (27) white prepupae 24hr  (33) pupae 2d postWPP  (32) pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr  (41) embryo 06-08hr  (56) embryo 08-10hr  (53) embryo 10-12hr  (54) embryo 12-14hr  (62) embryo 14-16hr    25 embryo 16-18hr  (34) embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  29 white prepupae new  27 white prepupae 12hr  27 white prepupae 24hr  (33) pupae 2d postWPP  32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8 embryo 02-04hr    11 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    53 embryo 10-12hr    54 embryo 12-14hr    62 embryo 14-16hr    25 embryo 16-18hr    34 embryo 18-20hr    19 embryo 20-22hr    13 embryo 22-24hr    20 larva L1    17 larva L2    20 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    29 white prepupae new    27 white prepupae 12hr    27 white prepupae 24hr    33 pupae 2d postWPP    32 pupae 3d postWPP    22 pupae 4d postWPP    10 adult male 01day    16 adult male 05day    14 adult male 30day    13 adult female 01day    8 adult female 05day    9 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (35) embryonic 1182-4H    22 embryonic GM2  (42) embryonic Kc167  (35) embryonic S1  (45) embryonic S3  (45) leg disc CME L1  (29) wing disc CME-W2  (41) wing disc ML-DmD8  (30) wing disc ML-DmD9  (27) wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (45) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (63) tumorous blood cells mbn2  (42) ovary fGS/OSS    15 ovary OSC  26 ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (35) embryonic 1182-4H    22 embryonic GM2  (42) embryonic Kc167  (35) embryonic S1  (45) embryonic S3  (45) leg disc CME L1  29 wing disc CME-W2  (41) wing disc ML-DmD8  30 wing disc ML-DmD9  27 wing disc ML-DmD16-c3  (39) wing disc ML-DmD21  (45) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11  (34) antennal disc ML-DmD20-c5  (36) mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2  (63) tumorous blood cells mbn2  (42) ovary fGS/OSS    15 ovary OSC  26 ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    35 embryonic 1182-4H    22 embryonic GM2    42 embryonic Kc167    35 embryonic S1    45 embryonic S3    45 leg disc CME L1    29 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    45 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    34 antennal disc ML-DmD20-c5    36 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    63 tumorous blood cells mbn2    42 ovary fGS/OSS    15 ovary OSC    26 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    7 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    9 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    8 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • HL02677 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5680-RB;CG5680-RC;CG5680-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for bsk Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL469B bskDN.Scer\UAS lethal, with Scer\GAL4e22c bskDN.Scer\UAS lethal | embryonic stage bsk1 bsk2 bskflp147E bskJ27 lethal | embryonic stage | recessive bsk1 bsk2 bskunspecified viable bskEY01915 viable, with Scer\GAL4pnr-MD237 bskGD10555 Sterility Allele fertile bskEY01915 Other Phenotypes Allele chemical resistant, with Scer\GAL4arm.PS bskScer\UAS.cBa chemical sensitive | dominant bsk2 long lived | RU486 conditional, with Scer\GAL4bun-GSG5961 bskGD10555 bskK53R.Scer\UAS neuroanatomy defective, with Scer\GAL4ato.3.6 bskDN.Scer\UAS neuroanatomy defective, with Scer\GAL4elav-C155 bskK53R.Scer\UAS neuroanatomy defective, with Scer\GAL4ey-OK107 bskDN.Scer\UAS bskGD10555 neuroanatomy defective, with Scer\GAL4GMR.PF bskDN.Scer\UAS neuroanatomy defective | conditional, with Scer\GAL4tey-5053A bskK53R.Scer\UAS neuroanatomy defective | pupal stage | somatic clone bskflp147E neuroanatomy defective | somatic clone bsk2 bskH15 neuroanatomy defective | somatic clone | third instar larval stage bskH15 neurophysiology defective, with Scer\GAL4elav-C155 bskK53R.Scer\UAS planar polarity defective, with Scer\GAL4hs.2sev bskK53R.Scer\UAS bskScer\UAS.cBa planar polarity defective, with Scer\GAL4pnr-MD237 bskGD10555 short lived | heat sensitive, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B bskGD10555 stress response defective, with Scer\GAL4da.G32 bskGD10555 stress response defective, with Scer\GAL4Ilp2.PR bskGD10555 bskK53R.Scer\UAS stress response defective | RU486 conditional, with Scer\GAL4Ilp2.Switch.PK bskGD10555 bskK53R.Scer\UAS visible, with Scer\GAL4GMR.PF bskDN.Scer\UAS visible, with Scer\GAL4opa bskDN.Scer\UAS visible, with Scer\GAL4pnr-MD237 bskGD10555 wild-type bsk+t5 bsk+t10 wound healing defective, with Scer\GAL4A58 bskDN.Scer\UAS wound healing defective, with Scer\GAL4en-e16E bskDN.Scer\UAS Phenotype manifest in Allele adult gut | heat sensitive, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B bskGD10555 adult gut | RU486 conditional, with Scer\GAL4bun-GSG5961 bskK53R.Scer\UAS bskGD10555 adult thorax, with Scer\GAL4ap-md544 bskK53R.Scer\UAS adult thorax, with Scer\GAL4opa bskDN.Scer\UAS amnioserosa (with bsk1) bsk2 amnioserosa (with bsk2) bsk1 axon, with Scer\GAL4ey-OK107 bskDN.Scer\UAS bskGD10555 axon & dorsal cluster neuron, with Scer\GAL4ato.3.6 bskDN.Scer\UAS axon & dorsal cluster neuron | somatic clone bsk2 axon | pupal stage | somatic clone bskflp147E axon | somatic clone bskH15 bouton, with Scer\GAL4elav-C155 bskK53R.Scer\UAS dorsal closure embryo bsk1 dorsal closure embryo | germline clone bsk1 embryo | dorsal, with Scer\GAL469B bskDN.Scer\UAS embryo | dorsal, with Scer\GAL4e22c bskDN.Scer\UAS embryo | dorsal closure stage bskflp147E embryonic/first instar larval cuticle bsk2 embryonic/first instar larval cuticle | anterior | dorsal bskunspecified embryonic/first instar larval cuticle | dorsal bsk1 bsk2 bskJ27 bskflp147E embryonic/first instar larval cuticle | dorsal, with Scer\GAL4arm.PS bskK53R.Scer\UAS embryonic/first instar larval cuticle | dorsal | germline clone bsk1 embryonic/larval fat body | somatic clone, with Scer\GAL4Act.PU bskScer\UAS.cBa embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4Act5C.PU bskdsRNA.Scer\UAS embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4lz-gal4 bskdsRNA.Scer\UAS embryonic abdominal segment | dorsal, with Scer\GAL4ptc-559.1 bskDN.Scer\UAS embryonic dorsal epidermis bsk1 embryonic dorsal epidermis (with bsk1) bsk2 embryonic dorsal epidermis (with bsk2) bsk1 embryonic dorsal epidermis (with Df(2L)flp147E) bsk1 embryonic epidermis | dorsal bsk1 bsk2 bskflp147E embryonic leading edge cell, with Scer\GAL4arm.PS bskK53R.Scer\UAS embryonic leading edge cell, with Scer\GAL4ptc-559.1 bskDN.Scer\UAS eye, with Scer\GAL4ey.PH bskScer\UAS.cBa eye, with Scer\GAL4GMR.PF bskDN.Scer\UAS eye, with Scer\GAL4hs.2sev bskK53R.Scer\UAS bskScer\UAS.cBa eye, with Scer\GAL4αTub84B.PL bskK53R.Scer\UAS eye photoreceptor cell, with Scer\GAL4GMR.PF bskDN.Scer\UAS filamentous actin (with bsk1) bsk2 filamentous actin (with bsk2) bsk1 intestinal stem cell | heat sensitive, with Scer\GAL4esg-NP5130, Scer\GAL80ts.αTub84B bskGD10555 Kenyon cell, with Scer\GAL4ey-OK107 bskDN.Scer\UAS bskGD10555 Kenyon cell | pupal stage | somatic clone bskflp147E Kenyon cell | somatic clone bskH15 lamina, with Scer\GAL4GMR.PF bskDN.Scer\UAS male genitalia, with Scer\GAL4en.PU bskDN.Scer\UAS mesothoracic cleft | ectopic, with Scer\GAL4ap-md544 bskK53R.Scer\UAS mesothoracic tergum, with Scer\GAL4pnr-MD237 bskGD10555 neuromuscular junction | larval stage, with Scer\GAL4elav-C155 bskK53R.Scer\UAS neuron, with Scer\GAL4GMR.PF bskDN.Scer\UAS ommatidium, with Scer\GAL4hs.2sev bskK53R.Scer\UAS bskScer\UAS.cBa ommatidium | somatic clone bskflp147E peripodial epithelium, with Scer\GAL4opa bskDN.Scer\UAS peripodial epithelium, with Scer\GAL4Ubx-lac1-Gal4 bskScer\UAS.cBa photoreceptor cell | somatic clone bskflp147E segmental nerve | conditional, with Scer\GAL4tey-5053A bskK53R.Scer\UAS stage 13 embryo (with bsk1) bsk2 stage 13 embryo (with bsk2) bsk1 stage 14 embryo (with bsk1) bsk2 stage 14 embryo (with bsk2) bsk1 stage 15 embryo (with bsk1) bsk2 stage 15 embryo (with bsk2) bsk1 synapse, with Scer\GAL4elav-C155 bskK53R.Scer\UAS thorax, with Scer\GAL4ap-md544 bskDN.Scer\UAS thorax, with Scer\GAL4pnr-MD237 bskdsRNA.Scer\UAS tract | pupal stage | somatic clone bskflp147E ventral furrow, with Scer\GAL4twi.PG bskScer\UAS.cBa wing disc, with Scer\GAL4Bx-MS1096-KE bskK53R.Scer\UAS wing disc, with Scer\GAL4en-e16E bskDN.Scer\UAS
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of bsk Class Mutagen Stocks Known lesion bsk1 ethyl methanesulfonate 2 Yes bsk2 ethyl methanesulfonate 2 Yes bske02863 piggyBac transposase 1 -- bskEY01915 P-element activity 1 -- bskJ27 hypomorphic allele - genetic evidence 1 -- bskflp147E amorphic allele - genetic evidence P-element activity 0 Yes bsk3 ethyl methanesulfonate 0 -- bskc04167 0 -- bskG179 ethyl methanesulfonate 0 Yes bskG258 ethyl methanesulfonate 0 Yes bskG290 ethyl methanesulfonate 0 Yes bskG368 ethyl methanesulfonate 0 Yes bskG400 ethyl methanesulfonate 0 Yes bskG418 ethyl methanesulfonate 0 Yes bskG536 ethyl methanesulfonate 0 Yes bskG577 ethyl methanesulfonate 0 Yes bskG688 ethyl methanesulfonate 0 Yes bskG760 ethyl methanesulfonate 0 Yes bskH15 ethyl methanesulfonate 0 Yes bskunspecified 0 --
Alleles Carried on Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bsk Class Mutagen Stocks Known lesion bskDN.Scer\UAS in vitro construct - regulatory fusion 2 Yes bskGD10555 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bskScer\UAS.cAYa in vitro construct - regulatory fusion 2 Yes bskGL00431 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskGL00603 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskHMS00777 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskJF01274 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskJF01275 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskK53R.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes bskKK108156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bskScer\UAS.cBa in vitro construct - regulatory fusion 1 Yes bsk+t10 in vitro construct - genomic fragment 0 Yes bsk+t5 in vitro construct - genomic fragment 0 Yes bskAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 -- bskAct5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bskAct5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bskdsRNA.cCa in vitro construct - RNAi 0 Yes bskdsRNA.cIa in vitro construct - RNAi 0 Yes bskdsRNA.cPa in vitro construct - RNAi 0 Yes bskdsRNA.cSa in vitro construct - RNAi 0 Yes bskdsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes bskHMS01579 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes bskhs.PS in vitro construct - regulatory fusion 0 Yes bskmTPY.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes bskNIG.5680R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes bskScer\UAS.cNa in vitro construct - regulatory fusion 0 Yes bskScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes bskT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes bskVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC143 (Christensen and Cook, 2006.3.8) Df(2L)BSC144 (Christensen and Cook, 2006.3.8) Df(2L)BSC206 (Christensen and Cook, 2006.8.30) Df(2L)Exel6026 (Ryder, 2004.4.26) Df(2L)flp147E (Zecchini et al., 1999, Bohni et al., 1999, Goberdhan et al., 1999, Shen and Dahmann, 2005, Sluss et al., 1996, Riesgo-Escovar and Hafen, 1997) Df(2L)flp170B (Paricio et al., 1999, Sluss et al., 1996) Df(2L)G2 (Clegg et al., 1993) Df(2L)J1 (Clegg et al., 1993) Df(2L)J2 (Clegg et al., 1993) Df(2L)J3 (Clegg et al., 1993) Df(2L)J16 (Clegg et al., 1993) Df(2L)J17 (Clegg et al., 1993) Df(2L)J27 (Tearle and Nusslein-Volhard, 1987, Clegg et al., 1993, Riesgo-Escovar et al., 1996) Df(2L)J39 (Clegg et al., 1993) Df(2L)J77 (Clegg et al., 1993) Df(2L)J106 (Clegg et al., 1993) Df(2L)prd2.27
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10555} NA P{KK108156} NA P{TRiP.GL00431} NA P{TRiP.GL00603} NA P{TRiP.HMS00777} NA P{TRiP.HMS01579} NA P{TRiP.JF01274} NA P{TRiP.JF01275} NA P{UAS-bsk.A-Y} NA P{UAS-bsk.B} NA P{UAS-bsk.DN} NA P{UAS-bsk.IR} NA P{UAS-bsk.K53R} NA P{UAS-bsk.mTPY} NA P{UAS-bsk.myc} NA P{UAS-bsk.N} NA heat-shock construct P{DJNK} NA characterization construct P{NIG.5680R} NA P{VDRC.bsk.U} NA P{WAX} NA P{WX} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}bskEY01915 NA miscellaneous insertions P{SUPor-P}KG00043 NA PBac{PB}bskc04167 NA PBac{RB}bske02863 NA
Gene Ontology: Function, Process & Cellular Component ( 40 unique terms )
Terms Based on Experimental Evidence ( 31 terms )
Molecular Function
CV term Evidence References
JUN kinase activity inferred from direct assay AND inferred from sequence or structural similarity with human MAPK9 (Riesgo-Escovar et al., 1996) inferred from direct assay AND inferred from sequence or structural similarity with human MAPK10 AND inferred from sequence or structural similarity with human MAPK8 (assigned by UniProtKB) (Sluss et al., 1996) inferred from mutant phenotype (Botella et al., 2001) protein binding inferred from physical interaction with Cka (Chen et al., 2002)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Sluss et al., 1996) axon extension inferred from mutant phenotype (Srahna et al., 2006) axon guidance inferred from mutant phenotype (Berger et al., 2008) border follicle cell migration inferred from genetic interaction with Pvr (Mathieu et al., 2007) cellular response to arsenic-containing substance inferred from direct assay (Ryabinina et al., 2006) cellular response to cadmium ion inferred from direct assay (Ryabinina et al., 2006) cellular response to reactive oxygen species inferred from direct assay (Ryabinina et al., 2006) collateral sprouting of injured axon inferred from mutant phenotype (Xiong et al., 2010) determination of digestive tract left/right asymmetry inferred from genetic interaction with puc (Taniguchi et al., 2007) dorsal appendage formation inferred from mutant phenotype (Suzanne et al., 2001) dorsal closure inferred from mutant phenotype (assigned by UniProtKB) (Sluss et al., 1996) embryonic anterior midgut (ectodermal) morphogenesis inferred from genetic interaction with puc (Taniguchi et al., 2007) embryonic morphogenesis inferred from direct assay (assigned by UniProtKB) (Riesgo-Escovar and Hafen, 1997) imaginal disc-derived male genitalia morphogenesis inferred from mutant phenotype (Kuranaga et al., 2011) imaginal disc fusion, thorax closure inferred from mutant phenotype (Cha et al., 2003) JNK cascade inferred from direct assay AND inferred from sequence or structural similarity with human MAPK8 (assigned by UniProtKB) (Sluss et al., 1996) JUN phosphorylation inferred from mutant phenotype (Botella et al., 2001) melanization defense response inferred from mutant phenotype (Bidla et al., 2007) micropyle formation inferred from mutant phenotype (Suzanne et al., 2001) negative regulation of JUN kinase activity inferred from mutant phenotype (Uhlirova et al., 2005) neuron development inferred from mutant phenotype (Rallis et al., 2010) neuron projection morphogenesis inferred from mutant phenotype (Rallis et al., 2010) ovarian follicle cell development inferred from mutant phenotype (Jordan et al., 2006) response to heat inferred from mutant phenotype (Karpac et al., 2009) response to oxidative stress inferred from mutant phenotype (Karpac et al., 2009) wound healing inferred from direct assay (Manfruelli et al., 2002) inferred from direct assay (assigned by UniProtKB) (Ramet et al., 2002) inferred from mutant phenotype (Bosch et al., 2005) wound healing, spreading of epidermal cells inferred from mutant phenotype (Galko and Krasnow, 2004)
Cellular Component
CV term Evidence References
axon inferred from direct assay (Rallis et al., 2010) dendrite inferred from direct assay (Rallis et al., 2010)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR003527, InterPro:IPR008351 (FlyBase Curators et al., 2004-) JUN kinase activity inferred from sequence or structural similarity (Riesgo-Escovar et al., 1995) non-traceable author statement (Martin-Blanco, 2000) traceable author statement (Stronach and Perrimon, 2002, Noselli and Agnes, 1999) MAP kinase activity inferred from sequence or structural similarity with EMBL:L35236 (FlyBase, 1992-) protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) dorsal closure non-traceable author statement (Van Aelst and Symons, 2002, Harden, 2002) traceable author statement (Noselli and Agnes, 1999) establishment of planar polarity non-traceable author statement (Mlodzik, 2002) JNK cascade inferred from sequence or structural similarity (Riesgo-Escovar et al., 1995) traceable author statement (Noselli and Agnes, 1999, Harden, 2002) MAPK cascade non-traceable author statement (Martin-Blanco, 2000, Lemaitre, 2000.12.20) protein phosphorylation non-traceable author statement (Morrison et al., 2000) traceable author statement (Noselli and Agnes, 1999) Wnt receptor signaling pathway non-traceable author statement (Wedlich, 2002)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:P45983 (assigned by UniProtKB) (Swiss-Prot Project Members, 1997.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
bsk - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - BEAF-32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG11109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG16884 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG17768 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG3436 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG5525 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - CG8258 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - U3-55K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - pr experimental knowledge based (Guruharsha et al., 2011) bsk - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) bsk - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bsk allele Gene References bsk1 aop (Riesgo-Escovar and Hafen, 1997) by (Lee et al., 2003) Cka (Chen et al., 2002) Jra (Hou et al., 1997, Riesgo-Escovar and Hafen, 1997) kay (Riesgo-Escovar and Hafen, 1997) msn (Su et al., 1998) peb (Pickup et al., 2002) Pkn (Lu and Settleman, 1999) Rac1 (Fanto et al., 2000, Stronach and Perrimon, 2002) Rala (Sawamoto et al., 1999) Sac1 (Wei et al., 2003) bsk2 cno (Takahashi et al., 1998) dsh (Boutros et al., 1998, Paricio et al., 1999) egr (Igaki et al., 2002) msn (Su et al., 1998, Paricio et al., 1999) peb (Pickup et al., 2002) puc (Wang et al., 2003) Pvr (Ishimaru et al., 2004) Rac1 (Fanto et al., 2000) Rala (Sawamoto et al., 1999) rpr (Kuranaga et al., 2002) Src42A (Tateno et al., 2000) Tak1 (Takatsu et al., 2000, Mihaly et al., 2001) bskDN.Scer\UAS egr (Igaki et al., 2002) rpr (Kuranaga et al., 2002) bskflp147E Mad (Shen and Dahmann, 2005) msn (Su et al., 1998) Rala (Sawamoto et al., 1999) tkv (Shen and Dahmann, 2005) bskhs.PS cno (Takahashi et al., 1998) bskK53R.Scer\UAS Tak1 (Mihaly et al., 2001) bskScer\UAS.cBa arm (McEwen et al., 2000) by (Lee et al., 2003) cno (Boettner et al., 2003) dsh (Boutros et al., 1998) puc (Sanyal et al., 2002) unspecified Abl (Leyssen et al., 2005) Csk (Read et al., 2004) dpp (Staehling-Hampton et al., 1995) dsh (Srahna et al., 2006, Strutt et al., 1997) egr (Geuking et al., 2005) flw (Kirchner et al., 2007) fz (Strutt et al., 1997) H (Mueller et al., 2005) hep (Cha et al., 2005, Geuking et al., 2005) ics (Kadrmas et al., 2004) L (Singh et al., 2006) N (Zecchini et al., 1999) park (Cha et al., 2005) puc (McEwen and Peifer, 2005) Pvr (Mathieu et al., 2007) Rac1 (Srahna et al., 2006) Ret (Read et al., 2005) slpr (Polaski et al., 2006) Traf4 (Cha et al., 2003) trc (He et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69288 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000229 DroID - A comprehensive database of gene and protein interactions. • FBgn0000229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44801 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P92208
Orthologs
OrthoDB Orthologs (75) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG600246 Dipteran inclusive ortholog search EOG6MCX7X Insect inclusive ortholog search EOG65B0B1 Arthropod inclusive ortholog search EOG6XPNXB Metazoa inclusive ortholog search EOG68H7WT
Orthologs in Drosophila Species (EOG600246)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\bsk     Drosophila simulans   Dsim\GD22289 Y   Drosophila sechellia   Dsec\GM11912 Y   Drosophila erecta   Dere\GG23964 Y   Drosophila yakuba   Dyak\GE26274 Y   Drosophila ananassae   Dana\GF14126 Y   Drosophila persimilis   Dper\GL18977 Y   Drosophila willistoni   Dwil\GK12444 Y   Drosophila virilis   Dvir\GJ21884 Y   Drosophila mojavensis   Dmoj\GI10639 Y   Drosophila grimshawi   Dgri\GH13559 Y
Orthologs in non-Drosophila Dipterans (EOG6MCX7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008634   Anopheles gambiae Malaria mosquito  Agam\AGAP009461   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001158
Orthologs in non-Dipteran Insects (EOG65B0B1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\bsk   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003693   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19359   Atta cephalotes Leafcutter ant  Acep\ACEP12506   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14116   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22749   Linepithema humile Argentine ant  Lhum\LH15767   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18589   Solenopsis invicta Red fire ant  Sinv\SINV15506   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004372   Bombyx mori Silkmoth  Bmor\BGIBMGA007358   Pediculus humanus Human body louse  Phum\PHUM128040   Tribolium castaneum Red flour beetle  Tcas\bsk
Orthologs in non-Insect Arthropods (EOG6XPNXB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\N   Daphnia pulex Water flea  Dpux\rps4   Ixodes scapularis Deer tick  Isca\ISCW020577
Orthologs in non-Arthropod Metazoa (EOG68H7WT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\jnk-1 Y Caenorhabditis elegans Nematode  Cele\pmk-1 Y Caenorhabditis elegans Nematode  Cele\pmk-2 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010118gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028478gn Y Danio rerio Zebrafish  Drer\mapk14b Y Danio rerio Zebrafish  Drer\mapk8 Y Danio rerio Zebrafish  Drer\mapk12 Y Danio rerio Zebrafish  Drer\si:dkey-14d8.5 Y Danio rerio Zebrafish  Drer\mapk14a Y Danio rerio Zebrafish  Drer\mapk8a Y Danio rerio Zebrafish  Drer\im:7136778 Y Danio rerio Zebrafish  Drer\mapk9 Y Xenopus tropicalis Western clawed frog  Xtro\mapk11 Y Xenopus tropicalis Western clawed frog  Xtro\mapk10 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031922 Y Xenopus tropicalis Western clawed frog  Xtro\mapk8 Y Xenopus tropicalis Western clawed frog  Xtro\mapk14 Y Xenopus tropicalis Western clawed frog  Xtro\mapk12 Y Gallus gallus Domestic chicken  Ggal\MAPK8 Y Gallus gallus Domestic chicken  Ggal\MAPK14 Y Gallus gallus Domestic chicken  Ggal\MAPK13 Y Gallus gallus Domestic chicken  Ggal\MAPK9 Y Gallus gallus Domestic chicken  Ggal\MAPK12 Y Gallus gallus Domestic chicken  Ggal\MAPK10 Y Gallus gallus Domestic chicken  Ggal\MAPK11 Y Mus musculus House mouse  Mmus\Mapk14 Y Mus musculus House mouse  Mmus\Mapk12 Y Mus musculus House mouse  Mmus\Mapk8 Y Mus musculus House mouse  Mmus\Mapk10 Y Mus musculus House mouse  Mmus\Mapk11 Y Mus musculus House mouse  Mmus\Mapk13 Y Mus musculus House mouse  Mmus\Mapk9 Y Rattus norvegicus Norway rat  Rnor\Mapk9 Y Rattus norvegicus Norway rat  Rnor\Mapk11 Y Rattus norvegicus Norway rat  Rnor\Mapk14 Y Rattus norvegicus Norway rat  Rnor\Mapk13 Y Rattus norvegicus Norway rat  Rnor\Mapk10 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000020155 Y Homo sapiens Human  Hsap\MAPK9 Y Homo sapiens Human  Hsap\MAPK12 Y Homo sapiens Human  Hsap\MAPK11 Y Homo sapiens Human  Hsap\MAPK13 Y Homo sapiens Human  Hsap\ENSG00000112062 Y Homo sapiens Human  Hsap\ENSG00000109339 Y
Human Orthologs (6)
Gene OMIM HGNC Hsap\MAPK9     Hsap\MAPK12     Hsap\MAPK11     Hsap\MAPK13     Hsap\ENSG00000112062     Hsap\ENSG00000109339
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22289 Drosophila sechellia Dsec\GM11912 Drosophila erecta Dere\GG23964 Drosophila yakuba Dyak\GE26274 Drosophila ananassae Dana\GF14126 Drosophila persimilis Dper\GL18977 Drosophila willistoni Dwil\GK12444 Drosophila virilis Dvir\GJ21884 Drosophila mojavensis Dmoj\GI10639 Drosophila grimshawi Dgri\GH13559
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	9310 w*; P{UAS-bsk.B}2 6409 w1118 P{UAS-bsk.DN}2 9311 w*; P{UAS-bsk.K53R}20.1a 6407 y1 w1118; P{UAS-bsk.A-Y}1 31323 y1 v1; P{TRiP.JF01275}attP2
Harvard	- PBac{RB}bske02863
Kyoto	108773 w1118 P{UAS-bsk.DN}2 108772 y1 w1118; P{UAS-bsk.A-Y}1 107709 Df(2L)J27, bskJ27/CyO, P{sevRas1.V12}FK1
VDRC	v104569 P{KK108156}VIE-260B v34138 w1118; P{GD10555}v34138 v34139 w1118; P{GD10555}v34139/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR07H08 BACR30M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL02677 RE08746 RE11033
Other clones	DPiM_HL02677
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08863 LP03221 RE13488 RE17670 RE35933 RE40855 RE46685 RE49215 RE51115 RE61878 RE63182 RE63186 RH39112
Other clones	63420 99368 121643 191785 CK01.34D.C12 CK01.60B.D11 CK01.60C.D9 Dmel_dig_014641_0605_2287 Dmel_dig_020874_0584_2870 EC36359 EC051012 EC051997 EC054018 EC055010 EC253851 EC259888 EK048714 EK063515 EK221838 EK241623 EK294316 EP06220 EP18526 EP19201 FGM212D09 RP003066554 RP003396600 RP003428029 RP003433251 RP003652529
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44801
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: bsk CG5680 (Bayraktaroglu, 2000.4.13)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) The wg and bsk (JNK) signaling cascades collaborate to promote both dorsal closure and ventral patterning. (McEwen et al., 2000) bsk functions in the establishment of planar polarity in the eye. (Weber et al., 2000) Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues. (Paricio et al., 1999) msn acts through bsk in epithelial planar polarity (EPP) signalling. (Paricio et al., 1999) Genetic and over-expression assays show that dsh protein activates JNK cascades. (Boutros et al., 1998) Phylogenetic and functional relationships of MAPKs is studied based on 93 non-redundant full length sequences, 2 atomic structures and known functions of MAPKs. (Kultz, 1998) Leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression. (Glise and Noselli, 1997) Jra in the embryo is a downstream target of the bsk signal transduction pathway during dorsal closure formation. The function of the bsk/Jra pathway is to control the localised expression of dpp. Both in the embryo and during photoreceptor cell determination Jra is not regulated by a pathway that involved rl. (Hou et al., 1997) The bsk pathway is functionally linked to the dpp pathway, the bsk pathway controls dorsal closure at least in part by regulating dpp expression in the leading edge cells. dpp expression is reduced or absent in leading edge cells of embryos lacking bsk function. Transcription factors Jra and aop are required for dorsal closure. Results suggest that the bsk pathway governs dorsal closure at least partially by regulating dpp expression via phosphorylation of Jra and aop. (Riesgo-Escovar and Hafen, 1997) bsk function is not required for cell fate specification in the eye. (Riesgo-Escovar et al., 1996) bsk mediates an immune response in cells in culture and morphogenesis in vivo. (Sluss et al., 1996) bsk embryos display relatively subtle defects in the nervous system, late in development. Brain and gut protrude from an unusually anterior dorsal hole. (Cole et al., 1995) Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS induced alleles of bsk. (Goberdhan et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164900 NM_001169459 NM_001169461 RefSeq (Proteins) • NP_723541 NP_001162930 NP_001162932 DDBJ / EMBL / GenBank • AA697511 AAB48381 AAB51187 AAB51188 AAB97094 AAC47325 AAF52883 AAF52884 AAL48487 AAM52733 AAN71303 ACZ94220 ACZ94221 AY070865 AY122221 BI168174 BI169763 BT001548 CL705896 CZ480636 U49180 U49249 U50965 U50966 U73196 Z50635 Entrez Gene - A searchable database of RefSeq genes. • 44801 UniProtKB/Swiss-Prot • P92208 UniProtKB/TrEMBL • E1JHD6 E2QCS5 Q8IGX1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Mitogen-activated protein (MAP) kinase, conserved site (IPR003527) Serine/threonine-protein kinase, active site (IPR008271) Mitogen-activated protein (MAP) kinase, JNK (IPR008351) Protein kinase-like domain (IPR011009) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • HL02677
Linkouts
	BioGRID - A database of protein and genetic interactions • 69288 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000229 DroID - A comprehensive database of gene and protein interactions. • FBgn0000229 DRSC - Results from RNAi screens. • FBgn0000229 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5680-RB;CG5680-RC;CG5680-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000229 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 93519 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44801 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/basktjk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44801 modMine - Data generated by the modENCODE project. • FBgn0000229 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P92208
Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym	bsk (Solon et al., 2009, Bates et al., 2008, Singh et al., 2006, Mace et al., 2005, Tyler et al., 2007, Abraham et al., 2007, Walther and Pichaud, 2007, Mihaly et al., 2001, Harvey et al., 2003, Jenny et al., 2003, Pantalacci et al., 2003, Pantalacci, 2003, Janody and Treisman, 2006, McEwen and Peifer, 2005, Cha et al., 2003, Kadrmas et al., 2004, Kanao et al., 2012, Yoshioka et al., 2008, Scuderi and Letsou, 2005, Pezzulo et al., 2012, Pfleger et al., 2007, Christensen and Cook, 2006.8.30, Tiwari and Roy, 2009, Tripura et al., 2011, Tsuzuki et al., 2012, Karpac et al., 2009, Lennox and Stronach, 2010, Neuman-Silberberg, 2007, Ohayon et al., 2009, Srahna et al., 2006, Cerrato et al., 2006, He et al., 2005, Sinenko et al., 2011, Kirchner et al., 2007, Sun et al., 2010, Valanne et al., 2007, Uhlirova and Bohmann, 2006, Mace et al., 2005, Polaski et al., 2006, Mathieu et al., 2007, Sato et al., 2006, Fanto and McNeill, 2004, Muñoz-Descalzo et al., 2007, Ohsawa et al., 2011, Homsy et al., 2006, Wech and Nagel, 2005, Wada et al., 2007, Montrasio et al., 2007, Lee et al., 2007, Hwang et al., 2010, Baek et al., 2010, Massaro et al., 2009, Srivastava et al., 2007, Thomas et al., 2009, Zhao et al., 2011, Grzeschik et al., 2010, Davis et al., 2008, Bhuin and Roy, 2010, Brumby et al., 2011, Wu et al., 2010, Seisenbacher et al., 2011, Mathew et al., 2011, Caussinus et al., 2008, Xue et al., 2007, Horiuchi et al., 2007, Fiehler and Wolff, 2008, Lee et al., 2005, Llense and Martín-Blanco, 2008, Babcock et al., 2008, Bidla et al., 2007, Williams et al., 2007, Uthaman et al., 2008, Baril et al., 2009, Junion et al., 2007, Wertheim et al., 2011, Igaki et al., 2009, Bossuyt et al., 2009, Widmann and Dahmann, 2009, Chang and Neufeld, 2009, Hull-Thompson et al., 2009, Shimizu et al., 2008, Maezawa et al., 2009, Chang and Neufeld, 2009, Weake et al., 2009, Wu et al., 2009, Igaki et al., 2006, Owusu-Ansah et al., 2008, Sawamura and Yamamoto, 2004, Shen and Ganetzky, 2009, Wu et al., 2009, Grima et al., 2008, Shen et al., 2010, Rallis et al., 2010, Owusu-Ansah and Banerjee, 2009, Kim et al., 2005, Guichard et al., 2006, Leong et al., 2009, Tuxworth et al., 2009, Gettings et al., 2010, Kim et al., 2010, Franciscovich et al., 2008, Wu et al., 2009, Beam and Moberg, 2010, Djiane and Mlodzik, 2010, Neisch et al., 2010, Froldi et al., 2010, Yavari et al., 2010, Curtis et al., 2007, Bergantiños et al., 2010, Chi et al., 2010, Garlena et al., 2010, Xiong et al., 2010, Chen et al., 2010, Yoshioka et al., 2012, Maher et al., 2011, Padash-Barmchi et al., 2010, Marinho et al., 2011, Lee et al., 2009, Radyuk et al., 2010, Peralta et al., 2007, Lam et al., 2010, Kuranaga et al., 2011, Terashima and Bownes, 2005, Boyd et al., 2011, Kwon et al., 2010, Kim et al., 2010, Umehara et al., 2010, Jones et al., 2008, Biteau et al., 2008, Keller et al., 2011, Balakireva et al., 2006, Lee et al., 2006, Inamdar et al., 2012, Vadász et al., 2012, Ahn et al., 2012, Sinenko et al., 2011, Jemc et al., 2012, Förster and Luschnig, 2012, Graves et al., 2012, Senthilan et al., 2012, Gonda et al., 2012, Marchal et al., 2012, Lu et al., 2012) Bsk (Mattila et al., 2005, Richter et al., 2011, Singh et al., 2010, Liebl and Featherstone, 2008, Bond et al., 2008, Biteau et al., 2010, Karpac et al., 2011, Williams et al., 2006, Ayaz et al., 2008, Franciscovich et al., 2008, Liu et al., 2009, Rodahl et al., 2009, Jiang et al., 2009, Igaki et al., 2006, Glavic et al., 2009, Geuking et al., 2009, Tuxworth et al., 2009, Wang et al., 2010, Oliva and Sierralta, 2010, Chen et al., 2012, Bond et al., 2008, Baek et al., 2012, Bangi et al., 2012, Stevens and Page-McCaw, 2012) BSK (Wang et al., 2012) CG5680 (Morrison et al., 2000, Rogers et al., 2003, Sun et al., 2010, Bossuyt et al., 2009, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2008, Ni et al., 2010.12.1, Ni et al., 2011.7.19) DBSK/JNK (Chen et al., 2002) DJNK (Miotto et al., 2006, Scuderi and Letsou, 2005, Jindra et al., 2004, Varfolomeev and Ashkenazi, 2004, Yang et al., 2003, Ballew et al., 2003, Kurz and Ewbank, 2003, Hudson and Cooley, 2002, Taru et al., 2002, Van Aelst and Symons, 2002, Goberdhan and Wilson, 2002, Manfruelli et al., 2002, Kim et al., 2002, Botella et al., 2001, Manfruelli et al., 2001, Weitzman, 2000, Lee et al., 2000, Goberdhan et al., 1999, Davis, 1996.3.8, Davis, 1996.3.8, Davis, 1996.2.15, Davis, 1996.2.13, Adachi-Yamada et al., 1999, Goberdhan and Wilson, 1998, Minden and Karin, 1997, Ip and Davis, 1998, Buckingham and Dexter, 1997, Fields and Montell, 1998, Van Aelst and D'Souza-Schorey, 1997, Riesgo-Escovar and Hafen, 1997, Goberdhan et al., 1997, Wilson et al., 1997, Sluss et al., 1996, Riesgo-Escovar et al., 1996, Chung et al., 2010, Sun et al., 2008, Sluss and Davis, 1997, Sekine et al., 2012, Vadász et al., 2012) dJNK (Kuranaga et al., 2002, Kulansky Poltilove et al., 2000, Sano et al., 2005, Bond and Foley, 2009, Mattila et al., 2008, Gowda et al., 2012) D-JNK (Lorenzen et al., 2003, Han et al., 1998, Ryabinina et al., 2006) DJNK/bsk (Otto et al., 2000) D-junk (Riesgo-Escovar et al., 1995) JNK (Guntermann et al., 2009, Cui et al., 2008, Biswas et al., 2006, Bjorklund et al., 2006, Mueller et al., 2005, Ip, 2005, Udomsinprasert et al., 2004, Anonymous, 2005, Wang et al., 2003, Hay and Guo, 2003, Ishimaru et al., 2004, Muller and Littlewood-Evans, 2001, Kockel et al., 2001, Igaki et al., 2005, Hay et al., 2004, Yeo and Gautier, 2004, Donaldson and Duronio, 2004, Secombe et al., 2004, Brennan and Anderson, 2004, Seyedoleslami Esfahani et al., 2003, Chen et al., 2004, Pilcher, 2004, Park et al., 2004, Wells and Johnston, 2004, McClure and Schubiger, 2004, Miotto et al., 2004, Solnica-Krezel and Eaton, 2003, Hoffmann, 2003, Lee et al., 2003, Kuranaga et al., 2002, Sathyanarayana et al., 2003, Jasper and Bohmann, 2002, Sathyanarayana et al., 2002, Noselli, 2002, Fashena and Thomas, 2000, Settleman, 2001, Tree et al., 2002, Mlodzik, 2002, Galis et al., 2002, Aigaki et al., 2002, Wedlich, 2002, Parkhurst and Delidakis, 2003, Muller et al., 2002, Adachi-Yamada and O'Connor, 2002, Pandur et al., 2002, Verheyen et al., 2002, Liu and Moffat, 2002, Ramet et al., 2002, Pastor-Pareja et al., 2001, Novak and Dedhar, 1999, Reed et al., 2001, Pastor-Pareja et al., 2001, Tootle and Rebay, 2001, Morrison et al., 2000, McEwen and Peifer, 2000, Sokol, 2000, Seidensticker and Behrens, 2000, Behrens, 2000, Perrimon and Stern, 1999, Mlodzik, 1999, Stronach and Perrimon, 1999, Yeaman et al., 1999, Spana and Perrimon, 1999, Feiguin et al., 1998, Blair, 1999, Boutros et al., 1998, Jarvis and Schaefer, 1997, Hall, 1998, Martin-Blanco et al., 1998, Strutt et al., 1997, Anonymous, 1997, Kockel et al., 1997, Hou et al., 1997, Harden et al., 1996, Bosch et al., 2005, Kuttenkeuler et al., 2005, Vidal et al., 2006, Singh and Choi, 2006, Luo et al., 2006, Mace et al., 2005, Cinnamon et al., 2007, Sage et al., 2007, Delaney et al., 2006, Dionne et al., 2006, Maurange et al., 2006, Herz et al., 2006, Kadrmas et al., 2004, Kanao et al., 2012, Kang et al., 2012, Balakireva et al., 2007, Kronhamn et al., 2007, Bovolenta et al., 2006, Chen et al., 2010, Waterhouse et al., 2007, Kirchner et al., 2007, Jordan et al., 2006, Wu et al., 2008, Domingues and Ryoo, 2008, Halme et al., 2008, Sage et al., 2008, McNamee and Brodsky, 2008, Sackton et al., 2007, Fernández et al., 2007, Meller et al., 2005, Mehlen et al., 2005, Lecuit and Le Goff, 2007, Ohsawa et al., 2011, Homsy et al., 2006, Wech and Nagel, 2005, Williams, 2009, Abu-Dayyeh et al., 2010, Apidianakis et al., 2009, Bhuin and Roy, 2010, Lee et al., 2010, Milton et al., 2011, Umemori et al., 2009, Bakal et al., 2008, Horiuchi et al., 2007, Llense and Martín-Blanco, 2008, Melani et al., 2008, Lee et al., 2008, Bidla et al., 2007, Liu et al., 2009, Bossuyt et al., 2009, Rodahl et al., 2009, Diangelo et al., 2009, List et al., 2009, Lee et al., 2010, Hong et al., 2009, Glavic et al., 2009, Wu et al., 2009, Grima et al., 2008, Berger et al., 2008, Rallis et al., 2010, Etter et al., 2005, Tuxworth et al., 2009, Haghayeghi et al., 2010, Jimenez-Del-Rio et al., 2008, Gettings et al., 2010, Franciscovich et al., 2008, Wu et al., 2009, Warner et al., 2010, Tamori et al., 2010, Neisch et al., 2010, Froldi et al., 2010, Cordero et al., 2010, Yavari et al., 2010, Ashton-Beaucage et al., 2010, Xiong et al., 2010, Mattila et al., 2005, Benitez et al., 2010, Lee et al., 2009, Buchon et al., 2010, Suganuma et al., 2010, Falzone et al., 2010, Sekine et al., 2011, Kim et al., 2010, Lee et al., 2008, Jones et al., 2008, Keller et al., 2011, Nam et al., 2012, Bond and Foley, 2012, Lee et al., 2006, Shlevkov and Morata, 2012, Gowda et al., 2012, Stevens and Page-McCaw, 2012, Wang et al., 2012, Gonda et al., 2012, Liu et al., 2007, Spedale et al., 2012, Pallavi et al., 2012) jnk (Wang et al., 2005, Uhlirova and Bohmann, 2006, Sage et al., 2006, Zhou et al., 2005, Leptin, 2005, Lauwers et al., 2009) Jnk (Parrott et al., 2011, Kim et al., 2005, Nechipurenko and Broihier, 2012) JNK/SAPK (Boutros and Mlodzik, 1999) Junk   SAPKa (Kultz, 1998)
Name Synonym	basket (Riesgo-Escovar, 1996.10.3, Riesgo-Escovar and Hafen, 1997, Halme and Hariharan, 2007, Walther and Pichaud, 2007, Herz et al., 2006, Kadrmas et al., 2004, Yoshioka et al., 2008, Scuderi and Letsou, 2005, Kang et al., 2012, Pfleger et al., 2007, Lennox and Stronach, 2010, Neuman-Silberberg, 2007, Cerrato et al., 2006, Sinenko et al., 2011, Wu et al., 2008, Sato et al., 2006, Sackton et al., 2007, Hashimoto and Yamaguchi, 2006, Homsy et al., 2006, Wech and Nagel, 2005, Montrasio et al., 2007, Hwang et al., 2010, Fiehler and Wolff, 2008, Lee et al., 2005, Melani et al., 2008, Babcock et al., 2008, Bidla et al., 2007, Williams et al., 2007, Mok et al., 2005, Rodahl et al., 2009, Corl et al., 2009, Buchon et al., 2009, Weake et al., 2009, Sawamura and Yamamoto, 2004, Shen and Ganetzky, 2009, Grima et al., 2008, Berger et al., 2008, Owusu-Ansah and Banerjee, 2009, Leong et al., 2009, Gettings et al., 2010, Froldi et al., 2010, Zhao et al., 2010, Yavari et al., 2010, Bergantiños et al., 2010, Peralta et al., 2007, Terashima and Bownes, 2005, Boyd et al., 2011, Lee et al., 2006, Inamdar et al., 2012, Vadász et al., 2012, Sinenko et al., 2011, Jemc et al., 2012) Basket (Williams and Hultmark, 2007, Rogers et al., 2003, Ohayon et al., 2009, Orr et al., 2008, Neisch et al., 2010, Horiuchi et al., 2007, Llense and Martín-Blanco, 2008, Williams et al., 2006, Bossuyt et al., 2009, Hull-Thompson et al., 2009, Shimizu et al., 2008, Glavic et al., 2009, Rallis et al., 2010, Kim et al., 2005, Oliva and Sierralta, 2010, Radyuk et al., 2010, Chen et al., 2012, Bond et al., 2008, Mathew et al., 2011, Pallavi et al., 2012) c-Jun aminoterminal kinase (Lee et al., 2010) c-Jun-N-terminal Kinase (Mehlen et al., 2005) c-Jun N-terminal kinase (Umemori et al., 2009, Williams et al., 2007, Rodahl et al., 2009, Lee et al., 2010, Warner et al., 2010, Buchon et al., 2010, Lee et al., 2006, Vadász et al., 2012) JNK (Collins et al., 2006) Jun kinase (Lecuit, 2003, Humbert et al., 2003, Ming et al., 2008, Li and Baker, 2007, Spedale et al., 2012) Jun-kinase (Parkhurst and Delidakis, 2003, Parrott et al., 2011) JUN kinase (Kim et al., 2010) Jun NH2-terminal Kinase (Glavic et al., 2009) Jun N-terminal kinase (Bidla et al., 2007, Maurange et al., 2006, Baehrecke, 2006, Wu et al., 2008, Lecuit and Le Goff, 2007, Taniguchi et al., 2007, Williams et al., 2006, Bossuyt et al., 2009) Jun-N-terminal Kinase (Halme et al., 2008) Jun N-terminal Kinase (Fernández et al., 2007, Froldi et al., 2010, Mattila et al., 2005) pJNK (Ahn et al., 2012)
Secondary FlyBase IDs
	FBgn0015248 FBgn0032199
References ( 549 )
Generate a list of	All references relating to this gene ( 549 )
List References by type	Research paper  ( 353 ) Supplementary material  ( 17 ) Review  ( 81 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 62 ) FlyBase analysis  ( 2 ) Conference report  ( 3 ) DNA/RNA sequence record  ( 5 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Letter  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 72 )
	Castillo et al., 2013, J. Insect Physiol. 59(2): 179--185 Immune gene transcription in Drosophila adult flies infected by entomopathogenic nematodes and their mutualistic bacteria. [FBrf0220790] Enomoto and Igaki, 2013, EMBO Rep. 14(1): 65--72 Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. [FBrf0220433] Rudrapatna et al., 2013, EMBO Rep. 14(2): 172--177 Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. [FBrf0220676] Ahn et al., 2012, Dev. Comp. Immunol. 38(3): 466--473 JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection. [FBrf0219778] Baek et al., 2012, FEBS Lett. 586(6): 772--777 Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing. [FBrf0217868] Bangi et al., 2012, EMBO Rep. 13(6): 569--576 Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. [FBrf0218473] Bond and Foley, 2012, J. Biol. Chem. 287(33): 27359--27370 Autocrine Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) Pathway Activity Controls Intestinal Stem Cell Proliferation in the Adult Drosophila Midgut. [FBrf0219176] Brock et al., 2012, J. Cell Sci. 125(23): 5667--5676 Transcriptional regulation of Profilin during wound closure in Drosophila larvae. [FBrf0220862] Chatterjee and Bohmann, 2012, PLoS ONE 7(4): e34063 A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture. [FBrf0218067] Chen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 484--489 Tumor suppression by cell competition through regulation of the Hippo pathway. [FBrf0217148] Chen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(29): 11842--11847 Axon injury and stress trigger a microtubule-based neuroprotective pathway. [FBrf0218884] Defays and Bertoli, 2012, Alcohol 46(8): 737--745 Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. [FBrf0220080] Dekanty et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20549--20554 Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. [FBrf0220285] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Gonda et al., 2012, PLoS ONE 7(7): e42369 Drosophila Heat Shock Response Requires the JNK Pathway and Phosphorylation of Mixed Lineage Kinase at a Conserved Serine-Proline Motif. [FBrf0219015] Gowda et al., 2012, J. Biol. Chem. 287(21): 17554--17567 p53 Binding Prevents Phosphatase-mediated Inactivation of Diphosphorylated c-Jun N-terminal Kinase. [FBrf0218361] Graves et al., 2012, PLoS ONE 7(6): e37615 Notch signaling activates yorkie non-cell autonomously in Drosophila. [FBrf0218547] Hong et al., 2012, Biochem. Biophys. Res. Commun. 419(1): 49--53 Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model. [FBrf0217666] Inamdar et al., 2012, Parkinsons Dis. 2012: 938528 The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds. [FBrf0219235] Jemc et al., 2012, Dev. Biol. 367(2): 114--125 raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis. [FBrf0218557] Kanao et al., 2012, PLoS ONE 7(2): e30958 The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. [FBrf0217639] Kang et al., 2012, Nat. Cell Biol. 14(4): 409--415 CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. [FBrf0217924] Lu et al., 2012, PLoS Biol. 10(7): e1001357 Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells. [FBrf0218889] Ma et al., 2012, Cell Res. 22(2): 425--431 NOPO modulates Egr-induced JNK-independent cell death in Drosophila. [FBrf0217390] Marchal et al., 2012, PLoS ONE 7(3): e34310 The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling. [FBrf0218002] Mozer and Sandstrom, 2012, Mol. Cell. Neurosci. 51(3-4): 89--100 Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase. [FBrf0219839] Nam et al., 2012, EMBO J. 31(5): 1253--1265 Genetic evidence of a redox-dependent systemic wound response via Hayan Protease-Phenoloxidase system in Drosophila. [FBrf0217593] Nechipurenko and Broihier, 2012, J. Cell Biol. 196(3): 345--362 FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. [FBrf0217391] Ohsawa et al., 2012, Nature 490(7421): 547--551 Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. [FBrf0219780] Pallavi et al., 2012, EMBO J. 31(13): 2895--2907 Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. [FBrf0218851] Pezzulo et al., 2012, PLoS ONE 7(8): e43777 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363] Sekine et al., 2012, Mol. Cell 48(5): 692--704 The Kelch Repeat Protein KLHDC10 Regulates Oxidative Stress-Induced ASK1 Activation by Suppressing PP5. [FBrf0220253] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Seong et al., 2012, J. Radiat. Res. 53(2): 242--249 Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation. [FBrf0218044] Shaukat et al., 2012, PLoS ONE 7(10): e47447 A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [FBrf0219770] Shlevkov and Morata, 2012, Cell Death Differ. 19(3): 451--460 A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila. [FBrf0217451] Spindler et al., 2012, PLoS ONE 7(2): e29782 Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [FBrf0217656] Stevens and Page-McCaw, 2012, Mol. Biol. Cell 23(6): 1068--1079 A secreted MMP is required for reepithelialization during wound healing. [FBrf0217752] Takahama et al., 2012, Biochem. Biophys. Res. Commun. 417(2): 807--811 Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila. [FBrf0217240] Tauc et al., 2012, genesis 50(6): 466--481 A role for Drosophila Wnt-4 in heart development. [FBrf0218607] Tsuzuki et al., 2012, Sci. Rep. 2: 210 Drosophila growth-blocking peptide-like factor mediates acute immune reactions during infectious and non-infectious stress. [FBrf0217467] Vadász et al., 2012, PLoS ONE 7(10): e46696 Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction. [FBrf0219640] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Wang et al., 2012, PLoS ONE 7(6): e38569 Essential Roles of the Tap42-Regulated Protein Phosphatase 2A (PP2A) Family in Wing Imaginal Disc Development of Drosophila melanogaster. [FBrf0218627] Yoshioka et al., 2012, genesis 50(8): 599--611 Drosophila DREF acting via the JNK pathway is required for thorax development. [FBrf0219198] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Brumby et al., 2011, Genetics 188(1): 105--125 Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis. [FBrf0213630] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Guntermann and Foley, 2011, J. Biol. Chem. 286(35): 30284--30294 The Protein Dredd Is an Essential Component of the c-Jun N-terminal Kinase Pathway in the Drosophila Immune Response. [FBrf0214801] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. [FBrf0216680] Karpac et al., 2011, Dev. Cell 20(6): 841--854 Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. [FBrf0213873] Keller et al., 2011, Neuron 72(5): 760--775 Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. [FBrf0216904] Kuranaga et al., 2011, Development 138(8): 1493--1499 Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. [FBrf0213320] Maher et al., 2011, Hum. Mol. Genet. 20(2): 261--270 ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. [FBrf0212618] Marinho et al., 2011, Development 138(2): 349--357 The Drosophila Nol12 homologue viriato is a dMyc target that regulates nucleolar architecture and is required for dMyc-stimulated cell growth. [FBrf0212565] Mathew et al., 2011, Mol. Cell. Biol. 31(24): 4978--4993 Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. [FBrf0216703] Milton et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(42): 17521--17526 Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. [FBrf0216440] Moskalev et al., 2011, Biogerontology 12(3): 253--263 Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. [FBrf0213740] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Parrott et al., 2011, PLoS ONE 6(9): e25087 Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster. [FBrf0216255] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Robinson and Moberg, 2011, Cell Cycle 10(23): 4110--4118 Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. [FBrf0217243] Seisenbacher et al., 2011, PLoS Genet. 7(8): e1002168 MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress. [FBrf0214607] Sekine et al., 2011, J. Cell Sci. 124(17): 3006--3016 p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. [FBrf0215011] Sinenko et al., 2011, EMBO Rep. 13(1): 83--89 Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. [FBrf0217071] Suissa et al., 2011, J. Biol. Chem. 286(17): 15556--15564 The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation. [FBrf0213516] Sun and Irvine, 2011, Dev. Biol. 350(1): 139--151 Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. [FBrf0212753] Tripura et al., 2011, Int. J. Dev. Biol. 55(6): 583--590 Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila. [FBrf0216296] Vanzomeren-Dohm et al., 2011, BMC Dev. Biol. 11: 41 The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor. [FBrf0214535] Wertheim et al., 2011, Mol. Ecol. 20(5): 932--949 Functional genomics of the evolution of increased resistance to parasitism in Drosophila. [FBrf0213049] Zhao et al., 2011, J. Biol. Chem. 286(8): 6211--6218 Antimicrobial Peptides Increase Tolerance to Oxidant Stress in Drosophila melanogaster. [FBrf0213053] Show all research papers ...
Recent reviews ( 1 )
	Spedale et al., 2012, Genes Dev. 26(6): 527--541 ATAC-king the complexity of SAGA during evolution. [FBrf0219841] Show all reviews ...