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Gene Dmel\Cp190

General Information
Symbol	Dmel\Cp190	Species	D. melanogaster
Name	Centrosomal protein 190kD	Annotation symbol	CG6384
Feature type	protein_coding_gene	FlyBase ID	FBgn0000283
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Rb188, dmap190, CEN190, CP-190, Bx63
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88E9-88E11	Sequence location	3R:11,096,146..11,100,927 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Centrosomal protein 190kD is referred to in FlyBase by the symbol Dmel\Cp190 (CG6384, FBgn0000283). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: microtubule binding; chromatin insulator sequence binding. There is experimental evidence that it is involved in the biological process: nuclear axial expansion. 35 alleles are reported. The phenotypes of these alleles are annotated with: centrosome; microtubule; cleavage nucleus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631940_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Cp190. Gene sequence location is 3R:11096146..11100927.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 Wallace et al., 2010, Chromosoma 119(2): 177--194 Erokhin et al., 2010, Chromosoma 119(3): 243--253 Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Guertin and Lis, 2010, PLoS Genet. 6(9): Sequence features BKN24349 HFA16607
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88E9-88E11   Limits computationally determined from genome sequence between P{lacW}Hsc70-4L3929 and P{lacW}MRG15j6A3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cp190 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cp190-RA FBtr0083126  NM_079635   4086   1096 Cp190-RB FBtr0083127  NM_169632   4184   1096
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Whitfield et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cp190-PA   FBpp0082580   121.7   1096   4.29     NP_524359   AAF55159 Cp190-PB   FBpp0082581   121.7   1096   4.29     NP_731998   AAN13643
Additional Polypeptide Data & Comments
Reported size (kDa)	185 (kD) (Whitfield et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201553   AA201898   AA202220   AA202620   AA263327   AA390436   AA390543   AA392344   AA439310   AA440189   AA440701   AA567674   AA695050   AA735482   AA816931   AA817460   AA820938   AA942454   AA942461   AA948851   AA949342   AA950047   AA951062   AE014297 AAF55159   AE014297 AAN13643   AI456879   AI456997   AI457075   AI511687   AI511693   AI515569   AI515602   AI518148   AI531076   AI531180   AI532177   AI532674   AI533381   AI533383   AI541906   AI543869   AI546252   AI546487   AW941502   BG636326   BI164646   BI165847   BI353370   BI358341   BI367338   BI369885   BI371155   BI373641   BI485527   BI579101   BT010090 AAQ22559   CO154999   CO179511   CO189438   CO286656   CO293207   CO298517   CO318462   CO319369   CO320015   DN153949   EC057343   EC065398   EC067496   EC084780   EC216218   EC218152   EC218826   EC220081   EC225743   EC227516   EC233510   EC250137   EC261119   EC261969   EV583913   EV584784   EV587569   EV596950   EV599208   GH756002   GH761159   GH822469   GH827946   GH828616   GH834955   GH840246   GH875393   GH902484   GH902979   GH904902   GH915451   GH925509   GH930564   GH930997   GH931995   GH938341   Z50021 CAA90324
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24478
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (Whitfield et al., 1988) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 16     (Whitfield et al., 1988) Comment:reference states 0-16 hr AEL
Additional Descriptive Data
	Cp190 transcripts are detected throughout development with the highest levels in 0-16 hr embryos and adult females. (Whitfield et al., 1988)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference blastoderm stage     (Whitfield et al., 1988)
Additional Descriptive Data
	Cp190 protein is found in centrosomes of mitotically active nuclei. (Whitfield et al., 1988)
Marker for
Subcellular Localization
CV Term	nucleus centrosome (Whitfield et al., 1988)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000283    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000283 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000283 expression level Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr    14990 embryo 04-06hr    12096 embryo 06-08hr    11281 embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8354) embryo 02-04hr  (14990) embryo 04-06hr  (12096) embryo 06-08hr  (11281) embryo 08-10hr  (9337) embryo 10-12hr  (4294) embryo 12-14hr  (5133) embryo 14-16hr  (3815) embryo 16-18hr  (3357) embryo 18-20hr  (2039) embryo 20-22hr  (4454) embryo 22-24hr  (4003) larva L1  (1456) larva L2  (1537) larva L3 12hr old  (1213) larva L3 puffstage 1-2  (1309) larva L3 puffstage 3-6  (2236) larva L3 puffstage 7-9  (2579) white prepupae new  (2724) white prepupae 12hr  (2579) white prepupae 24hr  (3423) pupae 2d postWPP  (1929) pupae 3d postWPP  (1149) pupae 4d postWPP  (997) adult male 01day  (1066) adult male 05day  (1183) adult male 30day  (1169) adult female 01day  (2835) adult female 05day  (5502) adult female 30day  (5545) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8354) embryo 02-04hr  (14990) embryo 04-06hr  (12096) embryo 06-08hr  (11281) embryo 08-10hr  (9337) embryo 10-12hr  (4294) embryo 12-14hr  (5133) embryo 14-16hr  (3815) embryo 16-18hr  (3357) embryo 18-20hr  (2039) embryo 20-22hr  (4454) embryo 22-24hr  (4003) larva L1  1456 larva L2  (1537) larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6  (2236) larva L3 puffstage 7-9  (2579) white prepupae new  (2724) white prepupae 12hr  (2579) white prepupae 24hr  (3423) pupae 2d postWPP  (1929) pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day  (2835) adult female 05day  (5502) adult female 30day  (5545) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr  (14990) embryo 04-06hr  (12096) embryo 06-08hr  (11281) embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr    14990 embryo 04-06hr    12096 embryo 06-08hr    11281 embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000283 expression level Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr    14990 embryo 04-06hr    12096 embryo 06-08hr    11281 embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8354) embryo 02-04hr  (14990) embryo 04-06hr  (12096) embryo 06-08hr  (11281) embryo 08-10hr  (9337) embryo 10-12hr  (4294) embryo 12-14hr  (5133) embryo 14-16hr  (3815) embryo 16-18hr  (3357) embryo 18-20hr  (2039) embryo 20-22hr  (4454) embryo 22-24hr  (4003) larva L1  (1456) larva L2  (1537) larva L3 12hr old  (1213) larva L3 puffstage 1-2  (1309) larva L3 puffstage 3-6  (2236) larva L3 puffstage 7-9  (2579) white prepupae new  (2724) white prepupae 12hr  (2579) white prepupae 24hr  (3423) pupae 2d postWPP  (1929) pupae 3d postWPP  (1149) pupae 4d postWPP  (997) adult male 01day  (1066) adult male 05day  (1183) adult male 30day  (1169) adult female 01day  (2835) adult female 05day  (5502) adult female 30day  (5545) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8354) embryo 02-04hr  (14990) embryo 04-06hr  (12096) embryo 06-08hr  (11281) embryo 08-10hr  (9337) embryo 10-12hr  (4294) embryo 12-14hr  (5133) embryo 14-16hr  (3815) embryo 16-18hr  (3357) embryo 18-20hr  2039 embryo 20-22hr  (4454) embryo 22-24hr  (4003) larva L1  1456 larva L2  1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6  2236 larva L3 puffstage 7-9  (2579) white prepupae new  (2724) white prepupae 12hr  (2579) white prepupae 24hr  (3423) pupae 2d postWPP  1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day  (2835) adult female 05day  (5502) adult female 30day  (5545) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr  14990 embryo 04-06hr  12096 embryo 06-08hr  11281 embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8354 embryo 02-04hr    14990 embryo 04-06hr    12096 embryo 06-08hr    11281 embryo 08-10hr    9337 embryo 10-12hr    4294 embryo 12-14hr    5133 embryo 14-16hr    3815 embryo 16-18hr    3357 embryo 18-20hr    2039 embryo 20-22hr    4454 embryo 22-24hr    4003 larva L1    1456 larva L2    1537 larva L3 12hr old    1213 larva L3 puffstage 1-2    1309 larva L3 puffstage 3-6    2236 larva L3 puffstage 7-9    2579 white prepupae new    2724 white prepupae 12hr    2579 white prepupae 24hr    3423 pupae 2d postWPP    1929 pupae 3d postWPP    1149 pupae 4d postWPP    997 adult male 01day    1066 adult male 05day    1183 adult male 30day    1169 adult female 01day    2835 adult female 05day    5502 adult female 30day    5545 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000283    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000283 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000283 expression level Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (803.275) Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland  (573.6) Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain  (558.1) Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary  (999.1) Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000283 expression level Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland  573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain  558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary  (999.1) Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    803.275 Larval Midgut    185.9 Larval Hindgut    234.1 Larval Malpighian Tubules    227.8 Larval Fat Body    225.2 Larval Salivary Gland    573.6 Larval Trachea    494.575 Larval Carcass    284.175 Adult Head    255.1 Adult Eye    276.125 Adult Brain    558.1 Adult Thoracic-Abdominal Ganglion    327 Adult Crop    295.8 Adult Midgut    215 Adult Hindgut    230.5 Adult Malpighian Tubules    382.8 Adult Fat Body    193.9 Adult Salivary Gland    366 Adult Heart    236.475 Adult VirginFemale Spermatheca    226.7 Adult InseminatedFemale Spermatheca    246.4 Adult Ovary    999.1 Adult Testis    80.8 Adult Male Accessory Gland    231 Adult Carcass    204.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    255.1   NA  Eye    276.125   NA  Brain    558.1   803.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    327   NA  Crop    295.8   185.9  Midgut    215   234.1  Hindgut    230.5   227.8  Malpighian Tubules    382.8   225.2  Fat Body    193.9   573.6  Salivary Gland    366   NA  Heart    236.475   494.575  Trachea    NA   NA  VirginFemale Spermatheca    226.7   NA  InseminatedFemale Spermatheca    246.4   NA  Ovary    999.1   NA  Testis    80.8   NA  Male Accessory Gland    231   284.175  Carcass    204.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6384-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Cp190H31-2 Cp190H53-2 lethal | larval stage | partially (with Cp1901) Cp1902 lethal | larval stage | partially (with Cp1902) Cp1901 lethal | larval stage | partially (with Df(3R)P280-NR27) Cp1901 Cp1902 lethal | larval stage | partially | recessive Cp1901 Cp1902 lethal | partially | pupal stage | recessive Cp190Ubi-p63E.PB lethal | pharate adult stage (with Cp1901) Cp1902 lethal | pharate adult stage (with Cp1902) Cp1901 lethal | pharate adult stage (with Df(3R)P280-NR27) Cp1901 Cp1902 lethal | pharate adult stage | recessive Cp1901 Cp1902 lethal | pupal stage | recessive Cp190ΔM.Ubi-p63E viable Cp190CB04933 Cp190H4-1 viable, with Scer\GAL4pnr-MD237 Cp190GD11908 Phenotype manifest in Allele centrosome Cp190ΔM.Ubi-p63E cleavage nucleus Cp1902 microtubule Cp190ΔM.Ubi-p63E
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Cp190 Class Mutagen Stocks Known lesion Cp190EY20997 P-element activity 1 -- Cp190G5211 P-element activity 1 -- Cp1901 loss of function allele ethyl methanesulfonate 0 -- Cp1902 loss of function allele ethyl methanesulfonate 0 -- Cp190CB04933 P-element activity 0 Yes Cp190H31-2 ethyl methanesulfonate 0 Yes Cp190H4-1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Cp190H53-2 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cp190 Class Mutagen Stocks Known lesion Cp190GD11908 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Cp190HMS00845 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190HMS00895 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190KK105213 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp190167-1090.T:Zzzz\His6 in vitro construct - coding region fusion 0 Yes Cp190167-271 in vitro construct 0 Yes Cp190167-321 in vitro construct 0 Yes Cp190167-468 in vitro construct 0 Yes Cp190167-608 in vitro construct 0 Yes Cp190207-321 in vitro construct 0 Yes Cp190207-608 in vitro construct 0 Yes Cp190240-321 in vitro construct 0 Yes Cp190240-608 in vitro construct 0 Yes Cp190266-608 in vitro construct 0 Yes Cp190309-427 in vitro construct 0 Yes Cp190309-456 in vitro construct 0 Yes Cp190309-608 in vitro construct 0 Yes Cp190385-508 in vitro construct 0 Yes Cp190421-608 in vitro construct 0 Yes Cp190428-608 in vitro construct 0 Yes Cp190451-608 in vitro construct 0 Yes Cp190504-789 in vitro construct 0 Yes Cp190646-937 in vitro construct 0 Yes Cp190784-1090 in vitro construct 0 Yes Cp190Ubi-p63E.PB in vitro construct - regulatory fusion 0 Yes Cp190Δ175 in vitro construct 0 Yes Cp190ΔM.Ubi-p63E in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)E(mod)4-1P1 (Pai et al., 2004) Df(3R)E(mod)4-1P11 (Pai et al., 2004) Df(3R)Exel7323 (Ryder, 2004.4.26) Df(3R)P280-NR27 (Butcher et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11908} NA P{KK105213} NA P{TRiP.HMS00845} NA P{TRiP.HMS00895} NA characterization construct P{Ubi-Cp190.D} NA P{Ubi-Cp190.ΔM} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Cp190G5211 NA P{EPgy2}Cp190EY20997 NA miscellaneous insertions P{PTT-GB}Cp190CB04933 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
chromatin insulator sequence binding inferred from direct assay (Mohan et al., 2007) microtubule binding inferred from direct assay (Butcher et al., 2004)
Biological Process
CV term Evidence References
nuclear axial expansion inferred from mutant phenotype (Chodagam et al., 2005)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Whitfield et al., 1988, Prigent et al., 2005, Butcher et al., 2004, Chodagam et al., 2005) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nucleus inferred from direct assay (Butcher et al., 2004)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
centrosome non-traceable author statement (Whitfield, 1995.7.6) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cp190 allele Gene References unspecified mod(mdg4) (Pai et al., 2004) sqh (Chodagam et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66912 DroID - A comprehensive database of gene and protein interactions. • FBgn0000283 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41848
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11747 Dere\GG20737 Dgri\GH18747 Dmoj\GI24664 Dper\GL12069 Dpse\GA19554 Dsec\GM11488 Dsim\Cen190 Dvir\GJ24037 Dwil\GK13490 Dyak\Cen190
Curated drosophilid orthologs	Dmer\Cp190   Dpse\GA19554   Dsim\Cen190 (Begun, 2000.4.5) Dyak\Cen190 (Begun, 2000.4.7)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002771-PA Aedes aegypti (mosquito) XP_001120745.1 Apis mellifera (honey bee) XP_001950912.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000021751 Bos taurus (bovine) ENSCINP00000014756 Ciona intestinalis (sea squirt) CPIJ013368 Culex pipens (mosquito) 219913 Daphnia pulex (daphnia) ENSDARP00000094731 Danio rerio (zebra fish) PHUM007807-PA Pediculus humanus (human body louse) XP_968877.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14388 NV17180 LH13036 FBgn0041646 FBgn0215498 FBgn0211124 FBgn0210533 FBgn0041670 FBgn0180645 FBgn0166431 FBgn0250257 JGI_V11_219913 FBgn0079550 FBgn0162346 FBgn0149677 FBgn0147386 FBgn0129704 FBgn0126214 FBgn0112924 FBgn0088787 CPIJ013368 BGIBMGA001575 ACYPI003627 GB17743 AGAP001794 AAEL002771 PHUM234130 GLEAN_11466
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	31792 w1118; P{EP}Cp190G5211 22440 y1 w67c23; P{EPgy2}Cp190EY20997 33903 y1 sc* v1; P{TRiP.HMS00845}attP2 33944 y1 sc* v1; P{TRiP.HMS00895}attP2/TM3, Sb1
VDRC	v108694 P{KK105213}VIE-260B v35077 w1118; P{GD11908}v35077 v35078 w1118; P{GD11908}v35078
Genomic Clones ( 2 )
	BACR13A02 BACR32A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD02352
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02009 GM23328 HL01616 LD02848 LD03980 LD04376 LD06517 LD08796 LD09366 LD11188 LD13843 LD14803 LD15565 LD21393 LD21770 LD22923 LD24882 LD26683 LD26695 LD27517 LD28204 LD30001 LD31340 LD37038 LD37194 LD37328 LD37575 LD43170 LD43176 LD45532 LD47453 LD47491 LD47777 LD48072 RE04358 RE05828 RE45084 RE53080 RE56219 RE57986 RE60983 RE68874 RE73077 SD01963 SD02115 SD03572 SD04261 SD05168 SD05172 SD07866 SD13965
Other clones	35025 40342 108156 109090 167419 176697 191076 192646 524326 525067 CK01.15D.C12 CK01.54C.G6 CK01.76B.H10 CK01.125D.A8 Dmel_dig_014178_0683_2772 Dmel_dig_018438_0644_1184 Dmel_neb_012344_0917_1117 Dmel_neb_014504_0904_2589 Dmel_neb_014553_0113_2724 EK044259 EK059563 EK063506 EK139544 EK173157 EK202101 EK272217 EK277808 EK281725 EN05156 RP003049625 RP003062996 RP003089496 RP003236295 RP003252739 RP003293797 RP003328565 RP003329663 RP003335126 RP003371808 RP003374525 RP003451410 RP003451785 RP003466432 RP003474150 RP003524521 RP003570071
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41848
Antibody Information
	polyclonal (Moshkovich et al., 2011, Whitfield et al., 1988, Wallace et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cen190 CG6384 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Cp190 protein in 0-12 hr embryos; see Insulator_Class_I.mE01 collection report. Individual protein-binding experiments listed under "Samples" at GEO: 16245 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16245). (Nègre et al., 2010) Cp190 proteins can be modified by smt3. (Capelson and Corces, 2006) Map60 (Butcher et al., 2004) The introduction of dsRNA made from templates generated with primers directed against this gene into S2 cells prevents the accumulation of Map60 to mitotic centrosomes. (Butcher et al., 2004) Cp190 plays an essential role in flies that is independent of its association with centrosomes or microtubules. (Butcher et al., 2004) Cp190 mutations act as recessive suppressors of gypsy-induced phenotypes, suggesting that Cp190 is an essential component of the gypsy insulator. (Pai et al., 2004) Cp190 requires su(Hw) in order to bind to the insulator present in the gypsy retrotransposon, but su(Hw) is not necessary for the interaction of Cp190 with endogenous insulator sites. (Pai et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Fluorescently labelled bacterially expressed Cp190 is injected into living embryos and protein behaviour during the rapid syncytial blastoderm divisions (nuclear cycles 10-13) is followed. (Oegema et al., 1997) The localisation of Cp190 protein within the fertilised egg has been studied. (Riparbelli et al., 1997) The region between amino acids 385 and 508 of the Cp190 protein is sufficient for good centrosomal localisation. A nuclear localisation domain is located between amino acids 201 and 271. (Oegema et al., 1995) Cp190 is associated with the centrosome during mitosis and during interphase the protein is associated with a large number of specific chromosomal sites. Cp190 binds to chromatin in association with another centrosomal protein, Map60. (Whitfield et al., 1995) By using monoclonal antibodies that recognize protein components of the mitotic apparatus to screen expression libraries, Cen185, which encodes a protein associated with the centrosome, was cloned. (Whitfield et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079635 NM_169632 RefSeq (Proteins) • NP_524359 NP_731998 DDBJ / EMBL / GenBank • AA202220 AAF55159 AAN13643 AAQ22559 AW941502 BT010090 CAA90324 Z50021 Entrez Gene - A searchable database of RefSeq genes. • 41848 UniProtKB/TrEMBL • Q24478
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66912 DroID - A comprehensive database of gene and protein interactions. • FBgn0000283 DRSC - Results from RNAi screens. • FBgn0000283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6384-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41848 InParanoid A subset of ortholog calls from InParanoid. • AAEL002771-PA Aedes aegypti (mosquito) XP_001120745.1 Apis mellifera (honey bee) XP_001950912.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000021751 Bos taurus (bovine) ENSCINP00000014756 Ciona intestinalis (sea squirt) CPIJ013368 Culex pipens (mosquito) 219913 Daphnia pulex (daphnia) ENSDARP00000094731 Danio rerio (zebra fish) PHUM007807-PA Pediculus humanus (human body louse) XP_968877.2 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cp190.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41848 modMine - Data generated by the modENCODE project. • FBgn0000283 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14388 NV17180 LH13036 FBgn0041646 FBgn0215498 FBgn0211124 FBgn0210533 FBgn0041670 FBgn0180645 FBgn0166431 FBgn0250257 JGI_V11_219913 FBgn0079550 FBgn0162346 FBgn0149677 FBgn0147386 FBgn0129704 FBgn0126214 FBgn0112924 FBgn0088787 CPIJ013368 BGIBMGA001575 ACYPI003627 GB17743 AGAP001794 AAEL002771 PHUM234130 GLEAN_11466
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	AbS1-4   Bx63 (Sunkel et al., 1995, Foe et al., 1993, ) Bx-63 (Semeshin et al., 2002) Cen185 (Whitfield et al., 1988) CEN190 (Izumi et al., 2004) Cen190 (Bauer-DuMont et al., 2004, Zraly et al., 2002, Li and Kaufman, 1996, Glover et al., 1995, Cambiazo et al., 1993, ) CG6384 (Goldstein and Gunawardena, 2000, Keleman et al., 2009.8.5, Hughes et al., 2008, Ni et al., 2010.12.1) CP-60 (Vidwans and O'Farrell, 1999) CP190 (Bettencourt-Dias et al., 2005, Debec et al., 2001, Deak et al., 2003, Terada et al., 2003, Prigent et al., 2005, Kaltschmidt and Brand, 2002, Marshall, 2003, Staeva-Vieira et al., 2003, Riparbelli and Callaini, 2003, Fung et al., 2002, Begun, 2001, Nickerson, 2001, Donaldson et al., 2001, Loppin et al., 2001, Barbosa et al., 2000, Sisson et al., 2000, Goldstein and Gunawardena, 2000, Callaini et al., 1999, Johansen et al., 1999, Yucel et al., 2000, Lemos et al., 2000, Begun and Whitley, 2000, Brent et al., 2000, Kaltschmidt et al., 2000, Whitfield, 1995.7.6, Debec et al., 1999, Vaizel-Ohayon and Schejter, 1999, Cullen et al., 1999, Robinson et al., 1999, Oegema, 1998, Megraw et al., 1999, Avides and Glover, 1999, Llamazares et al., 1999, Gonzalez et al., 1998, Glover et al., 1998, Gonzalez et al., 1998, Moritz et al., 1998, Wilson and Borisy, 1998, Adams et al., 1998, Riparbelli and Callaini, 1998, Kodjabachian et al., 1998, Sibon et al., 1997, Reed and Orr-Weaver, 1997, Riparbelli et al., 1997, Oegema et al., 1997, Callaini et al., 1997, Ohkura et al., 1997, Sibon and Theurkauf, 1996, Philp and Glover, 1997, Frenz and Glover, 1996, Riparbelli and Callaini, 1996, Oegema et al., 1995, Whitfield et al., 1995, Moritz et al., 1995, Capelson and Corces, 2005, Lei, 2007, Akbari et al., 2007, Capelson and Corces, 2006, McHugh et al., 2004, Basto et al., 2006, Richter et al., 2011, Sultana et al., 2011, Pai et al., 2004, Barros et al., 2005, Cullen et al., 2005, Rodrigues-Martins et al., 2007, Mottier et al., 2008, Georgiev et al., 2008, Lei et al., 2008, Oliver, 2008, Akbari et al., 2008, Blagden and Glover, 2003, Gerasimova et al., 2007, Golovnin et al., 2007, Mohan et al., 2007, Raynaud-Messina et al., 2004, Riparbelli and Callaini, 2005, Basto et al., 2007, Rogers et al., 2008, Akbari et al., 2009, Meireles et al., 2009, Ducat et al., 2008, Schaaf et al., 2009, Lei and Corces, 2006, Rach et al., 2011, Nègre et al., 2010, van Bemmel et al., 2010, modENCODE Consortium et al., 2010, Schoborg and Labrador, 2010, Ma and Jarman, 2011, Wallace et al., 2010, Erokhin et al., 2010, Guertin and Lis, 2010, Vatolina et al., 2011, Vatolina et al., 2011) CP-190 (Stevenson et al., 2001, Helps et al., 1998, Matthies et al., 1996, Gopalakrishnan et al., 2011) Cp190 (Pai et al., 2004, Buszczak et al., 2007, Bakal et al., 2007, Kwong et al., 2008, Bartkuhn et al., 2009, Oliver et al., 2010) dmap190 (Craig and Brink, 1996) DMAP190 (McKim and Hawley, 1995, Oegema et al., 1994, Wilson and Fuller, 1994, Oegema et al., 1993, Kellogg and Alberts, 1992, Postner et al., 1992, ) Dmap190 (Endow et al., 1994, ) DMAP-190 (Moritz and Alberts, 1992) E(mod)4-1 (Pai et al., 2004) Map190   Rb188 (Ceron et al., 2001, Inoue et al., 2000, Audibert and Simonelig, 1999, Mathe et al., 1998, Callaini et al., 1994, Riparbelli and Callaini, 1992, Callaini and Riparbelli, 1992, Yasuda et al., 1991, ) unnamed (Goldstein and Gunawardena, 2000)
Name Synonym	Centrosomal Protein 190 (Pai et al., 2004) Centrosomal protein 190kD (Ducat et al., 2008) E(mod)4-1 (Pai et al., 2004) Enhancer of mod(mdg4)4-1 (Pai et al., 2004)
Secondary FlyBase IDs
	FBgn0014463
References ( 174 )
Generate a list of	All references relating to this gene ( 174 )
List References by type	Research paper  ( 120 ) Supplementary material  ( 6 ) Review  ( 11 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 19 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Conference report  ( 1 )
Recent research papers ( 16 )
	Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. [FBrf0216370] Ma and Jarman, 2011, J. Cell Sci. 124(15): 2622--2630 Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation. [FBrf0214370] Moshkovich et al., 2011, Genes Dev. 25(16): 1686--1701 RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. [FBrf0214686] Rach et al., 2011, PLoS Genet. 7(1): e1001274 Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. [FBrf0214353] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sultana et al., 2011, Nucleic Acids Res. 39(9): 3543--3557 A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. [FBrf0213641] Vatolina et al., 2011, Genetika, Moscow 47(5): 597--609 [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. [FBrf0214456] Vatolina et al., 2011, Russ. J. Genet. 47(5): 521--532 Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster. [FBrf0216692] Erokhin et al., 2010, Chromosoma 119(3): 243--253 E(y)2/Sus1 is required for blocking PRE silencing by the Wari insulator in Drosophila melanogaster. [FBrf0210759] Guertin and Lis, 2010, PLoS Genet. 6(9): Chromatin Landscape Dictates HSF Binding to Target DNA Elements. [FBrf0211835] modENCODE Consortium et al., 2010, Science 330(6012): 1787--1797 Identification of functional elements and regulatory circuits by Drosophila modENCODE. [FBrf0212741] Nègre et al., 2010, PLoS Genet. 6(1): e1000814 A comprehensive map of insulator elements for the Drosophila genome. [FBrf0209760] Oliver et al., 2010, BMC Cell Biol. 11: 101 The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. [FBrf0212850] Schoborg and Labrador, 2010, J. Mol. Evol. 70(1): 74--84 The Phylogenetic Distribution of Non-CTCF Insulator Proteins Is Limited to Insects and Reveals that BEAF-32 Is Drosophila Lineage Specific. [FBrf0209931] van Bemmel et al., 2010, PLoS ONE 5(11): e15013 The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome. [FBrf0212466] Wallace et al., 2010, Chromosoma 119(2): 177--194 Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila. [FBrf0210229] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...