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Gene Dmel\CecC

General Information
Symbol	Dmel\CecC	Species	D. melanogaster
Name	Cecropin C	Annotation symbol	CG1373
Feature type	protein_coding_gene	FlyBase ID	FBgn0000279
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	Cec, Cec-C
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99E2-99E2	Sequence location	3R:26,042,206..26,042,660 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cecropin C is referred to in FlyBase by the symbol Dmel\CecC (CG1373, FBgn0000279). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: defense response to Gram-negative bacterium; humoral immune response; defense response to Gram-positive bacterium; antibacterial humoral response. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cecropin; Cecropin, diptera. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1632719_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CecC. Gene sequence location is 3R:26042206..26042660.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Cec: Cecropin Three structural genes for three very similar cecropin proteins (cecropin A1, A2, and B), bacteriacidal proteins that are induced in adults in response to bacterial infection. All three cecropin genes are coordinately induced by injection of bacteria, although the B gene is expressed at a much lower level. Levels appreciable within one hour, peak at 6 hours and have generally returned to base line by 24 hours. Cecropins also induced by ingested bacteria.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99E2-99E2   Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CecC for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CecC-RA FBtr0085616  NM_079852   386   63
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CecC-PA   FBpp0084980   6.8   63   11.21     NP_524591   AAF57028
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cecropin, diptera (IPR020400) Cecropin (IPR000875)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57028   AF019007 AAB82504   AF019008 AAB82505   AF019009 AAB82506   AF019010 AAB82507   AF019011 AAB82508   AF019012 AAB82509   AF019013 AAB82510   AF019014 AAB82511   AF019015 AAB82512   AF019016 AAB82513   AF019017 AAB82514   AF019018 AAB82515   AY113583 AAM29588   BI567466   BI575963   BI576902   BI583302   BI587847   BI588692   CA803392   CA803393   CA803611   CA805332   CA805458   CA805719   CA805737   CA805998   CA807807   Z11167 CAA77559
UniProtKB/Swiss-Prot	O16829
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) extracellular space inferred from direct assay (Liu et al., 2006, Verleyen et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland  (1635.3) Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland  1635.3 Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    24.925 Larval Midgut    11.5 Larval Hindgut    10.5 Larval Malpighian Tubules    17.7 Larval Fat Body    34 Larval Salivary Gland    1635.3 Larval Trachea    8.675 Larval Carcass    18.225 Adult Head    69.4 Adult Eye    15.375 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    3.6 Adult Crop    8.4 Adult Midgut    2.4 Adult Hindgut    5.5 Adult Malpighian Tubules    3.8 Adult Fat Body    19.2 Adult Salivary Gland    454.2 Adult Heart    65.8 Adult VirginFemale Spermatheca    17.3 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    2.5 Adult Testis    1.2 Adult Male Accessory Gland    7.9 Adult Carcass    29.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    8.7   24.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.6   NA  Crop    8.4   no informative data  Midgut    2.4   no informative data  Hindgut    5.5   no informative data  Malpighian Tubules    3.8   no informative data  Fat Body    no informative data   1635.3  Salivary Gland    454.2   NA  Heart    65.8   8.675  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    9.3   NA  Ovary    2.5   NA  Testis    1.2   NA  Male Accessory Gland    7.9   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    397 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8    740 carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult    168 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8  (29) head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female  (60) head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female  (56) head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male  (59) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (397) digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (57) fat body, white prepupae    9 fat body, pupae P8  (740) carcass, larvae L3 wandering    5 carcass, 1-day adult  (50) carcass, 4-day adult  (49) carcass, 20-day adult  (168) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (397) digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8  (740) carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult  (168) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    397 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8    740 carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult    168 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    397 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8    740 carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult    168 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8  29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female  (60) head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female  (56) head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male  (59) salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (397) digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (57) fat body, white prepupae    9 fat body, pupae P8  (740) carcass, larvae L3 wandering    5 carcass, 1-day adult  (50) carcass, 4-day adult  (49) carcass, 20-day adult  (168) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae  (397) digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8  (740) carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult  (168) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    4 central nervous system, pupae P8    29 head, virgin 1-day female    6 head, virgin 4-day female    17 head, virgin 20-day female    60 head, mated 1-day female    3 head, mated 4-day female    9 head, mated 20-day female    56 head, mated 1-day male    1 head, mated 4-day male    5 head, mated 20-day male    59 salivary gland, larvae L3 wandering    22 salivary gland, white prepupae    397 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    7 digestive system, 4-day adult    1 digestive system, 20-day adult    8 fat body, larvae L3 wandering    57 fat body, white prepupae    9 fat body, pupae P8    740 carcass, larvae L3 wandering    5 carcass, 1-day adult    50 carcass, 4-day adult    49 carcass, 20-day adult    168 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr    183 white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr  (183) white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr  (183) white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr    183 white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr    183 white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr  (183) white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr  (183) white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    1 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    2 white prepupae new    6 white prepupae 12hr    183 white prepupae 24hr    19 pupae 2d postWPP    16 pupae 3d postWPP    3 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    5 adult female 05day    2 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    263 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    467 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4  (42) embryonic 1182-4H  (36) embryonic GM2    0 embryonic Kc167    0 embryonic S1  (51) embryonic S3    0 leg disc CME L1  (31) wing disc CME-W2  (56) wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (263) mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1  (467) CNS ML-DmBG2-c2  (68) tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (263) mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1  (467) CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    263 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    467 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    263 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    467 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4  (42) embryonic 1182-4H  (36) embryonic GM2    0 embryonic Kc167    0 embryonic S1  (51) embryonic S3    0 leg disc CME L1  31 wing disc CME-W2  (56) wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (263) mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1  (467) CNS ML-DmBG2-c2  (68) tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5  (263) mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1  (467) CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    22 Schneider line 2 Sg4    42 embryonic 1182-4H    36 embryonic GM2    0 embryonic Kc167    0 embryonic S1    51 embryonic S3    0 leg disc CME L1    31 wing disc CME-W2    56 wing disc ML-DmD8    20 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    0 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    263 mixed discs ML-DmD4-c1    4 CNS ML-DmBG1-c1    467 CNS ML-DmBG2-c2    68 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    278 Ethanol 10% 3 hrs, larvae L3    164 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    228 Rotenone 8 μg 12 hrs, larvae L3    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3  (43) Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (278) Ethanol 10% 3 hrs, larvae L3  (164) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3  (228) Rotenone 8 μg 12 hrs, larvae L3  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (278) Ethanol 10% 3 hrs, larvae L3  (164) Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3  (228) Rotenone 8 μg 12 hrs, larvae L3  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    278 Ethanol 10% 3 hrs, larvae L3    164 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    228 Rotenone 8 μg 12 hrs, larvae L3    131 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    278 Ethanol 10% 3 hrs, larvae L3    164 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    228 Rotenone 8 μg 12 hrs, larvae L3    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3  (43) Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (278) Ethanol 10% 3 hrs, larvae L3  (164) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (88) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3  (228) Rotenone 8 μg 12 hrs, larvae L3  (131) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3  (278) Ethanol 10% 3 hrs, larvae L3  (164) Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3  (228) Rotenone 8 μg 12 hrs, larvae L3  131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    43 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    278 Ethanol 10% 3 hrs, larvae L3    164 Caffeine 1.5 mg/ml 4 hrs, larvae L3    88 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    228 Rotenone 8 μg 12 hrs, larvae L3    131 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RH33561 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000279 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1373-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CecC Class Mutagen Stocks Known lesion CecCMB01213 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CecC Class Mutagen Stocks Known lesion CecCGD3968 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)R113 (Clark and Wang, 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3968} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CecCMB01213 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from direct assay (Tryselius et al., 1992) defense response to Gram-negative bacterium inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) defense response to Gram-positive bacterium inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) inferred from expression pattern (Gordon et al., 2008) humoral immune response inferred from expression pattern (Verleyen et al., 2006)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (assigned by UniProtKB) (Tryselius et al., 1992) extracellular space inferred from direct assay (Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) defense response to bacterium non-traceable author statement (Lemaitre, 2000.12.20) traceable author statement (Meister et al., 2000) defense response to fungus non-traceable author statement (Lemaitre, 2000.12.20) defense response to Gram-negative bacterium non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) defense response to Gram-positive bacterium non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CecC allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000279 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43599
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M39WG Dipteran inclusive ortholog search EOG60S0RF Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6M39WG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CecA2     Drosophila melanogaster fruit fly  Dmel\CecC     Drosophila melanogaster fruit fly  Dmel\CecA1     Drosophila simulans   Dsim\CecA1   Y Drosophila simulans   Dsim\CecC Y Y Drosophila sechellia   Dsec\CecA1   Y Drosophila sechellia   Dsec\CecC Y Y Drosophila erecta   Dere\GG11739   Y Drosophila yakuba   Dyak\GE10866   Y Drosophila yakuba   Dyak\GE10867   Y Drosophila ananassae   Dana\GF18827   Y Drosophila pseudoobscura pseudoobscura   Dpse\CecI   Y Drosophila willistoni   Dwil\GK14120   Y Drosophila willistoni   Dwil\GK14123   Y Drosophila willistoni   Dwil\GK14124   Y Drosophila virilis   Dvir\Cec2A   Y Drosophila virilis   Dvir\Cec3   Y Drosophila virilis   Dvir\Cec1   Y Drosophila virilis   Dvir\Cec2B   Y Drosophila mojavensis   Dmoj\GI23259   Y Drosophila grimshawi   Dgri\GH19151   Y Drosophila grimshawi   Dgri\GH19153   Y Drosophila grimshawi   Dgri\GH23329   Y Drosophila grimshawi   Dgri\GH19152   Y Drosophila grimshawi   Dgri\GH18419   Y Drosophila grimshawi   Dgri\GH23207   Y
Orthologs in non-Drosophila Dipterans (EOG60S0RF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004223 Y Anopheles gambiae Malaria mosquito  Agam\CecC Y Anopheles gambiae Malaria mosquito  Agam\CecA Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010701 Y
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (2) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\CecC Drosophila sechellia Dsec\CecC
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	23177 y1 w67c23; Mi{ET1}CecCMB01213
Genomic Clones ( 2 )
	BACR05L15 BACR08B24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH33561
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH21864 RH28737 RH30093 RH32391 RH37866
Other clones	ESG011d.E7.1_E01 ESG011d.E7.1_E02 ESG011d.E21_B10 ESG019c.E21_G09 ESG0117c.B21_H09 ESG0118b.B21_C10 ESG0119b.B21_F09 ESG0119c.B21_A05 ESG0120c.B21_F04
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43599
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CecC CG1373 (Ye, 1999.11)
Source for database merge of	Source for merge of: CecC BcDNA:RH33561 (FlyBase, 1996-)
Additional comments	Source for merge of CecC BcDNA:RH33561 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) One of four structural genes for four very similar cecropin proteins (cecropin A1, A2, B and C), bacteriocidal proteins that are induced in adults in response to bacterial infection. (Lindsley and Zimm, 1992) CecA2 and CecC show a moderate transcriptional response to bacterial lipopolysaccharide and bacterial flagellin in Schneider cells, but no response in Kc cells. (Samakovlis et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079852 RefSeq (Proteins) • NP_524591 DDBJ / EMBL / GenBank • AAB82504 AAB82505 AAB82506 AAB82507 AAB82508 AAB82509 AAB82510 AAB82511 AAB82512 AAB82513 AAB82514 AAB82515 AAF57028 AAM29588 AF019007 AF019008 AF019009 AF019010 AF019011 AF019012 AF019013 AF019014 AF019015 AF019016 AF019017 AF019018 AY113583 BI576902 CAA77559 Z11167 Entrez Gene - A searchable database of RefSeq genes. • 43599 UniProtKB/Swiss-Prot • O16829
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cecropin, diptera (IPR020400) Cecropin (IPR000875) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH33561
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000279 DRSC - Results from RNAi screens. • FBgn0000279 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000279 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1373-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000279 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43599 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43599 modMine - Data generated by the modENCODE project. • FBgn0000279
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	BcDNA:RH33561   Cec (Gottar et al., 2002, Engstrom et al., 2001, Ryu et al., 2008, Ren et al., 2007) cec (Comeron and Kreitman, 2000, Abdelsadik and Roeder, 2010) CecC (Waterhouse et al., 2007, Sackton and Clark, 2009, Date-Ito et al., 2002, Kim et al., 2007, Sackton et al., 2007, Becker et al., 2010, Pauli et al., 2010, Radyuk et al., 2010, Gerbasi et al., 2011, Jumbo-Lucioni et al., 2010) cecC (McDonald and Rosbash, 2001, Lemaitre, 2000.12.20, Jin et al., 2009, Zsindely et al., 2009) Cec-C (Przeworski et al., 2001, Andolfatto, 2001, Andolfatto and Przeworski, 2000) CG1373 (Irving et al., 2001, De Gregorio et al., 2001, Pal et al., 2007, Liu et al., 2006, Verleyen et al., 2006, Hernandez-Romano et al., 2008)
Name Synonym	Cecropin (Steiner, 2004, Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Wiklund et al., 2002, Kimbrell and Beutler, 2001, Rutschmann et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Govind, 1999, Han et al., 1998, Mathey-Prevot and Perrimon, 1998, Roos et al., 1997, Ryu et al., 2008, Moule et al., 2010, Ligoxygakis et al., 2002, Costa et al., 2009, Zhao et al., 2010) cecropin (Leclerc and Reichhart, 2004, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Ando et al., 1999, Hoffmann et al., 1999, Meng et al., 1999, Hoffmann, 1997, Zelinger and Heifetz, 2006, Zhou et al., 2005, Persson et al., 2007) cecropin C (Meister et al., 2000, Overend et al., 2012, Radyuk et al., 2010) Cecropin C (Pal et al., 2007, Matova and Anderson, 2006, Date-Ito et al., 2002, Ragab et al., 2011, Kim et al., 2007, Lai et al., 2007, Flatt et al., 2008, Verleyen et al., 2006, Beckstead et al., 2005, Becker et al., 2010, Longworth et al., 2012, Gordon et al., 2008, Felix et al., 2012) Cecropin-C precursor (Hernandez-Romano et al., 2008)
Secondary FlyBase IDs
	FBgn0062945
References ( 107 )
Generate a list of	All references relating to this gene ( 107 )
List References by type	Research paper  ( 62 ) Supplementary material  ( 3 ) Review  ( 20 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 1 )
Recent research papers ( 6 )
	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Longworth et al., 2012, PLoS Genet. 8(4): e1002618 A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity. [FBrf0218058] Overend et al., 2012, Peptides 34(1): 209--218 The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. [FBrf0217783] Rancès et al., 2012, PLoS Pathog. 8(2): e1002548 The relative importance of innate immune priming in wolbachia-mediated dengue interference. [FBrf0217657] Gerbasi et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(8): 3204--3209 Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. [FBrf0213185] Ragab et al., 2011, EMBO J. 30(6): 1123--1136 Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells. [FBrf0213275] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...