FB2020_01, released Feb 12, 2020

Gene: Dmel\Pka-C2

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General Information
Symbol
Dmel\Pka-C2
Species
D. melanogaster
Name
Protein kinase, cAMP-dependent, catalytic subunit 2
Annotation Symbol
CG12066
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000274
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
cAMP-dependent protein kinase (2.7.11.11)
Gene Snapshot
Insufficient genetic data for FlyBase to solicit a summary. [Date last reviewed: 2016-06-30]
Other Summaries
Also Known As

PKA, DC1, PKA C2

Key Links
Genomic Location
Cytogenetic map
100A2-100A2
Sequence location
3R:30,695,537..30,697,138 [-]
Recombination map

3-101

RefSeq locus
NT_033777 REGION:30695537..30697138
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (P16911)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding; protein serine/threonine kinase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.11)
Summaries
Gene Group (FlyBase)
PROTEIN KINASE A FAMILY -
The Protein Kinase A (PKA) or cAMP-dependent protein kinases are serine/threonine kinases activated by cAMP. The PKA catalytic subunit is maintained in an inactive state in a heterotetrameric complex consisting of two catalytic (C) subunits bound to two regulatory (R) subunits. Binding of cAMP to the R subunits, releases the C subunits from inhibition. (Adapted from PMID:20027184).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Pka-C2 or the JBrowse view of Dmel\Pka-C2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pka-C2-RB
FBtr0085727
NM_170518
1349
354
Pka-C2-RC
FBtr0335454
NM_079856
1346
353
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pka-C2-PB
FBpp0085089
41.5
354
8.71
NP_733397
AAN14254
Pka-C2-PC
FBpp0307432
41.4
353
8.71
NP_524595
AAF57077
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

376, 354 (aa)

(Kalderon and Rubin, 1988)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pka-C2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (8 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
cAMP-dependent protein kinase activity
inferred from sequence or structural similarity with UniProtKB:P17612
(FlyBase Curators, 2008--)
protein kinase A regulatory subunit binding
inferred from sequence or structural similarity with UniProtKB:P17612
(FlyBase Curators, 2008--)
protein serine/threonine kinase activity
inferred from sequence or structural similarity with UniProtKB:P17612
(FlyBase Curators, 2008--)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
peptidyl-serine phosphorylation
inferred from sequence or structural similarity with UniProtKB:P17612
(FlyBase Curators, 2008--)
protein kinase A signaling
inferred from biological aspect of ancestor with PANTHER:PTN000682577
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleotide-activated protein kinase complex
inferred from sequence or structural similarity with UniProtKB:P17612
(FlyBase Curators, 2008--)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000682577
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage & adult stage
(Kalderon and Rubin, 1988)
Additional Descriptive Data

Pka-C2 transcripts are detected in pupae and adults and are more abundant in adult bodies than heads. A slightly smaller transcript is detected in embryos.

(Kalderon and Rubin, 1988)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pka-C2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pka-C2
Transgenic constructs containing regulatory region of Pka-C2
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PRKACA
6 of 15
Yes
No
Hsap\PRKACG
6 of 15
Yes
No
Hsap\PRKACB
5 of 15
No
No
Hsap\PRKX
3 of 15
No
No
Hsap\PRKG1
1 of 15
No
No
 
Hsap\PRKG2
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Prkaca
6 of 15
Yes
No
Mmus\Prkacb
4 of 15
No
No
Mmus\Prkx
3 of 15
No
No
Mmus\Prkg1
1 of 15
No
No
Mmus\Prkg2
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Prkaca
5 of 13
Yes
No
Rnor\Prkacb
4 of 13
No
No
Rnor\Prkx
2 of 13
No
No
Rnor\LOC685303
1 of 13
No
Yes
Rnor\Prkg2
1 of 13
No
No
 
Xenopus tropicalis (Western clawed frog) (20)
Xtro\prkaca
3 of 12
Yes
No
Xtro\prkacb
3 of 12
Yes
No
Xtro\prkx
2 of 12
No
No
Xtro\LOC100485620
1 of 12
No
Yes
Xtro\LOC100488597
1 of 12
No
Yes
Xtro\LOC100488761
1 of 12
No
Yes
Xtro\LOC100492960
1 of 12
No
Yes
Xtro\LOC100498287
1 of 12
No
Yes
Xtro\LOC101731335
1 of 12
No
Yes
Xtro\LOC101731405
1 of 12
No
Yes
Xtro\LOC101731454
1 of 12
No
Yes
Xtro\LOC101732362
1 of 12
No
Yes
Xtro\LOC101732819
1 of 12
No
Yes
Xtro\LOC101734217
1 of 12
No
Yes
Xtro\LOC105947584
1 of 12
No
Yes
Xtro\LOC105948370
1 of 12
No
Yes
Xtro\LOC108648806
1 of 12
No
Yes
Xtro\LOC108648813
1 of 12
No
Yes
Xtro\LOC108648814
1 of 12
No
Yes
Xtro\prkg2
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\prkacaa
5 of 15
Yes
No
Drer\prkacab
5 of 15
Yes
No
Drer\prkacba
5 of 15
Yes
No
Drer\prkacbb
5 of 15
Yes
No
Drer\prkx
3 of 15
No
No
Drer\LOC556339
1 of 15
No
No
Drer\LOC101883269
1 of 15
No
Yes
Drer\LOC108179012
1 of 15
No
No
Drer\prkg1b
1 of 15
No
No
Drer\prkg2
1 of 15
No
No
Drer\si:dkey-121j17.5
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\kin-1
5 of 15
Yes
No
Cele\F47F2.1
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (3)
Atha\AT2G20050
1 of 9
Yes
No
Atha\AT2G20470
1 of 9
Yes
No
Atha\AT3G23310
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\TPK2
7 of 15
Yes
No
Scer\TPK1
6 of 15
No
No
Scer\TPK3
6 of 15
No
No
Scer\YPK3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\pka1
2 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909YR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Pka-C2
Drosophila simulans
Dsim\GD16880
Drosophila sechellia
Dsec\GM12137
Drosophila erecta
Dere\GG11916
Drosophila yakuba
Dyak\GE23365
Drosophila ananassae
Dana\GF23314
Drosophila pseudoobscura pseudoobscura
Dpse\GA11370
Drosophila persimilis
Dper\GL13992
Drosophila willistoni
Dwil\GK13113
Drosophila virilis
Dvir\GJ22991
Drosophila mojavensis
Dmoj\GI10635
Drosophila grimshawi
Dgri\GH14103
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506EB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007920
Musca domestica
House fly
Mdoa\17017366
Musca domestica
House fly
Mdoa\17007919
Musca domestica
House fly
Mdoa\17021128
Musca domestica
House fly
Mdoa\17019618
Glossina morsitans
Tsetse fly
Gmor\GMOY008941
Glossina morsitans
Tsetse fly
Gmor\GMOY006407
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13883
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00566
Mayetiola destructor
Hessian fly
Mdes\Mdes013798
Mayetiola destructor
Hessian fly
Mdes\Mdes006866
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001976
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014878
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007293
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011837
Anopheles darlingi
American malaria mosquito
Adar\ADAC002688
Anopheles darlingi
American malaria mosquito
Adar\ADAC003465
Anopheles darlingi
American malaria mosquito
Adar\ADAC000002
Anopheles gambiae
Malaria mosquito
Agam\AGAP001384
Anopheles gambiae
Malaria mosquito
Agam\AGAP008039
Anopheles gambiae
Malaria mosquito
Agam\AGAP011840
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000798
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002636
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018257
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06IH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001163
Bombyx mori
Silkmoth
Bmor\BGIBMGA005952
Bombyx mori
Silkmoth
Bmor\BGIBMGA000982
Bombyx mori
Silkmoth
Bmor\BGIBMGA011429
Danaus plexippus
Monarch butterfly
Dple\DPOGS207641-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213835-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211896-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS214228-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL014091
Heliconius melpomene
Postman butterfly
Hmel\HMEL012838
Apis florea
Little honeybee
Aflo\2715886020
Apis florea
Little honeybee
Aflo\2406634356
Apis florea
Little honeybee
Aflo\2796615540
Apis mellifera
Western honey bee
Amel\GB51562
Apis mellifera
Western honey bee
Amel\Pka-C3
Apis mellifera
Western honey bee
Amel\Pka-C1
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10635
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20247
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16881
Bombus terrestris
Buff-tailed bumblebee
Bter\15202864
Bombus terrestris
Buff-tailed bumblebee
Bter\15213542
Linepithema humile
Argentine ant
Lhum\LH22324
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024ad
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011355
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014242
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06309
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02762
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00512
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08675
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00619
Tribolium castaneum
Red flour beetle
Tcas\TC011406
Tribolium castaneum
Red flour beetle
Tcas\Pka-C1
Tribolium castaneum
Red flour beetle
Tcas\TC014143
Pediculus humanus
Human body louse
Phum\PHUM318270
Pediculus humanus
Human body louse
Phum\PHUM318060
Pediculus humanus
Human body louse
Phum\PHUM137480
Pediculus humanus
Human body louse
Phum\PHUM090820
Rhodnius prolixus
Kissing bug
Rpro\RPRC007991
Rhodnius prolixus
Kissing bug
Rpro\RPRC012556
Rhodnius prolixus
Kissing bug
Rpro\RPRC009810
Rhodnius prolixus
Kissing bug
Rpro\RPRC013140
Cimex lectularius
Bed bug
Clec\CLEC005636
Cimex lectularius
Bed bug
Clec\CLEC006486
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000519
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16009
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00230
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X06E7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015707
Strigamia maritima
European centipede
Smar\SMAR011074
Ixodes scapularis
Black-legged tick
Isca\ISCW013988
Ixodes scapularis
Black-legged tick
Isca\ISCW002700
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71276.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60498.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65718.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g02970
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51329
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_229422
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319998
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G10O8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pka
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pkx1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-PkaC
Ciona intestinalis
Vase tunicate
Cint\LOC100175976
Ciona intestinalis
Vase tunicate
Cint\LOC100176009
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028530
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026389
Gallus gallus
Domestic chicken
Ggal\PRKX
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG12069
6 of 10
Pka-C1
6 of 10
Pka-C3
4 of 10
CG4839
3 of 10
for
3 of 10
Pkg21D
3 of 10
S6KL
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Pka-C2KK110127
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.1-208.UAS
    (Gonzales et al., 2016)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PRKACA; protein kinase cAMP-activated catalytic subunit alpha
    6 of 15
    601639
    PRKACG; protein kinase cAMP-activated catalytic subunit gamma
    6 of 15
    176893
    PRKACB; protein kinase cAMP-activated catalytic subunit beta
    5 of 15
    176892
        PRKX; protein kinase X-linked
        3 of 15
        300083
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-101

            Cytogenetic map
            100A2-100A2
            Sequence location
            3R:30,695,537..30,697,138 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            100A2-100A2
            Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            100A-100A
            (determined by in situ hybridisation)
            (Kalderon and Rubin, 1988)
            Experimentally Determined Recombination Data
            Location

            3-101

            (FlyBase, 2016)

            3-98.7

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (7)
            Genomic Clones (13)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (8)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of
              Additional comments
              Other Comments

              When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, spindle abnormalities and chromosome abnormalities are seen.

              (Bettencourt-Dias et al., 2004)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              Isolated from a genomic library using a Pka-C1 probe.

              (Kalderon and Rubin, 1988)

              Pka-C2 may encode a protein kinase.

              (Kalderon and Rubin, 1988)

              One of 11 cAMP-dependent D.melanogaster DNA clones whose sequences are similar to that of Pka-C1 within the kinase domain identified by nucleic acid hybridization. Pka-C2 shows 45% amino acid identity to the corresponding mouse protein kinase

              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 40 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Synonyms and Secondary IDs (12)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
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              References (59)