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Gene Dmel\chic

General Information
Symbol	Dmel\chic	Species	D. melanogaster
Name	chickadee	Annotation symbol	CG9553
Feature type	protein_coding_gene	FlyBase ID	FBgn0000308
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	sand, Chi
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	26A5-26B2	Sequence location	2L:5,972,115..5,981,025 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene chickadee is referred to in FlyBase by the symbol Dmel\chic (CG9553, FBgn0000308). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 12 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; multicellular organismal reproductive process; biological regulation; central nervous system development; localization; cellular process involved in reproduction; cell division; ovarian nurse cell to oocyte transport; organ development. 67 alleles are reported. The phenotypes of these alleles are annotated with: organ system; female germline cyst; organ system subdivision; egg; spermatocyte; adult segment; portion of tissue; sensillum; nervous system; multi-cell-component structure. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Profilin, plant; Profilin/allergen. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640251_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of chic. Gene sequence location is 2L:5972115..5981025.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	chic: chickadee (T. Schupbach) Female sterile; nurse cell contents are not transported into the egg, and homozygous females lay tiny eggs, which remain unfertilized.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features HFA03507 BKN32358
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26A5-26B2   Limits computationally determined from genome sequence between P{EP}bchsEP2299&P{EP}GpdhEP466 and P{lacW}chick13321
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26A5-26A6   (determined by in situ hybridisation)   (Spradling et al., 1999) 26A-26A   (determined by in situ hybridisation)   (Giansanti et al., 1998) 26A-26A   (determined by in situ hybridisation)   (Cooley et al., 1992)
Experimentally Determined Recombination Data
Location	2- (van Vactor et al., 1993)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\chic for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) chic-RA FBtr0079233  NM_057668   1012   126 chic-RB FBtr0079235  NM_134304   1399   126 chic-RC FBtr0079234  NM_164667   1513   126 chic-RD FBtr0079236  NM_205913   2098   126 chic-RE FBtr0309212     995   126 chic-RF FBtr0309213     1272   126
Additional Transcript Data & Comments
Reported size (kB)	1.2, 1.0 (northern blot) (Cooley et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein chic-PA   FBpp0078864   13.7   126   5.05     NP_477016   AAF52315 chic-PB   FBpp0078866   13.7   126   5.05     NP_599131   AAF52316 chic-PC   FBpp0078865   13.7   126   5.05     NP_723136   AAN10565 chic-PD   FBpp0089196   13.7   126   5.05     NP_995635   AAS64643 chic-PE   FBpp0301151   13.7   126   5.05       chic-PF   FBpp0301152   13.7   126   5.05
Additional Polypeptide Data & Comments
Reported size (kDa)	126 (aa) (Cooley et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Profilin/allergen (IPR002097) Profilin, plant (IPR005455)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264383   AA390941   AA441071   AA536456   AA539100   AA540038   AA696064   AA940980   AA950192   AA950475   AE014134 AAF52315   AE014134 AAF52316   AE014134 AAN10565   AE014134 AAS64643   AC004268   AC004758   AC092239   AI062186   AI108892   AI109229   AI294292   AI296300   AI296440   AI296502   AI296568   AI389418   AI403461   AI455888   AI533537   AQ025026   AQ025993   AQ026056   AQ026482   AQ073404   AQ254819   AW942382   AY069444 AAL39589   AY128443 AAM75036   BF490195   BF501155   BG633315   BG637997   BG639219   BI163172   BI170322   BI172211   BI212413   BI214061   BI228971   BI230501   BI230788   BI235018   BI235052   BI236165   BI240335   BI241563   BI357071   BI357508   BI357537   BI358282   BI358468   BI361788   BI365307   BI366178   BI366674   BI371151   BI371681   BI374261   BI482218   BI482660   BI484455   BI485584   BI486051   BI487105   BI563627   BI564300   BI565499   BI566389   BI566479   BI566516   BI568367   BI573370   BI573371   BI574426   BI575176   BI576407   BI577356   BI577689   BI578108   BI579790   BI581548   BI582908   BI583077   BI584214   BI585491   BI587103   BI588048   BI588201   BI588648   BI588852   BI589951   BI590166   BI590352   BI590550   BI612736   BI614858   BI615409   BI615603   BI618496   BI618853   BI619589   BI621534   BI627194   BI627564   BI628243   BI628382   BI629067   BI634607   BI635926   BI637744   BP542623   BP545581   BP547927   BP549366   BP553061   BP555141   BP556350   BP556351   BP557167   BP557535   BP557536   BP558417   BQ103287   BT120346   CA804373   CA806680   CA807219   CK657625   CK658114   CK659924   CK662389   CL632151   CO152811   CO153259   CO153430   CO153544   CO153686   CO153798   CO154141   CO154427   CO154645   CO154897   CO154929   CO155089   CO155262   CO155416   CO155447   CO155562   CO155584   CO156455   CO156741   CO156818   CO156868   CO178776   CO179909   CO180398   CO180492   CO181114   CO182031   CO183247   CO183414   CO187779   CO187858   CO189160   CO191406   CO194773   CO194935   CO272021   CO274186   CO289140   CO290569   CO295281   CO299337   CO301631   CO307024   CO323052   CO323791   CO329339   CO332113   CO335393   CO335432   CO335535   CO335875   CO335899   CO335925   CO336040   CO336451   CO336667   CO337887   CO337933   CO338273   CO338373   CW848232   CZ473038   CZ477197   CZ477632   DQ062770 AAY56643   EC062200   EC064189   EC069369   EC069871   EC074622   EC077465   EC078769   EC194861   EC207678   EC207832   EC211361   EC216576   EC225578   EC227658   EC232154   EC239325   EC261597   EC262191   EC262547   EC262708   EC262938   EC263077   EC263187   EC263480   EC263871   EC264618   EC264644   EC264663   EC264712   EC265229   EC265315   EC265459   EC265509   EC265830   EC265873   EC265903   EC266523   EC266551   EC266583   EC266741   EC266742   EC267033   EC267469   EC267490   EC267805   EC267973   EV583636   EV599384   GH943111   GH943656   GH944260   GH944557   GH945840   GH946109   GH946366   GH947887   GH949026   GH949444   GH950263   GH951312   GH952957   GH953443   GH955245   GH956232   GH959406   GH960081   GH960370   GH960422   GH960758   GH961290   GH961495   GH961618   GH961811   GH962427   GH962580   GH962621   GH963220   GH963392   GH964372   GH964861   GH964982   GH968653   GH968957   GH969391   GH969782   GH970332   GH970516   GH972179   GH972239   GH972591   GH973604   GH974490   GH974878   GH975950   GH976417   GH976681   GH978354   GH979111   GH979810   GH984557   GH984630   M84528 AAA28418   M84529 AAA28419
UniProtKB/Swiss-Prot	P25843
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Cooley et al., 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Cooley et al., 1992)
Additional Descriptive Data
	The 1.2kb chi transcript is abundant in ovaries and elsewhere in adult males and females. It is present in RNA isolated from the seven chi insertion alleles tested. (Cooley et al., 1992) The 1.0kb chi transcript is ovary specific. It is absent in all seven chickadee insertion alleles. (Cooley et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Verheyen and Cooley, 1994) embryonic stage -- adult stage     (Verheyen and Cooley, 1994) embryonic stage 16   ventral nerve cord   (Verheyen and Cooley, 1994) adult stage & oogenesis   follicle cell   (Verheyen and Cooley, 1994) border follicle cell   (Verheyen and Cooley, 1994) nurse cell   (Verheyen and Cooley, 1994)
Additional Descriptive Data
	chic protein is expressed throughout development, with high levels in 12-24 hr embryos and in pupal stages, and low levels in adults. Before stage S2 of oogenesis, high levels of chic protein are detected in the cytoplasm of follicle cells, with low levels associated with the follicle cell plasma membrane. After stage S2, lower levels of cytoplasmic chic protein are detectable in both germline and somatic cells. Border follicle cells express chic protein at high levels. Expression is also detected in the nurse cell cytoplasm throughout oogenesis, with highest levels at stage S10. chic protein is expressed throughout embryogenesis, with some regions of higher expression. During gastrulation, higher expression is detected in areas of cell movement. At stage 16, the ventral nerve cord is stained. (Verheyen and Cooley, 1994)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000308    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000308 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000308 expression level Developmental Stage   Expression Level embryo 00-02hr    14815 embryo 02-04hr    24149 embryo 04-06hr    27161 embryo 06-08hr    30014 embryo 08-10hr    31880 embryo 10-12hr    31802 embryo 12-14hr    28281 embryo 14-16hr    19210 embryo 16-18hr    15054 embryo 18-20hr    10909 embryo 20-22hr    10048 embryo 22-24hr    10584 larva L1    10445 larva L2    16468 larva L3 12hr old    14340 larva L3 puffstage 1-2    22180 larva L3 puffstage 3-6    35570 larva L3 puffstage 7-9    47430 white prepupae new    49127 white prepupae 12hr    28799 white prepupae 24hr    26529 pupae 2d postWPP    19245 pupae 3d postWPP    9533 pupae 4d postWPP    14177 adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day    12672 adult female 30day    12263 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (14815) embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  (19210) embryo 16-18hr  (15054) embryo 18-20hr  (10909) embryo 20-22hr  (10048) embryo 22-24hr  (10584) larva L1  (10445) larva L2  (16468) larva L3 12hr old  (14340) larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  (19245) pupae 3d postWPP  (9533) pupae 4d postWPP  (14177) adult male 01day  (8037) adult male 05day  (9433) adult male 30day  (9350) adult female 01day  (9726) adult female 05day  (12672) adult female 30day  (12263) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (14815) embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  (19210) embryo 16-18hr  (15054) embryo 18-20hr  (10909) embryo 20-22hr  (10048) embryo 22-24hr  (10584) larva L1  (10445) larva L2  (16468) larva L3 12hr old  (14340) larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  (19245) pupae 3d postWPP  (9533) pupae 4d postWPP  (14177) adult male 01day  (8037) adult male 05day  (9433) adult male 30day  (9350) adult female 01day  (9726) adult female 05day  (12672) adult female 30day  (12263) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (14815) embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  (19210) embryo 16-18hr  (15054) embryo 18-20hr  (10909) embryo 20-22hr  10048 embryo 22-24hr  10584 larva L1  10445 larva L2  (16468) larva L3 12hr old  (14340) larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  (19245) pupae 3d postWPP    9533 pupae 4d postWPP  (14177) adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day  (12672) adult female 30day  (12263) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14815 embryo 02-04hr    24149 embryo 04-06hr    27161 embryo 06-08hr    30014 embryo 08-10hr    31880 embryo 10-12hr    31802 embryo 12-14hr    28281 embryo 14-16hr    19210 embryo 16-18hr    15054 embryo 18-20hr    10909 embryo 20-22hr    10048 embryo 22-24hr    10584 larva L1    10445 larva L2    16468 larva L3 12hr old    14340 larva L3 puffstage 1-2    22180 larva L3 puffstage 3-6    35570 larva L3 puffstage 7-9    47430 white prepupae new    49127 white prepupae 12hr    28799 white prepupae 24hr    26529 pupae 2d postWPP    19245 pupae 3d postWPP    9533 pupae 4d postWPP    14177 adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day    12672 adult female 30day    12263 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000308 expression level Developmental Stage   Expression Level embryo 00-02hr    14815 embryo 02-04hr    24149 embryo 04-06hr    27161 embryo 06-08hr    30014 embryo 08-10hr    31880 embryo 10-12hr    31802 embryo 12-14hr    28281 embryo 14-16hr    19210 embryo 16-18hr    15054 embryo 18-20hr    10909 embryo 20-22hr    10048 embryo 22-24hr    10584 larva L1    10445 larva L2    16468 larva L3 12hr old    14340 larva L3 puffstage 1-2    22180 larva L3 puffstage 3-6    35570 larva L3 puffstage 7-9    47430 white prepupae new    49127 white prepupae 12hr    28799 white prepupae 24hr    26529 pupae 2d postWPP    19245 pupae 3d postWPP    9533 pupae 4d postWPP    14177 adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day    12672 adult female 30day    12263 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (14815) embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  (19210) embryo 16-18hr  (15054) embryo 18-20hr  (10909) embryo 20-22hr  (10048) embryo 22-24hr  (10584) larva L1  (10445) larva L2  (16468) larva L3 12hr old  (14340) larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  (19245) pupae 3d postWPP  (9533) pupae 4d postWPP  (14177) adult male 01day  (8037) adult male 05day  (9433) adult male 30day  (9350) adult female 01day  (9726) adult female 05day  (12672) adult female 30day  (12263) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (14815) embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  (19210) embryo 16-18hr  (15054) embryo 18-20hr  (10909) embryo 20-22hr  (10048) embryo 22-24hr  (10584) larva L1  (10445) larva L2  (16468) larva L3 12hr old  (14340) larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  (19245) pupae 3d postWPP  (9533) pupae 4d postWPP  (14177) adult male 01day  (8037) adult male 05day  (9433) adult male 30day  (9350) adult female 01day  (9726) adult female 05day  (12672) adult female 30day  (12263) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  14815 embryo 02-04hr  (24149) embryo 04-06hr  (27161) embryo 06-08hr  (30014) embryo 08-10hr  (31880) embryo 10-12hr  (31802) embryo 12-14hr  (28281) embryo 14-16hr  19210 embryo 16-18hr  15054 embryo 18-20hr  10909 embryo 20-22hr  10048 embryo 22-24hr  10584 larva L1  10445 larva L2  16468 larva L3 12hr old  14340 larva L3 puffstage 1-2  (22180) larva L3 puffstage 3-6  (35570) larva L3 puffstage 7-9  (47430) white prepupae new  (49127) white prepupae 12hr  (28799) white prepupae 24hr  (26529) pupae 2d postWPP  19245 pupae 3d postWPP    9533 pupae 4d postWPP  14177 adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day  12672 adult female 30day  12263 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    14815 embryo 02-04hr    24149 embryo 04-06hr    27161 embryo 06-08hr    30014 embryo 08-10hr    31880 embryo 10-12hr    31802 embryo 12-14hr    28281 embryo 14-16hr    19210 embryo 16-18hr    15054 embryo 18-20hr    10909 embryo 20-22hr    10048 embryo 22-24hr    10584 larva L1    10445 larva L2    16468 larva L3 12hr old    14340 larva L3 puffstage 1-2    22180 larva L3 puffstage 3-6    35570 larva L3 puffstage 7-9    47430 white prepupae new    49127 white prepupae 12hr    28799 white prepupae 24hr    26529 pupae 2d postWPP    19245 pupae 3d postWPP    9533 pupae 4d postWPP    14177 adult male 01day    8037 adult male 05day    9433 adult male 30day    9350 adult female 01day    9726 adult female 05day    12672 adult female 30day    12263 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000308    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000308 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000308 expression level Tissue   Expression Level Larval Central Nervous System    1958.775 Larval Midgut    3262.7 Larval Hindgut    2547.4 Larval Malpighian Tubules    2555.3 Larval Fat Body    2761.4 Larval Salivary Gland    3458.4 Larval Trachea    2626.875 Larval Carcass    3396.225 Adult Head    924.8 Adult Eye    1871.95 Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop    2177.5 Adult Midgut    1440.7 Adult Hindgut    1218.5 Adult Malpighian Tubules    1063.1 Adult Fat Body    505.9 Adult Salivary Gland    1043.3 Adult Heart    1439.275 Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary    1038.5 Adult Testis    725.1 Adult Male Accessory Gland    1394 Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1958.775) Larval Midgut  (3262.7) Larval Hindgut  (2547.4) Larval Malpighian Tubules  (2555.3) Larval Fat Body  (2761.4) Larval Salivary Gland  (3458.4) Larval Trachea  (2626.875) Larval Carcass  (3396.225) Adult Head  (924.8) Adult Eye  (1871.95) Adult Brain  (886.1) Adult Thoracic-Abdominal Ganglion  (867.9) Adult Crop  (2177.5) Adult Midgut  (1440.7) Adult Hindgut  (1218.5) Adult Malpighian Tubules  (1063.1) Adult Fat Body  505.9 Adult Salivary Gland  (1043.3) Adult Heart  (1439.275) Adult VirginFemale Spermatheca  (771.4) Adult InseminatedFemale Spermatheca  (947.8) Adult Ovary  (1038.5) Adult Testis  (725.1) Adult Male Accessory Gland  (1394) Adult Carcass  (708.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1958.775) Larval Midgut  (3262.7) Larval Hindgut  (2547.4) Larval Malpighian Tubules  (2555.3) Larval Fat Body  (2761.4) Larval Salivary Gland  (3458.4) Larval Trachea  (2626.875) Larval Carcass  (3396.225) Adult Head    924.8 Adult Eye  (1871.95) Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop  (2177.5) Adult Midgut  (1440.7) Adult Hindgut  (1218.5) Adult Malpighian Tubules  1063.1 Adult Fat Body    505.9 Adult Salivary Gland  1043.3 Adult Heart  (1439.275) Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary  1038.5 Adult Testis    725.1 Adult Male Accessory Gland  (1394) Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1958.775 Larval Midgut    3262.7 Larval Hindgut    2547.4 Larval Malpighian Tubules    2555.3 Larval Fat Body    2761.4 Larval Salivary Gland    3458.4 Larval Trachea    2626.875 Larval Carcass    3396.225 Adult Head    924.8 Adult Eye    1871.95 Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop    2177.5 Adult Midgut    1440.7 Adult Hindgut    1218.5 Adult Malpighian Tubules    1063.1 Adult Fat Body    505.9 Adult Salivary Gland    1043.3 Adult Heart    1439.275 Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary    1038.5 Adult Testis    725.1 Adult Male Accessory Gland    1394 Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000308 expression level Tissue   Expression Level Larval Central Nervous System    1958.775 Larval Midgut    3262.7 Larval Hindgut    2547.4 Larval Malpighian Tubules    2555.3 Larval Fat Body    2761.4 Larval Salivary Gland    3458.4 Larval Trachea    2626.875 Larval Carcass    3396.225 Adult Head    924.8 Adult Eye    1871.95 Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop    2177.5 Adult Midgut    1440.7 Adult Hindgut    1218.5 Adult Malpighian Tubules    1063.1 Adult Fat Body    505.9 Adult Salivary Gland    1043.3 Adult Heart    1439.275 Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary    1038.5 Adult Testis    725.1 Adult Male Accessory Gland    1394 Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1958.775) Larval Midgut  (3262.7) Larval Hindgut  (2547.4) Larval Malpighian Tubules  (2555.3) Larval Fat Body  (2761.4) Larval Salivary Gland  (3458.4) Larval Trachea  (2626.875) Larval Carcass  (3396.225) Adult Head  (924.8) Adult Eye  (1871.95) Adult Brain  (886.1) Adult Thoracic-Abdominal Ganglion  (867.9) Adult Crop  (2177.5) Adult Midgut  (1440.7) Adult Hindgut  (1218.5) Adult Malpighian Tubules  (1063.1) Adult Fat Body  505.9 Adult Salivary Gland  (1043.3) Adult Heart  (1439.275) Adult VirginFemale Spermatheca  771.4 Adult InseminatedFemale Spermatheca  (947.8) Adult Ovary  (1038.5) Adult Testis  725.1 Adult Male Accessory Gland  (1394) Adult Carcass  708.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1958.775) Larval Midgut  (3262.7) Larval Hindgut  (2547.4) Larval Malpighian Tubules  (2555.3) Larval Fat Body  (2761.4) Larval Salivary Gland  (3458.4) Larval Trachea  (2626.875) Larval Carcass  (3396.225) Adult Head    924.8 Adult Eye  (1871.95) Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop  (2177.5) Adult Midgut  1440.7 Adult Hindgut  1218.5 Adult Malpighian Tubules  1063.1 Adult Fat Body    505.9 Adult Salivary Gland  1043.3 Adult Heart  1439.275 Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary  1038.5 Adult Testis    725.1 Adult Male Accessory Gland  1394 Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1958.775 Larval Midgut    3262.7 Larval Hindgut    2547.4 Larval Malpighian Tubules    2555.3 Larval Fat Body    2761.4 Larval Salivary Gland    3458.4 Larval Trachea    2626.875 Larval Carcass    3396.225 Adult Head    924.8 Adult Eye    1871.95 Adult Brain    886.1 Adult Thoracic-Abdominal Ganglion    867.9 Adult Crop    2177.5 Adult Midgut    1440.7 Adult Hindgut    1218.5 Adult Malpighian Tubules    1063.1 Adult Fat Body    505.9 Adult Salivary Gland    1043.3 Adult Heart    1439.275 Adult VirginFemale Spermatheca    771.4 Adult InseminatedFemale Spermatheca    947.8 Adult Ovary    1038.5 Adult Testis    725.1 Adult Male Accessory Gland    1394 Adult Carcass    708.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    924.8   NA  Eye    1871.95   NA  Brain    886.1   1958.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    867.9   NA  Crop    2177.5   3262.7  Midgut    1440.7   2547.4  Hindgut    1218.5   2555.3  Malpighian Tubules    1063.1   2761.4  Fat Body    505.9   3458.4  Salivary Gland    1043.3   NA  Heart    1439.275   2626.875  Trachea    NA   NA  VirginFemale Spermatheca    771.4   NA  InseminatedFemale Spermatheca    947.8   NA  Ovary    1038.5   NA  Testis    725.1   NA  Male Accessory Gland    1394   3396.225  Carcass    708.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000308 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9553-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal chick13321 lethal | dominant | maternal effect chic01320 lethal | embryonic stage chic221 lethal | recessive chic38 chic103 chic139 chic211 chic221 chic281 chic321 chick02707 chick13321 chicsand-1 chicsand-2 semi-lethal | recessive chic221 viable chicEY04675 chick13321 Sterility Allele female fertile | poor chic10 chic07886 female semi-sterile | recessive chic8A chic13 chic13E chic35A chic37 chic01320 chic07886 chicR1 female sterile chic1 chic2 chic3 chic11 chic07886 female sterile | recessive chic1 chic2 chic3 chic11 chic12 chic37 chic01320 chic04612 chic06356 chic07886 chic09951 chicLY38 chicneo fertile chicEY04675 chick13321 male fertile chic07886 male semi-sterile | recessive chic10 chic14 male sterile chic10 chic15 chic37 chicgdh-5Rev male sterile | recessive chic8A chic10 chic11 chic12 chic13 chic13E chic15 chic35A chic37 chic221 chic01320 chicR1 Other Phenotypes Allele axis specification defective | embryonic stage 15 chic221 axis specification defective | embryonic stage 16 chic221 axis specification defective | embryonic stage 17 chic221 cytokinesis defective | male chicunspecified neuroanatomy defective, with Scer\GAL4P2.4.Pdf chicScer\UAS.cCa neuroanatomy defective | embryonic stage chic221 chicgdh-5 chicsand-1 neuroanatomy defective | somatic clone chic05205a neuroanatomy defective | somatic clone | third instar larval stage chicG1338 visible | recessive chic8A chic13E chic37 chic01320 chicR1 Phenotype manifest in Allele actin filament & eye disc | somatic clone chic221 adult abdomen, with Scer\GAL4esg-NP5130 chicScer\UAS.cCa adult mushroom body | somatic clone chic05205a anterior embryonic/larval midgut | embryonic stage 15 chic221 anterior embryonic/larval midgut | embryonic stage 16 chic221 anterior embryonic/larval midgut | embryonic stage 17 chic221 aster & meiotic cell cycle | male chic01320 chic13E chic35A chic37 chic8A chicR1 border follicle cell chic221 border follicle cell (with chic221) chic01320 border follicle cell (with chic01320) chic221 chick13321 border follicle cell (with chick13321) chic01320 chorion | maternal effect chic01320 cleavage furrow & spermatocyte chic13E contractile ring & meiotic cell cycle | male chic35A chicR1 crossvein | ectopic chic221 chicgdh-5 chicgdh-5Rev cyst cell chic37 dorsal appendage chic01320 chic07886 dorsal appendage | maternal effect chic01320 egg chic01320 chicsand-1 egg chamber chic01320 chic07886 chic11 embryonic/first instar larval cuticle | dorsal chic221 embryonic/larval neuron chic05205a embryonic dorsal epidermis chic221 embryonic leading edge cell chic221 embryonic proventriculus | embryonic stage 15 chic221 embryonic proventriculus | embryonic stage 16 chic221 embryonic proventriculus | embryonic stage 17 chic221 embryonic somatic muscle chic221 filopodium (with chic221) chic05205a filopodium (with chic05205a) chic221 filopodium (with Df(2L)GpdhA) chic05205a chic221 follicle cell & actin filament | somatic clone chic05205a germarium chic37 histoblast nest, with Scer\GAL4esg-NP5130 chicScer\UAS.cCa intersegmental nerve chic05205a chic221 chicgdh-5 chicsand-1 karyosome chic01320 chic11 LNv neuron, with Scer\GAL4P2.4.Pdf chicScer\UAS.cCa longitudinal connective chic221 chicsand-1 longitudinal connective (with chic221) chic05205a longitudinal connective (with chic05205a) chic221 macrochaeta chic01320 chic13E chic37 chic8A chicR1 chicScer\UAS.cJa meiotic cell cycle chicunspecified microchaeta chic37 morphogenetic furrow | somatic clone chic221 motor neuron (with Df(2L)GpdhA) chic05205a chic221 motor neuron | embryonic stage chicsand-1 Nebenkern chicunspecified nurse cell chic01320 chic04612 chic06356 chic07886 chic09951 chic1 chic2 chic221 chicLY38 chicneo nurse cell ring canal chic01320 chic07886 onion stage spermatid chic01320 chic13E chic35A chic37 chic8A chicR1 oocyte chic1 chic11 photoreceptor cell & eye disc | somatic clone chic221 secondary spermatocyte chicR1 spermatid chicunspecified spermatocyte chic35A spermatocyte ring canal chicunspecified spindle & meiotic cell cycle | male chic13E chic35A chicR1 stage S8 oocyte chic221 stage S8 oocyte | maternal effect chic01320 sternopleural bristle chic37 testis chic10 chic11 chic12 chic13 chic14 chic15 chic37 trichogen cell & actin filament & pupa chicScer\UAS.cJa ventral adult lateral neuron & commissure, with Scer\GAL4P2.4.Pdf chicScer\UAS.cCa wing chic221 chicgdh-5Rev
Classical Alleles ( 55 )
For All Classical Alleles Show
Allele of chic Class Mutagen Stocks Known lesion chic221 amorphic allele - genetic evidence Delta2-3 2 Yes chic01320 loss of function allele P-element activity 2 Yes chick13321 P-element activity 2 Yes chicNP7317 2 -- chic5-HA-1239 1 -- chic5-HA-1711 1 -- chic5-HA-1942 1 -- chicd02862 P-element activity 1 -- chicd11232 P-element activity 1 -- chicEY04675 P-element activity 1 -- chicEY13121 P-element activity 1 -- chic281 amorphic allele - genetic evidence Delta2-3 0 Yes chic04612 P-element activity 0 Yes chic05205a P-element activity 0 Yes chic06356 P-element activity 0 Yes chic07886 P-element activity 0 Yes chic09951 P-element activity 0 Yes chic103 Delta2-3 0 -- chic10 hypomorphic allele - genetic evidence P-element activity 0 -- chic11 hypomorphic allele - genetic evidence P-element activity 0 -- chic12 hypomorphic allele - genetic evidence P-element activity 0 -- chic139 Delta2-3 0 -- chic13 hypomorphic allele - genetic evidence P-element activity 0 -- chic13E P-element activity 0 Yes chic14 hypomorphic allele - genetic evidence P-element activity 0 -- chic15 hypomorphic allele - genetic evidence P-element activity 0 -- chic1 ethyl methanesulfonate 0 -- chic211 Delta2-3 0 -- chic2 ethyl methanesulfonate 0 -- chic321 Delta2-3 0 -- chic35A P-element activity 0 Yes chic37 Delta2-3 0 Yes chic38 Delta2-3 0 -- chic3 ethyl methanesulfonate 0 -- chic8A P-element activity 0 Yes chicd10283 P-element activity 0 -- chicEP1011 P-element activity 0 Yes chicEP1095 P-element activity 0 -- chicEP2216 P-element activity 0 -- chicEP397 P-element activity 0 -- chicEP713 P-element activity 0 -- chicG1338 ethyl methanesulfonate 0 Yes chicgdh-5 antimorphic allele - genetic evidence 0 -- chicgdh-5Rev 0 -- chicGS-A2665 Delta2-3 0 -- chicGS9655 0 -- chick02707 P-element activity 0 -- chicLY38 P-element activity 0 Yes chicneo P-element activity 0 Yes chicNP4726 0 -- chicR1 P-element activity 0 Yes chicsand-1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- chicsand-2 ethyl methanesulfonate 0 -- chicUC57 0 -- chicunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of chic Class Mutagen Stocks Known lesion chicY126R.otu in vitro construct - regulatory fusion in vitro construct - amino acid replacement 2 Yes chicHMS00550 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chicKK112358 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chicotu.PW in vitro construct - regulatory fusion 1 Yes chicY120H.otu in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes chicY126Q.otu in vitro construct - regulatory fusion in vitro construct - amino acid replacement 1 Yes chicdsRNA.139-704 in vitro construct - RNAi 0 Yes chicGD4687 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes chicMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes chicScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes chicScer\UAS.cJa in vitro construct - regulatory fusion 0 Yes chicScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC353 (Christensen et al., 2007.10.29) Df(2L)chic-106 (Verheyen and Cooley, 1994) Df(2L)chic-112 (Verheyen and Cooley, 1994) Df(2L)chic-129 (Verheyen and Cooley, 1994) Df(2L)cl-h3 (Wills et al., 1999, van Vactor et al., 1993) Df(2L)GpdhA (Giansanti et al., 1998, Wills et al., 1999, Spradling et al., 1999, Castrillon et al., 1993, BDGP Project Members, 1994-1999) Dp(2;2)C619 (Reeve et al., 2005)
Not disrupted in	Df(2L)ade2-3 (BDGP Project Members, 1994-1999) Df(2L)cl7 (Giansanti et al., 1998, Wills et al., 1999)
Duplicated in	Df(2L)BSC168 (Christensen and Cook, 2006.8.29) Dp(2;2)C619 (Wills et al., 1999, Doberstein et al., 1995, Doberstein et al., 1994)
Partially disrupted in	Df(2L)chic38 (Verheyen and Cooley, 1994) Df(2L)chic103 (Verheyen and Cooley, 1994) Df(2L)chic139 (Verheyen and Cooley, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4687} NA P{KK112358} NA P{TRiP.HMS00550} NA P{UAS-chic.C} NA P{UAS-chic.J} NA P{UAS-EGFP-chic} NA characterization construct P{otu-chic.W} NA P{otu-chic.Y120H} NA P{otu-chic.Y126Q} NA P{otu-chic.Y126R} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}chicEP397 NA P{EP}chicEP713 NA P{EP}chicEP1095 NA P{EP}chicEP2216 NA P{EP}eIF-4aEP1011 NA P{EPgy2}chicEY04675 NA P{EPgy2}chicEY13121 NA P{GSV1}C174C174 NA P{GSV1}chicGS-A2665 NA P{GSV6}chicGS9655 NA P{XP}chicd02862 NA P{XP}chicd10283 NA P{XP}chicd11232 NA P{XP}chicd11344 NA insertion of enhancer trap P{A92}chic11 No P{lacW}chic8A No P{lacW}chic13E No P{lacW}chic35A No P{lacW}chick02707 No P{lacW}chick13321 No P{lacW}chicR1 No P{lacW}l(2)SH0412SH0412 No P{PZ}chic10 No P{PZ}chic12 No P{PZ}chic13 No P{PZ}chic14 No P{PZ}chic15 No P{PZ}chic103 No P{PZ}chic01320 No P{PZ}chic04612 No P{PZ}chic05205a No P{PZ}chic06356 No P{PZ}chic07886 No P{PZ}chic09951 No miscellaneous insertions P{hsneo}chicneo NA P{RS5}chic5-HA-1239 NA P{RS5}chic5-HA-1711 NA P{RS5}chic5-HA-1942 NA P{ry11}chicLY38 NA insertion of enhancer trap binary system P{GawB}chicNP4726 No P{GawB}chicNP7317 No
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with dia (Webb et al., 2009) inferred from physical interaction with UniProtKB:Q8T4F7 (assigned by UniProtKB) (Ahern-Djamali et al., 1999)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Baum and Perrimon, 2001) axon guidance inferred from mutant phenotype (Berger et al., 2008) brain development inferred from genetic interaction with cib (Boquet et al., 2000) inferred from mutant phenotype (Reeve et al., 2005) cell morphogenesis inferred from mutant phenotype (Rogers et al., 2003, D'Ambrosio and Vale, 2010) cytokinesis inferred from mutant phenotype (Echard et al., 2004, Dean et al., 2005) histoblast morphogenesis inferred from mutant phenotype (Ninov et al., 2007) karyosome formation inferred from mutant phenotype (Djagaeva et al., 2005) larval central nervous system remodeling inferred from genetic interaction with cib (Boquet et al., 2000) maintenance of protein location in cell inferred from mutant phenotype (Dean et al., 2005) ovarian nurse cell to oocyte transport inferred from mutant phenotype (Schupbach and Wieschaus, 1991) positive regulation of filopodium assembly inferred from mutant phenotype (Gonçalves-Pimentel et al., 2011) spermatogenesis inferred from mutant phenotype (Castrillon et al., 1993)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR002097, InterPro:IPR005455 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) phosphatidylinositol-4,5-bisphosphate binding non-traceable author statement (Swiss-Prot Project Members, 1992.5.1)
Biological Process
CV term Evidence References
actin filament organization traceable author statement (Buszczak and Cooley, 2000) actin filament polymerization traceable author statement (Harden, 2002) actin polymerization or depolymerization non-traceable author statement (Swiss-Prot Project Members, 1992.5.1) cytokinesis, actomyosin contractile ring assembly traceable author statement (Mazumdar and Mazumdar, 2002) dorsal closure traceable author statement (Van Aelst and Symons, 2002, Harden, 2002, Martin and Wood, 2002) pole plasm oskar mRNA localization traceable author statement (Johnstone and Lasko, 2001)
Cellular Component
CV term Evidence References
actin cytoskeleton inferred from electronic annotation with InterPro:IPR002097 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions chic allele Gene References chic10 CycB (Ji et al., 2002) chic11 peb (Wilk et al., 2004) chic13 CycB (Ji et al., 2002) chic14 CycB (Ji et al., 2002) chic15 CycB (Ji et al., 2002) chic221 Abl (Wills et al., 1999) cib (Boquet et al., 2000) peb (Wilk et al., 2004) th (Geisbrecht and Montell, 2004) chic01320 capu (Manseau et al., 1996) peb (Wilk et al., 2004) S (Gaengel and Mlodzik, 2003) th (Geisbrecht and Montell, 2004) chic05205a Abl (Wills et al., 1999) capt (Baum and Perrimon, 2001) chic07886 CycB (Ji et al., 2002) Ras85D (Schnorr et al., 2001) chick13321 peb (Wilk et al., 2004) Ras85D (Schnorr et al., 2001) th (Geisbrecht and Montell, 2004) chicsand-1 Cdc42 (Fritz and VanBerkum, 2002) Rac1 (Fritz and VanBerkum, 2002) chicScer\UAS.cCa Rac1 (Geisbrecht and Montell, 2004) unspecified Btk29A (Chandrasekaran and Beckendorf, 2005) ct (Krupp et al., 2005) Fmr1 (Reeve et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59999 DroID - A comprehensive database of gene and protein interactions. • FBgn0000308 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33834
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14290 Dere\GG24265 Dgri\GH10716 Dmoj\GI11304 Dper\GL19093 Dpse\GA21874 Dsec\GM17979 Dsim\chic Dvir\GJ12548 Dwil\GK15407 Dyak\GE18963
Curated drosophilid orthologs	Dpse\GA21874   Dsim\chic (Jagadeeshan and Singh, 2005.5.16)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013353-PA Aedes aegypti (mosquito) AGAP009861-PA Anopheles gambiae (mosquito) NP_001011626.1 Apis mellifera (honey bee) XP_001945869.1 Acyrthosiphon pisum (pea aphid) At2g19770.1 Arabidopsis thaliana (wall cress) 14302 Batrachochytrium dendrobatidis (chytrid fungus) 278128 Branchiostoma floridae (lancelet) XP_001895778.1 Brugia malayi (roundworm nematode) BGIBMGA002981-PA Bombyx mori (silk worm) ENSBTAP00000004412 Bos taurus (bovine) CAL0001759 Candida albicans (a form of yeast) CN08828 Caenorhabditis brenneri (small nematode) CBP37364 Caenorhabditis briggsae (nematode) CE07332 Caenorhabditis elegans (worm) ENSCAFP00000005900 Canis familiaris (dog) CAGL0I01078g Candida glabrata (haploid yeast) JA04155 Caenorhabditis japonica (nematode) CMP220C Cyanidioschyzon merolae (red alga) cn01556 Cryptococcus neoformans (yeast-like fungus) CPIJ001546 Culex pipens (mosquito) ENSCPOP00000008689 Cavia porcellus (guinea pig) 181887 Chlamidomonas reinhardtii (green alga) RP11694 Caenorhabditis remanei (nematode) 217717 Capitella spl (polychaete worm) DDB0191249 Dictyostelium discoideum (amoeba) DEHA2G14784g Debaryomyces Hansenii (yeast) 307555 Daphnia pulex (daphnia) XP_652204 Entamoeba histolytica (anaerobic protozoan) 184858 Hypsipyla robusta (cedar shoot borer) ENSP00000322170 Homo sapiens (human) ISCW023148-PA Ixodes scapularis (deer tick) KLLA0E02289g Kluyveromyces lactis (yeast) 112056 Lottia gigantea (owl limpet) LmjF32.0520 Leishmania major (virus) 35996 Monocosta brevicollis (choanoflagellate) ENSMODP00000002621 Monodelphis domestica (gray opossum) ENSMUSP00000020967 Mus musculus (house mouse) 171063 Nematostella vectensis (starlet anemone) XP_001607402.1 Nasonia vitripennis (wasp) ENSOANP00000012159 Ornithorynchus anatinus (platypus) LOC_Os10g17660.1 Oryza sativa (asian rice) LOC_Os10g17680.1 Oryza sativa (asian rice) PHUM001595-PA Pediculus humanus (human body louse) PP19375 Pristionchus pacificus (nematode) 174045 Physcomitrella patens (moss) 653969 Populus trichocarpa (black cottonwood) ENSPTRP00000020116 Pan troglodytes (chimpanzee) 146500 Sorghum bicolor (sorghum) YOR122C Saccharomyces cerevisiae (budding yeast) SPAC4A8.15c Schizosaccharomyces pombe (fission yeast) NP_999760.1 Strongylocentrotus purpuratus (purple sea urchin) 35180 Trichoplax adhaerens (metazoa) XP_970661.1 Tribolium castaneum (red flour beetle) Tc00.1047053458759.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510911.10 Trypanosoma cruzi (parasitic trypanosome) 85889.m00374 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000033475 Xenopus tropicalis (frog) YALI0B07183g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11139 ISCW023148 FBgn0236333 FBgn0217412 FBgn0199788 FBgn0083419 FBgn0172886 JGI_V11_307555 FBgn0081859 FBgn0156693 FBgn0134065 FBgn0118197 FBgn0116397 FBgn0091317 CPIJ001546 BGIBMGA002981 ACYPI002963 ACYPI002150 GB13380 AGAP009861 AAEL013353 PB24905 PHUM148630 GLEAN_14115
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	4892 chic221 cn1/CyO; ry506 8720 w*; snaSco/CyO; P{otu-chic.Y126Q}7 8721 w*; snaSco/CyO; P{otu-chic.Y120H}3 8719 w*; snaSco/CyO; P{otu-chic.Y126R}2C
Harvard	- P{XP}chicd02862 - P{XP}chicd11232
Kyoto	125159 w1118; P{RS5}chic5-HA-1239 125359 w1118; P{RS5}chic5-HA-1711 125487 w1118; P{RS5}chic5-HA-1942 107932 chic221 cn1/CyO; ry506 107931 chic01320 cn1/CyO; ry506
VDRC	v102759 P{KK112358}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR10M11 BACR48E14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 262 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15851 LD19369 RE52449
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16394 AT26506 GH01306 GH08203 GH08359 GH20581 GH22904 GH24073 GM04991 LD08034 LD17071 LD18814 LD23376 LD30139 LD30282 LD35616 LD47267 LP07627 LP10159 LP10333 LP10433 LP10524 LP14693 LP18065 LP22564 RE02511 RE11729 RE14190 RE14506 RE15230 RE17506 RE19763 RE26647 RE30813 RE30850 RE32182 RE37160 RE38665 RE43422 RE44018 RE44051 RE45007 RE45243 RE46149 RE50570 RE51659 RE52261 RE57982 RE58615 RE61808 RE64876 RE65377 RE67559 RE68945 RE69423 RE70615 RE71022 RE71405 RE71915 RE73872 RH03479 RH03750 RH03960 RH04185 RH19049 RH21332 RH21522 RH23219 RH23449 RH25083 RH27371 RH28461 RH29055 RH29321 RH30036 RH30292 RH32962 RH34295 RH35616 RH36034 RH36082 RH36184 RH38796 RH39801 RH41682 RH44342 RH45028 RH45288 RH49346 RH49782 RH50654 RH52886 RH56593 RH56758 RH57871 RH63279 RH68433 RH68913 SD05393 SD17464 SD19812
Other clones	106188 190421 274693 522397 522535 523184 523686 523968 524261 524996 525002 525026 528190 528274 528325 533833 542462 542837 569573 569743 569786 571219 571329 571330 CK01.72C.A10 CK01.89B.F11 Dmel_dig_004594_0655_1742 Dmel_neb_016409_0827_3316 EC00504 EC01504 EC01890 EC13561 EC22010 EC25283 EC25683 EC30821 EC39204 EC39489 EK033304 EK034330 EK043310 EK057533 EK070218 EK074339 EK105517 EK113506 EK175123 EK181746 EK189557 EK191502 EK209325 EK253148 EK292632 EK302533 EN00508 EN01603 EN01944 EN02324 EN02601 EN02839 EN03557 EN04115 EN04527 EN05008 EN05042 EN05344 EN05732 EN06017 EN06050 EN06325 EN06356 EN08108 EN09022 EN09352 EN09450 EN10241 EN10323 EN10650 EN11408 EN11440 EN11508 EN11716 EN12550 EN13008 EN15518 EN15619 EN16351 EN16633 ESG014c.E21_C02 ESG016d.E21_F01 ESG0113b.B21.1_D12 FGC015B02 FGC032A12 FGH122B09 FGM101B04 FGM222D01 FGM233F09 FGM303A03 FGM307G01 FGM309H02 FGM314H02 LD11782 LP24072 RH09028 RP004083036 RP004101565 RP004129422 RP004135973 RP004165991 RP004172076 RP004185560 RP004187966 RP004196265 RP004196842 RP004204751 RP004221139 RP004224104 RP004224552 RP004239506 RP004243104 RP004246374 RP004248635 RP004253520 RP004253539 RP004261217 RP004313449 RP004320167 RP004331064 RP004355068 RP004362425 RP004379201 RP004395005 RP004400359 RP004401099 RP004425915 RP004429398 RP004436753 RP004442195 RP004447977 RP004452189 RP004496150 RP004498495 RP004504918 RP004515227 RP004517071 RP004522912 RP004523966 RP004525022 RP004531758 RP004534363 RP004534899 RP004536317 RP004542734 RP004545034 RP004546003 RP004549220 RP004559977 UUGC0690
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000308 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33834
Antibody Information
	monoclonal (Verheyen and Cooley, 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum. (Philips et al., 2005) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003) chic regulates actin filament formation throughout the cell cortex in the follicular epithelium. (Baum and Perrimon, 2001) cib and chic cooperate in central brain metamorphosis. (Boquet et al., 2000) ena protein can bind directly to chic protein. The proline-rich region of ena is responsible for this interaction. (Ahern-Djamali et al., 1999) Mutations in chic disrupt cytokinesis during male meiosis, preventing the formation of both the central spindle and the contractile ring. (Giansanti et al., 1998) Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell dysregulation. (Braun et al., 1997) The chic mutant phenotype resembles that caused by disrupting the actin cytoskeleton with cytochalasin D, and that of capu and spir. Mutants in chic resemble those in capu in that they fail to localize stau protein and osk mRNA to the posterior pole of the developing oocyte. (Manseau et al., 1996) The chic profilin product can bind to the product of capu in a yeast two hybrid assay. (Manseau et al., 1996) Phenotypic analysis of chic male-sterile alleles reveals defects in meiotic cytokinesis and suggests that proper actin assembly is necessary for centrosome separation and migration. (Giansanti et al., 1995) Induced expression of chic proteins causes aberrant cell shapes reflecting defects in cytokinesis and/or cel shape maintenance. (Edwards et al., 1994) Proliferation defect locus. (Castrillon et al., 1993) Identification: Screen for mutations affecting neuromuscular connectivity, using an antibody to Fas2. (van Vactor et al., 1993) The network of cytoplasmic actin filaments in each nurse cell is missing in chic egg chambers: this does not account for the chic phenotype. Cytoplasm transport is disrupted as nuclei are not properly held in position during chic nurse cell regression and when flow starts the nuclei are pushed into the ring canals thus blocking the pathway to the oocyte. (Cooley et al., 1992) There are at least 10 P element insertions at chic with effects on both male and female fertility and bristle formation. Female sterile mutation caused by loss of ovary specific transcript. P insert in first exon. (Cooley et al., 1992) Promotes actin assembly. (Cooley et al., 1992) Mutations at the chic locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057668 NM_134304 NM_164667 NM_205913 RefSeq (Proteins) • NP_477016 NP_599131 NP_723136 NP_995635 DDBJ / EMBL / GenBank • AA264383 AA441071 AA540038 AAA28418 AAA28419 AAF52315 AAF52316 AAL39589 AAM75036 AAN10565 AAS64643 AAY56643 AC004268 AC004758 AC092239 AQ025026 AQ025993 AQ026056 AQ026482 AQ073404 AQ254819 AW942382 AY069444 AY128443 CL632151 CW848232 CZ473038 CZ477197 CZ477632 DQ062770 M84528 M84529 Entrez Gene - A searchable database of RefSeq genes. • 33834 UniProtKB/Swiss-Prot • P25843
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Profilin/allergen (IPR002097) Profilin, plant (IPR005455)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59999 DroID - A comprehensive database of gene and protein interactions. • FBgn0000308 DRSC - Results from RNAi screens. • FBgn0000308 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000308 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9553-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000308 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33834 InParanoid A subset of ortholog calls from InParanoid. • AAEL013353-PA Aedes aegypti (mosquito) AGAP009861-PA Anopheles gambiae (mosquito) NP_001011626.1 Apis mellifera (honey bee) XP_001945869.1 Acyrthosiphon pisum (pea aphid) At2g19770.1 Arabidopsis thaliana (wall cress) 14302 Batrachochytrium dendrobatidis (chytrid fungus) 278128 Branchiostoma floridae (lancelet) XP_001895778.1 Brugia malayi (roundworm nematode) BGIBMGA002981-PA Bombyx mori (silk worm) ENSBTAP00000004412 Bos taurus (bovine) CAL0001759 Candida albicans (a form of yeast) CN08828 Caenorhabditis brenneri (small nematode) CBP37364 Caenorhabditis briggsae (nematode) CE07332 Caenorhabditis elegans (worm) ENSCAFP00000005900 Canis familiaris (dog) CAGL0I01078g Candida glabrata (haploid yeast) JA04155 Caenorhabditis japonica (nematode) CMP220C Cyanidioschyzon merolae (red alga) cn01556 Cryptococcus neoformans (yeast-like fungus) CPIJ001546 Culex pipens (mosquito) ENSCPOP00000008689 Cavia porcellus (guinea pig) 181887 Chlamidomonas reinhardtii (green alga) RP11694 Caenorhabditis remanei (nematode) 217717 Capitella spl (polychaete worm) DDB0191249 Dictyostelium discoideum (amoeba) DEHA2G14784g Debaryomyces Hansenii (yeast) 307555 Daphnia pulex (daphnia) XP_652204 Entamoeba histolytica (anaerobic protozoan) 184858 Hypsipyla robusta (cedar shoot borer) ENSP00000322170 Homo sapiens (human) ISCW023148-PA Ixodes scapularis (deer tick) KLLA0E02289g Kluyveromyces lactis (yeast) 112056 Lottia gigantea (owl limpet) LmjF32.0520 Leishmania major (virus) 35996 Monocosta brevicollis (choanoflagellate) ENSMODP00000002621 Monodelphis domestica (gray opossum) ENSMUSP00000020967 Mus musculus (house mouse) 171063 Nematostella vectensis (starlet anemone) XP_001607402.1 Nasonia vitripennis (wasp) ENSOANP00000012159 Ornithorynchus anatinus (platypus) LOC_Os10g17660.1 Oryza sativa (asian rice) LOC_Os10g17680.1 Oryza sativa (asian rice) PHUM001595-PA Pediculus humanus (human body louse) PP19375 Pristionchus pacificus (nematode) 174045 Physcomitrella patens (moss) 653969 Populus trichocarpa (black cottonwood) ENSPTRP00000020116 Pan troglodytes (chimpanzee) 146500 Sorghum bicolor (sorghum) YOR122C Saccharomyces cerevisiae (budding yeast) SPAC4A8.15c Schizosaccharomyces pombe (fission yeast) NP_999760.1 Strongylocentrotus purpuratus (purple sea urchin) 35180 Trichoplax adhaerens (metazoa) XP_970661.1 Tribolium castaneum (red flour beetle) Tc00.1047053458759.10 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510911.10 Trypanosoma cruzi (parasitic trypanosome) 85889.m00374 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000033475 Xenopus tropicalis (frog) YALI0B07183g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/chickd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33834 modMine - Data generated by the modENCODE project. • FBgn0000308 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11139 ISCW023148 FBgn0236333 FBgn0217412 FBgn0199788 FBgn0083419 FBgn0172886 JGI_V11_307555 FBgn0081859 FBgn0156693 FBgn0134065 FBgn0118197 FBgn0116397 FBgn0091317 CPIJ001546 BGIBMGA002981 ACYPI002963 ACYPI002150 GB13380 AGAP009861 AAEL013353 PB24905 PHUM148630 GLEAN_14115
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG9553 (Goldstein and Gunawardena, 2000, Rogers et al., 2003, Quinones-Coello, 2007, Molnar et al., 2006, Jagadeeshan and Singh, 2005, Keleman et al., 2009.8.5, Berger et al., 2008, Ni et al., 2010.12.1, Cammarato et al., 2011) Chi (Oh et al., 2003) chi (Spradling et al., 1999, ) Chic (Mazumdar and Mazumdar, 2002, Deshpande et al., 2006, Lee et al., 2007, Johnson et al., 2008, Webb et al., 2009) chic (Oshima, 2006, Christensen and Cook, 2006.8.29, Wang and Riechmann, 2007, Stuart et al., 2007, Montana and Littleton, 2006, Neuman-Silberberg, 2007, Christensen et al., 2007.10.29, Quinones-Coello, 2007, Ninov et al., 2007, Molnar et al., 2006, Jagadeeshan and Singh, 2005, Wang and Riechmann, 2008, Kim et al., 2001, Dahlgaard et al., 2007, Dyer et al., 2007, Frank et al., 2006, Noguchi et al., 2008, Pawson et al., 2008, Matusek et al., 2008, Minakhina et al., 2005, Parrish et al., 2007, Franciscovich et al., 2008, Maybeck and Röper, 2009, Dworkin et al., 2009, Warner and Longmore, 2009, Johnson et al., 2008, Burnett et al., 2008, Sánchez-Soriano et al., 2010, Okumura et al., 2010, Wang et al., 2010, Corrigall et al., 2007, Barkó et al., 2010, Seong et al., 2011, Gonçalves-Pimentel et al., 2011, Cunha et al., 2010) chickadee (Staudt et al., 2005) D88 (Edwards et al., 1994) GH4 (Jagadeeshan and Singh, 2005) l(2)27/7 (Braun et al., 1997) profilin (Rogers et al., 2003) sand (Schneider and Granato, 2003, Seeger, 1994, van Vactor et al., 1993, )
Name Synonym	chickaddee (Rogers et al., 2003) chickadee (Chanut-Delalande et al., 2006, Cooley, 1994.6.22, Schubiger et al., 1997, Hoopfer et al., 2008, Neuman-Silberberg, 2007, Wu et al., 2008, Estes et al., 2008, Wang and Riechmann, 2008, Dean et al., 2005, Staudt et al., 2005, Lee et al., 2007, Corrigall et al., 2007, Dyer et al., 2007, Tanaka and Nakamura, 2008, Tessier and Broadie, 2008, Frank et al., 2006, Muraro and Moffat, 2006, Minakhina et al., 2005, Maybeck and Röper, 2009, Berger et al., 2008, Burnett et al., 2008, Sánchez-Soriano et al., 2010, Okumura et al., 2010, Suganuma et al., 2010, Cammarato et al., 2011) Chickadee (Johnson et al., 2008, Webb et al., 2009) DProfilin (Pichaud et al., 2007) profilin (Wear and Cooper, 2004, Fernandez, 2004, Frank et al., 2004, Acebes and Ferrus, 2000, Baum, 2002, Petit et al., 2002, Hopmann and Miller, 2002, Hopmann and Miller, 2001, Anonymous, 2001, Anonymous, 2001, Lin and Greenberg, 2000, Treisman et al., 2000, Saffman and Lasko, 1999, Beitel and Krasnow, 1998, Geisbrecht and Montell, 2004, Sokol and Cooley, 2003, Talbot and VanBerkum, 2006, Prokopenko and Chia, 2008, Starr and Han, 2003, Baum and Kunda, 2005, D'Avino et al., 2005, Martin et al., 2005, Kim et al., 2001, Corrigall et al., 2007, Johnson et al., 2008, Tanaka and Nakamura, 2008, Tessier and Broadie, 2008, Frank et al., 2006, Webb et al., 2009, Sánchez-Soriano et al., 2010, Barkó et al., 2010) Profilin (Jacinto and Baum, 2003, Wills et al., 2002, Zhang and Kalderon, 2001, Matova and Cooley, 2001, Van Berkum et al., 2001, Baum et al., 2000, Gallo and Letourneau, 1999, Spradling et al., 1997, Adrain et al., 2004, Bergmann, 2006, Rogers et al., 2003, Pimentel et al., 2007, Ninov et al., 2007, Serio et al., 2010, D'Ambrosio and Vale, 2010) stranded (van Vactor et al., 1993, )
Secondary FlyBase IDs
	FBgn0013731
References ( 250 )
Generate a list of	All references relating to this gene ( 250 )
List References by type	Research paper  ( 111 ) Supplementary material  ( 10 ) Review  ( 58 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 48 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 10 )
	Gonçalves-Pimentel et al., 2011, PLoS ONE 6(3): e18340 Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. [FBrf0213367] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Barkó et al., 2010, J. Biol. Chem. 285(17): 13154--13169 Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM. [FBrf0210590] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] D'Ambrosio and Vale, 2010, J. Cell Biol. 191(3): 471--478 A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. [FBrf0212211] Okumura et al., 2010, Dev. Biol. 344(2): 693--706 Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila. [FBrf0211383] Serio et al., 2010, Cell Host Microbe 7(5): 388--398 Defining a Core Set of Actin Cytoskeletal Proteins Critical for Actin-Based Motility of Rickettsia. [FBrf0210774] Suganuma et al., 2010, Cell 142(5): 726--736 The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. [FBrf0214172] Sánchez-Soriano et al., 2010, Dev. Neurobiol. 70(1): 58--71 Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics. [FBrf0209638] Wang et al., 2010, J. Cell Sci. 123(9): 1546--1556 Drosophila twinfilin is required for cell migration and synaptic endocytosis. [FBrf0210650] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...