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Gene Dmel\cg

General Information
Symbol	Dmel\cg	Species	D. melanogaster
Name	combgap	Annotation symbol	CG8367
Feature type	protein_coding_gene	FlyBase ID	FBgn0000289
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	mig
Genomic Location
Chromosome (arm)	2R	Recombination map	2-71.1
Cytogenetic map	50E1-50E1	Sequence location	2R:10,061,198..10,070,343 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: imaginal disc-derived wing morphogenesis. 32 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; adult mesothoracic segment; thoracic segment; organ system; multi-cell-component structure; sensillum; antennal segment; larval thorax; sense organ. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1630717_s_at completely aligns to an exonic region common to each of the 8 FlyBase-annotated transcript isoforms of cg. Gene sequence location is 2R:10061198..10070343.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cg: comb gap cg: comb gap From Bridges and Brehme, 1944, Carnegie Inst. Washington Publ. No. 552: 40. Sex combs of male extremely large. Number of sex comb teeth increased from 10 to 18; number of bractless bristles increased; width of distal portion of basitarsus increased 1.6 fold; total number of bristles on basitarsus increased in both sexes (Datta and Mukherjee, 1968, Proc. XII Int. Congr. Genet. 1: 146; 1971, Genetics 68: 269-86). Some distortion and shortening of legs. Wings show gap in vein L4 between posterior crossvein and margin. Wings slightly curved. Effects result from a combination of overgrowth and irregular folding of imaginal rudiments during the pupal period. Strong exaggeration in compound homozygotes with genes such as d, fj, ds, and ssa. Double heterozygote for cg and ci often shows gap in L4 (Waddington, 1952, J. Genet. 51: 243-58). Double heterozygote en cg/++ has slight degree of L4 interruption and thinning at low temperature. Triple heterozygote en cg/++; ci/+ has L4 interruption in half the flies (House, 1961, Genetics 46: 871). ciW interacts strongly with cg. cg/+; ciW/+ resembles ciW/ciW (House, 1953, Genetics 38: 669-70). Sex-comb phenotype enhanced by sn or Pc/Scx (Datta and Mukherjee, 1968, Proc. XII Int. Congr. Genet. 1: 146). Females sterile. Oogenesis highly irregular (Beatty, 1949, Proc. Roy. Soc. Edinburgh B 63: 249-70). RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50E1-50E1   Limits computationally determined from genome sequence between P{lacW}mamk05821 and P{lacW}l(2)s3475s3475&P{lacW}Hsc70-5k04907
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50E1-50E2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-71.1   2-71 (Svendsen et al., 2000)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cg for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cg-RA FBtr0087529  NM_166035   2881   671 cg-RB FBtr0087527  NM_166034   3361   772 cg-RC FBtr0087528  NM_166036   2866   629 cg-RD FBtr0087526  NM_079014   3058   671 cg-RF FBtr0112795  NM_001103835   5066   770 cg-RI FBtr0290034  NM_001144194   3364   773 cg-RJ FBtr0290035  NM_001103834   4478   825 cg-RK FBtr0339960     3040   665 cg-RL FBtr0339961     4514   837 cg-RM FBtr0339962     3385   780
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cg-PA   FBpp0086658   73.8   671   8.59     NP_725363   AAM70988 cg-PB   FBpp0086656   83.8   772   8.44     NP_725362   AAF58283 cg-PC   FBpp0086657   69.3   629   8.81     NP_725364   AAM70989 cg-PD   FBpp0086655   73.8   671   8.59     NP_523738   AAG22267 cg-PF   FBpp0111707   83.6   770   8.52     NP_001097305   ABV53793 cg-PI   FBpp0288473   83.9   773   8.44     NP_001137666   ACL83120 cg-PJ   FBpp0288474   89.7   825   8.11     NP_001097304   ABV53792 cg-PK   FBpp0308982   73.2   665   8.68       cg-PL   FBpp0308983   90.8   837   8.09       cg-PM   FBpp0308984   84.5   780   8.44
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246460   AA390974   AA541239   AA567436   AA950387   AA952158   AE013599 AAF58283   AE013599 AAG22267   AE013599 AAM70988   AE013599 AAM70989   AE013599 ABV53792   AE013599 ABV53793   AE013599 ACL83120   AF216532 AAF25954   AF276663 AAG29350   AF276663 AAG29351   AF276664 AAG29352   AI387273   AI403165   AI404476   AI511832   AI519505   AI945917   AW941860   AW942589   AX093980   AY061299 AAL28847   AY069190 AAL39335   BG632565   BG637827   BG640390   BH615049   BI230729   BI232416   BI235967   BI239953   BI352501   BI357846   BI362037   BI367500   BI580171   BP550064   BP550948   BP558153   BT001746 AAN71501   BT023511   BT100021   CA806113   CL844423   CO188654   CO189937   CO190492   CO190669   CO261884   CO262003   CO263604   CO264130   CO265243   CO269651   CO270631   CO270632   CO274156   CO274552   CO275807   CO275820   CO277689   CO277998   CO278344   CO279669   CO282149   CO282441   CO291547   CO293852   CO294110   CO300538   CO308441   CO309275   CO314261   CO316728   CO323079   CO325528   CO326543   CO331005   CO331453   CO332102   CO332155   CO342772   CZ472258   CZ472259   CZ486794   EC052079   EC053101   EC053110   EC054585   EC055967   EC056016   EC056136   EC056617   EC056631   EC060597   EC060827   EC063147   EC067773   EC067780   EC071599   EC072645   EC075298   EC078034   EC082180   EC082383   EC083543   EC083919   EC084103   EC084995   EC089018   EC090428   EC194488   EC198866   EC200214   EC200977   EC208249   EC208643   EC212686   EC214152   EC219831   EC220304   EC220932   EC223649   EC223985   EC224937   EC227700   EC229936   EC231981   EC238147   EC238212   EC241143   EC242891   EC244153   EC250940   EC257681   EC259604   EV596850   EV598716   GH948284   GH951896   GH963556
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z9M3 Q7KHK4 A1Z9M4 A8DYD2 A8DYD1 B7YZE6 A8DYD3 Q95RL3 Q8T0L4 Q9GT73 Q9NI49 Q8IGK0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Svendsen et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    129.575 Larval Midgut    37.2 Larval Hindgut    39.8 Larval Malpighian Tubules    39.2 Larval Fat Body    50.5 Larval Salivary Gland    127.1 Larval Trachea    118.125 Larval Carcass    48 Adult Head    36.9 Adult Eye    61.4 Adult Brain    150.9 Adult Thoracic-Abdominal Ganglion    111.8 Adult Crop    58 Adult Midgut    41.8 Adult Hindgut    47.6 Adult Malpighian Tubules    34.2 Adult Fat Body    46.2 Adult Salivary Gland    76.1 Adult Heart    37.15 Adult VirginFemale Spermatheca    56.9 Adult InseminatedFemale Spermatheca    58.8 Adult Ovary    201.8 Adult Testis    20.5 Adult Male Accessory Gland    39.2 Adult Carcass    42.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    36.9   NA  Eye    61.4   NA  Brain    150.9   129.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    111.8   NA  Crop    58   37.2  Midgut    41.8   39.8  Hindgut    47.6   39.2  Malpighian Tubules    34.2   50.5  Fat Body    46.2   127.1  Salivary Gland    76.1   NA  Heart    37.15   118.125  Trachea    NA   NA  VirginFemale Spermatheca    56.9   NA  InseminatedFemale Spermatheca    58.8   NA  Ovary    201.8   NA  Testis    20.5   NA  Male Accessory Gland    39.2   48  Carcass    42.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  (74) central nervous system, pupae P8  (53) head, virgin 1-day female  (33) head, virgin 4-day female  (41) head, virgin 20-day female    23 head, mated 1-day female  (37) head, mated 4-day female  (32) head, mated 20-day female    21 head, mated 1-day male  (51) head, mated 4-day male  (52) head, mated 20-day male  (49) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8  (42) carcass, larvae L3 wandering  (35) carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (65) testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (52) central nervous system, larvae L3  (74) central nervous system, pupae P8  (53) head, virgin 1-day female  (33) head, virgin 4-day female  (41) head, virgin 20-day female    23 head, mated 1-day female  (37) head, mated 4-day female  32 head, mated 20-day female    21 head, mated 1-day male  (51) head, mated 4-day male  (52) head, mated 20-day male  (49) salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8  (42) carcass, larvae L3 wandering  (35) carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (65) testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    52 central nervous system, larvae L3    74 central nervous system, pupae P8    53 head, virgin 1-day female    33 head, virgin 4-day female    41 head, virgin 20-day female    23 head, mated 1-day female    37 head, mated 4-day female    32 head, mated 20-day female    21 head, mated 1-day male    51 head, mated 4-day male    52 head, mated 20-day male    49 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    25 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    7 digestive system, 4-day adult    11 digestive system, 20-day adult    10 fat body, larvae L3 wandering    8 fat body, white prepupae    17 fat body, pupae P8    42 carcass, larvae L3 wandering    35 carcass, 1-day adult    14 carcass, 4-day adult    18 carcass, 20-day adult    15 ovary, virgin 4-day female    60 ovary, mated 4-day female    65 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    105 embryo 04-06hr    95 embryo 06-08hr    107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (105) embryo 04-06hr  (95) embryo 06-08hr  (107) embryo 08-10hr  (92) embryo 10-12hr  (63) embryo 12-14hr  (52) embryo 14-16hr  (56) embryo 16-18hr  (42) embryo 18-20hr  (34) embryo 20-22hr  (32) embryo 22-24hr  (31) larva L1  26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6  (28) larva L3 puffstage 7-9  (34) white prepupae new  (35) white prepupae 12hr  (36) white prepupae 24hr  (50) pupae 2d postWPP  (33) pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day  26 adult female 01day  (47) adult female 05day  (61) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr  105 embryo 04-06hr    95 embryo 06-08hr  107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    105 embryo 04-06hr    95 embryo 06-08hr    107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    105 embryo 04-06hr    95 embryo 06-08hr    107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (97) embryo 02-04hr  (105) embryo 04-06hr  (95) embryo 06-08hr  (107) embryo 08-10hr  (92) embryo 10-12hr  (63) embryo 12-14hr  (52) embryo 14-16hr  (56) embryo 16-18hr  (42) embryo 18-20hr  (34) embryo 20-22hr  32 embryo 22-24hr  31 larva L1  26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6  28 larva L3 puffstage 7-9  (34) white prepupae new  (35) white prepupae 12hr  (36) white prepupae 24hr  (50) pupae 2d postWPP  (33) pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day  26 adult female 01day  (47) adult female 05day  (61) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr  105 embryo 04-06hr    95 embryo 06-08hr  107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    97 embryo 02-04hr    105 embryo 04-06hr    95 embryo 06-08hr    107 embryo 08-10hr    92 embryo 10-12hr    63 embryo 12-14hr    52 embryo 14-16hr    56 embryo 16-18hr    42 embryo 18-20hr    34 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    26 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    34 white prepupae new    35 white prepupae 12hr    36 white prepupae 24hr    50 pupae 2d postWPP    33 pupae 3d postWPP    19 pupae 4d postWPP    20 adult male 01day    20 adult male 05day    23 adult male 30day    26 adult female 01day    47 adult female 05day    61 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  (32) embryonic 1182-4H  (32) embryonic GM2  (41) embryonic Kc167  (27) embryonic S1  (27) embryonic S3  (45) leg disc CME L1  (30) wing disc CME-W2  26 wing disc ML-DmD8  (43) wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  (28) wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  (35) ovary fGS/OSS  (78) ovary OSC  (59) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (54) Schneider line 2 Sg4  32 embryonic 1182-4H  32 embryonic GM2  (41) embryonic Kc167  27 embryonic S1  27 embryonic S3  (45) leg disc CME L1  30 wing disc CME-W2  26 wing disc ML-DmD8  (43) wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (48) wing disc ML-DmD21  28 wing disc ML-DmD32  29 haltere disc ML-DmD17-c3  (60) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1  (38) CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  (34) tumorous blood cells mbn2  (35) ovary fGS/OSS  (78) ovary OSC  (59) ovary OSS  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    54 Schneider line 2 Sg4    32 embryonic 1182-4H    32 embryonic GM2    41 embryonic Kc167    27 embryonic S1    27 embryonic S3    45 leg disc CME L1    30 wing disc CME-W2    26 wing disc ML-DmD8    43 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    48 wing disc ML-DmD21    28 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    60 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    38 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    34 tumorous blood cells mbn2    35 ovary fGS/OSS    78 ovary OSC    59 ovary OSS    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (27) cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult  (27) Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (59) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  (29) Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult  27 Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult  (59) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (33) Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (49) Caffeine 25 mg/ml 48 hrs, 4-day adult  29 Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    21 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    17 Cadmium 50 mM 48 hrs, 4-day adult    27 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    59 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    33 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    49 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD05357 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000289 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8367-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 cgGD1400 lethal | recessive cg3 cg07659 cgk11504 cgΔ10 partially lethal - majority die cg07659 viable cg1 cgCC01469 cgEY11199 Sterility Allele female sterile | recessive cg1 fertile cgEY11199 Other Phenotypes Allele hyperplasia | recessive cg1 neuroanatomy defective, with Scer\GAL47B cgUY2144 neuroanatomy defective, with Scer\GAL4ey-OK107 cgUY2144 visible (with cg1) cg3 cg07659 visible (with cg3) cg1 visible (with cg07659) cg1 visible | dominant cgY4 visible | recessive cg1 wild-type cg+t11.5 cg+t103 cg+t104 cg+t105 cg+t111 Phenotype manifest in Allele antenna cg1 Kenyon cell, with Scer\GAL47B cgUY2144 Kenyon cell, with Scer\GAL4ey-OK107 cgUY2144 leg cg1 macrochaeta (with cg1) cgk11504 macrochaeta (with cgk11504) cg1 mesothoracic leg cg1 mushroom body, with Scer\GAL47B cgUY2144 mushroom body, with Scer\GAL4ey-OK107 cgUY2144 prothoracic tibial preapical bristle | supernumerary (with cg3) cg07659 prothoracic tibial preapical bristle | supernumerary (with cg07659) cg3 prothoracic tibial transverse row bristle | supernumerary (with cg1) cg07659 prothoracic tibial transverse row bristle | supernumerary (with cg07659) cg1 sex comb cg1 sex comb | supernumerary cg1 cgY4 sex comb | supernumerary (with cg1) cg07659 sex comb | supernumerary (with cg3) cg07659 sex comb | supernumerary (with cg07659) cg1 cg3 ventral thoracic disc (with cg1) cg07659 ventral thoracic disc (with cg07659) cg1 ventral thoracic disc | anterior compartment cg07659 ventral thoracic disc | anterior compartment (with cg3) cg07659 ventral thoracic disc | anterior compartment (with cg07659) cg3 wing cg1 wing | anterior compartment (with cg3) cg07659 wing | anterior compartment (with cg07659) cg3 wing | posterior compartment (with cg1) cg07659 cg3 wing | posterior compartment (with cg3) cg1 wing | posterior compartment (with cg07659) cg1 wing margin | anterior cg1 wing margin | anterior (with cg1) cg07659 cg3 wing margin | anterior (with cg3) cg1 wing margin | anterior (with cg07659) cg1 wing vein (with cg1) cgk11504 wing vein (with cgk11504) cg1 wing vein L2 (with cg1) cg07659 wing vein L2 (with cg07659) cg1 wing vein L4 cg1 wing vein L4 (with cg1) cg07659 cg3 wing vein L4 (with cg3) cg1 wing vein L4 (with cg07659) cg1 wing vein L5 cg1 wing vein L5 (with cg1) cg07659 cg3 wing vein L5 (with cg3) cg1 wing vein L5 (with cg07659) cg1
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of cg Class Mutagen Stocks Known lesion cg1 spontaneous 5 Yes cgKG00882 P-element activity 2 -- cg07659 P-element activity 1 Yes cgd01489 P-element activity 1 -- cgEY11199 P-element activity 1 -- cgf03211 1 -- cgf04179 1 -- cgf04259 piggyBac transposase 1 -- cgNP5911 1 -- cgUY2144 P-element activity 1 Yes cg262 Delta2-3 0 Yes cg3 P-element activity 0 Yes cgA22 0 Yes cgCC01469 P-element activity 0 Yes cgf03266 0 -- cgk11504 P-element activity 0 Yes cgunspecified 0 -- cgY4 ethyl methanesulfonate 0 Yes cgΔ10 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cg Class Mutagen Stocks Known lesion cgGD1400 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cgHMS01145 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cgJF02523 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cgKK110530 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cg+t103 in vitro construct - genomic fragment 0 Yes cg+t104 in vitro construct - genomic fragment 0 Yes cg+t105 in vitro construct - genomic fragment 0 Yes cg+t11.5 in vitro construct - genomic fragment 0 Yes cg+t111 in vitro construct - genomic fragment 0 Yes cgdsRNA.cLa in vitro construct - RNAi 0 Yes cgGD17036 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cgScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes cgtCG248 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC18 (Deal-Herr and Cook, 2002.4.1) Df(2R)cg315 (Campbell and Tomlinson, 2000) Df(2R)Exel7130 (Ryder, 2004.4.26)
Not disrupted in	Df(2R)trix (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1400} NA P{GD17036} NA P{KK110530} NA P{TRiP.HMS01145} NA P{TRiP.JF02523} NA P{UAS-cg.S} NA characterization construct P{cg+t11.5} NA P{cg+t103} NA P{cg+t104} NA P{cg+t105} NA P{cg+t111} NA P{cgCG248} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}cg1 NA ?{}cg3 NA P{PTT-GC}cgCC01469 NA P{SUPor-P}cgKG00882 NA PBac{WH}cgf03211 NA PBac{WH}cgf03266 NA PBac{WH}cgf04179 NA PBac{WH}cgf04259 NA insertion of enhancer trap P{lacW}cgk11504 No P{lacW}l(2)SH0415SH0415 No P{PZ}cg07659 No insertion of enhancer trap binary system P{GawB}cgNP5911 No insertion of mobile activating element P{EPgy2}cgEY11199 NA P{Mae-UAS.6.11}cgUY2144 NA P{XP}cgd01489 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Svendsen et al., 2000)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Svendsen et al., 2000)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity non-traceable author statement (Song, 1999.12.14) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Song, 1999.12.14)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cg - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cg allele Gene References cg1 ci (House, 1953, Svendsen et al., 2000) d (Waddington, 1953) ds (Waddington, 1953) en (House, 1961) fj (Waddington, 1953) l(2)gd1 (Buratovich and Bryant, 1997) ss (Waddington, 1953) cg3 ci (Svendsen et al., 2000) cg262 ci (Campbell and Tomlinson, 2000) cg07659 ci (Campbell and Tomlinson, 2000, Svendsen et al., 2000) en (Campbell and Tomlinson, 2000) cgY4 en (Campbell and Tomlinson, 2000) unspecified ds (Buratovich and Bryant, 1997) en (House, 1953, House, 1953, Mukherjee, 1965, Datta and Mukherjee, 1971, Svendsen et al., 2000) inv (Svendsen et al., 2000) rho (Sturtevant and Bier, 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62322 DroID - A comprehensive database of gene and protein interactions. • FBgn0000289 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36571
Orthologs
OrthoDB Orthologs (26) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67PXRJ Dipteran inclusive ortholog search EOG6HT91V Insect inclusive ortholog search EOG6WM3Q8 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG67PXRJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cg     Drosophila simulans   Dsim\GD11028 Y   Drosophila sechellia   Dsec\GM21517 Y   Drosophila erecta   Dere\GG20430 Y   Drosophila yakuba   Dyak\GE13562 Y   Drosophila ananassae   Dana\GF12033 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21024 Y   Drosophila persimilis   Dper\GL17206 Y   Drosophila willistoni   Dwil\GK21553 Y   Drosophila virilis   Dvir\GJ20060 Y   Drosophila mojavensis   Dmoj\GI19087 Y
Orthologs in non-Drosophila Dipterans (EOG6HT91V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001526   Anopheles gambiae Malaria mosquito  Agam\AGAP011566   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011148
Orthologs in non-Dipteran Insects (EOG6WM3Q8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC411099   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018556   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18420   Atta cephalotes Leafcutter ant  Acep\ACEP10523   Camponotus floridanus Florida carpenter ant  Cflo\CFLO25171   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13963   Linepithema humile Argentine ant  Lhum\LH17867   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22825   Solenopsis invicta Red fire ant  Sinv\SINV20712   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002808   Bombyx mori Silkmoth  Bmor\BGIBMGA005268   Tribolium castaneum Red flour beetle  Tcas\TC006712
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11028 Drosophila sechellia Dsec\GM21517 Drosophila erecta Dere\GG20430 Drosophila yakuba Dyak\GE13562 Drosophila ananassae Dana\GF12033 Drosophila pseudoobscura pseudoobscura Dpse\GA21024 Drosophila persimilis Dper\GL17206 Drosophila willistoni Dwil\GK21553 Drosophila virilis Dvir\GJ20060 Drosophila mojavensis Dmoj\GI19087 Drosophila grimshawi Dgri\GH21844
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	252 cg1 c1/SM5 29359 y1 v1; P{TRiP.JF02523}attP2 253 cg1 c1/In(2LR)U, U1
Harvard	- P{XP}cgd01489 - PBac{WH}cgf03211 - PBac{WH}cgf04179 - PBac{WH}cgf04259
Kyoto	105816 cg1 c1/In(2LR)U, U1 105838 dw-24E1 l(2)cg1 cg1/SM5
VDRC	v102054 P{KK110530}VIE-260B v2965 w1118; P{GD1400}v2965 v2966 w1118; P{GD1400}v2966
	More stocks available...
Genomic Clones ( 2 )
	BACR30O03 BACR33A10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 117 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH24215 LD05357 LD21089 RE74316
Other clones	MIP14692
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH10680 GH17758 GH22549 GM19555 HL01186 LD09770 LD29233 LD39122 LD43364 RE14757 RE28478 RE31939 RE36584 RE44438 RE46490 RE53274 SD11392
Other clones	12610 12757 17941 28300 28976 31182 32465 44456 57560 63652 64162 69675 70228 74751 75128 83432 108831 149528 153069 154644 162339 194218 214417.27 214417.28 272523 274751 274972 bs18c10 CK01.6C.F1 CK01.49D.H4 CK01.60D.B12 CK01.106C.C6 CK01.110B.G4 CK01.110B.G6 CK01.125A.A10 CK01.144A.H11 CK01.144A.H12 CK01.169A.D2 Dmel_neb_011547_0889_2851 Dmel_neb_012732_0823_3435 EC052079 EC053101 EC053110 EC054585 EC055967 EC056016 EC056136 EC056617 EC056631 EK041362 EK045702 EK048356 EK049030 EK081143 EK083558 EK089043 EK095435 EK099558 EK099559 EK113411 EK114445 EK118730 EK118762 EK125826 EK128102 EK129828 EK135612 EK137552 EK142019 EK159634 EK160505 EK178456 EK189628 EK196723 EK197620 EK204961 EK206025 EK217060 EK235545 EK258156 EK265730 EK297215 EK299827 EK302522 EK302638 EP04116 EP15501 ESG012a.E21_C04 FGM105B01 FGM210B03 FGM313C08 LD28926 RP004152020 RP004198356 RP004513549
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000289 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36571
Antibody Information
Other Information
Discoverer
	Bridges, 16th Nov. 1925.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cg l(2)07659 (Campbell and Tomlinson, 2000) Source for merge of: cg mig (Kunes, 2000.10.23) Source for merge of: mig CG8367 (Bayraktaroglu, 2000.8.7)
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Area matching Drosophila EST AA246460 (inverted). (Davies, 2001.3.15) cg is required for normal regulation of transcription of ci. Overall orientation not stated: cg- anon-50Ea- (Campbell and Tomlinson, 2000) cg is required for the correct regulation of ci in limb development. (Svendsen et al., 2000) Identification: Screen for mutants defective in the retinal axon projections. (Chung and Kunes, 1997) cg is required for the establishment of radial pattern. (Chung and Kunes, 1997) In cg mutants, dividing cells that are normally confined to specific radial domains fail to respect their radial domains. (Chung and Kunes, 1997) Loss of vein mutations cause suppression of rhohs.PSt ectopic vein phenotype and enhancement of the rhove-1 loss of vein phenotype. (Sturtevant and Bier, 1995) Mutations in cg cause pleiotropic phenotypes in embryonic patterns and affect several longitudinal veins. (Diaz-Benjumea and Garcia-Bellido, 1990) ve, vn, ci, cg, svs, ast, H, Vno and vvl belong to the vein phenotypic group (Puro, 1982, Droso. Info. Serv. 58:205--208) within the 'lack-of-vein' mutant class. Loss-of-function alleles at these loci remove stretches of veins in two or more longitudinal veins. Double mutations within members of this group remove all veins, have smaller, slightly lanceolate wings, no sensilla and extra chaetae. cg mutants exhibit pleitrophic effects in leg development. (Diaz-Benjumea et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079014 NM_166034 NM_166035 NM_166036 NM_001103834 NM_001103835 NM_001144194 RefSeq (Proteins) • NP_523738 NP_725362 NP_725363 NP_725364 NP_001097304 NP_001097305 NP_001137666 DDBJ / EMBL / GenBank • AA246460 AA541239 AAF25954 AAF58283 AAG22267 AAG29350 AAG29351 AAG29352 AAL28847 AAL39335 AAM70988 AAM70989 AAN71501 ABV53792 ABV53793 ABV53794 ACL83120 AF216532 AF276663 AF276664 AI404476 AI945917 AW941860 AW942589 AX093980 AY061299 AY069190 BG637827 BH615049 BI580171 BT001746 CL844423 CZ472258 CZ472259 CZ486794 Entrez Gene - A searchable database of RefSeq genes. • 36571 UniProtKB/TrEMBL • A1Z9M3 A1Z9M4 A8DYD1 A8DYD2 A8DYD3 B7YZE6 Q7KHK4 Q8IGK0 Q8T0L4 Q9GT73 Q9NI49 Q95RL3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD05357
Linkouts
	BioGRID - A database of protein and genetic interactions • 62322 DroID - A comprehensive database of gene and protein interactions. • FBgn0000289 DRSC - Results from RNAi screens. • FBgn0000289 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000289 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8367-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000289 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36571 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/combgap1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36571 modMine - Data generated by the modENCODE project. • FBgn0000289
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	cg (Zhang et al., 2006, Buszczak et al., 2007, McClure and Schubiger, 2008, Weake et al., 2011, Beltran et al., 2007, Pilgram et al., 2011) CG8367 (Kunes, 2000.10.23, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) l(2)07659 (BDGP Project Members, 1994-1999, ) l(2)k11504 (Song et al., 2000) mig (Boutros et al., 2004, Kunes, 2000.10.23, Chung and Kunes, 1997, Chung and Kunes, 1997, Chung and Kunes, 1997, )
Name Synonym	comb gap (Crozatier et al., 2004) combgap (Nybakken et al., 2005, McClure and Schubiger, 2008) Combgap (Minervini et al., 2007) migraine (Chung and Kunes, 1997)
Secondary FlyBase IDs
	FBgn0010639 FBgn0020273 FBgn0033908
References ( 70 )
Generate a list of	All references relating to this gene ( 70 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 8 ) FlyBase analysis  ( 2 ) Patent  ( 1 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Book  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Brooks et al., 2011, Genome Res. 21(2): 193--202 Conservation of an RNA regulatory map between Drosophila and mammals. [FBrf0213079] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...