FlyBase Gene Report: Dmel\Cat

General Information

Symbol

Dmel\Cat

Species

D. melanogaster

Name

Catalase

Annotation Symbol

CG6871

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000261

Gene Model Status

Current

Stock Availability

20 publicly available

Enzyme Name (EC)

catalase (1.11.1.6)

Gene Summary

Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

DMCATHPO, CATA

Key Links

Genomic Location

Cytogenetic map

75E1-75E1

Sequence location

3L:18,822,604..18,828,188 [+]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:18822604..18828188

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables catalase activity

inferred from mutant phenotype

(Kunduri et al., 2018)

inferred from genetic interaction with FLYBASE:Acox1; FB:FBgn0027572

(Chung et al., 2020)

inferred from direct assay

(Kwong et al., 2000, Mackay and Bewley, 1989)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables catalase activity

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR011614, InterPro:IPR018028, InterPro:IPR024708, InterPro:IPR024711, InterPro:IPR040333

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P04040

(Faust et al., 2012)

enables heme binding

inferred from electronic annotation with InterPro:IPR002226, InterPro:IPR011614, InterPro:IPR018028, InterPro:IPR020835, InterPro:IPR024711, InterPro:IPR040333

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(GO Reference Genome Project, 2011-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in heart morphogenesis

inferred from mutant phenotype

(Lim et al., 2014)

involved_in hydrogen peroxide catabolic process

inferred from genetic interaction with FLYBASE:Acox1; FB:FBgn0027572

(Chung et al., 2020)

involved_in intestinal stem cell homeostasis

inferred from mutant phenotype

(Wang et al., 2014)

involved_in paracrine signaling

inferred from mutant phenotype

(Lim et al., 2014)

involved_in reactive oxygen species metabolic process

inferred from mutant phenotype

(Lim et al., 2014)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

involved_in regulation of synaptic plasticity

inferred from mutant phenotype

(Oswald et al., 2018)

involved_in response to endoplasmic reticulum stress

inferred from mutant phenotype

(Wang et al., 2014)

involved_in response to hydrogen peroxide

inferred from mutant phenotype

(Sun and Tower, 1999)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

traceable author statement

(Helfand and Rogina, 2003, Boulianne, 2001, Longo, 1999)

involved_in hydrogen peroxide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR040333

(InterPro Project Members, 2004-)

involved_in response to hydrogen peroxide

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(GO Reference Genome Project, 2011-)

involved_in response to oxidative stress

inferred from electronic annotation with InterPro:IPR018028, InterPro:IPR024711, InterPro:IPR040333

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from direct assay

(Kwong et al., 2000)

located_in major mitochondrial derivative

inferred from direct assay

(Laurinyecz et al., 2019)

NOT is_active_in mitochondrion

inferred from direct assay

(Kwong et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(GO Reference Genome Project, 2011-)

is_active_in peroxisome

inferred from biological aspect of ancestor with PANTHER:PTN000157252

(GO Reference Genome Project, 2011-)

located_in peroxisome

inferred from sequence model

(Faust et al., 2012)

Gene Group (FlyBase)

CATALASES

Protein Family (UniProt)

Belongs to the catalase family. (P17336)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

catalase activity

2 H2O2 = O2 + 2 H2O (1.11.1.6)

RHEA 20309:

Summaries

Gene Snapshot

Gene Group (FlyBase)

CATALASES -: Catalases are members of oxidoreductase that prevent cell oxidative damage by degrading hydrogen peroxide to water and oxygen. (Adapted from PMID:19653683).

Protein Function (UniProtKB)

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.

(UniProt, P17336)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Cat: Catalase

The structural gene for catalase [CAT(EC 1.11.1.6)]. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut, and fat body; higher in adult abdomen than in thorax or head. Purification and characterization of enzyme by Nahmias and Bewley (1984, Comp. Biochem. Physiol. 77B: 355-64). Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P17336)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cat-RA

FBtr0075058

NM_080483

1993

506

Additional Transcript Data and Comments

Reported size (kB)

1.9-2.0 (northern blot)

(Orr et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cat-PA

FBpp0074825

57.1

506

8.30

P17336

NP_536731

AAF49228

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

506 (aa)

(Orr et al., 1990)

Comments

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P17336)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P17336

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cat using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cat_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.51

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

(Orr et al., 1990)

Additional Descriptive Data

Cat transcripts are detected in adult RNA.

(Orr et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc

(Santaren et al., 1993)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

foregut & midgut & hindgut | restricted

(Klichko et al., 2004)

embryonic stage 1 -- 6

organism

(Klichko et al., 2004)

embryonic stage 7 -- 17

embryonic/larval oenocyte precursor

(Klichko et al., 2004)

larval stage -- pupal stage

salivary gland

(Klichko et al., 2004)

larval stage -- adult stage

testis

(Klichko et al., 2004)

oenocyte

(Klichko et al., 2004)

fat body

(Klichko et al., 2004)

ovary

(Klichko et al., 2004)

adult stage

sense organ

(Klichko et al., 2004)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Cat enzyme activity is detected throughout development with peaks in late third instar just before puparium formation (at 96-100hr after egg deposition) and during metamorphosis at approx. 190 hours after egg deposition.

(Mackay and Bewley, 1989)

Cat enzyme activity is undetectable in the Catⁿ¹ mutant throughout development. Flies from the Catⁿ¹/Def(3L)Cat strain show no Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Catⁿ⁴/Df(3L)Cat flies have no detectable Cat enzyme activity and they show no Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

The level of Catenzyme activity in the Catⁿ² mutant was shown to be less than 10% ofwild type levels throughout development. There is a correspondingly lowlevel of Cat-specific cross-reacting material on Western blots of theCatⁿ²/Df(3L)Cat mutant.

(Mackay and Bewley, 1989)

Catⁿ³/Df(3L)Catand Catⁿ⁵/Df(3L)Cat flies have low levels of enzyme activity (<10%)and of Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Catⁿ⁶/Df(3L)Catflies have low levels of enzyme activity (<10%) and of Cat-specificcross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in cytosol

inferred from direct assay

(Kwong et al., 2000)

located_in major mitochondrial derivative

inferred from direct assay

(Laurinyecz et al., 2019)

NOT is_active_in mitochondrion

inferred from direct assay

(Kwong et al., 2000)

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}Cat^CPTI002786

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cat in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cat

View exonic expression by tissue for Dmel\Cat

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000261

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40048/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000261

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000261

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000261

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6871

Flygut - An atlas of the Drosophila adult midgut

FBgn0000261

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cat

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cat

Transgenic constructs containing regulatory region of Cat

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene not disrupted in

Df(3L)W4

(Spradling et al., 1999)

Df(3L)W10

(Spradling et al., 1999)

Gene disrupted in

Df(3L)Cat

(Orr et al., 1996, Wheeler et al., 1995, Harshman et al., 1991)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Cat^CC00907

lethal, with Scer\GAL4^Mef2.PR

Cat^KK101528

lethal (with Df(3L)BSC776)

Cat^{MI04522-TG4.0}

lethal | recessive

partially lethal | chemical conditional

partially lethal | chemical conditional, with Scer\GAL4^da.PU

Cat^GL01541

partially lethal - majority die

Catⁿ¹

partially lethal - majority die, with Scer\GAL4^Act.PU

Cat^{UAS.Tag:Mito(Oat)}

partially lethal - majority die, with Scer\GAL4^da.G32

Cat^{UAS.Tag:Mito(Oat)}

partially lethal - majority die, with Scer\GAL4^αTub84B.PL

Cat^{UAS.Tag:Mito(Oat)}

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cat^GD1291

viable, with Scer\GAL4^pnr-MD237

Cat^GD1291

viable, with Scer\GAL4^tin.CΔ4

Cat^GD1291

Sterility

Allele

fertile

Cat^e01301

Other Phenotypes

Allele

abnormal DNA repair | adult stage

Catⁿ¹

abnormal locomotor rhythm, with Scer\GAL4^tim.PE

Cat^GD1291

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav-C155

Cat^KK101528

abnormal oxidative stress response, with Scer\GAL4^Hand.PA

abnormal oxidative stress response, with Scer\GAL4^sns.GCN

Cat^UAS.cAa

abnormal oxidative stress response, with Scer\GAL4^Ugt36A1.PK

abnormal oxidative stress response, with Scer\GAL4^Ugt36A1.PK, Scer\GAL80^ts.αTub84B

Cat^UAS.cAa

abnormal stress response

Cat^UAS.cAa

chemical resistant

Cat^Act5C.PS

chemical resistant, with Scer\GAL4^da.PU

Cat^UAS.cAa

chemical sensitive

chemical sensitive, with Scer\GAL4^da.PU

Cat^GL01541

decreased cell number | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Cat^UAS.cAa

flightless, with Scer\GAL4^Mef2.PR

Cat^GD1291

increased occurrence of cell division | adult stage

Catⁿ¹

increased occurrence of cell division | adult stage | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

Cat^HMS00990

short lived

Catⁿ¹

visible, with Scer\GAL4^pnr-MD237

Cat^GD1291

wild-type

Cat^+t7

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^elav-C155

Cat^KK101528

adult fat body | adult stage, with Scer\GAL4^ppl.PU

Cat^RNAi.UAS.cUa

adult heart, with Scer\GAL4^sns.GCN

Cat^UAS.cAa

adult heart, with Scer\GAL4^Ugt36A1.PK

adult heart, with Scer\GAL4^Ugt36A1.PK, Scer\GAL80^ts.αTub84B

Cat^UAS.cAa

adult heart | progressive | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

Cat^GD1291

adult heart | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

Cat^UAS.cAa

adult midgut

Catⁿ¹

adult midgut | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

Cat^HMS00990

embryonic/larval plasmatocyte | adult stage, with Scer\GAL4^elav-C155

Cat^KK101528

enterocyte

Catⁿ¹

enteroendocrine cell | increased number

Catⁿ¹

follicle cell | somatic clone, with Scer\GAL4^Tub.PU

Cat^HMS00990

intestinal stem cell

Catⁿ¹

intestinal stem cell of posterior adult midgut epithelium

Catⁿ¹

lamellocyte | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Cat^UAS.cAa

lipid droplet | adult stage, with Scer\GAL4^ppl.PU

Cat^RNAi.UAS.cUa

mitochondrion | somatic clone, with Scer\GAL4^Tub.PU

Cat^HMS00990

trichogen cell, with Scer\GAL4^pnr-MD237

Cat^GD1291

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\CAT

14 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Cat

14 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Cat

13 of 14

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\cat.2

8 of 13

Yes

Xtro\cat.1

7 of 13

Yes

Xtro\cat.3

6 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\cat

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\ctl-1

14 of 14

Yes

Cele\ctl-2

14 of 14

Yes

Cele\ctl-3

13 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\CAT1

12 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\CAT1

9 of 13

Yes

Atha\CAT2

9 of 13

Yes

Atha\CAT3

9 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CTA1

13 of 13

Yes

Scer\CTT1

8 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ctt1

12 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\katE

9 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cat. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CatB

13 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Catⁿ¹

model of nephrolithiasis

CEA

(Na et al., 2024)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CAT; catalase

model of acatalasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Cat^HMS00990

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

exacerbates intestinal cancer

modeled by N^RNAi.P.UAS

(Chen et al., 2021)

Cat^GL01541

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^Aβ42.lexAop

(Stapper and Jahn, 2018)

Catⁿ¹

exacerbates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2011)

Cat^UAS.cAa

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Rival et al., 2009)

ameliorates Parkinson's disease

modeled by park²⁵

(Vincent et al., 2012)

DOES NOT ameliorate cancer

modeled by dlg1^HMS01954

(Bunker et al., 2015)

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib⁶⁷³

(Pérez et al., 2017)

modeled by Ras85D^Q13.UAS

(Tamamouna et al., 2021)

modeled by Raf^F22.hs

(Zhao et al., 2021)

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2011)

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates Mitchell syndrome

modeled by Acox1^N250S.UAS

(Chung et al., 2020)

Cat^UAS.cUa

ameliorates intestinal cancer

modeled by N^RNAi.P.UAS

(Chen et al., 2021)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Arctic.Aβ42.lexAop.Tag:SS(nec)}

(Hsieh and Chiang, 2023)

ameliorates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CAT; catalase

14 of 14

115500

ACATALASEMIA

acatalasia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cat - Acox1

two hybrid

(Hu et al., 2017.6.13)

Cat - CG16826

experimental knowledge based

(Guruharsha et al., 2011)

Cat - CG31343

experimental knowledge based

(Guruharsha et al., 2011)

Cat - Yp2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cat

suppressible

Gtpx

(Yang et al., 2013)

Cat

suppressible

Lsd-1

(Wang et al., 2021)

suppressible

(Lim et al., 2014)

suppressible

(Lim et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acox1

suppressible

Cat

(Chung et al., 2020)

Alkbh8

suppressible

Cat

(Madhwani et al., 2024)

Arms

suppressible

Cat

(Liao et al., 2023)

Cln3

suppressible

Cat

(Tuxworth et al., 2011)

cnc

suppressible

Cat

(Burbridge et al., 2021)

Creld

suppressible

Cat

(Paradis et al., 2022)

suppressible

(Xi et al., 2024)

suppressible

(Uttekar et al., 2024)

egr

suppressible

Cat

(Yang et al., 2013)

fbl

suppressible

Sod1|Cat|Trxr1

(Bosveld et al., 2008)

suppressible

Cat

(Edenharter et al., 2017, Navarro et al., 2011)

Gtpx

suppressible

Cat

(Yang et al., 2013)

htl

suppressible

Cat

(Dong et al., 2021)

Idh

suppressible

Cat

(Reitman et al., 2015)

Idh

enhanceable

Cat

(Reitman et al., 2015)

suppressible

(Ha et al., 2005)

suppressible

(Choo et al., 2015)

park

suppressible

Cat

(Vincent et al., 2012)

Ppcs

suppressible

Sod1|Cat|Trxr1

(Bosveld et al., 2008)

suppressible

(Xi et al., 2024)

suppressible

(Morey et al., 2001)

rod

suppressible

Sod2|Cat

(Clemente-Ruiz et al., 2016)

sev

suppressible

Cat

(Morey et al., 2001)

Tace

suppressible

Cat

(Muliyil et al., 2020)

suppressible

(Liu et al., 2022)

suppressible

(Vaccaro et al., 2020)

Trxr1

enhanceable

Cat

(Missirlis et al., 2001)

Trxr1

suppressible

Cat

(Missirlis et al., 2001)

vtd

suppressible

Cat

(Liu et al., 2015)

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P17336 )

Linkouts

BioGRID - A database of protein and genetic interactions.

65329

DroID - A comprehensive database of gene and protein interactions.

FBgn0000261

MIST (genetic) - An integrated Molecular Interaction Database

40048

MIST (protein-protein) - An integrated Molecular Interaction Database

40048

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

75E1-75E1

Sequence location

3L:18,822,604..18,828,188 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

75E1-75E1

Limits computationally determined from genome sequence between P{PZ}W⁰⁵⁰¹⁴ and P{lacW}l(3)j14E7^j14E7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

75D1-75E1

(determined by in situ hybridisation)

(Orr et al., 1996)

75D-75E

(determined by in situ hybridisation)

(Orr et al., 1990)

75D-76A

(determined by in situ hybridisation)

(Mackay et al., 1986)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-42.0

(Comeron et al., 2012)

(Choudhary et al., 1992)

3-47.0

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24621

w¹; P{UAS-Cat.A}2

607027

w^*; P{UAS-Cat.mt}8M

17939

w¹¹¹⁸; PBac{RB}Cat^e01301

81596

w^*; P{ST.lexA::HG}Cat^SE302

31894

y¹ v¹; P{TRiP.JF02173}attP2

37819

y¹ w^*; Mi{MIC}Cat^MI04522

60212

y¹ w^*; Mi{PT-GFSTF.0}Cat^{MI04522-GFSTF.0}

Kyoto

101586

Catⁿ⁴ / TM3, Sb¹ Ser¹

107554

Catⁿ¹ / TM3, Sb¹ Ser¹

115329

w¹¹¹⁸; PBac{768.FSVS-0}Cat^CPTI002786

VDRC

v103591

P{KK101528}VIE-260B

v6283

w¹¹¹⁸; P{GD1291}v6283

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (220)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE33242

Other clones

DPiM_RE33242

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000261

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000261

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per⁰¹, tim⁰¹ and Clk^Jrk background.

(Claridge-Chang et al., 2001)

Overexpression of Cat significantly increases resistance to hydrogen peroxide but has neutral or slightly deleterious effects on adult life span.

(Sun and Tower, 1999)

7kb Cat genomic fragment can provide functional rescue of the Cat mutant phenotype. Sequence elements that might be critical for the regulation of gene expression are identified by sequencing.

(Orr et al., 1996)

mRNA levels increase at adult day 5 in strain showing extended longevity phenotype (ELP).

(Dudas and Arking, 1995)

Some relationship exists between life span and antioxidant enzymes, the underlying mechanism of aging is not yet understood. Higher Cat activity is associated with reduced life span for e mutant.

(Durusoy et al., 1995)

Mutations in Cat or Sod can accelerate the induction of Hsp70 genes during aging.

(Wheeler et al., 1995)

Transgenic flies carrying three copies of Sod⁺ and three copies of Cat⁺ exhibited as much as one third extension of life span, a longer mortality rate doubling time, a lower amount of protein oxidative damage and a delayed loss in physical performance. Results support the free radical hypothesis of aging.

(Orr and Sohal, 1994)

Viability of acatalasemic flies can be restored by transformation with the wild type catalase gene. Though lack of catalase activity causes decreased viability and life span, increasing catalase activity above wild type levels had no effect on normal life span.

(Griswold et al., 1993)

Identification: Identified in 2D gels of CMW W2 wing imaginal disc cell proteins.

(Santaren et al., 1993)

Overexpression of Cat demonstrates enhanced levels of Cat does not prolong the life span, nor does it provide improved protection against oxidative stress induced by hyperoxia or paraquat treatment. It can provide enhanced resistance to hydrogen peroxide.

(Orr and Sohal, 1992)

D.melanogaster sensitivity to the deleterious effects of hydrogen peroxide increases when catalase activity is relatively low.

(Harshman et al., 1991)

The structural gene for catalase, a tetrameric enzyme. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut and fat body; higher in adult abdomen than in thorax or head. Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium. No electromorphs detected among 50 inbred laboratory strains.

(Nahmias and Bewley, 1984)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

CAT

(Liu et al., 2025, Wang et al., 2025, Yang et al., 2025, Yuan et al., 2025, Adeyemi et al., 2024, Chen et al., 2024, Chen et al., 2024, Fangninou et al., 2024, Ismaila et al., 2024, Kalra et al., 2024, Meichtry et al., 2024, Rehman and Khan, 2024, Wāng and Jiang, 2024, Wang et al., 2024, Yang et al., 2024, Bai et al., 2023, Fangninou et al., 2023, Ko et al., 2023, Yu et al., 2023, Alimba et al., 2022, Demir et al., 2022, Feng et al., 2022, Guo et al., 2022, Himalian et al., 2022, Huang et al., 2022, Musachio et al., 2022, Ogunsuyi et al., 2022, Wang et al., 2022, Wang et al., 2022, Cai et al., 2021, de Aquino Silva et al., 2021, Fernandes et al., 2021, Ge et al., 2021, Han et al., 2021, Janner et al., 2021, Jo et al., 2021, Johnson et al., 2021, Kayode et al., 2021, Ma et al., 2021, Musachio et al., 2021, Nanda and Firdaus, 2021, Portela et al., 2021, Silva et al., 2021, Yi et al., 2021, Yue et al., 2021, Zhang et al., 2021, Abtahi et al., 2020, Chen et al., 2020, Naz et al., 2020, Panchal and Tiwari, 2020, Saini et al., 2020, Vaccaro et al., 2020, Anet et al., 2019, Boulan et al., 2019, de Freitas Couto et al., 2019, Zhang et al., 2019, Anderson-Baron and Simmonds, 2018, Leite et al., 2018, Oboh et al., 2018, Occai et al., 2018, Poetini et al., 2018, Sharma et al., 2018, Zhang et al., 2018, Ecker et al., 2017, Macedo et al., 2017, Panchal and Tiwari, 2017, Rajak et al., 2017, Sonani et al., 2017, Subramanian et al., 2017, Wang et al., 2017, Adedara et al., 2016, Baron et al., 2016, Hu et al., 2016, Krishna and Muralidhara, 2016, Trindade de Paula et al., 2016, Wang et al., 2016, Araujo et al., 2015, Doganlar et al., 2015, Jahromi et al., 2015, Kim et al., 2015, Liu et al., 2015, Reitman et al., 2015, Wang et al., 2015, Zou et al., 2015, Prasad and Muralidhara, 2014, Valéria Soares de Araújo Pinho et al., 2014, Zhang et al., 2014, Huangfu et al., 2013, Sudati et al., 2013, Zuo et al., 2013, Dong et al., 2012, Zuo et al., 2012, Lushchak et al., 2011, Peng et al., 2011, Ahamed et al., 2010, Huang et al., 2010, Sanz et al., 2010, Singh et al., 2010, Rival et al., 2009, Siddique et al., 2008, Roesijadi et al., 2007, Gupta et al., 2005, Vontas et al., 2001, Arking, 1998, Arking et al., 1996, Gaivao and Comendador, 1996, Choudhary et al., 1992, Kawata et al., 1991)

CAT1

(Kang et al., 2023)

CATA

(Beghelli et al., 2024, Mushegian et al., 1998)

CG6871

(Murari et al., 2022, Ibaraki et al., 2021, Baron et al., 2016, Hosono et al., 2015, Kim et al., 2015, Rovenko et al., 2015, Faust et al., 2012, Faust et al., 2012, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Terhzaz et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Riedl et al., 2005, Pile et al., 2003)

CT21282

(Xie and Ding, 2000)

Cat

(Duneau et al., 2025, Geng et al., 2025, Klemm et al., 2025, Lennicke et al., 2025, Sun et al., 2025, Zhao et al., 2025, Alaraby et al., 2024, Dai et al., 2024, Dangabar Shadrack et al., 2024, Dark et al., 2024, Ganguly et al., 2024, Gaur et al., 2024, Hu et al., 2024, Kim et al., 2024, Li et al., 2024, Li et al., 2024, Meyer et al., 2024, Park et al., 2024, Rieder et al., 2024, Salminen et al., 2024, Sanusi et al., 2024, Scharenbrock et al., 2024, Siddique et al., 2024, Vesala et al., 2024, Zhu et al., 2024, Alaraby et al., 2023, Chen et al., 2023, De Lorenzi et al., 2023, Ham et al., 2023, He et al., 2023, Jin et al., 2023, Khalili et al., 2023, Nozawa et al., 2023, Shevchuk et al., 2023, Titlow et al., 2023, Tuo et al., 2023, Yamada et al., 2023, Yang et al., 2023, Alaraby et al., 2022, Climent-Cantó et al., 2022, Du et al., 2022, Fasae and Abolaji, 2022, Goyal et al., 2022, Keshav et al., 2022, Liu et al., 2022, Marcogliese et al., 2022, Murari et al., 2022, Palozzi et al., 2022, Yan et al., 2022, Alaraby et al., 2021, Cattenoz et al., 2021, Chen et al., 2021, Fabian et al., 2021, Girard et al., 2021, He et al., 2021, Ibaraki et al., 2021, Liang et al., 2021, Millet-Boureima et al., 2021, Shaposhnikov et al., 2021, Sheng et al., 2021, Shilpa et al., 2021, Watson et al., 2021, Wu et al., 2021, Yang et al., 2021, Chattopadhyay and Thirumurugan, 2020, Chen et al., 2020, Du et al., 2020, Huang et al., 2020, Jeon et al., 2020, Na et al., 2020, Park and Kim, 2020, Pridie et al., 2020, Rahul et al., 2020, Vásquez-Procopio et al., 2020, Alaraby et al., 2019, Bahhir et al., 2019, Barik and Mishra, 2019, Evangelakou et al., 2019, Hall et al., 2019, Hughes and Simmonds, 2019, Kockel et al., 2019, Laurinyecz et al., 2019, Li et al., 2019, Niraula and Kim, 2019, Riahi et al., 2019, Sanchez et al., 2019, Su et al., 2019, Toshniwal et al., 2019, Wang et al., 2019, Anderson-Baron and Simmonds, 2018, Calap-Quintana et al., 2018, Cara et al., 2018, Demir and Marcos, 2018, de Paula et al., 2018, Hill et al., 2018, Klimaczewski et al., 2018, Lee et al., 2018, Li et al., 2018, Liu et al., 2018, Niraula et al., 2018, Oberacker et al., 2018, Pinal et al., 2018, Sakakibara et al., 2018, Shaposhnikov et al., 2018, Staats et al., 2018, Stapper and Jahn, 2018, Hu et al., 2017.6.13, Jo and Imm, 2017, Suh et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Kučerová et al., 2016, Kuleesha et al., 2016, Adedara et al., 2015, Calap-Quintana et al., 2015, Carnes et al., 2015, Gene Disruption Project members, 2015-, Icreverzi et al., 2015, Park et al., 2015, Rovenko et al., 2015, Rovenko et al., 2015, Santabárbara-Ruiz et al., 2015, Terhzaz et al., 2015, Van Bortle et al., 2015, Wang et al., 2015, Zhai et al., 2015, Gao et al., 2014, Kim and Johnson, 2014, Lim et al., 2014, Logan-Garbisch et al., 2014, Tricoire et al., 2014, Wang et al., 2014, Mishra et al., 2013, Soh et al., 2013, Yang et al., 2013, Gurudatta et al., 2012, Hirano et al., 2012, Mandilaras and Missirlis, 2012, Monnier et al., 2012, Monnier et al., 2012, Peng et al., 2012, Pezzulo et al., 2012, Friedman et al., 2011, Navarro et al., 2011, Sinenko et al., 2011, Wang et al., 2011, Heifetz and Rivlin, 2010, Liu and Lu, 2010, Mockett et al., 2010, Radyuk et al., 2010, Sinenko et al., 2010, Wasbrough et al., 2010, Gruenewald et al., 2009, Peng et al., 2009, Anderson et al., 2008, Bosveld et al., 2008, Choi et al., 2008, Buszczak et al., 2007, Hueber et al., 2007, Dierick and Greenspan, 2006, Dorus et al., 2006, Anderson et al., 2005, Geiger-Thornsberry and Mackay, 2004, Park et al., 2004, Missirlis et al., 2003, Morey et al., 2003)

Cat-A

(Joy et al., 2021)

CatA

(Klotz et al., 1997)

DMCATHPO

(Fernando Vazquez et al., 2000, Colson and Goldstein, 1999, Lopez et al., 1999, Schug et al., 1997)

DROCATHPO

(Schug et al., 1998)

DmCAT

(Liu et al., 2017)

U00145

(Ptak and Petrov, 2002)

bs36h11.y1

(Andrews et al., 2000)

catalase

(Fogarty et al., 2016, Zhang et al., 2016, Mockett et al., 2003)

dCAT

(Murari et al., 2022)

dCat

(Murari et al., 2022)

Name Synonyms

CATHPO

(Colson and Goldstein, 1999)

Catalase

(Fei et al., 2025, Hirooka et al., 2025, Hunter-Manseau et al., 2025, Huang et al., 2024, Kim et al., 2024, Li et al., 2024, Tsuji et al., 2024, Wu et al., 2024, Eickelberg et al., 2022, Escobedo et al., 2022, Evans et al., 2022, Chen et al., 2021, Chen et al., 2021, Habib et al., 2021, Oboh et al., 2021, Pant et al., 2021, Abolaji et al., 2020, Chung et al., 2020, Fujisawa et al., 2020, Hill et al., 2020, Olufs et al., 2020, Paithankar et al., 2020, Pradhan et al., 2020, Deepashree et al., 2019, Duavy et al., 2019, Portela et al., 2019, Anderson-Baron and Simmonds, 2018, Cara et al., 2018, Kunduri et al., 2018, Leite et al., 2018, Niveditha and Shivanandappa, 2018, Occai et al., 2018, Saraiva et al., 2018, Pérez et al., 2017, Tan et al., 2017, Wang et al., 2017, Chen et al., 2016, Wang et al., 2016, Carnes et al., 2015, Choo et al., 2015, Icreverzi et al., 2015, Jahromi et al., 2015, Krucek et al., 2015, Nagarkar-Jaiswal et al., 2015, Santabárbara-Ruiz et al., 2015, Zhai et al., 2015, Gao et al., 2014, Lim et al., 2014, Logan-Garbisch et al., 2014, Muliyil and Narasimha, 2014, Ternes et al., 2014, Tricoire et al., 2014, Wang et al., 2014, Hirano et al., 2012, Mandilaras and Missirlis, 2012, Monnier et al., 2012, Rincon-Limas et al., 2012, Sun et al., 2012, Vincent et al., 2012, Cammarato et al., 2011, Lushchak et al., 2011, Peng et al., 2011, Sinenko et al., 2011, Ahamed et al., 2010, Barnes et al., 2010, Besson et al., 2010, Gao et al., 2010, Heifetz and Rivlin, 2010, Sanz et al., 2010, Sinenko et al., 2010, Terhzaz et al., 2010, List et al., 2009, Bhargav et al., 2008, Siddique et al., 2008, Gutierrez et al., 2007, Lai et al., 2007, Southall et al., 2006, Geiger-Thornsberry and Mackay, 2004)

SOD

(Bayliak et al., 2020)

catalase

(Yankuzo et al., 2025, Madhwani et al., 2024, Yu et al., 2023, Baek et al., 2022, Paradis et al., 2022, Strilbytska et al., 2022, Tian et al., 2022, Li et al., 2020, Matsumura et al., 2020, Muliyil et al., 2020, Wong et al., 2020, Lim et al., 2019, Weavers et al., 2019, Zhang et al., 2019, Romey-Glüsing et al., 2018, Soares et al., 2018, Louradour et al., 2017, Panchal and Tiwari, 2017, Fogarty et al., 2016, Krishna and Muralidhara, 2016, Zhang et al., 2016, Abolaji et al., 2015, Chen et al., 2015, Fan et al., 2015, Guntur et al., 2015, Liu et al., 2015, Reitman et al., 2015, Zou et al., 2015, Haddadi et al., 2014, Kim and Johnson, 2014, Lye et al., 2014, Medina-Leendertz et al., 2014, Mora et al., 2014, Olalekan Abolaji et al., 2014, Wang et al., 2014, Zemolin et al., 2014, Ayyaz and Jasper, 2013, Breckels et al., 2013, Clancy and Birdsall, 2013, Haddadi et al., 2013, Jahromi et al., 2013, Kim et al., 2013, Lozinsky et al., 2013, Owusu-Ansah et al., 2013, Dong et al., 2012, Iliadi et al., 2012, Sun et al., 2012, Zhao et al., 2012, Boyd et al., 2011, Tuxworth et al., 2011, Vrailas-Mortimer et al., 2011, Huang et al., 2010, Lee et al., 2010, Lloyd and Taylor, 2010, Mockett et al., 2010, Park et al., 2010, Sanz et al., 2010, Tohyama and Yamaguchi, 2010, Tsuda et al., 2010, Rival et al., 2009, Schriner et al., 2009, Bosveld et al., 2008, Choi et al., 2008, Krishnan et al., 2008, Li et al., 2008, Li et al., 2008, Wang et al., 2008, Carlson and Derr, 2007, Soh et al., 2007, Bayne et al., 2005, Gupta et al., 2005, Park et al., 2004, Helfand and Rogina, 2003, Morey et al., 2003, Mandavilli et al., 2002, Orr et al., 2000, Mockett et al., 1999, Colson, 1998.5.26, Colson, 1998.5.26, Mahafey, 1993.10.7, Orr, 1993.8.3)

cytosolic catalase

(Longo, 1999)

Secondary FlyBase IDs

FBgn0011460
FBgn0026841

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40048

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P17336

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P17336

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P17336

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000261

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40048/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000261

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000261

FlyMine - An integrated database for Drosophila genomics

FBgn0000261

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6871

MARRVEL_MODEL - MARRVEL (model organism gene)

40048

Linkouts

BioGRID - A database of protein and genetic interactions.

65329

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000261

DroID - A comprehensive database of gene and protein interactions.

FBgn0000261

DRSC - Results frm RNAi screens

FBgn0000261

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cat_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000261

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000261

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6871

Flygut - An atlas of the Drosophila adult midgut

FBgn0000261

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000261

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

40048

MIST (protein-protein) - An integrated Molecular Interaction Database

40048

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (648)

The following external sites may use different assemblies or annotations than FlyBase.

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