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Gene Dmel\CecA2

General Information
Symbol	Dmel\CecA2	Species	D. melanogaster
Name	Cecropin A2	Annotation symbol	CG1367
Feature type	protein_coding_gene	FlyBase ID	FBgn0000277
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	CecA, Cec, crpA2
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99E2-99E2	Sequence location	3R:26,037,878..26,038,291 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cecropin A2 is referred to in FlyBase by the symbol Dmel\CecA2 (CG1367, FBgn0000277). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium; humoral immune response; defense response to Gram-positive bacterium; antibacterial humoral response. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of CecA2. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of CecA2. Gene sequence location is 3R:26037878..26038291.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cec: Cecropin Three structural genes for three very similar cecropin proteins (cecropin A1, A2, and B), bacteriacidal proteins that are induced in adults in response to bacterial infection. All three cecropin genes are coordinately induced by injection of bacteria, although the B gene is expressed at a much lower level. Levels appreciable within one hour, peak at 6 hours and have generally returned to base line by 24 hours. Cecropins also induced by ingested bacteria.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Abdelsadik and Roeder, 2010, BMC Genomics 11: 265
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99E2-99E2   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CecA2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CecA2-RA FBtr0085614  NM_079850   356   63
Additional Transcript Data & Comments
Reported size (kB)	0.4 (northern blot) (Kylsten et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CecA2-PA   FBpp0084978   6.8   63   10.84     NP_524589   AAF57026
Additional Polypeptide Data & Comments
Reported size (kDa)	63 (kD) (Kylsten et al., 1990)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57026   AB010791 BAA28721   AB010792 BAA28725   AB010793 BAA28728   AB010794 BAA28732   AB010795 BAA28734   AB010796 BAA28738   AB010797 BAA28742   AF018976 AAB82473   AF018977 AAB82474   AF018978 AAB82475   AF018979 AAB82476   AF018980 AAB82477   AF018981 AAB82478   AF018982 AAB82479   AF018983 AAB82480   AF018984 AAB82481   BT032790   BT032796   CO154445   CO154746   CO155427   CO155641   CO155755   CO156221   CO156586   CO335319   CO335997   CO336103   CO336149   CO336476   CO336871   CO336995   CO337366   CO337378   CO337929   CO338778   EC261320   EC261764   EC262292   EC262822   EC263226   EC264195   EC264241   EC265131   EC265965   EC266565   EC266593   EC266605   EC266993   EC267420   EC267597   EC267913   EC267972   X16972 CAA34844   Y16852 CAA76427   Y16853 CAA76433   Y16854 CAA76439   Y16855 CAA76445   Y16856 CAA76451   Y16857 CAA76457   Y16858 CAA76463   Y16859 CAA76469   Y16861 CAA76479
UniProtKB/Swiss-Prot	P14954
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   adult fat body   (Samakovlis et al., 1990) in situ Stage Tissue/Position (including subcellular localization) Reference larval stage   embryonic/larval hemocyte   (Samakovlis et al., 1990) pupal stage     (Samakovlis et al., 1990)
Additional Descriptive Data
	CecA2 transcripts are only detected in untreated animals in small amounts in early pupae and adults. The transcripts are strongly induced by bacteria. CecA expression is stronger in fat body than CecB but they are at comparable levels in hemocytes. (Samakovlis et al., 1990) Cecropin mRNAs are induced after injection of a bacterial suspension into adult abdomens. They can also be induced by feeding flies bacteria-containing food. (Kylsten et al., 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000277    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000277 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected. Peak expression observed during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000277 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old  (127) larva L3 puffstage 1-2  (229) larva L3 puffstage 3-6  (417) larva L3 puffstage 7-9  (273) white prepupae new  (783) white prepupae 12hr  (5434) white prepupae 24hr  (740) pupae 2d postWPP  (509) pupae 3d postWPP  (127) pupae 4d postWPP    47 adult male 01day  (690) adult male 05day  (698) adult male 30day  (1538) adult female 01day  (1480) adult female 05day  (664) adult female 30day  (5076) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr  (5434) white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day  (1538) adult female 01day  1480 adult female 05day    664 adult female 30day  (5076) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000277 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old  127 larva L3 puffstage 1-2  (229) larva L3 puffstage 3-6  (417) larva L3 puffstage 7-9  (273) white prepupae new  (783) white prepupae 12hr  (5434) white prepupae 24hr  (740) pupae 2d postWPP  (509) pupae 3d postWPP  127 pupae 4d postWPP    47 adult male 01day  (690) adult male 05day  (698) adult male 30day  (1538) adult female 01day  (1480) adult female 05day  (664) adult female 30day  (5076) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr  (5434) white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day  1538 adult female 01day  1480 adult female 05day    664 adult female 30day  (5076) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    2 embryo 06-08hr    0 embryo 08-10hr    3 embryo 10-12hr    5 embryo 12-14hr    9 embryo 14-16hr    3 embryo 16-18hr    5 embryo 18-20hr    3 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    10 larva L2    0 larva L3 12hr old    127 larva L3 puffstage 1-2    229 larva L3 puffstage 3-6    417 larva L3 puffstage 7-9    273 white prepupae new    783 white prepupae 12hr    5434 white prepupae 24hr    740 pupae 2d postWPP    509 pupae 3d postWPP    127 pupae 4d postWPP    47 adult male 01day    690 adult male 05day    698 adult male 30day    1538 adult female 01day    1480 adult female 05day    664 adult female 30day    5076 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000277
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CecA2GD3966 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CecA2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CecA2 Class Mutagen Stocks Known lesion CecA2GD3966 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)R113 (Clark and Wang, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3966} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from expression pattern AND inferred from sequence or structural similarity (Kylsten et al., 1990) defense response to Gram-negative bacterium inferred from direct assay (Samakovlis et al., 1990) defense response to Gram-positive bacterium inferred from direct assay (Samakovlis et al., 1990) humoral immune response inferred from expression pattern (Verleyen et al., 2006)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Verleyen et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) defense response to bacterium non-traceable author statement (Lemaitre, 2000.12.20) defense response to fungus non-traceable author statement (Lemaitre, 2000.12.20) defense response to Gram-negative bacterium non-traceable author statement (Swiss-Prot Project Members, 1990.4.1) defense response to Gram-positive bacterium non-traceable author statement (Swiss-Prot Project Members, 1990.4.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CecA2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000277 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43597
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmau\CecA2   Dpse\CecIII   Dvir\Cec1   Dvir\Cec2A   Dvir\Cec2B   Dvir\Cec3   Dyak\CecA2 (Date, 1998.1.27)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228702 FBgn0025039 FBgn0025653 FBgn0000276
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v9715 w1118; P{GD3966}v9715 v9714 w1118; P{GD3966}v9714/CyO
Genomic Clones ( 1 )
	BACR05L15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	IP21250 IP21350
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	522011 523706 524077 524843 525080 525547 527864 533998 556883 557004 557054 557892 561927 562054 569020 569033 569782 EN04138 EN04721 EN06029 EN06457 EN06664 EN08343 EN10017 EN11624 EN11837 EN11936 EN12617 EN13410 EN13626 EN14357 EN14413 EN15615 EN17601
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000277 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43597
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CecA2 CG1367 (Ye, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) Genes encoding antibacterial peptides are regulated in a manner distinct from that of Drs, encoding the antifungal peptide. The Cecropins require the spz-cact regulatory cassette for expression at the adult stage. (Lemaitre et al., 1996) Transcription is not strongly induced by hymenopteran parasitoids. (Nicolas et al., 1996) One of four structural genes for four very similar cecropin proteins (cecropin A1, A2, B and C), bacteriocidal proteins that are induced in adults in response to bacterial infection. All cecropin genes are coordinately induced by injection of bacteria, although the B gene is expressed at a much lower level. Cecropins also induced by ingested bacteria. (Lindsley and Zimm, 1992) CecA2 and CecC show a moderate transcriptional response to bacterial lipopolysaccharide and bacterial flagellin in Schneider cells, but no response in Kc cells. (Samakovlis et al., 1992) The Cec gene region contains three genes: CecA1, CecA2 and CecB. Cecropins are antibacterial peptides: transcripts appear within one hour after bacteria has been injected in to the haemocoel. (Kylsten et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079850 RefSeq (Proteins) • NP_524589 DDBJ / EMBL / GenBank • AAB82473 AAB82474 AAB82475 AAB82476 AAB82477 AAB82478 AAB82479 AAB82480 AAB82481 AAF57026 AAF57026.1 AB010791 AB010792 AB010793 AB010794 AB010795 AB010796 AB010797 AF018976 AF018977 AF018978 AF018979 AF018980 AF018981 AF018982 AF018983 AF018984 BAA28721 BAA28725 BAA28728 BAA28732 BAA28734 BAA28738 BAA28742 CAA34844 CAA76427 CAA76433 CAA76439 CAA76445 CAA76451 CAA76457 CAA76463 CAA76469 CAA76479 X16972 Y16852 Y16853 Y16854 Y16855 Y16856 Y16857 Y16858 Y16859 Y16861 Entrez Gene - A searchable database of RefSeq genes. • 43597 UniProtKB/Swiss-Prot • P14954
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000277 DRSC - Results from RNAi screens. • FBgn0000277 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000277 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000277 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43597 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43597 modMine - Data generated by the modENCODE project. • FBgn0000277 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0228702 FBgn0025039 FBgn0025653 FBgn0000276
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	Cec (Gottar et al., 2002, Engstrom et al., 2001, Ryu et al., 2008, Ren et al., 2007) cec (Comeron and Kreitman, 2000, Gesellchen et al., 2005, Abdelsadik and Roeder, 2010) CecA (Hedengren-Olcott et al., 2004, Rabel et al., 2004, Werner et al., 2003, Ekengren and Hultmark, 2001, Lu et al., 2001, Dushay et al., 2000, Lemaitre et al., 1996) cecA (Leulier et al., 2000, Fedorka et al., 2007) CecA2 (Waterhouse et al., 2007, Sackton and Clark, 2009, Shin, 2005, Kim et al., 2007, McGraw et al., 2008, Kapelnikov et al., 2008, Sackton et al., 2007, Spresser et al., 2008, Heger and Ponting, 2007) cecA2 (McDonald and Rosbash, 2001, Lemaitre, 2000.12.20, Gesellchen et al., 2005, Zsindely et al., 2009) Cec A2 (Douglas et al., 2011) CG1367 (Irving et al., 2001, De Gregorio et al., 2001, Pal et al., 2007, Verleyen et al., 2006, Hernandez-Romano et al., 2008, Heger and Ponting, 2007, Douglas et al., 2011) crpA2 (Winterhalter and Fedorka, 2009, Marshall and Sinclair, 2010) unnamed (Kylsten, 1990.11.20)
Name Synonym	Cecropin (Steiner, 2004, Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Pletcher et al., 2002, Wiklund et al., 2002, Kimbrell and Beutler, 2001, Rutschmann et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Govind, 1999, Han et al., 1998, Mathey-Prevot and Perrimon, 1998, Roos et al., 1997, Ryu et al., 2008, Ligoxygakis et al., 2002, Costa et al., 2009) cecropin (Leclerc and Reichhart, 2004, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Ando et al., 1999, Hoffmann et al., 1999, Meng et al., 1999, Hoffmann, 1997, Martin-Blanco, 1997, Zelinger and Heifetz, 2006, Persson et al., 2007, Marshall and Sinclair, 2010) cecropin A (Boulanger et al., 2002, Lowenberger et al., 1999, Uttenweiler-Joseph et al., 1998, Fedorka et al., 2007) Cecropin A (Hedengren-Olcott et al., 2002, Shin, 2005, Wu et al., 2007) Cecropin-A (Luo et al., 2001) Cecropin-A1/A2 precursor (Hernandez-Romano et al., 2008) cecropin A2 (Date, 1998.1.27, Date, 1998.1.27, Date, 1998.1.27, Date, 1998.1.27, Date, 1998.1.27, Date, 1998.1.27, Date, 1998.1.27, Douglas et al., 2011) Cecropin A2 (Pal et al., 2007, Kim et al., 2007, Buchon et al., 2009, Roxstrom-Lindquist et al., 2004, Verleyen et al., 2006, Wiklund et al., 2009) cecropinA2 (Gesellchen et al., 2005)
Secondary FlyBase IDs
References ( 128 )
Generate a list of	All references relating to this gene ( 128 )
List References by type	Research paper  ( 74 ) Supplementary material  ( 2 ) Review  ( 21 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 11 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 10 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Abdelsadik and Roeder, 2010, BMC Genomics 11: 265 Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes. [FBrf0214863] Marshall and Sinclair, 2010, Proc. Biol. Sci. 277(1683): 963--969 Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. [FBrf0209895] Willis et al., 2010, J. Insect Sci. 10: 66 Microarray Analysis of Juvenile Hormone Response in Drosophila melanogaster S2 cells. [FBrf0211402] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...