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General Information
Symbol
Dmel\Cf2
Species
D. melanogaster
Name
Chorion factor 2
Annotation Symbol
CG11924
Feature Type
FlyBase ID
FBgn0000286
Gene Model Status
Stock Availability
Gene Snapshot
Chorion factor 2 (Cf2) encodes a zinc-finger DNA-binding transcription factor that is involved in follicle cell fate determination and regulation of myogenic gene expression. [Date last reviewed: 2019-03-07]
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:4,876,891..4,883,107 [-]
Recombination map

2-14

RefSeq locus
NT_033779 REGION:4876891..4883107
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Transcriptional regulator; binds to the promoter region of Cp15. Also binds to its own promoter, thus having a probable autoregulatory role.
(UniProt, P20385)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
cf2
Encodes a protein that binds the promoter region of Cp15.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Cf2 or the JBrowse view of Dmel\Cf2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAG) postulated; protein extension supported (FBrf0223513).

Gene model reviewed during 6.16

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089649
3763
510
FBtr0089648
3679
482
FBtr0089647
3703
482
FBtr0304887
4231
482
FBtr0336835
3576
431
FBtr0472669
3703
537
Additional Transcript Data and Comments
Reported size (kB)

3.6, 2.65 (northern blot); 3.8 (compiled cDNA)

3.5, 2.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088592
56.7
510
7.54
FBpp0088591
53.5
482
7.27
FBpp0088590
53.5
482
7.27
FBpp0293426
53.5
482
7.27
FBpp0307799
48.3
431
7.26
FBpp0422630
58.6
537
7.37
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

482 aa isoforms: Cf2-PB, Cf2-PC, Cf2-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

514, 510, 482 (aa)

Comments

One of several products generated by alternative splicing.

The binding properties of the Cf2 protein

isoform I was studied in binding studies with oligonucleotides. Each

finger of the COOH-terminal domain recognizes a contiguous nucleotide

triplet in an antiparallel manner. The optimal targets are GTA for finger

6, TAT for fingers 5 and 5', and ATA for finger 4. The consensus binding

site is GTA.TAT.TAT.ATA where the dots delimit the triplets recognized by

each finger. Protein isoforms I and II recognize different DNA sequences,

suggesting that in vivo these isoforms regulate distinct genes.

The binding properties of Cf2 protein isoform II was studied in binding studies with oligonucleotides. Each finger of the COOH-terminal domain recognizes a contiguous nucleotide triplet in an antiparallel manner. The optimal targets are GTA for finger 6, TAT for finger 5, and ATA for finger 4. The consensus binding site is GTA.TAT.ATA where the dots delimit the triplets recognized by each finger. Protein isoforms I and II recognize different DNA sequences, suggesting that in vivo these isoforms regulate distinct genes.

The binding properties of the Cf2 protein isoform I was studied in binding studies with oligonucleotides. Each finger of the COOH-terminal domain recognizes a contiguous nucleotide triplet in an antiparallel manner. The optimal targets are GTA for finger 6, TAT for fingers 5 and 5'', and ATA for finger 4. The consensus binding site is GTA.TAT.TAT.ATA where the dots delimit the triplets recognized by each finger. Protein isoforms I and II recognize different DNA sequences,suggesting that in vivo these isoforms regulate distinct genes.

Three different protein isoforms of Cf2 are generated as a result of alternate splicing of the Cf2 transcript. All three contain three amino-terminal Zn fingers which do not appear to contribute to specific DNA sequence recognition. Isoform III contains no other Zn-fingers as a result of the absence of exon 3 and the resultant frameshift.

Three different protein isoforms of Cf2 are generated as a result of alternate splicing of the Cf2 transcript. All three contain three amino-terminal Zn fingers which do not appear to contribute to specific DNA sequence recognition. Isoform II contains 3 additional fingers, each of which recognizes a contiguous nucleotide triplet in an antiparallel manner. The preferred DNA binding sites were defined in a companion paper (FBrf 57626). A nearly perfect consensus sequence for isoform II is found in the Cp15 promoter. Protein isoforms I and II recognize different DNA sequences, suggesting that in vivo these isoforms regulate distinct genes.

Three different protein isoforms of Cf2 are generated as a result of alternate splicing of the Cf2 transcript. All three contain three amino-terminal Zn fingers which do not appear to contribute to specific DNA sequence recognition. Isoform I contains 4 additional fingers, each of which recognizes a contiguous nucleotide triplet in an antiparallel manner. The preferred DNA binding sites were defined in a companion paper (FBrf 57626). The Cf2 gene itself has a possible Cf2 isoform I protein recognition sequence suggesting that isoform I may be used to autoregulate Cf2 expression. Protein isoforms I and II recognize different DNA sequences, suggesting that in vivo these isoforms regulate distinct genes.

Cf2 protein is a DNA-binding protein that binds to specific elements of the Cp15 promoter that have been shown to be important for in vivo expression. The major Cf2 protein-binding site overlaps that of usp protein but is shifted slightly upstream.

External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cf2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001227002
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001227002
(assigned by GO_Central )
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001227002
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001227002
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
RNase protection, primer extension, SI map
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
enzyme assay or biochemical detection
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Cf2 protein is present in nuclear extracts from ovaries.

Cf2 protein is not detected until embryonic stage 15.

Cf2 protein is present in ovarian follicles.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cf2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cf2
Transgenic constructs containing regulatory region of Cf2
Deletions and Duplications ( 4 )
Phenotypes
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
 
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (14)
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
No
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
Yes
1 of 13
Yes
No
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
1 of 12
Yes
No
1 of 12
Yes
No
Danio rerio (Zebrafish) (22)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (3)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
1 of 15
Yes
Yes
1 of 15
Yes
No
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907M5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915069Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0677 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G034R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (37)
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map

    2-14

    Cytogenetic map
    Sequence location
    2L:4,876,891..4,883,107 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    25B1-25B1
    Limits computationally determined from genome sequence between P{lacW}l(2)k10004k10004&P{EP}CG3036EP963 and P{PZ}l(2)0571405714
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    25A5-25A8
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (10)
    Genomic Clones (12)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (17)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: Cf2 BcDNA:GM09668

    Additional comments

    Source for merge of Cf2 BcDNA:GM09668 was a shared cDNA ( date:030728 ).

    Other Comments

    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

    Cf2 protein is a target of down-regulation by the MAPK kinase cascade during oogenesis and this down-regulation is independent of rho function.

    Cf2 zinc fingers function in DNA binding in vitro and in vivo and site-specific mutagenesis and binding site selection define the critical amino acid-base interactions in detail.

    Cf2 protein functions as a repressor of dorsally expressed genes.

    Ectopic expression or depletion of Cf2 alters the dorsoventral polarity of the egg chamber. Mosaic analysis suggests that loss of Cf2 can lead to overproduction of dorsal appendage material. Ectopic expression of Cf2 counteracts the dorsalising effect of fs(1)K10 mutants but exacerbates heterozygous Egfr torpedo mutant phenotypes.

    Tm1 regulatory regions have high affinity binding sites for Cf2, gel mobility shift assays reveal that Cf2 recognises a target site in the Tm1 enhancer region located in the first intron.

    Cf2 plays a central role in the grk - Egfr signal transduction process in the follicle cells.

    Cf2-I and Cf2-II, the two major forms of chorion transcription factor, differ by an extra Zn-finger within DNA binding domain, due to alternative splicing. Preferred DNA binding sites were determined for each by in vitro binding studies and are distinguished by internal duplication of TAT in the site recognised by form with extra finger. Modular interactions between fingers and trinucleotides together with alternative splicing of Cf2 cause altered binding specificity and target site recognition by DNA binding domains. Cf2-II binding is to AT-rich regions in the Cp15 promoter.

    Cf2 transcripts are subject to developmentally regulated alternative splicing, to generate protein isoforms that differ in the number of Zn fingers. These different products bind to distinct promoters and DNA target sequences: Cf2-II isoform binds tightly to Cp15 chorion gene promoter whereas Cf2-I binds only weakly, but Cf2-I binds to the Cf2 promoter itself whereas Cf2-II doesn't.

    Molecular cloning and characterization has shown Cf2 to be a novel member of the zinc finger protein superfamily: Cf2 protein has zinc fingers of the C2H2 type.

    Encodes a protein that binds the promoter region of Cp15.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 59 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (10)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (98)