A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Cp190

General Information
SymbolDmel\Cp190SpeciesD. melanogaster
NameCentrosomal protein 190kDAnnotation symbolCG6384
Feature typeprotein_coding_geneFlyBase IDFBgn0000283
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map88E9-88E11Sequence location3R:11,096,146..11,100,927 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Centrosomal protein 190kD is referred to in FlyBase by the symbol Cp190 (CG6384, FBgn0000283). It has the cytological map location 88E9-88E11. Its sequence location is 3R:11096146..11100927. Its molecular function is described as: microtubule binding; zinc ion binding. It is involved in the biological processes: microtubule-based process; nuclear axial expansion. 31 alleles are reported. The phenotypes of these alleles are annotated with: cleavage nucleus; centrosome; microtubule. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
88E9-88E11  
Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Cp190 for information on other features
detailed view FBtr0083128 FBtr0110811 FBtr0290018 FBtr0083127 FBtr0083126 FBtr0083066 FBtr0083125 FBpp0288457 FBpp0082581 FBpp0082580 FBpp0082525 FBpp0082579 FBti0043507 FBti0058108 FBti0050698 FBti0040200 FBti0076413 FBti0029400 FBti0100067 FBti0043233 FBti0067392 FBti0039418 FBti0047550
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0083126
  4086
  1096
FBtr0083127
  4184
  1096
Additional Transcript Data & Comments
Reported size (kB)
4.0 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0082580  
121.7  
1096  
4.29  
FBpp0082581  
121.7  
1096  
4.29  
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
BTB/POZ-like (IPR000210)
BTB/POZ (IPR013069)
BTB/POZ fold (IPR011333)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     adult stage | female
     embryonic stage | 0-16 hr
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
       embryonic stage | blastoderm
      Marker for
        Subcellular Localization
        CV Term
        nucleus centrosome
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 7 )
        For All Classical Alleles Show

        Allele of Cp190ClassMutagenStocksKnown lesion
        Cp1901loss of function0 --
        Cp1902loss of function0 --
        Cp190CB049330 Yes
        Cp190EY209971 --
        Cp190H31-20 Yes
        Cp190H4-1hypomorph0 Yes
        Cp190H53-20 Yes
        hide Alleles Carried on Transgenic Constructs ( 24 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Cp190ClassMutagenStocksKnown lesion
        Cp190167-1090.T:Zzzz\His60 Yes
        Cp190167-2710 Yes
        Cp190167-3210 Yes
        Cp190167-4680 Yes
        Cp190167-6080 Yes
        Cp190207-3210 Yes
        Cp190207-6080 Yes
        Cp190240-3210 Yes
        Cp190240-6080 Yes
        Cp190266-6080 Yes
        Cp190309-4270 Yes
        Cp190309-4560 Yes
        Cp190309-6080 Yes
        Cp190385-5080 Yes
        Cp190421-6080 Yes
        Cp190428-6080 Yes
        Cp190451-6080 Yes
        Cp190504-7890 Yes
        Cp190646-9370 Yes
        Cp190784-10900 Yes
        Cp190GD119082 Yes
        Cp190Ubi-p63E.PB0 Yes
        Cp190Δ1750 Yes
        Cp190ΔM.Ubi-p63E0 Yes
        hide Aneuploid Aberrations
        Useful duplication
        Disrupted in
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        characterization construct
        Insertions
        Type of insertions
        Name
        Expression data
        miscellaneous insertions
        insertion of mobile activating element
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        Cp190 mutations act as recessive suppressors of gypsy-induced phenotypes, suggesting that Cp190 is an essential component of the gypsy insulator.
        By using monoclonal antibodies that recognize protein components of the mitotic apparatus to screen expression libraries, Cen185, which encodes a protein associated with the centrosome, was cloned.
        Cp190 is associated with the centrosome during mitosis and during interphase the protein is associated with a large number of specific chromosomal sites. Cp190 binds to chromatin in association with another centrosomal protein, Map60.
        The region between amino acids 385 and 508 of the Cp190 protein is sufficient for good centrosomal localisation. A nuclear localisation domain is located between amino acids 201 and 271.
        hide Gene Ontology: Function, Process & Cellular Component ( 8 )
        hide Molecular Function
        CV term
        References
        inferred from sequence or structural similarity
        inferred from direct assay
        inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880
        hide Biological Process
        CV term
        References
        inferred from sequence or structural similarity
        inferred from mutant phenotype
        hide Cellular Component
        CV term
        References
        inferred from direct assay
        non-traceable author statement
        inferred from direct assay
        inferred from direct assay
        inferred from direct assay
        inferred from electronic annotation with InterPro:IPR000886
        inferred from sequence or structural similarity
        inferred from direct assay
        hide Sequence Ontology: Class of Gene
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Cp190 allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        Drosophila PIMRider - The Drosophila Protein Interaction map
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 3 )
        VDRC
        Bloomington
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 56 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones