FlyBase Gene Report: Dmel\Cat

General Information

Symbol

Dmel\Cat

Species

D. melanogaster

Name

Catalase

Annotation Symbol

CG6871

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000261

Gene Model Status

Current

Stock Availability

18 publicly available

Gene Snapshot

Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. [Date last reviewed: 2018-09-06]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

DMCATHPO

Key Links

Genomic Location

Cytogenetic map

75E1-75E1

Sequence location

3L:18,822,604..18,828,188 [+]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:18822604..18828188

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables catalase activity

inferred from direct assay

(Mackay and Bewley, 1989)

inferred from genetic interaction with FLYBASE:ACOX1; FB:FBgn0027572

(Chung et al., 2020)

inferred from mutant phenotype

(Kunduri et al., 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables catalase activity

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:1516

(Faust et al., 2012)

enables heme binding

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (12 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in heart morphogenesis

inferred from mutant phenotype

(Lim et al., 2014)

involved_in hydrogen peroxide catabolic process

inferred from genetic interaction with FLYBASE:ACOX1; FB:FBgn0027572

(Chung et al., 2020)

involved_in intestinal stem cell homeostasis

inferred from mutant phenotype

(Wang et al., 2014)

involved_in paracrine signaling

inferred from mutant phenotype

(Lim et al., 2014)

involved_in reactive oxygen species metabolic process

inferred from mutant phenotype

(Lim et al., 2014)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

involved_in regulation of synaptic plasticity

inferred from mutant phenotype

(assigned by UniProt )

(Oswald et al., 2018)

involved_in response to endoplasmic reticulum stress

inferred from mutant phenotype

(Wang et al., 2014)

involved_in response to hydrogen peroxide

inferred from mutant phenotype

(Sun and Tower, 1999)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in aging

traceable author statement

(Luckinbill and Foley, 2000)

involved_in determination of adult lifespan

traceable author statement

(Helfand and Rogina, 2003, Boulianne, 2001, Longo, 1999)

involved_in hydrogen peroxide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in oxidation-reduction process

inferred from electronic annotation with InterPro:IPR011614, InterPro:IPR018028, InterPro:IPR020835, InterPro:IPR024711

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in response to hydrogen peroxide

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000157250

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000157252

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in peroxisome

inferred from biological aspect of ancestor with PANTHER:PTN000157252

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:1516

(Faust et al., 2012)

inferred from sequence model

(Faust et al., 2012)

Gene Group (FlyBase)

CATALASES

Protein Family (UniProt)

Belongs to the catalase family. (P17336)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CATALASES -: Catalases are members of oxidoreductase that prevent cell oxidative damage by degrading hydrogen peroxide to water and oxygen. (Adapted from PMID:19653683).

Protein Function (UniProtKB)

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

(UniProt, P17336)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Cat: Catalase

The structural gene for catalase [CAT(EC 1.11.1.6)]. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut, and fat body; higher in adult abdomen than in thorax or head. Purification and characterization of enzyme by Nahmias and Bewley (1984, Comp. Biochem. Physiol. 77B: 355-64). Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cat for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cat-RA

FBtr0075058

NM_080483

1993

506

Additional Transcript Data and Comments

Reported size (kB)

1.9-2.0 (northern blot)

(Orr et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cat-PA

FBpp0074825

57.1

506

8.30

NP_536731

AAF49228

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

506 (aa)

(Orr et al., 1990)

Comments

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P17336)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P17336

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cat using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cat_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

(Orr et al., 1990)

Additional Descriptive Data

Cat transcripts are detected in adult RNA.

(Orr et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc

(Santaren et al., 1993)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- pupal stage

salivary gland

(Klichko et al., 2004)

larval stage -- adult stage

testis

(Klichko et al., 2004)

oenocyte

(Klichko et al., 2004)

fat body

(Klichko et al., 2004)

ovary

(Klichko et al., 2004)

embryonic stage -- adult stage

foregut & midgut & hindgut | restricted

(Klichko et al., 2004)

adult stage

sense organ

(Klichko et al., 2004)

embryonic stage 1 -- 6

organism

(Klichko et al., 2004)

embryonic stage 7 -- 17

embryonic/larval oenocyte precursor

(Klichko et al., 2004)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010, Dorus et al., 2006)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Cat enzyme activity is detected throughout development with peaks in late third instar just before puparium formation (at 96-100hr after egg deposition) and during metamorphosis at approx. 190 hours after egg deposition.

(Mackay and Bewley, 1989)

Cat enzyme activity is undetectable in the Catⁿ¹ mutant throughout development. Flies from the Catⁿ¹/Def(3L)Cat strain show no Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Catⁿ⁴/Df(3L)Cat flies have no detectable Cat enzyme activity and they show no Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

The level of Catenzyme activity in the Catⁿ² mutant was shown to be less than 10% ofwild type levels throughout development. There is a correspondingly lowlevel of Cat-specific cross-reacting material on Western blots of theCatⁿ²/Df(3L)Cat mutant.

(Mackay and Bewley, 1989)

Catⁿ³/Df(3L)Catand Catⁿ⁵/Df(3L)Cat flies have low levels of enzyme activity (<10%)and of Cat-specific cross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Catⁿ⁶/Df(3L)Catflies have low levels of enzyme activity (<10%) and of Cat-specificcross-reacting material on Western blots.

(Mackay and Bewley, 1989)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}Cat^CPTI002786

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cat in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cat

View exonic expression by tissue for Dmel\Cat

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000261

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000261

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6871-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6871

Flygut - An atlas of the Drosophila adult midgut

FBgn0000261

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cat

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 15 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cat

Transgenic constructs containing regulatory region of Cat

Deletions and Duplications ( 3 )

Not disrupted in

Df(3L)W4

(Spradling et al., 1999)

Df(3L)W10

(Spradling et al., 1999)

Disrupted in

Df(3L)Cat

(Orr et al., 1996, Wheeler et al., 1995, Harshman et al., 1991)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Cat^CC00907

lethal (with Df(3L)BSC776)

Cat^{MI04522-TG4.0}

lethal | recessive

partially lethal | chemical conditional

partially lethal | chemical conditional, with Scer\GAL4^da.PU

Cat^GL01541

partially lethal - majority die

Catⁿ¹

partially lethal - majority die, with Scer\GAL4^Act.PU

Cat^{UAS.Tag:Mito(Oat)}

partially lethal - majority die, with Scer\GAL4^da.G32

Cat^{UAS.Tag:Mito(Oat)}

partially lethal - majority die, with Scer\GAL4^αTub84B.PL

Cat^{UAS.Tag:Mito(Oat)}

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cat^GD1291

viable, with Scer\GAL4^pnr-MD237

Cat^GD1291

viable, with Scer\GAL4^tin.CΔ4

Cat^GD1291

Sterility

Allele

fertile

Cat^e01301

Other Phenotypes

Allele

chemical resistant

Cat^Act5C.PS

chemical resistant, with Scer\GAL4^da.PU

Cat^UAS.cAa

chemical sensitive

chemical sensitive, with Scer\GAL4^da.PU

Cat^GL01541

decreased cell number | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Cat^UAS.cAa

DNA repair defective | adult stage

Catⁿ¹

flightless, with Scer\GAL4^Mef2.PR

Cat^GD1291

increased occurrence of cell division | adult stage

Catⁿ¹

locomotor rhythm defective, with Scer\GAL4^tim.PE

Cat^GD1291

neuroanatomy defective | adult stage, with Scer\GAL4^elav-C155

Cat^KK101528

oxidative stress response defective, with Scer\GAL4^Hand.PA

oxidative stress response defective, with Scer\GAL4^sns.GCN

Cat^UAS.cAa

oxidative stress response defective, with Scer\GAL4^Ugt36A1.PK

oxidative stress response defective, with Scer\GAL4^Ugt36A1.PK, Scer\GAL80^ts.αTub84B

Cat^UAS.cAa

short lived

Catⁿ¹

stress response defective

Cat^UAS.cAa

visible, with Scer\GAL4^pnr-MD237

Cat^GD1291

wild-type

Cat^+t7

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^elav-C155

Cat^KK101528

adult heart, with Scer\GAL4^sns.GCN

Cat^UAS.cAa

adult heart, with Scer\GAL4^Ugt36A1.PK

adult heart, with Scer\GAL4^Ugt36A1.PK, Scer\GAL80^ts.αTub84B

Cat^UAS.cAa

adult heart | progressive | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

Cat^GD1291

adult heart | RU486 conditional, with Scer\GAL4^{Hand.ΔVM.Switch}

Cat^UAS.cAa

adult midgut

Catⁿ¹

enterocyte

Catⁿ¹

enteroendocrine cell | supernumerary

Catⁿ¹

intestinal stem cell

Catⁿ¹

intestinal stem cell of posterior adult midgut epithelium

Catⁿ¹

lamellocyte | third instar larval stage | conditional, with Scer\GAL4^Antp-10

Cat^UAS.cAa

plasmatocyte | adult stage, with Scer\GAL4^elav-C155

Cat^KK101528

trichogen cell, with Scer\GAL4^pnr-MD237

Cat^GD1291

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CAT

14 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cat

13 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Cat

13 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cat.2

13 of 12

Yes

Xtro\cat.1

9 of 12

Yes

Xtro\cat.3

2 of 12

Yes

Xtro\LOC100494804

2 of 12

Yes

Danio rerio (Zebrafish) (1)

Drer\cat

13 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\ctl-1

14 of 15

Yes

Cele\ctl-3

13 of 15

Cele\ctl-2

12 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\CAT1

6 of 9

Yes

Atha\CAT2

6 of 9

Yes

Atha\CAT3

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CTA1

13 of 15

Yes

Scer\CTT1

7 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ctt1

11 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905IK )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00011806

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19920

Drosophila willistoni

Dwil\GK12121

Drosophila virilis

Dvir\GJ11574

Drosophila mojavensis

Dmoj\GI11318

Drosophila grimshawi

Dgri\GH14374

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915035H )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17023657

Glossina morsitans

Tsetse fly

Gmor\GMOY004149

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03458

Mayetiola destructor

Hessian fly

Mdes\Mdes000123

Aedes aegypti

Yellow fever mosquito

Aaeg\CAT1B

Anopheles darlingi

American malaria mosquito

Adar\ADAC006955

Anopheles gambiae

Malaria mosquito

Agam\CAT1

Culex quinquefasciatus

Southern house mosquito

Cqui\cat

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W052O )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000701

Danaus plexippus

Monarch butterfly

Dple\DPOGS209670-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008463

Apis florea

Little honeybee

Aflo\2147521155

Apis florea

Little honeybee

Aflo\2147490945

Apis florea

Little honeybee

Aflo\2147488225

Apis mellifera

Western honey bee

Amel\GB41427

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21511

Bombus terrestris

Buff-tailed bumblebee

Bter\15211246

Linepithema humile

Argentine ant

Lhum\LH22009

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002ea5

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013138

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06817

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08942

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00298

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00139

Tribolium castaneum

Red flour beetle

Tcas\TC011090

Tribolium castaneum

Red flour beetle

Tcas\TC034503

Tribolium castaneum

Red flour beetle

Tcas\TC011385

Pediculus humanus

Human body louse

Phum\PHUM336860

Rhodnius prolixus

Kissing bug

Rpro\RPRC007468

Rhodnius prolixus

Kissing bug

Rpro\RPRC007347

Rhodnius prolixus

Kissing bug

Rpro\RPRC007907

Rhodnius prolixus

Kissing bug

Rpro\RPRC009934

Cimex lectularius

Bed bug

Clec\CLEC000120

Cimex lectularius

Bed bug

Clec\CLEC009294

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001032

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14467

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_14466

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01442

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04ES )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005224

Ixodes scapularis

Black-legged tick

Isca\ISCW017124

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80301.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur23g01370

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g01500

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g09890

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g09370

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04V5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cat

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005187

Gallus gallus

Domestic chicken

Ggal\CAT

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

8 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CAT; catalase

model of acatalasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Cat^GL01541

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^Aβ42.lexAop

(Stapper and Jahn, 2018)

Catⁿ¹

exacerbates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2011)

Cat^UAS.cAa

ameliorates Parkinson's disease

modeled by park²⁵

(Vincent et al., 2012)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Rival et al., 2009)

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates Alexander disease

modeled by Hsap\GFAP^R79H.UAS

(Wang et al., 2011)

DOES NOT ameliorate cancer

modeled by dlg1^HMS01954

(Bunker et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CAT; catalase

14 of 15

115500

ACATALASEMIA

acatalasia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cat - ACOX1

two hybrid

(Hu et al., 2017.6.13)

Cat - CG16826

experimental knowledge based

(Guruharsha et al., 2011)

Cat - CG31343

experimental knowledge based

(Guruharsha et al., 2011)

Cat - Yp2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lim et al., 2014)

suppressible

(Lim et al., 2014)

suppressible

(Yang et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cln3

suppressible

Cat

(Tuxworth et al., 2011)

egr

suppressible

Cat

(Yang et al., 2013)

fbl

suppressible

Cat|Sod1|Trxr-1

(Bosveld et al., 2008)

suppressible

Cat

(Edenharter et al., 2017, Navarro et al., 2011)

Idh

suppressible

Cat

(Reitman et al., 2015)

Idh

enhanceable

Cat

(Reitman et al., 2015)

suppressible

(Ha et al., 2005)

suppressible

(Vincent et al., 2012)

PHGPx

suppressible

Cat

(Yang et al., 2013)

Ppcs

suppressible

Cat|Sod1|Trxr-1

(Bosveld et al., 2008)

Raf::tor

suppressible

Cat

(Morey et al., 2001)

sev

suppressible

Cat

(Morey et al., 2001)

Trxr-1

enhanceable

Cat

(Missirlis et al., 2001)

vtd

suppressible

Cat

(Liu et al., 2015)

External Data

Subunit Structure (UniProtKB)

Homotetramer.

(UniProt, P17336 )

Linkouts

BioGRID - A database of protein and genetic interactions.

65329

DroID - A comprehensive database of gene and protein interactions.

FBgn0000261

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40048

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

75E1-75E1

Sequence location

3L:18,822,604..18,828,188 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

75E1-75E1

Limits computationally determined from genome sequence between P{PZ}W⁰⁵⁰¹⁴ and P{lacW}l(3)j14E7^j14E7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

75D1-75E1

(determined by in situ hybridisation)

(Orr et al., 1996)

75D-75E

(determined by in situ hybridisation)

(Orr et al., 1990)

75D-76A

(determined by in situ hybridisation)

(Mackay et al., 1986)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-42.0

(Comeron et al., 2012)

(Choudhary et al., 1992)

3-47.0

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Bloomington

24621

w¹; P{UAS-Cat.A}2

17939

w¹¹¹⁸; PBac{RB}Cat^e01301

81596

w^*; P{ST.lexA::HG}Cat^SE302

31894

y¹ v¹; P{TRiP.JF02173}attP2

4014

Catⁿ¹/TM3, Sb¹ Ser¹

37819

y¹ w^*; Mi{MIC}Cat^MI04522

60212

y¹ w^*; Mi{PT-GFSTF.0}Cat^{MI04522-GFSTF.0}

Kyoto

101586

Catⁿ⁴ / TM3, Sb¹ Ser¹

107554

Catⁿ¹ / TM3, Sb¹ Ser¹

115329

w¹¹¹⁸; PBac{768.FSVS-0}Cat^CPTI002786

VDRC

v103591

P{KK101528}VIE-260B

v6283

w¹¹¹⁸; P{GD1291}v6283

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (222)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE33242

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000261

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000261

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40048

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per⁰¹, tim⁰¹ and Clk^Jrk background.

(Claridge-Chang et al., 2001)

Overexpression of Cat significantly increases resistance to hydrogen peroxide but has neutral or slightly deleterious effects on adult life span.

(Sun and Tower, 1999)

7kb Cat genomic fragment can provide functional rescue of the Cat mutant phenotype. Sequence elements that might be critical for the regulation of gene expression are identified by sequencing.

(Orr et al., 1996)

mRNA levels increase at adult day 5 in strain showing extended longevity phenotype (ELP).

(Dudas and Arking, 1995)

Some relationship exists between life span and antioxidant enzymes, the underlying mechanism of aging is not yet understood. Higher Cat activity is associated with reduced life span for e mutant.

(Durusoy et al., 1995)

Mutations in Cat or Sod can accelerate the induction of Hsp70 genes during aging.

(Wheeler et al., 1995)

Transgenic flies carrying three copies of Sod⁺ and three copies of Cat⁺ exhibited as much as one third extension of life span, a longer mortality rate doubling time, a lower amount of protein oxidative damage and a delayed loss in physical performance. Results support the free radical hypothesis of aging.

(Orr and Sohal, 1994)

Viability of acatalasemic flies can be restored by transformation with the wild type catalase gene. Though lack of catalase activity causes decreased viability and life span, increasing catalase activity above wild type levels had no effect on normal life span.

(Griswold et al., 1993)

Identification: Identified in 2D gels of CMW W2 wing imaginal disc cell proteins.

(Santaren et al., 1993)

Overexpression of Cat demonstrates enhanced levels of Cat does not prolong the life span, nor does it provide improved protection against oxidative stress induced by hyperoxia or paraquat treatment. It can provide enhanced resistance to hydrogen peroxide.

(Orr and Sohal, 1992)

D.melanogaster sensitivity to the deleterious effects of hydrogen peroxide increases when catalase activity is relatively low.

(Harshman et al., 1991)

The structural gene for catalase, a tetrameric enzyme. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut and fat body; higher in adult abdomen than in thorax or head. Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium. No electromorphs detected among 50 inbred laboratory strains.

(Nahmias and Bewley, 1984)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40048

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P17336

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000261

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000261

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cat_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6871

Flygut - An atlas of the Drosophila adult midgut

FBgn0000261

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40048

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034503

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6871

modMine - A data warehouse for the modENCODE project

FBgn0000261

Linkouts

BioGRID - A database of protein and genetic interactions.

65329

DPiM - Drosophila Protein interaction map

FBgn0000261

DroID - A comprehensive database of gene and protein interactions.

FBgn0000261

DRSC - Results frm RNAi screens

FBgn0000261

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0000261

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG6871-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000261

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

FlyMine - An integrated database for Drosophila genomics

FBgn0000261

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40048

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

CAT

(Abtahi et al., 2020, Chen et al., 2020, Naz et al., 2020, Panchal and Tiwari, 2020, Saini et al., 2020, Anet et al., 2019, Boulan et al., 2019, de Freitas Couto et al., 2019, Zhang et al., 2019, Anderson-Baron and Simmonds, 2018, Leite et al., 2018, Oboh et al., 2018, Occai et al., 2018, Poetini et al., 2018, Sharma et al., 2018, Zhang et al., 2018, Ecker et al., 2017, Macedo et al., 2017, Panchal and Tiwari, 2017, Rajak et al., 2017, Sonani et al., 2017, Subramanian et al., 2017, Wang et al., 2017, Adedara et al., 2016, Baron et al., 2016, Hu et al., 2016, Krishna and Muralidhara, 2016, Trindade de Paula et al., 2016, Wang et al., 2016, Araujo et al., 2015, Doganlar et al., 2015, Jahromi et al., 2015, Kim et al., 2015, Liu et al., 2015, Reitman et al., 2015, Wang et al., 2015, Zou et al., 2015, Prasad and Muralidhara, 2014, Valéria Soares de Araújo Pinho et al., 2014, Zhang et al., 2014, Huangfu et al., 2013, Sudati et al., 2013, Zuo et al., 2013, Dong et al., 2012, Zuo et al., 2012, Lushchak et al., 2011, Peng et al., 2011, Ahamed et al., 2010, Huang et al., 2010, Sanz et al., 2010, Singh et al., 2010, Rival et al., 2009, Siddique et al., 2008, Roesijadi et al., 2007, Gupta et al., 2005, Vontas et al., 2001, Arking, 1998, Arking et al., 1996, Gaivao and Comendador, 1996, Choudhary et al., 1992, Kawata et al., 1991)

CATA

(Mushegian et al., 1998)

CG6871

(Baron et al., 2016, Hosono et al., 2015, Kim et al., 2015, Rovenko et al., 2015, Faust et al., 2012, Faust et al., 2012, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Terhzaz et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Riedl et al., 2005, Pile et al., 2003)

CT21282

(Xie and Ding, 2000)

Cat

(Chattopadhyay and Thirumurugan, 2020, Chen et al., 2020, Huang et al., 2020, Na et al., 2020, Park and Kim, 2020, Rahul et al., 2020, Vásquez-Procopio et al., 2020, Alaraby et al., 2019, Bahhir et al., 2019, Barik and Mishra, 2019, Evangelakou et al., 2019, Hall et al., 2019, Hughes and Simmonds, 2019, Kockel et al., 2019, Laurinyecz et al., 2019, Li et al., 2019, Niraula and Kim, 2019, Riahi et al., 2019, Sanchez et al., 2019, Su et al., 2019, Toshniwal et al., 2019, Wang et al., 2019, Anderson-Baron and Simmonds, 2018, Calap-Quintana et al., 2018, Cara et al., 2018, Demir and Marcos, 2018, de Paula et al., 2018, Hill et al., 2018, Klimaczewski et al., 2018, Lee et al., 2018, Li et al., 2018, Liu et al., 2018, Niraula et al., 2018, Oberacker et al., 2018, Pinal et al., 2018, Sakakibara et al., 2018, Shaposhnikov et al., 2018, Staats et al., 2018, Stapper and Jahn, 2018, Hu et al., 2017.6.13, Jo and Imm, 2017, Suh et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Kučerová et al., 2016, Kuleesha et al., 2016, Adedara et al., 2015, Calap-Quintana et al., 2015, Carnes et al., 2015, Gene Disruption Project members, 2015-, Icreverzi et al., 2015, Park et al., 2015, Rovenko et al., 2015, Rovenko et al., 2015, Santabárbara-Ruiz et al., 2015, Terhzaz et al., 2015, Van Bortle et al., 2015, Zhai et al., 2015, Gao et al., 2014, Kim and Johnson, 2014, Lim et al., 2014, Logan-Garbisch et al., 2014, Tricoire et al., 2014, Wang et al., 2014, Mishra et al., 2013, Soh et al., 2013, Yang et al., 2013, Gurudatta et al., 2012, Hirano et al., 2012, Mandilaras and Missirlis, 2012, Monnier et al., 2012, Monnier et al., 2012, Peng et al., 2012, Pezzulo et al., 2012, Friedman et al., 2011, Navarro et al., 2011, Sinenko et al., 2011, Wang et al., 2011, Heifetz and Rivlin, 2010, Liu and Lu, 2010, Mockett et al., 2010, Radyuk et al., 2010, Sinenko et al., 2010, Wasbrough et al., 2010, Gruenewald et al., 2009, Peng et al., 2009, Anderson et al., 2008, Bosveld et al., 2008, Choi et al., 2008, Buszczak et al., 2007, Hueber et al., 2007, Dierick and Greenspan, 2006, Dorus et al., 2006, Anderson et al., 2005, Geiger-Thornsberry and Mackay, 2004, Park et al., 2004, Missirlis et al., 2003, Morey et al., 2003)

CatA

(Klotz et al., 1997)

DMCATHPO

(Fernando Vazquez et al., 2000, Colson and Goldstein, 1999, Lopez et al., 1999, Schug et al., 1997)

DROCATHPO

(Schug et al., 1998)

DmCAT

(Liu et al., 2017)

U00145

(Ptak and Petrov, 2002)

bs36h11.y1

(Andrews et al., 2000)

cat

(Ma et al., 2020, Figueira et al., 2017, Guntur et al., 2015, Haddadi et al., 2014, Haddadi et al., 2013, Jahromi et al., 2013, Li et al., 2013, Iliadi et al., 2012, Boyd et al., 2011, Wayne et al., 2011, Gao et al., 2010, Tsuda et al., 2010, Wicks et al., 2009, Krishnan et al., 2008, Wang et al., 2008, Riedl et al., 2005, Luckinbill and Foley, 2000)

catalase

(Fogarty et al., 2016, Zhang et al., 2016, Mockett et al., 2003)

Name Synonyms

CATHPO

(Colson and Goldstein, 1999)

Catalase

(Abolaji et al., 2020, Chung et al., 2020, Fujisawa et al., 2020, Olufs et al., 2020, Paithankar et al., 2020, Pradhan et al., 2020, Deepashree et al., 2019, Duavy et al., 2019, Portela et al., 2019, Anderson-Baron and Simmonds, 2018, Cara et al., 2018, Kunduri et al., 2018, Leite et al., 2018, Niveditha and Shivanandappa, 2018, Occai et al., 2018, Saraiva et al., 2018, Pérez et al., 2017, Tan et al., 2017, Wang et al., 2017, Chen et al., 2016, Wang et al., 2016, Carnes et al., 2015, Icreverzi et al., 2015, Jahromi et al., 2015, Krucek et al., 2015, Nagarkar-Jaiswal et al., 2015, Santabárbara-Ruiz et al., 2015, Zhai et al., 2015, Gao et al., 2014, Lim et al., 2014, Logan-Garbisch et al., 2014, Muliyil and Narasimha, 2014, Tricoire et al., 2014, Wang et al., 2014, Hirano et al., 2012, Mandilaras and Missirlis, 2012, Monnier et al., 2012, Rincon-Limas et al., 2012, Sun et al., 2012, Vincent et al., 2012, Cammarato et al., 2011, Lushchak et al., 2011, Peng et al., 2011, Sinenko et al., 2011, Ahamed et al., 2010, Barnes et al., 2010, Besson et al., 2010, Gao et al., 2010, Heifetz and Rivlin, 2010, Sanz et al., 2010, Sinenko et al., 2010, Terhzaz et al., 2010, List et al., 2009, Bhargav et al., 2008, Siddique et al., 2008, Gutierrez et al., 2007, Lai et al., 2007, Southall et al., 2006, Geiger-Thornsberry and Mackay, 2004)

SOD

(Bayliak et al., 2020)

catalase

(Li et al., 2020, Matsumura et al., 2020, Muliyil et al., 2020, Lim et al., 2019, Zhang et al., 2019, Romey-Glüsing et al., 2018, Soares et al., 2018, Louradour et al., 2017, Panchal and Tiwari, 2017, Fogarty et al., 2016, Krishna and Muralidhara, 2016, Zhang et al., 2016, Abolaji et al., 2015, Chen et al., 2015, Fan et al., 2015, Guntur et al., 2015, Liu et al., 2015, Reitman et al., 2015, Zou et al., 2015, Haddadi et al., 2014, Kim and Johnson, 2014, Lye et al., 2014, Medina-Leendertz et al., 2014, Mora et al., 2014, Olalekan Abolaji et al., 2014, Wang et al., 2014, Zemolin et al., 2014, Ayyaz and Jasper, 2013, Breckels et al., 2013, Clancy and Birdsall, 2013, Haddadi et al., 2013, Jahromi et al., 2013, Kim et al., 2013, Lozinsky et al., 2013, Owusu-Ansah et al., 2013, Dong et al., 2012, Iliadi et al., 2012, Sun et al., 2012, Zhao et al., 2012, Boyd et al., 2011, Tuxworth et al., 2011, Vrailas-Mortimer et al., 2011, Huang et al., 2010, Lee et al., 2010, Lloyd and Taylor, 2010, Mockett et al., 2010, Park et al., 2010, Sanz et al., 2010, Tohyama and Yamaguchi, 2010, Tsuda et al., 2010, Rival et al., 2009, Schriner et al., 2009, Bosveld et al., 2008, Choi et al., 2008, Krishnan et al., 2008, Li et al., 2008, Li et al., 2008, Wang et al., 2008, Carlson and Derr, 2007, Soh et al., 2007, Bayne et al., 2005, Gupta et al., 2005, Park et al., 2004, Helfand and Rogina, 2003, Morey et al., 2003, Mandavilli et al., 2002, Orr et al., 2000, Mockett et al., 1999, Colson, 1998.5.26, Colson, 1998.5.26, Mahafey, 1993.10.7, Orr, 1993.8.3)

cytosolic catalase

(Longo, 1999)

Secondary FlyBase IDs

FBgn0011460
FBgn0026841

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (422)

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