FB2025_02 , released April 17, 2025
Gene: Dmel\bsk
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General Information
Symbol
Dmel\bsk
Species
D. melanogaster
Name
basket
Annotation Symbol
CG5680
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000229
Gene Model Status
Current
Stock Availability
31 publicly available
Enzyme Name (EC)
mitogen-activated protein kinase (2.7.11.24)
Gene Summary
basket (bsk) encodes a serine/threonine-protein kinase, a key component of JNK pathway that phosphorylates the transcription factor encoded by Jra. Its roles include regulation of cell shape and stress response. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

JNK, DJNK, Jun N-terminal kinase, c-Jun N-terminal kinase, pJNK

Key Links
Genomic Location
Cytogenetic map
31B1-31B1
Sequence location
Recombination map
2-40
RefSeq locus
NT_033779 REGION:10247502..10250501
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (52 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables JUN kinase activity
inferred from direct assay
(Riesgo-Escovar et al., 1996, Sluss et al., 1996)
inferred from mutant phenotype
(Botella et al., 2001)
enables protein binding
inferred from physical interaction with FLYBASE:Tak1; FB:FBgn0026323
(Das et al., 2023)
inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323
(Chen et al., 2002)
enables protein kinase activity
inferred from direct assay
(Riesgo-Escovar and Hafen, 1997)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR003527, InterPro:IPR008351
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR008351
(InterPro Project Members, 2004-)
enables JUN kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001171982
(GO Reference Genome Project, 2011-)
enables MAP kinase activity
inferred from electronic annotation with InterPro:IPR003527, InterPro:IPR008351
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR008351
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
Biological Process (43 terms)
Terms Based on Experimental Evidence (43 terms)
CV Term
Evidence
References
involved_in antibacterial humoral response
inferred from direct assay
(Sluss et al., 1996)
involved_in axon extension
inferred from mutant phenotype
(Srahna et al., 2006)
involved_in axon guidance
inferred from direct assay
(Soares et al., 2014)
involved_in cellular response to arsenic-containing substance
inferred from direct assay
(Ryabinina et al., 2006)
involved_in cellular response to cadmium ion
inferred from direct assay
(Ryabinina et al., 2006)
involved_in cellular response to oxidative stress
inferred from mutant phenotype
(Wu et al., 2009)
involved_in cellular response to reactive oxygen species
inferred from direct assay
(Ryabinina et al., 2006)
involved_in chorion micropyle formation
inferred from mutant phenotype
(Suzanne et al., 2001)
involved_in collateral sprouting of injured axon
inferred from mutant phenotype
(Xiong et al., 2010)
involved_in defense response to Gram-negative bacterium
inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291
(Soory and Ratnaparkhi, 2022)
involved_in determination of digestive tract left/right asymmetry
inferred from genetic interaction with FLYBASE:puc; FB:FBgn0243512
(Taniguchi et al., 2007)
involved_in dorsal appendage formation
inferred from mutant phenotype
(Suzanne et al., 2001)
involved_in dorsal closure, spreading of leading edge cells
inferred from mutant phenotype
(Kushnir et al., 2017)
involved_in dorsal closure
inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291
(Riesgo-Escovar and Hafen, 1997)
inferred from mutant phenotype
(Riesgo-Escovar et al., 1996)
involved_in embryonic anterior midgut (ectodermal) morphogenesis
inferred from genetic interaction with FLYBASE:puc; FB:FBgn0243512
(Taniguchi et al., 2007)
involved_in engulfment of apoptotic cell
inferred from mutant phenotype
(Etchegaray et al., 2012)
involved_in establishment or maintenance of cell polarity regulating cell shape
inferred from mutant phenotype
(Park et al., 2019)
involved_in follicle cell of egg chamber development
inferred from mutant phenotype
(Jordan et al., 2006)
involved_in imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Ishimaru et al., 2004, Cha et al., 2003)
involved_in imaginal disc-derived male genitalia morphogenesis
inferred from mutant phenotype
(Kuranaga et al., 2011)
involved_in JNK cascade
inferred from mutant phenotype
(Wang et al., 2022)
inferred from direct assay
(Ishimaru et al., 2004, Riesgo-Escovar et al., 1996, Sluss et al., 1996)
involved_in long-term memory
inferred from genetic interaction with FLYBASE:hiw; FB:FBgn0030600
(Huang et al., 2012)
involved_in melanization defense response
inferred from mutant phenotype
(Bidla et al., 2007)
inferred from genetic interaction with FLYBASE:mei-9; FB:FBgn0002707
(Karpac et al., 2011)
involved_in mushroom body development
inferred from mutant phenotype
(Bornstein et al., 2015)
involved_in neuron development
inferred from mutant phenotype
(Rallis et al., 2010)
involved_in neuron projection morphogenesis
inferred from mutant phenotype
(Rallis et al., 2010)
involved_in peptidoglycan recognition protein signaling pathway
inferred from mutant phenotype
(Wagner et al., 2021, Valanne et al., 2007, Delaney et al., 2006, Silverman et al., 2003)
acts_upstream_of positive regulation of apoptotic process
inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323
(Das et al., 2023)
acts_upstream_of positive regulation of autophagy
inferred from mutant phenotype
(Wu et al., 2009)
involved_in positive regulation of border follicle cell migration
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Mathieu et al., 2007)
inferred from mutant phenotype
(Melani et al., 2008)
involved_in positive regulation of cell population proliferation
inferred from mutant phenotype
(Xu et al., 2023)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Sorrosal et al., 2010)
involved_in positive regulation of neuron remodeling
inferred from genetic interaction with FLYBASE:wgn; FB:FBgn0030941,FLYBASE:grnd; FB:FBgn0032682
(Zheng et al., 2025)
inferred from mutant phenotype
(Bornstein et al., 2015)
acts_upstream_of positive regulation of programmed cell death
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Li et al., 2019, Sun et al., 2019, Chabu and Xu, 2014, Kanda et al., 2011, Geuking et al., 2005, Igaki et al., 2002, Moreno et al., 2002)
inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323
(Xue et al., 2007)
involved_in regulation of cellular response to phosphate starvation
inferred from genetic interaction with UniProtKB:Q9VRR2
(Xu et al., 2023)
involved_in regulation of wound healing, spreading of epidermal cells
inferred from mutant phenotype
(Park et al., 2019)
involved_in response to heat
inferred from mutant phenotype
(Karpac et al., 2009)
involved_in response to oxidative stress
inferred from mutant phenotype
(Karpac et al., 2009)
involved_in tumor necrosis factor-mediated signaling pathway
inferred from genetic interaction with FLYBASE:wgn; FB:FBgn0030941,FLYBASE:grnd; FB:FBgn0032682
(Zheng et al., 2025)
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Li et al., 2019, Sun et al., 2019, Chabu and Xu, 2014, Kanda et al., 2011, Geuking et al., 2005, Igaki et al., 2002, Moreno et al., 2002)
inferred from genetic interaction with FLYBASE:Tak1; FB:FBgn0026323
(Das et al., 2023, Xue et al., 2007)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from direct assay
(Ishimaru et al., 2004)
involved_in wound healing, spreading of epidermal cells
inferred from mutant phenotype
(Galko and Krasnow, 2004)
involved_in wound healing
inferred from direct assay
(Ramet et al., 2002)
inferred from mutant phenotype
(Bosch et al., 2005)
NOT involved_in cellular response to starvation
inferred from mutant phenotype
(Wu et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in JNK cascade
inferred from biological aspect of ancestor with PANTHER:PTN001171982
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Bornstein et al., 2015, Rallis et al., 2010)
located_in dendrite
inferred from direct assay
(Rallis et al., 2010)
located_in nucleus
inferred from direct assay
(Chittaranjan et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (P92208)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
MAP kinase activity
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.24)
(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.24)
Summaries
Gene Snapshot
basket (bsk) encodes a serine/threonine-protein kinase, a key component of JNK pathway that phosphorylates the transcription factor encoded by Jra. Its roles include regulation of cell shape and stress response. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES -
Conventional Mitogen-activated protein kinases (MAPK) are proline-directed protein serine/threonine kinases that are components of the MAPK signaling cascade. MAPKs are activated by dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop by MAPK kinases. (Adapted from PMID:21372320).
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
TNFα-Eiger Signaling Pathway Core Components -
The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)
Protein Function (UniProtKB)
Mitogen-activated protein kinase and key component of the c-Jun N-terminal kinase (JNK) pathway which phosphorylate and activate transcription factors involved in a wide range of biological processes including response to various stresses, cellular proliferation, differentiation and migration, and regulation of cell shape (PubMed:10433922, PubMed:11784101, PubMed:22227521, PubMed:25594180, PubMed:28396149, PubMed:37138087, PubMed:8946915, PubMed:9224720). Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity (PubMed:9224720). Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis (PubMed:10433922, PubMed:11784101, PubMed:8946915, PubMed:9224720). Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade (PubMed:22227521). During epidermal wound healing involved in cellular polarization by inducing the translocation of sktl and mys/integrin beta to the trailing edge (PubMed:31704968). Exhibits cytoprotective activity in neuronal cells in response to wounding to the integument (PubMed:22227521). Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure (PubMed:10433922, PubMed:11784101). Regulates the activity of SREBP in neurons and thereby the accumulation of lipids in glia (PubMed:25594180). Plays a role in positively regulating the expression of DIP2 independently of AP-1, thereby ensuring proper axon guidance in mushroom bodies (PubMed:28396149). In enterocytes and differentiating progenitors of the gut that are experiencing inorganic phosphate (Pi) deficiency, activated by Cka to induce nearby progenitor cells to proliferate and form new absorptive cells, probably helping the organism to cope with the nutrient deficiency by maximizing absorption of dietary Pi (PubMed:37138087).
(UniProt, P92208)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
bsk: basket
Homozygous lethal; embryos have large dorsal anterior hole.
Summary (Interactive Fly)

MAP kinase homolog - regulates cell shape change and epidermal layer movement during dorsal closure - developmental axon pruning requires destabilization of cell adhesion by JNK signaling - Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\bsk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P92208)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bsk-RB
FBtr0080087
NM_164900
1535
372
bsk-RE
FBtr0300982
NM_001169461
1655
372
bsk-RF
FBtr0302378
NM_001169459
1797
372
Additional Transcript Data and Comments
Reported size (kB)

1.5 (northern blot)

(Riesgo-Escovar et al., 1996)

1.85, 1.8 (northern blot)

(Sluss et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
bsk-PB
FBpp0079676
43.0
372
6.39
P92208
NP_723541
AAF52883
bsk-PE
FBpp0290204
43.0
372
6.39
P92208
NP_001162932
ACZ94221
bsk-PF
FBpp0291573
43.0
372
6.39
P92208
NP_001162930
ACZ94220
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

372 aa isoforms: bsk-PB, bsk-PE, bsk-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

353 (aa); 49 (kD observed); 49 (kD predicted)

(Riesgo-Escovar et al., 1996)

372 (aa)

(Sluss et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with MKP-4 (via tyrosine-protein phosphatase domain); the interaction dephosphorylates bsk.

(UniProt, P92208)
Post Translational Modification

Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme.

(UniProt, P92208)
Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

(UniProt, P92208)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bsk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.93

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism | ubiquitous
(Riesgo-Escovar et al., 1996)
embryonic stage 6 -- 7
posterior transverse furrow
(Riesgo-Escovar et al., 1996)
cephalic furrow
(Riesgo-Escovar et al., 1996)
anterior transverse furrow
(Riesgo-Escovar et al., 1996)
embryonic stage 8 -- 17
presumptive embryonic/larval central nervous system
(Riesgo-Escovar et al., 1996)
presumptive embryonic/larval peripheral nervous system
(Riesgo-Escovar et al., 1996)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
eye disc
(Sluss et al., 1996)
imaginal disc
(Riesgo-Escovar et al., 1996)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic epidermis
(Sluss et al., 1996)
embryonic brain
(Sluss et al., 1996)
presumptive embryonic/larval central nervous system
(Sluss et al., 1996)
presumptive embryonic/larval peripheral nervous system
(Sluss et al., 1996)
embryonic stage & larval stage & pupal stage
(Sluss et al., 1996)
embryonic stage 1 -- 9
organism
(Sluss et al., 1996)
third instar larval stage
wing disc
(Sluss et al., 1996)
imaginal disc
(Sluss et al., 1996)
adult stage | female
(Sluss et al., 1996)
adult stage | male
(Sluss et al., 1996)
fat body
(Sluss et al., 1996)
hemocyte
(Sluss et al., 1996)
Additional Descriptive Data

bsk is expressed ubiquitously at low levels in early embryos. During gastrulation, high levels of bsk mRNA are expressed in cells involved in morphogenetic movements; the cephalic furrow, the anterior and posterior transverse folds, and the leading edge of the ventrolateral epidermis. Begininning in stages 8-9, expression is observed in the CNS and PNS. Expression persists in the CNS through larval stages. Expression is also observed in imaginal discs.

(Riesgo-Escovar et al., 1996)

bsk transcripts are present at a low level in early cleavage stage embryos. During germ band extension, bsk transcripts are present in all germ layers. During germ band retraction, intense staining is seen in the epidermis and in the CNS. At stage 14, staining is increased in the CNS and is present in the lateral epidermis extending up to the amnioserosa. At stage 15, strong staining is observed in the CNS, the brain, and some peripheral neurons. Strong staining persists in the fully retracted CNS at stage 16. bsk expression is also observed in third instar larval imaginal discs. High levels of bsk transcripts are seen in the eye and wing imaginal discs. On northern blots, bsk transcripts are observed at all stages of development as well as in fat body and in a hemocyte cell line.

(Sluss et al., 1996)

The 1.85kb bsk transcript is detected in early embryos.

(Sluss et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage -- adult stage
Kenyon cell
• axon
(Bornstein et al., 2015)
adult stage
adult mushroom body
• axon
(Rallis et al., 2010)
adult antennal lobe
• axon
(Rallis et al., 2010)
ellipsoid body
(Rallis et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

bsk protein is detected in the axons of Kenyon cells but not in the cell bodies or dendrites.

(Bornstein et al., 2015)

bsk protein was detected with an antibody to human JNK1. High levels of active phosphorylated protein were found in adult mushroom body axons. High bsk levels were also observed in the antennal lobe and ellipsoid body. bsk was found in axons throughout development from wandering third instar larval through adult stages.

(Rallis et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Bornstein et al., 2015, Rallis et al., 2010)
located_in dendrite
inferred from direct assay
(Rallis et al., 2010)
located_in nucleus
inferred from direct assay
(Chittaranjan et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bsk in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 40 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bsk
Transgenic constructs containing regulatory region of bsk
Aberrations (Deficiencies and Duplications) ( 17 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL469B
lethal, with Scer\GAL4e22c
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4Tub.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
fertile
Other Phenotypes
Allele
abnormal cell death | adult stage | nutrition conditional, with Scer\GAL4GR1
abnormal cell death | nutrition conditional, with Scer\GAL4GR1
abnormal neuroanatomy, with Scer\GAL4ato.3.6
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4ey-OK107
abnormal neuroanatomy, with Scer\GAL4GMR.PF
abnormal neuroanatomy, with Scer\GAL4Tab2-201Y, Scer\GAL4UAS.cHa
abnormal neuroanatomy | adult stage, with Scer\GAL4ato.3.6
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR71G10
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4repo
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | conditional, with Scer\GAL4tey-5053A
abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4elav-C155
abnormal neuroanatomy | progressive | somatic clone
abnormal neuroanatomy | P-stage, with Scer\GAL4ppk.PU
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal neuroanatomy | third instar larval stage | conditional, with Scer\GAL4tey-5053A
abnormal neurophysiology, with Scer\GAL4elav-C155
abnormal oxidative stress response | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
abnormal planar polarity, with Scer\GAL4hs.2sev
abnormal planar polarity, with Scer\GAL4pnr-MD237
abnormal size | larval stage, with Scer\GAL4A58
abnormal size | larval stage, with Scer\GAL4dome-PG14
abnormal starvation stress response | adult stage, with Scer\GAL4NP0001
abnormal stress response, with Scer\GAL4da.G32
abnormal stress response, with Scer\GAL4Ilp2.PR
abnormal stress response | adult stage, with Scer\GAL4repo
abnormal stress response | RU486 conditional, with Scer\GAL4Ilp2.Switch.PK
abnormal wound healing, with Scer\GAL4A58
abnormal wound healing, with Scer\GAL4elav.Switch.PO
abnormal wound healing, with Scer\GAL4en-e16E
abnormal wound healing, with Scer\GAL4αTub84B.Switch.PK
abnormal wound healing | larval stage, with Scer\GAL4221
abnormal wound healing | larval stage, with Scer\GAL4A58
chemical resistant, with Scer\GAL4arm.PS
chemical resistant, with Scer\GAL4ple.PF
chemical sensitive | dominant
decreased cell growth rate, with Scer\GAL4sd-SG29.1
decreased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
decreased cell size | larval stage | conditional, with Scer\GAL4A58
decreased occurrence of cell division | adult stage, with Scer\GAL4NP5130
decreased occurrence of cell division | adult stage, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4bun-GSG5961
decreased size | adult stage, with Scer\GAL4ptc.PU
increased cell death, with Scer\GAL4sd-SG29.1
increased cell death | embryonic stage, with Scer\GAL4Act5C.PU
increased cell death | embryonic stage, with Scer\GAL4how-24B
increased cell death | larval stage, with Scer\GAL4GMR.PU
increased cell death | third instar larval stage, with Scer\GAL4en.PU
increased cell death | third instar larval stage, with Scer\GAL4ptc.PU
long lived | RU486 conditional, with Scer\GAL4bun-GSG5961
majority die during P-stage, with Scer\GAL4Tub.PU
short lived, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
some die during embryonic stage
some die during embryonic stage | germline clone | maternal effect | maternal effect
some die during embryonic stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4opa
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4ptc.PU
wild-type
Phenotype manifest in
Allele
adult, with Scer\GAL4NP0001
adult gut, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
adult gut | RU486 conditional, with Scer\GAL4bun-GSG5961
adult midgut epithelium, with Scer\GAL4NP5130
adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4Tub.PU
adult olfactory receptor neuron Or42a | conditional, with Scer\GAL4repo
adult optic lobe glial cell | cell non-autonomous, with Scer\GAL4nSyb.PS
adult thorax, with Scer\GAL4ap-md544
adult thorax, with Scer\GAL4opa
alpha/beta Kenyon cell
amnioserosa (with bsk1)
amnioserosa (with bsk2)
antennal lobe glomerulus VM7 | conditional, with Scer\GAL4repo
autophagosome | third instar larval stage | chemical conditional, with Scer\GAL4Act5C.PP
axon, with Scer\GAL4ey-OK107
axon, with Scer\GAL4Tab2-201Y, Scer\GAL4UAS.cHa
axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
axon & dorsal cluster neuron | somatic clone
axon | adult stage
axon | adult stage, with Scer\GAL4GMR71G10
axon | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
axon | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
axon | adult stage, with Scer\GAL4repo
axon | pupal stage | somatic clone
axon | somatic clone
axon | third instar larval stage | conditional, with Scer\GAL4tey-5053A
bouton, with Scer\GAL4elav-C155
cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4dome-PG14
dendrite | larval stage | conditional, with Scer\GAL4221
dendrite | P-stage, with Scer\GAL4ppk.PU
egg chamber | nutrition conditional, with Scer\GAL4GR1
embryo | dorsal, with Scer\GAL469B
embryo | dorsal, with Scer\GAL4e22c
embryo | dorsal closure stage
embryo | dorsal closure stage | germline clone
embryo | embryonic stage 14 (with bsk1)
embryo | embryonic stage 14 (with bsk2)
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | anterior | dorsal
embryonic/first instar larval cuticle | dorsal
embryonic/first instar larval cuticle | dorsal, with Scer\GAL4arm.PS
embryonic/first instar larval cuticle | dorsal | germline clone
embryonic/larval epidermis | larval stage, with Scer\GAL4A58
embryonic/larval epidermis | larval stage | conditional, with Scer\GAL4A58
embryonic/larval fat body | somatic clone, with Scer\GAL4Act.PU
embryonic/larval gut | third instar larval stage | chemical conditional, with Scer\GAL4Act5C.PP
embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4Act5C.PU
embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4lz-gal4
embryonic/larval motor neuron | third instar larval stage | conditional, with Scer\GAL4tey-5053A
embryonic/larval neuromuscular junction | larval stage | conditional, with Scer\GAL4elav-C155
embryonic abdominal segment | dorsal, with Scer\GAL4ptc-559.1
embryonic dorsal epidermis
embryonic dorsal epidermis (with bsk1)
embryonic dorsal epidermis (with bsk2)
embryonic dorsal epidermis (with Df(2L)flp147E)
embryonic epidermis | dorsal
embryonic leading edge cell, with Scer\GAL4arm.PS
embryonic leading edge cell, with Scer\GAL4ptc-559.1
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4αTub84B.PL
eye-antennal disc, with Scer\GAL4GMR.PU
eye photoreceptor cell, with Scer\GAL4GMR.PF
filamentous actin (with bsk1)
filamentous actin (with bsk2)
follicle cell | nutrition conditional, with Scer\GAL4GR1
gamma Kenyon cell
gamma Kenyon cell | adult stage, with Scer\GAL4GMR71G10
gamma Kenyon cell | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.P2
gamma Kenyon cell | adult stage, with Scer\GAL4GMR71G10, Spyo\Cas9UAS.Tag:NLS(Unk)
gamma Kenyon cell | adult stage | somatic clone
intestinal stem cell | adult stage, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
intestinal stem cell | chemical conditional, with Scer\GAL4NP0001
intestinal stem cell | chemical conditional, with Scer\GAL4NP5130
Kenyon cell, with Scer\GAL4ey-OK107
Kenyon cell | pupal stage | somatic clone
Kenyon cell | somatic clone
lamina, with Scer\GAL4GMR.PF
larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4221
larval dorsal multidendritic neuron ddaE | larval stage | conditional, with Scer\GAL4221
larval multidendritic class IV neuron | P-stage, with Scer\GAL4ppk.PU
larval segmental nerve | conditional, with Scer\GAL4tey-5053A
lipid droplet | adult stage | cell non-autonomous, with Scer\GAL4nSyb.PS
male genitalia, with Scer\GAL4en.PU
medulla, with Scer\GAL4ato.3.6
mesonotum, with Scer\GAL4pnr-MD237
mesothoracic cleft | ectopic, with Scer\GAL4ap-md544
microtubule | larval stage, with Scer\GAL4221
microtubule | larval stage | conditional, with Scer\GAL4221
midgut | adult stage, with Scer\GAL4Act.PU
midgut | adult stage, with Scer\GAL4NP5130
mitochondrion
mitotic domain 1 | embryonic stage 13 (with bsk1)
mitotic domain 1 | embryonic stage 13 (with bsk2)
mitotic domain 1 | embryonic stage 15 (with bsk1)
mitotic domain 1 | embryonic stage 15 (with bsk2)
neuroblast | progressive | somatic clone
neuromuscular junction | larval stage, with Scer\GAL4elav-C155
neuron, with Scer\GAL4GMR.PF
nucleus | larval stage, with Scer\GAL4A58
nurse cell | nutrition conditional, with Scer\GAL4GR1
ommatidium, with Scer\GAL4GMR.PU
ommatidium, with Scer\GAL4hs.2sev
ommatidium | somatic clone
peripodial epithelium, with Scer\GAL4opa
peripodial epithelium, with Scer\GAL4Ubx-lac1-Gal4
photoreceptor neuron | somatic clone
synapse, with Scer\GAL4elav-C155
thorax, with Scer\GAL4ap-md544
thorax, with Scer\GAL4pnr-MD237
tract | pupal stage | somatic clone
ventral furrow, with Scer\GAL4twi.PG
wing, with Scer\GAL4ptc.PU
wing disc, with Scer\GAL4Bx-MS1096-KE
wing disc, with Scer\GAL4en-e16E
wing disc | third instar larval stage, with Scer\GAL4ptc.PU
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en.PU
wing nerve, with Scer\GAL4repo
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (45)
Hsap\MAPK8
12 of 14
Yes
Yes
1  
Hsap\MAPK9
11 of 14
No
Yes
1  
Hsap\MAPK10
11 of 14
No
Yes
1  
Hsap\MAPK1
2 of 14
No
No
Hsap\MAPK3
2 of 14
No
No
3  
Hsap\MAPK4
2 of 14
No
No
Hsap\MAPK6
2 of 14
No
No
Hsap\MAPK7
2 of 14
No
No
Hsap\MAPK15
2 of 14
No
No
1  
Hsap\NLK
2 of 14
No
No
2  
Hsap\BUB1B-PAK6
1 of 14
No
No
Hsap\CDK2
1 of 14
No
No
1  
Hsap\CDK3
1 of 14
No
No
Hsap\CDK6
1 of 14
No
No
1  
Hsap\CDK12
1 of 14
No
No
Hsap\CDKL4
1 of 14
No
No
1  
Hsap\CLK1
1 of 14
No
No
Hsap\CLK2
1 of 14
No
No
4  
Hsap\CLK3
1 of 14
No
No
1  
Hsap\CLK4
1 of 14
No
No
1  
Hsap\DYRK1A
1 of 14
No
No
1  
Hsap\DYRK1B
1 of 14
No
No
Hsap\DYRK2
1 of 14
No
No
Hsap\DYRK3
1 of 14
No
No
1  
Hsap\DYRK4
1 of 14
No
No
1  
Hsap\HIPK1
1 of 14
No
No
1  
Hsap\HIPK2
1 of 14
No
No
1  
Hsap\HIPK3
1 of 14
No
No
1  
Hsap\HIPK4
1 of 14
No
No
1  
Hsap\MAPK11
1 of 14
No
No
Hsap\MAPK12
1 of 14
No
No
Hsap\MAPK13
1 of 14
No
No
1  
Hsap\MAPK14
1 of 14
No
No
Hsap\NEK4
1 of 14
No
No
Hsap\NEK8
1 of 14
No
No
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\PAK1
1 of 14
No
No
Hsap\PAK2
1 of 14
No
No
Hsap\PAK3
1 of 14
No
No
Hsap\PAK4
1 of 14
No
No
Hsap\PAK5
1 of 14
No
No
Hsap\PAK6
1 of 14
No
No
Hsap\PINK1
1 of 14
No
No
10  
Hsap\PRPF4B
1 of 14
No
No
Hsap\PSKH1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Mapk8
12 of 14
Yes
Yes
Rnor\Mapk9
11 of 14
No
Yes
Rnor\Mapk10
11 of 14
No
Yes
Rnor\Mapk1
2 of 14
No
No
Rnor\Mapk3
2 of 14
No
No
Rnor\Mapk7
2 of 14
No
No
Rnor\Mapk15
2 of 14
No
No
Rnor\Nlk
2 of 14
No
No
Rnor\LOC365949
1 of 14
No
Yes
Rnor\Mapk4
1 of 14
No
No
Rnor\Mapk6
1 of 14
No
No
Rnor\Mapk11
1 of 14
No
No
Rnor\Mapk12
1 of 14
No
No
Rnor\Mapk13
1 of 14
No
No
Rnor\Mapk14
1 of 14
No
No
Rnor\Pak2
1 of 14
No
No
Rnor\Pak4
1 of 14
No
No
Rnor\Pak5
1 of 14
No
No
Rnor\Pink1
1 of 14
No
No
Rnor\Prag1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (19)
Mmus\Mapk8
12 of 14
Yes
Yes
Mmus\Mapk9
11 of 14
No
Yes
Mmus\Mapk10
10 of 14
No
Yes
Mmus\Mapk1
2 of 14
No
No
Mmus\Mapk3
2 of 14
No
No
Mmus\Mapk7
2 of 14
No
No
Mmus\Mapk15
2 of 14
No
No
Mmus\Nlk
2 of 14
No
No
Mmus\Mapk4
1 of 14
No
No
Mmus\Mapk6
1 of 14
No
No
Mmus\Mapk11
1 of 14
No
No
Mmus\Mapk12
1 of 14
No
No
Mmus\Mapk13
1 of 14
No
No
Mmus\Mapk14
1 of 14
No
No
Mmus\Pak2
1 of 14
No
No
Mmus\Pak4
1 of 14
No
No
Mmus\Pak5
1 of 14
No
No
Mmus\Pink1
1 of 14
No
No
Mmus\Prag1
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (33)
Xtro\mapk8
8 of 13
Yes
Yes
Xtro\mapk10
7 of 13
No
Yes
Xtro\gh2
6 of 13
No
Yes
Xtro\mapk6
2 of 13
No
Yes
Xtro\mapk7
2 of 13
No
No
Xtro\mapk15
2 of 13
No
No
Xtro\nlk.2
2 of 13
No
No
Xtro\nlk
2 of 13
No
No
Xtro\cdk1
1 of 13
No
No
Xtro\cilk1
1 of 13
No
No
Xtro\clk1
1 of 13
No
No
Xtro\clk3
1 of 13
No
No
Xtro\dyrk1a.2
1 of 13
No
No
Xtro\dyrk1a
1 of 13
No
No
Xtro\dyrk2
1 of 13
No
No
Xtro\dyrk3
1 of 13
No
No
Xtro\gpr26
1 of 13
No
No
Xtro\hipk1
1 of 13
No
No
Xtro\hipk2
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\LOC116412424
1 of 13
No
No
Xtro\mapk1
1 of 13
No
No
Xtro\mapk4
1 of 13
No
No
Xtro\mapk13
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\pak2
1 of 13
No
No
Xtro\pak3
1 of 13
No
No
Xtro\pak4
1 of 13
No
No
Xtro\sbds
1 of 13
No
No
Xtro\stk35
1 of 13
No
Yes
Xtro\XB956263
1 of 13
No
No
Xtro\XB5772073
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\mapk8a
12 of 14
Yes
Yes
Drer\mapk8b
11 of 14
No
Yes
Drer\mapk9
10 of 14
No
Yes
Drer\mapk10
10 of 14
No
Yes
Drer\mapk1
2 of 14
No
No
Drer\mapk3
2 of 14
No
No
Drer\mapk7
2 of 14
No
No
Drer\mapk15
2 of 14
No
No
Drer\nlk1
2 of 14
No
No
Drer\nlk2
2 of 14
No
No
Drer\LOC100536197
1 of 14
No
No
Drer\mapk4
1 of 14
No
No
Drer\mapk6
1 of 14
No
No
Drer\mapk11
1 of 14
No
No
Drer\mapk12a
1 of 14
No
No
Drer\mapk12b
1 of 14
No
No
Drer\mapk13
1 of 14
No
No
Drer\mapk14a
1 of 14
No
No
Drer\mapk14b
1 of 14
No
No
Drer\pak2b
1 of 14
No
No
Drer\pak4
1 of 14
No
No
Drer\pak5
1 of 14
No
No
Drer\pak6b
1 of 14
No
No
Drer\pink1
1 of 14
No
No
Drer\zgc:171775
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (27)
Cele\jnk-1
13 of 14
Yes
Yes
Cele\kgb-1
4 of 14
No
Yes
Cele\kgb-2
4 of 14
No
Yes
Cele\Y51B9A.9
3 of 14
No
Yes
Cele\C49C3.10
2 of 14
No
Yes
Cele\F09C12.2
2 of 14
No
No
Cele\lit-1
2 of 14
No
No
Cele\mapk-15
2 of 14
No
No
Cele\mpk-1
2 of 14
No
No
Cele\mpk-2
2 of 14
No
No
Cele\pmk-3
2 of 14
No
No
Cele\sma-5
2 of 14
No
No
Cele\C16A11.10
1 of 14
No
No
Cele\cdk-12
1 of 14
No
No
Cele\hpk-1
1 of 14
No
No
Cele\K11H12.9
1 of 14
No
Yes
Cele\madd-3
1 of 14
No
No
Cele\mbk-1
1 of 14
No
No
Cele\mbk-2
1 of 14
No
No
Cele\pak-2
1 of 14
No
No
Cele\pink-1
1 of 14
No
No
Cele\pmk-1
1 of 14
No
No
Cele\pmk-2
1 of 14
No
No
Cele\prpf-4
1 of 14
No
No
Cele\strd-1
1 of 14
No
No
Cele\Y50D7A.3
1 of 14
No
No
Cele\Y111B2A.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (18)
Agam\AgaP_AGAP009461
6 of 12
Yes
Yes
Agam\AgaP_AGAP009460
4 of 12
No
Yes
Agam\AgaP_AGAP005898
2 of 12
No
No
Agam\AgaP_AGAP009207
2 of 12
No
No
Agam\AgaP_AGAP012148
2 of 12
No
No
Agam\AgaP_AGAP000847
1 of 12
No
No
Agam\AgaP_AGAP002119
1 of 12
No
No
Agam\AgaP_AGAP004315
1 of 12
No
No
Agam\AgaP_AGAP004443
1 of 12
No
No
Agam\AgaP_AGAP004579
1 of 12
No
No
Agam\AgaP_AGAP005772
1 of 12
No
No
Agam\AgaP_AGAP005851
1 of 12
No
No
Agam\AgaP_AGAP006411
1 of 12
No
No
Agam\AgaP_AGAP007342
1 of 12
No
No
Agam\AgaP_AGAP008241
1 of 12
No
No
Agam\AgaP_AGAP009936
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP013457
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (41)
Atha\ATMPK8
3 of 13
Yes
No
Atha\ATMPK13
3 of 13
Yes
No
Atha\MPK1
3 of 13
Yes
No
Atha\MPK2
3 of 13
Yes
No
Atha\MPK3
3 of 13
Yes
No
Atha\MPK4
3 of 13
Yes
No
Atha\MPK5
3 of 13
Yes
No
Atha\MPK6
3 of 13
Yes
No
Atha\MPK7
3 of 13
Yes
No
Atha\MPK9
3 of 13
Yes
No
Atha\MPK10
3 of 13
Yes
No
Atha\MPK11
3 of 13
Yes
No
Atha\MPK12
3 of 13
Yes
No
Atha\MPK14
3 of 13
Yes
No
Atha\MPK15
3 of 13
Yes
No
Atha\MPK16
3 of 13
Yes
No
Atha\MPK17
3 of 13
Yes
No
Atha\MPK18
3 of 13
Yes
No
Atha\MPK19
3 of 13
Yes
No
Atha\MPK20
3 of 13
Yes
No
Atha\AME3
1 of 13
No
No
Atha\AT1G03740
1 of 13
No
No
Atha\AT1G13350
1 of 13
No
No
Atha\AT1G33770
1 of 13
No
No
Atha\AT1G48490
1 of 13
No
No
Atha\AT1G54610
1 of 13
No
No
Atha\AT1G67580
1 of 13
No
No
Atha\AT1G71530
1 of 13
No
No
Atha\AT3G22750
1 of 13
No
No
Atha\AT3G25840
1 of 13
No
No
Atha\AT3G53640
1 of 13
No
No
Atha\AT3G61160
1 of 13
No
No
Atha\AT3G61960
1 of 13
No
No
Atha\AT4G10010
1 of 13
No
No
Atha\AT4G19110
1 of 13
No
No
Atha\AT5G44290
1 of 13
No
No
Atha\CDC2
1 of 13
No
No
Atha\FC1
1 of 13
No
No
Atha\FC2
1 of 13
No
No
Atha\MHK
1 of 13
No
No
Atha\YAK1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (16)
Scer\KDX1
2 of 13
Yes
No
Scer\SLT2
2 of 13
Yes
No
Scer\BCK1
1 of 13
No
No
Scer\CDC5
1 of 13
No
No
Scer\CDC28
1 of 13
No
No
Scer\FUS3
1 of 13
No
No
Scer\HOG1
1 of 13
No
No
Scer\KNS1
1 of 13
No
No
Scer\KSS1
1 of 13
No
No
Scer\MEK1
1 of 13
No
No
Scer\PHO85
1 of 13
No
No
Scer\PSK1
1 of 13
No
No
Scer\SGV1
1 of 13
No
No
Scer\SMK1
1 of 13
No
No
Scer\TPK3
1 of 13
No
No
Scer\YAK1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pmk1
1 of 12
Yes
No
Spom\ppk9
1 of 12
Yes
No
Spom\spk1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:bsk. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (21)
Erk7
4 of 13
nmo
4 of 13
p38a
4 of 13
p38b
4 of 13
p38c
4 of 13
rl
4 of 13
CG42366
3 of 13
CG8565
2 of 13
CaMKI
1 of 13
Cdk2
1 of 13
Doa
1 of 13
Dyrk2
1 of 13
Hipk
1 of 13
mbt
1 of 13
mnb
1 of 13
Pak
1 of 13
Pink1
1 of 13
S6k
1 of 13
sgg
1 of 13
Srpk79D
1 of 13
SRPK
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Evidence
    References
    bsk1
    model of  Parkinson's disease
    CEA
    (Inamdar et al., 2014)
    bsk2
    model of  Parkinson's disease
    CEA
    (Inamdar et al., 2014)
    bskDN.UAS
    model of  cancer
    CEA with DeltaUAS.cDa
    (Bossuyt et al., 2009)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 11 )
    Allele
    Disease
    Interaction
    References
    bskHMS00777
    ameliorates  colorectal cancer
    modeled by Ras85DV12.UAS
    (Bangi et al., 2012)
    ameliorates  lower respiratory tract disease
    modeled by PGRP-LCx.UAS
    (Wagner et al., 2021)
    ameliorates  cancer
    modeled by RafF22.hs
    (Zhao et al., 2021)
    bskJF01275
    ameliorates  hematologic cancer
    modeled by mxc1
    (Takarada et al., 2023)
    bsk1
    ameliorates  retinitis pigmentosa
    modeled by ninaEP37H, ninaE17
    (Griciuc et al., 2014)
    ameliorates  Alzheimer's disease
    modeled by Hsap\APPAβ42.UAS.cUa
    (Hong et al., 2012)
    ameliorates  human immunodeficiency virus infectious disease
    modeled by HIV-1\nefUAS.cLa
    (Lee et al., 2005)
    ameliorates  fragile X-associated tremor/ataxia syndrome
    modeled by Zzzz\CGG90.UAS.EGFP
    (Bhat et al., 2021)
    bskDN.UAS
    ameliorates  gastrointestinal adenoma
    modeled by ApcQ8, Apc2g10
    (Suijkerbuijk et al., 2016)
    ameliorates  cancer
    modeled by Ras85DV12.UAS, fmt1
    (Ma et al., 2017)
    modeled by Ras85DV12.UAS, PpVΔ1
    (Ma et al., 2017)
    modeled by l(2)glGD4047, RpL27A1
    (Grifoni et al., 2015)
    modeled by Ras85DV12.UAS
    (Waghmare et al., 2024)
    modeled by dor8, Ras85DV12.UAS
    (Chi et al., 2010)
    modeled by Ras85DV12.UAS, scrib1
    (Wu et al., 2010)
    modeled by Hsap\S100A4wt.UAS, Ras85DV12.UAS
    (Ismail et al., 2017)
    modeled by Ras85DV12.UAS, scrib673
    (Pérez et al., 2017)
    ameliorates  carcinoma
    modeled by EgfrUAS.cBa, Socs36EGD8929
    (Xu et al., 2022)
    modeled by Ras85DV12.UAS, l(2)gl4
    (Srivastava et al., 2007, Igaki et al., 2006)
    modeled by Ras85DV12.UAS, scrib1
    (Igaki et al., 2006, Uhlirova and Bohmann, 2006)
    modeled by Ras85DV12.UAS, dlg114
    (Igaki et al., 2006)
    modeled by Ras85DV12.UAS, egrUAS.cIa
    (Igaki et al., 2006)
    modeled by scribHMJ21977, ykiS111A.S168A.S250A.UAS.Tag:V5
    (Snigdha et al., 2021)
    exacerbates  cancer
    modeled by DeltaUAS.cDa, lolaGS88A8, psqGS88A8
    (Bossuyt et al., 2009)
    modeled by pnutGD1512, ykiUAS.cHa
    (Gerlach et al., 2018)
    ameliorates  neurodegenerative disease
    modeled by Hsap\APPAβ42.UAS.cUa
    (Tare et al., 2011)
    ameliorates  colorectal cancer
    modeled by Ras85DV12.UAS
    (Bangi et al., 2012)
    ameliorates  Alzheimer's disease 1
    modeled by Hsap\APPAβ42.UAS.cUa
    (Irwin et al., 2020)
    DOES NOT ameliorate  cancer
    modeled by HipkUAS.Tag:HA
    (Blaquiere et al., 2018)
    ameliorates  intestinal cancer
    modeled by Sox21a6
    (Zhai et al., 2015)
    ameliorates  tauopathy
    modeled by shot3, tauMR22
    (Voelzmann et al., 2016)
    ameliorates  juvenile polyposis syndrome
    modeled by shnKK101278
    (Zhou and Boutros, 2020)
    modeled by MedKK108412
    (Zhou and Boutros, 2020)
    ameliorates  nephrolithiasis
    modeled by Pvrλ.UASp.Tag:MYC
    (Xu et al., 2024)
    exacerbates  carcinoma
    modeled by scrib1
    (Zheng et al., 2023)
    bskK53R.UAS
    ameliorates  obesity
    modeled by Itprka1091, Itprug3
    (Subramanian et al., 2013)
    ameliorates  disease of cellular proliferation
    modeled by hidUAS.cUa, BacA\p35UAS.cHa
    (Rudrapatna et al., 2013)
    ameliorates  cancer
    modeled by okrKK107487
    (Dekanty et al., 2015)
    modeled by mei-41GD4258
    (Dekanty et al., 2015)
    modeled by dlg1HMS01954
    (Bunker et al., 2015)
    modeled by CskQ156Stop, Ras85DV12.UAS
    (Hirabayashi et al., 2013)
    modeled by RafF22.hs
    (Zhao et al., 2021)
    DOES NOT ameliorate  cancer
    modeled by biUAS.cPa
    (Shen et al., 2014)
    modeled by aPKCΔN.UAS
    (Bunker et al., 2015)
    exacerbates  carcinoma
    modeled by scrib1
    (Uhlirova et al., 2005, Brumby and Richardson, 2003)
    ameliorates  high grade glioma
    modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
    (Jarabo et al., 2021, Portela et al., 2019)
    ameliorates  nervous system disease
    modeled by unc-104P350, unc-104bris
    (Li et al., 2017)
    ameliorates  lower respiratory tract disease
    modeled by PGRP-LCx.UAS
    (Wagner et al., 2021)
    ameliorates  carcinoma
    modeled by salmUAS.cKa
    (Sun et al., 2020)
    bskUAS.cBa
    exacerbates  Parkinson's disease 1
    modeled by Hsap\SNCAA30P.UAS
    (Liu et al., 2022)
    exacerbates  human immunodeficiency virus infectious disease
    modeled by HIV-1\nefUAS.cLa
    (Lee et al., 2005)
    bskNIG.5680R
    ameliorates  human immunodeficiency virus infectious disease
    modeled by HIV-1\VpuUAS.cLa
    (Marchal et al., 2012)
    bskDN.UAS.cUa
    ameliorates  rhabdoid cancer
    modeled by Snr1HMS00363, BacA\p35UAS.cHa
    (Xie et al., 2017)
    ameliorates  cancer
    modeled by Bub3GD9924
    (Barrio et al., 2023)
    ameliorates  colorectal cancer
    modeled by UvragHMS01357
    (Nagy et al., 2016)
    ameliorates  carcinoma
    modeled by Mef2UAS.cUa, NICN.UAS
    (Pallavi et al., 2012)
    modeled by Ras85DV12.UAS, msn3208
    (Kong et al., 2021)
    modeled by ph-d505, ph-p505
    (Beira et al., 2018)
    modeled by NkapGD11807
    (Guo et al., 2024)
    exacerbates  carcinoma
    modeled by Vps25N55
    (Woodfield et al., 2013)
    modeled by scrib1
    (Kong et al., 2021)
    bskGD10555
    ameliorates  colorectal cancer
    modeled by SH3PX1JF02730
    (Zhang et al., 2019)
    exacerbates  Huntington's disease
    modeled by Hsap\HTTQ91.ex1.QUAS.mCherry
    (Pearce et al., 2015)
    bskHMC03539
    ameliorates  hematologic cancer
    modeled by mxc1
    (Takarada et al., 2023)
    bskHMS04479
    ameliorates  fragile X syndrome
    modeled by Fmr1Δ50M
    (Russo and DiAntonio, 2019)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MAPK8; mitogen-activated protein kinase 8
    12 of 14
    601158
         
        MAPK9; mitogen-activated protein kinase 9
        11 of 14
        602896
             
            MAPK10; mitogen-activated protein kinase 10
            11 of 14
            602897
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                bsk
                suppressible
                aop
                (Riesgo-Escovar and Hafen, 1997)
                bsk
                enhanceable
                Cka
                (Chen et al., 2002)
                mad2|bsk
                suppressible
                CycB
                (Wong et al., 2014)
                bsk|BubR1
                suppressible
                dap
                (Wong et al., 2014)
                mad2|bsk
                suppressible
                Dark
                (Wong et al., 2014)
                mad2|bsk
                suppressible
                Debcl
                (Wong et al., 2014)
                bsk
                enhanceable
                dsh
                (Srahna et al., 2006)
                bsk
                suppressible
                Fas2
                (Bornstein et al., 2015)
                mad2|bsk
                suppressible
                hid
                (Wong et al., 2014)
                bsk
                suppressible
                Hsp26
                (Rallis et al., 2013)
                bsk
                suppressible
                ics
                (Kadrmas et al., 2004)
                bsk
                suppressible
                Ilp2
                (Karpac et al., 2009)
                bsk
                enhanceable
                Jra
                (Rallis et al., 2010, Riesgo-Escovar and Hafen, 1997)
                bsk
                suppressible
                Jra
                (Hou et al., 1997)
                bsk
                enhanceable
                kay
                (Rallis et al., 2010)
                bsk
                enhanceable
                L
                (Singh et al., 2006)
                bsk
                suppressible
                Ldh
                (Liu et al., 2017)
                bsk
                suppressible
                Mnat9
                (Deshpande et al., 2023)
                scrib|bsk
                suppressible
                msn
                (Kong et al., 2021)
                bsk
                enhanceable
                msn
                (Su et al., 1998)
                mad2|bsk
                suppressible
                Myt1
                (Wong et al., 2014)
                bsk
                suppressible
                out
                (Liu et al., 2017)
                bsk
                suppressible
                park
                (Hwang et al., 2010)
                bsk
                enhanceable
                park
                (Cha et al., 2005)
                bsk
                suppressible
                Pdha1
                (Liu et al., 2017)
                bsk
                suppressible
                puc
                (Wang et al., 2003)
                bsk
                suppressible
                Sac1
                (Wei et al., 2003)
                bsk
                suppressible
                Sln
                (Liu et al., 2017)
                bsk
                suppressible
                spoon
                (Das et al., 2023)
                bsk
                enhanceable
                spoon
                (Das et al., 2023)
                bsk
                suppressible
                syd
                (Ahmad et al., 2021)
                egr|bsk
                enhanceable
                Tace
                (Chabu and Xu, 2014)
                bsk
                enhanceable
                Traf4
                (Cha et al., 2003)
                bsk
                suppressible
                whd
                (Tiwari et al., 2020)
                Ras85D|bsk|msn
                suppressible
                wts
                (Kong et al., 2021)
                bsk
                suppressible
                Xbp1
                (Wang et al., 2014)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Alg3
                suppressible
                bsk
                (de Vreede et al., 2018)
                Apc2|Apc
                suppressible
                bsk
                (Suijkerbuijk et al., 2016)
                arm
                suppressible
                bsk
                (Zhang et al., 2019, McEwen et al., 2000)
                Atg1
                suppressible
                bsk
                (Shen and Ganetzky, 2009)
                Atg9
                suppressible
                bsk
                (Tang et al., 2013)
                Axud1
                suppressible
                bsk
                (Glavic et al., 2009)
                brat
                enhanceable
                bsk
                (Hussain et al., 2017)
                brat
                suppressible
                bsk
                (Hussain et al., 2017)
                by
                enhanceable
                bsk
                (Lee et al., 2003)
                CG12744
                suppressible
                bsk
                (Wang et al., 2024)
                cindr
                enhanceable
                bsk
                (Ketosugbo et al., 2017)
                Cka
                suppressible
                bsk
                (La Marca et al., 2019)
                Cln3
                enhanceable
                bsk
                (Tuxworth et al., 2009)
                cno
                suppressible
                bsk
                (Boettner et al., 2003, Takahashi et al., 1998)
                Csk
                suppressible
                bsk
                (Rudrapatna et al., 2014, Read et al., 2004)
                CYLD
                suppressible
                bsk
                (Xue et al., 2007)
                Dad1
                suppressible
                bsk
                (Zhang et al., 2016)
                Daxx
                suppressible
                bsk
                (Hwang et al., 2013)
                Daxx
                enhanceable
                bsk
                (Hwang et al., 2013)
                Der-1
                suppressible
                bsk
                (Liu et al., 2022)
                dpp
                suppressible
                bsk
                (Yang and Su, 2011)
                Dref
                suppressible
                bsk
                (Yoshioka et al., 2012)
                dsh
                suppressible
                bsk
                (Paricio et al., 1999, Boutros et al., 1998, Strutt et al., 1997)
                dsh
                enhanceable
                bsk
                (Srahna et al., 2006)
                Eaat1
                suppressible
                bsk
                (Peng et al., 2019)
                ec
                suppressible
                bsk
                (Montrasio et al., 2007)
                egr
                suppressible
                bsk
                (Velentzas et al., 2018, Ren et al., 2017, Zhang et al., 2015, Ma et al., 2012, Mathew et al., 2011, Geuking et al., 2005, Igaki et al., 2002, Moreno et al., 2002)
                egr|CtBP
                suppressible
                bsk
                (Worley et al., 2018)
                Fas2
                enhanceable
                bsk
                (Bornstein et al., 2015)
                flw
                suppressible
                bsk
                (Kirchner et al., 2007)
                Fmr1
                suppressible
                bsk
                (Russo and DiAntonio, 2019)
                fmt
                suppressible
                bsk
                (Ma et al., 2017)
                foxo
                suppressible
                bsk
                (Wang et al., 2005)
                fz
                suppressible
                bsk
                (Strutt et al., 1997)
                fzy
                suppressible
                bsk
                (Kuang et al., 2014)
                Gli
                suppressible
                bsk
                (Padash-Barmchi et al., 2010)
                grnd
                suppressible
                bsk
                (Zheng et al., 2025)
                H
                suppressible
                bsk
                (Müller et al., 2005)
                hep
                suppressible
                bsk
                (Ren et al., 2017, Zhang et al., 2015, Mathew et al., 2011, Baril et al., 2009, Cha et al., 2005, Geuking et al., 2005)
                hid
                suppressible
                bsk
                (Rudrapatna et al., 2013)
                Hipk
                suppressible
                bsk|yki
                (Blaquiere et al., 2018)
                Hipk
                enhanceable
                bsk
                (Blaquiere et al., 2018)
                His1
                suppressible
                bsk
                (Bayona-Feliu et al., 2017)
                hiw
                suppressible
                bsk
                (Huang et al., 2012, Collins et al., 2006)
                hppy
                suppressible
                bsk
                (Lam et al., 2010)
                Ire1
                suppressible
                bsk
                (Yan et al., 2019)
                Itpr
                suppressible
                bsk
                (Subramanian et al., 2013)
                kay
                enhanceable
                bsk
                (Riesgo-Escovar and Hafen, 1997)
                kis
                suppressible
                bsk
                (Gervais et al., 2019)
                L
                enhanceable
                bsk
                (Singh et al., 2006)
                L
                suppressible
                bsk
                (Singh et al., 2006)
                lic
                suppressible
                bsk
                (Sun et al., 2019)
                lic
                enhanceable
                bsk
                (Sun et al., 2019)
                Lkb1
                enhanceable
                bsk
                (Lee et al., 2006)
                lncRNA:acal
                suppressible
                bsk
                (Ríos-Barrera et al., 2015)
                lola|psq|Delta
                enhanceable
                bsk
                (Bossuyt et al., 2009)
                MAPk-Ak2
                suppressible
                bsk
                (Seisenbacher et al., 2011)
                mei-41
                suppressible
                bsk
                (Dekanty et al., 2015)
                Mnat9
                suppressible
                bsk
                (Deshpande et al., 2023)
                Mnat9
                enhanceable
                bsk
                (Mok and Choi, 2021)
                msn
                suppressible
                bsk
                (Paricio et al., 1999)
                mxc
                suppressible
                bsk
                (Takarada et al., 2023)
                Myd88
                suppressible
                bsk
                (Foldi et al., 2017)
                N
                suppressible
                bsk
                (Langen et al., 2013)
                Nf-YA
                enhanceable
                bsk
                (Yoshioka et al., 2008)
                Nf-YA
                suppressible
                bsk
                (Yoshioka et al., 2008)
                ninaE
                suppressible
                bsk
                (Griciuc et al., 2014)
                Nkap
                suppressible
                bsk
                (Guo et al., 2024)
                nmo
                suppressible
                bsk
                (Fiehler and Wolff, 2008, Mirkovic et al., 2002)
                okr
                suppressible
                bsk
                (Dekanty et al., 2015)
                p53|mrn
                suppressible
                bsk
                (Villicaña et al., 2013)
                Paip1
                suppressible
                bsk
                (Xue et al., 2023)
                Pak
                suppressible
                bsk
                (Langen et al., 2013)
                park
                enhanceable
                bsk
                (Cha et al., 2005)
                park
                suppressible
                bsk
                (Cha et al., 2005)
                peb
                suppressible
                bsk
                (Pickup et al., 2002, Reed et al., 2001)
                Pi3K59F
                suppressible
                bsk
                (O'Farrell et al., 2017)
                Pi3K92E|btl::Egfr
                suppressible
                bsk
                (Portela et al., 2019)
                Pkn
                enhanceable
                bsk
                (Sass and Ostrow, 2014, Lu and Settleman, 1999)
                pnut
                suppressible
                bsk
                (Gerlach et al., 2018)
                prel
                enhanceable
                bsk
                (Tsuyama et al., 2017)
                Pten
                suppressible
                bsk
                (Nowak et al., 2013)
                puc
                suppressible
                bsk
                (Taniguchi et al., 2007, McEwen and Peifer, 2005, Wang et al., 2003, Sanyal et al., 2002)
                puc|flw
                suppressible
                bsk
                (Kirchner et al., 2007)
                Pvr
                enhanceable
                bsk
                (Mathieu et al., 2007, Ishimaru et al., 2004)
                PXo
                suppressible
                bsk
                (Xu et al., 2023)
                Rab11
                suppressible
                bsk
                (Tiwari and Roy, 2009)
                Rac1
                suppressible
                bsk
                (Baril et al., 2009, Srahna et al., 2006, Stronach and Perrimon, 2002, Fanto et al., 2000)
                Raf|scrib
                suppressible
                bsk|ZnT86D
                (Wei et al., 2021)
                Raf|scrib
                suppressible
                bsk
                (Wei et al., 2021)
                Rala
                suppressible
                bsk
                (Balakireva et al., 2006, Sawamoto et al., 1999)
                Ras85D
                suppressible
                bsk
                (Ismail et al., 2017, Bangi et al., 2012, Wu et al., 2009, Uhlirova and Bohmann, 2006)
                Ras85D|dor
                suppressible
                bsk
                (Chi et al., 2010)
                Ras85D|dlg1
                suppressible
                bsk
                (Katheder et al., 2017)
                Ras85D|PpV
                suppressible
                bsk
                (Ma et al., 2017)
                Ras85D|Ets21C
                suppressible
                bsk
                (Külshammer et al., 2015)
                Ras85D|msn
                suppressible
                bsk
                (Kong et al., 2021)
                Ras85D|fmt
                suppressible
                bsk
                (Ma et al., 2017)
                Ras85D|emei
                suppressible
                bsk
                (Ma et al., 2020)
                Ras85D|Stim|Orai
                suppressible
                bsk
                (Ma et al., 2020)
                Ras85D|scrib
                suppressible
                bsk
                (Katheder et al., 2017, Wu et al., 2010, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)
                Ras85D|Sec15
                suppressible
                bsk
                (Chabu and Xu, 2014)
                raw
                suppressible
                bsk
                (Jemc et al., 2012)
                Rbf
                suppressible
                bsk
                (Milet et al., 2014)
                Rer1
                suppressible
                bsk
                (Paul et al., 2024)
                Ret
                suppressible
                bsk
                (Read et al., 2005)
                Rho1
                suppressible
                bsk
                (Neisch et al., 2010)
                RpL27A|l(2)gl
                suppressible
                bsk
                (Grifoni et al., 2015)
                rpr
                suppressible
                bsk
                (Kuranaga et al., 2002)
                RpS3|yki
                suppressible
                bsk
                (Wada et al., 2021)
                Sarm
                suppressible
                bsk
                (Foldi et al., 2017)
                scrib
                suppressible
                bsk
                (Zheng et al., 2023, Zhang et al., 2019, Rives-Quinto et al., 2017, Uhlirova et al., 2005, Brumby and Richardson, 2003)
                scrib
                enhanceable
                bsk
                (Uhlirova et al., 2005)
                scrib|Xbp1
                suppressible
                bsk
                (Zheng et al., 2023)
                scrib|Ire1
                suppressible
                bsk
                (Zheng et al., 2023)
                scrib|Ire1
                suppressible
                Atg6|bsk
                (Zheng et al., 2023)
                scrib|Ire1
                suppressible
                bsk|Atg13
                (Zheng et al., 2023)
                sgg
                suppressible
                bsk
                (Franciscovich et al., 2008)
                SH3PX1
                suppressible
                bsk
                (Zhang et al., 2019)
                shot
                suppressible
                bsk
                (Valakh et al., 2013)
                Sin3A
                suppressible
                bsk
                (Das et al., 2013)
                Sin3A|Csk
                enhanceable
                bsk
                (Das et al., 2013)
                Sin3A|Csk
                suppressible
                bsk
                (Das et al., 2013)
                Sirt1
                suppressible
                bsk
                (Griswold et al., 2008)
                SkpA
                suppressible
                bsk
                (Brace et al., 2014)
                slpr
                enhanceable
                bsk
                (Polaski et al., 2006)
                Snr1
                suppressible
                bsk
                (Xie et al., 2017)
                Sox21a
                suppressible
                bsk
                (Zhai et al., 2015)
                spoon
                suppressible
                bsk
                (Das et al., 2023)
                Src42A
                enhanceable
                bsk
                (Tateno et al., 2000)
                Src64B
                suppressible
                bsk
                (Fernández et al., 2014)
                Strip
                suppressible
                bsk
                (La Marca et al., 2019)
                synr
                suppressible
                bsk
                (Sulekh et al., 2024)
                Syx7
                suppressible
                bsk
                (Andersen et al., 2015)
                Tace
                suppressible
                bsk
                (Muliyil et al., 2020)
                Tak1
                suppressible
                bsk
                (Yang and Su, 2011, Xue et al., 2007, Mihaly et al., 2001, Takatsu et al., 2000)
                TER94
                suppressible
                bsk
                (Liu et al., 2022)
                Tg
                suppressible
                bsk
                (Umehara et al., 2010)
                Toll-7
                suppressible
                bsk
                (Ding et al., 2022)
                Traf4
                enhanceable
                bsk
                (Cha et al., 2003)
                trc
                enhanceable
                bsk
                (He et al., 2005)
                unc-104
                suppressible
                bsk
                (Chen et al., 2012)
                Uvrag
                suppressible
                bsk
                (Nagy et al., 2016)
                Vha44
                suppressible
                bsk
                (Petzoldt et al., 2013)
                vito
                suppressible
                bsk
                (Marinho et al., 2011)
                Vps4
                suppressible
                bsk
                (Rodahl et al., 2009)
                vtd
                suppressible
                bsk
                (Liu et al., 2015)
                wgn
                suppressible
                bsk
                (Zheng et al., 2025)
                wnd
                suppressible
                bsk
                (Collins et al., 2006)
                wupA
                suppressible
                bsk
                (Casas-Tintó et al., 2016)
                Xbp1
                suppressible
                bsk
                (Wang et al., 2015, Wang et al., 2014)
                yki|pnut
                enhanceable
                bsk
                (Gerlach et al., 2018)
                ZnT86D
                suppressible
                bsk
                (Wei et al., 2021)
                α-Spec
                enhanceable
                bsk
                (Keller et al., 2011)
                External Data
                Subunit Structure (UniProtKB)
                Interacts with MKP-4 (via tyrosine-protein phosphatase domain); the interaction dephosphorylates bsk.
                (UniProt, P92208 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-40
                Cytogenetic map
                31B1-31B1
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                31B1-31B1
                Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                31B1-31B1
                (Riesgo-Escovar, 1996.10.3)
                31B-31C
                (determined by in situ hybridisation)
                (Sluss et al., 1996)
                31B-31B
                (determined by in situ hybridisation)
                (Riesgo-Escovar et al., 1996)
                Experimentally Determined Recombination Data
                Location

                2-40

                (FlyBase, 2016)

                2-34.8

                (Comeron et al., 2012)

                2-

                (Riesgo-Escovar, 1996.10.3)

                2-33

                (Tearle and Nusslein-Volhard, 1987)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (31)
                Genomic Clones (17)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (36)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    bsk is required for axon pruning of mushroom body gamma neurons, but not for pruning of their dendrites. It promotes mushroom body axon pruning by reducing the membrane levels of the Fas2 protein.

                    (Bornstein et al., 2015)

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)

                    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                    (Rogers et al., 2003)

                    The wg and bsk (JNK) signaling cascades collaborate to promote both dorsal closure and ventral patterning.

                    (McEwen et al., 2000)

                    bsk functions in the establishment of planar polarity in the eye.

                    (Weber et al., 2000)

                    Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues.

                    (Paricio et al., 1999)

                    msn acts through bsk in epithelial planar polarity (EPP) signalling.

                    (Paricio et al., 1999)

                    Genetic and over-expression assays show that dsh protein activates JNK cascades.

                    (Boutros et al., 1998)

                    Phylogenetic and functional relationships of MAPKs is studied based on 93 non-redundant full length sequences, 2 atomic structures and known functions of MAPKs.

                    (Kultz, 1998)

                    Leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.

                    (Glise and Noselli, 1997)

                    Jra in the embryo is a downstream target of the bsk signal transduction pathway during dorsal closure formation. The function of the bsk/Jra pathway is to control the localised expression of dpp. Both in the embryo and during photoreceptor cell determination Jra is not regulated by a pathway that involved rl.

                    (Hou et al., 1997)

                    The bsk pathway is functionally linked to the dpp pathway, the bsk pathway controls dorsal closure at least in part by regulating dpp expression in the leading edge cells. dpp expression is reduced or absent in leading edge cells of embryos lacking bsk function. Transcription factors Jra and aop are required for dorsal closure. Results suggest that the bsk pathway governs dorsal closure at least partially by regulating dpp expression via phosphorylation of Jra and aop.

                    (Riesgo-Escovar and Hafen, 1997)

                    bsk function is not required for cell fate specification in the eye.

                    (Riesgo-Escovar et al., 1996)

                    bsk mediates an immune response in cells in culture and morphogenesis in vivo.

                    (Sluss et al., 1996)

                    bsk embryos display relatively subtle defects in the nervous system, late in development. Brain and gut protrude from an unusually anterior dorsal hole.

                    (Cole et al., 1995)

                    Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS induced alleles of bsk.

                    (Goberdhan et al., 1995)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: bsk CG5680

                    (Bayraktaroglu, 2000.4.13)
                    Additional comments
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (41)
                    Reported As
                    Symbol Synonym
                    BSK
                    (Feng et al., 2022, Feng et al., 2018, Whon et al., 2017, Wang et al., 2012)
                    Basket
                    (Scepanovic et al., 2021)
                    Bsk
                    (Kodra et al., 2024, Meyer et al., 2024, Nigg et al., 2024, Shweta et al., 2024, Chen et al., 2023, Kietz and Meinander, 2023, Li et al., 2023, Pai et al., 2023, Sriskanthadevan-Pirahas et al., 2023, Williams et al., 2023, Boulanger and Dura, 2022, Chen et al., 2022, Ding et al., 2022, Logeay et al., 2022, Nefedova et al., 2022, Yu et al., 2022, Ahmad et al., 2021, Chen et al., 2021, Cong et al., 2021, Costa-Rodrigues et al., 2021, Dillard et al., 2021, Dong et al., 2021, Gan et al., 2021, Harnish et al., 2021, Herrera and Bach, 2021, Millet-Boureima et al., 2021, Mishra et al., 2021, Sharma et al., 2021, Sheng et al., 2021, Wu et al., 2021, Fujisawa et al., 2020, La Marca and Richardson, 2020, Morris et al., 2020, Perez-Gomez et al., 2020, Rodriguez-Fernandez et al., 2020, Tang et al., 2020, Zhou and Boutros, 2020, Li et al., 2019, Luo et al., 2019, Yan et al., 2019, Zhang et al., 2019, Cong et al., 2018, Pinal et al., 2018, Wang et al., 2018, Houtz et al., 2017, Liao et al., 2017, Muzzopappa et al., 2017, Resnik-Docampo et al., 2017, Richardson and Portela, 2017, Song et al., 2017, Wang et al., 2017, Zheng et al., 2017, Zhou et al., 2017, Aggarwal et al., 2016, Atkins et al., 2016, Bhadra et al., 2016, Padash Barmchi et al., 2016, Schimizzi et al., 2016, Sharifkhodaei et al., 2016, Toggweiler et al., 2016, Casas-Tintó et al., 2015, Enomoto et al., 2015, Meng and Biteau, 2015, Siudeja et al., 2015, Wu et al., 2015, Zhang et al., 2015, Griciuc et al., 2014, Huang et al., 2014, Poulton et al., 2014, Wang et al., 2014, Dantoft et al., 2013, Karpac et al., 2013, Klinedinst et al., 2013, Ma et al., 2013, Petzoldt et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Subramanian et al., 2013, Tang et al., 2013, Wong et al., 2013, Zhang et al., 2013, Baek et al., 2012, Bangi et al., 2012, Bier and Guichard, 2012, Chen et al., 2012, Huang et al., 2012, Kapfhamer et al., 2012, Stevens and Page-McCaw, 2012, Bangi et al., 2011, Biteau et al., 2011, Karpac et al., 2011, Richter et al., 2011, Biteau et al., 2010, Oliva and Sierralta, 2010, Singh et al., 2010, Wang et al., 2010, Wu et al., 2010, Geuking et al., 2009, Glavic et al., 2009, Jiang et al., 2009, Liu et al., 2009, Rodahl et al., 2009, Tuxworth et al., 2009, Ayaz et al., 2008, Bond et al., 2008, Franciscovich et al., 2008, Liebl and Featherstone, 2008, Igaki et al., 2006, Williams et al., 2006, Mattila et al., 2005)
                    CG5680
                    (National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Gruntenko et al., 2021, Caizzi et al., 2016, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Bossuyt et al., 2009, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2008, Rogers et al., 2003, Morrison et al., 2000)
                    D-JNK
                    (Ryabinina et al., 2006, Lorenzen et al., 2003, Han et al., 1998)
                    D-junk
                    (Riesgo-Escovar et al., 1995)
                    DBSK/JNK
                    (Chen et al., 2002)
                    DJNK
                    (Sekine et al., 2012, Vadász et al., 2012, Chung et al., 2010, Sun et al., 2008, Miotto et al., 2006, Scuderi and Letsou, 2005, Jindra et al., 2004, Varfolomeev and Ashkenazi, 2004, Ballew et al., 2003, Kurz and Ewbank, 2003, Yang et al., 2003, Goberdhan and Wilson, 2002, Hudson and Cooley, 2002, Kim et al., 2002, Manfruelli et al., 2002, Taru et al., 2002, Van Aelst and Symons, 2002, Botella et al., 2001, Manfruelli et al., 2001, Lee et al., 2000, Weitzman, 2000, Adachi-Yamada et al., 1999, Goberdhan et al., 1999, Fields and Montell, 1998, Goberdhan and Wilson, 1998, Ip and Davis, 1998, Buckingham and Dexter, 1997, Goberdhan et al., 1997, Minden and Karin, 1997, Riesgo-Escovar and Hafen, 1997, Sluss and Davis, 1997, Van Aelst and D'Souza-Schorey, 1997, Wilson et al., 1997, Davis, 1996.2.13, Davis, 1996.2.15, Davis, 1996.3.8, Davis, 1996.3.8, Riesgo-Escovar et al., 1996, Sluss et al., 1996)
                    DJNK/bsk
                    (Otto et al., 2000)
                    DmJNK
                    (Xiao et al., 2017)
                    JAK
                    (Nayak and Mishra, 2022, Yasugi and Sato, 2022, Lan et al., 2020)
                    JNK
                    (Kumar and Srikrishna, 2025, Qin et al., 2025, Luo et al., 2024, Deng et al., 2023, Fangninou et al., 2023, Wang et al., 2023, Baonza et al., 2022, Baumgartner et al., 2022, Ciesielski et al., 2022, Crucianelli et al., 2022, Eickelberg et al., 2022, Enomoto and Igaki, 2022, Ji et al., 2022, Worley and Hariharan, 2022, Xiao, 2022, Bailey et al., 2021, Boumard and Bardin, 2021, Buhlman et al., 2021, Gong et al., 2021, Kunar and Roy, 2021, Li and Hidalgo, 2021, Marques-Reis and Moreno, 2021, Morata, 2021, Nishida et al., 2021, Paraskevopoulos and McGuigan, 2021, Sinenko et al., 2021, Snigdha et al., 2021, Wang et al., 2021, Yamazoe et al., 2021, Yi et al., 2021, Al Outa et al., 2020, Arora and Ligoxygakis, 2020, Baker, 2020, Chen et al., 2020, Cui et al., 2020, Fox et al., 2020, Gerlach and Herranz, 2020, Gogia et al., 2020, Gutiérrez-Martínez et al., 2020, Jasper, 2020, Li et al., 2020, Macedo et al., 2020, Manière et al., 2020, Morata and Calleja, 2020, Ngo et al., 2020, Rui et al., 2020, Tang et al., 2020, Vizcaya-Molina et al., 2020, von Frieling et al., 2020, Aryal and Lee, 2019, Galenza and Foley, 2019, Gupta et al., 2019, Hao et al., 2019, Hu and Jasper, 2019, Hwang et al., 2019, Katsube et al., 2019, Khatoon et al., 2019, Lee et al., 2019, Maitra et al., 2019, Russo and DiAntonio, 2019, Toshniwal et al., 2019, Wu et al., 2019, Ahmed-de-Prado and Baonza, 2018, Das et al., 2018, de Vreede et al., 2018, Diwanji and Bergmann, 2018, Dutta et al., 2018, Feng et al., 2018, Khan et al., 2018, Searle and Pillus, 2018, Su et al., 2018, Takeda et al., 2018, Wang et al., 2018, Yang et al., 2018, Brace and DiAntonio, 2017, Fei et al., 2017, Hussain et al., 2017, Ismail et al., 2017, Khan et al., 2017, Lu et al., 2017, Pérez et al., 2017, Romani et al., 2017, Zhang et al., 2017, Aggarwal et al., 2016, Alfa and Kim, 2016, Batista et al., 2016, Chen et al., 2016, Feoktistov and Herman, 2016, Kaynar et al., 2016, Khoshnood et al., 2016, Saadin and Starz-Gaiano, 2016, Suijkerbuijk et al., 2016, Yadav and Tapadia, 2016, Yadav et al., 2016, Grifoni et al., 2015, Jasper, 2015, Kopp et al., 2015, Lashmanova et al., 2015, Neyen and Lemaitre, 2015, Santabárbara-Ruiz et al., 2015, Seeds et al., 2015, Shaukat et al., 2015, Su, 2015, Wang et al., 2015, Zhan et al., 2015, Zimmermann et al., 2015, Ballard et al., 2014, Cordero et al., 2014, Griciuc et al., 2014, Li et al., 2014, Thomas and Strutt, 2014, Zemolin et al., 2014, Dekanty and Milán, 2013, Ferrandon, 2013, Hada et al., 2013, Hwang et al., 2013, Langen et al., 2013, Pastor-Pareja and Xu, 2013, Petzoldt et al., 2013, Pronovost et al., 2013, Schoborg et al., 2013, Tang et al., 2013, Tian et al., 2013, Woodfield et al., 2013, Amoyel and Bach, 2012, Bond and Foley, 2012, Gistelinck et al., 2012, Gonda et al., 2012, Gowda et al., 2012, Kanao et al., 2012, Kang et al., 2012, Miura, 2012, Nam et al., 2012, Pallavi et al., 2012, Shlevkov and Morata, 2012, Spedale et al., 2012, Stevens and Page-McCaw, 2012, Vandenabeele and Bertrand, 2012, Wang et al., 2012, Bangi et al., 2011, Keller et al., 2011, Milton et al., 2011, Morata et al., 2011, Ohsawa et al., 2011, Sekine et al., 2011, Tower, 2011, Wang and Jin, 2011, Abu-Dayyeh et al., 2010, Ashton-Beaucage et al., 2010, Benitez et al., 2010, Bhuin and Roy, 2010, Buchon et al., 2010, Chen et al., 2010, Cordero et al., 2010, Falzone et al., 2010, Froldi et al., 2010, Gettings et al., 2010, Haghayeghi et al., 2010, Kim et al., 2010, Lee et al., 2010, Lee et al., 2010, Neisch et al., 2010, Radyuk et al., 2010, Rallis et al., 2010, Suganuma et al., 2010, Tamori et al., 2010, Warner et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Apidianakis et al., 2009, Baril et al., 2009, Bossuyt et al., 2009, Diangelo et al., 2009, Glavic et al., 2009, Guntermann et al., 2009, Hong et al., 2009, Lee et al., 2009, List et al., 2009, Liu et al., 2009, Rodahl et al., 2009, Tuxworth et al., 2009, Umemori et al., 2009, Williams, 2009, Wu et al., 2009, Wu et al., 2009, Bakal et al., 2008, Berger et al., 2008, Cui et al., 2008, Domingues and Ryoo, 2008, Franciscovich et al., 2008, Grima et al., 2008, Halme et al., 2008, Jimenez-Del-Rio et al., 2008, Jones et al., 2008, Lee et al., 2008, Lee et al., 2008, Llense and Martín-Blanco, 2008, McNamee and Brodsky, 2008, Melani et al., 2008, Sage et al., 2008, Wu et al., 2008, Balakireva et al., 2007, Bidla et al., 2007, Cinnamon et al., 2007, Fernández et al., 2007, Horiuchi et al., 2007, Kirchner et al., 2007, Kronhamn et al., 2007, Lecuit and Le Goff, 2007, Liu et al., 2007, Sackton et al., 2007, Sage et al., 2007, Waterhouse et al., 2007, Biswas et al., 2006, Bjorklund et al., 2006, Bovolenta et al., 2006, Delaney et al., 2006, Dionne et al., 2006, Herz et al., 2006, Homsy et al., 2006, Jordan et al., 2006, Lee et al., 2006, Luo et al., 2006, Maurange et al., 2006, Singh and Choi, 2006, Vidal et al., 2006, Anonymous, 2005, Bosch et al., 2005, Etter et al., 2005, Igaki et al., 2005, Ip, 2005, Kuttenkeuler et al., 2005, Mace et al., 2005, Mattila et al., 2005, Mehlen et al., 2005, Meller et al., 2005, Müller et al., 2005, Wech and Nagel, 2005, Brennan and Anderson, 2004, Chen et al., 2004, Donaldson and Duronio, 2004, Hay et al., 2004, Ishimaru et al., 2004, Kadrmas et al., 2004, McClure and Schubiger, 2004, Miotto et al., 2004, Park et al., 2004, Pilcher, 2004, Secombe et al., 2004, Udomsinprasert et al., 2004, Wells and Johnston, 2004, Yeo and Gautier, 2004, Hay and Guo, 2003, Hoffmann, 2003, Lee et al., 2003, Parkhurst and Delidakis, 2003, Sathyanarayana et al., 2003, Seyedoleslami Esfahani et al., 2003, Solnica-Krezel and Eaton, 2003, Wang et al., 2003, Adachi-Yamada and O'Connor, 2002, Aigaki et al., 2002, Galis et al., 2002, Jasper and Bohmann, 2002, Kuranaga et al., 2002, Liu and Moffat, 2002, Mlodzik, 2002, Muller et al., 2002, Noselli, 2002, Pandur et al., 2002, Ramet et al., 2002, Sathyanarayana et al., 2002, Tree et al., 2002, Verheyen et al., 2002, Wedlich, 2002, Ciapponi et al., 2001, Kockel et al., 2001, Muller and Littlewood-Evans, 2001, Pastor-Pareja et al., 2001, Pastor-Pareja et al., 2001, Reed et al., 2001, Settleman, 2001, Tootle and Rebay, 2001, Behrens, 2000, Fashena and Thomas, 2000, McEwen and Peifer, 2000, Morrison et al., 2000, Seidensticker and Behrens, 2000, Sokol, 2000, Blair, 1999, Mlodzik, 1999, Novak and Dedhar, 1999, Perrimon and Stern, 1999, Spana and Perrimon, 1999, Stronach and Perrimon, 1999, Yeaman et al., 1999, Boutros et al., 1998, Feiguin et al., 1998, Hall, 1998, Martin-Blanco et al., 1998, Anonymous, 1997, Hou et al., 1997, Jarvis and Schaefer, 1997, Kockel et al., 1997, Strutt et al., 1997, Harden et al., 1996)
                    JNK/SAPK
                    (Boutros and Mlodzik, 1999)
                    Jak
                    (Jia et al., 2022)
                    Jnk
                    (Sulekh et al., 2024, Zhang and Edgar, 2022, Choi et al., 2021, Morris and Jasper, 2021, Pandey et al., 2018, Stuelten et al., 2018, Levinson and Cagan, 2016, Jevtov et al., 2015, Das et al., 2013, Nechipurenko and Broihier, 2012, Parrott et al., 2011, Kim et al., 2005)
                    Junk
                    P-JNK
                    (Hebbar et al., 2015)
                    SAPK/JNK
                    (Murari et al., 2022, Qin et al., 2020)
                    SAPKa
                    (Kultz, 1998)
                    basket
                    (Lam Wong and Verheyen, 2021, Chimnaronk et al., 2015, Ojelade et al., 2015)
                    bsk
                    (Luo et al., 2025, Sheng et al., 2025, Zheng et al., 2025, Ahmed-de-Prado et al., 2024, Balakireva et al., 2024, Datta and Bangi, 2024, Gera et al., 2024, Hersperger et al., 2024, Huang et al., 2024, Ju et al., 2024, Kinoshita et al., 2024, Kosakamoto et al., 2024, Meng et al., 2024, Paul et al., 2024, Soares et al., 2024, Wang et al., 2024, Wang et al., 2024, Aromolaran et al., 2023, Barrio et al., 2023, Chen et al., 2023, Chimata et al., 2023, Das et al., 2023, Ji et al., 2023, Karkali et al., 2023, Khan et al., 2023, Loudhaief et al., 2023, Meng et al., 2023, Prasad et al., 2023, Sahana et al., 2023, Song et al., 2023, Takarada et al., 2023, Xue et al., 2023, Xu et al., 2023, Yamada et al., 2023, Yan et al., 2023, Yeates et al., 2023, Zheng et al., 2023, Benoit et al., 2022, Congleton et al., 2022, Evans et al., 2022, Gera et al., 2022, Gracia-Latorre et al., 2022, Havula et al., 2022, Kong et al., 2022, Lepeta et al., 2022, Yang et al., 2022, Zhou et al., 2022, Bhat et al., 2021, Fabian et al., 2021, Hsu et al., 2021, Joy et al., 2021, Klemm et al., 2021, Kong et al., 2021, Lebo and McCall, 2021, Lebo et al., 2021, Medina et al., 2021, Mesquita et al., 2021, Mok and Choi, 2021, Snigdha et al., 2021, Tavares et al., 2021, Wada et al., 2021, Wagner et al., 2021, Wang et al., 2021, Yoo et al., 2021, Zhao et al., 2021, Arnés et al., 2020, Banreti and Meier, 2020, Dai et al., 2020, Irwin et al., 2020, Jeon et al., 2020, Kanda and Igaki, 2020, Kwon et al., 2020, Li et al., 2020, Ma et al., 2020, Ma et al., 2020, Muliyil et al., 2020, Nandy and Roy, 2020, Ngo et al., 2020, Sun et al., 2020, Sun et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Wang et al., 2020, Zhao et al., 2020, Banerjee et al., 2019, Binh et al., 2019, Boulan et al., 2019, Brantley and Fuller, 2019, Cai et al., 2019, Camilleri-Robles et al., 2019, Chai et al., 2019, Chang et al., 2019, Coelho and Moreno, 2019, Dutta et al., 2019, Gervais et al., 2019, Hall et al., 2019, Herrera and Bach, 2019, Jiang et al., 2019, Khan et al., 2019, Khezri and Rusten, 2019, La Marca et al., 2019, Lambrechts et al., 2019, Lee et al., 2019, Li et al., 2019, Luo et al., 2019, Ma et al., 2019, Maier et al., 2019, Meltzer et al., 2019, Mishra-Gorur et al., 2019, Nakano et al., 2019, Ng, 2019.8.30, Park et al., 2019, Peng et al., 2019, Sanchez et al., 2019, Schaub et al., 2019, Sênos Demarco and Jones, 2019, Singh et al., 2019, Snigdha et al., 2019, Sun et al., 2019, Sun et al., 2019, Toshniwal et al., 2019, Wang et al., 2019, Wang et al., 2019, Wu et al., 2019, Xu et al., 2019, Yan et al., 2019, Yang et al., 2019, Zhang et al., 2019, Zhu et al., 2019, Behrman et al., 2018, Beira et al., 2018, Bushnell et al., 2018, Chi et al., 2018, Donohoe et al., 2018, Dutta et al., 2018, Gene Disruption Project members, 2018-, Hao et al., 2018, Koon et al., 2018, Kumar and Tiwari, 2018, Li et al., 2018, Mondal et al., 2018, Muñoz-Soriano et al., 2018, Paul et al., 2018, Poon et al., 2018, Resende et al., 2018, Tsai et al., 2018, Velentzas et al., 2018, Wang et al., 2018, Yang et al., 2018, Yu et al., 2018, Aggarwal et al., 2017, Akbergenova and Littleton, 2017, Borgen et al., 2017, Casas-Tintó et al., 2017, Chabu et al., 2017, He et al., 2017, Jo and Imm, 2017, Jordán-Álvarez et al., 2017, Katheder et al., 2017, Kenmoku et al., 2017, Lee et al., 2017, Li et al., 2017, Ma et al., 2017, Ma et al., 2017, Ma et al., 2017, Manent et al., 2017, Nazario-Yepiz and Riesgo-Escovar, 2017, O'Farrell et al., 2017, Pérez et al., 2017, Poulton et al., 2017, Rojas-Benítez et al., 2017, Tang et al., 2017, Taylor et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Tue et al., 2017, Xie et al., 2017, Zheng et al., 2017, Casas-Tintó et al., 2016, Chen et al., 2016, Hou et al., 2016, Huang et al., 2016, Ko et al., 2016, Levinson and Cagan, 2016, Ma et al., 2016, Rao et al., 2016, Tare et al., 2016, Toggweiler et al., 2016, Voelzmann et al., 2016, Weavers et al., 2016, Willsey et al., 2016, Yasin et al., 2016, Yoo et al., 2016, Zhang et al., 2016, Zhang et al., 2016, Zhang et al., 2016, Bornstein et al., 2015, Chen et al., 2015, Doggett et al., 2015, Grotewiel and Bettinger, 2015, Külshammer et al., 2015, Liu et al., 2015, Meserve and Duronio, 2015, Moreno et al., 2015, Patel et al., 2015, Pearce et al., 2015, Ríos-Barrera et al., 2015, Sansone et al., 2015, Vinatier et al., 2015, Wang et al., 2015, Wong et al., 2015, Woodcock et al., 2015, Xia et al., 2015, Zeidler, 2015.2.13, Zhai et al., 2015, Zhan et al., 2015, Zhang et al., 2015, Bischof and FlyORF project members, 2014.6.20, Brace et al., 2014, Chabu and Xu, 2014, Fernández et al., 2014, Gao et al., 2014, Gersten et al., 2014, Inamdar et al., 2014, Kuang et al., 2014, Macagno et al., 2014, Milet et al., 2014, Morishita et al., 2014, Okumura et al., 2014, Pereira et al., 2014, Radermacher et al., 2014, Rauskolb et al., 2014, Rudrapatna et al., 2014, Sass and Ostrow, 2014, Schulman et al., 2014, Shen et al., 2014, Soares et al., 2014, Sopko et al., 2014, Stone et al., 2014, Wang et al., 2014, Wong et al., 2014, Yanai et al., 2014, Burra et al., 2013, Carter, 2013, Das et al., 2013, Hirabayashi et al., 2013, Humphreys et al., 2013, Hwang et al., 2013, Külshammer and Uhlirova, 2013, Langen et al., 2013, Nowak et al., 2013, Owusu-Ansah et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Rudrapatna et al., 2013, Sun and Irvine, 2013, Telonis-Scott et al., 2013, Tian et al., 2013, Valakh et al., 2013, Villicaña et al., 2013, Woodfield et al., 2013, Yang et al., 2013, Ahn et al., 2012, Brock et al., 2012, Etchegaray et al., 2012, Förster and Luschnig, 2012, Gonda et al., 2012, Graves et al., 2012, Hong et al., 2012, Huang et al., 2012, Inamdar et al., 2012, Jemc et al., 2012, Kanao et al., 2012, Kapfhamer et al., 2012, Lu et al., 2012, Ma et al., 2012, Marchal et al., 2012, Pezzulo et al., 2012, Senthilan et al., 2012, Stern et al., 2012, Tsuzuki et al., 2012, Vadász et al., 2012, Yoshioka et al., 2012, Boyd et al., 2011, Brumby et al., 2011, Friedman et al., 2011, Huang et al., 2011, Kanda et al., 2011, Keller et al., 2011, Kuranaga et al., 2011, Maher et al., 2011, Marinho et al., 2011, Mathew et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Seisenbacher et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Tripura et al., 2011, Wertheim et al., 2011, Yang and Su, 2011, Zhao et al., 2011, Baek et al., 2010, Beam and Moberg, 2010, Bergantiños et al., 2010, Bhuin and Roy, 2010, Chen et al., 2010, Chi et al., 2010, Djiane and Mlodzik, 2010, Froldi et al., 2010, Garlena et al., 2010, Gettings et al., 2010, Grzeschik et al., 2010, Hwang et al., 2010, Kim et al., 2010, Kim et al., 2010, Kwon et al., 2010, Lam et al., 2010, Lennox and Stronach, 2010, Neisch et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Radyuk et al., 2010, Rallis et al., 2010, Shen et al., 2010, Sun et al., 2010, Umehara et al., 2010, Wu et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Zhang et al., 2010, Baril et al., 2009, Bossuyt et al., 2009, Chang and Neufeld, 2009, Chang and Neufeld, 2009, Hull-Thompson et al., 2009, Igaki et al., 2009, Karpac et al., 2009, Lee et al., 2009, Leong et al., 2009, Maezawa et al., 2009, Massaro et al., 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Shen and Ganetzky, 2009, Solon et al., 2009, Tiwari and Roy, 2009, Tuxworth et al., 2009, Weake et al., 2009, Widmann and Dahmann, 2009, Wu et al., 2009, Wu et al., 2009, Wu et al., 2009, Babcock et al., 2008, Bates et al., 2008, Biteau et al., 2008, Caussinus et al., 2008, Davis et al., 2008, Fiehler and Wolff, 2008, Franciscovich et al., 2008, Grima et al., 2008, Griswold et al., 2008, Jones et al., 2008, Llense and Martín-Blanco, 2008, Owusu-Ansah et al., 2008, Shimizu et al., 2008, Uthaman et al., 2008, Yoshioka et al., 2008, Abraham et al., 2007, Bidla et al., 2007, Curtis et al., 2007, Horiuchi et al., 2007, Junion et al., 2007, Kirchner et al., 2007, Lee et al., 2007, Mathieu et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Neuman-Silberberg, 2007, Peralta et al., 2007, Pfleger et al., 2007, Srivastava et al., 2007, Tyler et al., 2007, Valanne et al., 2007, Wada et al., 2007, Walther and Pichaud, 2007, Williams et al., 2007, Xue et al., 2007, Balakireva et al., 2006, Cerrato et al., 2006, Christensen and Cook, 2006.8.30, Guichard et al., 2006, Homsy et al., 2006, Igaki et al., 2006, Janody and Treisman, 2006, Lee et al., 2006, Polaski et al., 2006, Sato et al., 2006, Singh et al., 2006, Srahna et al., 2006, Uhlirova and Bohmann, 2006, He et al., 2005, Kim et al., 2005, Lee et al., 2005, Mace et al., 2005, Mace et al., 2005, McEwen and Peifer, 2005, Scuderi and Letsou, 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Fanto and McNeill, 2004, Kadrmas et al., 2004, Sawamura and Yamamoto, 2004, Stanyon et al., 2004, Cha et al., 2003, Harvey et al., 2003, Jenny et al., 2003, Pantalacci, 2003, Pantalacci et al., 2003, Mihaly et al., 2001)
                    bsk/JNK
                    (Funk et al., 2020)
                    dJNK
                    (Yasin et al., 2016, Tipping and Perrimon, 2014, Macdonald et al., 2013, Gowda et al., 2012, Bond and Foley, 2009, Mattila et al., 2008, Sano et al., 2005, Kuranaga et al., 2002, Kulansky Poltilove et al., 2000)
                    dJnk
                    (Hwang and Pallas, 2014)
                    dNJNK
                    (Freeman, 2015)
                    jnk
                    (Xie et al., 2021, Krautz et al., 2020, Srivastav et al., 2018, Ashton-Beaucage et al., 2016, Losick et al., 2016, Lauwers et al., 2009, Sage et al., 2006, Uhlirova and Bohmann, 2006, Leptin, 2005, Wang et al., 2005, Zhou et al., 2005)
                    jnk (bsk)
                    (Li et al., 2017)
                    p-JNK
                    (Yu et al., 2021, Zhang et al., 2017)
                    pJNK
                    (Parra and Johnston, 2020, Sun et al., 2020, Wong et al., 2020, Foldi et al., 2017, Bornstein et al., 2015, Tare et al., 2011)
                    Name Synonyms
                    Basket
                    (Krejčová et al., 2024, Layalle et al., 2021, Sharma et al., 2021, Feng et al., 2018, Atkins et al., 2016, Grill et al., 2016, Nagy et al., 2016, Andersen et al., 2015, Castillo et al., 2015, Poulton et al., 2014, Wang et al., 2014, Ayyaz and Jasper, 2013, Tang et al., 2013, Chen et al., 2012, Igboin et al., 2012, Pallavi et al., 2012, Katsuyama and Paro, 2011, Mathew et al., 2011, Razzell et al., 2011, Neisch et al., 2010, Oliva and Sierralta, 2010, Portela et al., 2010, Radyuk et al., 2010, Rallis et al., 2010, Bossuyt et al., 2009, Glavic et al., 2009, Hull-Thompson et al., 2009, Ohayon et al., 2009, Bond et al., 2008, Jones et al., 2008, Llense and Martín-Blanco, 2008, Orr et al., 2008, Shimizu et al., 2008, Horiuchi et al., 2007, Williams and Hultmark, 2007, Williams et al., 2006, Kim et al., 2005, Rogers et al., 2003)
                    JNK
                    (Collins et al., 2006)
                    JUN kinase
                    (Kim et al., 2010)
                    Jun N-terminal Kinase
                    (Froldi et al., 2010, Fernández et al., 2007, Mattila et al., 2005)
                    Jun N-terminal kinase
                    (Brace and DiAntonio, 2017, Amoyel and Bach, 2014, Bossuyt et al., 2009, Wu et al., 2008, Bidla et al., 2007, Lecuit and Le Goff, 2007, Taniguchi et al., 2007, Baehrecke, 2006, Maurange et al., 2006, Williams et al., 2006)
                    Jun NH2-terminal Kinase
                    (Glavic et al., 2009)
                    Jun kinase
                    (Spedale et al., 2012, Ming et al., 2008, Li and Baker, 2007, Humbert et al., 2003, Lecuit, 2003)
                    Jun-N Terminal kinase
                    (Santabárbara-Ruiz et al., 2015)
                    Jun-N-terminal Kinase
                    (Halme et al., 2008)
                    Jun-N-terminal kinase
                    (Alfa and Kim, 2016)
                    Jun-kinase
                    (Parrott et al., 2011, Parkhurst and Delidakis, 2003)
                    basket
                    (Krejčová et al., 2024, Sun et al., 2020, von Frieling et al., 2020, Brantley and Fuller, 2019, Weavers et al., 2019, Paul et al., 2018, Bayona-Feliu et al., 2017, Lu et al., 2017, Tomita et al., 2017, Yamaguchi et al., 2017, Nässel and Vanden Broeck, 2016, Wieschaus and Nüsslein-Volhard, 2016, Freeman, 2015, Ojelade et al., 2015, Zhai et al., 2015, Zhan et al., 2015, Gao et al., 2014, Kuang et al., 2014, Morishita et al., 2014, Pereira et al., 2014, Rudrapatna et al., 2014, Sass and Ostrow, 2014, Singh et al., 2014, Soares et al., 2014, Freeman et al., 2013, Hombría and Serras, 2013, Humphreys et al., 2013, Karpac et al., 2013, Ortega-Arellano et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Woodfield et al., 2013, Etchegaray et al., 2012, Inamdar et al., 2012, Jemc et al., 2012, Kang et al., 2012, Kapfhamer et al., 2012, Vadász et al., 2012, Boyd et al., 2011, Kraut, 2011, Muñoz-Soriano and Paricio, 2011, Sinenko et al., 2011, Sinenko et al., 2011, Bergantiños et al., 2010, Froldi et al., 2010, Gettings et al., 2010, Hwang et al., 2010, Lennox and Stronach, 2010, Yavari et al., 2010, Zhao et al., 2010, Buchon et al., 2009, Corl et al., 2009, Leong et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shen and Ganetzky, 2009, Weake et al., 2009, Babcock et al., 2008, Berger et al., 2008, Fiehler and Wolff, 2008, Grima et al., 2008, Melani et al., 2008, Wu et al., 2008, Yoshioka et al., 2008, Bidla et al., 2007, Halme and Hariharan, 2007, Montrasio et al., 2007, Neuman-Silberberg, 2007, Peralta et al., 2007, Pfleger et al., 2007, Sackton et al., 2007, Walther and Pichaud, 2007, Williams et al., 2007, Cerrato et al., 2006, Hashimoto and Yamaguchi, 2006, Herz et al., 2006, Homsy et al., 2006, Lee et al., 2006, Sato et al., 2006, Lee et al., 2005, Mok et al., 2005, Scuderi and Letsou, 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Kadrmas et al., 2004, Sawamura and Yamamoto, 2004, Riesgo-Escovar and Hafen, 1997, Riesgo-Escovar, 1996.10.3)
                    c-Jun N-terminal kinase
                    (Bausek, 2013, Macdonald et al., 2013, Vadász et al., 2012, Vandenabeele and Bertrand, 2012, Buchon et al., 2010, Lee et al., 2010, Warner et al., 2010, Rodahl et al., 2009, Umemori et al., 2009, Williams et al., 2007, Lee et al., 2006)
                    c-Jun aminoterminal kinase
                    (Lee et al., 2010)
                    c-Jun-N-terminal Kinase
                    (Liu et al., 2015, Mehlen et al., 2005)
                    pJNK
                    (Ahn et al., 2012)
                    Secondary FlyBase IDs
                    • FBgn0015248
                    • FBgn0032199
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 91 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    PDB - An information portal to biological macromolecular structures
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    References (1,299)