FB2025_05 , released December 11, 2025
Gene: Dmel\Cp190
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General Information
Symbol
Dmel\Cp190
Species
D. melanogaster
Name
Centrosomal protein 190kD
Annotation Symbol
CG6384
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000283
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Centrosomal protein 190kD (Cp190) encodes a BTB-ZnF transcription factor that has both nuclear and centrosomal functions. It's an insulator protein required to form physical and regulatory boundaries in the genome, and is recruited by DNA-binding proteins such as CTCF, su(Hw) and others, with which it physically associates. [Date last reviewed: 2023-11-16] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Rb188, DMAP190, Cen190, CP-190, Centrosomal Protein 190

Key Links
Genomic Location
Cytogenetic map
88E9-88E11
Sequence location
Recombination map
3-56
RefSeq locus
NT_033777 REGION:15270432..15275241
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Bag et al., 2019)
inferred from direct assay
(Whitfield et al., 1995)
enables chromatin insulator sequence binding
inferred from direct assay
(Erokhin et al., 2010, Oliver et al., 2010, Mohan et al., 2007)
inferred from direct assay
(Sokolov et al., 2024)
enables DNA binding
inferred from direct assay
(Ogiyama et al., 2018)
inferred from direct assay
(Pai et al., 2004)
enables microtubule binding
inferred from direct assay
(Plevock et al., 2015, Raff et al., 1993)
inferred from direct assay
(Butcher et al., 2004)
enables POZ domain binding
inferred from direct assay
(Bonchuk et al., 2011)
enables protein binding
inferred from physical interaction with FLYBASE:Sas-4; FB:FBgn0011020
(Gopalakrishnan et al., 2011)
inferred from physical interaction with UniProtKB:Q8SYK5
(Dai et al., 2015)
inferred from physical interaction with UniProtKB:P08970
(Pai et al., 2004)
inferred from physical interaction with UniProtKB:Q86B87
(Pai et al., 2004)
inferred from physical interaction with FLYBASE:Ibf2; FB:FBgn0037669
(Cuartero et al., 2014)
inferred from physical interaction with FLYBASE:Ibf1; FB:FBgn0037670
(Cuartero et al., 2014)
inferred from physical interaction with UniProtKB:Q9VCH5
(Pascual-Garcia et al., 2017)
inferred from physical interaction with UniProtKB:Q1LZ24
(Sokolov et al., 2024)
enables protein homodimerization activity
inferred from direct assay
(Plevock et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000694507
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in chromatin looping
inferred from mutant phenotype
(Wood et al., 2011)
involved_in heterochromatin boundary formation
inferred from genetic interaction with FLYBASE:w; FB:FBgn0003996
(Cuartero et al., 2014)
involved_in nuclear axial expansion
inferred from mutant phenotype
(Chodagam et al., 2005)
involved_in regulation of cytoskeleton organization
inferred from mutant phenotype
(Chodagam et al., 2005)
involved_in regulation of DNA-templated transcription
inferred from mutant phenotype
(Cuartero et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000694507
(GO Reference Genome Project, 2011-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in centrosome
inferred from direct assay
(Plevock et al., 2015, Chodagam et al., 2005, Prigent et al., 2005, Butcher et al., 2004, Whitfield et al., 1988)
inferred from direct assay
(Oegema et al., 1997, Whitfield et al., 1995)
located_in chromatin
inferred from direct assay
(Sokolov et al., 2024)
inferred from direct assay
(Bag et al., 2019)
located_in condensed chromosome
inferred from direct assay
(Plevock et al., 2015)
located_in nucleoplasm
inferred from direct assay
(Sokolov et al., 2024)
located_in nucleus
inferred from direct assay
(Bag et al., 2019, Cuartero et al., 2014, Akbari et al., 2009, Butcher et al., 2004)
inferred from direct assay
(Oegema et al., 1997, Whitfield et al., 1995)
located_in pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011)
located_in polytene chromosome band
inferred from direct assay
(Oliver et al., 2010)
located_in polytene chromosome
inferred from direct assay
(Pai et al., 2004, Whitfield et al., 1995)
inferred from direct assay
(Maksimenko et al., 2015, Akbari et al., 2009)
located_in spindle microtubule
inferred from direct assay
(Plevock et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000694507
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Centrosomal protein 190kD (Cp190) encodes a BTB-ZnF transcription factor that has both nuclear and centrosomal functions. It's an insulator protein required to form physical and regulatory boundaries in the genome, and is recruited by DNA-binding proteins such as CTCF, su(Hw) and others, with which it physically associates. [Date last reviewed: 2023-11-16]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Plays a central role in chromatin domain organization and boundary function through recruitment by a range of insulator DNA-binding proteins, including ZIPIC, pita, CTCF, su(Hw), cliff and others (PubMed:25342723, PubMed:33752739, PubMed:38769058). Together with pita and CTCF cooperatively binds to and regulates the activity of the Miscadastral pigmentation (MCP) insulator (PubMed:25342723). Cooperatively recruited to the front-ultraabdominal (Fub) boundary by pita, su(Hw) and cliff (PubMed:38769058). Recruitment of Cp190 together with Chro/chromator induces chromatin decondensation (PubMed:33752739). Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators (PubMed:15574329). Chromatin insulators are regulatory elements that establish independent domains of transcriptional activity within eukaryotic genomes (Probable). Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV) (Probable). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops to form topologically associating domains (TADs) (Probable). This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery (Probable). Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw) (PubMed:15574329). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo (PubMed:16051175). Associates with centrosomes and interphase microtubules during mitosis, and recruits CP60; may have a role in maintaining centrosome and spindle integrity (PubMed:14996941, PubMed:16051175, PubMed:26649574).
(UniProt, Q24478)
Summary (Interactive Fly)

BTB/POZ domain and microtubule binding protein that alternatively serves as a chromatin insulator and as a component of centrioles - involved in axial expansion, the spreading out along the anterior-to-posterior axis during syncytial development

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cp190 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q24478)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cp190-RA
FBtr0083126
NM_079635
4114
1096
Cp190-RB
FBtr0083127
NM_169632
4176
1096
Additional Transcript Data and Comments
Reported size (kB)

4.0 (northern blot)

(Whitfield et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cp190-PA
FBpp0082580
121.7
1096
4.29
Q24478
NP_524359
AAF55159
Cp190-PB
FBpp0082581
121.7
1096
4.29
Q24478
NP_731998
AAN13643
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1096 aa isoforms: Cp190-PA, Cp190-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

185 (kD)

(Whitfield et al., 1988)
Comments
External Data
Subunit Structure (UniProtKB)

Homodimerizes via the N-terminal BTB domain (PubMed:26649574). Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:15574329). Interacts with Cp60 (PubMed:8491775, PubMed:8590797, PubMed:9700165). Interacts with inv (PubMed:25561495). Interacts with Nup98 (PubMed:28366641). Interacts (via BTB domain) with pita (via region between the ZAD domain and the first zinc finger domain); the interaction is direct (PubMed:25342723, PubMed:33752739). Interacts with ZIPIC (via region between the ZAD domain and the first zinc finger domain); the interaction is direct (PubMed:25342723). Interacts (via regions between the BTB domain and first zinc finger domain) with cliff (via regions flanking MADF domain 1); the interaction is probably direct (PubMed:38769058). Associates (via N-terminus) with microtubules; the interaction is direct, is enhanced by dimerization and involves multiple regions within the N-terminus (PubMed:14996941, PubMed:26649574, PubMed:8491775, PubMed:8522588). Microtubule association is enriched at growing plus ends (PubMed:26649574).

(UniProt, Q24478)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cp190 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
(Whitfield et al., 1988)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 16

Comment: reference states 0-16 hr AEL

(Whitfield et al., 1988)
Additional Descriptive Data

Cp190 transcripts are detected throughout development with the highest levels in 0-16 hr embryos and adult females.

(Whitfield et al., 1988)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
blastoderm stage
(Whitfield et al., 1988)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data

Cp190 protein is detected in blastoderm embryos.

(Whitfield et al., 1988)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in centrosome
inferred from direct assay
(Plevock et al., 2015, Chodagam et al., 2005, Prigent et al., 2005, Butcher et al., 2004, Whitfield et al., 1988)
inferred from direct assay
(Oegema et al., 1997, Whitfield et al., 1995)
located_in chromatin
inferred from direct assay
(Sokolov et al., 2024)
inferred from direct assay
(Bag et al., 2019)
located_in condensed chromosome
inferred from direct assay
(Plevock et al., 2015)
located_in nucleoplasm
inferred from direct assay
(Sokolov et al., 2024)
located_in nucleus
inferred from direct assay
(Bag et al., 2019, Cuartero et al., 2014, Akbari et al., 2009, Butcher et al., 2004)
inferred from direct assay
(Oegema et al., 1997, Whitfield et al., 1995)
located_in pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011)
located_in polytene chromosome band
inferred from direct assay
(Oliver et al., 2010)
located_in polytene chromosome
inferred from direct assay
(Pai et al., 2004, Whitfield et al., 1995)
inferred from direct assay
(Maksimenko et al., 2015, Akbari et al., 2009)
located_in spindle microtubule
inferred from direct assay
(Plevock et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cp190 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 39 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cp190
Transgenic constructs containing regulatory region of Cp190
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die before end of P-stage
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage, with Scer\GAL4Act5C.PU
lethal - all die during P-stage (with Cp1901)
lethal - all die during P-stage (with Cp1902)
lethal - all die during P-stage (with Df(3R)P280-NR27)
lethal - all die during P-stage | recessive
lethal - all die during third instar larval stage | heat sensitive, with Scer\GAL4hs.PB
partially lethal - majority die (with Cp1903)
partially lethal - majority die (with Cp190En15)
partially lethal - majority die (with Cp190P1)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable (with Df(3R)E(mod)4-1P11)
Other Phenotypes
Allele
homeotic (with Cp1903)
homeotic (with Cp190En15)
homeotic (with Cp190P1)
majority die during pharate adult stage (with Cp1903)
majority die during pharate adult stage (with Cp190En15)
majority die during pharate adult stage (with Cp190P1)
some die during larval stage (with Cp1901)
some die during larval stage (with Cp1902)
some die during larval stage (with Df(3R)P280-NR27)
some die during larval stage | recessive
some die during P-stage | recessive
some die during pupal stage | recessive
Phenotype manifest in
Allele
abdominal segment 1 (with Cp1903)
abdominal segment 1 (with Cp190En15)
abdominal segment 1 (with Cp190P1)
abdominal segment 2 (with Cp1903)
abdominal segment 2 (with Cp190En15)
abdominal segment 2 (with Cp190P1)
abdominal sternite bristle (with Cp190En15)
abdominal sternite bristle (with Cp190P1)
abdominal tergite (with Cp1903)
abdominal tergite (with Cp190En15)
abdominal tergite (with Cp190P1)
centrosome
cleavage nucleus
embryonic/larval salivary gland | larval stage, with Scer\GAL4nub.PU
embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4hs.PB
eye, with Scer\GAL4dpp.blk1
eye, with Scer\GAL4ey.PU
larval neuroblast (with Df(3R)E(mod)4-1P11)
microtubule
mitotic spindle (with Df(3R)E(mod)4-1P11)
nucleus | larval stage, with Scer\GAL4nub.PU
pretarsus, with Scer\GAL4dpp.blk1
spindle pole centrosome (with Df(3R)E(mod)4-1P11)
tarsal segment, with Scer\GAL4dpp.blk1
wing (with Cp1903)
wing (with Cp190En15)
wing (with Cp190P1)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\DMP1
1 of 14
Yes
Yes
Hsap\HIC1
1 of 14
Yes
Yes
Hsap\IBSP
1 of 14
Yes
Yes
Hsap\IWS1
1 of 14
Yes
No
Hsap\KLHL21
1 of 14
Yes
No
Hsap\LEO1
1 of 14
Yes
No
Hsap\MUCL3
1 of 14
Yes
Yes
Hsap\RP1
1 of 14
Yes
No
Hsap\SAMD15
1 of 14
Yes
No
Hsap\TCHHL1
1 of 14
Yes
Yes
Hsap\ZBTB3
1 of 14
Yes
Yes
Hsap\ZBTB5
1 of 14
Yes
Yes
Hsap\ZBTB7A
1 of 14
Yes
No
1  
Hsap\ZBTB18
1 of 14
Yes
Yes
Hsap\ZBTB40
1 of 14
Yes
Yes
Hsap\ZBTB42
1 of 14
Yes
Yes
Hsap\ZBTB47
1 of 14
Yes
No
Hsap\ZNF652
1 of 14
Yes
Yes
Hsap\ZNF771
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Dmp1
1 of 14
Yes
Yes
Rnor\Hic1
1 of 14
Yes
Yes
Rnor\Ibsp
1 of 14
Yes
Yes
Rnor\Iws1
1 of 14
Yes
No
Rnor\Klhl21
1 of 14
Yes
No
Rnor\Leo1
1 of 14
Yes
No
Rnor\Rp1
1 of 14
Yes
No
Rnor\Zbtb3
1 of 14
Yes
Yes
Rnor\Zbtb5
1 of 14
Yes
Yes
Rnor\Zbtb18
1 of 14
Yes
Yes
Rnor\Zbtb21
1 of 14
Yes
Yes
Rnor\Zbtb40
1 of 14
Yes
Yes
Rnor\Zbtb42
1 of 14
Yes
Yes
Rnor\Zbtb47
1 of 14
Yes
No
Rnor\Zfp791
1 of 14
Yes
No
Mus musculus (laboratory mouse) (19)
Mmus\Dmp1
1 of 14
Yes
Yes
Mmus\Hic1
1 of 14
Yes
Yes
Mmus\Hic2
1 of 14
Yes
Yes
Mmus\Ibsp
1 of 14
Yes
Yes
Mmus\Iws1
1 of 14
Yes
No
Mmus\Klhl21
1 of 14
Yes
No
Mmus\Leo1
1 of 14
Yes
No
Mmus\Rp1
1 of 14
Yes
No
Mmus\Samd15
1 of 14
Yes
No
Mmus\Tchhl1
1 of 14
Yes
Yes
Mmus\Zbtb3
1 of 14
Yes
Yes
Mmus\Zbtb5
1 of 14
Yes
Yes
Mmus\Zbtb7a
1 of 14
Yes
Yes
Mmus\Zbtb9
1 of 14
Yes
Yes
Mmus\Zbtb18
1 of 14
Yes
Yes
Mmus\Zbtb40
1 of 14
Yes
Yes
Mmus\Zbtb42
1 of 14
Yes
Yes
Mmus\Zfp651
1 of 14
Yes
No
Mmus\Zfp791
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\ell3
1 of 13
Yes
No
Xtro\has3
1 of 13
Yes
Yes
Xtro\hic1
1 of 13
Yes
Yes
Xtro\zbtb3
1 of 13
Yes
Yes
Xtro\zbtb5
1 of 13
Yes
Yes
Xtro\zbtb7c
1 of 13
Yes
Yes
Xtro\zbtb18
1 of 13
Yes
Yes
Xtro\zbtb40
1 of 13
Yes
Yes
Xtro\zbtb47
1 of 13
Yes
Yes
Xtro\zbtb48
1 of 13
Yes
Yes
Xtro\znf281
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (19)
Drer\zbtb11
2 of 14
Yes
Yes
Drer\bcl6aa
1 of 14
No
No
Drer\gpatch3
1 of 14
No
Yes
Drer\hic1
1 of 14
No
Yes
Drer\hic2
1 of 14
No
Yes
Drer\iws1
1 of 14
No
No
Drer\leo1
1 of 14
No
No
Drer\LOC110437812
1 of 14
No
Yes
Drer\si:ch211-253b8.2
1 of 14
No
Yes
Drer\wu:fb44c10
1 of 14
No
No
Drer\zbtb3
1 of 14
No
Yes
Drer\zbtb7a
1 of 14
No
Yes
Drer\zbtb18
1 of 14
No
Yes
Drer\zbtb40
1 of 14
No
Yes
Drer\zbtb42
1 of 14
No
Yes
Drer\zbtb47b
1 of 14
No
Yes
Drer\znf281a
1 of 14
No
No
Drer\znf576.1
1 of 14
No
Yes
Drer\znf652
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\T24E12.10
1 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP001794
9 of 12
Yes
Yes
Agam\AgaP_AGAP000893
1 of 12
No
No
Agam\AgaP_AGAP001194
1 of 12
No
No
Agam\AgaP_AGAP002164
1 of 12
No
Yes
Agam\AgaP_AGAP002303
1 of 12
No
No
Agam\AgaP_AGAP005745
1 of 12
No
No
Agam\AgaP_AGAP005840
1 of 12
No
No
Agam\AgaP_AGAP007562
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\AT3G05900
1 of 13
Yes
Yes
Atha\AT3G56410
1 of 13
Yes
Yes
Atha\AT5G40450
1 of 13
Yes
Yes
Atha\G2484-1
1 of 13
Yes
Yes
Atha\SYD
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\AIP5
1 of 13
Yes
Yes
Scer\CHS5
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pic1
1 of 12
Yes
Yes
Spom\sec16
1 of 12
Yes
No
Spom\SPAC1A6.07
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cp190. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
Asph
1 of 13
CG1647
1 of 13
CG6118
1 of 13
CG9915
1 of 13
CG12391
1 of 13
CG12592
1 of 13
CG13185
1 of 13
CG34417
1 of 13
Dtg
1 of 13
Lmpt
1 of 13
M7BP
1 of 13
Muc18B
1 of 13
Su(var)2-HP2
1 of 13
tnc
1 of 13
zormin
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Cp190
    molecular sieving, molecular weight estimation by staining, comigration in non denaturing gel electrophoresis, two hybrid, anti bait coimmunoprecipitation, full identification by DNA sequencing, static light scattering, x-ray crystallography, cross-linking study
    (Bonchuk et al., 2024, Golovnin et al., 2023, Melnikova et al., 2023, Melnikova et al., 2019, Plevock et al., 2015, Matzat et al., 2013, Bonchuk et al., 2011)
    Cp190 - AGO2
    anti bait coimmunoprecipitation, western blot
    (Moshkovich et al., 2011)
    Cp190 - BEAF-32
    anti bait coimmunoprecipitation, western blot, electrophoretic mobility shift assay, autoradiography, pull down, Identification by mass spectrometry, two hybrid, peptide massfingerprinting, affinity chromatography technology
    (Kaushal et al., 2022, Lhoumaud et al., 2014, Liang et al., 2014, Vogelmann et al., 2014)
    Cp190 - CG1737
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - CG31365
    anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, pull down, two hybrid
    (Sabirov et al., 2021)
    Cp190 - CG4730
    pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, two hybrid
    (Sabirov et al., 2021)
    Cp190 - CG7099
    anti bait coimmunoprecipitation, western blot
    (Van Bortle et al., 2014)
    Cp190 - CTCF
    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, peptide massfingerprinting, pull down, molecular weight estimation by staining, anti tag western blot, two hybrid, Identification by mass spectrometry
    (Sokolov et al., 2024, Golovnin et al., 2023, Kaushal et al., 2022, Kaushal et al., 2021, Kyrchanova et al., 2021, Sabirov et al., 2021, Ong and Lin, 2018, Bonchuk et al., 2015, Maksimenko et al., 2015, Bohla et al., 2014, Cuartero et al., 2014, Ong et al., 2013, Moshkovich et al., 2011, Gerasimova et al., 2007, Mohan et al., 2007)
    Cp190 - Caf1-55
    anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
    (Bohla et al., 2014)
    Cp190 - Chro
    pull down, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kaushal et al., 2022, Maksimenko et al., 2015, Bohla et al., 2014, Vogelmann et al., 2014)
    Cp190 - Clamp
    anti bait coimmunoprecipitation, western blot
    (Bag et al., 2019)
    Cp190 - Csl4
    anti bait coimmunoprecipitation, western blot
    (Lim et al., 2013)
    Cp190 - Dp
    anti bait coimmunoprecipitation, western blot
    (Korenjak et al., 2014)
    Cp190 - Dredd
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Fukuyama et al., 2012)
    Cp190 - Dref
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - E(bx)
    anti bait coimmunoprecipitation, western blot
    (Chen et al., 2022, Kwon et al., 2016)
    Cp190 - E2f2
    anti bait coimmunoprecipitation, western blot
    (Korenjak et al., 2014)
    Cp190 - EcR
    anti bait coimmunoprecipitation, western blot, proximity-dependent biotin identification, Identification by mass spectrometry
    (Mazina et al., 2020)
    Cp190 - Gcn5
    anti bait coimmunoprecipitation, western blot
    (Ali et al., 2017)
    Cp190 - HIPP1
    pull down, Identification by mass spectrometry, two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
    (Kaushal et al., 2022, Melnikova et al., 2019, Alekseyenko et al., 2014)
    Cp190 - HP1b
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - HeT-A\gag
    pull down, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
    (Morgunova et al., 2021)
    Cp190 - Hmr
    anti bait coimmunoprecipitation, Identification by mass spectrometry
    (Lukacs et al., 2021)
    Cp190 - Hsap\CDK5
    enzymatic study, autoradiography
    (Ong and Lin, 2018)
    Cp190 - Ibf1
    anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, anti tag western blot, pull down, Identification by mass spectrometry
    (Kaushal et al., 2022, Maksimenko et al., 2015, Cuartero et al., 2014)
    Cp190 - Ibf2
    anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot, anti tag western blot
    (Kaushal et al., 2022, Maksimenko et al., 2015, Cuartero et al., 2014)
    Cp190 - Iswi
    anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
    (Bohla et al., 2014)
    Cp190 - M1BP
    anti bait coimmunoprecipitation, western blot, two hybrid, Identification by mass spectrometry, pull down, anti tag coimmunoprecipitation
    (Osadchiy et al., 2025, Golovnin et al., 2023, Kaushal et al., 2022, Bag et al., 2021)
    Cp190 - Map60
    two hybrid, anti bait coimmunoprecipitation, western blot, molecular weight estimation by staining, electrophoretic mobility shift assay, fluorescent dye label, pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, peptide massfingerprinting
    (Melnikova et al., 2023, Kaushal et al., 2022, Maksimenko et al., 2015, Cuartero et al., 2014, Kellogg et al., 1995, Raff et al., 1993, Kellogg and Alberts, 1992)
    Cp190 - Myb
    anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
    (Bohla et al., 2014)
    Cp190 - Nup98-96
    anti bait coimmunoprecipitation, western blot
    (Pascual-Garcia et al., 2017)
    Cp190 - Opbp
    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, two hybrid
    (Osadchiy et al., 2025, Golovnin et al., 2023, Zolotarev et al., 2017)
    Cp190 - Pen
    affinity chromatography technology, Identification by mass spectrometry
    (Virágh et al., 2012)
    Cp190 - Plp
    cosedimentation in solution, western blot
    (Gopalakrishnan et al., 2011)
    Cp190 - Rbf
    anti bait coimmunoprecipitation, western blot
    (Korenjak et al., 2014)
    Cp190 - Rm62
    anti bait coimmunoprecipitation, western blot, peptide massfingerprinting
    (Moshkovich et al., 2011, Lei and Corces, 2006)
    Cp190 - Rrp4
    anti bait coimmunoprecipitation, western blot
    (Lim et al., 2013)
    Cp190 - Rrp46
    anti bait coimmunoprecipitation, western blot
    (Lim et al., 2013)
    Cp190 - Rrp6
    anti bait coimmunoprecipitation, western blot
    (Lim et al., 2013)
    Cp190 - SA1
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - SMC1
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - SMC3
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - Sas-4
    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, pull down, peptide massfingerprinting
    (Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011)
    Cp190 - Ski6
    anti bait coimmunoprecipitation, western blot
    (Lim et al., 2013)
    Cp190 - Su(var)205
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - Topors
    anti bait coimmunoprecipitation, western blot
    (Capelson and Corces, 2005)
    Cp190 - Trl
    two hybrid
    (Bonchuk et al., 2024)
    Cp190 - ZIPIC
    anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, Identification by mass spectrometry, two hybrid, anti bait coimmunoprecipitation, western blot, anti tag western blot, molecular weight estimation by staining
    (Sokolov et al., 2024, Golovnin et al., 2023, Kaushal et al., 2022, Maksimenko et al., 2015)
    Cp190 - asl
    cosedimentation in solution, western blot
    (Gopalakrishnan et al., 2011)
    Cp190 - cliff
    two hybrid, anti bait coimmunoprecipitation, anti tag western blot
    (Sokolov et al., 2024)
    Cp190 - cnn
    cosedimentation in solution, western blot
    (Gopalakrishnan et al., 2011)
    Cp190 - east
    two hybrid, anti tag coimmunoprecipitation, anti tag western blot
    (Golovnin et al., 2015)
    Cp190 - fs(1)h
    pull down, western blot, anti bait coimmunoprecipitation
    (Kellner et al., 2013)
    Cp190 - gfzf
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - insv
    pull down, molecular weight estimation by staining, two hybrid, anti tag coimmunoprecipitation, western blot
    (Fedotova et al., 2019, Dai et al., 2015)
    Cp190 - l(3)mbt
    two hybrid
    (Melnikova et al., 2019)
    Cp190 - mip120
    anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
    (Bohla et al., 2014)
    Cp190 - mip130
    anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, western blot
    (Bohla et al., 2014, Korenjak et al., 2014)
    Cp190 - mod(mdg4)
    anti bait coimmunoprecipitation, western blot, two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, Identification by mass spectrometry
    (Melnikova et al., 2023, Chen et al., 2022, Kaushal et al., 2022, Bag et al., 2021, Melnikova et al., 2019, Melnikova et al., 2019, Melnikova et al., 2017, Golovnin et al., 2016, Maksimenko et al., 2015, Cuartero et al., 2014, Lim et al., 2013, Golovnin et al., 2012, Moshkovich et al., 2011, Oliver et al., 2010, Gerasimova et al., 2007, Lei and Corces, 2006, Pai et al., 2004)
    Cp190 - nom
    two hybrid
    (Pekina et al., 2023)
    Cp190 - not
    anti tag coimmunoprecipitation, molecular sieving, Identification by mass spectrometry, two hybrid, pull down, western blot, anti bait coimmunoprecipitation
    (Erez et al., 2021)
    Cp190 - pita
    anti bait coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, Identification by mass spectrometry, two hybrid, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
    (Golovnin et al., 2023, Kaushal et al., 2022, Sabirov et al., 2021, Sabirov et al., 2021, Maksimenko et al., 2015, Cuartero et al., 2014)
    Cp190 - piwi
    anti bait coimmunoprecipitation, western blot
    (Moshkovich et al., 2011)
    Cp190 - prod
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - pzg
    anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, pull down, Identification by mass spectrometry
    (Kaushal et al., 2022, Maksimenko et al., 2015, Bohla et al., 2014)
    Cp190 - rib
    two hybrid
    (Bonchuk et al., 2024)
    Cp190 - rump
    anti bait coimmunoprecipitation, western blot
    (King et al., 2014)
    Cp190 - shep
    anti bait coimmunoprecipitation, western blot
    (Matzat et al., 2012)
    Cp190 - su(Hw)
    anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, pull down, Identification by mass spectrometry, peptide massfingerprinting, two hybrid, anti tag western blot, full identification by DNA sequencing, experimental knowledge based, molecular weight estimation by staining, electrophoretic mobility shift assay, autoradiography, primer specific pcr, fluorescent dye label
    (Melnikova et al., 2024, Golovnin et al., 2023, Melnikova et al., 2023, Chen et al., 2022, Kaushal et al., 2022, Bag et al., 2021, Sabirov et al., 2021, Bag et al., 2019, Melnikova et al., 2019, Melnikova et al., 2018, Melnikova et al., 2018, Melnikova et al., 2017, Golovnin et al., 2016, Maksimenko et al., 2015, Cuartero et al., 2014, Rhee et al., 2014, Matzat et al., 2013, Soshnev et al., 2012, Moshkovich et al., 2011, Gerasimova et al., 2007, Lei and Corces, 2006, Pai et al., 2004)
    Cp190 - vtd
    pull down, Identification by mass spectrometry
    (Kaushal et al., 2022)
    Cp190 - γTub23C
    anti bait coimmunoprecipitation, western blot
    (Raff et al., 1993)
    Cp190 - γTub37C
    anti bait coimmunoprecipitation, western blot
    (Raff et al., 1993)
    RNA-protein
    Physical Interaction
    Assay
    References
    Cp190
    molecular sieving, molecular weight estimation by staining, comigration in non denaturing gel electrophoresis, two hybrid, anti bait coimmunoprecipitation, full identification by DNA sequencing, static light scattering, x-ray crystallography, cross-linking study
    (Bonchuk et al., 2024, Golovnin et al., 2023, Melnikova et al., 2023, Melnikova et al., 2019, Plevock et al., 2015, Matzat et al., 2013, Bonchuk et al., 2011)
    Cp190 - CG10555
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - CG43338
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - Msh6
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - brm
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - dbr
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - ems
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - mute
    anti bait coimmunoprecipitation, full identification by DNA sequencing
    (Matzat et al., 2013)
    Cp190 - su(Hw)
    anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, pull down, Identification by mass spectrometry, peptide massfingerprinting, two hybrid, anti tag western blot, full identification by DNA sequencing, experimental knowledge based, molecular weight estimation by staining, electrophoretic mobility shift assay, autoradiography, primer specific pcr, fluorescent dye label
    (Melnikova et al., 2024, Golovnin et al., 2023, Melnikova et al., 2023, Chen et al., 2022, Kaushal et al., 2022, Bag et al., 2021, Sabirov et al., 2021, Bag et al., 2019, Melnikova et al., 2019, Melnikova et al., 2018, Melnikova et al., 2018, Melnikova et al., 2017, Golovnin et al., 2016, Maksimenko et al., 2015, Cuartero et al., 2014, Rhee et al., 2014, Matzat et al., 2013, Soshnev et al., 2012, Moshkovich et al., 2011, Gerasimova et al., 2007, Lei and Corces, 2006, Pai et al., 2004)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Cp190
    suppressible
    Map60
    (Butcher et al., 2004)
    Cp190
    suppressible
    sqh
    (Chodagam et al., 2005)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ct
    suppressible
    Cp190
    (Oliver et al., 2010)
    ct|mod(mdg4)
    suppressible
    Cp190
    (Oliver et al., 2010)
    mod(mdg4)|ct
    enhanceable
    Cp190
    (Matzat et al., 2013)
    y
    suppressible
    Cp190
    (Oliver et al., 2010)
    y|mod(mdg4)
    suppressible
    Cp190
    (Oliver et al., 2010)
    External Data
    Subunit Structure (UniProtKB)
    Homodimerizes via the N-terminal BTB domain (PubMed:26649574). Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:15574329). Interacts with Cp60 (PubMed:8491775, PubMed:8590797, PubMed:9700165). Interacts with inv (PubMed:25561495). Interacts with Nup98 (PubMed:28366641). Interacts (via BTB domain) with pita (via region between the ZAD domain and the first zinc finger domain); the interaction is direct (PubMed:25342723, PubMed:33752739). Interacts with ZIPIC (via region between the ZAD domain and the first zinc finger domain); the interaction is direct (PubMed:25342723). Interacts (via regions between the BTB domain and first zinc finger domain) with cliff (via regions flanking MADF domain 1); the interaction is probably direct (PubMed:38769058). Associates (via N-terminus) with microtubules; the interaction is direct, is enhanced by dimerization and involves multiple regions within the N-terminus (PubMed:14996941, PubMed:26649574, PubMed:8491775, PubMed:8522588). Microtubule association is enriched at growing plus ends (PubMed:26649574).
    (UniProt, Q24478 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-56
    Cytogenetic map
    88E9-88E11
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    88E9-88E11
    Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-56

    (FlyBase, 2016)

    3-55.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (24)
    cDNA Clones (97)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          DNA-protein interactions: genome-wide binding profile assayed for Cp190 protein in 0-12 hr embryos; see Insulator_Class_I.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245).

          (Nègre et al., 2010)

          Cp190 proteins can be modified by smt3.

          (Capelson and Corces, 2006)

          Map60

          (Butcher et al., 2004)

          The introduction of dsRNA made from templates generated with primers directed against this gene into S2 cells prevents the accumulation of Map60 to mitotic centrosomes.

          (Butcher et al., 2004)

          Cp190 plays an essential role in flies that is independent of its association with centrosomes or microtubules.

          (Butcher et al., 2004)

          Cp190 mutations act as recessive suppressors of gypsy-induced phenotypes, suggesting that Cp190 is an essential component of the gypsy insulator.

          (Pai et al., 2004)

          Cp190 requires su(Hw) in order to bind to the insulator present in the gypsy retrotransposon, but su(Hw) is not necessary for the interaction of Cp190 with endogenous insulator sites.

          (Pai et al., 2004)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Fluorescently labelled bacterially expressed Cp190 is injected into living embryos and protein behaviour during the rapid syncytial blastoderm divisions (nuclear cycles 10-13) is followed.

          (Oegema et al., 1997)

          The localisation of Cp190 protein within the fertilised egg has been studied.

          (Riparbelli et al., 1997)

          The region between amino acids 385 and 508 of the Cp190 protein is sufficient for good centrosomal localisation. A nuclear localisation domain is located between amino acids 201 and 271.

          (Oegema et al., 1995)

          Cp190 is associated with the centrosome during mitosis and during interphase the protein is associated with a large number of specific chromosomal sites. Cp190 binds to chromatin in association with another centrosomal protein, Map60.

          (Whitfield et al., 1995)

          By using monoclonal antibodies that recognize protein components of the mitotic apparatus to screen expression libraries, Cen185, which encodes a protein associated with the centrosome, was cloned.

          (Whitfield et al., 1988)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: Cen190 CG6384

          (Zheng, 1999.11)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (31)
          Reported As
          Symbol Synonym
          AbS1-4
          Bx-63
          (Semeshin et al., 2002)
          Bx63
          (Sunkel et al., 1995, Foe et al., 1993)
          CEN190
          (Izumi et al., 2004)
          CG6384
          (Lomaev et al., 2017, Neuert et al., 2017, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Talamillo et al., 2008, Goldstein and Gunawardena, 2000)
          CP-190
          (Gopalakrishnan et al., 2011, Schaefer et al., 2008, Stevenson et al., 2001, Helps et al., 1998, Matthies et al., 1996)
          CP-60
          (Vidwans and O'Farrell, 1999)
          CP190
          (Osadchiy et al., 2025, Bonchuk et al., 2024, Kamalyan et al., 2024, Tullius et al., 2024, Zhang et al., 2024, Erokhin et al., 2023, Golovnin et al., 2023, Krasnov et al., 2023, Kyrchanova et al., 2023, Melnikova and Golovnin, 2023, Messina et al., 2023, Pekina et al., 2023, Bag et al., 2022, Batut et al., 2022, Hannaford et al., 2022, Richards et al., 2022, Torres-Campana et al., 2022, Bag et al., 2021, Chetverina et al., 2021, Erez et al., 2021, Kalashnikova et al., 2021, Khalisova et al., 2021, Kyrchanova et al., 2021, Sabirov et al., 2021, Arzate-Mejía et al., 2020, De et al., 2020, Dong et al., 2020, Fresán et al., 2020, Heurteau et al., 2020, Maksimenko et al., 2020, Mazina et al., 2020, Melnikova et al., 2020, Meyer-Nava et al., 2020, Rozenwald et al., 2020, Santana et al., 2020, Bag et al., 2019, Blake-Hedges and Megraw, 2019, Cheutin and Cavalli, 2019, Fedotova et al., 2019, Glenn and Geyer, 2019, Melnikova et al., 2019, Melnikova et al., 2019, Pal et al., 2019, Ueberschär et al., 2019, Ando-Kuri et al., 2018, Lu et al., 2018, Melnikova et al., 2018, Melnikova et al., 2018, Mourad and Cuvier, 2018, Ong and Lin, 2018, Pokholkova et al., 2018, Wang et al., 2018, Ali et al., 2017, El-Sharnouby et al., 2017, Gerland et al., 2017, Heseding et al., 2017, Lattao et al., 2017, Lomaev et al., 2017, Melnikova et al., 2017, Mourad et al., 2017, Rowley et al., 2017, Zolotarev et al., 2017, Golovnin et al., 2016, Khoroshko et al., 2016, Zielke et al., 2016, Bonchuk et al., 2015, Dai et al., 2015, Golovnin et al., 2015, Li et al., 2015, Magbanua et al., 2015, Maksimenko et al., 2015, Plevock et al., 2015, Saberi et al., 2015, Singh and Mishra, 2015, Wolle et al., 2015, Ahanger et al., 2014, Alekseyenko et al., 2014, Bowman et al., 2014, Cuartero et al., 2014, Ho et al., 2014, Korenjak et al., 2014, Kyrchanova and Georgiev, 2014, Lhoumaud et al., 2014, Matzat and Lei, 2014, McElroy et al., 2014, Pascual-Garcia et al., 2014, Pathak et al., 2014, Van Bortle et al., 2014, Vogelmann et al., 2014, Zielke and Saumweber, 2014, Kellner et al., 2013, Kyrchanova et al., 2013, Li and Zhou, 2013, Li et al., 2013, Matzat et al., 2013, Ong et al., 2013, Rohrbaugh et al., 2013, Rubin and Green, 2013, Schoborg et al., 2013, Schuettengruber and Cavalli, 2013, Soshnev et al., 2013, Feller et al., 2012, Follmer et al., 2012, Golovnin et al., 2012, Gopalakrishnan et al., 2012, Gurudatta et al., 2012, Hou et al., 2012, Matzat et al., 2012, Philip et al., 2012, Sakoparnig et al., 2012, Schwartz et al., 2012, Smith et al., 2012, Soshnev et al., 2012, Van Bortle et al., 2012, Virágh et al., 2012, Bonchuk et al., 2011, Demakov et al., 2011, Erokhin et al., 2011, Li et al., 2011, Ma and Jarman, 2011, Nègre et al., 2011, Rach et al., 2011, Ramos et al., 2011, Richter et al., 2011, Sultana et al., 2011, Vatolina et al., 2011, Vatolina et al., 2011, Wood et al., 2011, Erokhin et al., 2010, Guertin and Lis, 2010, Kalverda and Fornerod, 2010, Martins et al., 2010, modENCODE Consortium et al., 2010, Nègre et al., 2010, Schoborg and Labrador, 2010, van Bemmel et al., 2010, Wallace et al., 2010, Akbari et al., 2009, Bushey et al., 2009, Meireles et al., 2009, Schaaf et al., 2009, Akbari et al., 2008, Ducat et al., 2008, Georgiev et al., 2008, Lei et al., 2008, Mottier et al., 2008, Oliver, 2008, Pérez-Lluch et al., 2008, Rogers et al., 2008, Akbari et al., 2007, Basto et al., 2007, Gerasimova et al., 2007, Golovnin et al., 2007, Lei, 2007, Mohan et al., 2007, Rodrigues-Martins et al., 2007, Basto et al., 2006, Capelson and Corces, 2006, Lei and Corces, 2006, Barros et al., 2005, Bettencourt-Dias et al., 2005, Capelson and Corces, 2005, Cullen et al., 2005, Prigent et al., 2005, Riparbelli and Callaini, 2005, McHugh et al., 2004, Pai et al., 2004, Raynaud-Messina et al., 2004, Blagden and Glover, 2003, Deak et al., 2003, Marshall, 2003, Riparbelli and Callaini, 2003, Staeva-Vieira et al., 2003, Terada et al., 2003, Fung et al., 2002, Kaltschmidt and Brand, 2002, Begun, 2001, Debec et al., 2001, Donaldson et al., 2001, Loppin et al., 2001, Nickerson, 2001, Barbosa et al., 2000, Begun and Whitley, 2000, Brent et al., 2000, Goldstein and Gunawardena, 2000, Kaltschmidt et al., 2000, Lemos et al., 2000, Sisson et al., 2000, Yucel et al., 2000, Avides and Glover, 1999, Callaini et al., 1999, Cullen et al., 1999, Debec et al., 1999, Johansen et al., 1999, Llamazares et al., 1999, Megraw et al., 1999, Robinson et al., 1999, Vaizel-Ohayon and Schejter, 1999, Adams et al., 1998, Glover et al., 1998, Gonzalez et al., 1998, Gonzalez et al., 1998, Kodjabachian et al., 1998, Moritz et al., 1998, Oegema, 1998, Riparbelli and Callaini, 1998, Wilson and Borisy, 1998, Callaini et al., 1997, Oegema et al., 1997, Ohkura et al., 1997, Philp and Glover, 1997, Reed and Orr-Weaver, 1997, Riparbelli et al., 1997, Sibon et al., 1997, Frenz and Glover, 1996, Riparbelli and Callaini, 1996, Sibon and Theurkauf, 1996, Kellogg et al., 1995, Moritz et al., 1995, Oegema et al., 1995, Whitfield, 1995.7.6, Whitfield et al., 1995)
          CP190_DROME
          (Fukuyama et al., 2012)
          Cen185
          (Whitfield et al., 1988)
          Cen190
          (Bauer-DuMont et al., 2004, Zraly et al., 2002, Li and Kaufman, 1996, Glover et al., 1995, Cambiazo et al., 1993)
          Cp190
          (Tam and Harris, 2024, Kahn et al., 2023, Melnikova et al., 2023, Yheskel et al., 2023, Amankwaa et al., 2022, Kaushal et al., 2022, Simmons et al., 2022, Kaushal et al., 2021, Peterson et al., 2021, Sabirov et al., 2021, Wolfe et al., 2021, Kyrchanova et al., 2020, Omura and Lott, 2020, Bag et al., 2019, Cardozo Gizzi et al., 2019, Chen and Lei, 2019, Gao et al., 2019, Luzhin et al., 2019, Matthews and White, 2019, Meltzer et al., 2019, Viets et al., 2019, Rennie et al., 2018, Tsui et al., 2018, Ciabrelli et al., 2017, Melnikova et al., 2017, Neuert et al., 2017, Pascual-Garcia et al., 2017, Schwartz and Cavalli, 2017, Transgenic RNAi Project members, 2017-, Kwon et al., 2016, Savitsky et al., 2016, Ulianov et al., 2016, Comoglio and Paro, 2014, Jiang and Singh, 2014, Rhee et al., 2014, Gurudatta et al., 2013, Matzat et al., 2013, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Maeng et al., 2012, Stefanov et al., 2012, Baxley et al., 2011, Erokhin et al., 2011, Friedman et al., 2011, Toku et al., 2011, Oliver et al., 2010, Bartkuhn et al., 2009, Fisher et al., 2008, Kwong et al., 2008, Bakal et al., 2007, Buszczak et al., 2007, Pai et al., 2004)
          DMAP 190
          (Kellogg and Alberts, 1992)
          DMAP-190
          (Moritz and Alberts, 1992)
          DMAP190
          (McKim and Hawley, 1995, Oegema et al., 1994, Wilson and Fuller, 1994, Oegema et al., 1993, Kellogg and Alberts, 1992, Postner et al., 1992)
          Dmap190
          (Endow et al., 1994)
          E(mod)4-1
          (Pai et al., 2004)
          Map190
          Rb188
          (Ceron et al., 2001, Inoue et al., 2000, Audibert and Simonelig, 1999, Mathe et al., 1998, Callaini et al., 1994, Callaini and Riparbelli, 1992, Riparbelli and Callaini, 1992, Yasuda et al., 1991)
          cp190
          (Vicars et al., 2021, Erokhin et al., 2010)
          dmap190
          (Craig and Brink, 1996)
          Name Synonyms
          Centrosomal Protein 190
          (Rohrbaugh et al., 2013, Oliver et al., 2010, Pai et al., 2004)
          Centrosomal Protein 190 kD
          (Rhee et al., 2014, Soshnev et al., 2013)
          Centrosomal Protein 90
          (Bushey et al., 2009)
          Centrosomal Protein of 190 kDa
          (Soshnev et al., 2012)
          Centrosomal protein 190
          (Magbanua et al., 2015, Matzat et al., 2013)
          Centrosomal protein 190 kDa
          (Nègre et al., 2011, Talamillo et al., 2008)
          Centrosomal protein 190kD
          (Ducat et al., 2008)
          Centrosomal protein of 190 kDa
          (Comoglio and Paro, 2014)
          E(mod)4-1
          (Pai et al., 2004)
          Enhancer of mod(mdg4)4-1
          (Pai et al., 2004)
          centrosomal protein 190
          (Wood et al., 2011)
          Secondary FlyBase IDs
          • FBgn0014463
          Datasets (4)
          Study focus (4)
          Experimental Role
          Project
          Project Type
          Title
          • RNAi_target
          modENCODE_chromatin_proteins_cells
          Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
          • bait_protein
          modENCODE_chromatin_proteins_flies
          Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
          • RNAi_target
          modENCODE_chromatin_histones_cells
          Genome-wide localization of histones and their modifications in cell lines by ChIP-chip and ChIP-Seq.
          • bait_protein
          modENCODE_regulation_insulators
          Genome-wide localization of insulator proteins by ChIP-chip and ChIP-Seq.
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 46 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          References (398)