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Gene Dmel\ca

General Information
Symbol	Dmel\ca	Species	D. melanogaster
Name	claret	Annotation symbol	CG31037
Feature type	protein_coding_gene	FlyBase ID	FBgn0000247
Gene Model Status	Current	Stock availability	461 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map	3-100.7
Cytogenetic map	99C2-99C2	Sequence location	3R:25,632,714..25,640,769 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene claret is referred to in FlyBase by the symbol Dmel\ca (CG31037, FBgn0000247). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Rab guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; Rab GTPase binding. There is experimental evidence that it is involved in the biological process: eye pigment granule organization; negative regulation of gene silencing by RNA; ommochrome biosynthetic process. 66 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; external compound sense organ; organ system; retinal pigment granule; region of integument; adult; peripheral nervous system; compound cell cluster organ; adult segment; nervous system; female genitalia. It has one annotated transcript and one annotated polypeptide. Protein features are: Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; Regulator of chromosome condensation, RCC1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629766_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ca. Gene sequence location is 3R:25632714..25640769.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ca: claret Eye color ruby. With cn, eye color is deep reddish yellow; with bw, translucent brownish yellow (Mainx, 1938, Z. Indukt. Abstamm. Vererbungsl. 75: 256-76). Larval Malpighian tubes colorless (Beadle, 1937, Genetics 22: 587-611). Eye color autonomous when larval optic disk from ca is transplanted into wild type or v. Wild-type disk in ca not entirely autonomous (Beadle and Ephrussi, 1936, Genetics 21: 230); ca flies produce less v+ substance than wild type (Clancy, 1942, Genetics 27: 417-40). Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal (Sullivan and Sullivan, 1975, Biochem. Genet. 13: 603-13). Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine, reported by Okubo (1958, Med. J. Osaka Univ. 9: 327-37). Slightly narrow body and pointed wing. RK1. cav: claret-variegated cav/ca slightly variegated. Can be confused with wild type. cav/cand1 females produce normal progeny. Homozygous lethal. RK3A.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms intracellular Rab guanyl-nucleotide exchange factor activity guanyl-nucleotide exchange factor activity Rab GTPase binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99C2-99C2   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99B8-99B10   (determined by in situ hybridisation)   (Yamamoto et al., 1989)
Experimentally Determined Recombination Data
Location	3-100.7 (Ives, 1949)
Left of (cM)	ld (Lewis, 1956)
Right of (cM)	mus308 mus307 mus306 (Boyd et al., 1981)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ca for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ca-RA FBtr0085484  NM_170430   6845   1961
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ca-PA   FBpp0084850   217.9   1961   5.48     NP_733309   AAF56945
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801521   AE014297 AAF56945   AI532603   AI533196   AW944392   AY069808 AAL39953   BF493135   BG639672   BI565915   BI570103   BI574772   BI575032   BI581363   BI582019   BI584560   BI612088   BI620715   BI627483   BT011349   BT057978   CK662211   CO189792   CO276849   CO277060   CO278620   CO320382   CO331014   CO331550   CO342976   CO343037   CZ479865   CZ479866   CZ479868   EC083129   EC090515   EC205049   EC210068   EC220550   EC227611   EC252369   EC258426
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VAG5 Q8T9D9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
intracellular inferred from direct assay (Ma et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult fat body, larval/adult salivary gland, adult ovary, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    200.35 Larval Midgut    114.5 Larval Hindgut    109 Larval Malpighian Tubules    101.4 Larval Fat Body    58.2 Larval Salivary Gland    129.3 Larval Trachea    59.45 Larval Carcass    121.325 Adult Head    88.1 Adult Eye    91.225 Adult Brain    185.6 Adult Thoracic-Abdominal Ganglion    174.4 Adult Crop    124.4 Adult Midgut    98.1 Adult Hindgut    105.4 Adult Malpighian Tubules    95.2 Adult Fat Body    131.5 Adult Salivary Gland    160.5 Adult Heart    76.275 Adult VirginFemale Spermatheca    64.1 Adult InseminatedFemale Spermatheca    58.1 Adult Ovary    198.9 Adult Testis    71 Adult Male Accessory Gland    99.4 Adult Carcass    126.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    88.1   NA  Eye    91.225   NA  Brain    185.6   200.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    174.4   NA  Crop    124.4   114.5  Midgut    98.1   109  Hindgut    105.4   101.4  Malpighian Tubules    95.2   58.2  Fat Body    131.5   129.3  Salivary Gland    160.5   NA  Heart    76.275   59.45  Trachea    NA   NA  VirginFemale Spermatheca    64.1   NA  InseminatedFemale Spermatheca    58.1   NA  Ovary    198.9   NA  Testis    71   NA  Male Accessory Gland    99.4   121.325  Carcass    126.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    16 central nervous system, larvae L3    16 central nervous system, pupae P8    14 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    11 head, mated 1-day female    8 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    13 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    5 fat body, pupae P8    5 carcass, larvae L3 wandering    10 carcass, 1-day adult    8 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    24 ovary, mated 4-day female    20 testis, mated 4-day male    10 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    12 embryo 10-12hr    9 embryo 12-14hr    11 embryo 14-16hr    12 embryo 16-18hr    10 embryo 18-20hr    11 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    10 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    8 white prepupae 12hr    10 white prepupae 24hr    13 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    10 adult male 01day    12 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    18 adult female 30day    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1  (28) embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1  28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    24 Schneider line 2 Sg4    10 embryonic 1182-4H    16 embryonic GM2    8 embryonic Kc167    5 embryonic S1    28 embryonic S3    10 leg disc CME L1    10 wing disc CME-W2    7 wing disc ML-DmD8    8 wing disc ML-DmD9    11 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    6 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    14 CNS ML-DmBG2-c2    12 tumorous blood cells mbn2    18 ovary fGS/OSS    18 ovary OSC    15 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    5 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    16 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000247 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31037-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 caGD8680 Sterility Allele female sterile | recessive ca89300-1 male sterile | recessive ca89300-1 Other Phenotypes Allele eye color defective ca1 ca2 ca3 ca4 ca5 ca6 ca7 ca8 ca9 ca10 ca11 ca12 ca13 ca14 ca15 ca16 ca17 ca18 ca19 ca20 ca22 ca23 ca24 ca25 ca26 ca27 ca28 ca29 ca30 ca31 ca32 ca33 ca34 ca35 ca36 ca89300-1 caAR caC28 caKN311 cand1 cand7 caunspecified eye color defective | recessive ca1 ca2 ca3 ca32 ca33 ca34 ca49c cand3 cand4 cand5 cand6 cand8 caR5 caR10 caR12 visible | recessive ca1 ca2 ca3 ca4 ca5 ca6 ca7 ca8 ca9 ca10 ca11 ca12 ca13 ca14 ca15 ca16 ca17 ca18 ca19 ca20 ca22 ca23 ca24 ca25 ca26 ca27 ca28 ca29 ca30 ca31 ca32 ca33 ca34 ca35 ca36 ca89300-1 caAR caKN311 caunspecified wild-type caR4 caR8 Phenotype manifest in Allele abdomen ca1 eye ca1 ca2 ca22 ca23 ca24 ca25 ca26 ca27 ca28 ca29 ca3 ca30 ca31 ca32 ca33 ca34 ca35 ca36 caKN311 caR10 caR12 caR5 cand5 cand6 cand7 cand8 caunspecified female genitalia ca89300-1 male genitalia ca89300-1 Malpighian tubule ca10 ca11 ca12 ca13 ca14 ca15 ca16 ca17 ca18 ca19 ca2 ca20 ca4 ca5 ca6 ca7 ca8 ca9 cand3 cand4 ocellus ca3 pigment cell ca1 ca10 ca11 ca12 ca13 ca14 ca15 ca16 ca17 ca18 ca19 ca2 ca20 ca22 ca23 ca24 ca25 ca26 ca27 ca28 ca29 ca3 ca30 ca31 ca32 ca33 ca34 ca35 ca36 ca4 ca49c ca5 ca6 ca7 ca8 ca89300-1 ca9 caAR caC28 caKN311 caR10 caR12 caR5 cand1 cand3 cand4 cand5 cand6 cand7 cand8 caunspecified primary pigment cell pigment granule ca1 secondary pigment cell pigment granule ca1 tertiary pigment cell pigment granule ca1 wing ca1 ca2
Classical Alleles ( 59 )
For All Classical Alleles Show
Allele of ca Class Mutagen Stocks Known lesion ca1 spontaneous 454 Yes cand1 X ray 5 Yes ca3 1 -- cae02047 piggyBac transposase 1 -- caG3829 P-element activity 1 -- ca10 gamma ray 0 -- ca11 gamma ray 0 -- ca12 gamma ray 0 -- ca13 gamma ray 0 -- ca14 gamma ray 0 -- ca15 gamma ray 0 -- ca16 hypomorphic allele - genetic evidence gamma ray 0 -- ca17 gamma ray 0 -- ca18 gamma ray 0 -- ca19 gamma ray 0 -- ca20 gamma ray 0 -- ca21 X ray 0 -- ca22 X ray 0 -- ca23 X ray 0 -- ca24 X ray 0 -- ca25 X ray 0 -- ca26 X ray 0 -- ca27 X ray 0 -- ca28 X ray 0 -- ca29 X ray 0 -- ca2 spontaneous 0 -- ca30 X ray 0 -- ca31 X ray 0 -- ca32 PM hybrid dysgenesis 0 Yes ca33 PM hybrid dysgenesis 0 Yes ca34 PM hybrid dysgenesis 0 Yes ca35 X ray 0 -- ca36 X ray 0 -- ca49c 0 -- ca4 gamma ray 0 -- ca56j spontaneous 0 -- ca5 gamma ray 0 -- ca6 gamma ray 0 -- ca7 gamma ray 0 -- ca89300-1 natural population 0 -- ca8 gamma ray 0 -- ca9 gamma ray 0 -- caAR ethyl methanesulfonate 0 -- caC28 natural population 0 -- cae02048 piggyBac transposase 0 -- cag gamma ray 0 -- caKN311 0 -- cand3 gamma ray 0 -- cand4 gamma ray 0 -- cand5 PM hybrid dysgenesis Js 0 Yes cand6 PM hybrid dysgenesis Js 0 Yes cand7 spontaneous 0 Yes cand8 PM hybrid dysgenesis 0 Yes caR10 spontaneous 0 Yes caR12 spontaneous 0 Yes caR4 spontaneous 0 Yes caR5 spontaneous 0 Yes caR8 spontaneous 0 Yes caunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ca Class Mutagen Stocks Known lesion caGD8680 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ca1-1132.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ca1-1273.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes caNIG.18133R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes caR6.9 in vitro construct - genomic fragment 0 Yes caScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes caX11.5 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;1)B152 (Frisardi and MacIntyre, 1984) Dp(3;1)H135   Dp(3;1)H163 (Harris, 1977) Dp(3;1)R87   Dp(3;Y)L127 (Frisardi and MacIntyre, 1984) Ts(Y;3Rt)Kpn+   Ts(YSt;3Rt)B226 (Jurgens and Weigel, 1988) Ts(YSt;3Rt)J116 (Jurgens and Weigel, 1988)
Disrupted in	Df(3R)BSC547 (Christensen et al., 2008.6.11) Df(3R)cand1 (Yamamoto et al., 1989) Df(3R)cand5 (Yamamoto et al., 1989) Df(3R)cand6 (Yamamoto et al., 1989) Df(3R)cand7 (Yamamoto et al., 1989) Df(3R)cand8 (Yamamoto et al., 1989) Df(3R)Ice (Xu et al., 2006) Df(3R)R61 (Mozer, 2001) Dp(3;1)1A (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)3 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)19 (Frisardi and MacIntyre, 1984) Dp(3;1)27 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)34 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)35 (Frisardi and MacIntyre, 1984) Dp(3;1)45B (Frisardi and MacIntyre, 1984) Dp(3;1)46A (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)48 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)52 (Frisardi and MacIntyre, 1984) Dp(3;1)67A (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)67N (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)74 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)78 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)79 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)88 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)93 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)97 (Frisardi and MacIntyre, 1984) Dp(3;1)124P (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)138P (Frisardi and MacIntyre, 1984) Dp(3;1)150P (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)152P (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)165P (Frisardi and MacIntyre, 1984) Dp(3;1)R10 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) Dp(3;1)R14 (Frisardi and MacIntyre, 1984, Kongsuwan et al., 1986) In(3R)ca-nd3 (Sequeira et al., 1989)
Not disrupted in	Df(3R)01215 (Cook, 2006.1.31) Df(3R)X3F (Cook, 2006.1.31) T(2;3)cand3 (Sequeira et al., 1989)
Not duplicated in	Dp(1;Y)su(f)+ (Gethmann, 1967) Dp(3;1)Dr-RXT11 (Jurgens and Weigel, 1988) Dp(3;1)O5 (Oliver, 1937)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8680} NA P{NIG.18133R} NA P{UAS-ca.1-1132} NA P{UAS-ca.1-1273} NA P{UAS-ca.HA} NA characterization construct P{ncd-ca.6.9} NA P{ncd-ca.11.5} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}ca34 NA PBac{RB}cae02047 NA PBac{RB}cae02048 NA insertion of mobile activating element P{EP}caG3829 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
guanyl-nucleotide exchange factor activity inferred from physical interaction with ltd (Ma et al., 2004) Rab GTPase binding inferred from physical interaction with ltd (Ma et al., 2004) Rab guanyl-nucleotide exchange factor activity inferred from physical interaction with ltd (Ma et al., 2004)
Biological Process
CV term Evidence References
eye pigment granule organization inferred from mutant phenotype (Ma et al., 2004) negative regulation of gene silencing by RNA inferred from mutant phenotype (Harris et al., 2011) ommochrome biosynthetic process inferred from mutant phenotype (Tearle, 1991)
Cellular Component
CV term Evidence References
intracellular inferred from direct assay (Ma et al., 2004)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
eye pigment precursor transport traceable author statement (Reaume et al., 1991)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ca allele Gene References ca1 cic (Ma et al., 2004) caunspecified w (Lloyd et al., 2002) unspecified bchs (Simonsen et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68382 DroID - A comprehensive database of gene and protein interactions. • FBgn0000247 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43518
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WSWVT Dipteran inclusive ortholog search EOG6B2T54 Insect inclusive ortholog search EOG6RXWV3 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG67X1F9
Orthologs in Drosophila Species (EOG6WSWVT)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ca     Drosophila simulans   Dsim\GD21470 Y   Drosophila sechellia   Dsec\GM12827 Y   Drosophila erecta   Dere\GG11698 Y   Drosophila yakuba   Dyak\GE23888 Y   Drosophila ananassae   Dana\GF18668 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27285 Y   Drosophila persimilis   Dper\GL23517 Y   Drosophila willistoni   Dwil\GK22629 Y   Drosophila virilis   Dvir\GJ24098 Y   Drosophila mojavensis   Dmoj\GI22045 Y   Drosophila grimshawi   Dgri\GH19978 Y
Orthologs in non-Drosophila Dipterans (EOG6B2T54)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006116   Anopheles gambiae Malaria mosquito  Agam\AGAP004229   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008458
Orthologs in non-Dipteran Insects (EOG6RXWV3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51512   Apis mellifera Western honey bee  Amel\LOC408321   Apis mellifera Western honey bee  Amel\GB43127   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012916   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH12840   Atta cephalotes Leafcutter ant  Acep\ACEP22021   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21670   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14173   Linepithema humile Argentine ant  Lhum\LH11321   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16298   Solenopsis invicta Red fire ant  Sinv\SINV20373   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000266   Bombyx mori Silkmoth  Bmor\BGIBMGA000415   Pediculus humanus Human body louse  Phum\PHUM047680   Tribolium castaneum Red flour beetle  Tcas\TC008540
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG67X1F9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\glo-4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000183gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002340gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21470 Drosophila sechellia Dsec\GM12827 Drosophila erecta Dere\GG11698 Drosophila yakuba Dyak\GE23888 Drosophila ananassae Dana\GF18668 Drosophila pseudoobscura pseudoobscura Dpse\GA27285 Drosophila persimilis Dper\GL23517 Drosophila willistoni Dwil\GK22629 Drosophila virilis Dvir\GJ24098 Drosophila mojavensis Dmoj\GI22045 Drosophila grimshawi Dgri\GH19978
Stocks & Reagents
Stocks Listed in FlyBase ( 461 )
Bloomington	459 ca1 1226 TM6C, ca1 461 ca1 awdK 465 cmp1 ca1/TM6 3115 spz2 ca1/TM1 27330 Qajjem211 ca1
Harvard	- PBac{RB}cae02047
Kyoto	105922 ca1 101585 ca3 / TM1 101584 ca1 awdK 105923 ca1 awdK 106855 spz2 ca1/TM1
	More stocks available...
Genomic Clones ( 2 )
	BACR02E15 BACR02O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 33 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH02355 SD04942
Other clones	FI02178
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01431 HL06521 LP22254 RH18747 RH19881 RH23803 RH27006 RH27591 RH34737 RH40483 RH51916 RH68818
Other clones	1159 1588 18487 179778 194368 214213.19 214277.2 273323 EK045201 EK122218 EK122813 EK130562 EK284526 EK297232 EK300514 EP15846 EP15960 SD04162
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000247 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43518
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: ca CG31037 (Ma et al., 2004)
Additional comments	Annotations CG18133, CG7799 and CG18134 merged as CG31037 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	Lesions in ca reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: ca is required for normal pigmentation of all four tissues. ca gene product may be a component of the ommochrome precursor transport system. (Tearle, 1991) The 'cand' locus has been found to be two closely linked but separate genes, ca and ncd. (Yamamoto et al., 1989) Pteridines (neodrosopterin, drosopterin, isodrosopterin, aurodrosopterin, 6-acetyl-dihydrohomopterin, sepiapterin, dihydrobiopterin, biopterin, pterin and isoxanthopterin) have been quantified in single and double mutants. (Silva and Mensua, 1985)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_170430 RefSeq (Proteins) • NP_733309 DDBJ / EMBL / GenBank • AAF56945 AAL39953 AI533196 AW944392 AY069808 BI570103 CZ479865 CZ479866 CZ479868 Entrez Gene - A searchable database of RefSeq genes. • 43518 UniProtKB/TrEMBL • Q8T9D9 Q9VAG5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Regulator of chromosome condensation, RCC1 (IPR000408) Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68382 DroID - A comprehensive database of gene and protein interactions. • FBgn0000247 DRSC - Results from RNAi screens. • FBgn0000247 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000247 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31037-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000247 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43518 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43518 modMine - Data generated by the modENCODE project. • FBgn0000247
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	bwG   bw-p   ca (Harris et al., 2011, Christensen et al., 2008.6.11, Whitlock and Bourguet, 2000, Hallen et al., 2008, Takahashi and Ting, 2004, Anaka et al., 2008, Wright, 1987, Cheli et al., 2010, Cherry and Perrimon, 2004, Japanese National Institute of Genetics, 2012.5.21) CG7799   CG18133   CG18134   CG31037 (Ma et al., 2004, Giot et al., 2003, )
Name Synonym	claret (Harris et al., 2011, Simonsen et al., 2007, Whitlock and Bourguet, 2000, Takahashi and Ting, 2004, Anaka et al., 2008, Wright, 1987, Cherry and Perrimon, 2004, Yoshimura et al., 2010, Maclellan et al., 2012) Claret (Cheli et al., 2010)
Secondary FlyBase IDs
	FBgn0039699 FBgn0039700 FBgn0039701 FBgn0051037
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 81 ) Supplementary material  ( 3 ) Review  ( 8 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Book  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Ferguson et al., 2012, J. Cell Sci. 125(6): 1407--1419 Modulation of gurken translation by insulin and TOR signaling in Drosophila. [FBrf0218097] Maclellan et al., 2012, Heredity 108(3): 203--210 Dietary stress does not strengthen selection against single deleterious mutations in Drosophila melanogaster. [FBrf0217530] Harris et al., 2011, J. Cell Biol. 194(1): 77--87 Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing. [FBrf0214287] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...