FlyBase Gene Report: Dmel\c(3)G

General Information

Symbol

Dmel\c(3)G

Species

D. melanogaster

Name

crossover suppressor on 3 of Gowen

Annotation Symbol

CG17604

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000246

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

crossover suppressor on 3 of Gowen (c(3)G) encodes the transerve filament protein of the synaptonemal complex. It is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

c3G, crossover suppressor on 3 of Gowan

Key Links

Genomic Location

Cytogenetic map

89A5-89A5

Sequence location

3R:15,789,473..15,792,579 [-]

Recombination map

3-58

RefSeq locus

NT_033777 REGION:15789473..15792579

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in reciprocal meiotic recombination

inferred from mutant phenotype

(Joyce and McKim, 2009)

involved_in synaptonemal complex assembly

inferred from mutant phenotype

(Joyce and McKim, 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in synaptonemal complex

inferred from direct assay

(Iida and Lilly, 2004, Manheim and McKim, 2003, Page and Hawley, 2001)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

c(3)G: crossover suppressor in chromosome 3 of Gowen

Eliminates meiotic crossing over in homozygous females. First-division nondisjunction and chromosome loss frequent (30% for X, 2, and 3; 20% for 4); second division normal; exceptions more frequent at 25 than at 19. Production of triploids and intersexes 300-500 times normal. Egg hatch very low. Synaptonemal complexes absent from oocytes (Meyer), and both duration of meiotic prophase and number of 16-cell cysts per germarium reduced in c(3)G/c(3)G females (Smith and King, 1969, Genetics 60: 335-51). Meiotic loss of ring chromosomes increased in c(3)G females (Sandler, 1961, Nat. Cancer Inst. Monogr. 18: 243-73). No meiotic effects in homozygous males. In c(3)G/+ females, both intergenic recombination (Hinton, 1966, Genetics 53: 157-64) and the subset of intragenic recombination accompanied by recombination of flanking markers (Carlson, 1972, Genet. Res. 19: 129-32) increased. Somatic pairing (Semjenov, 1979, Tsitologiya 21: 1353-55) and somatic crossing over (Le Clerc, 1946, Science 103: 553-54) normal in c(3)G homozygotes; however, reported to be deficient for one of two X-ray-induced reactions leading to mitotic exchange (Handle, 1974, Molec. Gen. Genet. 128: 233-39). Heterochromatic interchanges inducible in oocytes of homozygous females by X irradiation (Roberts, 1969, Genetics 47: 387-408; Wurgler, Graf, Ruch, Beck, and Steiner, 1978, Arch. Genet. 51: 217-42). Oocytes of homozygous females show increased sensitivity to X irradiation and lack the normally observed fractionation effect (Watson, 1969, Mutat. Res. 8: 91-100; 1972, Mutat. Res. 14: 299-307); Watson (1972) also reports increased sensitivity of c(3)G-bearing sperm from c(3)G/+ males to translocation induction. RK3.

c(3)G68

Effects slightly more severe than in c(3)G. Meiotic recombination absent; first-division nondisjunction and loss high (40% for X, 2, and 3; 30% for 4). Low level of nondisjunction in second meiotic division. Oocytes of homozygous females lack synaptonemal complex (Carpenter).

c(3)GOR28

Hypomorphic allele. Homozygous females show polarized reduction of recombination to 4.3% between y and f with greatest reduction distally. X-chromosome nondisjunction temperature sensitive; 16.7% at 25; reduced to 10.2% in oocytes exposed to 17 during metaphase I and anaphase I; no X-chromosome loss at either temperature. Synaptonemal complex reduced in quantity and abnormal in structure. c(3)GOR28/Df(3R)sbd105 females exhibit no recombination and 32% X-chromosome nondisjunction.

Summary (Interactive Fly)

transverse element of the synaptonemal complex, a meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions - required for centromere separation in Pp1-87B RNAi oocytes

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\c(3)G for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VF37)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

c(3)G-RA

FBtr0083194

NM_142233

2617

744

c(3)G-RB

FBtr0083195

NM_169670

2594

744

c(3)G-RC

FBtr0083196

NM_169671

2629

744

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

c(3)G-PA

FBpp0082648

85.8

744

6.12

FBpp0082649

85.8

744

6.12

FBpp0082650

85.8

744

6.12

Q9VF37

NP_732066

AAN13676

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

744 aa isoforms: c(3)G-PA, c(3)G-PB, c(3)G-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\c(3)G using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

c(3)G_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

organism

• pole plasm

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

embryonic stage 9 -- 10

germline cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

fat body/gonad primordium

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

germline cell

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

oocyte

• synaptonemal complex

(Iida and Lilly, 2004)

adult stage | female & oogenesis

female germline cyst

(Ong and Tan, 2010)

ovary

• synaptonemal complex

(Rojas-Ríos et al., 2015)

adult stage oogenesis stage S1 -- S7

presumptive oocyte & oocyte

• chromosome

(Manheim and McKim, 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ovary

(Iida and Lilly, 2004)

Additional Descriptive Data

c(3)G immunoreactivity becomes concentrated in the pro-oocyte as the germline cyst progresses through early development in the germarium.

(Stevens et al., 2009)

c(3)G protein is detected in a ribbon pattern along the length of meiotic chromosomes during pachytene in germarium region 2a of the ovary. Staining persists through stage 7 of oogenesis.

(Manheim and McKim, 2003)

Marker for

oocyte

(Singh et al., 2018)

synaptonemal complex

(Rojas-Ríos et al., 2015, Parma et al., 2007, Iida and Lilly, 2004)

Subcellular Localization

CV Term

Evidence

References

located_in synaptonemal complex

inferred from direct assay

(Iida and Lilly, 2004, Manheim and McKim, 2003, Page and Hawley, 2001)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\c(3)G in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\c(3)G

View exonic expression by tissue for Dmel\c(3)G

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000246

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47765/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000246

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000246

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000246

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17604

Flygut - An atlas of the Drosophila adult midgut

FBgn0000246

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of c(3)G

Transgenic constructs containing regulatory region of c(3)G

Aberrations (Deficiencies and Duplications) ( 19 )

Inferred from experimentation ( 19 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

c(3)G^GD9424

viable, with Scer\GAL4^Mef2.PR

c(3)G^GD9424

viable, with Scer\GAL4^pnr-MD237

c(3)G^GD9424

viable, with Scer\GAL4^tin.CΔ4

c(3)G^GD9424

Other Phenotypes

Allele

abnormal cell number | oogenesis, with Scer\GAL4^nanos.PU

c(3)G^HMJ30046

abnormal meiotic cell cycle

c(3)G^unspecified

abnormal meiotic cell cycle | female

abnormal meiotic cell cycle | female | recessive

c(3)G^ccΔ3

abnormal meiotic cell cycle | recessive

c(3)G⁶⁸

abnormal stress response

c(3)G⁶⁸

wild-type

c(3)G^+tX203

Phenotype manifest in

Allele

chromosome, centromeric region | oogenesis

c(3)G^ccΔ3

chromosome | oogenesis

chromosome | oogenesis | progressive

germarium, with Scer\GAL4^nanos.PU

c(3)G^HMJ30046

germarium & nuclear chromosome

c(3)G⁶⁸

meiotic anaphase I

c(3)G^unspecified

meiotic cell cycle

c(3)G^unspecified

meiotic metaphase I

c(3)G^unspecified

nurse cell & nuclear chromosome

c(3)G⁶⁸

oocyte & meiosis & nuclear chromosome

c(3)G⁶⁸

polytene chromosome chromocenter

c(3)G^unspecified

synaptonemal complex

synaptonemal complex, with Scer\GAL4^{VP16.nanos.UTR}, c(3)G⁶⁸

c(3)G^{Cdel.UASp.Tag:FLAG}

synaptonemal complex, with Scer\GAL4^{VP16.nanos.UTR}, c(3)G^{Cdel.UASp.Tag:FLAG}

c(3)G⁶⁸

synaptonemal complex (with c(3)G⁶⁸), with Scer\GAL4^{VP16.nanos.UTR}

c(3)G^{Cdel.UASp.Tag:FLAG}

synaptonemal complex (with c(3)G^{Cdel.UASp.Tag:FLAG}), with Scer\GAL4^{VP16.nanos.UTR}

c(3)G⁶⁸

synaptonemal complex | oogenesis

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\LAMA1

1 of 14

Yes

Hsap\LAMA2

1 of 14

Yes

Hsap\LAMA3

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (1)

Drer\lama5

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\epi-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004993

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (9)

Atha\AT1G65010

1 of 13

Yes

Atha\AT3G02930

1 of 13

Yes

Atha\AT4G27595

1 of 13

Yes

Atha\AT4G32190

1 of 13

Yes

Atha\AT4G40020

1 of 13

Yes

Atha\AT5G16730

1 of 13

Yes

Atha\ATGRIP

1 of 13

Yes

Atha\ZYP1a

1 of 13

Yes

Atha\ZYP1b

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:c(3)G. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

c(3)G

enhanceable

vilya

(Billmyre et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

okr

suppressible

c(3)G

(Ghabrial and Schupbach, 1999)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70923

DroID - A comprehensive database of gene and protein interactions.

FBgn0000246

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-58

Cytogenetic map

89A5-89A5

Sequence location

3R:15,789,473..15,792,579 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89A5-89A5

Limits computationally determined from genome sequence between P{lacW}MRG15^j6A3 and P{PZ}l(3)06536⁰⁶⁵³⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

89A2-89A2

(Szauter, 1998)

Experimentally Determined Recombination Data

Location

3-58

(FlyBase, 2016)

3-57.6

(Comeron et al., 2012)

3-57.4

Left of (cM)

Right of (cM)

cv-c

Notes

P{wB}1-1 maps 0.15cM to the right of c(3)G.

(Szauter, 1998)

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30110

w¹¹¹⁸; P{EP}c(3)G^G5001

85245

w¹¹¹⁸; PBac{WH}c(3)G^f05971

62969

y¹ v¹; P{TRiP.HMJ30046}attP40

606

speck²; st¹ c(3)G¹ ca¹/TM1

Kyoto

106004

speck²; st¹ c(3)G¹ ca¹/TM1

NIG-Fly

17604R-3

P{NIG.17604R}3

HMJ30046

y¹ v¹; P{TRiP.HMJ30046}attP40/CyO

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (67)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI01435

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000246

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000246

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Urban et al., 2014, Iida and Lilly, 2004)

monoclonal

(Christophorou et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

c(3)G is involved in the maintenance of euchromatic sister chromatid cohesion as well as in the maintenance of homolog-homolog association. c(3)G oocytes show normal pairing in the heterochromatin.

(Gong et al., 2005)

c(3)G protein is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase in females, consistent with a role as a synaptonemal complex protein present on meiotic bivalents.

(Page and Hawley, 2001)

c(3)G is required for recombination and synaptonemal complex assembly.

(Thatcher and Szauter, 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: c(3)G CG17604

(Page and Hawley, 2001)

Additional comments

"CG17604" may correspond to c(3)G, based on sequence of "CG17604" and mutant phenotype of c(3)G.

(Grishaeva et al., 2001.11.5)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

C(3)G

(Fellmeth et al., 2023, Nieken et al., 2023, Kursel et al., 2021, Palacios et al., 2021, Bhargava et al., 2020, Fellmeth and McKim, 2020, Láscarez-Lagunas et al., 2020, Rubin et al., 2020, Hughes et al., 2019, Singh et al., 2018, Cahoon et al., 2017, Rog et al., 2017, Gyuricza et al., 2016, Zhaunova et al., 2016, Da Ines and White, 2015, Kurdzo and Dawson, 2015, Rojas-Ríos et al., 2015, Obeso et al., 2014, Urban et al., 2014, Weng et al., 2014, Iovino et al., 2013, Leibfried et al., 2013, Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013, Yan and McKee, 2013, Anand and Kai, 2012, Morris and Spradling, 2012, Pek et al., 2012, Rincon-Arano et al., 2012, Senger et al., 2011, Fichelson et al., 2010, Janic et al., 2010, Lancaster et al., 2010, Lewandowski et al., 2010, Ong and Tan, 2010, Ong et al., 2010, Patil and Kai, 2010, Tastan et al., 2010, Wang et al., 2010, Joyce and McKim, 2009, Narbonne-Reveau and Lilly, 2009, Ozdowski et al., 2009, Peng and Karpen, 2009, Resnick et al., 2009, Benoit et al., 2008, Blumenstiel et al., 2008, Gause et al., 2008, Zhou and Bickel, 2008, Barbosa et al., 2007, Chen et al., 2007, Lake et al., 2007, Lim and Kai, 2007, Mukai et al., 2007, Parma et al., 2007, Jeffress et al., 2006, McCaffrey et al., 2006, Mehrotra and McKim, 2006, Mirouse et al., 2006, Page and Hawley, 2006, Sugimura and Lilly, 2006, Gong et al., 2005, Thomas et al., 2005, Heidmann et al., 2004, Mehrotra et al., 2004, Roper and Brown, 2004, Webber et al., 2004, Findley et al., 2003, Manheim and McKim, 2003, Staeva-Vieira et al., 2003, Manheim and McKim, 2002, Page et al., 2002, Huynh and St. Johnston, 2000, Santos, 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

C3G

(Narbonne-Reveau et al., 2006)

CG17604

(Chen et al., 2012, Zhang et al., 2010, Perkins et al., 2009, Brandt, 2006, Bogdanov et al., 2002, Bogdanov et al., 2002, Grishaeva et al., 2001)

c(3)G

(Winbush and Singh, 2021, Miller, 2020, Rust et al., 2020, Billmyre et al., 2019, Lake et al., 2019, Wang et al., 2019, Hughes et al., 2018, Vimal et al., 2018, Hemmer and Blumenstiel, 2016, John et al., 2016, Dobson et al., 2015, Hsu et al., 2015, Lake et al., 2015, Collins et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Hongay and Orr-Weaver, 2011, Joyce et al., 2011, Reis et al., 2011, Schrider et al., 2011, Chubykin, 2010, Joyce and McKim, 2010, Patil and Kai, 2010, Wasbrough et al., 2010, Anderson et al., 2009, Jiang et al., 2009, Peretz et al., 2009, Page et al., 2008, Smith et al., 2008, Jeffress et al., 2007, Khetani and Bickel, 2007, Page et al., 2007, Brandt, 2006, Mukai et al., 2006, Bhagat et al., 2004, Navarro et al., 2004, Jang et al., 2003, Bogdanov et al., 2002, Chubykin, 2001)

c(3)g

(Chen et al., 2007, Chen et al., 2007, Malmanche et al., 2007, Manheim and McKim, 2002)

c3G

(Matsubayashi and Yamamoto, 1998, Matsubayashi and Oguma, 1994, Miyamoto, 1992)

Name Synonyms

Crossover suppressor on 3 of Gowen

(Janic et al., 2010)

crossover suppressor in chromosome 3 of Gowen

(Lindsley and Zimm, 1992)

crossover suppressor on 3 of Gowan

(Mukai et al., 2006)

crossover suppressor on 3 of Gowen

(John et al., 2016, Ong and Tan, 2010, Page, 2007.6.13)

Secondary FlyBase IDs

FBgn0038362
FBgn0063641

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47765

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VF37

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VF37

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000246

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47765/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000246

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000246

FlyMine - An integrated database for Drosophila genomics

FBgn0000246

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17604

MARRVEL_MODEL - MARRVEL (model organism gene)

47765

Linkouts

BioGRID - A database of protein and genetic interactions.

70923

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000246

DroID - A comprehensive database of gene and protein interactions.

FBgn0000246

DRSC - Results frm RNAi screens

FBgn0000246

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

c(3)G_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000246

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000246

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17604

Flygut - An atlas of the Drosophila adult midgut

FBgn0000246

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (208)

The following external sites may use different assemblies or annotations than FlyBase.

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