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Gene Dmel\Cat

General Information
Symbol	Dmel\Cat	Species	D. melanogaster
Name	Catalase	Annotation symbol	CG6871
Feature type	protein_coding_gene	FlyBase ID	FBgn0000261
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	DMCATHPO, CATA
Genomic Location
Chromosome (arm)	3L	Recombination map	3-47.0
Cytogenetic map	75E1-75E1	Sequence location	3L:18,815,706..18,821,294 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Catalase is referred to in FlyBase by the symbol Dmel\Cat (CG6871, FBgn0000261). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: catalase activity. There is experimental evidence that it is involved in the biological process: response to hydrogen peroxide. 26 alleles are reported. The phenotypes of these alleles are annotated with: adult midgut; trichogen cell; intestinal stem cell; enterocyte. It has one annotated transcript and one annotated polypeptide. Protein features are: Catalase active site; Catalase domain; Catalase haem-binding site; Catalase, N-terminal; Catalase, mono-functional, haem-containing; Catalase, mono-functional, haem-containing, clades 1 and 3; Catalase-related immune responsive. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1639480_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cat. Gene sequence location is 3L:18815706..18821294.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cat: Catalase The structural gene for catalase [CAT(EC 1.11.1.6)]. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut, and fat body; higher in adult abdomen than in thorax or head. Purification and characterization of enzyme by Nahmias and Bewley (1984, Comp. Biochem. Physiol. 77B: 355-64). Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 Sequence features BKN21579 HFA11110
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 75E1-75E1   Limits computationally determined from genome sequence between P{PZ}W05014 and P{lacW}l(3)j14E7j14E7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 75D1-75E1   (determined by in situ hybridisation)   (Orr et al., 1996) 75D-75E   (determined by in situ hybridisation)   (Orr et al., 1990) 75D-76A   (determined by in situ hybridisation)   (Mackay et al., 1986)
Experimentally Determined Recombination Data
Location	3-47.0   3- (Choudhary et al., 1992)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cat for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cat-RA FBtr0075058  NM_080483   1997   506
Additional Transcript Data & Comments
Reported size (kB)	1.9-2.0 (northern blot) (Orr et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cat-PA   FBpp0074825   57.1   506   8.30     NP_536731   AAF49228
Additional Polypeptide Data & Comments
Reported size (kDa)	506 (aa) (Orr et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Catalase-related immune responsive (IPR010582) Catalase, mono-functional, haem-containing (IPR018028) Catalase haem-binding site (IPR002226) Catalase, N-terminal (IPR011614) Catalase domain (IPR020835) Catalase active site (IPR024708) Catalase, mono-functional, haem-containing, clades 1 and 3 (IPR024711)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391254   AA439232   AA540048   AA697348   AA978686   AE014296 AAF49228   AF067922   AF067923   AI062073   AI107490   AI135811   AI238770   AI238848   AI238958   AI257942   AI259712   AI293991   AI294296   AI296617   AI388653   AI402849   AI405935   AI455963   AI514772   AI517000   AI518190   AI542608   AI546678   AI947142   AI947262   AY084154 AAL89892   AY433680   BF493282   BF498803   BF499113   BF499174   BF499753   BF501041   BF502664   BG636793   BI164664   BI168764   BI235184   BI237084   BI243621   BI353921   BI370982   BI484328   BI486800   BI566309   BI566401   BI567090   BI574143   BI577417   BI582696   BI588836   BI605029   BI606247   BI613455   BI619014   BI622421   BI624773   BI626189   BI626775   BI627347   BI632922   BI634547   BI636183   BI637270   CA804104   CA807254   CA807764   CK657987   CK660145   CK660714   CK661025   CK662377   CO155285   CO155813   CO184804   CO188944   CO191861   CO193933   CO193970   CO286592   CO297830   CO306615   CO314597   CO316478   CO317101   CO322303   CO335649   CO336030   CZ479106   EC064307   EC069516   EC074117   EC076959   EC197908   EC203681   EC204105   EC211507   EC211925   EC214944   EC229451   EC238480   EC243748   EC244326   EC246500   EC248728   EC263858   EC266781   EL873602   EL873603   EV582636   EV598393   U00145 AAC13738   X52286 CAA36529   X74367
UniProtKB/Swiss-Prot	P17336
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage     (Orr et al., 1990)
Additional Descriptive Data
	Cat transcripts are detected in adult RNA. (Orr et al., 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   wing disc   (Santaren et al., 1993) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   foregut & midgut & hindgut | restricted   (Klichko et al., 2004) embryonic stage 1 -- 6   organism   (Klichko et al., 2004) embryonic stage 7 -- 17   embryonic/larval oenocyte precursor   (Klichko et al., 2004) larval stage -- pupal stage   salivary gland   (Klichko et al., 2004) larval stage -- adult stage   testis   (Klichko et al., 2004) oenocyte   (Klichko et al., 2004) fat body   (Klichko et al., 2004) ovary   (Klichko et al., 2004) adult stage   sense organ   (Klichko et al., 2004) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Cat enzyme activity is undetectable in the Catn1 mutant throughout development. Flies from the Catn1/Def(3L)Cat strain show no Cat-specific cross-reacting material on Western blots. (Mackay and Bewley, 1989) Catn6/Df(3L)Catflies have low levels of enzyme activity (<10%) and of Cat-specificcross-reacting material on Western blots. (Mackay and Bewley, 1989) Catn4/Df(3L)Cat flies have no detectable Cat enzyme activity and they show no Cat-specific cross-reacting material on Western blots. (Mackay and Bewley, 1989) Cat enzyme activity is detected throughout development with peaks in late third instar just before puparium formation (at 96-100hr after egg deposition) and during metamorphosis at approx. 190 hours after egg deposition. (Mackay and Bewley, 1989) Catn3/Df(3L)Catand Catn5/Df(3L)Cat flies have low levels of enzyme activity (<10%)and of Cat-specific cross-reacting material on Western blots. (Mackay and Bewley, 1989) The level of Catenzyme activity in the Catn2 mutant was shown to be less than 10% ofwild type levels throughout development. There is a correspondingly lowlevel of Cat-specific cross-reacting material on Western blots of theCatn2/Df(3L)Cat mutant. (Mackay and Bewley, 1989)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000261    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000261 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000261 expression level Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old    17389 larva L3 puffstage 1-2    27582 larva L3 puffstage 3-6    23374 larva L3 puffstage 7-9    26293 white prepupae new    43065 white prepupae 12hr    35288 white prepupae 24hr    32629 pupae 2d postWPP    31639 pupae 3d postWPP    23020 pupae 4d postWPP    18306 adult male 01day    33208 adult male 05day    38111 adult male 30day    31726 adult female 01day    17240 adult female 05day    11428 adult female 30day    12893 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2987) embryo 02-04hr  (3897) embryo 04-06hr  (2274) embryo 06-08hr  (2340) embryo 08-10hr  (3962) embryo 10-12hr  (5993) embryo 12-14hr  (3842) embryo 14-16hr  (6258) embryo 16-18hr  (6749) embryo 18-20hr  (6549) embryo 20-22hr  (4220) embryo 22-24hr  (4228) larva L1  (5400) larva L2  (9164) larva L3 12hr old  (17389) larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  (18306) adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  (17240) adult female 05day  (11428) adult female 30day  (12893) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2987) embryo 02-04hr  (3897) embryo 04-06hr  (2274) embryo 06-08hr  (2340) embryo 08-10hr  (3962) embryo 10-12hr  (5993) embryo 12-14hr  (3842) embryo 14-16hr  (6258) embryo 16-18hr  (6749) embryo 18-20hr  (6549) embryo 20-22hr  (4220) embryo 22-24hr  (4228) larva L1  (5400) larva L2  (9164) larva L3 12hr old  (17389) larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  (18306) adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  (17240) adult female 05day  (11428) adult female 30day  (12893) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old  (17389) larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  (18306) adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  (17240) adult female 05day  (11428) adult female 30day  (12893) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old    17389 larva L3 puffstage 1-2    27582 larva L3 puffstage 3-6    23374 larva L3 puffstage 7-9    26293 white prepupae new    43065 white prepupae 12hr    35288 white prepupae 24hr    32629 pupae 2d postWPP    31639 pupae 3d postWPP    23020 pupae 4d postWPP    18306 adult male 01day    33208 adult male 05day    38111 adult male 30day    31726 adult female 01day    17240 adult female 05day    11428 adult female 30day    12893 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000261 expression level Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old    17389 larva L3 puffstage 1-2    27582 larva L3 puffstage 3-6    23374 larva L3 puffstage 7-9    26293 white prepupae new    43065 white prepupae 12hr    35288 white prepupae 24hr    32629 pupae 2d postWPP    31639 pupae 3d postWPP    23020 pupae 4d postWPP    18306 adult male 01day    33208 adult male 05day    38111 adult male 30day    31726 adult female 01day    17240 adult female 05day    11428 adult female 30day    12893 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2987) embryo 02-04hr  (3897) embryo 04-06hr  (2274) embryo 06-08hr  (2340) embryo 08-10hr  (3962) embryo 10-12hr  (5993) embryo 12-14hr  (3842) embryo 14-16hr  (6258) embryo 16-18hr  (6749) embryo 18-20hr  (6549) embryo 20-22hr  (4220) embryo 22-24hr  (4228) larva L1  (5400) larva L2  (9164) larva L3 12hr old  (17389) larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  (18306) adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  (17240) adult female 05day  (11428) adult female 30day  (12893) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2987) embryo 02-04hr  (3897) embryo 04-06hr  2274 embryo 06-08hr  2340 embryo 08-10hr  (3962) embryo 10-12hr  (5993) embryo 12-14hr  (3842) embryo 14-16hr  (6258) embryo 16-18hr  (6749) embryo 18-20hr  (6549) embryo 20-22hr  (4220) embryo 22-24hr  (4228) larva L1  (5400) larva L2  (9164) larva L3 12hr old  (17389) larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  (18306) adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  (17240) adult female 05day  (11428) adult female 30day  (12893) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old  17389 larva L3 puffstage 1-2  (27582) larva L3 puffstage 3-6  (23374) larva L3 puffstage 7-9  (26293) white prepupae new  (43065) white prepupae 12hr  (35288) white prepupae 24hr  (32629) pupae 2d postWPP  (31639) pupae 3d postWPP  (23020) pupae 4d postWPP  18306 adult male 01day  (33208) adult male 05day  (38111) adult male 30day  (31726) adult female 01day  17240 adult female 05day  11428 adult female 30day  12893 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2987 embryo 02-04hr    3897 embryo 04-06hr    2274 embryo 06-08hr    2340 embryo 08-10hr    3962 embryo 10-12hr    5993 embryo 12-14hr    3842 embryo 14-16hr    6258 embryo 16-18hr    6749 embryo 18-20hr    6549 embryo 20-22hr    4220 embryo 22-24hr    4228 larva L1    5400 larva L2    9164 larva L3 12hr old    17389 larva L3 puffstage 1-2    27582 larva L3 puffstage 3-6    23374 larva L3 puffstage 7-9    26293 white prepupae new    43065 white prepupae 12hr    35288 white prepupae 24hr    32629 pupae 2d postWPP    31639 pupae 3d postWPP    23020 pupae 4d postWPP    18306 adult male 01day    33208 adult male 05day    38111 adult male 30day    31726 adult female 01day    17240 adult female 05day    11428 adult female 30day    12893 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000261    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000261 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult spermathecae, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval/adult salivary gland, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000261 expression level Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules    4128 Larval Fat Body    3373.1 Larval Salivary Gland    338.1 Larval Trachea    1227.6 Larval Carcass    1663.6 Adult Head    1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    1354.9 Adult Midgut    1072 Adult Hindgut    827 Adult Malpighian Tubules    4821.9 Adult Fat Body    4304.4 Adult Salivary Gland    269.2 Adult Heart    4182.975 Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass    4177.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut  (977) Larval Hindgut    312.6 Larval Malpighian Tubules  (4128) Larval Fat Body  (3373.1) Larval Salivary Gland    338.1 Larval Trachea  (1227.6) Larval Carcass  (1663.6) Adult Head  (1020) Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop  (1354.9) Adult Midgut  (1072) Adult Hindgut  (827) Adult Malpighian Tubules  (4821.9) Adult Fat Body  (4304.4) Adult Salivary Gland    269.2 Adult Heart  (4182.975) Adult VirginFemale Spermatheca  (856) Adult InseminatedFemale Spermatheca  (628.8) Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass  (4177.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules  (4128) Larval Fat Body  (3373.1) Larval Salivary Gland    338.1 Larval Trachea  (1227.6) Larval Carcass  (1663.6) Adult Head  1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop  (1354.9) Adult Midgut  1072 Adult Hindgut    827 Adult Malpighian Tubules  (4821.9) Adult Fat Body  (4304.4) Adult Salivary Gland    269.2 Adult Heart  (4182.975) Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass  (4177.4) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules    4128 Larval Fat Body    3373.1 Larval Salivary Gland    338.1 Larval Trachea    1227.6 Larval Carcass    1663.6 Adult Head    1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    1354.9 Adult Midgut    1072 Adult Hindgut    827 Adult Malpighian Tubules    4821.9 Adult Fat Body    4304.4 Adult Salivary Gland    269.2 Adult Heart    4182.975 Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass    4177.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000261 expression level Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules    4128 Larval Fat Body    3373.1 Larval Salivary Gland    338.1 Larval Trachea    1227.6 Larval Carcass    1663.6 Adult Head    1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    1354.9 Adult Midgut    1072 Adult Hindgut    827 Adult Malpighian Tubules    4821.9 Adult Fat Body    4304.4 Adult Salivary Gland    269.2 Adult Heart    4182.975 Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass    4177.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut  (977) Larval Hindgut    312.6 Larval Malpighian Tubules  (4128) Larval Fat Body  (3373.1) Larval Salivary Gland    338.1 Larval Trachea  (1227.6) Larval Carcass  (1663.6) Adult Head  (1020) Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop  (1354.9) Adult Midgut  (1072) Adult Hindgut  (827) Adult Malpighian Tubules  (4821.9) Adult Fat Body  (4304.4) Adult Salivary Gland    269.2 Adult Heart  (4182.975) Adult VirginFemale Spermatheca  (856) Adult InseminatedFemale Spermatheca  628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass  (4177.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules  (4128) Larval Fat Body  (3373.1) Larval Salivary Gland    338.1 Larval Trachea  1227.6 Larval Carcass  1663.6 Adult Head  1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop  1354.9 Adult Midgut  1072 Adult Hindgut    827 Adult Malpighian Tubules  (4821.9) Adult Fat Body  (4304.4) Adult Salivary Gland    269.2 Adult Heart  (4182.975) Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass  (4177.4) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.275 Larval Midgut    977 Larval Hindgut    312.6 Larval Malpighian Tubules    4128 Larval Fat Body    3373.1 Larval Salivary Gland    338.1 Larval Trachea    1227.6 Larval Carcass    1663.6 Adult Head    1020 Adult Eye    334.225 Adult Brain    198.6 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    1354.9 Adult Midgut    1072 Adult Hindgut    827 Adult Malpighian Tubules    4821.9 Adult Fat Body    4304.4 Adult Salivary Gland    269.2 Adult Heart    4182.975 Adult VirginFemale Spermatheca    856 Adult InseminatedFemale Spermatheca    628.8 Adult Ovary    189.9 Adult Testis    455.8 Adult Male Accessory Gland    241.2 Adult Carcass    4177.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1020   NA  Eye    334.225   NA  Brain    198.6   240.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    217   NA  Crop    1354.9   977  Midgut    1072   312.6  Hindgut    827   4128  Malpighian Tubules    4821.9   3373.1  Fat Body    4304.4   338.1  Salivary Gland    269.2   NA  Heart    4182.975   1227.6  Trachea    NA   NA  VirginFemale Spermatheca    856   NA  InseminatedFemale Spermatheca    628.8   NA  Ovary    189.9   NA  Testis    455.8   NA  Male Accessory Gland    241.2   1663.6  Carcass    4177.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000261 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6871-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cat Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CatCC00907 lethal | recessive Catn1 Catn4 semi-lethal, with Scer\GAL4Act.PU CatScer\UAS.T:mito1 semi-lethal, with Scer\GAL4da.G32 CatScer\UAS.T:mito1 semi-lethal, with Scer\GAL4αTub84B.PL CatScer\UAS.T:mito1 viable Cate01301 CattOa viable, with Scer\GAL4pnr-MD237 CatGD1291 Sterility Allele fertile Cate01301 Other Phenotypes Allele chemical resistant CatAct5C.PS chemical sensitive Catn1 Catn2 Catn4 short lived Catn1 visible, with Scer\GAL4pnr-MD237 CatGD1291 wild-type Cat+t7 Phenotype manifest in Allele adult midgut Catn1 enterocyte Catn1 enteroendocrine cell | supernumerary Catn1 intestinal stem cell Catn1 trichogen cell, with Scer\GAL4pnr-MD237 CatGD1291
Classical Alleles ( 11 )
For All Classical Alleles Show
Allele of Cat Class Mutagen Stocks Known lesion Catn1 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes Cate01301 piggyBac transposase 2 -- Catn4 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Cat+hi hypermorphic allele - genetic evidence spontaneous 0 -- Cat+lo hypomorphic allele - genetic evidence spontaneous 0 -- CatCC00907 P-element activity 0 Yes CatCPTI002786 piggyBac transposase 0 Yes Catn2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Catn3 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Catn5 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Catn6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cat Class Mutagen Stocks Known lesion CatGD1291 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CatHMS00990 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CatJF02173 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CatKK101528 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CatScer\UAS.cAa in vitro construct - regulatory fusion 1 Yes Cat+t7 in vitro construct - genomic fragment 0 Yes CatA.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes CatAct5C.PS FLPase 0 Yes CatB.T:Ecol\lacZ in vitro construct - regulatory fusion 0 Yes CatC.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes CatD.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes CatScer\FRT.Act5C in vitro construct - regulatory fusion 0 Yes CatScer\UAS.T:mito1 in vitro construct - regulatory fusion 0 Yes CatT:mito1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes CattOa in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3L)W4 (Spradling et al., 1999) Df(3L)W10 (Spradling et al., 1999)
Disrupted in	Df(3L)Cat (Harshman et al., 1991, Wheeler et al., 1995, Orr et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Cat-lacZ.1756} No P{Cat-lacZ.A} No P{Cat-lacZ.B} No P{Cat-lacZ.C} No P{Cat-lacZ.D} No UAS construct P{GD1291} NA P{KK101528} NA P{TRiP.HMS00990} NA P{TRiP.JF02173} NA P{UAS-Cat.A} NA P{UAS-Cat.mt} NA characterization construct P{Act5C(FRT.polyA)Cat.S} NA P{Act5C(-FRT)Cat.S} NA P{Cat7.0} NA P{Cat+} NA P{OAT-Cat} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{hsneo}HipHop1 NA P{PTT-GC}CatCC00907 NA PBac{768.FSVS-0}CatCPTI002786 NA PBac{RB}Cate01301 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
catalase activity inferred from direct assay (Mackay and Bewley, 1989)
Biological Process
CV term Evidence References
response to hydrogen peroxide inferred from mutant phenotype (Sun and Tower, 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 11 terms )
Molecular Function
CV term Evidence References
antioxidant activity non-traceable author statement (Helfand and Rogina, 2003) catalase activity inferred from sequence or structural similarity with mouse Cat (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.8.1) heme binding inferred from electronic annotation with InterPro:IPR002226, InterPro:IPR011614, InterPro:IPR018028, InterPro:IPR020835, InterPro:IPR024711 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1990.8.1)
Biological Process
CV term Evidence References
aging traceable author statement (Luckinbill and Foley, 2000) calcium-dependent cell-cell adhesion non-traceable author statement (Swiss-Prot Project Members, 1990.8.1) determination of adult lifespan traceable author statement (Longo, 1999, Helfand and Rogina, 2003, Boulianne, 2001) oxidation-reduction process inferred from electronic annotation with InterPro:IPR011614, InterPro:IPR018028, InterPro:IPR020835, InterPro:IPR024711 (FlyBase Curators et al., 2004-) response to hydrogen peroxide traceable author statement (Aigaki et al., 2002) response to oxidative stress non-traceable author statement (Swiss-Prot Project Members, 1990.8.1)
Cellular Component
CV term Evidence References
peroxisome non-traceable author statement (Swiss-Prot Project Members, 1990.8.1) plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1990.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cat allele Gene References Catn1 Trxr-1 (Missirlis et al., 2001) CatScer\UAS.cMa Trxr-1 (Missirlis et al., 2001) unspecified Irc (Ha et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65329 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000261 DroID - A comprehensive database of gene and protein interactions. • FBgn0000261 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40048
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23641 Dere\GG13679 Dgri\GH14374 Dmoj\GI11318 Dpse\GA19920 Dsec\Cat Dsim\Cat Dvir\GJ11574 Dwil\GK12121 Dyak\GE19975
Curated drosophilid orthologs	Dpse\GA19920   Dsec\Cat   Dsim\Cat   Dsub\Cat
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013407-PA Aedes aegypti (mosquito) AGAP004904-PA Anopheles gambiae (mosquito) XP_001121393.1 Apis mellifera (honey bee) XP_001943641.1 Acyrthosiphon pisum (pea aphid) At1g20630.1 Arabidopsis thaliana (wall cress) 10953 Batrachochytrium dendrobatidis (chytrid fungus) 11164 Batrachochytrium dendrobatidis (chytrid fungus) 259757 Branchiostoma floridae (lancelet) BGIBMGA000701-PA Bombyx mori (silk worm) ENSBTAP00000027941 Bos taurus (bovine) CAL0000462 Candida albicans (a form of yeast) CN14680 Caenorhabditis brenneri (small nematode) CBP19937 Caenorhabditis briggsae (nematode) CE22476 Caenorhabditis elegans (worm) ENSCAFP00000010324 Canis familiaris (dog) CAGL0K10868g Candida glabrata (haploid yeast) ENSCINP00000010672 Ciona intestinalis (sea squirt) JA00699 Caenorhabditis japonica (nematode) CMI050C Cyanidioschyzon merolae (red alga) cn09081 Cryptococcus neoformans (yeast-like fungus) CPIJ007044 Culex pipens (mosquito) ENSCPOP00000011320 Cavia porcellus (guinea pig) 138310 Chlamidomonas reinhardtii (green alga) RP35251 Caenorhabditis remanei (nematode) ENSCSAVP00000002051 Ciona savignyi (sedentary tunicate) 163635 Capitella spl (polychaete worm) DDB0185123 Dictyostelium discoideum (amoeba) DEHA2F10582g Debaryomyces Hansenii (yeast) 308727 Daphnia pulex (daphnia) ENSECAP00000017490 Equus caballus (horse) YP_025308.1 Escherichia coli K12 (bacteria) ENSGACP00000004586 Gymnopilus aculeatus (mushroom) ENSGALP00000023319 Gallus gallus (chicken) 185390 Hypsipyla robusta (cedar shoot borer) ENSP00000241052 Homo sapiens (human) KLLA0D11660g Kluyveromyces lactis (yeast) 236064 Lottia gigantea (owl limpet) 15882 Monocosta brevicollis (choanoflagellate) ENSMODP00000012470 Monodelphis domestica (gray opossum) ENSMMUP00000003264 Macaca mulatta (rhesus monkey) ENSMUSP00000028610 Mus musculus (house mouse) XP_001601414.1 Nasonia vitripennis (wasp) ENSOANP00000011774 Ornithorynchus anatinus (platypus) ENSORLP00000002175 Oryzias latipes (japanese killifish) LOC_Os06g51150.1 Oryza sativa (asian rice) PHUM005668-PA Pediculus humanus (human body louse) PP21243 Pristionchus pacificus (nematode) 112228 Physcomitrella patens (moss) ENSPPYP00000003864 Pongo pygmaeus (orangutan) 71617 Phytophthora ramorum (sudden oak death pathogen) 129552 Phytophthora sojae (root rot pathogen) 831406 Populus trichocarpa (black cottonwood) ENSPTRP00000006074 Pan troglodytes (chimpanzee) ENSRNOP00000011230 Rattus norvegicus (norway rat) 147581 Sorghum bicolor (sorghum) YDR256C Saccharomyces cerevisiae (budding yeast) SPCC757.07c Schizosaccharomyces pombe (fission yeast) XP_786217.2 Strongylocentrotus purpuratus (purple sea urchin) 63434 Trichoplax adhaerens (metazoa) XP_970103.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008386 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041315 Takifugu rubripes (pufferfish Takifugu) 254.m00025 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008620 Xenopus tropicalis (frog) YALI0E34749g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16124 NV16124 LH22009 ISCW017124 FBgn0237302 FBgn0214132 FBgn0198832 FBgn0022505 FBgn0025059 JGI_V11_308727 FBgn0079916 FBgn0134079 FBgn0121850 FBgn0105943 FBgn0100635 CPIJ007044 BGIBMGA014511 BGIBMGA014510 BGIBMGA014284 BGIBMGA012691 BGIBMGA011430 BGIBMGA011431 BGIBMGA000701 ACYPI001032 GB30227 GB11648 CAT1 CAT1B PHUM336860 GLEAN_11385 GLEAN_11090 GLEAN_00084
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	24621 w1; P{UAS-Cat.A}2 17939 w1118; PBac{RB}Cate01301 31894 y1 v1; P{TRiP.JF02173}attP2 4014 Catn1/TM3, Sb1 Ser1 34020 y1 sc* v1; P{TRiP.HMS00990}attP2
Harvard	- PBac{RB}Cate01301
Kyoto	101586 Catn4 / TM3, Sb1 Ser1 107554 Catn1 / TM3, Sb1 Ser1
VDRC	v103591 P{KK101528}VIE-260B v6283 w1118; P{GD1291}v6283
Genomic Clones ( 1 )
	BACR48N04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 108 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE33242
Other clones	DPiM_RE33242
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01604 AT13275 AT13607 AT13683 AT14392 AT16241 AT18461 GH01138 GH05194 GH13701 GH14877 GH14972 GH15113 GH19618 GH22164 GH26088 GH27620 GM25605 HL02290 LD10455 LD13735 LD19383 LD32663 LD35713 LD37634 LD46457 LP03190 LP06450 LP07268 LP07634 LP10579 LP14451 LP18445 LP19533 LP20101 LP22539 RE04380 RE09632 RE30995 RE41316 RE57773 RE67415 RE70267 RE71087 RH20985 RH30274 RH35521 RH35632 RH36933 RH38727 RH42614 RH49972 RH54287 RH64435 RH66743 RH67828 RH68633 RH70542 RH72482 SD09024 SD10003 SD14579 SD17781 SD19235
Other clones	8871 31028 56905 57271 62828 62894 81140 117878 119989 149456 150003.1 161046 162957 524706 542583 bs35e11 bs36h11 CK01.31D.E2 CK01.60A.C3 Dmel_dig_010030_0625_1072 Dmel_neb_011081_0876_1955 EC28606 EC32291 EC37114 EC37184 EK042520 EK063310 EK170632 EK187842 EK237116 EK251562 EK265043 EK267126 EN05756 EN06805 EN10914 EN11704 ESG017a.E21_E01 ESG019c.E21_A07 ESG0112a.B21.1_E10 IP13670 SD26825
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000261 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40048
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and ClkJrk background. (Claridge-Chang et al., 2001) Overexpression of Cat significantly increases resistance to hydrogen peroxide but has neutral or slightly deleterious effects on adult life span. (Sun and Tower, 1999) 7kb Cat genomic fragment can provide functional rescue of the Cat mutant phenotype. Sequence elements that might be critical for the regulation of gene expression are identified by sequencing. (Orr et al., 1996) mRNA levels increase at adult day 5 in strain showing extended longevity phenotype (ELP). (Dudas and Arking, 1995) Some relationship exists between life span and antioxidant enzymes, the underlying mechanism of aging is not yet understood. Higher Cat activity is associated with reduced life span for e mutant. (Durusoy et al., 1995) Mutations in Cat or Sod can accelerate the induction of Hsp70 genes during aging. (Wheeler et al., 1995) Transgenic flies carrying three copies of Sod+ and three copies of Cat+ exhibited as much as one third extension of life span, a longer mortality rate doubling time, a lower amount of protein oxidative damage and a delayed loss in physical performance. Results support the free radical hypothesis of aging. (Orr and Sohal, 1994) Viability of acatalasemic flies can be restored by transformation with the wild type catalase gene. Though lack of catalase activity causes decreased viability and life span, increasing catalase activity above wild type levels had no effect on normal life span. (Griswold et al., 1993) Identification: Identified in 2D gels of CMW W2 wing imaginal disc cell proteins. (Santaren et al., 1993) Overexpression of Cat demonstrates enhanced levels of Cat does not prolong the life span, nor does it provide improved protection against oxidative stress induced by hyperoxia or paraquat treatment. It can provide enhanced resistance to hydrogen peroxide. (Orr and Sohal, 1992) D.melanogaster sensitivity to the deleterious effects of hydrogen peroxide increases when catalase activity is relatively low. (Harshman et al., 1991) The structural gene for catalase, a tetrameric enzyme. Two peaks of activity, the smaller in late third instar larvae just prior to puparium formation and the larger during metamorphosis; coincident with the two major peaks of ecdysone titer. High specific activity in larval Malpighian tubules, gut and fat body; higher in adult abdomen than in thorax or head. Amorphic and hypomorphic mutants are hemizygous viable on normal medium; however those with the lowest levels of catalase activity exhibit severely reduced viability (i.e., less than 2% normal levels). All mutants show increased sensitivity to the presence of hydrogen peroxide in the medium. No electromorphs detected among 50 inbred laboratory strains. (Nahmias and Bewley, 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080483 RefSeq (Proteins) • NP_536731 DDBJ / EMBL / GenBank • AAC13738 AAF49228 AAF49228.1 AAL89892 AF067922 AF067923 AI388653 AI947142 AI947262 AY084154 BI237084 CAA36529 CZ479106 U00145 X52286 X74367 Entrez Gene - A searchable database of RefSeq genes. • 40048 UniProtKB/Swiss-Prot • P17336
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Catalase-related immune responsive (IPR010582) Catalase, mono-functional, haem-containing (IPR018028) Catalase haem-binding site (IPR002226) Catalase, N-terminal (IPR011614) Catalase domain (IPR020835) Catalase active site (IPR024708) Catalase, mono-functional, haem-containing, clades 1 and 3 (IPR024711)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65329 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000261 DroID - A comprehensive database of gene and protein interactions. • FBgn0000261 DRSC - Results from RNAi screens. • FBgn0000261 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000261 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6871-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000261 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40048 InParanoid A subset of ortholog calls from InParanoid. • AAEL013407-PA Aedes aegypti (mosquito) AGAP004904-PA Anopheles gambiae (mosquito) XP_001121393.1 Apis mellifera (honey bee) XP_001943641.1 Acyrthosiphon pisum (pea aphid) At1g20630.1 Arabidopsis thaliana (wall cress) 10953 Batrachochytrium dendrobatidis (chytrid fungus) 11164 Batrachochytrium dendrobatidis (chytrid fungus) 259757 Branchiostoma floridae (lancelet) BGIBMGA000701-PA Bombyx mori (silk worm) ENSBTAP00000027941 Bos taurus (bovine) CAL0000462 Candida albicans (a form of yeast) CN14680 Caenorhabditis brenneri (small nematode) CBP19937 Caenorhabditis briggsae (nematode) CE22476 Caenorhabditis elegans (worm) ENSCAFP00000010324 Canis familiaris (dog) CAGL0K10868g Candida glabrata (haploid yeast) ENSCINP00000010672 Ciona intestinalis (sea squirt) JA00699 Caenorhabditis japonica (nematode) CMI050C Cyanidioschyzon merolae (red alga) cn09081 Cryptococcus neoformans (yeast-like fungus) CPIJ007044 Culex pipens (mosquito) ENSCPOP00000011320 Cavia porcellus (guinea pig) 138310 Chlamidomonas reinhardtii (green alga) RP35251 Caenorhabditis remanei (nematode) ENSCSAVP00000002051 Ciona savignyi (sedentary tunicate) 163635 Capitella spl (polychaete worm) DDB0185123 Dictyostelium discoideum (amoeba) DEHA2F10582g Debaryomyces Hansenii (yeast) 308727 Daphnia pulex (daphnia) ENSECAP00000017490 Equus caballus (horse) YP_025308.1 Escherichia coli K12 (bacteria) ENSGACP00000004586 Gymnopilus aculeatus (mushroom) ENSGALP00000023319 Gallus gallus (chicken) 185390 Hypsipyla robusta (cedar shoot borer) ENSP00000241052 Homo sapiens (human) KLLA0D11660g Kluyveromyces lactis (yeast) 236064 Lottia gigantea (owl limpet) 15882 Monocosta brevicollis (choanoflagellate) ENSMODP00000012470 Monodelphis domestica (gray opossum) ENSMMUP00000003264 Macaca mulatta (rhesus monkey) ENSMUSP00000028610 Mus musculus (house mouse) XP_001601414.1 Nasonia vitripennis (wasp) ENSOANP00000011774 Ornithorynchus anatinus (platypus) ENSORLP00000002175 Oryzias latipes (japanese killifish) LOC_Os06g51150.1 Oryza sativa (asian rice) PHUM005668-PA Pediculus humanus (human body louse) PP21243 Pristionchus pacificus (nematode) 112228 Physcomitrella patens (moss) ENSPPYP00000003864 Pongo pygmaeus (orangutan) 71617 Phytophthora ramorum (sudden oak death pathogen) 129552 Phytophthora sojae (root rot pathogen) 831406 Populus trichocarpa (black cottonwood) ENSPTRP00000006074 Pan troglodytes (chimpanzee) ENSRNOP00000011230 Rattus norvegicus (norway rat) 147581 Sorghum bicolor (sorghum) YDR256C Saccharomyces cerevisiae (budding yeast) SPCC757.07c Schizosaccharomyces pombe (fission yeast) XP_786217.2 Strongylocentrotus purpuratus (purple sea urchin) 63434 Trichoplax adhaerens (metazoa) XP_970103.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008386 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000041315 Takifugu rubripes (pufferfish Takifugu) 254.m00025 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000008620 Xenopus tropicalis (frog) YALI0E34749g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40048 modMine - Data generated by the modENCODE project. • FBgn0000261 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16124 NV16124 LH22009 ISCW017124 FBgn0237302 FBgn0214132 FBgn0198832 FBgn0022505 FBgn0025059 JGI_V11_308727 FBgn0079916 FBgn0134079 FBgn0121850 FBgn0105943 FBgn0100635 CPIJ007044 BGIBMGA014511 BGIBMGA014510 BGIBMGA014284 BGIBMGA012691 BGIBMGA011430 BGIBMGA011431 BGIBMGA000701 ACYPI001032 GB30227 GB11648 CAT1 CAT1B PHUM336860 GLEAN_11385 GLEAN_11090 GLEAN_00084 REDfly - A database of transcriptional regulatory elements. • FBgn0000261
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	bs36h11.y1 (Andrews et al., 2000) cat (Luckinbill and Foley, 2000, Wicks et al., 2009, Gao et al., 2010, Krishnan et al., 2008, Tsuda et al., 2010, Wang et al., 2008, Boyd et al., 2011, Riedl et al., 2005) CAT (Arking, 1998, Arking et al., 1996, Gaivao and Comendador, 1996, Choudhary et al., 1992, Kawata et al., 1991, Roesijadi et al., 2007, Rival et al., 2009, Xu et al., 2008, Vontas et al., 2001, Gupta et al., 2005) Cat (Geiger-Thornsberry and Mackay, 2004, Park et al., 2004, Gruenewald et al., 2009, Anderson et al., 2005, Buszczak et al., 2007, Hueber et al., 2007, Dorus et al., 2006, Anderson et al., 2008, Morey et al., 2003, Bosveld et al., 2008, Dierick and Greenspan, 2006, Choi et al., 2008, Radyuk et al., 2010, Wasbrough et al., 2010) CATA (Mushegian et al., 1998) CatA (Klotz et al., 1997) CG6871 (Pile et al., 2003, Keleman et al., 2009.8.5, Perkins et al., 2009, Terhzaz et al., 2010, Ni et al., 2010.12.1, Riedl et al., 2005, Cammarato et al., 2011) CT21282 (Xie and Ding, 2000) DMCATHPO (Fernando Vazquez et al., 2000, Lopez et al., 1999, Colson and Goldstein, 1999, Schug et al., 1997) DROCATHPO (Schug et al., 1998) U00145 (Ptak and Petrov, 2002)
Name Synonym	catalase (Mandavilli et al., 2002, Helfand and Rogina, 2003, Orr et al., 2000, Orr, 1993.8.3, Mahafey, 1993.10.7, Colson, 1998.5.26, Colson, 1998.5.26, Carlson and Derr, 2007, Park et al., 2004, Morey et al., 2003, Lee et al., 2010, Bayne et al., 2005, Bosveld et al., 2008, Xu et al., 2008, Choi et al., 2008, Soh et al., 2007, Mockett et al., 1999, Krishnan et al., 2008, Rival et al., 2009, Tsuda et al., 2010, Park et al., 2010, Gupta et al., 2005, Wang et al., 2008, Boyd et al., 2011, Tuxworth et al., 2011, Vrailas-Mortimer et al., 2011) Catalase (Southall et al., 2006, Geiger-Thornsberry and Mackay, 2004, Gutierrez et al., 2007, Lai et al., 2007, List et al., 2009, Gao et al., 2010, Barnes et al., 2010, Terhzaz et al., 2010, Besson et al., 2010, Cammarato et al., 2011) CATHPO (Colson and Goldstein, 1999) cytosolic catalase (Longo, 1999)
Secondary FlyBase IDs
	FBgn0011460 FBgn0026841
References ( 156 )
Generate a list of	All references relating to this gene ( 156 )
List References by type	Research paper  ( 93 ) Supplementary material  ( 7 ) Review  ( 21 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 13 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 11 )
	Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Vrailas-Mortimer et al., 2011, Dev. Cell 21(4): 783--795 A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila. [FBrf0216446] Barnes et al., 2010, BMC Biochem. 11: 26 Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function. [FBrf0211360] Besson et al., 2010, Hum. Mol. Genet. 19(17): 3372--3382 Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease. [FBrf0211472] Gao et al., 2010, EMBO J. 29(4): 819--829 HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. [FBrf0210059] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Park et al., 2010, Biochim. biophys. Acta 1799(7): 510--519 Regulation of the Drosophila p38b gene by transcription factor DREF in the adult midgut. [FBrf0211129] Radyuk et al., 2010, Free Radical Biol. Med. 49(12): 1892--1902 Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila. [FBrf0212530] Terhzaz et al., 2010, Cell. Signal. 22(5): 737--748 Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. [FBrf0210037] Tsuda et al., 2010, FEBS Lett. 584(15): 3398--3401 Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. [FBrf0211377] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...