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Gene Dmel\cl

General Information
Symbol	Dmel\cl	Species	D. melanogaster
Name	clot	Annotation symbol	CG11024
Feature type	protein_coding_gene	FlyBase ID	FBgn0000318
Gene Model Status	Current	Stock availability	53 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25E5-25E5	Sequence location	2L:5,520,135..5,521,382 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene clot is referred to in FlyBase by the symbol Dmel\cl (CG11024, FBgn0000318). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: disulfide oxidoreductase activity. There is experimental evidence that it is involved in the biological process: eye pigment biosynthetic process. 18 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; pigment cell. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Protein of unknown function DUF953, thioredoxin-like; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult spermathecae, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1623936_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cl. Gene sequence location is 2L:5520135..5521382.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cl: clot Eye color dark maroon to sepialike with age, is less extreme than sepia. Severely deficient in one of three enzyme activities required for the conversion of dihydroneopterin triphosphate to pyrimidodiazepine, a precursor of the drosopterins (Wiederrecht, Paton, and Brown, 1984, J. Biol. Chem. 259: 2195-2200). Claimed to accumulate 2-amino-4-hydroxypteridine, biopterin, sepiapterin, and xanthopterin (Nikla, 1972, Can. J. Genet. Cytol. 14: 105-11). Eye color autonomous when larval optic disk is transplanted into wildtype host (Beadle and Ephrussi, 1936, Genetics 21: 230). Larval Malpighian tubes pale yellow, distinguishable from wild type (Brehme and Demerec, 1942, Growth 6: 351-56). RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25E5-25E5   Limits computationally determined from genome sequence between P{lacW}vrik05901&P{PZ}cype03771 and P{lacW}Hel25Ek11511
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25E1-25E3   (determined by in situ hybridisation)   (Giordano et al., 2003)
Experimentally Determined Recombination Data
Location	2-16.5 (Reuter and Szidonya, 1983, Meyer, 1963) 2-18.83 (Kotarski et al., 1983)
Left of (cM)	Gpdh (Grell, 1967, Kotarski et al., 1983) l(2)26Ae (Kotarski et al., 1983)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cl-RA FBtr0079095  NM_135086   640   126 cl-RB FBtr0329967  NM_001273169   689   126 cl-RC FBtr0329968  NM_001273170   674   126
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cl-PA   FBpp0078728   14.7   126   5.26     NP_608930   AAF52253 cl-PB   FBpp0303002   14.7   126   5.26     NP_001260098   AGB92634 cl-PC   FBpp0303003   14.7   126   5.26     NP_001260099   AGB92635
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF953, thioredoxin-like (IPR010357) Thioredoxin-like fold (IPR012336)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695526   AE014134 AAF52253   AF503572 AAN03825   AE014134 AGB92634   AE014134 AGB92635   AI110151   AI297337   AI388826   AI404672   AW941183   AY060849 AAL28397   AY113391 AAM29396   AY232193   BE975025   BE977470   BI163608   BI166593   BI355323   BI486084   BI582155   CK657242   CK662099   CO154864   CO155013   CO190361   CO273668   CO276190   CO287649   CO333142   CZ466588   EC071512   EC086006   EC195254   EC217322   EC218292   EC224485   EC230532   EC236781   EC237154   EC261954   EC263159   EC267446   EV584791   EV593054   EV593465   EV598301   GH738793   GH738995   GH739571   GH739632   GH740568   GH741365   GH742161   GH742557   GH744872   GH745323   GH746084   GH746179   GH746691   GH761918   GH762566   GH765043   GH765068   GH765424   GH768072   GH769047
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMQ9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic hindgut   (Fisher et al., 2012) embryonic midgut chamber   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic proventriculus inner layer   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult spermathecae, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules    2247.4 Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea    1713.975 Larval Carcass    760.725 Adult Head    651 Adult Eye    1544.9 Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop    1765.2 Adult Midgut    1255.1 Adult Hindgut    767.1 Adult Malpighian Tubules    1769.4 Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart    1191.025 Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (625.85) Larval Midgut  (647.8) Larval Hindgut  (947.8) Larval Malpighian Tubules  (2247.4) Larval Fat Body  (707.5) Larval Salivary Gland  (743.7) Larval Trachea  (1713.975) Larval Carcass  (760.725) Adult Head  (651) Adult Eye  (1544.9) Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop  (1765.2) Adult Midgut  (1255.1) Adult Hindgut  (767.1) Adult Malpighian Tubules  (1769.4) Adult Fat Body  518 Adult Salivary Gland  (841.8) Adult Heart  (1191.025) Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary  (589.9) Adult Testis  (785.6) Adult Male Accessory Gland    343.7 Adult Carcass  508.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules  (2247.4) Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea  (1713.975) Larval Carcass    760.725 Adult Head    651 Adult Eye  (1544.9) Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop  (1765.2) Adult Midgut  (1255.1) Adult Hindgut    767.1 Adult Malpighian Tubules  (1769.4) Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart  (1191.025) Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules    2247.4 Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea    1713.975 Larval Carcass    760.725 Adult Head    651 Adult Eye    1544.9 Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop    1765.2 Adult Midgut    1255.1 Adult Hindgut    767.1 Adult Malpighian Tubules    1769.4 Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart    1191.025 Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules    2247.4 Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea    1713.975 Larval Carcass    760.725 Adult Head    651 Adult Eye    1544.9 Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop    1765.2 Adult Midgut    1255.1 Adult Hindgut    767.1 Adult Malpighian Tubules    1769.4 Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart    1191.025 Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  625.85 Larval Midgut  647.8 Larval Hindgut  (947.8) Larval Malpighian Tubules  (2247.4) Larval Fat Body  707.5 Larval Salivary Gland  743.7 Larval Trachea  (1713.975) Larval Carcass  760.725 Adult Head  651 Adult Eye  (1544.9) Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop  (1765.2) Adult Midgut  (1255.1) Adult Hindgut  767.1 Adult Malpighian Tubules  (1769.4) Adult Fat Body  518 Adult Salivary Gland  (841.8) Adult Heart  (1191.025) Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary  589.9 Adult Testis  785.6 Adult Male Accessory Gland    343.7 Adult Carcass  508.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules  (2247.4) Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea  1713.975 Larval Carcass    760.725 Adult Head    651 Adult Eye  1544.9 Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop  (1765.2) Adult Midgut  1255.1 Adult Hindgut    767.1 Adult Malpighian Tubules  (1769.4) Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart  1191.025 Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    625.85 Larval Midgut    647.8 Larval Hindgut    947.8 Larval Malpighian Tubules    2247.4 Larval Fat Body    707.5 Larval Salivary Gland    743.7 Larval Trachea    1713.975 Larval Carcass    760.725 Adult Head    651 Adult Eye    1544.9 Adult Brain    455.7 Adult Thoracic-Abdominal Ganglion    418.2 Adult Crop    1765.2 Adult Midgut    1255.1 Adult Hindgut    767.1 Adult Malpighian Tubules    1769.4 Adult Fat Body    518 Adult Salivary Gland    841.8 Adult Heart    1191.025 Adult VirginFemale Spermatheca    229.1 Adult InseminatedFemale Spermatheca    217.2 Adult Ovary    589.9 Adult Testis    785.6 Adult Male Accessory Gland    343.7 Adult Carcass    508.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    651   NA  Eye    1544.9   NA  Brain    455.7   625.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    418.2   NA  Crop    1765.2   647.8  Midgut    1255.1   947.8  Hindgut    767.1   2247.4  Malpighian Tubules    1769.4   707.5  Fat Body    518   743.7  Salivary Gland    841.8   NA  Heart    1191.025   1713.975  Trachea    NA   NA  VirginFemale Spermatheca    229.1   NA  InseminatedFemale Spermatheca    217.2   NA  Ovary    589.9   NA  Testis    785.6   NA  Male Accessory Gland    343.7   760.725  Carcass    508.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    200 digestive system, 4-day adult    146 digestive system, 20-day adult    124 fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering    111 carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male    248 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3  (71) central nervous system, pupae P8  (37) head, virgin 1-day female  (38) head, virgin 4-day female  (38) head, virgin 20-day female  (33) head, mated 1-day female  (40) head, mated 4-day female  (37) head, mated 20-day female  (33) head, mated 1-day male  (46) head, mated 4-day male  (52) head, mated 20-day male  (73) salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae  (33) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (200) digestive system, 4-day adult  (146) digestive system, 20-day adult  (124) fat body, larvae L3 wandering  (38) fat body, white prepupae  (60) fat body, pupae P8  (71) carcass, larvae L3 wandering  (111) carcass, 1-day adult  (42) carcass, 4-day adult  (41) carcass, 20-day adult  (47) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (94) testis, mated 4-day male  (248) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (200) digestive system, 4-day adult  (146) digestive system, 20-day adult  (124) fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering  (111) carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male  (248) accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    200 digestive system, 4-day adult    146 digestive system, 20-day adult    124 fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering    111 carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male    248 accessory gland, mated 4-day male    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    200 digestive system, 4-day adult    146 digestive system, 20-day adult    124 fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering    111 carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male    248 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (121) central nervous system, larvae L3  (71) central nervous system, pupae P8  (37) head, virgin 1-day female  (38) head, virgin 4-day female  (38) head, virgin 20-day female  (33) head, mated 1-day female  (40) head, mated 4-day female  (37) head, mated 20-day female  (33) head, mated 1-day male  (46) head, mated 4-day male  (52) head, mated 20-day male  (73) salivary gland, larvae L3 wandering  (38) salivary gland, white prepupae  (33) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (200) digestive system, 4-day adult  (146) digestive system, 20-day adult  (124) fat body, larvae L3 wandering  (38) fat body, white prepupae  (60) fat body, pupae P8  (71) carcass, larvae L3 wandering  (111) carcass, 1-day adult  (42) carcass, 4-day adult  (41) carcass, 20-day adult  (47) ovary, virgin 4-day female  (79) ovary, mated 4-day female  (94) testis, mated 4-day male  (248) accessory gland, mated 4-day male  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  121 central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering  111 digestive system, 1-day adult  (200) digestive system, 4-day adult  (146) digestive system, 20-day adult  124 fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering  111 carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male  (248) accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    121 central nervous system, larvae L3    71 central nervous system, pupae P8    37 head, virgin 1-day female    38 head, virgin 4-day female    38 head, virgin 20-day female    33 head, mated 1-day female    40 head, mated 4-day female    37 head, mated 20-day female    33 head, mated 1-day male    46 head, mated 4-day male    52 head, mated 20-day male    73 salivary gland, larvae L3 wandering    38 salivary gland, white prepupae    33 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    200 digestive system, 4-day adult    146 digestive system, 20-day adult    124 fat body, larvae L3 wandering    38 fat body, white prepupae    60 fat body, pupae P8    71 carcass, larvae L3 wandering    111 carcass, 1-day adult    42 carcass, 4-day adult    41 carcass, 20-day adult    47 ovary, virgin 4-day female    79 ovary, mated 4-day female    94 testis, mated 4-day male    248 accessory gland, mated 4-day male    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    145 embryo 02-04hr    158 embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1    116 larva L2    118 larva L3 12hr old    136 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    137 white prepupae new    115 white prepupae 12hr    104 white prepupae 24hr    106 pupae 2d postWPP    106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day    113 adult male 05day    133 adult male 30day    133 adult female 01day    106 adult female 05day    113 adult female 30day    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (145) embryo 02-04hr  (158) embryo 04-06hr  (84) embryo 06-08hr  (34) embryo 08-10hr  (43) embryo 10-12hr  (84) embryo 12-14hr  (51) embryo 14-16hr  (61) embryo 16-18hr  (60) embryo 18-20hr  (61) embryo 20-22hr  (78) embryo 22-24hr  (66) larva L1  (116) larva L2  (118) larva L3 12hr old  (136) larva L3 puffstage 1-2  (104) larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (137) white prepupae new  (115) white prepupae 12hr  (104) white prepupae 24hr  (106) pupae 2d postWPP  (106) pupae 3d postWPP  (95) pupae 4d postWPP  (85) adult male 01day  (113) adult male 05day  (133) adult male 30day  (133) adult female 01day  (106) adult female 05day  (113) adult female 30day  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (145) embryo 02-04hr  (158) embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1  (116) larva L2  (118) larva L3 12hr old  (136) larva L3 puffstage 1-2  104 larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (137) white prepupae new  (115) white prepupae 12hr  104 white prepupae 24hr  106 pupae 2d postWPP  106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day  (113) adult male 05day  (133) adult male 30day  (133) adult female 01day  106 adult female 05day  (113) adult female 30day  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    145 embryo 02-04hr    158 embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1    116 larva L2    118 larva L3 12hr old    136 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    137 white prepupae new    115 white prepupae 12hr    104 white prepupae 24hr    106 pupae 2d postWPP    106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day    113 adult male 05day    133 adult male 30day    133 adult female 01day    106 adult female 05day    113 adult female 30day    124 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    145 embryo 02-04hr    158 embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1    116 larva L2    118 larva L3 12hr old    136 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    137 white prepupae new    115 white prepupae 12hr    104 white prepupae 24hr    106 pupae 2d postWPP    106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day    113 adult male 05day    133 adult male 30day    133 adult female 01day    106 adult female 05day    113 adult female 30day    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (145) embryo 02-04hr  (158) embryo 04-06hr  (84) embryo 06-08hr  (34) embryo 08-10hr  (43) embryo 10-12hr  (84) embryo 12-14hr  (51) embryo 14-16hr  (61) embryo 16-18hr  (60) embryo 18-20hr  (61) embryo 20-22hr  (78) embryo 22-24hr  (66) larva L1  (116) larva L2  (118) larva L3 12hr old  (136) larva L3 puffstage 1-2  (104) larva L3 puffstage 3-6  (135) larva L3 puffstage 7-9  (137) white prepupae new  (115) white prepupae 12hr  (104) white prepupae 24hr  (106) pupae 2d postWPP  (106) pupae 3d postWPP  (95) pupae 4d postWPP  (85) adult male 01day  (113) adult male 05day  (133) adult male 30day  (133) adult female 01day  (106) adult female 05day  (113) adult female 30day  (124) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (145) embryo 02-04hr  (158) embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1  116 larva L2  118 larva L3 12hr old  136 larva L3 puffstage 1-2  104 larva L3 puffstage 3-6  135 larva L3 puffstage 7-9  137 white prepupae new  115 white prepupae 12hr  104 white prepupae 24hr  106 pupae 2d postWPP  106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day  113 adult male 05day  133 adult male 30day  133 adult female 01day  106 adult female 05day  113 adult female 30day  124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    145 embryo 02-04hr    158 embryo 04-06hr    84 embryo 06-08hr    34 embryo 08-10hr    43 embryo 10-12hr    84 embryo 12-14hr    51 embryo 14-16hr    61 embryo 16-18hr    60 embryo 18-20hr    61 embryo 20-22hr    78 embryo 22-24hr    66 larva L1    116 larva L2    118 larva L3 12hr old    136 larva L3 puffstage 1-2    104 larva L3 puffstage 3-6    135 larva L3 puffstage 7-9    137 white prepupae new    115 white prepupae 12hr    104 white prepupae 24hr    106 pupae 2d postWPP    106 pupae 3d postWPP    95 pupae 4d postWPP    85 adult male 01day    113 adult male 05day    133 adult male 30day    133 adult female 01day    106 adult female 05day    113 adult female 30day    124 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    191 embryonic 1182-4H    118 embryonic GM2    200 embryonic Kc167    57 embryonic S1    306 embryonic S3    81 leg disc CME L1    246 wing disc CME-W2    204 wing disc ML-DmD8    101 wing disc ML-DmD9    142 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    247 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    222 antennal disc ML-DmD20-c5    204 mixed discs ML-DmD4-c1    120 CNS ML-DmBG1-c1    157 CNS ML-DmBG2-c2    79 tumorous blood cells mbn2    142 ovary fGS/OSS    110 ovary OSC    98 ovary OSS    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (96) Schneider line 2 Sg4  (191) embryonic 1182-4H  (118) embryonic GM2  (200) embryonic Kc167  (57) embryonic S1  (306) embryonic S3  (81) leg disc CME L1  (246) wing disc CME-W2  (204) wing disc ML-DmD8  (101) wing disc ML-DmD9  (142) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (247) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (222) antennal disc ML-DmD20-c5  (204) mixed discs ML-DmD4-c1  (120) CNS ML-DmBG1-c1  (157) CNS ML-DmBG2-c2  (79) tumorous blood cells mbn2  (142) ovary fGS/OSS  (110) ovary OSC  (98) ovary OSS  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4  (191) embryonic 1182-4H  (118) embryonic GM2  (200) embryonic Kc167    57 embryonic S1  (306) embryonic S3    81 leg disc CME L1  (246) wing disc CME-W2  (204) wing disc ML-DmD8  101 wing disc ML-DmD9  (142) wing disc ML-DmD16-c3    74 wing disc ML-DmD21  (247) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11  (222) antennal disc ML-DmD20-c5  (204) mixed discs ML-DmD4-c1  (120) CNS ML-DmBG1-c1  (157) CNS ML-DmBG2-c2    79 tumorous blood cells mbn2  (142) ovary fGS/OSS  (110) ovary OSC    98 ovary OSS    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    191 embryonic 1182-4H    118 embryonic GM2    200 embryonic Kc167    57 embryonic S1    306 embryonic S3    81 leg disc CME L1    246 wing disc CME-W2    204 wing disc ML-DmD8    101 wing disc ML-DmD9    142 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    247 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    222 antennal disc ML-DmD20-c5    204 mixed discs ML-DmD4-c1    120 CNS ML-DmBG1-c1    157 CNS ML-DmBG2-c2    79 tumorous blood cells mbn2    142 ovary fGS/OSS    110 ovary OSC    98 ovary OSS    67 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    191 embryonic 1182-4H    118 embryonic GM2    200 embryonic Kc167    57 embryonic S1    306 embryonic S3    81 leg disc CME L1    246 wing disc CME-W2    204 wing disc ML-DmD8    101 wing disc ML-DmD9    142 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    247 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    222 antennal disc ML-DmD20-c5    204 mixed discs ML-DmD4-c1    120 CNS ML-DmBG1-c1    157 CNS ML-DmBG2-c2    79 tumorous blood cells mbn2    142 ovary fGS/OSS    110 ovary OSC    98 ovary OSS    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (96) Schneider line 2 Sg4  (191) embryonic 1182-4H  (118) embryonic GM2  (200) embryonic Kc167  (57) embryonic S1  (306) embryonic S3  (81) leg disc CME L1  (246) wing disc CME-W2  (204) wing disc ML-DmD8  (101) wing disc ML-DmD9  (142) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (247) wing disc ML-DmD32  (129) haltere disc ML-DmD17-c3  (70) eye-antennal disc ML-DmD11  (222) antennal disc ML-DmD20-c5  (204) mixed discs ML-DmD4-c1  (120) CNS ML-DmBG1-c1  (157) CNS ML-DmBG2-c2  (79) tumorous blood cells mbn2  (142) ovary fGS/OSS  (110) ovary OSC  (98) ovary OSS  (67) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4  (191) embryonic 1182-4H  118 embryonic GM2  (200) embryonic Kc167    57 embryonic S1  (306) embryonic S3    81 leg disc CME L1  (246) wing disc CME-W2  (204) wing disc ML-DmD8  101 wing disc ML-DmD9  142 wing disc ML-DmD16-c3    74 wing disc ML-DmD21  (247) wing disc ML-DmD32  129 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11  (222) antennal disc ML-DmD20-c5  (204) mixed discs ML-DmD4-c1  120 CNS ML-DmBG1-c1  (157) CNS ML-DmBG2-c2    79 tumorous blood cells mbn2  142 ovary fGS/OSS  110 ovary OSC    98 ovary OSS    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    96 Schneider line 2 Sg4    191 embryonic 1182-4H    118 embryonic GM2    200 embryonic Kc167    57 embryonic S1    306 embryonic S3    81 leg disc CME L1    246 wing disc CME-W2    204 wing disc ML-DmD8    101 wing disc ML-DmD9    142 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    247 wing disc ML-DmD32    129 haltere disc ML-DmD17-c3    70 eye-antennal disc ML-DmD11    222 antennal disc ML-DmD20-c5    204 mixed discs ML-DmD4-c1    120 CNS ML-DmBG1-c1    157 CNS ML-DmBG2-c2    79 tumorous blood cells mbn2    142 ovary fGS/OSS    110 ovary OSC    98 ovary OSS    67 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    161 Cadmium 50 mM 12 hrs, larvae L3    126 Cadmium 50 mM 48 hrs, 4-day adult    106 Cadmium 100 mM 48 hrs, 4-day adult    103 Copper 0.5 mM 12 hrs, larvae L3    157 Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    133 Ethanol 10% 3 hrs, larvae L3    115 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult    108 Rotenone 2 μg 12 hrs, larvae L3    123 Rotenone 8 μg 12 hrs, larvae L3    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (77) cold shock, 4-day adult  (63) heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3  (161) Cadmium 50 mM 12 hrs, larvae L3  (126) Cadmium 50 mM 48 hrs, 4-day adult  (106) Cadmium 100 mM 48 hrs, 4-day adult  (103) Copper 0.5 mM 12 hrs, larvae L3  (157) Copper 15 mM 48 hrs, 4-day adult  (93) Zinc 5 mM 12 hrs, larvae L3  (92) Zinc 4.5 mM 48 hrs, 4-day adult  (72) Ethanol 2.5% 3 hrs, larvae L3  (98) Ethanol 5% 3 hrs, larvae L3  (133) Ethanol 10% 3 hrs, larvae L3  (115) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (102) Caffeine 25 mg/ml 48 hrs, 4-day adult  (74) Paraquat 5 mM 48 hrs, 4-day adult  (91) Paraquat 10 mM 48 hrs, 4-day adult  (108) Rotenone 2 μg 12 hrs, larvae L3  (123) Rotenone 8 μg 12 hrs, larvae L3  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3  (161) Cadmium 50 mM 12 hrs, larvae L3  (126) Cadmium 50 mM 48 hrs, 4-day adult  106 Cadmium 100 mM 48 hrs, 4-day adult  103 Copper 0.5 mM 12 hrs, larvae L3  (157) Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3  (133) Ethanol 10% 3 hrs, larvae L3  (115) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult  (108) Rotenone 2 μg 12 hrs, larvae L3  (123) Rotenone 8 μg 12 hrs, larvae L3  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    161 Cadmium 50 mM 12 hrs, larvae L3    126 Cadmium 50 mM 48 hrs, 4-day adult    106 Cadmium 100 mM 48 hrs, 4-day adult    103 Copper 0.5 mM 12 hrs, larvae L3    157 Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    133 Ethanol 10% 3 hrs, larvae L3    115 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult    108 Rotenone 2 μg 12 hrs, larvae L3    123 Rotenone 8 μg 12 hrs, larvae L3    164 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    161 Cadmium 50 mM 12 hrs, larvae L3    126 Cadmium 50 mM 48 hrs, 4-day adult    106 Cadmium 100 mM 48 hrs, 4-day adult    103 Copper 0.5 mM 12 hrs, larvae L3    157 Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    133 Ethanol 10% 3 hrs, larvae L3    115 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult    108 Rotenone 2 μg 12 hrs, larvae L3    123 Rotenone 8 μg 12 hrs, larvae L3    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (77) cold shock, 4-day adult  (63) heat shock, 4-day adult  (108) Cadmium 50 mM 6 hrs, larvae L3  (161) Cadmium 50 mM 12 hrs, larvae L3  (126) Cadmium 50 mM 48 hrs, 4-day adult  (106) Cadmium 100 mM 48 hrs, 4-day adult  (103) Copper 0.5 mM 12 hrs, larvae L3  (157) Copper 15 mM 48 hrs, 4-day adult  (93) Zinc 5 mM 12 hrs, larvae L3  (92) Zinc 4.5 mM 48 hrs, 4-day adult  (72) Ethanol 2.5% 3 hrs, larvae L3  (98) Ethanol 5% 3 hrs, larvae L3  (133) Ethanol 10% 3 hrs, larvae L3  (115) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (102) Caffeine 25 mg/ml 48 hrs, 4-day adult  (74) Paraquat 5 mM 48 hrs, 4-day adult  (91) Paraquat 10 mM 48 hrs, 4-day adult  (108) Rotenone 2 μg 12 hrs, larvae L3  (123) Rotenone 8 μg 12 hrs, larvae L3  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult  108 Cadmium 50 mM 6 hrs, larvae L3  (161) Cadmium 50 mM 12 hrs, larvae L3  126 Cadmium 50 mM 48 hrs, 4-day adult  106 Cadmium 100 mM 48 hrs, 4-day adult  103 Copper 0.5 mM 12 hrs, larvae L3  (157) Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3  133 Ethanol 10% 3 hrs, larvae L3  115 Caffeine 1.5 mg/ml 4 hrs, larvae L3  109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult  108 Rotenone 2 μg 12 hrs, larvae L3  123 Rotenone 8 μg 12 hrs, larvae L3  (164) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    77 cold shock, 4-day adult    63 heat shock, 4-day adult    108 Cadmium 50 mM 6 hrs, larvae L3    161 Cadmium 50 mM 12 hrs, larvae L3    126 Cadmium 50 mM 48 hrs, 4-day adult    106 Cadmium 100 mM 48 hrs, 4-day adult    103 Copper 0.5 mM 12 hrs, larvae L3    157 Copper 15 mM 48 hrs, 4-day adult    93 Zinc 5 mM 12 hrs, larvae L3    92 Zinc 4.5 mM 48 hrs, 4-day adult    72 Ethanol 2.5% 3 hrs, larvae L3    98 Ethanol 5% 3 hrs, larvae L3    133 Ethanol 10% 3 hrs, larvae L3    115 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    102 Caffeine 25 mg/ml 48 hrs, 4-day adult    74 Paraquat 5 mM 48 hrs, 4-day adult    91 Paraquat 10 mM 48 hrs, 4-day adult    108 Rotenone 2 μg 12 hrs, larvae L3    123 Rotenone 8 μg 12 hrs, larvae L3    164 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GM02967 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000318 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11024-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cl Stages(s) 4-6 Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable clc00597 viable, with Scer\GAL4pnr-MD237 clGD17048 viable (with cl1) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 cl9d1 viable (with cl2) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 cl9d1 viable (with cl9d1.Δ6) cl1 cl2 viable (with cl9d1.Δ22) cl1 cl2 viable (with cl9d1.Δ76) cl1 cl2 viable (with cl9d1) cl1 cl2 viable (with Df(2L)cl7) cl9d1.Δ22 cl9d1 viable (with Df(2L)cl-h1) cl9d1.Δ22 cl9d1 Sterility Allele fertile clc00597 Other Phenotypes Allele eye color defective cl1 cl2 clH60 clT60 eye color defective (with cl1) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 eye color defective (with cl2) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 eye color defective (with cl9d1.Δ6) cl1 cl2 eye color defective (with cl9d1.Δ22) cl1 cl2 eye color defective (with cl9d1.Δ76) cl1 cl2 eye color defective (with Df(2L)cl7) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 eye color defective (with Df(2L)cl-h1) cl9d1.Δ6 cl9d1.Δ22 cl9d1.Δ76 Phenotype manifest in Allele Malpighian tubule cl1 cl2 pigment cell cl1 cl2 clH60 clT60 pigment cell (with cl1) cl9d1.Δ22 cl9d1.Δ6 cl9d1.Δ76 pigment cell (with cl2) cl9d1.Δ22 cl9d1.Δ6 cl9d1.Δ76 pigment cell (with cl9d1.Δ6) cl1 cl2 pigment cell (with cl9d1.Δ22) cl1 cl2 pigment cell (with cl9d1.Δ76) cl1 cl2 pigment cell (with Df(2L)cl7) cl9d1.Δ22 cl9d1.Δ6 cl9d1.Δ76 pigment cell (with Df(2L)cl-h1) cl9d1.Δ22 cl9d1.Δ6 cl9d1.Δ76
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of cl Class Mutagen Stocks Known lesion cl1 spontaneous 42 Yes cl4 ethyl methanesulfonate 5 -- cl2 3 Yes clc00597 piggyBac transposase 2 -- clCA1 X ray 1 -- cl3 ethyl methanesulfonate 0 -- cl9d1.Δ22 Delta2-3 0 Yes cl9d1.Δ6 Delta2-3 0 Yes cl9d1.Δ76 Delta2-3 0 Yes cl9d1 P-element activity 0 Yes clH60 X ray 0 -- clT60 X ray 0 -- clunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cl Class Mutagen Stocks Known lesion clGD17048 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes clKK109215 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes clGD6660 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes clNIG.11024R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes clScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)cl1 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)cl2 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)cl7 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Davis and MacIntyre, 1988, Knipple et al., 1991) Df(2L)cl9d1.Δ6 (Giordano et al., 2003) Df(2L)cl9d1.Δ76 (Giordano et al., 2003) Df(2L)cl-h1 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)cl-h2 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)cl-h3 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)cl-h4 (Kotarski et al., 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Eberl et al., 1997) Df(2L)dp-cl-h1 (Szidonya and Reuter, 1988) Df(2L)dp-cl-h2 (Szidonya and Reuter, 1988) Df(2L)dp-cl-h3 (Szidonya and Reuter, 1988) Df(2L)Exel6012 (Ryder, 2004.4.26) Df(2L)GpdhA (Kotarski et al., 1983) Df(2L)sc19-4 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-12 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) In(2L)Scorv17LC158R   Ts(YSt;2Lt)B236+Ts(YSt;2Rt)D222 (Kotarski et al., 1983)
Not disrupted in	Df(2L)dp-h25 (Bryant et al., 1988) Df(2L)dp-h28 (Bryant et al., 1988) Df(2L)ed1 (Reuter and Szidonya, 1983, Bryant et al., 1988) Df(2L)ed2 (Reuter and Szidonya, 1983) Df(2L)M24F11 (Reuter and Szidonya, 1983, Bryant et al., 1988) Df(2L)M24F-B (Reuter and Szidonya, 1983, Bryant et al., 1988) Df(2L)sc19-1 (Szidonya and Reuter, 1988, Bryant et al., 1988, Szidonya and Reuter, 1988) Df(2L)sc19-3 (Bryant et al., 1988) Df(2L)sc19-5 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-6 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-7 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)sc19-8 (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkv2 (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Df(2L)tkv3 (Reuter and Szidonya, 1983, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988) Ts(YLt;2Lt)H151+Ts(YSt;2Rt)D222 (Kotarski et al., 1983) Ts(YLt;2Lt)H164+Ts(YSt;2Rt)H151 (Kotarski et al., 1983)
Duplicated in	Dp(2;1)B19 (Bryant et al., 1988)
Not duplicated in	Ts(2Lt;4Lt)b (Morgan, 1947)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6660} NA P{GD17048} NA P{KK109215} NA P{NIG.11024R} NA P{UAS-cl.G} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions blood{}cl1 NA PBac{PB}clc00597 NA insertion of enhancer trap P{PZ}cl9d1 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
eye pigment biosynthetic process inferred from mutant phenotype (Giordano et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
disulfide oxidoreductase activity non-traceable author statement (Peluso, 2002.4.17)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cl - fs(1)h anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cl allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68728 DroID - A comprehensive database of gene and protein interactions. • FBgn0000318 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43938
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG60CJ3K Dipteran inclusive ortholog search EOG6ZKJWQ Insect inclusive ortholog search EOG6V15XK Arthropod inclusive ortholog search EOG6K3JD0 Metazoa inclusive ortholog search EOG6DG2J0
Orthologs in Drosophila Species (EOG60CJ3K)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cl     Drosophila simulans   Dsim\GD23345 Y   Drosophila sechellia   Dsec\GM18551 Y   Drosophila erecta   Dere\GG25076 Y   Drosophila yakuba   Dyak\cl Y   Drosophila ananassae   Dana\GF15144 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10712 Y   Drosophila persimilis   Dper\GL25848 Y   Drosophila willistoni   Dwil\GK15089 Y   Drosophila virilis   Dvir\GJ19575 Y   Drosophila mojavensis   Dmoj\GI17989 Y   Drosophila grimshawi   Dgri\GH10293 Y
Orthologs in non-Drosophila Dipterans (EOG6ZKJWQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014064   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012116   Anopheles gambiae Malaria mosquito  Agam\GRX3   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801425
Orthologs in non-Dipteran Insects (EOG6V15XK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\cl Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003859 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14853 Y Atta cephalotes Leafcutter ant  Acep\ACEP18435 Y Atta cephalotes Leafcutter ant  Acep\ACEP18436 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20508 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27440 Y Linepithema humile Argentine ant  Lhum\LH23374 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17100 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000630 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI36980 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006709 Y Pediculus humanus Human body louse  Phum\PHUM012680 Y Pediculus humanus Human body louse  Phum\PHUM098430 Y
Orthologs in non-Insect Arthropods (EOG6K3JD0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_302246 Y
Orthologs in non-Arthropod Metazoa (EOG6DG2J0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y71H2AR.1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003766gn Y Danio rerio Zebrafish  Drer\txndc17 Y Gallus gallus Domestic chicken  Ggal\TXNDC17 Y Mus musculus House mouse  Mmus\Txndc17 Y Rattus norvegicus Norway rat  Rnor\Txndc17 Y Homo sapiens Human  Hsap\TXNDC17 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\TXNDC17
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23345 Drosophila sechellia Dsec\GM18551 Drosophila erecta Dere\GG25076 Drosophila yakuba Dyak\cl Drosophila ananassae Dana\GF15144 Drosophila pseudoobscura pseudoobscura Dpse\GA10712 Drosophila persimilis Dper\GL25848 Drosophila willistoni Dwil\GK15089 Drosophila virilis Dvir\GJ19575 Drosophila mojavensis Dmoj\GI17989 Drosophila grimshawi Dgri\GH10293
Stocks & Reagents
Stocks Listed in FlyBase ( 53 )
Bloomington	261 cl1 4902 Gpo-1n322/CyO, cl4 1298 cl1 fy2 nub2 10188 w1118; PBac{PB}clc00597
Harvard	- PBac{PB}clc00597
Kyoto	105818 cl1 101800 cl2 ; T(Y;2)E 107942 Gpo-1n322/CyO, cl4 106270 cl1 fy2 nub2 105796 ast4 dpov1 cl1
VDRC	v101458 P{KK109215}VIE-260B v46489 w1118; P{GD17048}v46489/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR35L07 BACR44J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02967 RE06767
Other clones	yak-ad_CG11024
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH09637 GH19853 GH24466 GM30378 LP11617 LP22067 LP23378 RE03044 RE69457 RH20106
Other clones	bs37g08 bs64d08 Dmel_dig_014429_0704_0983 Dmel_neb_010589_0672_3187 Dmel_neb_013217_0848_2092 Dmel_neb_014059_0674_2571 EK047914 EK066363 EK111808 EK119920 EK305902 EN04937 EN05210 RP01193 RP001004839 RP001006586 RP001006762 RP001010492 RP001015335 RP001018068 RP001019308 RP001019969 RP001020135 RP001021671 RP001027044 RP001034542 RP001035747 RP001036744 RP001038875 RP001040495 RP001045735 RP001050338 RP001054565
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000318 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43938
Antibody Information
Other Information
Discoverer
	Bridges, 3rd Jan. 1927.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cl BcDNA:RE06767 (FlyBase, 1996-) Source for merge of: cl CG11024 (FlyBase, 1996-)
Additional comments	Source for merge of cl BcDNA:RE06767 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of cl CG11024 was sequence comparison (date:021108). (FlyBase, 1996-)
Other Comments
	cl is not the structural gene for Sptr. (Ruiz-Vazquez et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135086 NM_001273169 NM_001273170 RefSeq (Proteins) • NP_608930 NP_001260098 NP_001260099 DDBJ / EMBL / GenBank • AA695526 AAF52253 AAL28397 AAM29396 AAN03825 AF503572 AGB92634 AGB92635 AW941183 AY060849 AY113391 BI166593 CZ466588 Entrez Gene - A searchable database of RefSeq genes. • 43938 UniProtKB/TrEMBL • Q9VMQ9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein of unknown function DUF953, thioredoxin-like (IPR010357) Thioredoxin-like fold (IPR012336) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM02967
Linkouts
	BioGRID - A database of protein and genetic interactions • 68728 DroID - A comprehensive database of gene and protein interactions. • FBgn0000318 DRSC - Results from RNAi screens. • FBgn0000318 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000318 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11024-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000318 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43938 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43938 modMine - Data generated by the modENCODE project. • FBgn0000318
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:RE06767   CG11024 (Keleman et al., 2009.8.5) cl (Svensson and Larsson, 2007, Japanese National Institute of Genetics, 2012.5.21, Malone et al., 2012)
Name Synonym	clot (Svensson and Larsson, 2007, Rendina et al., 2010)
Secondary FlyBase IDs
	FBgn0031709 FBgn0063070
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Book  ( 2 )
Recent research papers ( 1 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Show all research papers ...