cli, clift, ey-2
transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development - also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate -Retinal axon guidance requires integration of Eya and the JAK/STAT pathway into phosphotyrosine-based signaling circuitries
Please see the JBrowse view of Dmel\eya for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
3.5 (northern blot)
None of the polypeptides share 100% sequence identity.
766, 760 (aa); 80 (kD)
One of a couple of products generated by alternative splicing.
Interacts with Dac and So.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eya using the Feature Mapper tool.
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
In stage 12 embryos, eya is expressed in the posterior lobe but not in the anterior lobe of the optic primordium.
eya is expressed in a crescent-shaped domain that partially overlaps with the optic lobe (stage 10-12) and Bolwig's organ (stage 10-13).
eya protein is expressed in follicle stem cells, prefollicle cells, and oocyte associated (main body) follicle cells, but not in interfollicle (stalk) cells, and polar follicle cells.
eya protein is expressed during oogenesis in prefollicle cells.
At oogenesis stage S10A, eya is expressed in the nurse cell follicle cells and also marks the leading edge follicle cells.
Expressed in somatic gonadal precursors but not in ensheathing cells in stage 17 embryos.
eya protein can be detected in mid to late stage spermatogonial cysts.
eya protein expression is first detected in second instar larvae in the eye portion of the eye-antennal disc. It is observed as a gradient with the posterior and edge regions of the disc showing stronger expression than the central and anterior portions. As the morphogenetic furrow forms, the protein is found in a gradient anterior to it with the strongest expression close to the furrow. Protein expression persists in cells after the furrow passes. Posterior to the furrow, expression is patterned in clusters of developing neurons.
GBrowse - Visual display of RNA-Seq signals
View Dmel\eya in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: eya ey-2
Source for merge of: eya BcDNA:LD16029
Source for merge of eya BcDNA:LD16029 was a shared cDNA ( date:030728 ).
eya is required for normal cone cell and pigment cell development.
eya is a key repressor of polar follicle cell fate during oogenesis.
so and eya are two mediators of the eye inducing activity of ey. ey appears to induce the initial expression of so and eya in the eye disc. so and eya then participate in a positive feedback loop that regulates the expression of all three genes. In the embryonic head, however, so acts in parallel to ey and toy. The epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.
Mutations in one region of eya cause embryonic lethality, whereas mutations throughout the gene cause defects in eye development.
eya is required for both fat body and gonadal mesoderm development in the embryo.
In addition to a role in eye development, eya alleles can be embryonic lethal, female sterile or affect the development of the ocelli and regions of the adult brain. The eye-specific alleles undergo transvection and appear to define sequences required for eye-specific expression of the gene.
eya is required at an early stage of gonadogenesis, the specification of gonadal precursors.
Alleles of eya that disrupt coalescence of the embryonic gonad have been identified in a screen for mutations disrupting pole cell migration and gonad formation.
Complementation analysis with lethal alleles suggests 'clift' and 'eya' are allelic though the eye function, in part, is independently mutable.
'clift' activity is required for the survival of eye progenitor cells at a critical stage in morphogenesis. Molecular analysis identifies a nuclear protein expressed in progenitor cells prior to differentiation. Alleles with partial eye development have abnormally high cell death anterior to the furrow.
Adult phenotype is no or reduced eye, eye disc phenotype is a small disc with no or few clusters apparent due to precursor cell defects.