• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CecC

General Information
Symbol	Dmel\CecC	Species	D. melanogaster
Name	Cecropin C	Annotation symbol	CG1373
Feature type	protein_coding_gene	FlyBase ID	FBgn0000279
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	Cec, Cec-C
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99E2-99E2	Sequence location	3R:26,042,206..26,042,659 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cecropin C is referred to in FlyBase by the symbol Dmel\CecC (CG1373, FBgn0000279). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium; humoral immune response; defense response to Gram-positive bacterium; antibacterial humoral response. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cecropin, diptera. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1632719_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CecC. Gene sequence location is 3R:26042206..26042659.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cec: Cecropin Three structural genes for three very similar cecropin proteins (cecropin A1, A2, and B), bacteriacidal proteins that are induced in adults in response to bacterial infection. All three cecropin genes are coordinately induced by injection of bacteria, although the B gene is expressed at a much lower level. Levels appreciable within one hour, peak at 6 hours and have generally returned to base line by 24 hours. Cecropins also induced by ingested bacteria.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Date-Ito et al., 2002, J. molec. Evol. 54(5): 665--670
FB2012_01	References Abdelsadik and Roeder, 2010, BMC Genomics 11: 265 Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Sequence features BKN42362 HFA16606
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99E2-99E2   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CecC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CecC-RA FBtr0085616  NM_079852   385   63
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CecC-PA   FBpp0084980   6.8   63   11.21     NP_524591   AAF57028
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cecropin, diptera (IPR020400)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57028   AF019007 AAB82504   AF019008 AAB82505   AF019009 AAB82506   AF019010 AAB82507   AF019011 AAB82508   AF019012 AAB82509   AF019013 AAB82510   AF019014 AAB82511   AF019015 AAB82512   AF019016 AAB82513   AF019017 AAB82514   AF019018 AAB82515   AY113583 AAM29588   BI567466   BI575963   BI576902   BI583302   BI587847   BI588692   CA803392   CA803393   CA803611   CA805332   CA805458   CA805719   CA805737   CA805998   CA807807   Z11167 CAA77559
UniProtKB/Swiss-Prot	O16829
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000279    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000279 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000279 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr    13930 white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2  (936) larva L3 puffstage 3-6  (601) larva L3 puffstage 7-9  (149) white prepupae new  (435) white prepupae 12hr  (13930) white prepupae 24hr  (1475) pupae 2d postWPP  (1228) pupae 3d postWPP  (228) pupae 4d postWPP  (112) adult male 01day  (153) adult male 05day    45 adult male 30day  (125) adult female 01day  (385) adult female 05day  (183) adult female 30day  (810) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr  (13930) white prepupae 24hr  1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr  (13930) white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr    13930 white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000279 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr    13930 white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2  (936) larva L3 puffstage 3-6  (601) larva L3 puffstage 7-9  (149) white prepupae new  (435) white prepupae 12hr  (13930) white prepupae 24hr  (1475) pupae 2d postWPP  (1228) pupae 3d postWPP  (228) pupae 4d postWPP  112 adult male 01day  (153) adult male 05day    45 adult male 30day  125 adult female 01day  (385) adult female 05day  (183) adult female 30day  (810) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr  (13930) white prepupae 24hr  1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr  13930 white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    15 embryo 10-12hr    46 embryo 12-14hr    38 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    30 embryo 20-22hr    24 embryo 22-24hr    33 larva L1    5 larva L2    13 larva L3 12hr old    96 larva L3 puffstage 1-2    936 larva L3 puffstage 3-6    601 larva L3 puffstage 7-9    149 white prepupae new    435 white prepupae 12hr    13930 white prepupae 24hr    1475 pupae 2d postWPP    1228 pupae 3d postWPP    228 pupae 4d postWPP    112 adult male 01day    153 adult male 05day    45 adult male 30day    125 adult female 01day    385 adult female 05day    183 adult female 30day    810 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000279    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000279 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000279 expression level Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000279 expression level Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland  1635.3 Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body no informative data Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    8.7   24.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.6   NA  Crop    8.4   no informative data  Midgut    2.4   no informative data  Hindgut    5.5   no informative data  Malpighian Tubules    3.8   no informative data  Fat Body    no informative data   1635.3  Salivary Gland    454.2   NA  Heart    65.8   8.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.3   NA  Ovary    2.5   NA  Testis    1.2   NA  Male Accessory Gland    7.9   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000279 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1373-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CecC Class Mutagen Stocks Known lesion CecCMB01213 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CecC Class Mutagen Stocks Known lesion CecCGD3968 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)R113 (Clark and Wang, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3968} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CecCMB01213 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Tryselius et al., 1992) defense response to Gram-negative bacterium inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) defense response to Gram-positive bacterium inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) inferred from expression pattern (Gordon et al., 2008) humoral immune response inferred from expression pattern (Verleyen et al., 2006)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) extracellular space inferred from direct assay (Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) defense response to bacterium non-traceable author statement (Lemaitre, 2000.12.20) traceable author statement (Meister et al., 2000) defense response to fungus non-traceable author statement (Lemaitre, 2000.12.20) defense response to Gram-negative bacterium non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) defense response to Gram-positive bacterium non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CecC allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000279 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43599
Orthologs
Genome-wide drosophilid orthologs	Dsec\CecC Dsim\CecC
Curated drosophilid orthologs	Dere\CecC   Dmau\CecC   Dore\CecC   Dpse\CecV   Dsec\CecC   Dsim\CecC   Dtak\CecC (Date-Ito, 2000.8.8) Dtei\CecC   Dvir\Cec1   Dvir\Cec2A   Dvir\Cec2B   Dvir\Cec3   Dyak\CecC
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004223-PA Aedes aegypti (mosquito) AGAP000693-PA Anopheles gambiae (mosquito) CPIJ010701 Culex pipens (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240590 FBgn0228703 FBgn0228701 FBgn0216130 FBgn0216129 FBgn0216128 FBgn0216126 FBgn0017817 FBgn0017815 FBgn0017816 FBgn0015675 FBgn0046915 FBgn0025038 FBgn0046928 FBgn0025652 FBgn0243554 FBgn0243543 FBgn0243529 FBgn0243530 FBgn0243532 FBgn0145986 FBgn0000278 FBgn0130786 FBgn0130664 FBgn0126620 FBgn0126619 FBgn0126618 FBgn0125887 FBgn0260774 FBgn0104245 FBgn0104035 FBgn0095844 FBgn0095846 FBgn0093212 CPIJ010701 BGIBMGA014285 BGIBMGA006280 BGIBMGA000037 BGIBMGA000038 BGIBMGA000036 BGIBMGA000023 BGIBMGA000024 BGIBMGA000020 BGIBMGA000021 CEC2 CEC1 CECB
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	23177 y1 w67c23; Mi{ET1}CecCMB01213
Genomic Clones ( 2 )
	BACR05L15 BACR08B24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH33561
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH21864 RH28737 RH30093 RH32391 RH37866
Other clones	ESG011d.E7.1_E01 ESG011d.E7.1_E02 ESG011d.E21_B10 ESG019c.E21_G09 ESG0117c.B21_H09 ESG0118b.B21_C10 ESG0119b.B21_F09 ESG0119c.B21_A05 ESG0120c.B21_F04
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43599
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CecC CG1373 (Ye, 1999.11)
Source for database merge of	Source for merge of: CecC BcDNA:RH33561 (FlyBase, 1996-)
Additional comments	Source for merge of CecC BcDNA:RH33561 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) One of four structural genes for four very similar cecropin proteins (cecropin A1, A2, B and C), bacteriocidal proteins that are induced in adults in response to bacterial infection. (Lindsley and Zimm, 1992) CecA2 and CecC show a moderate transcriptional response to bacterial lipopolysaccharide and bacterial flagellin in Schneider cells, but no response in Kc cells. (Samakovlis et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079852 RefSeq (Proteins) • NP_524591 DDBJ / EMBL / GenBank • AAB82504 AAB82505 AAB82506 AAB82507 AAB82508 AAB82509 AAB82510 AAB82511 AAB82512 AAB82513 AAB82514 AAB82515 AAF57028 AAM29588 AF019007 AF019008 AF019009 AF019010 AF019011 AF019012 AF019013 AF019014 AF019015 AF019016 AF019017 AF019018 AY113583 BI576902 CAA77559 Z11167 Entrez Gene - A searchable database of RefSeq genes. • 43599 UniProtKB/Swiss-Prot • O16829
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cecropin, diptera (IPR020400)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000279 DRSC - Results from RNAi screens. • FBgn0000279 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000279 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1373-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43599 InParanoid A subset of ortholog calls from InParanoid. • AAEL004223-PA Aedes aegypti (mosquito) AGAP000693-PA Anopheles gambiae (mosquito) CPIJ010701 Culex pipens (mosquito) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43599 modMine - Data generated by the modENCODE project. • FBgn0000279 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0240590 FBgn0228703 FBgn0228701 FBgn0216130 FBgn0216129 FBgn0216128 FBgn0216126 FBgn0017817 FBgn0017815 FBgn0017816 FBgn0015675 FBgn0046915 FBgn0025038 FBgn0046928 FBgn0025652 FBgn0243554 FBgn0243543 FBgn0243529 FBgn0243530 FBgn0243532 FBgn0145986 FBgn0000278 FBgn0130786 FBgn0130664 FBgn0126620 FBgn0126619 FBgn0126618 FBgn0125887 FBgn0260774 FBgn0104245 FBgn0104035 FBgn0095844 FBgn0095846 FBgn0093212 CPIJ010701 BGIBMGA014285 BGIBMGA006280 BGIBMGA000037 BGIBMGA000038 BGIBMGA000036 BGIBMGA000023 BGIBMGA000024 BGIBMGA000020 BGIBMGA000021 CEC2 CEC1 CECB
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BcDNA:RH33561   Cec (Gottar et al., 2002, Engstrom et al., 2001, Ryu et al., 2008, Ren et al., 2007) cec (Comeron and Kreitman, 2000, Abdelsadik and Roeder, 2010) CecC (Waterhouse et al., 2007, Sackton and Clark, 2009, Date-Ito et al., 2002, Kim et al., 2007, Sackton et al., 2007, Becker et al., 2010, Pauli et al., 2010, Radyuk et al., 2010, Gerbasi et al., 2011, Jumbo-Lucioni et al., 2010) cecC (McDonald and Rosbash, 2001, Lemaitre, 2000.12.20, Jin et al., 2009, Zsindely et al., 2009) Cec-C (Przeworski et al., 2001, Andolfatto, 2001, Andolfatto and Przeworski, 2000) CG1373 (Irving et al., 2001, De Gregorio et al., 2001, Pal et al., 2007, Liu et al., 2006, Verleyen et al., 2006, Hernandez-Romano et al., 2008)
Name Synonym	Cecropin (Steiner, 2004, Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Wiklund et al., 2002, Kimbrell and Beutler, 2001, Rutschmann et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Govind, 1999, Han et al., 1998, Mathey-Prevot and Perrimon, 1998, Roos et al., 1997, Ryu et al., 2008, Ligoxygakis et al., 2002, Costa et al., 2009, Zhao et al., 2010) cecropin (Leclerc and Reichhart, 2004, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Ando et al., 1999, Hoffmann et al., 1999, Meng et al., 1999, Hoffmann, 1997, Zelinger and Heifetz, 2006, Zhou et al., 2005, Persson et al., 2007) cecropin C (Meister et al., 2000, Radyuk et al., 2010) Cecropin C (Pal et al., 2007, Matova and Anderson, 2006, Date-Ito et al., 2002, Kim et al., 2007, Lai et al., 2007, Flatt et al., 2008, Verleyen et al., 2006, Beckstead et al., 2005, Becker et al., 2010, Gordon et al., 2008) Cecropin-C precursor (Hernandez-Romano et al., 2008)
Secondary FlyBase IDs
	FBgn0062945
References ( 101 )
Generate a list of	All references relating to this gene ( 101 )
List References by type	Research paper  ( 56 ) Supplementary material  ( 3 ) Review  ( 20 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 1 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 7 )
	Gerbasi et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(8): 3204--3209 Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. [FBrf0213185] Abdelsadik and Roeder, 2010, BMC Genomics 11: 265 Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes. [FBrf0214863] Becker et al., 2010, Nature 463(7279): 369--373 FOXO-dependent regulation of innate immune homeostasis. [FBrf0209804] Jumbo-Lucioni et al., 2010, BMC Genomics 11: 297 Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. [FBrf0210956] Pauli et al., 2010, Curr. Biol. 20(20): 1787--1798 A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. [FBrf0212124] Radyuk et al., 2010, Biochim. biophys. Acta 1800(11): 1153--1163 Peroxiredoxin 5 modulates immune response in Drosophila. [FBrf0211669] Zhao et al., 2010, PLoS ONE 5(7): e11701 Experimental selection for Drosophila survival in extremely high o(2) environments. [FBrf0211379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...