General Information
Symbol
Dmel\bsk
Species
D. melanogaster
Name
basket
Annotation Symbol
CG5680
Feature Type
FlyBase ID
FBgn0000229
Gene Model Status
Stock Availability
Enzyme Name (EC)
Mitogen-activated protein kinase (2.7.11.24)
Gene Snapshot
Basket (Bsk) is a serine/threonine-protein kinase, a key component of JNK pathway that phosphorylates the Jra transcription factor. Bsk roles include regulation of cell shape and stress response. [Date last reviewed: 2016-06-30]
Also Known As
JNK, DJNK, pJNK, D-JNK, basket
Genomic Location
Cytogenetic map
Sequence location
2L:10,247,502..10,250,501 [-]
Recombination map
2-40
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (P92208)
Molecular Function (see GO section for details)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.24)
Summaries
Gene Group Membership
CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES -
Conventional Mitogen-activated protein kinases (MAPK) are proline-directed protein serine/threonine kinases that are components of the MAPK signaling cascade. MAPKs are activated by dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop by MAPK kinases. (Adapted from PMID:21372320).
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependant manner. (Adapted from FBrf0222697 and FBrf0221727).
UniProt Contributed Function Data
Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity (PubMed:9224720). Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis (PubMed:8946915, PubMed:9224720, PubMed:10433922, PubMed:11784101). Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade (PubMed:22227521). Exhibits cytoprotective activity in neuronal cells in response to wounding to the integument (PubMed:22227521). Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure (PubMed:10433922, PubMed:11784101).
(UniProt, P92208)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
bsk: basket
Homozygous lethal; embryos have large dorsal anterior hole.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\bsk or the JBrowse view of Dmel\bsk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0080087
1535
372
FBtr0300982
1655
372
FBtr0302378
1797
372
Additional Transcript Data and Comments
Reported size (kB)
1.5 (northern blot)
1.85, 1.8 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0079676
43.0
372
6.39
FBpp0290204
43.0
372
6.39
FBpp0291573
43.0
372
6.39
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

372 aa isoforms: bsk-PB, bsk-PE, bsk-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
353 (aa); 49 (kD observed); 49 (kD predicted)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with MKP-4 (via tyrosine-protein phosphatase domain); the interaction dephosphorylates bsk.
(UniProt, P92208)
Post Translational Modification
Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme.
(UniProt, P92208)
Domain
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
(UniProt, P92208)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bsk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (52 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001171982
(assigned by GO_Central )
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN002372889
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001172432
(assigned by GO_Central )
Biological Process (42 terms)
Terms Based on Experimental Evidence (36 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:hiw; FB:FBgn0030600
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:mei-9; FB:FBgn0002707
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001172432
(assigned by GO_Central )
non-traceable author statement
traceable author statement
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001171982
(assigned by GO_Central )
non-traceable author statement
non-traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
bsk is expressed ubiquitously at low levels in early embryos. During gastrulation, high levels of bsk mRNA are expressed in cells involved in morphogenetic movements; the cephalic furrow, the anterior and posterior transverse folds, and the leading edge of the ventrolateral epidermis. Begininning in stages 8-9, expression is observed in the CNS and PNS. Expression persists in the CNS through larval stages. Expression is also observed in imaginal discs.
bsk transcripts are present at a low level in early cleavage stage embryos. During germ band extension, bsk transcripts are present in all germ layers. During germ band retraction, intense staining is seen in the epidermis and in the CNS. At stage 14, staining is increased in the CNS and is present in the lateral epidermis extending up to the amnioserosa. At stage 15, strong staining is observed in the CNS, the brain, and some peripheral neurons. Strong staining persists in the fully retracted CNS at stage 16. bsk expression is also observed in third instar larval imaginal discs. High levels of bsk transcripts are seen in the eye and wing imaginal discs. On northern blots, bsk transcripts are observed at all stages of development as well as in fat body and in a hemocyte cell line.
The 1.85kb bsk transcript is detected in early embryos.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
bsk protein is detected in the axons of Kenyon cells but not in the cell bodies or dendrites.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bsk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 21 )
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bsk
Allele of bsk
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of bsk
Deletions and Duplications ( 17 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
axon & dorsal cluster neuron, with Scer\GAL4ato.3.6
axon & dorsal cluster neuron | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
13 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
10 of 13
Yes
Yes
9 of 13
No
Yes
9 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
11 of 12
Yes
Yes
7 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (14)
13 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
15 of 15
Yes
Yes
5 of 15
No
Yes
4 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (20)
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
2 of 9
Yes
No
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (7)
4 of 15
Yes
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
3 of 12
Yes
No
2 of 12
No
No
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909O5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915068Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06A9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X065R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09G2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 3 )
    Allele
    Disease
    Evidence
    References
    inferred from mutant phenotype
    inferred from mutant phenotype
    model of  cancer
    in combination with DlUAS.cDa
    Interactions ( 5 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    suppressible
    External Data
    Subunit Structure (UniProtKB)
    Interacts with MKP-4 (via tyrosine-protein phosphatase domain); the interaction dephosphorylates bsk.
    (UniProt, P92208 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
    PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependant manner. (Adapted from FBrf0222697 and FBrf0221727).
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-40
    Cytogenetic map
    Sequence location
    2L:10,247,502..10,250,501 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    31B1-31B1
    Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    31B-31C
    (determined by in situ hybridisation)
    31B-31B
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (25)
    Genomic Clones (17)
    cDNA Clones (43)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: bsk CG5680
    Additional comments
    Other Comments
    bsk is required for axon pruning of mushroom body gamma neurons, but not for pruning of their dendrites. It promotes mushroom body axon pruning by reducing the membrane levels of the Fas2 protein.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
    The wg and bsk (JNK) signaling cascades collaborate to promote both dorsal closure and ventral patterning.
    bsk functions in the establishment of planar polarity in the eye.
    Show no or weak ommatidial precursor polarity phenotypes in imaginal tissues.
    msn acts through bsk in epithelial planar polarity (EPP) signalling.
    Genetic and over-expression assays show that dsh protein activates JNK cascades.
    Phylogenetic and functional relationships of MAPKs is studied based on 93 non-redundant full length sequences, 2 atomic structures and known functions of MAPKs.
    Leading edge cell identity and dorsal closure depend on a balance between bsk activation and puc repression.
    Jra in the embryo is a downstream target of the bsk signal transduction pathway during dorsal closure formation. The function of the bsk/Jra pathway is to control the localised expression of dpp. Both in the embryo and during photoreceptor cell determination Jra is not regulated by a pathway that involved rl.
    The bsk pathway is functionally linked to the dpp pathway, the bsk pathway controls dorsal closure at least in part by regulating dpp expression in the leading edge cells. dpp expression is reduced or absent in leading edge cells of embryos lacking bsk function. Transcription factors Jra and aop are required for dorsal closure. Results suggest that the bsk pathway governs dorsal closure at least partially by regulating dpp expression via phosphorylation of Jra and aop.
    bsk function is not required for cell fate specification in the eye.
    bsk mediates an immune response in cells in culture and morphogenesis in vivo.
    bsk embryos display relatively subtle defects in the nervous system, late in development. Brain and gut protrude from an unusually anterior dorsal hole.
    Non-complementing overlapping deficiences in and around Ror that only span a few kb also fail to complement EMS induced alleles of bsk.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 85 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Synonyms and Secondary IDs (37)
    Reported As
    Symbol Synonym
    JNK
    (Ahmed-de-Prado and Baonza, 2018, Das et al., 2018, de Vreede et al., 2018, Diwanji and Bergmann, 2018, Dutta et al., 2018, Feng et al., 2018, Searle and Pillus, 2018, Su et al., 2018, Takeda et al., 2018, Wang et al., 2018, Yang et al., 2018, Brace and DiAntonio, 2017, Fei et al., 2017, Hussain et al., 2017, Ismail et al., 2017, Khan et al., 2017, Lu et al., 2017, Pérez et al., 2017, Romani et al., 2017, Zhang et al., 2017, Aggarwal et al., 2016, Alfa and Kim, 2016, Chen et al., 2016, Feoktistov and Herman, 2016, Kaynar et al., 2016, Khoshnood et al., 2016, Saadin and Starz-Gaiano, 2016, Suijkerbuijk et al., 2016, Yadav and Tapadia, 2016, Yadav et al., 2016, Grifoni et al., 2015, Jasper, 2015, Kopp et al., 2015, Lashmanova et al., 2015, Neyen and Lemaitre, 2015, Santabárbara-Ruiz et al., 2015, Seeds et al., 2015, Shaukat et al., 2015, Su, 2015, Wang et al., 2015, Zhan et al., 2015, Zimmermann et al., 2015, Ballard et al., 2014, Cordero et al., 2014, Griciuc et al., 2014, Li et al., 2014, Thomas and Strutt, 2014, Zemolin et al., 2014, Dekanty and Milán, 2013, Ferrandon, 2013, Hada et al., 2013, Hwang et al., 2013, Langen et al., 2013, Pastor-Pareja and Xu, 2013, Petzoldt et al., 2013, Pronovost et al., 2013, Tang et al., 2013, Tian et al., 2013, Woodfield et al., 2013, Amoyel and Bach, 2012, Bond and Foley, 2012, Gistelinck et al., 2012, Gonda et al., 2012, Gowda et al., 2012, Kanao et al., 2012, Kang et al., 2012, Miura, 2012, Nam et al., 2012, Pallavi et al., 2012, Shlevkov and Morata, 2012, Spedale et al., 2012, Stevens and Page-McCaw, 2012, Vandenabeele and Bertrand, 2012, Wang et al., 2012, Bangi et al., 2011, Keller et al., 2011, Milton et al., 2011, Morata et al., 2011, Ohsawa et al., 2011, Sekine et al., 2011, Tower, 2011, Wang and Jin, 2011, Abu-Dayyeh et al., 2010, Ashton-Beaucage et al., 2010, Benitez et al., 2010, Bhuin and Roy, 2010, Buchon et al., 2010, Chen et al., 2010, Cordero et al., 2010, Falzone et al., 2010, Froldi et al., 2010, Gettings et al., 2010, Haghayeghi et al., 2010, Kim et al., 2010, Lee et al., 2010, Lee et al., 2010, Neisch et al., 2010, Radyuk et al., 2010, Rallis et al., 2010, Suganuma et al., 2010, Tamori et al., 2010, Warner et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Apidianakis et al., 2009, Baril et al., 2009, Bossuyt et al., 2009, Diangelo et al., 2009, Glavic et al., 2009, Guntermann et al., 2009, Hong et al., 2009, Lee et al., 2009, List et al., 2009, Liu et al., 2009, Rodahl et al., 2009, Tuxworth et al., 2009, Umemori et al., 2009, Williams, 2009, Wu et al., 2009, Wu et al., 2009, Bakal et al., 2008, Berger et al., 2008, Cui et al., 2008, Domingues and Ryoo, 2008, Franciscovich et al., 2008, Grima et al., 2008, Halme et al., 2008, Jimenez-Del-Rio et al., 2008, Jones et al., 2008, Lee et al., 2008, Lee et al., 2008, Llense and Martín-Blanco, 2008, McNamee and Brodsky, 2008, Melani et al., 2008, Sage et al., 2008, Wu et al., 2008, Balakireva et al., 2007, Bidla et al., 2007, Cinnamon et al., 2007, Fernández et al., 2007, Horiuchi et al., 2007, Kirchner et al., 2007, Kronhamn et al., 2007, Lecuit and Le Goff, 2007, Liu et al., 2007, Sackton et al., 2007, Sage et al., 2007, Waterhouse et al., 2007, Biswas et al., 2006, Bjorklund et al., 2006, Bovolenta et al., 2006, Delaney et al., 2006, Dionne et al., 2006, Herz et al., 2006, Homsy et al., 2006, Jordan et al., 2006, Lee et al., 2006, Luo et al., 2006, Maurange et al., 2006, Singh and Choi, 2006, Vidal et al., 2006, Anonymous, 2005, Bosch et al., 2005, Etter et al., 2005, Igaki et al., 2005, Ip, 2005, Kuttenkeuler et al., 2005, Mace et al., 2005, Mattila et al., 2005, Mehlen et al., 2005, Meller et al., 2005, Müller et al., 2005, Wech and Nagel, 2005, Brennan and Anderson, 2004, Chen et al., 2004, Donaldson and Duronio, 2004, Hay et al., 2004, Ishimaru et al., 2004, Kadrmas et al., 2004, McClure and Schubiger, 2004, Miotto et al., 2004, Park et al., 2004, Pilcher, 2004, Secombe et al., 2004, Udomsinprasert et al., 2004, Wells and Johnston, 2004, Yeo and Gautier, 2004, Hay and Guo, 2003, Hoffmann, 2003, Lee et al., 2003, Parkhurst and Delidakis, 2003, Sathyanarayana et al., 2003, Seyedoleslami Esfahani et al., 2003, Solnica-Krezel and Eaton, 2003, Wang et al., 2003, Adachi-Yamada and O'Connor, 2002, Aigaki et al., 2002, Galis et al., 2002, Jasper and Bohmann, 2002, Kuranaga et al., 2002, Liu and Moffat, 2002, Mlodzik, 2002, Muller et al., 2002, Noselli, 2002, Pandur et al., 2002, Ramet et al., 2002, Sathyanarayana et al., 2002, Tree et al., 2002, Verheyen et al., 2002, Wedlich, 2002, Ciapponi et al., 2001, Kockel et al., 2001, Muller and Littlewood-Evans, 2001, Pastor-Pareja et al., 2001, Pastor-Pareja et al., 2001, Reed et al., 2001, Settleman, 2001, Tootle and Rebay, 2001, Behrens, 2000, Fashena and Thomas, 2000, McEwen and Peifer, 2000, Morrison et al., 2000, Seidensticker and Behrens, 2000, Sokol, 2000, Blair, 1999, Mlodzik, 1999, Novak and Dedhar, 1999, Perrimon and Stern, 1999, Spana and Perrimon, 1999, Stronach and Perrimon, 1999, Yeaman et al., 1999, Boutros et al., 1998, Feiguin et al., 1998, Hall, 1998, Martin-Blanco et al., 1998, Anonymous, 1997, Hou et al., 1997, Jarvis and Schaefer, 1997, Kockel et al., 1997, Strutt et al., 1997, Harden et al., 1996)
    Junk
    bsk
    (Behrman et al., 2018, Bushnell et al., 2018, Dutta et al., 2018, Kumar and Tiwari, 2018, Mondal et al., 2018, Paul et al., 2018, Poon et al., 2018, Tsai et al., 2018, Wang et al., 2018, Yang et al., 2018, Yu et al., 2018, Aggarwal et al., 2017, Akbergenova and Littleton, 2017, Borgen et al., 2017, Casas-Tintó et al., 2017, Chabu et al., 2017, He et al., 2017, Katheder et al., 2017, Kenmoku et al., 2017, Lee et al., 2017, Li et al., 2017, Ma et al., 2017, Ma et al., 2017, Ma et al., 2017, Manent et al., 2017, Nazario-Yepiz and Riesgo-Escovar, 2017, O'Farrell et al., 2017, Pérez et al., 2017, Poulton et al., 2017, Taylor et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Tue et al., 2017, Xie et al., 2017, Casas-Tintó et al., 2016, Chen et al., 2016, Hou et al., 2016, Huang et al., 2016, Ko et al., 2016, Levinson and Cagan, 2016, Ma et al., 2016, Rao et al., 2016, Tare et al., 2016, Voelzmann et al., 2016, Weavers et al., 2016, Willsey et al., 2016, Yasin et al., 2016, Yoo et al., 2016, Zhang et al., 2016, Zhang et al., 2016, Zhang et al., 2016, Bornstein et al., 2015, Chen et al., 2015, Grotewiel and Bettinger, 2015, Külshammer et al., 2015, Liu et al., 2015, Moreno et al., 2015, Pearce et al., 2015, Ríos-Barrera et al., 2015, Sansone et al., 2015, Vinatier et al., 2015, Wang et al., 2015, Wong et al., 2015, Woodcock et al., 2015, Xia et al., 2015, Zeidler, 2015.2.13, Zhai et al., 2015, Zhan et al., 2015, Zhang et al., 2015, Brace et al., 2014, Chabu and Xu, 2014, Fernández et al., 2014, Gao et al., 2014, Gersten et al., 2014, Inamdar et al., 2014, Kuang et al., 2014, Macagno et al., 2014, Milet et al., 2014, Morishita et al., 2014, Okumura et al., 2014, Pereira et al., 2014, Radermacher et al., 2014, Rauskolb et al., 2014, Rudrapatna et al., 2014, Sass and Ostrow, 2014, Shen et al., 2014, Soares et al., 2014, Sopko et al., 2014, Stone et al., 2014, Wang et al., 2014, Wong et al., 2014, Yanai et al., 2014, Burra et al., 2013, Carter, 2013, Das et al., 2013, Hirabayashi et al., 2013, Humphreys et al., 2013, Hwang et al., 2013, Külshammer and Uhlirova, 2013, Langen et al., 2013, Nowak et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Rudrapatna et al., 2013, Telonis-Scott et al., 2013, Tian et al., 2013, Valakh et al., 2013, Villicaña et al., 2013, Woodfield et al., 2013, Yang et al., 2013, Ahn et al., 2012, Brock et al., 2012, Etchegaray et al., 2012, Förster and Luschnig, 2012, Gonda et al., 2012, Graves et al., 2012, Hong et al., 2012, Huang et al., 2012, Inamdar et al., 2012, Jemc et al., 2012, Kanao et al., 2012, Kapfhamer et al., 2012, Lu et al., 2012, Ma et al., 2012, Marchal et al., 2012, Pezzulo et al., 2012, Senthilan et al., 2012, Stern et al., 2012, Tsuzuki et al., 2012, Vadász et al., 2012, Yoshioka et al., 2012, Boyd et al., 2011, Brumby et al., 2011, Friedman et al., 2011, Huang et al., 2011, Kanda et al., 2011, Keller et al., 2011, Kuranaga et al., 2011, Maher et al., 2011, Marinho et al., 2011, Mathew et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Seisenbacher et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Tripura et al., 2011, Wertheim et al., 2011, Zhao et al., 2011, Baek et al., 2010, Beam and Moberg, 2010, Bergantiños et al., 2010, Bhuin and Roy, 2010, Chen et al., 2010, Chi et al., 2010, Djiane and Mlodzik, 2010, Froldi et al., 2010, Garlena et al., 2010, Gettings et al., 2010, Grzeschik et al., 2010, Hwang et al., 2010, Kim et al., 2010, Kim et al., 2010, Kwon et al., 2010, Lam et al., 2010, Lennox and Stronach, 2010, Neisch et al., 2010, Padash-Barmchi et al., 2010, Portela et al., 2010, Radyuk et al., 2010, Rallis et al., 2010, Shen et al., 2010, Sun et al., 2010, Umehara et al., 2010, Wu et al., 2010, Xiong et al., 2010, Yavari et al., 2010, Zhang et al., 2010, Baril et al., 2009, Bossuyt et al., 2009, Chang and Neufeld, 2009, Chang and Neufeld, 2009, Hull-Thompson et al., 2009, Igaki et al., 2009, Karpac et al., 2009, Lee et al., 2009, Leong et al., 2009, Maezawa et al., 2009, Massaro et al., 2009, Ohayon et al., 2009, Owusu-Ansah and Banerjee, 2009, Shen and Ganetzky, 2009, Solon et al., 2009, Tiwari and Roy, 2009, Tuxworth et al., 2009, Weake et al., 2009, Widmann and Dahmann, 2009, Wu et al., 2009, Wu et al., 2009, Wu et al., 2009, Babcock et al., 2008, Bates et al., 2008, Biteau et al., 2008, Caussinus et al., 2008, Davis et al., 2008, Fiehler and Wolff, 2008, Franciscovich et al., 2008, Grima et al., 2008, Griswold et al., 2008, Jones et al., 2008, Llense and Martín-Blanco, 2008, Owusu-Ansah et al., 2008, Shimizu et al., 2008, Uthaman et al., 2008, Yoshioka et al., 2008, Abraham et al., 2007, Bidla et al., 2007, Curtis et al., 2007, Horiuchi et al., 2007, Junion et al., 2007, Kirchner et al., 2007, Lee et al., 2007, Mathieu et al., 2007, Montrasio et al., 2007, Muñoz-Descalzo et al., 2007, Neuman-Silberberg, 2007, Peralta et al., 2007, Pfleger et al., 2007, Srivastava et al., 2007, Tyler et al., 2007, Valanne et al., 2007, Wada et al., 2007, Walther and Pichaud, 2007, Williams et al., 2007, Xue et al., 2007, Balakireva et al., 2006, Cerrato et al., 2006, Christensen and Cook, 2006.8.30, Guichard et al., 2006, Homsy et al., 2006, Igaki et al., 2006, Janody and Treisman, 2006, Lee et al., 2006, Polaski et al., 2006, Sato et al., 2006, Singh et al., 2006, Srahna et al., 2006, Uhlirova and Bohmann, 2006, He et al., 2005, Kim et al., 2005, Lee et al., 2005, Mace et al., 2005, Mace et al., 2005, McEwen and Peifer, 2005, Scuderi and Letsou, 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Fanto and McNeill, 2004, Kadrmas et al., 2004, Sawamura and Yamamoto, 2004, Stanyon et al., 2004, Cha et al., 2003, Harvey et al., 2003, Jenny et al., 2003, Pantalacci, 2003, Pantalacci et al., 2003, Mihaly et al., 2001)
    jnk (bsk)
    Name Synonyms
    JUN kinase
    Jun NH2-terminal Kinase
    Jun-N Terminal kinase
    Jun-N-terminal Kinase
    Jun-N-terminal kinase
    basket
    (Paul et al., 2018, Bayona-Feliu et al., 2017, Lu et al., 2017, Tomita et al., 2017, Yamaguchi et al., 2017, Nässel and Vanden Broeck, 2016, Wieschaus and Nüsslein-Volhard, 2016, Freeman, 2015, Ojelade et al., 2015, Zhai et al., 2015, Zhan et al., 2015, Gao et al., 2014, Kuang et al., 2014, Morishita et al., 2014, Pereira et al., 2014, Rudrapatna et al., 2014, Sass and Ostrow, 2014, Singh et al., 2014, Soares et al., 2014, Freeman et al., 2013, Hombría and Serras, 2013, Humphreys et al., 2013, Karpac et al., 2013, Ortega-Arellano et al., 2013, Pérez-Garijo et al., 2013, Rallis et al., 2013, Woodfield et al., 2013, Etchegaray et al., 2012, Inamdar et al., 2012, Jemc et al., 2012, Kang et al., 2012, Kapfhamer et al., 2012, Vadász et al., 2012, Boyd et al., 2011, Kraut, 2011, Muñoz-Soriano and Paricio, 2011, Sinenko et al., 2011, Sinenko et al., 2011, Bergantiños et al., 2010, Froldi et al., 2010, Gettings et al., 2010, Hwang et al., 2010, Lennox and Stronach, 2010, Yavari et al., 2010, Zhao et al., 2010, Buchon et al., 2009, Corl et al., 2009, Leong et al., 2009, Owusu-Ansah and Banerjee, 2009, Rodahl et al., 2009, Shen and Ganetzky, 2009, Weake et al., 2009, Babcock et al., 2008, Berger et al., 2008, Fiehler and Wolff, 2008, Grima et al., 2008, Melani et al., 2008, Wu et al., 2008, Yoshioka et al., 2008, Bidla et al., 2007, Halme and Hariharan, 2007, Montrasio et al., 2007, Neuman-Silberberg, 2007, Peralta et al., 2007, Pfleger et al., 2007, Sackton et al., 2007, Walther and Pichaud, 2007, Williams et al., 2007, Cerrato et al., 2006, Hashimoto and Yamaguchi, 2006, Herz et al., 2006, Homsy et al., 2006, Lee et al., 2006, Sato et al., 2006, Lee et al., 2005, Mok et al., 2005, Scuderi and Letsou, 2005, Terashima and Bownes, 2005, Wech and Nagel, 2005, Kadrmas et al., 2004, Sawamura and Yamamoto, 2004, Riesgo-Escovar and Hafen, 1997, Riesgo-Escovar, 1996.10.3)
    c-Jun aminoterminal kinase
    c-Jun-N-terminal Kinase
    Secondary FlyBase IDs
    • FBgn0015248
    • FBgn0032199
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (905)