A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\bss

General Information
SymbolDmel\bssSpeciesD. melanogaster
Namebang senselessAnnotation symbol
Feature typegeneFlyBase IDFBgn0000231
Gene Model StatusUnannotated Stock availability None publicly available
Genomic Location
Chromosome (arm)Recombination map1-54
Cytogenetic mapSequence location
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Automatically generated summary

See sections below for more information
The gene bang senseless is referred to in FlyBase by the symbol Dmel\bss (FBgn0000231). It is a gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: response to hypoxia; response to mechanical stimulus; cellular process; mechanosensory behavior. 3 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 1 dorsal longitudinal muscle; central nervous system. It has no annotated transcripts. Gene has not been localized to the genome sequence.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
bas: bang sensitive (J.C. Hall)
Striking culture vial sharply on hard surface immobilizes bas flies for 30-40 seconds. Rapid recovery followed by refractory period of an hour. Suppressed by napts at permissive temperatures; at temperatures above 37.5 bas flies quickly paralyzed; no detectable physiological abnormalities at neuromuscular junction in bas larvae (Ganetsky and Wu). In experiments on photoreceptor function, recovery of prolonged depolarization afterpotentials (induced by strong blue light) abnormally slow following exposure to orange light (Homyk and Pye, 1989, J. Neurogenet. 5: 37-48).
bss: bang senseless (J.C. Hall)
Mechanical shock or vortexing induces paralysis lasting for 2-3 minutes; heterozygous female are paralized for 40-50 seconds. Homozygotes and hemizygotes have abnormally prolonged release of neurotransmitter at larval neuromuscular junctions, which is associated with multiple firing of action potentials in the nerves; behavioral and electrophysiological phenotypes suppressed by napts at its permissive (low) temperature.
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FB2011_10
FB2012_01
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hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
1-54
(Ganetzky and Wu, 1982)
Left of (cM)
(Ganetzky and Wu, 1982)
Right of (cM)
(Ganetzky and Wu, 1982)
Notes
Mapping based on 107 recombinants.
(Ganetzky and Wu, 1982)
Mapped adjacent to eas. Mapped adjacent to nonA.
(Reynolds and Tanouye, 1996)
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Comments on Gene Model
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Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
3.0 (northern blot)
(Canaple et al., 1997)
1.9 (longest cDNA)
(Lehming et al., 1994)
Comments
External Data
Crossreferences
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Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
393 (aa)
(Lehming et al., 1994)
Comments
In vitro assays demonstrate that Dsp1 can switch several proteins of the Rel family, including Dl and NF-ΚB, from transcriptional activators to repressors. This switch requires the presence of a negative regulatory element (NRE) sequence adjacent to the Dl binding site.
(Lehming et al., 1994, Lehming et al., 1994)
External Data
Linkouts
Crossreferences
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage | early  
 
(Lehming et al., 1994)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
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Linkouts
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Other Phenotypes
Allele
bang sensitive
bang sensitive | semidominant
behavior defective | semidominant
neurophysiology defective
neurophysiology defective | semidominant
paralytic
paralytic | semidominant
Phenotype manifest in
Allele
abdominal 1 dorsal longitudinal muscle
central nervous system
hide Classical Alleles ( 3 )
For All Classical Alleles Show

Allele of bssClassMutagenStocksKnown lesion
bss1
0 --
bss2
0 --
bssunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show

Allele of bssClassMutagenStocksKnown lesion
hide Aneuploid Aberrations
Not disrupted in
(Rutherford, 1995)
(Ganetzky and Wu, 1982)
(Ganetzky and Wu, 1982)
(Ganetzky and Wu, 1982)
(Rutherford, 1995)
Not duplicated in
(Ganetzky and Wu, 1982)
(Ganetzky and Wu, 1982)
Disrupted in
(Rutherford, 1995)
(Rutherford, 1995)
(Rutherford, 1995)
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Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
hide Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
cellular process
inferred from mutant phenotype
(Boutros et al., 2004)
mechanosensory behavior
inferred from mutant phenotype
(Engel and Wu, 1994)
response to hypoxia
inferred from direct assay
(Whelan et al., 2010)
response to mechanical stimulus
inferred from genetic interaction with kcc
(Hekmat-Scafe et al., 2006)
inferred from mutant phenotype
(Engel and Wu, 1994)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
synaptic transmission
traceable author statement
(Engel and Wu, 1994)
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
gene
 
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Protein-protein
Interacting group
Assay
References
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Interacts with
Please look at the allele data for full details of the genetic interactions
bss allele
Gene
References
bss1
esg
(Hekmat-Scafe et al., 2005)
sna
(Hekmat-Scafe et al., 2005)
unspecified
mle
(Ganetzky and Wu, 1982)
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DroID - A comprehensive database of gene and protein interactions.
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Genome-wide drosophilid orthologs
Curated drosophilid orthologs
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hide Genomic Clones ( 0 )
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cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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Linkouts
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Source for database identity of
Source for database merge of
Additional comments
"bss" stated to correspond to "Dsp1".
(Reynolds and Tanouye, 1998)
hide Other Comments
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
(Boutros et al., 2004)
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
(Boutros et al., 2004)
Intragenic and extragenic suppressors of bss are isolated using an X ray screen of bss mutants for loss of paralytic behaviour.
(Schultz et al., 1997)
Separable by recombination from eas, which causes a similar phenotype and to which bss is closely linked.
 
Mechanical shock or vortexing induces paralysis lasting for 2-3 minutes; heterozygous female are paralysed for 40-50 seconds. Homozygotes and hemizygotes have abnormally prolonged release of neurotransmitter at larval neuromuscular junctions, which is associated with multiple firing of action potentials in the nerves; behavioral and electrophysiological phenotypes suppressed by mlenap-ts1 at its permissive (low) temperature.
 
hide External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
DroID - A comprehensive database of gene and protein interactions.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym
bas
(Hall, 1992)
bss
(Fergestad et al., 2006, Fergestad et al., 2008, Reynolds et al., 2004, Tussey et al., 2008, Kuebler and Tanouye, 2000, Song et al., 2007, Hekmat-Scafe et al., 2006, Kuebler et al., 2001, Song and Tanouye, 2006, Lee and Wu, 2006, Song et al., 2008, Hekmat-Scafe et al., 2010, Whelan et al., 2010, Kuebler and Tanouye, 2002, Tan et al., 2004)
Name Synonym
bang senseless
(Fergestad et al., 2008, Tussey et al., 2008, Kuebler and Tanouye, 2000, Kuebler et al., 2001, Whelan et al., 2010, Kuebler and Tanouye, 2002, Tan et al., 2004)
bangsenseless
(Reynolds et al., 2004)
bang-senseless
(Song and Tanouye, 2006, Lee and Wu, 2006, Hekmat-Scafe et al., 2010)
bang sensitive
(Hall, 1992)
Secondary FlyBase IDs
hide References ( 47 )
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hide Recent research papers ( 2 )
Hekmat-Scafe et al., 2010, Genetics 184(1): 171--183
Seizure sensitivity is ameliorated by targeted expression of k+-cl- cotransporter function in the mushroom body of the Drosophila brain. [FBrf0209683]
Whelan et al., 2010, Brain Res. 1316C: 120--128
Sensitivity to seizure-like activity in Drosophila following acute hypoxia and hypercapnia. [FBrf0209944]
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