• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Cp190

General Information
Symbol	Dmel\Cp190	Species	D. melanogaster
Name	Centrosomal protein 190kD	Annotation symbol	CG6384
Feature type	protein_coding_gene	FlyBase ID	FBgn0000283
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Rb188, dmap190, CEN190, CP-190, Bx63
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88E9-88E11	Sequence location	3R:11,096,154..11,100,963 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Centrosomal protein 190kD is referred to in FlyBase by the symbol Dmel\Cp190 (CG6384, FBgn0000283). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding; microtubule binding; protein binding; DNA binding; chromatin insulator sequence binding. There is experimental evidence that it is involved in the biological process: nuclear axial expansion. 37 alleles are reported. The phenotypes of these alleles are annotated with: centrosome; microtubule; cleavage nucleus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631940_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Cp190. Gene sequence location is 3R:11096154..11100963.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E9-88E11   Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cp190 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cp190-RA FBtr0083126  NM_079635   4114   1096 Cp190-RB FBtr0083127  NM_169632   4176   1096
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Whitfield et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cp190-PA   FBpp0082580   121.7   1096   4.29     NP_524359   AAF55159 Cp190-PB   FBpp0082581   121.7   1096   4.29     NP_731998   AAN13643
Additional Polypeptide Data & Comments
Reported size (kDa)	185 (kD) (Whitfield et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201553   AA201898   AA202220   AA202620   AA263327   AA390436   AA390543   AA392344   AA439310   AA440189   AA440701   AA567674   AA695050   AA735482   AA816931   AA817460   AA820938   AA942454   AA942461   AA948851   AA949342   AA950047   AA951062   AE014297 AAF55159   AE014297 AAN13643   AI456879   AI456997   AI457075   AI511687   AI511693   AI515569   AI515602   AI518148   AI531076   AI531180   AI532177   AI532674   AI533381   AI533383   AI541906   AI543869   AI546252   AI546487   AW941502   BG636326   BI164646   BI165847   BI353370   BI358341   BI367338   BI369885   BI371155   BI373641   BI485527   BI579101   BT010090 AAQ22559   CO154999   CO179511   CO189438   CO286656   CO293207   CO298517   CO318462   CO319369   CO320015   DN153949   EC057343   EC065398   EC067496   EC084780   EC216218   EC218152   EC218826   EC220081   EC225743   EC227516   EC233510   EC250137   EC261119   EC261969   EV583913   EV584784   EV587569   EV596950   EV599208   GH756002   GH761159   GH822469   GH827946   GH828616   GH834955   GH840246   GH875393   GH902484   GH902979   GH904902   GH915451   GH925509   GH930564   GH930997   GH931995   GH938341   Z50021 CAA90324
UniProtKB/Swiss-Prot	Q24478
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Whitfield et al., 1988) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 16     (Whitfield et al., 1988) Comment:reference states 0-16 hr AEL
Additional Descriptive Data
	Cp190 transcripts are detected throughout development with the highest levels in 0-16 hr embryos and adult females. (Whitfield et al., 1988)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference blastoderm stage     (Whitfield et al., 1988)
Additional Descriptive Data
	Cp190 protein is found in centrosomes of mitotically active nuclei. (Whitfield et al., 1988)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centrosome inferred from direct assay (Whitfield et al., 1988, Prigent et al., 2005, Butcher et al., 2004, Chodagam et al., 2005) inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Oegema et al., 1997) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Butcher et al., 2004) inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Oegema et al., 1997) polytene chromosome inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Pai et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (803.275) Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland  (573.6) Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain  (558.1) Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary  (999.1) Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland  573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain  558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary  (999.1) Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    255.1   NA  Eye    276.125   NA  Brain    558.1   803.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    327   NA  Crop    295.8   185.9  Midgut    215   234.1  Hindgut    230.5   227.8  Malpighian Tubules    382.8   225.2  Fat Body    193.9   573.6  Salivary Gland    366   NA  Heart    236.475   494.575  Trachea    NA   NA  VirginFemale Spermatheca    226.7   NA  InseminatedFemale Spermatheca    246.4   NA  Ovary    999.1   NA  Testis    80.8   NA  Male Accessory Gland    231   284.175  Carcass    204.4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3    157 central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female    214 ovary, mated 4-day female    276 testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (79) central nervous system, larvae L3  (157) central nervous system, pupae P8  (60) head, virgin 1-day female  (33) head, virgin 4-day female  (37) head, virgin 20-day female    24 head, mated 1-day female  (39) head, mated 4-day female  (35) head, mated 20-day female    24 head, mated 1-day male  (44) head, mated 4-day male  (53) head, mated 20-day male  (57) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  26 digestive system, larvae L3 wandering  (32) digestive system, 1-day adult    17 digestive system, 4-day adult  (34) digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae  (39) fat body, pupae P8  (38) carcass, larvae L3 wandering  (77) carcass, 1-day adult    22 carcass, 4-day adult  (38) carcass, 20-day adult  (28) ovary, virgin 4-day female  (214) ovary, mated 4-day female  (276) testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3  (157) central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female  (214) ovary, mated 4-day female  (276) testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3    157 central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female    214 ovary, mated 4-day female    276 testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3    157 central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female    214 ovary, mated 4-day female    276 testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (79) central nervous system, larvae L3  (157) central nervous system, pupae P8  (60) head, virgin 1-day female  (33) head, virgin 4-day female  (37) head, virgin 20-day female    24 head, mated 1-day female  (39) head, mated 4-day female  (35) head, mated 20-day female    24 head, mated 1-day male  (44) head, mated 4-day male  (53) head, mated 20-day male  (57) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  26 digestive system, larvae L3 wandering  32 digestive system, 1-day adult    17 digestive system, 4-day adult  (34) digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae  (39) fat body, pupae P8  (38) carcass, larvae L3 wandering  (77) carcass, 1-day adult    22 carcass, 4-day adult  (38) carcass, 20-day adult  28 ovary, virgin 4-day female  (214) ovary, mated 4-day female  (276) testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3  (157) central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female  (214) ovary, mated 4-day female  (276) testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    79 central nervous system, larvae L3    157 central nervous system, pupae P8    60 head, virgin 1-day female    33 head, virgin 4-day female    37 head, virgin 20-day female    24 head, mated 1-day female    39 head, mated 4-day female    35 head, mated 20-day female    24 head, mated 1-day male    44 head, mated 4-day male    53 head, mated 20-day male    57 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    26 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    17 digestive system, 4-day adult    34 digestive system, 20-day adult    23 fat body, larvae L3 wandering    15 fat body, white prepupae    39 fat body, pupae P8    38 carcass, larvae L3 wandering    77 carcass, 1-day adult    22 carcass, 4-day adult    38 carcass, 20-day adult    28 ovary, virgin 4-day female    214 ovary, mated 4-day female    276 testis, mated 4-day male    8 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    196 embryo 04-06hr    158 embryo 06-08hr    147 embryo 08-10hr    122 embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr  (196) embryo 04-06hr  (158) embryo 06-08hr  (147) embryo 08-10hr  (122) embryo 10-12hr  (56) embryo 12-14hr  (67) embryo 14-16hr  (50) embryo 16-18hr  (44) embryo 18-20hr  (27) embryo 20-22hr  (58) embryo 22-24hr  (52) larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (34) white prepupae new  (36) white prepupae 12hr  (34) white prepupae 24hr  (45) pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day  (37) adult female 05day  (72) adult female 30day  (72) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr  (196) embryo 04-06hr  (158) embryo 06-08hr  (147) embryo 08-10hr  (122) embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    196 embryo 04-06hr    158 embryo 06-08hr    147 embryo 08-10hr    122 embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    196 embryo 04-06hr    158 embryo 06-08hr    147 embryo 08-10hr    122 embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (109) embryo 02-04hr  (196) embryo 04-06hr  (158) embryo 06-08hr  (147) embryo 08-10hr  (122) embryo 10-12hr  (56) embryo 12-14hr  (67) embryo 14-16hr  (50) embryo 16-18hr  (44) embryo 18-20hr  27 embryo 20-22hr  (58) embryo 22-24hr  (52) larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  (34) white prepupae new  (36) white prepupae 12hr  (34) white prepupae 24hr  (45) pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day  (37) adult female 05day  (72) adult female 30day  (72) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  109 embryo 02-04hr  (196) embryo 04-06hr  (158) embryo 06-08hr  (147) embryo 08-10hr  122 embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    109 embryo 02-04hr    196 embryo 04-06hr    158 embryo 06-08hr    147 embryo 08-10hr    122 embryo 10-12hr    56 embryo 12-14hr    67 embryo 14-16hr    50 embryo 16-18hr    44 embryo 18-20hr    27 embryo 20-22hr    58 embryo 22-24hr    52 larva L1    19 larva L2    20 larva L3 12hr old    16 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    34 white prepupae new    36 white prepupae 12hr    34 white prepupae 24hr    45 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    13 adult male 01day    14 adult male 05day    15 adult male 30day    15 adult female 01day    37 adult female 05day    72 adult female 30day    72 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    133 wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    123 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1    114 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS    205 ovary OSC    155 ovary OSS    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (99) Schneider line 2 Sg4  (47) embryonic 1182-4H  (88) embryonic GM2  (80) embryonic Kc167  (56) embryonic S1  (86) embryonic S3  (96) leg disc CME L1  (98) wing disc CME-W2  (44) wing disc ML-DmD8  (82) wing disc ML-DmD9  (82) wing disc ML-DmD16-c3  (133) wing disc ML-DmD21  (29) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (123) eye-antennal disc ML-DmD11  (58) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (90) CNS ML-DmBG1-c1  (114) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (75) ovary fGS/OSS  (205) ovary OSC  (155) ovary OSS  (107) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3  (133) wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3  (123) eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1  (114) CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS  (205) ovary OSC  (155) ovary OSS  107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    133 wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    123 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1    114 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS    205 ovary OSC    155 ovary OSS    107 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    133 wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    123 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1    114 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS    205 ovary OSC    155 ovary OSS    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (99) Schneider line 2 Sg4  (47) embryonic 1182-4H  (88) embryonic GM2  (80) embryonic Kc167  (56) embryonic S1  (86) embryonic S3  (96) leg disc CME L1  (98) wing disc CME-W2  (44) wing disc ML-DmD8  (82) wing disc ML-DmD9  (82) wing disc ML-DmD16-c3  (133) wing disc ML-DmD21  29 wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (123) eye-antennal disc ML-DmD11  (58) antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (90) CNS ML-DmBG1-c1  (114) CNS ML-DmBG2-c2  (59) tumorous blood cells mbn2  (75) ovary fGS/OSS  (205) ovary OSC  (155) ovary OSS  (107) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3  133 wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3  123 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1  114 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS  (205) ovary OSC  (155) ovary OSS  107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    99 Schneider line 2 Sg4    47 embryonic 1182-4H    88 embryonic GM2    80 embryonic Kc167    56 embryonic S1    86 embryonic S3    96 leg disc CME L1    98 wing disc CME-W2    44 wing disc ML-DmD8    82 wing disc ML-DmD9    82 wing disc ML-DmD16-c3    133 wing disc ML-DmD21    29 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    123 eye-antennal disc ML-DmD11    58 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    90 CNS ML-DmBG1-c1    114 CNS ML-DmBG2-c2    59 tumorous blood cells mbn2    75 ovary fGS/OSS    205 ovary OSC    155 ovary OSS    107 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult    178 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    168 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    128 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    162 Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (71) cold shock, 4-day adult  (54) heat shock, 4-day adult  (65) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (79) Cadmium 100 mM 48 hrs, 4-day adult  (178) Copper 0.5 mM 12 hrs, larvae L3  (31) Copper 15 mM 48 hrs, 4-day adult  (168) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (71) Ethanol 2.5% 3 hrs, larvae L3  (128) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (162) Caffeine 25 mg/ml 48 hrs, 4-day adult  (79) Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult  (83) Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult  (178) Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult  (168) Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3  (128) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (162) Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult    178 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    168 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    128 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    162 Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult    178 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    168 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    128 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    162 Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (71) cold shock, 4-day adult  (54) heat shock, 4-day adult  (65) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  (79) Cadmium 100 mM 48 hrs, 4-day adult  (178) Copper 0.5 mM 12 hrs, larvae L3  31 Copper 15 mM 48 hrs, 4-day adult  (168) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (71) Ethanol 2.5% 3 hrs, larvae L3  (128) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (162) Caffeine 25 mg/ml 48 hrs, 4-day adult  (79) Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult  (83) Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult  (178) Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult  (168) Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3  128 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (162) Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult  119 Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    71 cold shock, 4-day adult    54 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    79 Cadmium 100 mM 48 hrs, 4-day adult    178 Copper 0.5 mM 12 hrs, larvae L3    31 Copper 15 mM 48 hrs, 4-day adult    168 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    71 Ethanol 2.5% 3 hrs, larvae L3    128 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    21 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    162 Caffeine 25 mg/ml 48 hrs, 4-day adult    79 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    83 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD02352 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6384-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Cp190H31-2 Cp190H53-2 lethal | larval stage | partially (with Cp1901) Cp1902 lethal | larval stage | partially (with Cp1902) Cp1901 lethal | larval stage | partially (with Df(3R)P280-NR27) Cp1901 Cp1902 lethal | larval stage | partially | recessive Cp1901 Cp1902 lethal | partially | pupal stage | recessive Cp190Ubi-p63E.PB lethal | pharate adult stage (with Cp1901) Cp1902 lethal | pharate adult stage (with Cp1902) Cp1901 lethal | pharate adult stage (with Df(3R)P280-NR27) Cp1901 Cp1902 lethal | pharate adult stage | recessive Cp1901 Cp1902 lethal | pupal stage | recessive Cp190ΔM.Ubi-p63E viable Cp190CB04933 Cp190H4-1 viable, with Scer\GAL4pnr-MD237 Cp190GD11908 Phenotype manifest in Allele centrosome Cp190ΔM.Ubi-p63E cleavage nucleus Cp1902 microtubule Cp190ΔM.Ubi-p63E
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Cp190 Class Mutagen Stocks Known lesion Cp190EY20997 P-element activity 1 -- Cp190G5211 P-element activity 1 -- Cp1901 loss of function allele ethyl methanesulfonate 0 -- Cp1902 loss of function allele ethyl methanesulfonate 0 -- Cp190CB04933 P-element activity 0 Yes Cp190H31-2 ethyl methanesulfonate 0 Yes Cp190H4-1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Cp190H53-2 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cp190 Class Mutagen Stocks Known lesion Cp190GD11908 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cp190HMJ02105 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190HMS00845 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190HMS00895 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190KK105213 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190167-1090.T:Zzzz\His6 in vitro construct - coding region fusion 0 Yes Cp190167-271 in vitro construct 0 Yes Cp190167-321 in vitro construct 0 Yes Cp190167-468 in vitro construct 0 Yes Cp190167-608 in vitro construct 0 Yes Cp190207-321 in vitro construct 0 Yes Cp190207-608 in vitro construct 0 Yes Cp190240-321 in vitro construct 0 Yes Cp190240-608 in vitro construct 0 Yes Cp190266-608 in vitro construct 0 Yes Cp190309-427 in vitro construct 0 Yes Cp190309-456 in vitro construct 0 Yes Cp190309-608 in vitro construct 0 Yes Cp190385-508 in vitro construct 0 Yes Cp190421-608 in vitro construct 0 Yes Cp190428-608 in vitro construct 0 Yes Cp190451-608 in vitro construct 0 Yes Cp190504-789 in vitro construct 0 Yes Cp190646-937 in vitro construct 0 Yes Cp190784-1090 in vitro construct 0 Yes Cp190NIG.6384R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cp190Ubi-p63E.PB in vitro construct - regulatory fusion 0 Yes Cp190Δ175 in vitro construct 0 Yes Cp190ΔM.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)E(mod)4-1P1 (Pai et al., 2004) Df(3R)E(mod)4-1P11 (Pai et al., 2004) Df(3R)Exel7323 (Ryder, 2004.4.26) Df(3R)P280-NR27 (Butcher et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11908} NA P{KK105213} NA P{NIG.6384R} NA P{TRiP.HMJ02105} NA P{TRiP.HMS00845} NA P{TRiP.HMS00895} NA characterization construct P{Ubi-Cp190.D} NA P{Ubi-Cp190.ΔM} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Cp190G5211 NA P{EPgy2}Cp190EY20997 NA miscellaneous insertions P{PTT-GB}Cp190CB04933 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995) chromatin insulator sequence binding inferred from direct assay (Mohan et al., 2007) DNA binding inferred from direct assay (assigned by UniProtKB) (Pai et al., 2004) microtubule binding inferred from direct assay (Butcher et al., 2004) inferred from direct assay (assigned by UniProtKB) (Raff et al., 1993) protein binding inferred from physical interaction with UniProtKB:P08970 (assigned by UniProtKB) (Pai et al., 2004) inferred from physical interaction with UniProtKB:Q86B87 (assigned by UniProtKB) (Pai et al., 2004) inferred from physical interaction with UniProtKB:Q24147 (assigned by UniProtKB) (Kellogg and Alberts, 1992, Raff et al., 1993)
Biological Process
CV term Evidence References
nuclear axial expansion inferred from mutant phenotype (Chodagam et al., 2005)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Whitfield et al., 1988, Prigent et al., 2005, Butcher et al., 2004, Chodagam et al., 2005) inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Oegema et al., 1997) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Butcher et al., 2004) inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Oegema et al., 1997) polytene chromosome inferred from direct assay (assigned by UniProtKB) (Whitfield et al., 1995, Pai et al., 2004)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
centrosome non-traceable author statement (Whitfield, 1995.7.6) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cp190 - CG8436 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cp190 - Dredd anti tag coimmunoprecipitation, peptide massfingerprinting (Fukuyama et al., 2012)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cp190 allele Gene References unspecified mod(mdg4) (Pai et al., 2004) sqh (Chodagam et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66912 DroID - A comprehensive database of gene and protein interactions. • FBgn0000283 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41848 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24478
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BK5P7 Dipteran inclusive ortholog search EOG6MPHZ5 Insect inclusive ortholog search EOG6VX115 Arthropod inclusive ortholog search EOG6866TH Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6BK5P7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cp190     Drosophila simulans   Dsim\Cen190 Y   Drosophila sechellia   Dsec\GM11488 Y   Drosophila erecta   Dere\GG20737 Y   Drosophila yakuba   Dyak\Cen190 Y   Drosophila ananassae   Dana\GF11747 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19554 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28898     Drosophila persimilis   Dper\GL12069 Y   Drosophila persimilis   Dper\GL24758     Drosophila willistoni   Dwil\GK13490 Y   Drosophila virilis   Dvir\GJ24037 Y   Drosophila virilis   Dvir\GJ23433     Drosophila mojavensis   Dmoj\GI24664 Y   Drosophila grimshawi   Dgri\GH18747 Y   Drosophila grimshawi   Dgri\GH22244
Orthologs in non-Drosophila Dipterans (EOG6MPHZ5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002771   Anopheles gambiae Malaria mosquito  Agam\AGAP001794   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013368
Orthologs in non-Dipteran Insects (EOG6VX115)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.17411   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016275   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016273   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11535   Atta cephalotes Leafcutter ant  Acep\ACEP13098   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17181   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20465   Linepithema humile Argentine ant  Lhum\LH13036   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14388   Solenopsis invicta Red fire ant  Sinv\SINV17737   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003627   Bombyx mori Silkmoth  Bmor\BGIBMGA001575   Pediculus humanus Human body louse  Phum\PHUM234130   Tribolium castaneum Red flour beetle  Tcas\TC030585
Orthologs in non-Insect Arthropods (EOG6866TH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_219913
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Cen190 Drosophila sechellia Dsec\GM11488 Drosophila erecta Dere\GG20737 Drosophila yakuba Dyak\Cen190 Drosophila ananassae Dana\GF11747 Drosophila pseudoobscura pseudoobscura Dpse\GA19554 Drosophila persimilis Dper\GL12069 Drosophila willistoni Dwil\GK13490 Drosophila virilis Dvir\GJ24037 Drosophila mojavensis Dmoj\GI24664 Drosophila grimshawi Dgri\GH18747
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	31792 w1118; P{EP}Cp190G5211 42536 y1 v1; P{TRiP.HMJ02105}attP40 22440 y1 w67c23; P{EPgy2}Cp190EY20997 33903 y1 sc* v1; P{TRiP.HMS00845}attP2 33944 y1 sc* v1; P{TRiP.HMS00895}attP2/TM3, Sb1
VDRC	v108694 P{KK105213}VIE-260B v35077 w1118; P{GD11908}v35077 v35078 w1118; P{GD11908}v35078
Genomic Clones ( 2 )
	BACR13A02 BACR32A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02352
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02009 GM23328 HL01616 LD02848 LD03980 LD04376 LD06517 LD08796 LD09366 LD11188 LD13843 LD14803 LD15565 LD21393 LD21770 LD22923 LD24882 LD26683 LD26695 LD27517 LD28204 LD30001 LD31340 LD37038 LD37194 LD37328 LD37575 LD43170 LD43176 LD45532 LD47453 LD47491 LD47777 LD48072 RE04358 RE05828 RE45084 RE53080 RE56219 RE57986 RE60983 RE68874 RE73077 SD01963 SD02115 SD03572 SD04261 SD05168 SD05172 SD07866 SD13965
Other clones	35025 40342 108156 109090 167419 176697 191076 192646 524326 525067 CK01.15D.C12 CK01.54C.G6 CK01.76B.H10 CK01.125D.A8 Dmel_dig_014178_0683_2772 Dmel_dig_018438_0644_1184 Dmel_neb_012344_0917_1117 Dmel_neb_014504_0904_2589 Dmel_neb_014553_0113_2724 EK044259 EK059563 EK063506 EK139544 EK173157 EK202101 EK272217 EK277808 EK281725 EN05156 RP003049625 RP003062996 RP003089496 RP003236295 RP003252739 RP003293797 RP003328565 RP003329663 RP003335126 RP003371808 RP003374525 RP003451410 RP003451785 RP003466432 RP003474150 RP003524521 RP003570071
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41848
Antibody Information
	polyclonal (Moshkovich et al., 2011, Matzat et al., 2012, Whitfield et al., 1988, Wallace et al., 2010, Golovnin et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cen190 CG6384 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Cp190 protein in 0-12 hr embryos; see Insulator_Class_I.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245). (Nègre et al., 2010) Cp190 proteins can be modified by smt3. (Capelson and Corces, 2006) Map60 (Butcher et al., 2004) The introduction of dsRNA made from templates generated with primers directed against this gene into S2 cells prevents the accumulation of Map60 to mitotic centrosomes. (Butcher et al., 2004) Cp190 plays an essential role in flies that is independent of its association with centrosomes or microtubules. (Butcher et al., 2004) Cp190 mutations act as recessive suppressors of gypsy-induced phenotypes, suggesting that Cp190 is an essential component of the gypsy insulator. (Pai et al., 2004) Cp190 requires su(Hw) in order to bind to the insulator present in the gypsy retrotransposon, but su(Hw) is not necessary for the interaction of Cp190 with endogenous insulator sites. (Pai et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Fluorescently labelled bacterially expressed Cp190 is injected into living embryos and protein behaviour during the rapid syncytial blastoderm divisions (nuclear cycles 10-13) is followed. (Oegema et al., 1997) The localisation of Cp190 protein within the fertilised egg has been studied. (Riparbelli et al., 1997) The region between amino acids 385 and 508 of the Cp190 protein is sufficient for good centrosomal localisation. A nuclear localisation domain is located between amino acids 201 and 271. (Oegema et al., 1995) Cp190 is associated with the centrosome during mitosis and during interphase the protein is associated with a large number of specific chromosomal sites. Cp190 binds to chromatin in association with another centrosomal protein, Map60. (Whitfield et al., 1995) By using monoclonal antibodies that recognize protein components of the mitotic apparatus to screen expression libraries, Cen185, which encodes a protein associated with the centrosome, was cloned. (Whitfield et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079635 NM_169632 RefSeq (Proteins) • NP_524359 NP_731998 DDBJ / EMBL / GenBank • AA202220 AAF55159 AAN13643 AAQ22559 AW941502 BT010090 CAA90324 Z50021 Entrez Gene - A searchable database of RefSeq genes. • 41848 UniProtKB/Swiss-Prot • Q24478
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD02352
Linkouts
	BioGRID - A database of protein and genetic interactions • 66912 DroID - A comprehensive database of gene and protein interactions. • FBgn0000283 DRSC - Results from RNAi screens. • FBgn0000283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6384-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41848 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cp190.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41848 modMine - Data generated by the modENCODE project. • FBgn0000283 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24478
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	AbS1-4   Bx63 (Sunkel et al., 1995, Foe et al., 1993, ) Bx-63 (Semeshin et al., 2002) Cen185 (Whitfield et al., 1988) CEN190 (Izumi et al., 2004) Cen190 (Bauer-DuMont et al., 2004, Zraly et al., 2002, Li and Kaufman, 1996, Glover et al., 1995, Cambiazo et al., 1993, ) CG6384 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1) CP-60 (Vidwans and O'Farrell, 1999) CP190 (Bettencourt-Dias et al., 2005, Debec et al., 2001, Deak et al., 2003, Terada et al., 2003, Prigent et al., 2005, Kaltschmidt and Brand, 2002, Marshall, 2003, Staeva-Vieira et al., 2003, Riparbelli and Callaini, 2003, Fung et al., 2002, Begun, 2001, Nickerson, 2001, Donaldson et al., 2001, Loppin et al., 2001, Barbosa et al., 2000, Sisson et al., 2000, Goldstein and Gunawardena, 2000, Callaini et al., 1999, Johansen et al., 1999, Yucel et al., 2000, Lemos et al., 2000, Begun and Whitley, 2000, Brent et al., 2000, Kaltschmidt et al., 2000, Whitfield, 1995.7.6, Debec et al., 1999, Vaizel-Ohayon and Schejter, 1999, Cullen et al., 1999, Robinson et al., 1999, Oegema, 1998, Megraw et al., 1999, Avides and Glover, 1999, Llamazares et al., 1999, Gonzalez et al., 1998, Glover et al., 1998, Gonzalez et al., 1998, Moritz et al., 1998, Wilson and Borisy, 1998, Adams et al., 1998, Riparbelli and Callaini, 1998, Kodjabachian et al., 1998, Sibon et al., 1997, Reed and Orr-Weaver, 1997, Riparbelli et al., 1997, Oegema et al., 1997, Callaini et al., 1997, Ohkura et al., 1997, Sibon and Theurkauf, 1996, Philp and Glover, 1997, Frenz and Glover, 1996, Riparbelli and Callaini, 1996, Oegema et al., 1995, Whitfield et al., 1995, Moritz et al., 1995, Capelson and Corces, 2005, Lei, 2007, Akbari et al., 2007, Capelson and Corces, 2006, McHugh et al., 2004, Basto et al., 2006, Richter et al., 2011, Sultana et al., 2011, Pai et al., 2004, Barros et al., 2005, Cullen et al., 2005, Rodrigues-Martins et al., 2007, Mottier et al., 2008, Georgiev et al., 2008, Lei et al., 2008, Oliver, 2008, Akbari et al., 2008, Blagden and Glover, 2003, Gerasimova et al., 2007, Golovnin et al., 2007, Ramos et al., 2011, Erokhin et al., 2011, Bushey et al., 2009, Kalverda and Fornerod, 2010, Martins et al., 2010, Nègre et al., 2011, Bonchuk et al., 2011, Wood et al., 2011, Mohan et al., 2007, Raynaud-Messina et al., 2004, Riparbelli and Callaini, 2005, Basto et al., 2007, Rogers et al., 2008, Akbari et al., 2009, Meireles et al., 2009, Ducat et al., 2008, Schaaf et al., 2009, Lei and Corces, 2006, Rach et al., 2011, Nègre et al., 2010, van Bemmel et al., 2010, modENCODE Consortium et al., 2010, Schoborg and Labrador, 2010, Ma and Jarman, 2011, Wallace et al., 2010, Erokhin et al., 2010, Guertin and Lis, 2010, Vatolina et al., 2011, Vatolina et al., 2011, Gopalakrishnan et al., 2012, Sakoparnig et al., 2012, Demakov et al., 2011, Philip et al., 2012, Golovnin et al., 2012, Soshnev et al., 2012, Gurudatta et al., 2012) CP-190 (Stevenson et al., 2001, Helps et al., 1998, Matthies et al., 1996, Gopalakrishnan et al., 2011, Schaefer et al., 2008) Cp190 (Pai et al., 2004, Buszczak et al., 2007, Bakal et al., 2007, Baxley et al., 2011, Kwong et al., 2008, Toku et al., 2011, Bartkuhn et al., 2009, Oliver et al., 2010, Fisher et al., 2008, Japanese National Institute of Genetics, 2012.5.21, Maeng et al., 2012, Antao et al., 2012) CP190_DROME (Fukuyama et al., 2012) dmap190 (Craig and Brink, 1996) DMAP190 (McKim and Hawley, 1995, Oegema et al., 1994, Wilson and Fuller, 1994, Oegema et al., 1993, Kellogg and Alberts, 1992, Postner et al., 1992, ) Dmap190 (Endow et al., 1994, ) DMAP-190 (Moritz and Alberts, 1992) E(mod)4-1 (Pai et al., 2004) Map190   Rb188 (Ceron et al., 2001, Inoue et al., 2000, Audibert and Simonelig, 1999, Mathe et al., 1998, Callaini et al., 1994, Riparbelli and Callaini, 1992, Callaini and Riparbelli, 1992, Yasuda et al., 1991, ) unnamed (Goldstein and Gunawardena, 2000)
Name Synonym	Centrosomal Protein 90 (Bushey et al., 2009) Centrosomal Protein 190 (Pai et al., 2004) centrosomal protein 190 (Wood et al., 2011) Centrosomal protein 190kD (Ducat et al., 2008) Centrosomal protein 190 kDa (Nègre et al., 2011) Centrosomal Protein of 190 kDa (Soshnev et al., 2012) E(mod)4-1 (Pai et al., 2004) Enhancer of mod(mdg4)4-1 (Pai et al., 2004)
Secondary FlyBase IDs
	FBgn0014463
References ( 205 )
Generate a list of	All references relating to this gene ( 205 )
List References by type	Research paper  ( 146 ) Supplementary material  ( 7 ) Review  ( 11 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 19 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Note  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Conference report  ( 1 )
Recent research papers ( 30 )
	Lim et al., 2013, Nucleic Acids Res. 41(5): 2963--2980 Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. [FBrf0221054] Antao et al., 2012, Mol. Cell. Biol. 32(12): 2170--2182 Protein Landscape at Drosophila melanogaster Telomere-Associated Sequence Repeats. [FBrf0218429] Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619 On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Golovnin et al., 2012, J. Cell Sci. 125(8): 2064--2074 SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation. [FBrf0218398] Gopalakrishnan et al., 2012, Nat. Cell Biol. 14(8): 865--873 Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. [FBrf0219801] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Maeng et al., 2012, Mol. Cells 33(5): 457--463 The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. [FBrf0218378] Matzat et al., 2012, PLoS Genet. 8(11): e1003069 Tissue-specific regulation of chromatin insulator function. [FBrf0220170] Philip et al., 2012, BMC Genomics 13(1): 97 Sequence signatures involved in targeting the male-specific lethal complex to X-chromosomal genes in Drosophila melanogaster. [FBrf0218340] Riddle et al., 2012, PLoS Genet. 8(9): e1002954 Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain. [FBrf0219520] Sakoparnig et al., 2012, J. Comput. Biol. 19(2): 126--138 Binding profiles of chromatin-modifying proteins are predictive for transcriptional activity and promoter-proximal pausing. [FBrf0217402] Schwartz et al., 2012, Genome Res. 22(11): 2188--2198 Nature and function of insulator protein binding sites in the Drosophila genome. [FBrf0219925] Soshnev et al., 2012, Nucleic Acids Res. 40(12): 5415--5431 Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. [FBrf0218724] Baxley et al., 2011, Dev. Biol. 356(2): 398--410 The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis. [FBrf0214454] Bonchuk et al., 2011, J. Mol. Biol. 412(3): 423--436 Drosophila BTB/POZ Domains of "ttk Group" Can Form Multimers and Selectively Interact with Each Other. [FBrf0215054] Demakov et al., 2011, BMC Genomics 12: 566 Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. [FBrf0216974] Erokhin et al., 2011, Development 138(18): 4097--4106 Insulators form gene loops by interacting with promoters in Drosophila. [FBrf0214806] Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. [FBrf0216370] Ma and Jarman, 2011, J. Cell Sci. 124(15): 2622--2630 Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation. [FBrf0214370] Moshkovich et al., 2011, Genes Dev. 25(16): 1686--1701 RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. [FBrf0214686] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Rach et al., 2011, PLoS Genet. 7(1): e1001274 Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. [FBrf0214353] Ramos et al., 2011, PLoS ONE 6(1): e16562 DNA Topoisomerase II Modulates Insulator Function in Drosophila. [FBrf0213027] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sultana et al., 2011, Nucleic Acids Res. 39(9): 3543--3557 A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. [FBrf0213641] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. [FBrf0214456] Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster. [FBrf0216692] Wood et al., 2011, Mol. Cell 44(1): 29--38 Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. [FBrf0216321] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...