General Information
Symbol
Dmel\c(3)G
Species
D. melanogaster
Name
crossover suppressor on 3 of Gowen
Annotation Symbol
CG17604
Feature Type
FlyBase ID
FBgn0000246
Gene Model Status
Stock Availability
Gene Snapshot
crossover suppressor on 3 of Gowen (c(3)G) encodes the transerve filament protein of the synaptonemal complex. The product of c(3)G is required for many meiotic processes, including homolog pairing, recombination, and chromosome segregation at meiosis I. [Date last reviewed: 2018-09-06]
Also Known As
c3G
Genomic Location
Cytogenetic map
Sequence location
3R:15,789,473..15,792,579 [-]
Recombination map
3-58
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
Molecular Function (see GO section for details)
Experimental Evidence
-
Predictions / Assertions
-
Summaries
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
c(3)G: crossover suppressor in chromosome 3 of Gowen
Eliminates meiotic crossing over in homozygous females. First-division nondisjunction and chromosome loss frequent (30% for X, 2, and 3; 20% for 4); second division normal; exceptions more frequent at 25 than at 19. Production of triploids and intersexes 300-500 times normal. Egg hatch very low. Synaptonemal complexes absent from oocytes (Meyer), and both duration of meiotic prophase and number of 16-cell cysts per germarium reduced in c(3)G/c(3)G females (Smith and King, 1969, Genetics 60: 335-51). Meiotic loss of ring chromosomes increased in c(3)G females (Sandler, 1961, Nat. Cancer Inst. Monogr. 18: 243-73). No meiotic effects in homozygous males. In c(3)G/+ females, both intergenic recombination (Hinton, 1966, Genetics 53: 157-64) and the subset of intragenic recombination accompanied by recombination of flanking markers (Carlson, 1972, Genet. Res. 19: 129-32) increased. Somatic pairing (Semjenov, 1979, Tsitologiya 21: 1353-55) and somatic crossing over (Le Clerc, 1946, Science 103: 553-54) normal in c(3)G homozygotes; however, reported to be deficient for one of two X-ray-induced reactions leading to mitotic exchange (Handle, 1974, Molec. Gen. Genet. 128: 233-39). Heterochromatic interchanges inducible in oocytes of homozygous females by X irradiation (Roberts, 1969, Genetics 47: 387-408; Wurgler, Graf, Ruch, Beck, and Steiner, 1978, Arch. Genet. 51: 217-42). Oocytes of homozygous females show increased sensitivity to X irradiation and lack the normally observed fractionation effect (Watson, 1969, Mutat. Res. 8: 91-100; 1972, Mutat. Res. 14: 299-307); Watson (1972) also reports increased sensitivity of c(3)G-bearing sperm from c(3)G/+ males to translocation induction. RK3.
c(3)G68
Effects slightly more severe than in c(3)G. Meiotic recombination absent; first-division nondisjunction and loss high (40% for X, 2, and 3; 30% for 4). Low level of nondisjunction in second meiotic division. Oocytes of homozygous females lack synaptonemal complex (Carpenter).
c(3)GOR28
Hypomorphic allele. Homozygous females show polarized reduction of recombination to 4.3% between y and f with greatest reduction distally. X-chromosome nondisjunction temperature sensitive; 16.7% at 25; reduced to 10.2% in oocytes exposed to 17 during metaphase I and anaphase I; no X-chromosome loss at either temperature. Synaptonemal complex reduced in quantity and abnormal in structure. c(3)GOR28/Df(3R)sbd105 females exhibit no recombination and 32% X-chromosome nondisjunction.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\c(3)G or the JBrowse view of Dmel\c(3)G for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.41
Gene model reviewed during 5.47
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083194
2617
744
FBtr0083195
2594
744
FBtr0083196
2629
744
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0082648
85.8
744
6.12
FBpp0082649
85.8
744
6.12
FBpp0082650
85.8
744
6.12
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

744 aa isoforms: c(3)G-PA, c(3)G-PB, c(3)G-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\c(3)G using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
c(3)G protein is detected in a ribbon pattern along the length of meiotic chromosomes during pachytene in germarium region 2a of the ovary. Staining persists through stage 7 of oogenesis.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\c(3)G in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Allele of c(3)G
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Other relevant insertions
Transgenic Constructs ( 12 )
Deletions and Duplications ( 19 )
Summary of Phenotypes
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No orthologs reported.
Rattus norvegicus (Norway rat) (0)
No orthologs reported.
Xenopus tropicalis (Western clawed frog) (0)
No orthologs reported.
Danio rerio (Zebrafish) (0)
No orthologs reported.
Caenorhabditis elegans (Nematode, roundworm) (0)
No orthologs reported.
Arabidopsis thaliana (thale-cress) (10)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
No
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
Yes
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919042J )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Human Disease Model Data
FlyBase Human Disease Model Reports
    Alleles Reported to Model Human Disease (Disease Ontology)
    Download
    Models ( 0 )
    Allele
    Disease
    Evidence
    References
    Interactions ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Human Orthologs (via DIOPT v7.1)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-58
    Cytogenetic map
    Sequence location
    3R:15,789,473..15,792,579 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    89A5-89A5
    Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    89A2-89A2
    Experimentally Determined Recombination Data
    Location
    3-57.4
    Left of (cM)
    Right of (cM)
    Notes
    P{wB}1-1 maps 0.15cM to the right of c(3)G.
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (69)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    polyclonal antibody
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: c(3)G CG17604
    Additional comments
    "CG17604" may correspond to c(3)G, based on sequence of "CG17604" and mutant phenotype of c(3)G.
    Other Comments
    c(3)G is involved in the maintenance of euchromatic sister chromatid cohesion as well as in the maintenance of homolog-homolog association. c(3)G oocytes show normal pairing in the heterochromatin.
    c(3)G protein is present in a thread-like pattern along the lengths of chromosomes in meiotic prophase in females, consistent with a role as a synaptonemal complex protein present on meiotic bivalents.
    c(3)G is required for recombination and synaptonemal complex assembly.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 36 )
    Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Synonyms and Secondary IDs (11)
    Reported As
    Symbol Synonym
    cx
    Name Synonyms
    Crossover suppressor on 3 of Gowen
    crossover suppressor in chromosome 3 of Gowen
    crossover suppressor on 3 of Gowan
    crossover suppressor on 3 of Gowen
    Secondary FlyBase IDs
    • FBgn0038362
    • FBgn0063641
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (179)