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FB2025_05
,
released December 11, 2025
capp
Formin domain protein that interacts with Spire to facilitate actin filament capping and nucleation - works with spire to build an actin mesh that fills the oocyte during mid-oogenesis - necessary for polarity establishment and female fertility
Please see the JBrowse view of Dmel\capu for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
1058 (aa); 114 (kD predicted)
Interacts with wash. Interacts with spir.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\capu using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reference states 0-24 hr AEL
capu transcripts are detected as early as germarium stage 2 in the ovary. They are present in nurse cells in stage S1-S13 egg chambers. They are also detected in the oocyte nucleus from stage S4 to S9 and weakly in follicle cells from stage S4 to S11. On northern blots, capu transcripts are detected throughout embryogenesis, are absent in 1st and 2nd instars, and reappear in third instar larvae. They are also found in ovaries, in ovarectomized females, and in males.
JBrowse - Visual display of RNA-Seq signals
View Dmel\capu in JBrowse
Mapped using capu1.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
Analysis of capu mutant oocytes suggests that the microtubule cytoskeleton is misregulated resulting in premature microtubule bundling at the cortex of the oocyte and premature microtubule-dependent cytoplasmic streaming within the oocyte. Induction of premature microtubule based streaming in wild type embryos does not sweep away all previously localised molecular determinants, in support of the suggestion that the premature streaming alone cannot explain all of the patterning defects.
The posterior signal can be active at the anterior independent of capu function.
capu is required specifically for the localization, not the synthesis, of the posterior signal.
Mutations in maternal dorsal class gene capu do not interact with RpII140wimp.
Mutations at the capu locus cause defects in midoogenesis.
capu gene function affects dorsoventral and anteroposterior patterning.
capu plays a role in polar granule formation.
Source for merge of: capu CG15420
Source for merge of capu CG15420 was a shared cDNA ( date:010720 ).
