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Gene Dmel\capu

General Information
Symbol	Dmel\capu	Species	D. melanogaster
Name	cappuccino	Annotation symbol	CG3399
Feature type	protein_coding_gene	FlyBase ID	FBgn0000256
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	capp
Genomic Location
Chromosome (arm)	2L	Recombination map	2-8
Cytogenetic map	24C8-24C9	Sequence location	2L:3,872,646..3,902,860 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cappuccino is referred to in FlyBase by the symbol Dmel\capu (CG3399, FBgn0000256). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule binding. There is experimental evidence that it is involved in the biological process: chorion-containing eggshell formation; actin filament-based process; actin nucleation; pole plasm assembly; actin filament organization; pole plasm RNA localization. 38 alleles are reported. The phenotypes of these alleles are annotated with: female germline cyst; organ system; multicellular structure; anatomical structure; egg; gamete; embryonic abdomen; blastoderm embryo; protein complex; cell part. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Actin-binding FH2; Actin-binding FH2/DRF autoregulatory; Formin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult fat body, adult spermathecae. Comments on Affy2 ProbeSet: ProbeSet 1637398_a_at completely aligns to an exonic region common to each of the 9 FlyBase-annotated transcript isoforms of capu. Gene sequence location is 2L:3872646..3902860.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	capu: cappucino (T. Schupbach) Maternal-effect lethal. Homozygous females lay eggs which sometimes (5-10%) have a "pointed cap" (cappucino) of dorsal appendage material sitting over the anterior end of the egg, instead of two distinct dorsal appendages. Such eggs are similar to eggs formed by the female-sterile mutation fs(1)K10 but the extent of dorsal appendage material on capu eggs is much more variable than that of fs(1)K10 eggs. No polar granules are found in such eggs. Mutant females produce embryos lacking polar granules, pole cells, and normal abdominal segmentation. In combination with Bic-D, however, abdominal segmentation does develop in the anterior half of the embryo. Improper localization of abdominal determinants also indicated by the lack of posterior localization of vasa protein. Cellularization of the blastoderm irregularly defective, with nuclei of different sizes and densities. Resemble embryos formed by other grandchildless-knirps-like mutations, such as vasa or tudor, but in addition, some of the embryos from capu also appear dorsalized. Mosaic studies demonstrate germ-line function of capu.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24C8-24C9   Limits computationally determined from genome sequence between P{EP}EP2595EP2595 and P{lacW}edk01102
Experimentally Determined Cytological Location
Cytogenetic map Notes References 24D1-24D2     (Manseau, 1995.8.17)   capu lies proximal to a P{w+} insertion at 24D1--24D2.   (Emmons et al., 1995)
Experimentally Determined Recombination Data
Location	2-8 (Manseau and Schupbach, 1989)
Left of (cM)
Right of (cM)
Notes	Mapped using capu1. (Manseau and Schupbach, 1989)
Gene Model & Products
Please see the GBrowse view of Dmel\capu for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) capu-RA FBtr0077513  NM_057618   3861   1059 capu-RB FBtr0077512  NM_164567   3629   1049 capu-RD FBtr0077511  NM_164566   4305   1207 capu-RE FBtr0290077  NM_001144311   4294   1280 capu-RF FBtr0290078  NM_001144312   4537   1361 capu-RG FBtr0290079  NM_001144313   3059   932 capu-RH FBtr0290080  NM_001144314   3713   1107 capu-RI FBtr0290081  NM_001144315   4286   1298 capu-RJ FBtr0290082  NM_164565   3721   1089
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Emmons et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein capu-PA   FBpp0077202   113.9   1059   6.04     NP_476966   AAF51054 capu-PB   FBpp0077201   114.0   1049   6.57     NP_722952   AAN10367 capu-PD   FBpp0077200   131.0   1207   6.63     NP_722951   AAF51053 capu-PE   FBpp0288516   137.5   1280   5.86     NP_001137783   ACL82990 capu-PF   FBpp0288517   147.1   1361   6.06     NP_001137784   ACL82991 capu-PG   FBpp0288518   102.9   932   6.52     NP_001137785   ACL82992 capu-PH   FBpp0288519   120.7   1107   6.64     NP_001137786   ACL82993 capu-PI   FBpp0288520   141.0   1298   6.38     NP_001137787   ACL82994 capu-PJ   FBpp0288521   117.4   1089   6.00     NP_722950   AAN10366
Additional Polypeptide Data & Comments
Reported size (kDa)	1058 (aa); 114 (kD predicted) (Emmons et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Formin (IPR001265) Actin-binding FH2/DRF autoregulatory (IPR003104) Actin-binding FH2 (IPR015425)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51053   AE014134 AAF51054   AE014134 AAN10366   AE014134 AAN10367   AC004781   AC005732   AE014134 ACL82990   AE014134 ACL82991   AE014134 ACL82992   AE014134 ACL82993   AE014134 ACL82994   AI108555   AI238426   AI292573   AI405975   AI543107   AI944889   AI945161   AI945567   AI945797   AW940269   AY119486 AAM50140   BE977192   BF486531   BF486692   BF487253   BF487441   BF488124   BF488523   BF490464   BF493656   BF493750   BF494043   BF496264   BF497338   BF500192   BF500754   BF501106   BF501332   BF502109   BF502523   BF502905   BF503589   BF503645   BF504085   BF505997   BG632819   BG634747   BG636734   BI564755   BI565843   BP559474   BP559475   BP559987   BP559988   BT021476 AAX33624   BT024458   BT099599   BT099743   CL844496   CL943561   CO153133   CO153163   CO154698   CO190533   CO306796   CO308970   CO321602   CO335803   CO336999   CO337183   CO337685   CO344473   CZ468511   CZ474298   CZ477344   CZ477411   CZ478876   CZ484773   EC066313   EC077121   EC203684   EC246340   EC257473   EC260831   EC261500   EC262467   EC262667   EC266505   EC267736   GH952866   GH962440   U34258 AAC46925
UniProtKB/Swiss-Prot	Q24120
UniProtKB/TrEMBL	Q8IQ12 Q8MRP5 Q9VQV9 B7Z013 B7Z011 B7Z014 B7Z010 B7Z012 Q5BHU8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal apodeme   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17     (Emmons et al., 1995) Comment:reference states 0-24 hr AEL third instar larval stage     (Emmons et al., 1995) adult stage | female     (Emmons et al., 1995) ovary   (Emmons et al., 1995) adult stage | male     (Emmons et al., 1995) oogenesis   germarium region 2a & germarium region 2b & germarium region 3   (Emmons et al., 1995) oogenesis stage S1 -- S13   nurse cell   (Emmons et al., 1995) oogenesis stage S4 -- S9   oocyte   (Emmons et al., 1995) oogenesis stage S4 -- S11   follicle cell   (Emmons et al., 1995)
Additional Descriptive Data
	capu transcripts are detected as early as germarium stage 2 in the ovary. They are present in nurse cells in stage S1-S13 egg chambers. They are also detected in the oocyte nucleus from stage S4 to S9 and weakly in follicle cells from stage S4 to S11. On northern blots, capu transcripts are detected throughout embryogenesis, are absent in 1st and 2nd instars, and reappear in third instar larvae. They are also found in ovaries, in ovarectomized females, and in males. (Emmons et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (Rosales-Nieves et al., 2006) cytoplasm inferred from direct assay (Rosales-Nieves et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult fat body, adult spermathecae. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis    1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis  (1031.8) Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis  1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis    1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis    1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis  (1031.8) Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis  1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    66.7 Larval Midgut    213.3 Larval Hindgut    182.1 Larval Malpighian Tubules    62.7 Larval Fat Body    108.8 Larval Salivary Gland    6.6 Larval Trachea    36.7 Larval Carcass    41.05 Adult Head    82.6 Adult Eye    142.275 Adult Brain    224.9 Adult Thoracic-Abdominal Ganglion    234.7 Adult Crop    42.8 Adult Midgut    306.4 Adult Hindgut    259.8 Adult Malpighian Tubules    40.3 Adult Fat Body    160.7 Adult Salivary Gland    21 Adult Heart    79.2 Adult VirginFemale Spermatheca    116.4 Adult InseminatedFemale Spermatheca    103.2 Adult Ovary    88.4 Adult Testis    1031.8 Adult Male Accessory Gland    70.2 Adult Carcass    73.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    82.6   NA  Eye    142.275   NA  Brain    224.9   66.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    234.7   NA  Crop    42.8   213.3  Midgut    306.4   182.1  Hindgut    259.8   62.7  Malpighian Tubules    40.3   108.8  Fat Body    160.7   6.6  Salivary Gland    no informative data   NA  Heart    79.2   36.7  Trachea    NA   NA  VirginFemale Spermatheca    116.4   NA  InseminatedFemale Spermatheca    103.2   NA  Ovary    88.4   NA  Testis    1031.8   NA  Male Accessory Gland    70.2   41.05  Carcass    73.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male  (72) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (33) central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male  (72) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    33 central nervous system, larvae L3    4 central nervous system, pupae P8    8 head, virgin 1-day female    7 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    9 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    11 digestive system, 4-day adult    10 digestive system, 20-day adult    11 fat body, larvae L3 wandering    4 fat body, white prepupae    8 fat body, pupae P8    17 carcass, larvae L3 wandering    6 carcass, 1-day adult    3 carcass, 4-day adult    3 carcass, 20-day adult    4 ovary, virgin 4-day female    8 ovary, mated 4-day female    6 testis, mated 4-day male    72 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr  (29) pupae 2d postWPP  (28) pupae 3d postWPP    24 pupae 4d postWPP  (28) adult male 01day  (43) adult male 05day  (56) adult male 30day  (55) adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr  29 pupae 2d postWPP  28 pupae 3d postWPP    24 pupae 4d postWPP  28 adult male 01day  (43) adult male 05day  (56) adult male 30day  (55) adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    10 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    13 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    8 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    3 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    14 white prepupae new    12 white prepupae 12hr    21 white prepupae 24hr    29 pupae 2d postWPP    28 pupae 3d postWPP    24 pupae 4d postWPP    28 adult male 01day    43 adult male 05day    56 adult male 30day    55 adult female 01day    8 adult female 05day    7 adult female 30day    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (40) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2  (40) ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    4 embryonic 1182-4H    3 embryonic GM2    6 embryonic Kc167    0 embryonic S1    11 embryonic S3    2 leg disc CME L1    5 wing disc CME-W2    4 wing disc ML-DmD8    5 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    16 wing disc ML-DmD21    7 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    7 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    40 ovary fGS/OSS    2 ovary OSC    2 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    6 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • CG3399 GH07742 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000256 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3399-RC FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for capu Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | dorsal/ventral axis specification defective | embryonic stage | maternal effect | recessive capu1 lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive capu2L-7-13 capu2L-91-5 capu2L-192-35 capu2L-281-6 lethal | maternal effect | recessive capu1 capu2 capuHK3 viable capu3G3-1 capuEY12344 capuEY13172 viable, with Scer\GAL4pnr-MD237 capuGD879 Sterility Allele female sterile capu1 capu3G3-1 capuHK3 capuHK38 female sterile | recessive capu1 fertile capuEY12344 capuEY13172 Phenotype manifest in Allele blastoderm embryo | maternal effect capu1 capu2 capuHK3 chorion capu1 capu2 chorion | maternal effect capu1 capu2 capuHK3 dorsal appendage capu1 capu2 capu2F capuHK3 capuHK38 dorsal appendage | maternal effect capu1 capu2 capuHK3 egg | maternal effect capu1 capu2 capuHK3 egg | maternal effect (with capu1) capu2L-281-6 egg | maternal effect (with capu2L-281-6) capu1 egg chamber capu1 capu2 egg chamber | maternal effect capu1 capu2 capuHK3 embryo | germline clone | maternal effect | posterior capu2L-192-35 capu2L-281-6 capu2L-7-13 capu2L-91-5 embryo | maternal effect capu1 capu2 capuHK3 embryonic abdomen | maternal effect capu1 capu2 capuHK3 embryonic abdominal segment capu1 capu2 capuHK3 capuHK38 embryonic abdominal segment | maternal effect capu1 filamentous actin | oogenesis stage S9 capu2F filamentous actin | oogenesis stage S9 (with Df(2L)ed1) capu2 follicle cell | maternal effect capu1 capu2 capuHK3 microtubule capu1 capu2 capu2F capuEE nurse cell ring canal capu1 capu2 nurse follicle cell capu2 oocyte | oogenesis stage S9 capu2F oocyte | oogenesis stage S9 (with Df(2L)ed1) capu2 oocyte nucleus capu1 pole cell capu1 capuHK3 capuHK38 pole cell | maternal effect capu1 capu2 capuHK3 pole granule capu1 capuHK3 capuHK38 pole granule | maternal effect capu1 stage S8 oocyte capuEE
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of capu Class Mutagen Stocks Known lesion capu1 ethyl methanesulfonate 2 Yes capuf02268 piggyBac transposase 2 -- capu2 gain of function allele ethyl methanesulfonate 1 Yes capuc03227 piggyBac transposase 1 -- capud05064 P-element activity 1 -- capud10743 P-element activity 1 -- capue01050 piggyBac transposase 1 -- capue04209 1 -- capuEE 1 Yes capuEY12344 P-element activity 1 Yes capuEY13172 P-element activity 1 -- capuMI02297 1 -- capuMI05737 1 -- capu2F 0 Yes capu2L-192-35 ethyl methanesulfonate 0 -- capu2L-281-6 ethyl methanesulfonate 0 -- capu2L-7-13 ethyl methanesulfonate 0 -- capu2L-91-5 ethyl methanesulfonate 0 -- capu3871 0 Yes capu38 0 Yes capu3 ethyl methanesulfonate 0 -- capu3G3-1 ethyl methanesulfonate 0 Yes capu4 ethyl methanesulfonate 0 -- capu7L ethyl methanesulfonate 0 Yes capud10608 P-element activity 0 -- capuHK38 ethyl methanesulfonate 0 -- capuHK3 ethyl methanesulfonate 0 Yes capuM732 0 -- capuMB00531 0 -- capuunspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of capu Class Mutagen Stocks Known lesion capuScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes capuGD879 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes capuHMS00712 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes capuotu.PW in vitro construct - regulatory fusion 1 Yes capuKK101400 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes capuScer\UAS.P\T.cDa.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes capuScer\UAS.P\T.cDa in vitro construct - regulatory fusion 0 Yes capuΔN.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ed1 (Manseau and Schupbach, 1989, Wang and Lehmann, 1991, Schupbach and Wieschaus, 1991, de Belle et al., 1993) Df(2L)ed-dp (Schupbach and Wieschaus, 1991, de Belle et al., 1993) Df(2L)sc19-8 (de Belle et al., 1993)
Not disrupted in	Df(2L)M24F11 (de Belle et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD879} NA P{KK101400} NA P{TRiP.HMS00712} NA P{UASp-capu.D} NA P{UASp-capu.GFP.D} NA P{UASp-capu.GFP.ΔN} NA P{UASp-capu.GFP} NA characterization construct P{otu-capu.W} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}capuEY12344 NA P{EPgy2}capuEY13172 NA P{XP}capud05064 NA P{XP}capud10608 NA P{XP}capud10743 NA miscellaneous insertions Juan{}capu3G3-1 NA Mi{MIC}capuMI02297 NA Mi{MIC}capuMI05737 NA PBac{PB}capuc03227 NA PBac{RB}capue01050 NA PBac{RB}capue04209 NA PBac{WH}capuf02268 NA insertion of enhancer trap binary system Mi{ET1}capuMB00531 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from mutant phenotype (Rosales-Nieves et al., 2006)
Biological Process
CV term Evidence References
actin filament-based process inferred from direct assay (Rosales-Nieves et al., 2006) actin filament organization inferred from mutant phenotype (Dahlgaard et al., 2007) actin nucleation inferred from direct assay (Rosales-Nieves et al., 2006) chorion-containing eggshell formation inferred from mutant phenotype (Schupbach and Wieschaus, 1991) pole plasm assembly inferred from mutant phenotype (Raff et al., 1990, Schupbach and Wieschaus, 1991) pole plasm RNA localization inferred from mutant phenotype (Raff et al., 1990)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Rosales-Nieves et al., 2006) cytoplasm inferred from direct assay (Rosales-Nieves et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR001265, InterPro:IPR003104 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
oogenesis traceable author statement (Wylie, 1999) pole plasm assembly non-traceable author statement (FlyBase, 1992-, Williamson and Lehmann, 1996) traceable author statement (Wilsch-Brauninger et al., 1997, Mahowald, 2001) pole plasm oskar mRNA localization traceable author statement (Johnstone and Lasko, 2001)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR001265 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
capu - AP-2μ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG14695 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG16940 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG2972 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG5726 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - CG9684 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Gnf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Ns2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - SmG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - homer anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - l(3)72Ab anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - mRpL21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - mon2 anti tag coimmunoprecipitation, anti tag western blot (Tanaka et al., 2011) capu - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - pav anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) capu - tum anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions capu allele Gene References capu1 ct (Jackson and Berg, 1999) Ets97D (Gajewski and Schulz, 1995) Rho1 (Magie et al., 1999) capu2 chic (Manseau et al., 1996) ct (Jackson and Berg, 1999) nos (Wang and Lehmann, 1991) Rho1 (Magie et al., 1999) capu2F chic (Manseau et al., 1996) capuHK3 ct (Jackson and Berg, 1999) Ets97D (Gajewski and Schulz, 1995) unspecified chi (Manseau et al., 1996) Egfr (Manseau and Schupbach, 1989) grk (Manseau and Schupbach, 1989) mael (Bryant et al., 1997, Clegg et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59814 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000256 DroID - A comprehensive database of gene and protein interactions. • FBgn0000256 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33611
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B5PR3 Dipteran inclusive ortholog search EOG67WNX7 Insect inclusive ortholog search EOG6K997W Arthropod inclusive ortholog search EOG67H45Q Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6B5PR3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\capu     Drosophila simulans   Dsim\GD22724 Y   Drosophila sechellia   Dsec\GM18116 Y   Drosophila erecta   Dere\GG24397 Y   Drosophila yakuba   Dyak\GE14785 Y   Drosophila ananassae   Dana\GF24632 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25909 Y   Drosophila persimilis   Dper\GL19302 Y   Drosophila willistoni   Dwil\GK23771 Y   Drosophila virilis   Dvir\GJ17267 Y   Drosophila mojavensis   Dmoj\GI15288 Y   Drosophila grimshawi   Dgri\GH10237 Y
Orthologs in non-Drosophila Dipterans (EOG67WNX7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003162   Anopheles gambiae Malaria mosquito  Agam\AGAP010183   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003134
Orthologs in non-Dipteran Insects (EOG6K997W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44119   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022638   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022639   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16744   Atta cephalotes Leafcutter ant  Acep\ACEP11100   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17118   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15276   Linepithema humile Argentine ant  Lhum\LH17521   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13295   Solenopsis invicta Red fire ant  Sinv\SINV14919   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000839   Bombyx mori Silkmoth  Bmor\BGIBMGA010336   Pediculus humanus Human body louse  Phum\PHUM602670   Tribolium castaneum Red flour beetle  Tcas\capu
Orthologs in non-Insect Arthropods (EOG67H45Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_196142   Ixodes scapularis Deer tick  Isca\ISCW015518
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22724 Drosophila sechellia Dsec\GM18116 Drosophila erecta Dere\GG24397 Drosophila yakuba Dyak\GE14785 Drosophila ananassae Dana\GF24632 Drosophila pseudoobscura pseudoobscura Dpse\GA25909 Drosophila persimilis Dper\GL19302 Drosophila willistoni Dwil\GK23771 Drosophila virilis Dvir\GJ17267 Drosophila mojavensis Dmoj\GI15288 Drosophila grimshawi Dgri\GH10237
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	24763 P{UASp-capu.GFP}10, w* 24764 w*; P{UASp-capu.GFP}20 8799 capu2 cn1 bw1/CyO 8788 capuEE cn1 bw1/CyO 18533 w1118; PBac{WH}capuf02268/CyO
Harvard	- P{XP}capud05064 - P{XP}capud10743 - PBac{PB}capuc03227 - PBac{RB}capue01050 - PBac{RB}capue04209 - PBac{WH}capuf02268
VDRC	v34278 w1118; P{GD879}v34278
	More stocks available...
Genomic Clones ( 2 )
	BACR06H02 BACR22M14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04667 AT18380 AT20113 GH07742 LP14792
Other clones	DPiM_GH07742
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01976 AT02087 AT02451 AT04815 AT05370 AT08343 AT10026 AT11489 AT14943 AT15775 AT16330 AT16622 AT17741 AT18757 AT20857 AT21180 AT21985 AT22239 AT23222 AT23911 AT26937 AT31062 GH15509 GH26143 RH62257 RH63670 SD09708 SD14512
Other clones	61018 150070 542748 569531 bs06f04 bs09f08 bs14c11 bs17a03 bs60g10 EK048503 EK186014 EK252418 EK259815 EN01339 EN01412 EN04624 EN11238 EN13631 EN14008 EN15064 EP19337 FGM321B08 FGM324A06 GH14467 RP004138379 RP004525424
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000256 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33611
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: capu CG15420 (FlyBase, 1996-)
Additional comments	Source for merge of capu CG15420 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) The chic mutant phenotype resembles that caused by disrupting the actin cytoskeleton with cytochalasin D, and that of capu and spir. Mutants in chic resemble those in capu in that they fail to localize stau protein and osk mRNA to the posterior pole of the developing oocyte. (Manseau et al., 1996) The chic profilin product can bind to the product of capu in a yeast two hybrid assay. (Manseau et al., 1996) Analysis of capu mutant oocytes suggests that the microtubule cytoskeleton is misregulated resulting in premature microtubule bundling at the cortex of the oocyte and premature microtubule-dependent cytoplasmic streaming within the oocyte. Induction of premature microtubule based streaming in wild type embryos does not sweep away all previously localised molecular determinants, in support of the suggestion that the premature streaming alone cannot explain all of the patterning defects. (Emmons et al., 1995) capu and spir are not required for the synthesis or nuclear localisation of fs(1)K10 protein and they mediate dorsoventral patterning independently of fs(1)K10 mRNA localisation. (Serano and Cohen, 1995) Only vas and tud are essential for osk-induced pole cell and abdomen formation, capu is not. (Ephrussi and Lehmann, 1992) vas, vls and tud (but not stau, capu, or spir) are necessary for the 6xosk mutant phenotypes. (Smith et al., 1992) The posterior signal can be active at the anterior independent of capu function. (Lehmann and Nusslein-Volhard, 1991) capu mutant embryos exhibit an absence of posterior pole plasm, polar granules and pole cells. BicD,capu embryos exhibit a duplication of the posterior telson at the anterior. (Lehmann and Nusslein-Volhard, 1991) capu is required specifically for the localization, not the synthesis, of the posterior signal. (Lehmann and Nusslein-Volhard, 1991) Mutations in maternal dorsal class gene capu do not interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) Mutations at the capu locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991) capu gene function affects dorsoventral and anteroposterior patterning. (Lasko and Ashburner, 1990) capu plays a role in polar granule formation. (Raff et al., 1990) Mutations in grk and Egfr are epistatic to mutations in capu and spir. (Manseau and Schupbach, 1989) capu and spir participate in pattern formation in both the dorsoventral and anteroposterior axes of the embryo. Mosaic analysis reveals that the products of both are required in the oocyte-nurse cell complex. (Manseau and Schupbach, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057618 NM_164565 NM_164566 NM_164567 NM_001144311 NM_001144312 NM_001144313 NM_001144314 NM_001144315 RefSeq (Proteins) • NP_476966 NP_722950 NP_722951 NP_722952 NP_001137783 NP_001137784 NP_001137785 NP_001137786 NP_001137787 DDBJ / EMBL / GenBank • AAC46925 AAF51053 AAF51054 AAM50140 AAN10366 AAN10367 AAX33624 AC004781 AC005732 ACL82990 ACL82991 ACL82992 ACL82993 ACL82994 AI108555 AI405975 AI944889 AI945161 AI945567 AI945797 AW940269 AY119486 BF502523 BF503589 BT021476 CL844496 CL943561 CZ468511 CZ474298 CZ477344 CZ477411 CZ478876 CZ484773 U34258 Entrez Gene - A searchable database of RefSeq genes. • 33611 UniProtKB/Swiss-Prot • Q24120 UniProtKB/TrEMBL • B7Z010 B7Z011 B7Z012 B7Z013 B7Z014 Q5BHU8 Q8IQ12 Q8MRP5 Q9VQV9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Formin (IPR001265) Actin-binding FH2/DRF autoregulatory (IPR003104) Actin-binding FH2 (IPR015425) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG3399 GH07742
Linkouts
	BioGRID - A database of protein and genetic interactions • 59814 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000256 DroID - A comprehensive database of gene and protein interactions. • FBgn0000256 DRSC - Results from RNAi screens. • FBgn0000256 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000256 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3399-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000256 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33611 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cappuccino.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33611 modMine - Data generated by the modENCODE project. • FBgn0000256
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	capp (Jongens et al., 1992, Pawson et al., 2008) Capu (Keller et al., 2002, Anholt and Williams, 2010, Tanaka et al., 2011) capu (Wang and Riechmann, 2007, Neuman-Silberberg, 2007, Bakal et al., 2007, Wang and Riechmann, 2008, Gan et al., 2010, Kirilly et al., 2011, Chang et al., 2011, Dahlgaard et al., 2007, Wang et al., 1994, Liu et al., 2009, Lowery et al., 2010) CG3399 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lowery et al., 2010) CG15420
Name Synonym	cappuccino (Zhao et al., 2008, Kerkhoff, 2006, Neuman-Silberberg, 2007, Kirilly et al., 2011, Chang et al., 2011, Dahlgaard et al., 2007, Tanaka and Nakamura, 2008, Liu et al., 2009) Cappuccino (Higgs and Peterson, 2005, Baum and Kunda, 2005, Wang and Riechmann, 2008, Quinlan et al., 2007) cappucino (Rogers et al., 2003) Cappucino (Rogers et al., 2003)
Secondary FlyBase IDs
	FBgn0031576
References ( 192 )
Generate a list of	All references relating to this gene ( 192 )
List References by type	Research paper  ( 81 ) Supplementary material  ( 10 ) Review  ( 55 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 25 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 5 )
	Bor et al., 2012, Mol. Biol. Cell 23(19): 3801--3813 Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains. [FBrf0219599] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Chang et al., 2011, Genetics 188(4): 883--896 Anterior-Posterior Axis Specification in Drosophila Oocytes: Identification of Novel bicoid and oskar mRNA Localization Factors. [FBrf0214626] Kirilly et al., 2011, Development 138(23): 5087--5097 Self-maintained escort cells form a germline stem cell differentiation niche. [FBrf0216598] Tanaka et al., 2011, Development 138(12): 2523--2532 Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. [FBrf0213769] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...