FB2021_02, released April 13, 2021

Gene: Dmel\eya

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General Information
Symbol
Dmel\eya
Species
D. melanogaster
Name
eyes absent
Annotation Symbol
CG9554
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000320
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Summary
eyes absent (eya) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by ey, dac, and so. The product of eya regulates eye, gonad, and brain development as well as axon pathfinding. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Also Known As

cli, clift, ey-2

Key Links
Genomic Location
Cytogenetic map
26E1-26E2
Sequence location
2L:6,527,447..6,546,976 [-]
Recombination map
2-21
RefSeq locus
NT_033779 REGION:6527447..6546976
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (36 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables phosphoprotein phosphatase activity
inferred from mutant phenotype
(Liu et al., 2012)
enables protein tyrosine phosphatase activity, metal-dependent
inferred from direct assay
(Rayapureddi et al., 2003)
enables protein tyrosine phosphatase activity
inferred from direct assay
(Tootle et al., 2003)
enables transcription coactivator activity
inferred from mutant phenotype
(Jin and Mardon, 2016)
enables transcription factor binding
inferred from physical interaction with FLYBASE:so; FB:FBgn0003460
(Kenyon et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein tyrosine phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (28 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
(Xiong et al., 2009)
involved_in Bolwig's organ morphogenesis
inferred from mutant phenotype
(Suzuki and Saigo, 2000)
involved_in compound eye cone cell differentiation
inferred from mutant phenotype
(Karandikar et al., 2014)
involved_in compound eye development
inferred from mutant phenotype
(Jin and Mardon, 2016, Xiong et al., 2009, Rayapureddi et al., 2003)
involved_in compound eye photoreceptor development
inferred from mutant phenotype
(Tavsanli et al., 2004)
involved_in eye-antennal disc morphogenesis
inferred from mutant phenotype
(assigned by UniProt )
(Bonini et al., 1993)
involved_in gonad development
inferred from mutant phenotype
(Weyers et al., 2011)
involved_in innate immune response
inferred from genetic interaction with FLYBASE:DNaseII; FB:FBgn0000477
(Liu et al., 2012)
involved_in larval somatic muscle development
inferred from mutant phenotype
(Liu et al., 2009)
involved_in male gonad development
inferred from mutant phenotype
(DeFalco et al., 2003)
involved_in mesoderm development
inferred from mutant phenotype
(Vining et al., 2005)
involved_in negative regulation of cell fate specification
inferred from mutant phenotype
(Bai and Montell, 2002)
involved_in optic lobe placode formation
inferred from mutant phenotype
(Daniel et al., 1999)
involved_in ovarian follicle cell development
inferred from mutant phenotype
(Dai et al., 2017, Medioni and Noselli, 2005)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Xiong et al., 2009)
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
(Xiong et al., 2009)
involved_in pigment cell development
inferred from mutant phenotype
(Karandikar et al., 2014)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Blanco et al., 2010)
involved_in positive regulation of transcription by RNA polymerase II
inferred from physical interaction with FLYBASE:so; FB:FBgn0003460
(Kenyon et al., 2005)
inferred from mutant phenotype
(Jin and Mardon, 2016)
involved_in protein dephosphorylation
inferred from direct assay
(Rayapureddi et al., 2003, Tootle et al., 2003)
involved_in response to light stimulus
inferred from mutant phenotype
(Bachleitner et al., 2007)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Vining et al., 2005)
involved_in spermatogenesis
inferred from mutant phenotype
(Fabrizio et al., 2003)
involved_in ventral cord development
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
(Xiong et al., 2009)
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in anatomical structure development
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in histone dephosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of DNA repair
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in cytosol
inferred from direct assay
(Xiong et al., 2009)
located_in nucleus
inferred from direct assay
(assigned by UniProt )
(Bonini et al., 1993)
inferred from direct assay
(Dai et al., 2017, Xiong et al., 2009, Fabrizio et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the HAD-like hydrolase superfamily. EYA family. (Q05201)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
eyes absent (eya) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by ey, dac, and so. The product of eya regulates eye, gonad, and brain development as well as axon pathfinding. [Date last reviewed: 2018-09-06]
Gene Group (FlyBase)
EYA FAMILY PROTEIN TYROSINE PHOSPHATASES -
Eyes-Absent (EYA) family phosphatases function as a protein tyrosine phosphatase and as a transcription factor, with EYA itself and RNA polymerase II CTD repeats as targets. They are members of the Haloacid Dehalogenase (HAD) superfamily that require a metal for catalytic activity and use aspartic acid as a nucleophile instead of the classic cysteine residue. Only one member is found in Drosophila - eya is involved in numerous processes including the regulation of the anti-DNA immune response, retinal determination, spermatocyte development and oogenesis. (Adapted from FBrf0228712 and FBrf0227974.)
Protein Function (UniProtKB)
Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity (PubMed:14628052, PubMed:14628053). The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development (PubMed:9428512, PubMed:9428513). Required for the survival of eye progenitor cells at a critical stage in morphogenesis (PubMed:8431945).
(UniProt, Q05201)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
cli: clift (C. Nusslein-Volhard)
Embryonic lethal. Defect in head involution. No segmental movements. Shows abdominal transformations in combination with Pc-like mutants.
eya: eyes absent
Eye facets completely absent in strong alleles; other aspects of head development appear normal; antennae and ocelli, which also arise from eye-antenna disc, present. Eye portion of disc markedly reduced; no morphogenetic furrow or putative photoreceptor-cell clusters seen; little or no staining with monoclonal antibodies that normally stain presumptive photoreceptor cells.
Summary (Interactive Fly)

transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development - also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate -Retinal axon guidance requires integration of Eya and the JAK/STAT pathway into phosphotyrosine-based signaling circuitries

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\eya for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eya-RA
FBtr0079335
NM_164693
3075
766
eya-RB
FBtr0079334
NM_078768
3320
760
eya-RC
FBtr0306113
NM_001258984
2832
676
Additional Transcript Data and Comments
Reported size (kB)

3.5 (northern blot)

(Bonini et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
eya-PA
FBpp0078964
80.7
766
6.91
NP_723188
AAF52400
eya-PB
FBpp0078963
80.2
760
6.84
NP_523492
AAN10587
eya-PC
FBpp0297250
70.5
676
6.54
NP_001245913
AFH03587
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

766, 760 (aa); 80 (kD)

(Bonini et al., 1993)
Comments

The two proteins encoded by eya differ only in the amino-terminal 19 (or 25) amino acid residues. The eya sequence has no strong resemblance to other proteins in the databases. A polyclonal mouse antiserum was produced against a fusion protein that contains eya sequences common to both proteins.

(Bonini et al., 1993)

One of a couple of products generated by alternative splicing.

(FlyBase, 1992-)
External Data
Subunit Structure (UniProtKB)

Interacts with Dac and So.

(UniProt, Q05201)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eya using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Bonini et al., 1993)
larval stage
morphogenetic furrow | anterior
(Bonini et al., 1993)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 13
Bolwig organ primordium | subset
(Daniel et al., 1999)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 8 -- 9
head mesoderm
(Liu et al., 2009)
trunk mesoderm
(Liu et al., 2009)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 10
embryonic protocerebrum | anterior
(Chang et al., 2001)
visual primordium
(Chang et al., 2001)
dorsal head epidermis
(Chang et al., 2001)
mesoderm | ventral
(Liu et al., 2009)
embryonic stage 10 -- 12
visual primordium | subset
(Daniel et al., 1999)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
stomatogastric nervous system primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 12
visual primordium | restricted
(Biehs et al., 2010)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut sensory structure
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic ventral apodeme
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
larval stage
eye-antennal disc
(Bonini et al., 1993)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
eye-antennal disc
(Bonini et al., 1993)
adult stage
adult head
(Bonini et al., 1993)
Additional Descriptive Data

In stage 12 embryos, eya is expressed in the posterior lobe but not in the anterior lobe of the optic primordium.

(Biehs et al., 2010)

eya and tin are coexpressed in the entire mesoderm at embryonic stage 8 and 9. By stage 10, eya expression is restricted to the ventral mesoderm while tin expression is restricted to the dorsal mesoderm. At later stages, eya is not detected in differentiating muscle.

(Liu et al., 2009)

eya is expressed in a crescent-shaped domain that partially overlaps with the optic lobe (stage 10-12) and Bolwig's organ (stage 10-13).

(Daniel et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye-antennal disc | gradient
(Bonini et al., 1993)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast NB5-6
(Lacin and Truman, 2016)
embryonic stage 11 -- 12
gonadal sheath proper primordium
(Clark et al., 2006)
embryonic stage 13
fat body/gonad primordium
(Starz-Gaiano et al., 2001)
embryonic stage 14 -- 17
apterous-expressing neuron of the lateral cluster of the thorax
(Ulvklo et al., 2012)
embryonic stage 15 -- 17
embryonic thorax | restricted
(Baumgardt et al., 2007)
embryonic stage 15 -- larval stage
Tvb neuron
(Baumgardt et al., 2007)
embryonic stage 17
gonadal sheath proper primordium
(DeFalco et al., 2008)
apterous-expressing neuron of the lateral cluster of the thorax
(Losada-Pérez et al., 2013)
larval stage
neuroblast NB5-6
(Lacin and Truman, 2016)
second instar larval stage
eye-antennal disc | gradient
(Bonini et al., 1993)
eye disc | restricted
(Wang and Sun, 2012)
third instar larval stage
eye-antennal disc | gradient
(Bonini et al., 1993)
presumptive ocellus
(Blanco et al., 2010)
wandering third instar larval stage
eye disc anterior to the morphogenetic furrow
(Bessa et al., 2002)
eye disc posterior to the morphogenetic furrow
(Bessa et al., 2002)
morphogenetic furrow
(Bessa et al., 2002)
adult stage | male
cyst cell of testis
• nucleus
(Fabrizio et al., 2003)
oogenesis & adult stage | female
main body follicle cell
(Johnston et al., 2016, Chang et al., 2013)
adult stage | female & oogenesis
prefollicle cell
(Johnston et al., 2016, Ulmschneider et al., 2016)
follicle stem cell
(Johnston et al., 2016)
oogenesis stage S9 -- S10 & adult stage | female
border follicle cell
(Wang et al., 2007)
adult stage | male & spermatogenesis
spermatogonium
(Zhang et al., 2013)
oogenesis stage S10A
stretch follicle cell
(Levine et al., 2010)
Additional Descriptive Data

eya protein is expressed in follicle stem cells, prefollicle cells, and oocyte associated (main body) follicle cells, but not in interfollicle (stalk) cells, and polar follicle cells.

(Johnston et al., 2016)

eya protein is expressed during oogenesis in prefollicle cells.

(Ulmschneider et al., 2016)

At oogenesis stage S10A, eya is expressed in the nurse cell follicle cells and also marks the leading edge follicle cells.

(Levine et al., 2010)

Expressed in somatic gonadal precursors but not in ensheathing cells in stage 17 embryos.

(DeFalco et al., 2008)

eya protein can be detected in mid to late stage spermatogonial cysts.

(Fabrizio et al., 2003)

eya protein is expressed in the eye disc in a pattern that includes the morphogenetic furrow, the h-expressing pre-proneural region immediately anterior to the morphogenetic furrow, and the cells posterior the morphogenetic furrow.

(Bessa et al., 2002)

eya protein expression is first detected in second instar larvae in the eye portion of the eye-antennal disc. It is observed as a gradient with the posterior and edge regions of the disc showing stronger expression than the central and anterior portions. As the morphogenetic furrow forms, the protein is found in a gradient anterior to it with the strongest expression close to the furrow. Protein expression persists in cells after the furrow passes. Posterior to the furrow, expression is patterned in clusters of developing neurons.

(Bonini et al., 1993)
Marker for
 
border follicle cell
(Wang et al., 2007)
cyst cell of testis
(Sheng et al., 2009)
gonadal sheath proper primordium
(Clark et al., 2006)
prefollicle cell
(Ulmschneider et al., 2016)
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
located_in cytosol
inferred from direct assay
(Xiong et al., 2009)
located_in nucleus
inferred from direct assay
(assigned by UniProt )
(Bonini et al., 1993)
inferred from direct assay
(Dai et al., 2017, Xiong et al., 2009, Fabrizio et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eya in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 65 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 84 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eya
Transgenic constructs containing regulatory region of eya
Aberrations (Deficiencies and Duplications) ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2L)BSC354)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4dpp.blk1
lethal - all die during embryonic stage
lethal - all die during embryonic stage (with eyaE1)
lethal - all die during embryonic stage (with eyaE4)
lethal - all die during embryonic stage (with eyaE7)
lethal - all die during embryonic stage (with eyaE8)
lethal - all die during embryonic stage (with eyaE11)
lethal - all die during embryonic stage (with eyaE12)
lethal - all die during embryonic stage (with eyaE(P)10)
lethal - all die during embryonic stage | partially (with eyaE(P)10)
lethal - all die during embryonic stage | partially (with eyaIR1)
lethal - all die during embryonic stage | recessive
partially lethal | recessive
partially lethal - majority die
partially lethal - majority die, with Df(2L)BSC354/eyacli-IID
partially lethal - majority die (with Df(2L)BSC354), with eyaGRΔPSE
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female fertile
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female sterile
female sterile | recessive
fertile
male sterile
male sterile (with Df(2L)eya10)
Other Phenotypes
Allele
abnormal auditory perception | adult stage
abnormal eclosion rhythm
abnormal neuroanatomy
abnormal neuroanatomy (with Df(2L)eya10)
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | late embryonic stage, with Scer\GAL4wg-MD758
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4GMR.PU
abnormal neuroanatomy | third instar larval stage (with eya2)
abnormal neuroanatomy | third instar larval stage (with eyaA188)
abnormal size | adult stage
abnormal size | adult stage (with eya1)
abnormal size | adult stage (with eya2)
abnormal size | adult stage (with eya3)
abnormal size | adult stage (with eya4)
abnormal size | adult stage (with eya54C2)
abnormal size | adult stage (with eyacli-IID)
abnormal size | adult stage (with eyacs)
abnormal size | adult stage (with eyaD3)
abnormal size | adult stage (with eyaE1)
abnormal size | adult stage (with eyaE4)
abnormal size | adult stage (with eyaE(P)10)
abnormal size | adult stage (with In(2LR)ETD2.2)
abnormal size | adult stage (with T(2;3;4)ETD4.3)
decreased cell number | adult stage | somatic clone
decreased cell number | oogenesis | oogenesis, with Scer\GAL4upd1.PU
decreased occurrence of cell division | embryonic stage | male
decreased occurrence of cell division | oogenesis | oogenesis, with Scer\GAL4hs.PB
increased cell death | larval stage | somatic clone
increased cell death | third instar larval stage
increased cell number | larval stage | somatic clone
increased occurrence of cell division | larval stage | somatic clone
photoperiod response variant
some die during embryonic stage
some die during embryonic stage (with eyaE1)
some die during embryonic stage (with eyaE4)
some die during embryonic stage (with eyaE7)
some die during embryonic stage (with eyaE8)
some die during embryonic stage (with eyaE11)
some die during embryonic stage (with eyaE12)
some die during embryonic stage (with eyaE(P)10)
some die during embryonic stage | partially (with eyaE(P)10)
some die during embryonic stage | partially (with eyaIR1)
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4dpp.blk1
visible
visible, with Df(2L)BSC354/eyacli-IID
visible, with Scer\GAL4Act5C.PU
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4mirr-DE
visible (with Df(2L)BSC354), with eyaGRΔPSE
visible (with eya1)
visible (with eyacli-IID)
visible (with eyaE1)
visible (with eyaE4)
visible (with eyaE7)
visible (with eyaE8)
visible (with eyaE11)
visible (with eyaE12)
visible (with eyaE(P)10)
visible (with eyaIR1)
visible (with eyaIR3)
visible | adult stage
visible | adult stage, with eya1
visible | adult stage, with eyaRB.enh1
visible | adult stage, with eyaRB.enhE
visible | adult stage, with Scer\GAL4ato.3'348
visible | adult stage, with Scer\GAL4ey.PU
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage (with eya1)
visible | adult stage (with eya2)
visible | adult stage (with eya3)
visible | adult stage (with eya4)
visible | adult stage (with eya54C2)
visible | adult stage (with eyacli-IID)
visible | adult stage (with eyacs)
visible | adult stage (with eyaD3)
visible | adult stage (with eyaE1)
visible | adult stage (with eyaE4)
visible | adult stage (with eyaE(P)10)
visible | adult stage (with In(2LR)ETD2.2)
visible | adult stage (with T(2;3;4)ETD4.3)
visible | recessive
visible | recessive | cold sensitive
visible | somatic clone
wild-type
Phenotype manifest in
Allele
adult head, with Scer\GAL4dpp.blk1
adult head & adult cuticle | ectopic | somatic clone
adult subretinal glial cell
antenna, with Scer\GAL4dpp.blk1
antennal disc, with Scer\GAL4dpp.blk1
antennal segment, with Scer\GAL4dpp.blk1
antennal segment & eye | ectopic, with Scer\GAL4dpp.blk1
antenno-maxillary complex | embryonic stage
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
arista, with Scer\GAL4dpp.PH
Bolwig organ
border follicle cell | somatic clone | increased number
cephalopharyngeal skeleton
cone cell | pupal stage, with Df(2L)BSC354/eyacli-IID
cone cell | pupal stage (with Df(2L)BSC354), with eyaGRΔPSE
denticle belt
dorsal oblique muscle (with Df(2L)BSC6)
egg chamber, with Scer\GAL4c306
egg chamber, with Scer\GAL4hs.PB
egg chamber & basement membrane | apical, with Scer\GAL4upd1.PU
embryonic/larval brain | third instar larval stage, with Scer\GAL4GMR.PU
embryonic/larval dorsal trunk
embryonic/larval labral segment sense organ | embryonic stage
embryonic/larval neuron (with Df(2L)eya10)
embryonic/larval optic lobe | somatic clone | third instar larval stage
embryonic/larval somatic muscle (with Df(2L)BSC6)
embryonic brain
embryonic head
embryonic peripheral nervous system & embryonic abdominal segment 9 | lateral
eye
eye, with Df(2L)BSC354/eyacli-IID
eye, with eya1
eye, with eyaRB.enh1
eye, with eyaRB.enhE
eye, with Scer\GAL4Act5C.PU
eye, with Scer\GAL4dpp.PH
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PU
eye (with Df(2L)BSC354), with eyaGRΔPSE
eye (with eya1)
eye (with eya2)
eye (with eya3)
eye (with eya4)
eye (with eya54C2)
eye (with eyacli-IID)
eye (with eyacs)
eye (with eyaD3)
eye (with eyaE1)
eye (with eyaE4)
eye (with eyaE7)
eye (with eyaE8)
eye (with eyaE11)
eye (with eyaE12)
eye (with eyaE(P)10)
eye (with eyaIR1)
eye (with eyaIR3)
eye (with In(2LR)ETD2.2)
eye (with T(2;3;4)ETD4.3)
eye | adult stage, with Scer\GAL4ato.3'348
eye | adult stage, with Scer\GAL4ey.PU
eye | adult stage, with Scer\GAL4GMR.PU
eye | cell autonomous | somatic clone
eye | dorsal, with Scer\GAL4mirr-DE
eye | ectopic, with Scer\GAL4dpp.blk1
eye | ectopic, with Scer\GAL4dpp.blk1, eyaK699Q.UAS.Tag:Myr(v-Src)
eye | ectopic, with Scer\GAL4dpp.blk1, eyaWT.UAS.Tag:Myr(v-Src)
eye | ectopic, with Scer\GAL4dpp.blk1, eyaWT.UAS.Tag:NLS(SV40-largeT)
eye | somatic clone
eye-antennal disc
eye disc
eye disc | somatic clone
eye disc | third instar larval stage
eye disc | third instar larval stage, with Scer\GAL4ato.3'348
eye disc | third instar larval stage, with Scer\GAL4ey.PU
fat body/gonad primordium
follicle cell, with Scer\GAL4hs.PB
germarium (with eya3)
germarium (with eyaE(P)10)
germline cell
germline cell (with eya3)
germline cell (with eyaE(P)10)
germline cell | embryonic stage | male
gonad | embryonic stage (with eya7.42)
gonad | embryonic stage (with eya117.36)
gonadal sheath proper primordium
gonadal sheath proper primordium | male
head, with Scer\GAL4dpp.blk1
head capsule | somatic clone
hypophysis | embryonic stage
interommatidial cell | pupal stage, with Df(2L)BSC354/eyacli-IID
interommatidial cell | pupal stage (with Df(2L)BSC354), with eyaGRΔPSE
lamina
lamina | precursor
lamina | third instar larval stage (with eya2)
lamina | third instar larval stage (with eyaA188)
lamina forming neuroblast
lateral longitudinal muscle 1
lateral transverse muscle (with Df(2L)BSC6)
leg, with Scer\GAL4dpp.blk1
leg & ommatidium | ectopic, with Scer\GAL4dpp.blk1
leg | ectopic, with Scer\GAL4dpp.PH
macrochaeta | ectopic, with Scer\GAL4dpp.PH
medial longitudinal fascicle | late embryonic stage, with Scer\GAL4wg-MD758
metathoracic leg, with Scer\GAL4dpp.blk1
morphogenetic furrow | somatic clone
ocellus
ommatidium
ommatidium, with Scer\GAL4ey.PH
ommatidium | ectopic, with Scer\GAL4dpp.blk1
ommatidium | pupal stage, with Df(2L)BSC354/eyacli-IID
ommatidium | pupal stage (with Df(2L)BSC354), with eyaGRΔPSE
orbital bristle | ectopic | somatic clone
ovariole, with Scer\GAL4c306
photoreceptor cell
photoreceptor cell & axon
photoreceptor cell | somatic clone
photoreceptor cell | third instar larval stage, with Scer\GAL4ato.3'348
photoreceptor cell | third instar larval stage, with Scer\GAL4ey.PU
photoreceptor cell R1 | somatic clone
photoreceptor cell R6 | somatic clone
photoreceptor cell R7 | somatic clone
pigment cell, with Df(2L)BSC354/eyacli-IID
pigment cell (with Df(2L)BSC354), with eyaGRΔPSE
polar follicle cell, with Scer\GAL4upd1.PU
polar follicle cell | ectopic | somatic clone
posterior vertical bristle
presumptive embryonic/larval central nervous system
presumptive embryonic/larval peripheral nervous system
presumptive embryonic salivary gland
primary spermatocyte cyst (with Df(2L)eya10)
retina
rhabdomere, with Df(2L)BSC354/eyacli-IID
rhabdomere (with Df(2L)BSC354), with eyaGRΔPSE
scutellar bristle | increased number, with Scer\GAL4dpp.PH
somatic mesoderm
spermatid (with Df(2L)eya10)
spermatocyte (with Df(2L)eya10)
spermatocyte | cell non-autonomous | somatic clone
stalk follicle cell, with Scer\GAL4hs.PB
ventral acute muscle (with Df(2L)BSC6)
ventral oblique muscle (with Df(2L)BSC6)
visceral mesoderm
visual primordium
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4dpp.PH
wing & ommatidium | ectopic, with Scer\GAL4dpp.blk1
wing hinge, with Scer\GAL4dpp.blk1
wing vein L3, with Scer\GAL4dpp.PH
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\EYA2
10 of 15
Yes
Yes
Hsap\EYA4
9 of 15
No
Yes
Hsap\EYA1
8 of 15
No
Yes
Hsap\EYA3
8 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Eya2
10 of 15
Yes
Yes
 
1  
Mmus\Eya1
9 of 15
No
Yes
 
1  
Mmus\Eya4
9 of 15
No
Yes
Mmus\Eya3
8 of 15
No
Yes
 
1  
Rattus norvegicus (Norway rat) (4)
Rnor\Eya2
7 of 13
Yes
Yes
Rnor\Eya3
5 of 13
No
Yes
Rnor\Eya4
5 of 13
No
Yes
Rnor\Eya1
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\eya3
6 of 12
Yes
Yes
Xtro\eya1
5 of 12
No
Yes
Xtro\eya2
5 of 12
No
Yes
Xtro\eya4
5 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\eya2
8 of 15
Yes
Yes
Drer\eya1
6 of 15
No
Yes
Drer\eya4
5 of 15
No
Yes
Drer\eya3
4 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\eya-1
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\EYA
4 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905V3 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001404
Drosophila simulans
Dsim\GD22568
Drosophila sechellia
Dsec\GM14165
Drosophila erecta
Dere\GG23613
Drosophila yakuba
Dyak\GE18433
Drosophila ananassae
Dana\GF15700
Drosophila pseudoobscura pseudoobscura
Dpse\GA21875
Drosophila persimilis
Dper\GL26097
Drosophila willistoni
Dwil\GK14797
Drosophila virilis
Dvir\GJ14644
Drosophila mojavensis
Dmoj\GI18181
Drosophila grimshawi
Dgri\GH13031
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915051D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018750
Musca domestica
House fly
Mdoa\17026450
Glossina morsitans
Tsetse fly
Gmor\GMOY010099
Mayetiola destructor
Hessian fly
Mdes\Mdes004984
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013010
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005166
Anopheles darlingi
American malaria mosquito
Adar\ADAC006807
Anopheles gambiae
Malaria mosquito
Agam\AGAP008726
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004824
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004825
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03CD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004453
Danaus plexippus
Monarch butterfly
Dple\DPOGS213428-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016806
Apis florea
Little honeybee
Aflo\2357401588
Apis mellifera
Western honey bee
Amel\GB54835
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18789
Bombus terrestris
Buff-tailed bumblebee
Bter\15203548
Linepithema humile
Argentine ant
Lhum\LH19009
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003052
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012749
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10591
Tribolium castaneum
Red flour beetle
Tcas\clift
Pediculus humanus
Human body louse
Phum\PHUM433110
Rhodnius prolixus
Kissing bug
Rpro\RPRC011951
Cimex lectularius
Bed bug
Clec\CLEC012920
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008185
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06547
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0398 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005305
Strigamia maritima
European centipede
Smar\SMAR013603
Strigamia maritima
European centipede
Smar\SMAR014932
Ixodes scapularis
Black-legged tick
Isca\ISCW015472
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73810.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g14670
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_204955
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04YD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Eya
Ciona intestinalis
Vase tunicate
Cint\LOC101243276
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000000777
Gallus gallus
Domestic chicken
Ggal\EYA4
Gallus gallus
Domestic chicken
Ggal\EYA1
Gallus gallus
Domestic chicken
Ggal\EYA2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
EYA2; EYA transcriptional coactivator and phosphatase 2
10 of 15
601654
      EYA4; EYA transcriptional coactivator and phosphatase 4
      9 of 15
      603550
      EYA1; EYA transcriptional coactivator and phosphatase 1
      8 of 15
      601653
      EYA3; EYA transcriptional coactivator and phosphatase 3
      8 of 15
      601655
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Dmel gene
          Ortholog showing functional complementation
          Supporting References
          eya
          Mmus\Eya1
          (Bui et al., 2000)
          eya
          Mmus\Eya2
          (Bui et al., 2000, Bonini et al., 1997)
          eya
          Mmus\Eya3
          (Bui et al., 2000)
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          eya
          anti tag coimmunoprecipitation, anti tag western blot
          (Mutsuddi et al., 2005)
          eya - Abd-B
          bimolecular fluorescence complementation, fluorescence microscopy
          (Baëza et al., 2015)
          eya - Abl
          protein kinase assay, autoradiography
          (Xiong et al., 2009)
          eya - IKKβ
          anti tag coimmunoprecipitation, anti tag western blot
          (Liu et al., 2012)
          eya - Optix
          anti tag coimmunoprecipitation, anti tag western blot
          (Anderson et al., 2012)
          eya - Rel
          anti tag coimmunoprecipitation, anti tag western blot
          (Liu et al., 2012)
          eya - Scr
          bimolecular fluorescence complementation, fluorescence microscopy
          (Baëza et al., 2015)
          eya - Socs36E
          anti tag coimmunoprecipitation, anti tag western blot
          (Hoi et al., 2016)
          eya - Socs44A
          anti tag coimmunoprecipitation, anti tag western blot
          (Hoi et al., 2016)
          eya - abd-A
          bimolecular fluorescence complementation, fluorescence microscopy
          (Bischof et al., 2018, Baëza et al., 2015)
          eya - cg
          two hybrid, pull down, western blot
          (Davis and Rebay, 2017)
          eya - dac
          anti tag coimmunoprecipitation, anti tag western blot
          (Jin and Mardon, 2016)
          eya - ey
          anti tag coimmunoprecipitation, anti tag western blot
          (Jin and Mardon, 2016)
          eya - gro
          pull down, autoradiography
          (Goldstein et al., 2005)
          eya - hop
          anti tag coimmunoprecipitation, anti tag western blot
          (Hoi et al., 2016)
          eya - nmo
          enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
          (Morillo et al., 2012)
          eya - so
          two hybrid, anti tag coimmunoprecipitation, western blot, anti tag western blot, pull down
          (Davis and Rebay, 2017, Jin and Mardon, 2016, Anderson et al., 2012, Kenyon et al., 2005, Mutsuddi et al., 2005)
          eya - tim
          anti tag coimmunoprecipitation, anti tag western blot
          (Abrieux et al., 2020)
          RNA-protein
          Physical Interaction
          Assay
          References
          eya - Tis11
          pull down, anti tag western blot
          (Yeh et al., 2012)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          eya
          suppressible
          Abl
          (Xiong et al., 2009)
          eya
          enhanceable
          Abl
          (Xiong et al., 2009)
          eya
          enhanceable
          ap
          (Stratmann et al., 2019)
          eya
          suppressible
          Cap-H2
          (Tian et al., 2019)
          eya
          enhanceable
          dac
          (Tavsanli et al., 2004)
          eya
          suppressible
          dac
          (Hsiao et al., 2001)
          eya
          suppressible
          E(z)
          (Tian et al., 2019)
          eya
          suppressible
          Egfr
          (Hsiao et al., 2001)
          eya
          enhanceable
          Pc
          (Tian et al., 2019)
          eya
          suppressible
          Pc
          (Tian et al., 2019)
          eya
          suppressible
          rl
          (Hsiao et al., 2001)
          eya
          enhanceable
          rl
          (Hsiao et al., 2001)
          eya
          enhanceable
          so
          (Pignoni et al., 1997)
          eya
          suppressible
          so
          (Weasner et al., 2016, Hsiao et al., 2001)
          dpp|ey|eya
          enhanceable
          so
          (Pappu et al., 2003)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Abl
          enhanceable
          eya
          (Xiong et al., 2009)
          aop
          enhanceable
          eya
          (Rebay et al., 2000)
          ap
          enhanceable
          eya
          (Stratmann et al., 2019)
          cry
          enhanceable
          eya
          (Rieger et al., 2006)
          CtBP
          enhanceable
          eya
          (Hoang et al., 2010)
          dac
          enhanceable
          eya
          (Tavsanli et al., 2004, Bui et al., 2000, Chen et al., 1997)
          DNaseII
          suppressible
          eya
          (Liu et al., 2012)
          dpp
          suppressible
          eya
          (Curtiss and Mlodzik, 2000)
          ey
          enhanceable
          eya
          (Chen et al., 1999, Bonini et al., 1997)
          ey
          suppressible
          eya
          (Bonini et al., 1997)
          Lmx1a
          suppressible
          eya
          (Wang et al., 2016)
          Mad
          suppressible
          eya
          (Curtiss and Mlodzik, 2000)
          nej
          enhanceable
          eya
          (Anderson et al., 2005)
          Psn
          enhanceable
          eya
          (Mahoney et al., 2006)
          Raf
          enhanceable
          eya
          (Rebay et al., 2000)
          Ras85D
          enhanceable
          eya
          (Rebay et al., 2000)
          Ras85D
          suppressible
          eya
          (Rebay et al., 2000)
          smo
          suppressible
          dpp|eya
          (Pappu et al., 2003)
          smo
          suppressible
          eya|so
          (Pappu et al., 2003)
          so
          enhanceable
          eya
          (Anderson et al., 2014)
          External Data
          Subunit Structure (UniProtKB)
          Interacts with Dac and So.
          (UniProt, Q05201 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-21
          Cytogenetic map
          26E1-26E2
          Sequence location
          2L:6,527,447..6,546,976 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          26E1-26E2
          Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          26E-26F
          (Zimmerman, 1999.9.29)
          26E-26E
          (determined by in situ hybridisation)
          (Bonini et al., 1993, Bonini et al., 1991)
          Experimentally Determined Recombination Data
          Location

          2-21

          (FlyBase, 2016)

          2-21.1

          (Comeron et al., 2012)

          2-17

          (Tearle and Nusslein-Volhard, 1987)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (23)
          Genomic Clones (22)
          cDNA Clones (21)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Bonini et al., 1993)
          Commercially Available Antibodies
           
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: eya ey-2

          (Eissenberg, 2006.2.5)

          Source for merge of: eya BcDNA:LD16029

          (FlyBase, 1996-)
          Additional comments

          Source for merge of eya BcDNA:LD16029 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)
          Other Comments

          eya is required for normal cone cell and pigment cell development.

          (Karandikar et al., 2014)

          eya induces expression of dac.

          (Anderson et al., 2006)

          eya is a key repressor of polar follicle cell fate during oogenesis.

          (Bai and Montell, 2002)

          Bolwig's organ formation is governed by ato, the expression of which is under the control of hh, eya and so.

          (Suzuki and Saigo, 2000)

          so and eya are two mediators of the eye inducing activity of ey. ey appears to induce the initial expression of so and eya in the eye disc. so and eya then participate in a positive feedback loop that regulates the expression of all three genes. In the embryonic head, however, so acts in parallel to ey and toy. The epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.

          (Halder et al., 1998)

          Mutations in one region of eya cause embryonic lethality, whereas mutations throughout the gene cause defects in eye development.

          (Leiserson et al., 1998)

          eya is required for both fat body and gonadal mesoderm development in the embryo.

          (Moore et al., 1998)

          eya is essential for ey function, and can itself serve as a master control gene for eye formation.

          (Bonini et al., 1997)

          dac and eya act synergistically to induce ectopic retinal development and positively regulate the expression of each other.

          (Chen et al., 1997)

          so and eya regulate common steps in eye development including cell proliferation, patterning and neuronal development.

          (Pignoni et al., 1997)

          In addition to a role in eye development, eya alleles can be embryonic lethal, female sterile or affect the development of the ocelli and regions of the adult brain. The eye-specific alleles undergo transvection and appear to define sequences required for eye-specific expression of the gene.

          (Bonini, 1995)

          eya is required at an early stage of gonadogenesis, the specification of gonadal precursors.

          (Boyle and DiNardo, 1995)

          Alleles of eya that disrupt coalescence of the embryonic gonad have been identified in a screen for mutations disrupting pole cell migration and gonad formation.

          (Moore et al., 1995)

          Interaction occurs among certain alleles of eya, the interactions are sensitive to transvection disrupting rearrangements and are dependent on normal z function.

          (Leiserson et al., 1994)

          Complementation analysis with lethal alleles suggests 'clift' and 'eya' are allelic though the eye function, in part, is independently mutable.

          (Bonini et al., 1993)

          'clift' activity is required for the survival of eye progenitor cells at a critical stage in morphogenesis. Molecular analysis identifies a nuclear protein expressed in progenitor cells prior to differentiation. Alleles with partial eye development have abnormally high cell death anterior to the furrow.

          (Bonini et al., 1993)

          Adult phenotype is no or reduced eye, eye disc phenotype is a small disc with no or few clusters apparent due to precursor cell defects.

          (Renfranz and Benzer, 1989)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 57 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DPiM - Drosophila Protein interaction map
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (26)
          Reported As
          Symbol Synonym
          24582246
          (Burroughs et al., 2006)
          BcDNA:LD16029
          CG9554
          (Datta et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Klebes et al., 2005)
          CLI
          (Jemc et al., 2012)
          CLIFT
          (Van Doren et al., 2002)
          Clift
          (Bialistoky et al., 2019)
          EY2-1
          (Rebay et al., 2000)
          EYA
          (Monahan and Starz-Gaiano, 2013, Jemc et al., 2012, Whitworth et al., 2012, Casper et al., 2011, Datta et al., 2009, DeFalco et al., 2008, Erclik et al., 2008, Prince et al., 2008, Yamada et al., 2008, Jemc and Rebay, 2007, Xiong et al., 2007, Hempel and Oliver, 2006)
          Eya
          (Sênos Demarco et al., 2020, Wang et al., 2020, La Marca et al., 2019, Davis and Rebay, 2018, Kim et al., 2018, Sawant et al., 2018, Dai et al., 2017, Davis and Rebay, 2017, Davis and Rebay, 2017, Bandyopadhyay et al., 2016, Fried et al., 2016, Kotov et al., 2016, Mbodj et al., 2016, Monahan and Starz-Gaiano, 2016, Ulmschneider et al., 2016, Wang et al., 2016, Baëza et al., 2015, Hatzihristidis et al., 2015, Reilly et al., 2015, Smendziuk et al., 2015, Yu et al., 2015, Lin et al., 2014, Tanaka-Matakatsu et al., 2014, Ettensohn, 2013, Ishitani and Ishitani, 2013, Koontz et al., 2013, Anderson et al., 2012, Gomez et al., 2012, Morillo Prado et al., 2012, Nfonsam et al., 2012, Rincon-Arano et al., 2012, Ulvklo et al., 2012, Wang and Sun, 2012, Yu et al., 2012, Zoller and Schulz, 2012, Baker and Firth, 2011, Benito-Sipos et al., 2011, Charlton-Perkins et al., 2011, Datta et al., 2011, Hwang and Rulifson, 2011, Lynch and Wagner, 2011, Xu et al., 2011, Zhang et al., 2011, Kugler et al., 2010, Pines et al., 2010, Singh et al., 2010, Bessa et al., 2009, Eade and Allan, 2009, Liu et al., 2009, Sheng et al., 2009, Shyu et al., 2009, Xiong et al., 2009, Nusinow et al., 2008, Siera and Cline, 2008, Tian and Deng, 2008, Wang et al., 2008, Wrobel et al., 2008, Xiong et al., 2008, Assa-Kunik et al., 2007, Clark et al., 2007, Curtiss et al., 2007, Grammont, 2007, Kitadate et al., 2007, Penn and Schedl, 2007, Sun and Deng, 2007, Wang et al., 2007, Wang et al., 2007, Yoshioka et al., 2007, Bras-Pereira et al., 2006, Poulton and Deng, 2006, Siddall et al., 2006, Goldstein et al., 2005, Zhang et al., 2005, Dominguez et al., 2004, Kenyon et al., 2001, Kirby et al., 2001, Starz-Gaiano et al., 2001)
          Eyes absent
          (Jin et al., 2016)
          cli
          (Schlichting et al., 2019, Bachleitner et al., 2007, Rieger et al., 2006, Li et al., 2003, Rieger et al., 2003, McNabb and Truman, 2001, Boyle et al., 1997, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)
          cli/eya
          (Santos and Lehmann, 2004)
          dEYA
          (Liu et al., 2012)
          del1
          (Weyers et al., 2011)
          eay
          (Lee et al., 2007)
          ey-2
          (Eissenberg and Ryerse, 1991)
          eya
          (Casares and McGregor, 2021, Creed et al., 2020, Nair et al., 2020, Rust et al., 2020, Zhang et al., 2020, Chang et al., 2019, Gaspar et al., 2019, Hao et al., 2019, Lo et al., 2019, Nash et al., 2019, Story et al., 2019, Stratmann et al., 2019, Bischof et al., 2018, Kamath et al., 2018, Kumar, 2018, Palmer et al., 2018, Sarkar et al., 2018, Yeung et al., 2018, Zhu et al., 2018, Aggarwal et al., 2017, Davis and Rebay, 2017, Davis et al., 2017, Dove et al., 2017, Stratmann and Thor, 2017, Aggarwal et al., 2016, Apitz and Salecker, 2016, Dubois et al., 2016, Du et al., 2016, Hoi et al., 2016, Jin and Mardon, 2016, Jin et al., 2016, Jin et al., 2016, Sarov et al., 2016, Stratmann et al., 2016, Wang et al., 2016, Weasner et al., 2016, Yu et al., 2016, Bivik et al., 2015, de Taffin et al., 2015, Doggett et al., 2015, Glassford et al., 2015, Wittkorn et al., 2015, Yu et al., 2015, Anderson et al., 2014, Blaquiere et al., 2014, Feng et al., 2014, Ghavi-Helm et al., 2014, Karandikar et al., 2014, Piñeiro et al., 2014, Ramin et al., 2014, Rosenbaum et al., 2014, Sopko et al., 2014, Zhou et al., 2014, Atkins et al., 2013, Harbison et al., 2013, Ibrahim et al., 2013, Jin et al., 2013, Li et al., 2013, Marinho et al., 2013, Moran et al., 2013, Naval-Sánchez et al., 2013, Pancratov et al., 2013, Slattery et al., 2013, Southall et al., 2013, Tadjuidje and Hegde, 2013, Weasner and Kumar, 2013, Zhang et al., 2013, Aumiller et al., 2012, Frizzell et al., 2012, Jusiak et al., 2012, Liu et al., 2012, Manning et al., 2012, Morillo et al., 2012, Senthilan et al., 2012, Whitworth et al., 2012, Yeh et al., 2012, Brockmann et al., 2011, Datta et al., 2011, Gehring, 2011, Napoletano et al., 2011, Okegbe and DiNardo, 2011, Rotkopf et al., 2011, Sun et al., 2011, Weyers et al., 2011, Aerts et al., 2010, Biehs et al., 2010, Blanco et al., 2010, Karlsson et al., 2010, Kazemian et al., 2010, Levine et al., 2010, Lopes and Casares, 2010, Losada-Pérez et al., 2010, Mecklenburg et al., 2010, Monk et al., 2010, Morrison and Halder, 2010, Oros et al., 2010, Popov et al., 2010, Roignant et al., 2010, Salzer and Kumar, 2010, Salzer et al., 2010, Baumgardt et al., 2009, Blanco et al., 2009, Firth and Baker, 2009, Hazelett et al., 2009, Moressis et al., 2009, Nanda et al., 2009, Salzer and Kumar, 2009, Starz-Gaiano et al., 2009, Sung et al., 2009, Weasner et al., 2009, Anderson and Kumar, 2008, Baumgardt et al., 2008, Braid and Verheyen, 2008, Brás-Pereira and Casares, 2008, Chen et al., 2008, Duong et al., 2008, Hanai et al., 2008, Hayashi et al., 2008, Kim et al., 2008, Leatherman and DiNardo, 2008, McKay et al., 2008, McNabb and Truman, 2008, Melicharek et al., 2008, Morillo et al., 2008, Salzer and Kumar, 2008, Tanaka-Matakatsu and Du, 2008, Ulvklo et al., 2008, Umezaki and Tomioka, 2008, Yasugi et al., 2008, Aerts et al., 2007, Baumgardt et al., 2007, Baumgardt et al., 2007, Christensen et al., 2007.10.29, Dietzl et al., 2007, Fic et al., 2007, Haerty et al., 2007, Hempel and Oliver, 2007, Herrero et al., 2007, Jemc and Rebay, 2007, Jones, 2007, Kumar and Datta, 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Mecklenburg, 2007, Meignin et al., 2007, Nilsson et al., 2007, Polesello and Tapon, 2007, Sprecher et al., 2007, Tanentzapf et al., 2007, Wang et al., 2007, Weasner et al., 2007, Zeitlinger et al., 2007, Anderson et al., 2006, Borghese et al., 2006, Clark et al., 2006, Friedrich, 2006, Le Bras and Van Doren, 2006, Mahoney et al., 2006, Ostrin et al., 2006, Philippakis et al., 2006, Wijnen et al., 2006, Zhang et al., 2006, Choi et al., 2005, Chotard et al., 2005, Katsuyama et al., 2005, Roederer et al., 2005, Sarfare et al., 2005, Wawersik et al., 2005, Zimmerman et al., 2004, Fabrizio et al., 2003, Silver et al., 2003, Bonini et al., 1998)
          eyes absent
          (Aggarwal et al., 2016)
          Name Synonyms
          Clift
          (Jemc et al., 2012)
          Eye absent
          (Zhang and Pignoni, 2008)
          Eyes Absent
          (Bandyopadhyay et al., 2016, Monahan and Starz-Gaiano, 2016, Reilly et al., 2015, Whitworth et al., 2012, Salzer and Kumar, 2010, DeFalco et al., 2008, Jemc and Rebay, 2007, Wang et al., 2007, Xiong et al., 2007)
          Eyes absent
          (Davis and Rebay, 2017, Saadin and Starz-Gaiano, 2016, Ulmschneider et al., 2016, Baëza et al., 2015, Jemc et al., 2012, Benito-Sipos et al., 2011, Xu et al., 2011, Kugler et al., 2010, Losada-Pérez et al., 2010, Pines et al., 2010, Baumgardt et al., 2009, Xiong et al., 2009, Morillo et al., 2008, Prince et al., 2008, Tian and Deng, 2008, Clark et al., 2007, Hempel and Oliver, 2007, Kitadate et al., 2007, Penn and Schedl, 2007, Wang et al., 2007, Borghese et al., 2006, Goldstein et al., 2005, Zhang et al., 2005, Kenyon et al., 2001)
          Eyes-Absent
          (Kiger et al., 2000)
          Eyes-absent
          (Xu et al., 2011)
          clift
          (Li et al., 2003, Deshpande et al., 2001, Boyle et al., 1997, Nusslein-Volhard et al., 1984)
          delayed gonad formation 1
          (Weyers et al., 2011)
          eyeless 2
          eyes absent
          (Aggarwal et al., 2017, Dubois et al., 2016, Wang et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Head et al., 2015, Piñeiro et al., 2014, Rosenbaum et al., 2014, Harbison et al., 2013, Marinho et al., 2013, Naval-Sánchez et al., 2013, Slattery et al., 2013, Southall et al., 2013, Tadjuidje and Hegde, 2013, Weasner and Kumar, 2013, Frizzell et al., 2012, Van Bortle et al., 2012, Yeh et al., 2012, Gehring, 2011, Okegbe and DiNardo, 2011, Rotkopf et al., 2011, Sun et al., 2011, Weyers et al., 2011, Blanco et al., 2010, Levine et al., 2010, Lopes and Casares, 2010, Mecklenburg et al., 2010, Oros et al., 2010, Salzer et al., 2010, Blanco et al., 2009, Liu et al., 2009, Sheng et al., 2009, Sung et al., 2009, Weasner et al., 2009, Brás-Pereira and Casares, 2008, Leatherman and DiNardo, 2008, McKay et al., 2008, McNabb and Truman, 2008, Ulvklo et al., 2008, Yasugi et al., 2008, Fic et al., 2007, Herrero et al., 2007, Jemc and Rebay, 2007, Jones, 2007, Kumar and Datta, 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Mecklenburg, 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Fernald, 2006, Le Bras and Van Doren, 2006, Ostrin et al., 2006, Roederer et al., 2005, Wawersik et al., 2005, Zimmerman et al., 2004, Fabrizio et al., 2003, Rieger et al., 2003, Silver et al., 2003, Bonini et al., 1998)
          eyes-absent
          (Lee et al., 2007)
          Secondary FlyBase IDs
          • FBgn0000623
          • FBgn0004612
          • FBgn0063692
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (598)