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Gene Dmel\c(3)G

General Information
Symbol	Dmel\c(3)G	Species	D. melanogaster
Name	crossover suppressor on 3 of Gowen	Annotation symbol	CG17604
Feature type	protein_coding_gene	FlyBase ID	FBgn0000246
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	c3G
Genomic Location
Chromosome (arm)	3R	Recombination map	3-57.4
Cytogenetic map	89A5-89A5	Sequence location	3R:11,615,195..11,618,301 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene crossover suppressor on 3 of Gowen is referred to in FlyBase by the symbol Dmel\c(3)G (CG17604, FBgn0000246). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: reciprocal meiotic recombination. 17 alleles are reported. The phenotypes of these alleles are annotated with: meiotic anaphase I; meiotic metaphase I; meiotic cell cycle; polytene chromosome chromocenter; synaptonemal complex. It has 3 annotated transcripts and 3 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1632901_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of c(3)G. Gene sequence location is 3R:11615195..11618301.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	c(3)G: crossover suppressor in chromosome 3 of Gowen Eliminates meiotic crossing over in homozygous females. First-division nondisjunction and chromosome loss frequent (30% for X, 2, and 3; 20% for 4); second division normal; exceptions more frequent at 25 than at 19. Production of triploids and intersexes 300-500 times normal. Egg hatch very low. Synaptonemal complexes absent from oocytes (Meyer), and both duration of meiotic prophase and number of 16-cell cysts per germarium reduced in c(3)G/c(3)G females (Smith and King, 1969, Genetics 60: 335-51). Meiotic loss of ring chromosomes increased in c(3)G females (Sandler, 1961, Nat. Cancer Inst. Monogr. 18: 243-73). No meiotic effects in homozygous males. In c(3)G/+ females, both intergenic recombination (Hinton, 1966, Genetics 53: 157-64) and the subset of intragenic recombination accompanied by recombination of flanking markers (Carlson, 1972, Genet. Res. 19: 129-32) increased. Somatic pairing (Semjenov, 1979, Tsitologiya 21: 1353-55) and somatic crossing over (Le Clerc, 1946, Science 103: 553-54) normal in c(3)G homozygotes; however, reported to be deficient for one of two X-ray-induced reactions leading to mitotic exchange (Handle, 1974, Molec. Gen. Genet. 128: 233-39). Heterochromatic interchanges inducible in oocytes of homozygous females by X irradiation (Roberts, 1969, Genetics 47: 387-408; Wurgler, Graf, Ruch, Beck, and Steiner, 1978, Arch. Genet. 51: 217-42). Oocytes of homozygous females show increased sensitivity to X irradiation and lack the normally observed fractionation effect (Watson, 1969, Mutat. Res. 8: 91-100; 1972, Mutat. Res. 14: 299-307); Watson (1972) also reports increased sensitivity of c(3)G-bearing sperm from c(3)G/+ males to translocation induction. RK3. c(3)G68 Effects slightly more severe than in c(3)G. Meiotic recombination absent; first-division nondisjunction and loss high (40% for X, 2, and 3; 30% for 4). Low level of nondisjunction in second meiotic division. Oocytes of homozygous females lack synaptonemal complex (Carpenter). c(3)GOR28 Hypomorphic allele. Homozygous females show polarized reduction of recombination to 4.3% between y and f with greatest reduction distally. X-chromosome nondisjunction temperature sensitive; 16.7% at 25; reduced to 10.2% in oocytes exposed to 17 during metaphase I and anaphase I; no X-chromosome loss at either temperature. Synaptonemal complex reduced in quantity and abnormal in structure. c(3)GOR28/Df(3R)sbd105 females exhibit no recombination and 32% X-chromosome nondisjunction.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 89A5-89A5   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References 89A2-89A2     (Szauter, 1998)
Experimentally Determined Recombination Data
Location	3-57.4
Left of (cM)	Sb
Right of (cM)	cv-c
Notes	P{wB}1-1 maps 0.15cM to the right of c(3)G. (Szauter, 1998)
Gene Model & Products
Please see the GBrowse view of Dmel\c(3)G for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) c(3)G-RA FBtr0083194  NM_142233   2617   744 c(3)G-RB FBtr0083195  NM_169670   2594   744 c(3)G-RC FBtr0083196  NM_169671   2629   744
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein c(3)G-PA   FBpp0082648   85.8   744   6.12     NP_650490   AAF55223 c(3)G-PB   FBpp0082649   85.8   744   6.12     NP_732065   AAN13675 c(3)G-PC   FBpp0082650   85.8   744   6.12     NP_732066   AAN13676
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201348   AA246740   AA263891   AA264552   AA265010   AA390885   AA392239   AA392542   AA441261   AA538788   AA540184   AA695727   AA816415   AA816783   AA979021   AE014297 AAF55223   AE014297 AAN13675   AE014297 AAN13676   AI515957   AW941216   AY089639 AAL90377   AY129432 AAM76174   BG637835   BG638701   BI163442   BI172384   BI214661   BI214696   BI370113   BI372358   BI373588   BI376147   BI482830   BI485517   BP540793   BT044078   CO274129   CO317782   EC060570   EC089585   EC256205   GH944243   GH945486   GH946558   GH947974   GH948943   GH949055   GH951000   GH954046   GH954088   GH955564   GH956446   GH957190   GH957213   GH959301   GH959866   GH960488   GH962320   GH963465   GH966062   GH967012   GH968306   GH970087   GH970255   GH970914   GH974796   GH975036   GH975247   GH975459   GH976672   GH976748   GH977336   GH980437   GH980848   GH981910   GH982210   GH983387
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VF37 Q8SXH0 Q8MQK7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   pole plasm   (Fisher et al., 2012) Comment:maternally deposited organism   • pole plasm (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   fat body/gonad primordium   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   germline cell   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   oocyte   • synaptonemal complex (Iida and Lilly, 2004) adult stageoogenesis stage S1 -- S7   presumptive oocyte & oocyte   • chromosome (Manheim and McKim, 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female   ovary   (Iida and Lilly, 2004)
Additional Descriptive Data
	c(3)G protein is detected in a ribbon pattern along the length of meiotic chromosomes during pachytene in germarium region 2a of the ovary. Staining persists through stage 7 of oogenesis. (Manheim and McKim, 2003)
Marker for
	synaptonemal complex
Subcellular Localization (GO Cellular Component)
CV term Evidence References
synaptonemal complex inferred from direct assay (Page and Hawley, 2001, Manheim and McKim, 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    32.775 Larval Midgut    12.3 Larval Hindgut    10.4 Larval Malpighian Tubules    13 Larval Fat Body    13.6 Larval Salivary Gland    23.3 Larval Trachea    29.575 Larval Carcass    9.4 Adult Head    10.9 Adult Eye    13.525 Adult Brain    28.4 Adult Thoracic-Abdominal Ganglion    25.9 Adult Crop    19.3 Adult Midgut    12.5 Adult Hindgut    8.6 Adult Malpighian Tubules    11.6 Adult Fat Body    11.7 Adult Salivary Gland    16.8 Adult Heart    10.7 Adult VirginFemale Spermatheca    14 Adult InseminatedFemale Spermatheca    17.7 Adult Ovary    179.8 Adult Testis    27.4 Adult Male Accessory Gland    11.5 Adult Carcass    10 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    28.4   32.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.9   NA  Crop    19.3   no informative data  Midgut    no informative data   no informative data  Hindgut    8.6   13  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   23.3  Salivary Gland    no informative data   NA  Heart    no informative data   29.575  Trachea    NA   NA  VirginFemale Spermatheca    14   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    179.8   NA  Testis    27.4   NA  Male Accessory Gland    no informative data   9.4  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female  (52) ovary, mated 4-day female  (44) testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female  (52) ovary, mated 4-day female  (44) testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    6 central nervous system, larvae L3    4 central nervous system, pupae P8    4 head, virgin 1-day female    2 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    2 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    5 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    2 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    2 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    4 carcass, 20-day adult    3 ovary, virgin 4-day female    52 ovary, mated 4-day female    44 testis, mated 4-day male    2 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    26 embryo 04-06hr    9 embryo 06-08hr    6 embryo 08-10hr    10 embryo 10-12hr    5 embryo 12-14hr    12 embryo 14-16hr    3 embryo 16-18hr    6 embryo 18-20hr    3 embryo 20-22hr    9 embryo 22-24hr    13 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    4 adult female 05day    19 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167  (29) embryonic S1    12 embryonic S3  (34) leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167  29 embryonic S1    12 embryonic S3  (34) leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    9 Schneider line 2 Sg4    3 embryonic 1182-4H    3 embryonic GM2    8 embryonic Kc167    29 embryonic S1    12 embryonic S3    34 leg disc CME L1    4 wing disc CME-W2    14 wing disc ML-DmD8    4 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    1 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    10 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    6 ovary fGS/OSS    6 ovary OSC    8 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult  (40) Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    40 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • FI01435 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17604-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 c(3)GGD9424 Other Phenotypes Allele meiotic cell cycle defective c(3)Gunspecified meiotic cell cycle defective | female c(3)G1 c(3)G68 c(3)GOR28 meiotic cell cycle defective | recessive c(3)G68 wild-type c(3)G+tX203 Phenotype manifest in Allele germarium & nuclear chromosome c(3)G68 meiotic anaphase I c(3)Gunspecified meiotic cell cycle c(3)Gunspecified meiotic metaphase I c(3)Gunspecified nurse cell & nuclear chromosome c(3)G68 oocyte & meiosis & nuclear chromosome c(3)G68 polytene chromosome chromocenter c(3)Gunspecified synaptonemal complex c(3)G1 c(3)G68 c(3)GOR28 synaptonemal complex, with Scer\GAL4nos.UTR.T:Hsim\VP16, c(3)G68 c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG synaptonemal complex, with Scer\GAL4nos.UTR.T:Hsim\VP16, c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG c(3)G68 synaptonemal complex (with c(3)G68), with Scer\GAL4nos.UTR.T:Hsim\VP16 c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG synaptonemal complex (with c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG), with Scer\GAL4nos.UTR.T:Hsim\VP16 c(3)G68
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of c(3)G Class Mutagen Stocks Known lesion c(3)G1 spontaneous 2 Yes c(3)Gf05971 1 -- c(3)GG5001 P-element activity 1 -- c(3)G68 ethyl methanesulfonate 0 Yes c(3)GOR28 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- c(3)Gunspecified 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of c(3)G Class Mutagen Stocks Known lesion c(3)GGD9424 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes c(3)G+tX203 in vitro construct - genomic fragment 0 Yes c(3)GCC1del.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes c(3)GCdel.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes c(3)GCFLAG.Scer\UAS.P\T.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes c(3)GFL.Scer\UAS.P\T in vitro construct - regulatory fusion 0 Yes c(3)GNCdel.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes c(3)GNdel.Scer\UAS.P\T in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes c(3)GNIG.17604R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes c(3)GT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes c(3)GtX204 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)c(3)G-2 (Matsubayashi and Yamamoto, 1998, Nelson and Szauter, 1992, Thatcher and Szauter, 1995, Szauter, 1997) Df(3R)Exel6175 (Ryder, 2004.4.26) Df(3R)Exel7326 (Ryder, 2004.4.26) Df(3R)Po2 (Matsubayashi and Yamamoto, 1998, Nelson and Szauter, 1992) Df(3R)Po3 (Nelson and Szauter, 1992) Df(3R)Po4 (Nelson and Szauter, 1992) Df(3R)R24 (Matsubayashi and Yamamoto, 1998) Df(3R)R44 (Matsubayashi and Yamamoto, 1998) Df(3R)sbd105 (Nelson and Szauter, 1992)
Not disrupted in	Df(3R)160R5 (Matsubayashi and Yamamoto, 1998) Df(3R)160R8 (Matsubayashi and Yamamoto, 1998) Df(3R)160R32 (Matsubayashi and Yamamoto, 1998) Df(3R)160R34 (Matsubayashi and Yamamoto, 1998) Df(3R)160R104 (Matsubayashi and Yamamoto, 1998) Df(3R)167R11 (Matsubayashi and Yamamoto, 1998) Df(3R)167R17 (Matsubayashi and Yamamoto, 1998) Df(3R)167R37 (Matsubayashi and Yamamoto, 1998) Df(3R)sbd26 (Nelson and Szauter, 1992) Df(3R)sbd45 (Nelson and Szauter, 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9424} NA P{NIG.17604R} NA P{UASp-c(3)G.CC1del} NA P{UASp-c(3)G.Cdel} NA P{UASp-c(3)G.CFLAG} NA P{UASp-c(3)G.FL} NA P{UASp-c(3)G.NCdel} NA P{UASp-c(3)G.Ndel} NA characterization construct P{c(3)G-eGFP} NA P{X203} NA P{X204} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions 412{}c(3)G1 NA PBac{WH}c(3)Gf05971 NA insertion of mobile activating element P{EP}c(3)GG5001 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
synaptonemal complex inferred from direct assay (Page and Hawley, 2001, Manheim and McKim, 2002)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
reciprocal meiotic recombination traceable author statement (McKim et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions c(3)G allele Gene References c(3)G68 c(2)M (Manheim and McKim, 2003) c(3)Gunspecified okr (Ghabrial and Schupbach, 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70923 DroID - A comprehensive database of gene and protein interactions. • FBgn0000246 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47765
Orthologs
OrthoDB Orthologs (9) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VT6GR Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6VT6GR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\c(3)G     Drosophila simulans   Dsim\GD20329 Y   Drosophila sechellia   Dsec\GM25754 Y   Drosophila erecta   Dere\GG20388     Drosophila erecta   Dere\GG20377     Drosophila yakuba   Dyak\GE26360 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26705 Y   Drosophila persimilis   Dper\GL23692 Y   Drosophila willistoni   Dwil\GK10347 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20329 Drosophila sechellia Dsec\GM25754 Drosophila yakuba Dyak\GE26360 Drosophila pseudoobscura pseudoobscura Dpse\GA26705 Drosophila persimilis Dper\GL23692 Drosophila willistoni Dwil\GK10347 Drosophila virilis Dvir\GJ15351 Drosophila mojavensis Dmoj\GI14995 Drosophila grimshawi Dgri\GH12738
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	30110 w1118; P{EP}c(3)GG5001 606 sp2; st1 c(3)G1 ca1/TM1
Harvard	- PBac{WH}c(3)Gf05971
Kyoto	106004 sp2; st1 c(3)G1 ca1/TM1
VDRC	v32962 w1118; P{GD9424}v32962
Genomic Clones ( 2 )
	BACR06B08 BACR48G17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM04379 RE56519
Other clones	FI01435
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD01469 LD04313 LD05672 LD07177 LD07655 LD08634 LD09090 LD10345 LD11019 LD11442 LD16134 LD18391 LD19582 LD41674 RE02837 RE14849 RE20645 RE20696 RE59305 RE60918 RE64080 RE65596 RE68863
Other clones	12201 164555 214375.53 EK113256 EK269054 FGA008A01 LD33261 RP004004919 RP004063345 RP004063809 RP004077998 RP004094977 RP004119204 RP004119833 RP004163282 RP004189603 RP004190131 RP004202927 RP004211005 RP004219190 RP004223608 RP004227217 RP004229934 RP004237679 RP004240749 RP004242762 RP004295015 RP004311718 RP004313551 RP004342493 RP004347218 RP004351300 RP004355704 RP004420273 RP004429575 RP004433078 RP004456570 RP004473402 RP004483818 RP004514200 RP004526018 RP004545486 RP004550820
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47765
Antibody Information
	polyclonal antibody (Iida and Lilly, 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: c(3)G CG17604 (Page and Hawley, 2001)
Additional comments	"CG17604" may correspond to c(3)G, based on sequence of "CG17604" and mutant phenotype of c(3)G. (Grishaeva et al., 2001.11.5)
Other Comments
	c(3)G is involved in the maintenance of euchromatic sister chromatid cohesion as well as in the maintenance of homolog-homolog association. c(3)G oocytes show normal pairing in the heterochromatin. (Gong et al., 2005) c(3)G protein is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase in females, consistent with a role as a synaptonemal complex protein present on meiotic bivalents. (Page and Hawley, 2001) c(3)G is required for recombination and synaptonemal complex assembly. (Thatcher and Szauter, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142233 NM_169670 NM_169671 RefSeq (Proteins) • NP_650490 NP_732065 NP_732066 DDBJ / EMBL / GenBank • AA264552 AA695727 AAF55223 AAL90377 AAM76174 AAN13675 AAN13676 AW941216 AY089639 AY129432 BI370113 Entrez Gene - A searchable database of RefSeq genes. • 47765 UniProtKB/TrEMBL • Q8MQK7 Q8SXH0 Q9VF37
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI01435
Linkouts
	BioGRID - A database of protein and genetic interactions • 70923 DroID - A comprehensive database of gene and protein interactions. • FBgn0000246 DRSC - Results from RNAi screens. • FBgn0000246 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000246 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17604-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000246 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47765 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47765 modMine - Data generated by the modENCODE project. • FBgn0000246
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	c3G (Matsubayashi and Yamamoto, 1998, Matsubayashi and Oguma, 1994, Miyamoto, 1992) C3G (Narbonne-Reveau et al., 2006) C(3)G (Heidmann et al., 2004, Roper and Brown, 2004, Mehrotra et al., 2004, Staeva-Vieira et al., 2003, Manheim and McKim, 2003, Findley et al., 2003, Page et al., 2002, Manheim and McKim, 2002, Huynh and St. Johnston, 2000, Santos, 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Jeffress et al., 2006, Page and Hawley, 2006, McCaffrey et al., 2006, Thomas et al., 2005, Mirouse et al., 2006, Lim and Kai, 2007, Ong and Tan, 2010, Zhou and Bickel, 2008, Mukai et al., 2007, Sugimura and Lilly, 2006, Barbosa et al., 2007, Lake et al., 2007, Mehrotra and McKim, 2006, Benoit et al., 2008, Chen et al., 2007, Blumenstiel et al., 2008, Joyce and McKim, 2009, Gause et al., 2008, Anand and Kai, 2012, Narbonne-Reveau and Lilly, 2009, Peng and Karpen, 2009, Parma et al., 2007, Resnick et al., 2009, Webber et al., 2004, Gong et al., 2005, Lewandowski et al., 2010, Patil and Kai, 2010, Wang et al., 2010, Fichelson et al., 2010, Senger et al., 2011, Ozdowski et al., 2009, Morris and Spradling, 2012, Janic et al., 2010, Ong et al., 2010, Tastan et al., 2010, Lancaster et al., 2010, Leibfried et al., 2013, Rincon-Arano et al., 2012, Pek et al., 2012) c(3)g (Manheim and McKim, 2002, Malmanche et al., 2007, Chen et al., 2007, Chen et al., 2007) c(3)G (Mukai et al., 2006, Navarro et al., 2004, Smith et al., 2008, Page et al., 2008, Jeffress et al., 2007, Jiang et al., 2009, Jang et al., 2003, Khetani and Bickel, 2007, Anderson et al., 2009, Peretz et al., 2009, Page et al., 2007, Brandt, 2006, Wasbrough et al., 2010, Reis et al., 2011, Chubykin, 2001, Bogdanov et al., 2002, Chubykin, 2010, Japanese National Institute of Genetics, 2012.5.21) CG17604 (Grishaeva et al., 2001, Bogdanov et al., 2002, Brandt, 2006, Bogdanov et al., 2002) cx
Name Synonym	crossover suppressor in chromosome 3 of Gowen (Lindsley and Zimm, 1992) crossover suppressor on 3 of Gowan (Mukai et al., 2006) crossover suppressor on 3 of Gowen (Page, 2007.6.13, Ong and Tan, 2010) Crossover suppressor on 3 of Gowen (Janic et al., 2010)
Secondary FlyBase IDs
	FBgn0038362 FBgn0063641
References ( 148 )
Generate a list of	All references relating to this gene ( 148 )
List References by type	Research paper  ( 95 ) Supplementary material  ( 7 ) Review  ( 6 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 26 ) FlyBase analysis  ( 2 ) Stock list  ( 2 ) Book  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Leibfried et al., 2013, Development 140(2): 362--371 A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. [FBrf0220348] Anand and Kai, 2012, EMBO J. 31(4): 870--882 The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila. [FBrf0217541] Morris and Spradling, 2012, PLoS ONE 7(10): e46109 Steroid Signaling within Drosophila Ovarian Epithelial Cells Sex-Specifically Modulates Early Germ Cell Development and Meiotic Entry. [FBrf0219659] Pek et al., 2012, Development 139(24): 4505--4513 Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila. [FBrf0220058] Rincon-Arano et al., 2012, Cell 151(6): 1214--1228 UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions. [FBrf0220189] Reis et al., 2011, PLoS ONE 6(3): e17512 Drosophila Genes That Affect Meiosis Duration Are among the Meiosis Related Genes That Are More Often Found Duplicated. [FBrf0213266] Senger et al., 2011, Development 138(10): 2133--2142 The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. [FBrf0213566] Takeo et al., 2011, Curr. Biol. 21(21): 1845--1851 Synaptonemal complex-dependent centromeric clustering and the initiation of synapsis in Drosophila oocytes. [FBrf0216635] Tanneti et al., 2011, Curr. Biol. 21(21): 1852--1857 A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes. [FBrf0216648] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...