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General Information
Symbol
Dmel\c(3)G
Species
D. melanogaster
Name
crossover suppressor on 3 of Gowen
Annotation Symbol
CG17604
Feature Type
FlyBase ID
FBgn0000246
Gene Model Status
Stock Availability
Gene Snapshot
crossover suppressor on 3 of Gowen (c(3)G) encodes the transerve filament protein of the synaptonemal complex. It is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I. [Date last reviewed: 2019-09-26]
Also Known As

c3G, crossover suppressor on 3 of Gowan

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:15,789,473..15,792,579 [-]
Recombination map

3-58

RefSeq locus
NT_033777 REGION:15789473..15792579
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    c(3)G: crossover suppressor in chromosome 3 of Gowen
    Eliminates meiotic crossing over in homozygous females. First-division nondisjunction and chromosome loss frequent (30% for X, 2, and 3; 20% for 4); second division normal; exceptions more frequent at 25 than at 19. Production of triploids and intersexes 300-500 times normal. Egg hatch very low. Synaptonemal complexes absent from oocytes (Meyer), and both duration of meiotic prophase and number of 16-cell cysts per germarium reduced in c(3)G/c(3)G females (Smith and King, 1969, Genetics 60: 335-51). Meiotic loss of ring chromosomes increased in c(3)G females (Sandler, 1961, Nat. Cancer Inst. Monogr. 18: 243-73). No meiotic effects in homozygous males. In c(3)G/+ females, both intergenic recombination (Hinton, 1966, Genetics 53: 157-64) and the subset of intragenic recombination accompanied by recombination of flanking markers (Carlson, 1972, Genet. Res. 19: 129-32) increased. Somatic pairing (Semjenov, 1979, Tsitologiya 21: 1353-55) and somatic crossing over (Le Clerc, 1946, Science 103: 553-54) normal in c(3)G homozygotes; however, reported to be deficient for one of two X-ray-induced reactions leading to mitotic exchange (Handle, 1974, Molec. Gen. Genet. 128: 233-39). Heterochromatic interchanges inducible in oocytes of homozygous females by X irradiation (Roberts, 1969, Genetics 47: 387-408; Wurgler, Graf, Ruch, Beck, and Steiner, 1978, Arch. Genet. 51: 217-42). Oocytes of homozygous females show increased sensitivity to X irradiation and lack the normally observed fractionation effect (Watson, 1969, Mutat. Res. 8: 91-100; 1972, Mutat. Res. 14: 299-307); Watson (1972) also reports increased sensitivity of c(3)G-bearing sperm from c(3)G/+ males to translocation induction. RK3.
    c(3)G68
    Effects slightly more severe than in c(3)G. Meiotic recombination absent; first-division nondisjunction and loss high (40% for X, 2, and 3; 30% for 4). Low level of nondisjunction in second meiotic division. Oocytes of homozygous females lack synaptonemal complex (Carpenter).
    c(3)GOR28
    Hypomorphic allele. Homozygous females show polarized reduction of recombination to 4.3% between y and f with greatest reduction distally. X-chromosome nondisjunction temperature sensitive; 16.7% at 25; reduced to 10.2% in oocytes exposed to 17 during metaphase I and anaphase I; no X-chromosome loss at either temperature. Synaptonemal complex reduced in quantity and abnormal in structure. c(3)GOR28/Df(3R)sbd105 females exhibit no recombination and 32% X-chromosome nondisjunction.
    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\c(3)G for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.41

    Gene model reviewed during 5.47

    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0083194
    2617
    744
    FBtr0083195
    2594
    744
    FBtr0083196
    2629
    744
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0082648
    85.8
    744
    6.12
    FBpp0082649
    85.8
    744
    6.12
    FBpp0082650
    85.8
    744
    6.12
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    744 aa isoforms: c(3)G-PA, c(3)G-PB, c(3)G-PC
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\c(3)G using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Polypeptide Expression
    immunolocalization
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    western blot
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Descriptive Data

    c(3)G immunoreactivity becomes concentrated in the pro-oocyte as the germline cyst progresses through early development in the germarium.

    c(3)G protein is detected in a ribbon pattern along the length of meiotic chromosomes during pachytene in germarium region 2a of the ovary. Staining persists through stage 7 of oogenesis.

    Marker for
    Subcellular Localization
    CV Term
    Evidence
    References
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\c(3)G in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    Alleles, Insertions, and Transgenic Constructs
    Phenotypes
    Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (2)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    1 of 15
    Yes
    Yes
    1 of 15
    Yes
    No
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (10)
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    No
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    1 of 9
    Yes
    Yes
    Saccharomyces cerevisiae (Brewer's yeast) (1)
    1 of 15
    Yes
    Yes
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919042J )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
    No non-Drosophilid orthologies identified
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-58

      Cytogenetic map
      Sequence location
      3R:15,789,473..15,792,579 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      89A5-89A5
      Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      89A2-89A2
      Experimentally Determined Recombination Data
      Location

      3-57.4

      Left of (cM)
      Right of (cM)
      Notes

      P{wB}1-1 maps 0.15cM to the right of c(3)G.

      Stocks and Reagents
      Stocks (5)
      Genomic Clones (15)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (69)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      polyclonal antibody

      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: c(3)G CG17604

      Additional comments

      "CG17604" may correspond to c(3)G, based on sequence of "CG17604" and mutant phenotype of c(3)G.

      Other Comments

      c(3)G is involved in the maintenance of euchromatic sister chromatid cohesion as well as in the maintenance of homolog-homolog association. c(3)G oocytes show normal pairing in the heterochromatin.

      c(3)G protein is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase in females, consistent with a role as a synaptonemal complex protein present on meiotic bivalents.

      c(3)G is required for recombination and synaptonemal complex assembly.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 37 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Synonyms and Secondary IDs (11)
      Reported As
      Symbol Synonym
      C(3)G
      (Rubin et al., 2020, Hughes et al., 2019, Singh et al., 2018, Cahoon et al., 2017, Rog et al., 2017, Gyuricza et al., 2016, Zhaunova et al., 2016, Da Ines and White, 2015, Kurdzo and Dawson, 2015, Obeso et al., 2014, Urban et al., 2014, Weng et al., 2014, Iovino et al., 2013, Leibfried et al., 2013, Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013, Yan and McKee, 2013, Anand and Kai, 2012, Morris and Spradling, 2012, Pek et al., 2012, Rincon-Arano et al., 2012, Senger et al., 2011, Fichelson et al., 2010, Janic et al., 2010, Lancaster et al., 2010, Lewandowski et al., 2010, Ong and Tan, 2010, Ong et al., 2010, Patil and Kai, 2010, Tastan et al., 2010, Wang et al., 2010, Joyce and McKim, 2009, Narbonne-Reveau and Lilly, 2009, Ozdowski et al., 2009, Peng and Karpen, 2009, Resnick et al., 2009, Benoit et al., 2008, Blumenstiel et al., 2008, Gause et al., 2008, Zhou and Bickel, 2008, Barbosa et al., 2007, Chen et al., 2007, Lake et al., 2007, Lim and Kai, 2007, Mukai et al., 2007, Parma et al., 2007, Jeffress et al., 2006, McCaffrey et al., 2006, Mehrotra and McKim, 2006, Mirouse et al., 2006, Page and Hawley, 2006, Sugimura and Lilly, 2006, Gong et al., 2005, Thomas et al., 2005, Heidmann et al., 2004, Mehrotra et al., 2004, Roper and Brown, 2004, Webber et al., 2004, Findley et al., 2003, Manheim and McKim, 2003, Staeva-Vieira et al., 2003, Manheim and McKim, 2002, Page et al., 2002, Huynh and St. Johnston, 2000, Santos, 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
      cx
      Name Synonyms
      Crossover suppressor on 3 of Gowen
      crossover suppressor in chromosome 3 of Gowen
      crossover suppressor on 3 of Gowan
      crossover suppressor on 3 of Gowen
      Secondary FlyBase IDs
      • FBgn0038362
      • FBgn0063641
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (190)