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Gene Dmel\chp

General Information
Symbol	Dmel\chp	Species	D. melanogaster
Name	chaoptic	Annotation symbol	CG1744
Feature type	protein_coding_gene	FlyBase ID	FBgn0000313
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	24B10, Mab24B10, MAb 24B10, 516
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100B5-100B6	Sequence location	3R:27,029,902..27,036,452 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene chaoptic is referred to in FlyBase by the symbol Dmel\chp (CG1744, FBgn0000313). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: rhabdomere development; homophilic cell adhesion. 16 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; rhabdomere. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Armadillo; Leucine-rich repeat; Leucine-rich repeat, typical subtype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1636344_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of chp. Gene sequence location is 3R:27029902..27036452.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	chp: chaoptic The structural gene encoding chaoptin, a 160 kd glycoprotein localized to the extracellular membrane surface of photoreceptor cells and their axonal projections to the optic ganglia. Protein first identified by a monoclonal antibody (MAb24B10). Antigen first appears behind the morphogenetic furrow during differentiation of the eye imaginal disk. Defective alleles, chp1 and chp2, recognized by reduced levels of antigen. Rhabdomeres of mutant photoreceptor cells highly deranged or nearly absent in homozygotes and hemizygotes for chp1 or chp2, respectively; also close apposition of adjacent retinular cells partially disrupted. Gene product postulated to play role in cell surface interactions necessary for correct alignment of the microvilli that form the rhabdomeres.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100B5-100B6   Limits computationally determined from genome sequence between P{PZ}Aph-407028&P{PZ}dcorK215 and P{PZ}l(3)rM731rM731
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100B-100B   (determined by in situ hybridisation)   (Levy et al., 1982)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\chp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.47 DGC clone HL03177 appears problematic: incomplete CDS; large gene with no complete cDNAs gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) chp-RA FBtr0085778  NM_079866   4872   1315 chp-RC FBtr0330100  NM_001276207   4842   1305 chp-RD FBtr0330101  NM_001276208   4863   1338 chp-RE FBtr0335410  NM_001276205   4851   1308 chp-RF FBtr0335411  NM_001276206   4863   1312
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein chp-PA   FBpp0085139   152.0   1315   6.80     NP_524605   AAF57127 chp-PC   FBpp0303133   150.7   1305   6.80     NP_001263136   AGB96515 chp-PD   FBpp0303134   154.7   1338   6.81     NP_001263137   AGB96516 chp-PE   FBpp0307393   151.1   1308   6.80     NP_001263134   AGB96513 chp-PF   FBpp0307394   151.6   1312   6.80     NP_001263135   AGB96514
Additional Polypeptide Data & Comments
Reported size (kDa)	165, 160 (kD) (Krantz and Zipursky, 1990) 160 (kD) (Pollock et al., 1990)
Comments	Expression of a hsp70 promoter driven chp cDNA in S2 cells was used to show that chp protein encodes a homotypic adhesion molecule. (Krantz and Zipursky, 1990) An intracellular precursor to the 160kD form of chp protein. (Krantz and Zipursky, 1990)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567417   AA567890   AA568035   AA697343   AA697524   AA697583   AA697635   AA697707   AA697743   AA697798   AA698002   AA698211   AA698325   AA698805   AA699151   AE014297 AAF57127   AE014297 AGB96513   AE014297 AGB96514   AE014297 AGB96515   AE014297 AGB96516   AI062918   AI106978   AI107015   AI292645   AI292937   AI387933   AI388679   AI402391   AI404411   AI517502   AY232205   BI564025   BI565026   BI575020   BI575129   BI584562   BI587373   BI588951   BI609658   BI609715   BI611248   BI617986   BI622661   BI627311   BT053753   BT125717   BT125745   BT126010   BT126059   CO268484   CO272703   CO275611   CO276818   CO277000   CO277700   CO280695   CO296812   CO296883   CO308153   CO313715   CO313790   CO319641   CO329803   CO330549   CO332289   CO340928   CO343478   DN154280   EC065303   EC076233   EC079707   EC086216   EC090327   EC197702   EC198695   EC202746   EC208543   EC216614   EC238180   EC243313   EC245257   EC247528   EC253747   K03274 AAA28851   M19008 AAA28425   M19009 AAA28425   M19010 AAA28425   M19011 AAA28425   M19012 AAA28425   M19013 AAA28425   M19014 AAA28425   M19015 AAA28425   M19016 AAA28425   M19017 AAA28425   M19018   M19453
UniProtKB/Swiss-Prot	P12024
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 26037
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage & pupal stage   eye-antennal disc   (Pollock et al., 1990) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) larval stage & pupal stage   retina   (Pollock et al., 1990) photoreceptor cell R1 -- photoreceptor cell R8   (Pollock et al., 1990) third instar larval stage   photoreceptor cell   (Haug-Collet et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage & pupal stage   eye-antennal disc   (Pollock et al., 1990) pupal stage   optic lobe   (Pollock et al., 1990) pupal stage & adult stage   medulla   (Pollock et al., 1990) immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   Bolwig organ   (Rosenbaum et al., 2011) larval stage & pupal stage   photoreceptor cell | presumptive   (Pollock et al., 1990) larval stage -- adult stage   retina   (Pollock et al., 1990) third instar larval stage   photoreceptor cell   • plasma membrane (Rodriguez Moncalvo and Campos, 2005) Bolwig nerve   (Malpel et al., 2002) third instar larval stage -- pupal stage P5   photoreceptor cell | precursor   (Malpel et al., 2002) prepupal stage P1 -- pharate adult stage P15   photoreceptor cell   • neuronal cell body & axon (Gibbs, 2001) pupal stage & adult stage   lamina   (Pollock et al., 1990) adult stage   photoreceptor cell   • plasma membrane of terminal bouton (Hiesinger et al., 2001) eyelet photoreceptor   (Malpel et al., 2002) photoreceptor cell   (Malpel et al., 2002)
Additional Descriptive Data
	chp protein is expressed in photoreceptor cell soma and their axons. (Malpel et al., 2002, Pollock et al., 1990) chp protein is expressed in photoreceptor cell soma and their axons as well as in the optic lobe. Mutants chp1 and chp2 show abnormal distribution of antigen and greatly reduced levels of antigen in some tissues. (Krantz and Zipursky, 1990, Pollock et al., 1990) Expressed specifically on the photoreceptor plasma membrane, strongly labeling the photoreceptor axons. (Rodriguez Moncalvo and Campos, 2005)
Marker for
	photoreceptor cell receptor cell R1..8
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Krantz and Zipursky, 1990, Khanna et al., 2010) rhabdomere inferred from direct assay (Yano et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head    2471.8 Adult Eye    5610.75 Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head  (2471.8) Adult Eye  (5610.75) Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head  (2471.8) Adult Eye  (5610.75) Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head    2471.8 Adult Eye    5610.75 Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head    2471.8 Adult Eye    5610.75 Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head  (2471.8) Adult Eye  (5610.75) Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head  (2471.8) Adult Eye  (5610.75) Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    19.625 Larval Midgut    4.2 Larval Hindgut    5.6 Larval Malpighian Tubules    2.1 Larval Fat Body    6.7 Larval Salivary Gland    5.1 Larval Trachea    133.95 Larval Carcass    4.625 Adult Head    2471.8 Adult Eye    5610.75 Adult Brain    36.9 Adult Thoracic-Abdominal Ganglion    4.1 Adult Crop    4.2 Adult Midgut    2.8 Adult Hindgut    4.7 Adult Malpighian Tubules    4.9 Adult Fat Body    7.3 Adult Salivary Gland    11.3 Adult Heart    8.85 Adult VirginFemale Spermatheca    5.8 Adult InseminatedFemale Spermatheca    9.3 Adult Ovary    1.6 Adult Testis    6.8 Adult Male Accessory Gland    356.3 Adult Carcass    10.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2471.8   NA  Eye    5610.75   NA  Brain    36.9   19.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.1   NA  Crop    4.2   4.2  Midgut    2.8   5.6  Hindgut    4.7   2.1  Malpighian Tubules    4.9   6.7  Fat Body    7.3   5.1  Salivary Gland    no informative data   NA  Heart    8.85   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    5.8   NA  InseminatedFemale Spermatheca    9.3   NA  Ovary    1.6   NA  Testis    6.8   NA  Male Accessory Gland    356.3   4.625  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female    466 head, virgin 4-day female    340 head, virgin 20-day female    220 head, mated 1-day female    357 head, mated 4-day female    306 head, mated 20-day female    162 head, mated 1-day male    609 head, mated 4-day male    558 head, mated 20-day male    405 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8  (30) head, virgin 1-day female  (466) head, virgin 4-day female  (340) head, virgin 20-day female  (220) head, mated 1-day female  (357) head, mated 4-day female  (306) head, mated 20-day female  (162) head, mated 1-day male  (609) head, mated 4-day male  (558) head, mated 20-day male  (405) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female  (466) head, virgin 4-day female  (340) head, virgin 20-day female  (220) head, mated 1-day female  (357) head, mated 4-day female  (306) head, mated 20-day female  (162) head, mated 1-day male  (609) head, mated 4-day male  (558) head, mated 20-day male  (405) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female    466 head, virgin 4-day female    340 head, virgin 20-day female    220 head, mated 1-day female    357 head, mated 4-day female    306 head, mated 20-day female    162 head, mated 1-day male    609 head, mated 4-day male    558 head, mated 20-day male    405 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female    466 head, virgin 4-day female    340 head, virgin 20-day female    220 head, mated 1-day female    357 head, mated 4-day female    306 head, mated 20-day female    162 head, mated 1-day male    609 head, mated 4-day male    558 head, mated 20-day male    405 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8  30 head, virgin 1-day female  (466) head, virgin 4-day female  (340) head, virgin 20-day female  (220) head, mated 1-day female  (357) head, mated 4-day female  (306) head, mated 20-day female  (162) head, mated 1-day male  (609) head, mated 4-day male  (558) head, mated 20-day male  (405) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female  (466) head, virgin 4-day female  (340) head, virgin 20-day female  (220) head, mated 1-day female  (357) head, mated 4-day female  (306) head, mated 20-day female  (162) head, mated 1-day male  (609) head, mated 4-day male  (558) head, mated 20-day male  (405) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    4 central nervous system, pupae P8    30 head, virgin 1-day female    466 head, virgin 4-day female    340 head, virgin 20-day female    220 head, mated 1-day female    357 head, mated 4-day female    306 head, mated 20-day female    162 head, mated 1-day male    609 head, mated 4-day male    558 head, mated 20-day male    405 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    16 carcass, larvae L3 wandering    5 carcass, 1-day adult    0 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP    159 pupae 4d postWPP    115 adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP  (31) pupae 3d postWPP  (159) pupae 4d postWPP  (115) adult male 01day  (81) adult male 05day  (60) adult male 30day  (58) adult female 01day  (39) adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP  (159) pupae 4d postWPP  (115) adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP    159 pupae 4d postWPP    115 adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP    159 pupae 4d postWPP    115 adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP  31 pupae 3d postWPP  (159) pupae 4d postWPP  (115) adult male 01day  (81) adult male 05day  (60) adult male 30day  (58) adult female 01day  (39) adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP  (159) pupae 4d postWPP  115 adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    1 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    3 white prepupae 12hr    9 white prepupae 24hr    15 pupae 2d postWPP    31 pupae 3d postWPP    159 pupae 4d postWPP    115 adult male 01day    81 adult male 05day    60 adult male 30day    58 adult female 01day    39 adult female 05day    13 adult female 30day    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    1 embryonic 1182-4H    2 embryonic GM2    1 embryonic Kc167    1 embryonic S1    2 embryonic S3    6 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    3 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    1 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    3 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    5 tumorous blood cells mbn2    0 ovary fGS/OSS    2 ovary OSC    1 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (41) Paraquat 10 mM 48 hrs, 4-day adult  (47) Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    16 heat shock, 4-day adult    16 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    16 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    41 Paraquat 10 mM 48 hrs, 4-day adult    47 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_00 mE1_20_mRNA_expression_cluster_19
External Data & Images
Linkouts	BDGP expression data • HL03177 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000313 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1744-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for chp Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 chpGD1822 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 chpGD1822 visible chpW11 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 chpGD1822 rhabdomere chp1 chp2 chpW11 chpunspecified
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of chp Class Mutagen Stocks Known lesion chp2 1 -- chpMB05115 1 -- chp1 0 -- chp3 0 -- chp5 0 -- chp6 0 -- chp8 0 -- chpJ1 0 Yes chpunspecified 0 -- chpW11 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of chp Class Mutagen Stocks Known lesion chpGD1822 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chpJF01217 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chpJF01447 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chpKK106906 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chphs.PK in vitro construct - regulatory fusion 0 Yes chpNIG.1744R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)A113 (Schejter and Wieschaus, 1993) Df(3R)chpJ1 (Schejter and Wieschaus, 1993) Df(3R)Exel6218 (Ryder, 2004.4.26) Df(3R)Exel7379 (Ryder, 2004.4.26)
Duplicated in	Dp(3;1)48 (Schejter and Wieschaus, 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1822} NA P{KK106906} NA P{NIG.1744R} NA P{TRiP.JF01217} NA P{TRiP.JF01447} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}chpMB05115 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
homophilic cell adhesion inferred from direct assay (Krantz and Zipursky, 1990) rhabdomere development inferred from genetic interaction with prom (Zelhof et al., 2006)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Krantz and Zipursky, 1990, Khanna et al., 2010) rhabdomere inferred from direct assay (Yano et al., 2012)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
compound eye photoreceptor development non-traceable author statement (Swiss-Prot Project Members, 1989.10.1) homophilic cell adhesion non-traceable author statement (Swiss-Prot Project Members, 1989.10.1)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1989.10.1)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions chp allele Gene References unspecified prom (Zelhof et al., 2006)
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000313 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43690
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZKK5M Dipteran inclusive ortholog search EOG6QFWN5 Insect inclusive ortholog search EOG6NGFGK Arthropod inclusive ortholog search EOG669P8Q Metazoa inclusive ortholog search EOG6S527W
Orthologs in Drosophila Species (EOG6ZKK5M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\chp     Drosophila simulans   Dsim\GD16557 Y   Drosophila sechellia   Dsec\GM12100 Y   Drosophila erecta   Dere\GG11882 Y   Drosophila yakuba   Dyak\chp Y   Drosophila ananassae   Dana\GF16594 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14511 Y   Drosophila persimilis   Dper\GL13952 Y   Drosophila willistoni   Dwil\GK22554 Y   Drosophila virilis   Dvir\GJ10649 Y   Drosophila mojavensis   Dmoj\GI10434 Y   Drosophila grimshawi   Dgri\GH14339 Y
Orthologs in non-Drosophila Dipterans (EOG6QFWN5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008940   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015659   Anopheles gambiae Malaria mosquito  Agam\AGAP000019   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012887
Orthologs in non-Dipteran Insects (EOG6NGFGK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51189   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005470   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH23251   Atta cephalotes Leafcutter ant  Acep\ACEP25322   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12542   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14343   Linepithema humile Argentine ant  Lhum\LH19986   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13699   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13701   Solenopsis invicta Red fire ant  Sinv\SINV10838   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001615   Bombyx mori Silkmoth  Bmor\BGIBMGA006308   Pediculus humanus Human body louse  Phum\PHUM104090   Tribolium castaneum Red flour beetle  Tcas\chp
Orthologs in non-Insect Arthropods (EOG669P8Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\SEPT6   Daphnia pulex Water flea  Dpux\CALHM3
Orthologs in non-Arthropod Metazoa (EOG6S527W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001749gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16557 Drosophila sechellia Dsec\GM12100 Drosophila erecta Dere\GG11882 Drosophila yakuba Dyak\chp Drosophila ananassae Dana\GF16594 Drosophila pseudoobscura pseudoobscura Dpse\GA14511 Drosophila persimilis Dper\GL13952 Drosophila willistoni Dwil\GK22554 Drosophila virilis Dvir\GJ10649 Drosophila mojavensis Dmoj\GI10434 Drosophila grimshawi Dgri\GH14339
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	42251 cu1 chp2 24321 w1118; Mi{ET1}chpMB05115 31276 y1 v1; P{TRiP.JF01217}attP2 31655 y1 v1; P{TRiP.JF01447}attP2
VDRC	v108053 P{KK106906}VIE-260B v7329 w1118; P{GD1822}v7329
Genomic Clones ( 2 )
	BACR11C03 BACR30B13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 78 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20134 RH27614
Other clones	RT10217 RT10219 RT11146 yak-ad_chp
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02292 GH06250 GH06294 GH15591 GH15974 GH19649 GH21607 GH24106 GH28483 HL01153 HL01204 HL01951 HL02283 HL02711 HL02821 HL02911 HL03017 HL03087 HL03177 HL03610 HL03952 HL04282 HL05726 HL07806 RH14468 RH14535 RH17429 RH23805 RH27579 RH28036 RH28403 RH30444 RH34995 RH48487 RH54569 RH62660 RH68587
Other clones	927 17973 41706 65449 79226 102060 107725 107783 153601 192357 214413.65 275546 CK01.116C.D12 CK01.120A.A2 CK01.141D.C2 EK091633 EK108104 EK118041 EK122134 EK122603 EK125858 EK154637 EK208836 EK215219 EK215346 EK233862 EK234063 EK256840 EK279749 EK293909 EK295533 EK303042 EP11601 EP16844 GH18637
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000313 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43690
Antibody Information
	polyclonal (Rosenbaum et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: chp CG1744 (Yao, 1999.11)
Source for database merge of
Additional comments	The "idl-A" complementation probably corresponds to alleles of the "chp" locus; idl-A mutants fail to complement hypomorphic chp alleles for inaD mislocalisation and retinal degeneration. (Sanxaridis and Tsunoda, 2010)
Other Comments
	The biophysical and biochemical characteristics of a synthetic Leu-rich repeat peptide (CRP32) generated from the sequence of one of the repeats found in chp is studied. (Krantz et al., 1991) Biochemical analyses demonstrate that chp is linked to the extracellular surface by covalent attachment to glycosyl-phosphotidylinositol: chp is required for photoreceptor cell morphogenesis. Results suggest that chp and other members of the leucine rich repeat family of proteins define a new class of cell adhesion molecules. (Krantz and Zipursky, 1990) chp mutants have disorganized rhabdomere organization. (Pollock et al., 1990) Identified as a cDNA clone that is expressed at a low frequency in the body but abundantly in the head of the adult. (Levy et al., 1982) Developmental expression pattern of the cDNA clone is examined. (Levy and Manning, 1982) The structural gene encoding chaoptin, a 160kD glycoprotein localized to the extracellular membrane surface of photoreceptor cells and their axonal projections to the optic ganglia. Protein first identified by a monoclonal antibody (MAb24B10). Antigen first appears behind the morphogenetic furrow during differentiation of the eye imaginal disk. Defective alleles, chp1 and chp2, recognized by reduced levels of antigen. Rhabdomeres of mutant photoreceptor cells highly deranged or nearly absent in homozygotes and hemizygotes for chp1 or chp2, respectively; also close apposition of adjacent retinular cells partially disrupted. Gene product postulated to play role in cell surface interactions necessary for correct alignment of the microvilli that form the rhabdomeres.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079866 NM_001276205 NM_001276206 NM_001276207 NM_001276208 RefSeq (Proteins) • NP_524605 NP_001263134 NP_001263135 NP_001263136 NP_001263137 DDBJ / EMBL / GenBank • AA697798 AAA28425 AAA28851 AAF57127 AGB96513 AGB96514 AGB96515 AGB96516 K03274 M19008 M19009 M19010 M19011 M19012 M19013 M19014 M19015 M19016 M19017 M19018 M19453 Entrez Gene - A searchable database of RefSeq genes. • 43690 UniProtKB/Swiss-Prot • P12024
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 26037 InterPro domains - A database of protein families, domains, and functional sites • Armadillo (IPR000225) Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • HL03177
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000313 DRSC - Results from RNAi screens. • FBgn0000313 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000313 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1744-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000313 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43690 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43690 modMine - Data generated by the modENCODE project. • FBgn0000313
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	24B10 (Simpson et al., 2009, Fan et al., 2005, Rodriguez Moncalvo and Campos, 2005, Rawson et al., 2005, Fabian-Fine et al., 2003, Tahayato et al., 2003, Helfrich-Forster et al., 2002, Wernet et al., 2003, Cook et al., 2003, Stowers et al., 2002, Lee et al., 2001, Helfrich-Forster et al., 2001, Hassan et al., 2000, Sun et al., 2000, Rao et al., 2000, Schmucker et al., 2000, Ruan et al., 1999, Iyengar et al., 1999, Ohyama et al., 2006, Prakash et al., 2005, Choe et al., 2006, Mikeladze-Dvali et al., 2005, Babu et al., 2005, Hiesinger et al., 2005, Takaesu et al., 2006, Dermaut et al., 2005, Ohyama et al., 2007, Tian et al., 2013, Murakami et al., 2007, Nicolaï et al., 2010, Millard et al., 2007, Zhang et al., 2007, Zhu et al., 2008, Ting et al., 2011, Shcherbata et al., 2007, Banerjee et al., 2008, Cornbrooks et al., 2007, Edwards and Meinertzhagen, 2009, Xiong et al., 2009, Erclik et al., 2008, Morey et al., 2008, Ludlam et al., 2002, Shinza-Kameda et al., 2006, Tomasi et al., 2008, Hamanaka et al., 2010, Kaminker et al., 2002, Higashi-Kovtun et al., 2010, Malartre et al., 2010, Morante et al., 2011, Tong et al., 2011, Houalla et al., 2010, Morante and Desplan, 2008, Timofeev et al., 2012) 516 (Levy and Manning, 1982, Levy et al., 1982) BSH (Choe et al., 2006) CG1744 (Ellis and Carney, 2009, Keleman et al., 2009.8.5, Ni et al., 2009, Khanna et al., 2010, Ni et al., 2008) Chaoptin (Cope et al., 2002) chp (Yang et al., 2005, Zelhof, 2006, Sprecher et al., 2007, Romero-Calderon et al., 2007, Ellis and Carney, 2009, Jungreis et al., 2011, Ranade et al., 2008, Hirai-Fujita et al., 2008, Ni et al., 2009, Hamanaka et al., 2010, Sanxaridis and Tsunoda, 2010, Xun et al., 2008, Abou Tayoun et al., 2011, Japanese National Institute of Genetics, 2012.5.21) Chp (Beronja et al., 2005, Fichelson et al., 2012, Sprecher et al., 2011, Minidorff et al., 2007, Williamson et al., 2010, Yamamoto-Hino et al., 2010, Keene et al., 2011, Sprecher and Desplan, 2008, Kanie et al., 2009, Wu et al., 2005, Yano et al., 2012, Rosenbaum et al., 2012) CHP (Gibbs, 2001) CT5040 (Hynes and Zhao, 2000) Mab24B10 (Ting et al., 2005, Song et al., 2003, Takemura et al., 2011, Erclik et al., 2008) mAb24B10 (Conder et al., 2004, Babcock et al., 2003, Hummel et al., 2002, Suh et al., 2002, Clandinin et al., 2001, Poeck et al., 2001, Certel and Johnson, 2000, Newsome et al., 2000, Hing et al., 1999, Chotard et al., 2005, Bazigou et al., 2007, Bazigou et al., 2007, Hakeda-Suzuki et al., 2011, Takemura et al., 2011, Mast et al., 2008, Morey et al., 2008) MAb 24B10 (Ruan et al., 2002, Newsome et al., 2000) mAb 24B10 (Maurel-Zaffran et al., 2001, Garcia-Alonso, 1999) MAb24B10 (Senti et al., 2000, Chang et al., 2006) mAB24B10 (Weake et al., 2008) Nsp
Name Synonym	chaoptic (Sprecher et al., 2007, Hirai-Fujita et al., 2008, Ni et al., 2009, Sanxaridis and Tsunoda, 2010) Chaoptic (Khanna et al., 2010) Chaoptin (Swanson et al., 2009, Hiesinger et al., 2001, Schau et al., 1999, Warrick et al., 1998, Schmucker et al., 1997, Koushika et al., 1996, Wolfgang et al., 1990, Tayler et al., 2004, Stowers et al., 2002, Long et al., 2006, Beronja et al., 2005, Moses, 2006, Husain et al., 2006, Hassan et al., 2005, Takemura et al., 2011, Fichelson et al., 2012, Zelhof et al., 2003, Xiong and Rebay, 2011, Pramatarova et al., 2006, Abou Tayoun et al., 2011, Sprecher et al., 2011, Minidorff et al., 2007, Williamson et al., 2010, Yamamoto-Hino et al., 2010, Gontang et al., 2011, Rosenbaum et al., 2006, Miller et al., 2008, Morante and Desplan, 2008, Popova et al., 2011, Edwards and Meinertzhagen, 2009, Petrovic and Hummel, 2008, Giagtzoglou et al., 2009, Kanie et al., 2009, Zhang et al., 2009, Berger et al., 2008, Reddy et al., 2010, Malartre et al., 2010, Albornoz et al., 2008, Tong et al., 2011, Hasegawa et al., 2011, Dimitroff et al., 2012, Yano et al., 2012, Stephan et al., 2011) chaoptin (Gorska-Andrzejak et al., 2003, Simpson et al., 2009, Malpel et al., 2002, McNabb and Truman, 2001, Su et al., 2000, Matsumoto and Komori, 1999, Scott and Zuker, 1998, Gibbs and Truman, 1998, Claudianos and Campbell, 1995, Hortsch and Bieber, 1991, Acharya et al., 2004, Cook et al., 2003, Zelhof et al., 2006, Mehta et al., 2005, Banerjee et al., 2008, Xiong et al., 2009, Berni et al., 2008, Gibbs, 2001, Wagner et al., 2007, Hamanaka et al., 2010, Higashi-Kovtun et al., 2010, Vandenborre et al., 2010, Wu et al., 2005, Williamson et al., 2010, Rosenbaum et al., 2011, Kametaka et al., 2012, Rosenbaum et al., 2012) Neural-specific-protein
Secondary FlyBase IDs
References ( 225 )
Generate a list of	All references relating to this gene ( 225 )
List References by type	Research paper  ( 180 ) Supplementary material  ( 12 ) Review  ( 11 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 1 ) Letter  ( 1 )
Recent research papers ( 22 )
	Tian et al., 2013, Neuron 77(2): 311--322 Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. [FBrf0220614] Dimitroff et al., 2012, PLoS ONE 7(2): e30722 Diet and Energy-Sensing Inputs Affect TorC1-Mediated Axon Misrouting but Not TorC2-Directed Synapse Growth in a Drosophila Model of Tuberous Sclerosis. [FBrf0217461] Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898 Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313] Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589] Rosenbaum et al., 2012, Vis. Neurosci. 29(3): 143--156 Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin. [FBrf0218440] Timofeev et al., 2012, Neuron 75(1): 80--93 Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila. [FBrf0218874] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Abou Tayoun et al., 2011, J. Neurosci. 31(39): 13897--13910 The Drosophila SK Channel (dSK) Contributes to Photoreceptor Performance by Mediating Sensitivity Control at the First Visual Network. [FBrf0216279] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Gontang et al., 2011, Development 138(22): 4899--4909 The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system. [FBrf0216508] Hakeda-Suzuki et al., 2011, Nat. Neurosci. 14(3): 314--323 Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. [FBrf0213128] Hasegawa et al., 2011, Development 138(5): 983--993 Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. [FBrf0213020] Keene et al., 2011, J. Neurosci. 31(17): 6527--6534 Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. [FBrf0213587] Morante et al., 2011, Development 138(4): 687--693 Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874] Popova et al., 2011, J. Cell Sci. 124(24): 4203--4212 Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. [FBrf0217175] Rosenbaum et al., 2011, Neuron 72(4): 602--615 XPORT-Dependent Transport of TRP and Rhodopsin. [FBrf0216705] Sprecher et al., 2011, Dev. Biol. 358(1): 33--43 The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil. [FBrf0215208] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Takemura et al., 2011, Curr. Biol. 21(24): 2077--2084 Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. [FBrf0217052] Ting et al., 2011, Genetics 188(1): 229--233 Focusing Transgene Expression in Drosophila by Coupling Gal4 With a Novel Split-LexA Expression System. [FBrf0213643] Tong et al., 2011, Neuron 71(3): 447--459 Rich Regulates Target Specificity of Photoreceptor Cells and N-Cadherin Trafficking in the Drosophila Visual System via Rab6. [FBrf0214681] Xiong and Rebay, 2011, Dev. Dyn. 240(7): 1745--1755 Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. [FBrf0213959] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...