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Gene Dmel\CkIIβ

General Information
Symbol	Dmel\CkIIβ	Species	D. melanogaster
Name	Casein kinase II β subunit	Annotation symbol	CG15224
Feature type	protein_coding_gene	FlyBase ID	FBgn0000259
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	CK2, CKII, CK2β, And, DmCK2β, CKIIbeta, βCK2, CK2beta, DmCKIIβ, CK-IIβ
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	10E3-10E3	Sequence location	X:11,686,569..11,694,697 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Casein kinase II β subunit is referred to in FlyBase by the symbol Dmel\CkIIβ (CG15224, FBgn0000259). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity; protein kinase regulator activity. There is experimental evidence that it is involved in the biological process: protein phosphorylation; locomotor rhythm; mushroom body development; circadian rhythm; neurogenesis. 37 alleles are reported. The phenotypes of these alleles are annotated with: Kenyon cell; mushroom body; mushroom body calyx; peripheral nervous system; ventral nerve cord commissure; longitudinal connective; wing; wing vein. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Casein kinase II, regulatory subunit; Casein kinase II, regulatory subunit, alpha-helical; Casein kinase II, regulatory subunit, beta-sheet. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult testis, adult carcass. Gene sequence location is X:11686569..11694697.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	And: Andante (J.C. Hall) The normal free-running 24 hr periods of the circadian rhythms of eclosion and adult locomotor activity (in constant conditions) are lengthened by 1.5-2 hr/cycle; And/+ heterozygotes have a period phenotype intermediate between wild-type and mutant homozygotes (Konopka, R. Smith and Orr). The phase-response curves (PRCs) for eclosion and activity rhythms, indicating light-induced phase shifts, show a similar degree of lengthening as seen in free-running periodicities. And rhythms are highly temperature-compensated, as are those of wild-type (Konopka et al.). And males are defective in after effects on courtship behavior that are usually induced by prior exposure to mated females or very young males (Jackson et al., 1983). CkII β: Casein kinase II, β subunit The structural gene for the autophosphorylated, regulatory β subunit of casein kinase II (CKII).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Alleles CkIIbeta[Scer\UAS.T:Zzzz\FLAG] CkIIbeta[dsRNA.cJa.Scer\UAS]
FB2012_01	References Wong et al., 2011, PLoS ONE 6(9): e24355 Sequence features BKN29263 BKN50911 HFA20230 BKN51125
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10E3-10E3   Limits computationally determined from genome sequence between P{EP}EP345&P{EP}EP1409 and P{EP}ATP7EP308
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10E1-10E2   (determined by in situ hybridisation)   (Bidwai et al., 2000) 10E1-10E2     (Glover, 1996.3.28) 10E2-10E4     (DiBartolomeis and Jackson, 1989) 10E1-10F1     (Konopka et al., 1991) 10E1-10E2   (determined by in situ hybridisation)   (Saxena et al., 1987)
Experimentally Determined Recombination Data
Location
Left of (cM)	f (Konopka et al., 1991)
Right of (cM)	v (Konopka et al., 1991)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CkIIβ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CkIIβ-RB FBtr0073558  NM_080762   3118   215 CkIIβ-RC FBtr0073560  NM_167304   1329   215 CkIIβ-RD FBtr0073561  NM_167305   964   215 CkIIβ-RE FBtr0073562  NM_206692   1466   235 CkIIβ-RF FBtr0100540  NM_001014731   955   215 CkIIβ-RG FBtr0299569  NM_078576   995   215 CkIIβ-RH FBtr0307896     2376   215 CkIIβ-RI FBtr0308084     1552   233 CkIIβ-RJ FBtr0308085     931   233
Additional Transcript Data & Comments
Reported size (kB)	0.946 (longest cDNA) (Saxena et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CkIIβ-PB   FBpp0073403   24.8   215   5.29     NP_542940   AAF48093 CkIIβ-PC   FBpp0073405   24.8   215   5.29     NP_727561   AAF48094 CkIIβ-PD   FBpp0073406   24.8   215   5.29     NP_727562   AAN09298 CkIIβ-PE   FBpp0089135   27.1   235   4.99     NP_996415   AAS65321 CkIIβ-PF   FBpp0099985   24.8   215   5.29     NP_001014731   AAX52485 CkIIβ-PG   FBpp0288844   24.8   215   5.29     NP_511131   AAF48092 CkIIβ-PH   FBpp0300330   24.8   215   5.29       CkIIβ-PI   FBpp0300427   26.8   233   4.61       CkIIβ-PJ   FBpp0300428   26.9   233   5.28
Additional Polypeptide Data & Comments
Reported size (kDa)	215 (aa); 24.7 (kD predicted) (Saxena et al., 1987) 28.2 (kD observed) (Glover et al., 1983)
Comments	Two CkIIα polypeptides plus two CkIIβ polypeptides form a 130 kD tetramer. (Dahmus et al., 1984)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Casein kinase II, regulatory subunit (IPR000704) Casein kinase II, regulatory subunit, alpha-helical (IPR016149) Casein kinase II, regulatory subunit, beta-sheet (IPR016150)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263902   AA735984   AE014298 AAF48092   AE014298 AAF48093   AE014298 AAF48094   AE014298 AAN09298   AE014298 AAS65321   AE014298 AAX52485   AF236850 AAF62920   AF236851 AAF62921   AF236852 AAF62922   AI109297   AI109634   AI387980   AI517689   AI945171   AY113447 AAM29452   BE978385   BG633509   BG634847   BI214079   BI230719   BI231261   BI235229   BI236976   BI243852   BI367082   BI368534   BI486990   BI577192   BI580319   BI580487   BP546437   BP547990   BP560295   BP560296   BT100023   BT120031   CO156780   CO176942   CO177539   CO181773   CO185810   CO187154   CO187465   CO187742   CO261812   CO262342   CO263083   CO264869   CO266719   CO267059   CO267061   CO268008   CO269666   CO272493   CO272932   CO275513   CO275868   CO277082   CO278902   CO280915   CO288032   CO288036   CO288389   CO288455   CO290315   CO291078   CO291815   CO292048   CO292700   CO293473   CO297291   CO298744   CO300628   CO304231   CO304658   CO305757   CO309255   CO316601   CO318670   CO319956   CO322569   CO328744   CO336803   CO338464   CO339844   CO343454   CS133191   EC057575   EC059902   EC060236   EC060346   EC063662   EC066512   EC070543   EC075244   EC085498   EC085651   EC088653   EC088840   EC090544   EC197117   EC198507   EC199084   EC204218   EC207095   EC207569   EC207606   EC211719   EC211911   EC214191   EC215472   EC215928   EC218082   EC218952   EC219200   EC224022   EC224529   EC226092   EC227213   EC227350   EC227737   EC228389   EC230611   EC231051   EC233241   EC235507   EC237085   EC238330   EC238993   EC240880   EC243327   EC243500   EC245280   EC261668   EC262377   EL875327   EV583572   EV590007   GH943666   GH949774   GH953444   GH956271   GH957238   GH963944   GH973739   GH982813   M16535 AAA28430   U52952 AAC13880
UniProtKB/Swiss-Prot	P08182
UniProtKB/TrEMBL	Q9NGY7 Q9NGY8 Q9NGY9 A4V4C1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000259    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000259 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000259 expression level Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3277) embryo 02-04hr  (1530) embryo 04-06hr  (2344) embryo 06-08hr  (3019) embryo 08-10hr  (3040) embryo 10-12hr  (1991) embryo 12-14hr  (3362) embryo 14-16hr  (1854) embryo 16-18hr  (1911) embryo 18-20hr  (1243) embryo 20-22hr  (940) embryo 22-24hr  (1278) larva L1  (2090) larva L2  (2233) larva L3 12hr old  (1467) larva L3 puffstage 1-2  (1280) larva L3 puffstage 3-6  (1945) larva L3 puffstage 7-9  (2908) white prepupae new  (3268) white prepupae 12hr  (3043) white prepupae 24hr  (3336) pupae 2d postWPP  (3216) pupae 3d postWPP  (2354) pupae 4d postWPP  (1284) adult male 01day  (1284) adult male 05day  (1245) adult male 30day  (1346) adult female 01day  (2116) adult female 05day  (3352) adult female 30day  (2994) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3277) embryo 02-04hr  (1530) embryo 04-06hr  (2344) embryo 06-08hr  (3019) embryo 08-10hr  (3040) embryo 10-12hr  (1991) embryo 12-14hr  (3362) embryo 14-16hr  (1854) embryo 16-18hr  (1911) embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1  (2090) larva L2  (2233) larva L3 12hr old  1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6  (1945) larva L3 puffstage 7-9  (2908) white prepupae new  (3268) white prepupae 12hr  (3043) white prepupae 24hr  (3336) pupae 2d postWPP  (3216) pupae 3d postWPP  (2354) pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day  (2116) adult female 05day  (3352) adult female 30day  (2994) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000259 expression level Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3277) embryo 02-04hr  (1530) embryo 04-06hr  (2344) embryo 06-08hr  (3019) embryo 08-10hr  (3040) embryo 10-12hr  (1991) embryo 12-14hr  (3362) embryo 14-16hr  (1854) embryo 16-18hr  (1911) embryo 18-20hr  (1243) embryo 20-22hr  (940) embryo 22-24hr  (1278) larva L1  (2090) larva L2  (2233) larva L3 12hr old  (1467) larva L3 puffstage 1-2  (1280) larva L3 puffstage 3-6  (1945) larva L3 puffstage 7-9  (2908) white prepupae new  (3268) white prepupae 12hr  (3043) white prepupae 24hr  (3336) pupae 2d postWPP  (3216) pupae 3d postWPP  (2354) pupae 4d postWPP  (1284) adult male 01day  (1284) adult male 05day  (1245) adult male 30day  (1346) adult female 01day  (2116) adult female 05day  (3352) adult female 30day  (2994) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3277) embryo 02-04hr  1530 embryo 04-06hr  2344 embryo 06-08hr  (3019) embryo 08-10hr  (3040) embryo 10-12hr  1991 embryo 12-14hr  (3362) embryo 14-16hr  1854 embryo 16-18hr  1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1  2090 larva L2  2233 larva L3 12hr old  1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6  1945 larva L3 puffstage 7-9  (2908) white prepupae new  (3268) white prepupae 12hr  (3043) white prepupae 24hr  (3336) pupae 2d postWPP  (3216) pupae 3d postWPP  2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day  2116 adult female 05day  (3352) adult female 30day  (2994) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3277 embryo 02-04hr    1530 embryo 04-06hr    2344 embryo 06-08hr    3019 embryo 08-10hr    3040 embryo 10-12hr    1991 embryo 12-14hr    3362 embryo 14-16hr    1854 embryo 16-18hr    1911 embryo 18-20hr    1243 embryo 20-22hr    940 embryo 22-24hr    1278 larva L1    2090 larva L2    2233 larva L3 12hr old    1467 larva L3 puffstage 1-2    1280 larva L3 puffstage 3-6    1945 larva L3 puffstage 7-9    2908 white prepupae new    3268 white prepupae 12hr    3043 white prepupae 24hr    3336 pupae 2d postWPP    3216 pupae 3d postWPP    2354 pupae 4d postWPP    1284 adult male 01day    1284 adult male 05day    1245 adult male 30day    1346 adult female 01day    2116 adult female 05day    3352 adult female 30day    2994 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000259    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000259 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval fat body, larval salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult spermathecae, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000259 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15224-RB;CG15224-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CkIIβmbuΔA26-2L lethal, with Scer\GAL41407 CkIIβGD8571 lethal, with Scer\GAL4αTub84B.PL CkIIβVIIb.Scer\UAS CkIIβVIId.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 CkIIβGD8571 lethal | recessive CkIIβmbuΔA26-2L viable CkIIβBG02223 CkIIβGT1.Δ6 CkIIβGT1.Δ8 CkIIβmbuP1 viable, with Scer\GAL4αTub84B.PL CkIIβIe-VIIa.Scer\UAS CkIIβVIIc.Scer\UAS CkIIβVIId-VI.Scer\UAS Sterility Allele female sterile | partially CkIIβmbuP1 male sterile | partially CkIIβmbuP1 Other Phenotypes Allele behavior defective | semidominant CkIIβAnd circadian behavior defective, with Scer\GAL4P2.4.Pdf CkIIβdsRNA.fl.Scer\UAS circadian rhythm defective CkIIβAnd CkIIβmbuP1 CkIIβmbuΔA6-1 CkIIβmbuΔA20-1L CkIIβmbuΔA26-2L circadian rhythm defective, with Scer\GAL4P2.4.Pdf CkIIβdsRNA.fl.Scer\UAS circadian rhythm defective (with CkIIβAnd) CkIIβmbuP1 CkIIβmbuΔA6-1 CkIIβmbuΔA20-1L CkIIβmbuΔA26-2L circadian rhythm defective (with CkIIβmbuP1) CkIIβAnd circadian rhythm defective (with CkIIβmbuΔA6-1) CkIIβAnd circadian rhythm defective (with CkIIβmbuΔA20-1L) CkIIβAnd circadian rhythm defective (with CkIIβmbuΔA26-2L) CkIIβAnd eclosion rhythm defective CkIIβAnd locomotor rhythm defective CkIIβAnd locomotor rhythm defective, with Scer\GAL4P2.4.Pdf CkIIβdsRNA.fl.Scer\UAS locomotor rhythm defective | semidominant CkIIβAnd neuroanatomy defective CkIIβAnd CkIIβdsRNA.cIb CkIIβmbuP1 neuroanatomy defective (with CkIIβAnd) CkIIβmbuΔA26-2L neuroanatomy defective (with CkIIβmbuP1) CkIIβmbuΔA26-2L neuroanatomy defective (with CkIIβmbuΔA26-2L) CkIIβAnd CkIIβmbuP1 neuroanatomy defective | larval stage, with Scer\GAL41407 CkIIβGD8571 visible CkIIβAnd visible, with Scer\GAL4C-765 CkIIβdsRNA.cJa.Scer\UAS visible, with Scer\GAL4ptc-559.1 CkIIβdsRNA.cJa.Scer\UAS Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CkIIβGD8571 ganglion mother cell | larval stage, with Scer\GAL41407 CkIIβGD8571 Kenyon cell CkIIβmbuP1 longitudinal connective CkIIβdsRNA.cIb mushroom body CkIIβmbuP1 mushroom body calyx CkIIβAnd CkIIβmbuP1 mushroom body calyx, with CkIIβmbuΔA26-2L, Scer\GAL4αTub84B.PL CkIIβVIIb.Scer\UAS mushroom body calyx, with CkIIβVIIb.Scer\UAS, Scer\GAL4αTub84B.PL CkIIβmbuΔA26-2L mushroom body calyx (with CkIIβAnd) CkIIβmbuΔA26-2L mushroom body calyx (with CkIIβmbuP1) CkIIβmbuΔA26-2L mushroom body calyx (with CkIIβmbuΔA26-2L) CkIIβAnd CkIIβmbuP1 mushroom body calyx (with CkIIβmbuΔA26-2L), with Scer\GAL4αTub84B.PL CkIIβVIIb.Scer\UAS mushroom body calyx (with CkIIβVIIb.Scer\UAS), with Scer\GAL4αTub84B.PL CkIIβmbuΔA26-2L peripheral nervous system CkIIβdsRNA.cIb ventral nerve cord commissure CkIIβdsRNA.cIb wing CkIIβAnd wing | somatic clone CkIIβAnd wing vein, with Scer\GAL4C-765 CkIIβdsRNA.cJa.Scer\UAS wing vein, with Scer\GAL4ptc-559.1 CkIIβdsRNA.cJa.Scer\UAS
Classical Alleles ( 16 )
For All Classical Alleles Show
Allele of CkIIβ Class Mutagen Stocks Known lesion CkIIβ5-SZ-4065 1 -- CkIIβBG02223 P-element activity 1 Yes CkIIβd05428 1 -- CkIIβe04387 1 -- CkIIβEY21591 P-element activity 1 -- CkIIβ5-HA-2543 0 -- CkIIβAnd hypomorphic allele - genetic evidence ethyl methanesulfonate gamma ray 0 Yes CkIIβGG01641 0 -- CkIIβGG01753 0 -- CkIIβGT1.Δ6 Delta2-3 0 -- CkIIβGT1.Δ8 Delta2-3 0 -- CkIIβmbuP1 hypomorphic allele - genetic evidence P-element activity 0 Yes CkIIβmbuΔA20-1L P-element activity 0 Yes CkIIβmbuΔA26-2L loss of function allele Delta2-3 P-element activity 0 Yes CkIIβmbuΔA6-1 P-element activity 0 Yes CkIIβmbuΔA Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CkIIβ Class Mutagen Stocks Known lesion CkIIβGD8571 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CkIIβGL00303 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIIβHMS00058 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIIβJF01195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIIβKK109263 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CkIIβC109.114S.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes CkIIβC137.140S.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes CkIIβdsRNA.cIa in vitro construct - RNAi 0 Yes CkIIβdsRNA.cIb in vitro construct - RNAi 0 Yes CkIIβdsRNA.cJa.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CkIIβdsRNA.fl.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes CkIIβgDNA in vitro construct 0 Yes CkIIβIe-VIIa.Scer\UAS in vitro construct - regulatory fusion 0 Yes CkIIβR47C.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes CkIIβS2.3.4A.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes CkIIβScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes CkIIβVIIa-M166I.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes CkIIβVIIb.Scer\UAS in vitro construct - regulatory fusion 0 Yes CkIIβVIIc.Scer\UAS in vitro construct - regulatory fusion 0 Yes CkIIβVIId-VI.Scer\UAS in vitro construct - regulatory fusion 0 Yes CkIIβVIId.Scer\UAS in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-CkIIβ.C109.114S} NA P{UAS-CkIIβ.C137.140S} NA P{UAS-CkIIβ.Ie-VIIa} NA P{UAS-CkIIβ.R47C} NA P{UAS-CkIIβ.S2.3.4A} NA characterization construct P{CkIIβ.gDNA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?lacW}CkIIβmbuΔA6-1 NA P{?lacW}CkIIβmbuΔA NA P{GT1}CkIIβBG02223 NA P{RS5}CkIIβ5-HA-2543 NA P{RS5}CkIIβ5-SZ-4065 NA PBac{RB}CkIIβe04387 NA insertion of mobile activating element P{EPgy2}CkIIβEY21591 NA P{Mae-UAS.6.11}CkIIβGG01641 NA P{Mae-UAS.6.11}CkIIβGG01753 NA P{XP}CkIIβd05428 NA insertion of enhancer trap P{lacW}CkIIβmbuP1a No P{lacW}CkIIβmbuP1b No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein kinase regulator activity inferred from direct assay (Tiganis et al., 1993) protein serine/threonine kinase activity inferred from direct assay (Glover et al., 1983, Dahmus et al., 1984)
Biological Process
CV term Evidence References
circadian rhythm inferred from mutant phenotype (Akten et al., 2003) locomotor rhythm inferred from mutant phenotype (Akten et al., 2009) mushroom body development inferred from mutant phenotype (Jauch et al., 2002, Jauch et al., 2006) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) protein phosphorylation inferred from direct assay (Glover et al., 1983)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Siomi et al., 2002) cytosol inferred from direct assay (Glover et al., 1983) nucleus inferred from direct assay (Glover et al., 1983) protein kinase CK2 complex inferred from direct assay (Glover et al., 1983)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
protein kinase activity non-traceable author statement (Morrison et al., 2000) protein kinase regulator activity inferred from sequence or structural similarity with UniProtKB:P28021 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Biological Process
CV term Evidence References
eclosion rhythm traceable author statement (Stanewsky, 2003) protein phosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1988.8.1) rhythmic behavior traceable author statement (Stanewsky, 2003)
Cellular Component
CV term Evidence References
protein kinase CK2 complex non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CkIIβ allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000259 DroID - A comprehensive database of gene and protein interactions. • FBgn0000259 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32132
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20435 Dere\GG18445 Dgri\GH12745 Dmoj\GI15890 Dsec\GM13109 Dsim\GD17050 Dvir\GJ16637 Dwil\GK14838 Dyak\GE15667
Curated drosophilid orthologs	Dpse\GA13583
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP011438-PA Anopheles gambiae (mosquito) XP_624048.1 Apis mellifera (honey bee) NP_001119697.1 Acyrthosiphon pisum (pea aphid) At2g44680.1 Arabidopsis thaliana (wall cress) 15229 Batrachochytrium dendrobatidis (chytrid fungus) 106030 Branchiostoma floridae (lancelet) 59924 Branchiostoma floridae (lancelet) XP_001894704.1 Brugia malayi (roundworm nematode) BGIBMGA007942-PA Bombyx mori (silk worm) ENSBTAP00000042926 Bos taurus (bovine) CAL0000389 Candida albicans (a form of yeast) CN14167 Caenorhabditis brenneri (small nematode) CBP28034 Caenorhabditis briggsae (nematode) CE06343 Caenorhabditis elegans (worm) ENSCAFP00000000847 Canis familiaris (dog) CAGL0I00946g Candida glabrata (haploid yeast) ENSCINP00000025110 Ciona intestinalis (sea squirt) JA10154 Caenorhabditis japonica (nematode) CMM005C Cyanidioschyzon merolae (red alga) cn05241 Cryptococcus neoformans (yeast-like fungus) cgd3_3670 Cryptosporidium parvum (protozoan parasite) CPIJ014996 Culex pipens (mosquito) ENSCPOP00000009689 Cavia porcellus (guinea pig) 116537 Chlamidomonas reinhardtii (green alga) RP21799 Caenorhabditis remanei (nematode) ENSCSAVP00000015699 Ciona savignyi (sedentary tunicate) 223599 Capitella spl (polychaete worm) DDB0216346 Dictyostelium discoideum (amoeba) DEHA2G08206g Debaryomyces Hansenii (yeast) 305830 Daphnia pulex (daphnia) ENSDARP00000067791 Danio rerio (zebra fish) ENSECAP00000018636 Equus caballus (horse) ENSGACP00000010480 Gymnopilus aculeatus (mushroom) GL50803_7421 Giardia lamblia (flagellated protozoan) 104986 Hypsipyla robusta (cedar shoot borer) ENSP00000365046 Homo sapiens (human) ENSP00000382949 Homo sapiens (human) ENSP00000382984 Homo sapiens (human) ISCW014459-PA Ixodes scapularis (deer tick) KLLA0E21869g Kluyveromyces lactis (yeast) 225993 Lottia gigantea (owl limpet) LmjF36.5090 Leishmania major (virus) 13118 Monocosta brevicollis (choanoflagellate) ENSMODP00000019093 Monodelphis domestica (gray opossum) ENSMMUP00000006997 Macaca mulatta (rhesus monkey) ENSMUSP00000025246 Mus musculus (house mouse) 245041 Nematostella vectensis (starlet anemone) XP_001606149.1 Nasonia vitripennis (wasp) ENSORLP00000008637 Oryzias latipes (japanese killifish) LOC_Os10g41520.1 Oryza sativa (asian rice) 6069 Ostreococcus tauri (green alga) PF13_0232 Plasmodium falciparum (protozoal parasite) PHUM003933-PA Pediculus humanus (human body louse) PP14926 Pristionchus pacificus (nematode) 219176 Physcomitrella patens (moss) ENSPPYP00000018392 Pongo pygmaeus (orangutan) 97155 Phytophthora ramorum (sudden oak death pathogen) 158138 Phytophthora sojae (root rot pathogen) 830334 Populus trichocarpa (black cottonwood) ENSPTRP00000030673 Pan troglodytes (chimpanzee) PVX_083020 Plasmodium vivax (protozoal parasite) ENSRNOP00000001123 Rattus norvegicus (norway rat) 4875675 Sorghum bicolor (sorghum) YOR039W Saccharomyces cerevisiae (budding yeast) Smp_025010.1 Schistosoma mansoni (trematode parasite) SPAC1851.03 Schizosaccharomyces pombe (fission yeast) XP_001189637.1 Strongylocentrotus purpuratus (purple sea urchin) 6279 Trichoplax adhaerens (metazoa) TA13995 Theileria annulata (apicomplexan parasite) XP_966313.1 Tribolium castaneum (red flour beetle) Tc00.1047053503757.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021625 Tetraodon nigroviridis (green spotted pufferfish) TP02_0584 Theileria parva (parasitic protozoan) 17208 Thalassiosira pseudonana (marine diatom) ENSTRUP00000001953 Takifugu rubripes (pufferfish Takifugu) 3738.m00011 Tetrahymena thermophila (ciliate protozoa) 89667.m00110 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000058038 Xenopus tropicalis (frog) YALI0E20955g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15579 NV12441 LH23402 ISCW014459 FBgn0233237 FBgn0216843 FBgn0203821 FBgn0188623 FBgn0168040 JGI_V11_305830 FBgn0157792 FBgn0138639 FBgn0120224 FBgn0110660 FBgn0097442 CPIJ014996 BGIBMGA007942 ACYPI000089 GB12504 AGAP011438 AAEL017447 PHUM490980 GLEAN_00224
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	12739 P{GT1}CkIIβBG02223 w1118 31254 y1 v1; P{TRiP.JF01195}attP2 22488 y1 w67c23 P{EPgy2}CkIIβEY21591 35385 y1 sc* v1; P{TRiP.GL00303}attP2 34939 y1 sc* v1; P{TRiP.HMS00058}attP2
Harvard	- P{XP}CkIIβd05428 - PBac{RB}CkIIβe04387
Kyoto	126321 w1118 P{RS5}CkIIβ5-SZ-4065
VDRC	v106845 P{KK109263}VIE-260B v32377 w1118; P{GD8571}v32377/TM3 v32378 w1118; P{GD8571}v32378/TM3
Genomic Clones ( 1 )
	BACR46E23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 136 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE20707 RE31047
Other clones	DPiM_RE31047 MIP14664
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT31207 GH08440 GH08877 GH18688 GH28737 GM10245 LD07133 RE14745 RE19782 RE33117 RE41648 RE52756 RE54521 RE70482 RE70843 RE74494 RE74684
Other clones	1734 8556 19041 30828 36441 42099 55581 57801 60038 62635 70712 71043 72243 73914 77703 105852 117358 122112 123582 146464 157986 161528 163990 165132 172700 174381 174736 176385 190098 273830 283179 561862 571434 bs09g07 bs78a12 CK01.30C.G8 CK01.33C.D1 CK01.50B.A6 CK01.66A.E8 CK01.85B.F4 CK01.85B.G4 CK01.86D.C12 CK01.86D.D3 CK01.94C.G8 CK01.98B.E8 CK01.100D.D1 CK01.118C.H9 CK01.141C.F12 CK01.142B.E9 CK01.170A.H4 Dmel_dig_016046_0648_0927 Dmel_neb_010811_0410_2596 EC14958 EK012601 EK026760 EK029910 EK032463 EK051702 EK053752 EK067554 EK067558 EK068414 EK068542 EK073660 EK076052 EK079809 EK085113 EK087409 EK089929 EK095506 EK107361 EK108905 EK117756 EK119017 EK122919 EK132151 EK140543 EK147333 EK148602 EK148607 EK155455 EK173732 EK178832 EK188413 EK198413 EK199055 EK200760 EK203001 EK216602 EK244147 EK245443 EK249354 EK260840 EK265355 EK273402 EK281553 EK291315 EN09306 EN13255 EN16851 EP09511 EP16814 FGH106D07 FGH122H01 FGM325G04 IP15325 RP004063090 RP004082414 RP004129190 RP004179506 RP004216658 RP004248535 RP004376738 RP004510036
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000259 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32132
Antibody Information
	polyclonal (Dahmus et al., 1984)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CkIIβ mbu (Kibler et al., 2001)
Additional comments	Drosophila Casein kinase II α and β subunits can rescue the lethality of S.cerevisiae deleted for both genes. (Bidwai et al., 1992)
Other Comments
	Splice isoforms CkIIβ-VIIc and -VIId are dispensable for viability and for formation of normal mushroom bodies. (Jauch et al., 2006) CkIIβ dependant phosphorylation has a role in the circadian rhythm. (Akten et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The 'Andante' mutant carries two independent EMS-induced mutations, one in dy (dyQ189stop) and one in CkIIβ (CkIIβAnd). It is the one in CkIIβAnd that is responsible for the circadian long-period phenotype. (Jackson, 2002.7.26) The number of neurons forming the adult mushroom body is greatly reduced in CkIIβ hypomorphs. (Jauch et al., 2002) Mutations in CkIIβ reduce the number of mushroom body neurons (Kenyon cells). (Prado et al., 1999) Stimulation of CkIIβ activity by a polyamine molecule and its binding efficiency toward CkIIβ rely not only on its number of positive charges but also on the length of its aliphatic chain. (Leroy et al., 1997) Casein kinase II specifically phosphorylates a set of serine residues within the cact PEST domain. (Liu et al., 1997) Casein kinase II phosphorylates Ser468 (a residue in the PEST domain) of cact in vitro. (Packman et al., 1997) Casein kinase II (encoded by CkIIα and CkIIβ) phosphorylates dsh in vitro. This phosphorylation is regulated by fz2, implicating a role for Casein kinase II in wg signalling. (Willert et al., 1997) Genetic mosaic analysis identifies the tissues that require the CkIIβ product. (Newby and Jackson, 1995) Serine 2 and Serine 4 residues are major sites of autophosphorylation of the β subunit of casein kinase (as shown by the construction of A2 and A4 mutants in vitro). Autophosphorylation of this subunit reduces the phosphorylation of some substrate proteins in vitro (calmodulin, elongation factor 1, glycogen synthase) but not of others (casein). (Jakobi et al., 1994) Recombinant CkII in vitro binds to spermine and this interaction is concomitant with a striking effect on the structural polymeric organisation on the kinase which in the presence of the polyamine exhibits a ring-like structure. (Leroy et al., 1994) Chimeric β subunits of human and Drosophila cDNA reveal that the N terminal region of the CkIIβ subunit is responsible for the requirement for the redox state during renaturation, and is also responsible for solubility and electrophoretic mobility. of S.cerevisiae deleted for both genes. (Lin et al., 1994) Recombinant Casein kinase reconstituted from human and Drosophila, α and β subunits demonstrate that CkIIβ is responsible for renaturation and reconstitution of Casein kinase II dependent on the redox conditions. (Lin et al., 1994) CkIIβ is primarily an inhibitor of the catalytic activity of CkIIα in the absence of salt. (Tiganis et al., 1993) Casein kinase II-mediated phosphorylation of Top2 stimulates its activity by enhancing the ability of the enzyme to hydrolyse its high energy ATP cofactor. (Corbett et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078576 NM_080762 NM_167304 NM_167305 NM_206692 NM_001014731 RefSeq (Proteins) • NP_511131 NP_542940 NP_727561 NP_727562 NP_996415 NP_001014731 DDBJ / EMBL / GenBank • AAA28430 AAC13880 AAF48092 AAF48092.1 AAF48092.2 AAF48093 AAF48093.1 AAF48094 AAF48094.1 AAF62920 AAF62921 AAF62922 AAM29452 AAN09298 AAN09298.1 AAS65321 AAS65321.1 AAX52485 AF236850 AF236851 AF236852 AI109297 AI109634 AI387980 AI517689 AI945171 AY113447 BG633509 BG634847 BI231261 BI235229 CS133191 M16535 U52952 Entrez Gene - A searchable database of RefSeq genes. • 32132 UniProtKB/Swiss-Prot • P08182 UniProtKB/TrEMBL • A4V4C1 Q9NGY7 Q9NGY8 Q9NGY9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Casein kinase II, regulatory subunit (IPR000704) Casein kinase II, regulatory subunit, alpha-helical (IPR016149) Casein kinase II, regulatory subunit, beta-sheet (IPR016150)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000259 DroID - A comprehensive database of gene and protein interactions. • FBgn0000259 DRSC - Results from RNAi screens. • FBgn0000259 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000259 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15224-RB;CG15224-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000259 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 93712 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32132 InParanoid A subset of ortholog calls from InParanoid. • AGAP011438-PA Anopheles gambiae (mosquito) XP_624048.1 Apis mellifera (honey bee) NP_001119697.1 Acyrthosiphon pisum (pea aphid) At2g44680.1 Arabidopsis thaliana (wall cress) 15229 Batrachochytrium dendrobatidis (chytrid fungus) 106030 Branchiostoma floridae (lancelet) 59924 Branchiostoma floridae (lancelet) XP_001894704.1 Brugia malayi (roundworm nematode) BGIBMGA007942-PA Bombyx mori (silk worm) ENSBTAP00000042926 Bos taurus (bovine) CAL0000389 Candida albicans (a form of yeast) CN14167 Caenorhabditis brenneri (small nematode) CBP28034 Caenorhabditis briggsae (nematode) CE06343 Caenorhabditis elegans (worm) ENSCAFP00000000847 Canis familiaris (dog) CAGL0I00946g Candida glabrata (haploid yeast) ENSCINP00000025110 Ciona intestinalis (sea squirt) JA10154 Caenorhabditis japonica (nematode) CMM005C Cyanidioschyzon merolae (red alga) cn05241 Cryptococcus neoformans (yeast-like fungus) cgd3_3670 Cryptosporidium parvum (protozoan parasite) CPIJ014996 Culex pipens (mosquito) ENSCPOP00000009689 Cavia porcellus (guinea pig) 116537 Chlamidomonas reinhardtii (green alga) RP21799 Caenorhabditis remanei (nematode) ENSCSAVP00000015699 Ciona savignyi (sedentary tunicate) 223599 Capitella spl (polychaete worm) DDB0216346 Dictyostelium discoideum (amoeba) DEHA2G08206g Debaryomyces Hansenii (yeast) 305830 Daphnia pulex (daphnia) ENSDARP00000067791 Danio rerio (zebra fish) ENSECAP00000018636 Equus caballus (horse) ENSGACP00000010480 Gymnopilus aculeatus (mushroom) GL50803_7421 Giardia lamblia (flagellated protozoan) 104986 Hypsipyla robusta (cedar shoot borer) ENSP00000365046 Homo sapiens (human) ENSP00000382949 Homo sapiens (human) ENSP00000382984 Homo sapiens (human) ISCW014459-PA Ixodes scapularis (deer tick) KLLA0E21869g Kluyveromyces lactis (yeast) 225993 Lottia gigantea (owl limpet) LmjF36.5090 Leishmania major (virus) 13118 Monocosta brevicollis (choanoflagellate) ENSMODP00000019093 Monodelphis domestica (gray opossum) ENSMMUP00000006997 Macaca mulatta (rhesus monkey) ENSMUSP00000025246 Mus musculus (house mouse) 245041 Nematostella vectensis (starlet anemone) XP_001606149.1 Nasonia vitripennis (wasp) ENSORLP00000008637 Oryzias latipes (japanese killifish) LOC_Os10g41520.1 Oryza sativa (asian rice) 6069 Ostreococcus tauri (green alga) PF13_0232 Plasmodium falciparum (protozoal parasite) PHUM003933-PA Pediculus humanus (human body louse) PP14926 Pristionchus pacificus (nematode) 219176 Physcomitrella patens (moss) ENSPPYP00000018392 Pongo pygmaeus (orangutan) 97155 Phytophthora ramorum (sudden oak death pathogen) 158138 Phytophthora sojae (root rot pathogen) 830334 Populus trichocarpa (black cottonwood) ENSPTRP00000030673 Pan troglodytes (chimpanzee) PVX_083020 Plasmodium vivax (protozoal parasite) ENSRNOP00000001123 Rattus norvegicus (norway rat) 4875675 Sorghum bicolor (sorghum) YOR039W Saccharomyces cerevisiae (budding yeast) Smp_025010.1 Schistosoma mansoni (trematode parasite) SPAC1851.03 Schizosaccharomyces pombe (fission yeast) XP_001189637.1 Strongylocentrotus purpuratus (purple sea urchin) 6279 Trichoplax adhaerens (metazoa) TA13995 Theileria annulata (apicomplexan parasite) XP_966313.1 Tribolium castaneum (red flour beetle) Tc00.1047053503757.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000021625 Tetraodon nigroviridis (green spotted pufferfish) TP02_0584 Theileria parva (parasitic protozoan) 17208 Thalassiosira pseudonana (marine diatom) ENSTRUP00000001953 Takifugu rubripes (pufferfish Takifugu) 3738.m00011 Tetrahymena thermophila (ciliate protozoa) 89667.m00110 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000058038 Xenopus tropicalis (frog) YALI0E20955g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/cask2-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32132 modMine - Data generated by the modENCODE project. • FBgn0000259 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15579 NV12441 LH23402 ISCW014459 FBgn0233237 FBgn0216843 FBgn0203821 FBgn0188623 FBgn0168040 JGI_V11_305830 FBgn0157792 FBgn0138639 FBgn0120224 FBgn0110660 FBgn0097442 CPIJ014996 BGIBMGA007942 ACYPI000089 GB12504 AGAP011438 AAEL017447 PHUM490980 GLEAN_00224
Synonyms & Secondary IDs ( 42 )
Reported As
Symbol Synonym	And (Rosato et al., 1997, DiBartolomeis and Jackson, 1989, Jackson and Newby, 1993, Hall, 1992, Konopka et al., 1991, Dunlap, 1990, Hall, 1990, Jackson et al., 1983) Cask-II-b   CCK2 (Valero et al., 1997) CG15224 (Morrison et al., 2000, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) CK2 (Hardin, 2005, Tie et al., 2005, Akten et al., 2003, Lin et al., 2002, Wharton, 2003, Li et al., 1999, Nusse et al., 1997, Willert et al., 1997, Cadigan and Nusse, 1997, Leroy et al., 1997, Filhol et al., 1996, Kahali et al., 2006, Bose et al., 2006, Remus et al., 2005, Bose et al., 2008, Yu and Hardin, 2006) CK-2 (Goueli and Ahmed, 1991) CK2beta (Jauch and Raabe, 2003, Zhang et al., 2009) CK2β (Kalmykova et al., 2002, Smith et al., 2006, Jauch et al., 2006, Kahali et al., 2008, Akten et al., 2009, Zhang et al., 2010, Zhang et al., 2010, Stark et al., 2011, Jia et al., 2010) CK2-β (Lear et al., 2005) CKII (Schoning and Staiger, 2005, Nawathean and Rosbash, 2004, Horiuchi et al., 2004, Bandhakavi et al., 2003, Waggener and DiMario, 1999, Zhao and Eissenberg, 1999, Brown and Moon, 1998, Liu et al., 1997, Wilson et al., 1997, Tsubota et al., 1997, Liu et al., 1997, Packman et al., 1997, Corbett et al., 1993, Li et al., 2002) CK II (Horiuchi et al., 2000) CkII (Anonymous, 1998) CKIIb (Morrison et al., 2000) CKIIbeta (Gonzalez et al., 2002) CkIIbeta (Giot et al., 2003, Neumüller et al., 2011) CKII beta (Zhang et al., 2010) CKII-beta1 (Glover, 1996.3.28) CkII-β (Ceriani et al., 2002) CKIIβ (Karandikar et al., 2003, Ishizuka et al., 2002, Zhao et al., 2002, Lee et al., 1999, Stuart et al., 2007) CK-IIβ (Karino et al., 1996) CK-II β (Bourbon et al., 1995) CkIIβ (Kunttas-Tatli et al., 2009, Akten et al., 2009, Yang et al., 2008, Zhang et al., 2010) Ck-IIβ (Menon and Meller, 2009) CkIIβ1 (Kibler et al., 2001) dCK2β (Bouazoune and Brehm, 2005, Sawatsubashi et al., 2010) dCKII (Jin and Warren, 2003) dCKII beta (Siomi et al., 2002) DmCK2β (Akten et al., 2003, Jauch et al., 2002, Jauch et al., 2006, Kalive et al., 2001, Mentzel et al., 2009) DmCKIIβ (Bidwai et al., 2000) DmCkIIβ (Trott et al., 2001) Ds cas kin (Livak, 1990) KC2B_DROME (Storm and Sonnhammer, 2003) mbu (Prado et al., 1999, ) βCK2 (Gvozdev et al., 2000, Kalmykova et al., 1997, Bonet et al., 2005)
Name Synonym	Andante (Sehgal, 1995, Akten et al., 2003, Newby and Jackson, 1995, Konopka et al., 1991, Akten et al., 2009, Hall, 2003) casein kinase 2 (Van Gelder et al., 2003, Remus et al., 2005, Yu and Hardin, 2006, Bonet et al., 2005) casein kinase 2 regulatory subunit (Akten et al., 2009) Casein kinase II (Liu et al., 1997, Corbett et al., 1992) casein kinase II (Zhang et al., 2010) Casein kinase II β subunit   CK2 (beta subunit) (Aoyagi and Wassarman, 2001) mushroom bodies undersized (Prado et al., 1999)
Secondary FlyBase IDs
	FBgn0027953
References ( 139 )
Generate a list of	All references relating to this gene ( 139 )
List References by type	Research paper  ( 77 ) Supplementary material  ( 7 ) Review  ( 20 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 17 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 7 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Stark et al., 2011, Cell. Signal. 23(5): 876--882 Protein kinase CK2 links polyamine metabolism to MAPK signalling in Drosophila. [FBrf0213122] Wong et al., 2011, PLoS ONE 6(9): e24355 The Functioning of the Drosophila CPEB Protein Orb Is Regulated by Phosphorylation and Requires Casein Kinase 2 Activity. [FBrf0216252] Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. [FBrf0214177] Sawatsubashi et al., 2010, Genes Dev. 24(2): 159--170 A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. [FBrf0209754] Zhang et al., 2010, Curr. Biol. 20(7): 591--599 DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila. [FBrf0210593] Zhang et al., 2010, Genetics 184(4): 1165--1179 A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. [FBrf0210722] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...