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General Information
Symbol
Dmel\eya
Species
D. melanogaster
Name
eyes absent
Annotation Symbol
CG9554
Feature Type
FlyBase ID
FBgn0000320
Gene Model Status
Stock Availability
Gene Summary
eyes absent (eya) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by ey, dac, and so. The product of eya regulates eye, gonad, and brain development as well as axon pathfinding. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
Also Known As

cli, clift, ey-2

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:6,527,447..6,546,976 [-]
Recombination map
2-21
RefSeq locus
NT_033779 REGION:6527447..6546976
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (36 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
Biological Process (28 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
involved_in gonad development
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:DNaseII; FB:FBgn0000477
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
inferred from mutant phenotype
inferred from mutant phenotype
inferred from physical interaction with FLYBASE:so; FB:FBgn0003460
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in spermatogenesis
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Abl; FB:FBgn0000017
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
located_in cytosol
inferred from direct assay
located_in nucleus
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000022641
(assigned by GO_Central )
Protein Family (UniProt)
Belongs to the HAD-like hydrolase superfamily. EYA family. (Q05201)
Summaries
Gene Snapshot
eyes absent (eya) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by ey, dac, and so. The product of eya regulates eye, gonad, and brain development as well as axon pathfinding. [Date last reviewed: 2018-09-06]
Gene Group (FlyBase)
EYA FAMILY PROTEIN TYROSINE PHOSPHATASES -
Eyes-Absent (EYA) family phosphatases function as a protein tyrosine phosphatase and as a transcription factor, with EYA itself and RNA polymerase II CTD repeats as targets. They are members of the Haloacid Dehalogenase (HAD) superfamily that require a metal for catalytic activity and use aspartic acid as a nucleophile instead of the classic cysteine residue. Only one member is found in Drosophila - eya is involved in numerous processes including the regulation of the anti-DNA immune response, retinal determination, spermatocyte development and oogenesis. (Adapted from FBrf0228712 and FBrf0227974.)
Protein Function (UniProtKB)
Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity (PubMed:14628052, PubMed:14628053). The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development (PubMed:9428512, PubMed:9428513). Required for the survival of eye progenitor cells at a critical stage in morphogenesis (PubMed:8431945).
(UniProt, Q05201)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
cli: clift (C. Nusslein-Volhard)
Embryonic lethal. Defect in head involution. No segmental movements. Shows abdominal transformations in combination with Pc-like mutants.
eya: eyes absent
Eye facets completely absent in strong alleles; other aspects of head development appear normal; antennae and ocelli, which also arise from eye-antenna disc, present. Eye portion of disc markedly reduced; no morphogenetic furrow or putative photoreceptor-cell clusters seen; little or no staining with monoclonal antibodies that normally stain presumptive photoreceptor cells.
Summary (Interactive Fly)

transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development - also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate -Retinal axon guidance requires integration of Eya and the JAK/STAT pathway into phosphotyrosine-based signaling circuitries

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\eya for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079335
3075
766
FBtr0079334
3320
760
FBtr0306113
2832
676
Additional Transcript Data and Comments
Reported size (kB)

3.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0078964
80.7
766
6.91
FBpp0078963
80.2
760
6.84
FBpp0297250
70.5
676
6.54
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

766, 760 (aa); 80 (kD)

Comments

The two proteins encoded by eya differ only in the amino-terminal 19 (or 25) amino acid residues. The eya sequence has no strong resemblance to other proteins in the databases. A polyclonal mouse antiserum was produced against a fusion protein that contains eya sequences common to both proteins.

One of a couple of products generated by alternative splicing.

External Data
Subunit Structure (UniProtKB)

Interacts with Dac and So.

(UniProt, Q05201)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eya using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

In stage 12 embryos, eya is expressed in the posterior lobe but not in the anterior lobe of the optic primordium.

eya and tin are coexpressed in the entire mesoderm at embryonic stage 8 and 9. By stage 10, eya expression is restricted to the ventral mesoderm while tin expression is restricted to the dorsal mesoderm. At later stages, eya is not detected in differentiating muscle.

eya is expressed in a crescent-shaped domain that partially overlaps with the optic lobe (stage 10-12) and Bolwig's organ (stage 10-13).

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

eya protein is expressed in follicle stem cells, prefollicle cells, and oocyte associated (main body) follicle cells, but not in interfollicle (stalk) cells, and polar follicle cells.

eya protein is expressed during oogenesis in prefollicle cells.

At oogenesis stage S10A, eya is expressed in the nurse cell follicle cells and also marks the leading edge follicle cells.

Expressed in somatic gonadal precursors but not in ensheathing cells in stage 17 embryos.

eya protein can be detected in mid to late stage spermatogonial cysts.

eya protein is expressed in the eye disc in a pattern that includes the morphogenetic furrow, the h-expressing pre-proneural region immediately anterior to the morphogenetic furrow, and the cells posterior the morphogenetic furrow.

eya protein expression is first detected in second instar larvae in the eye portion of the eye-antennal disc. It is observed as a gradient with the posterior and edge regions of the disc showing stronger expression than the central and anterior portions. As the morphogenetic furrow forms, the protein is found in a gradient anterior to it with the strongest expression close to the furrow. Protein expression persists in cells after the furrow passes. Posterior to the furrow, expression is patterned in clusters of developing neurons.

Marker for
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
located_in cytosol
inferred from direct assay
located_in nucleus
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eya in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 65 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 84 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eya
Transgenic constructs containing regulatory region of eya
Aberrations (Deficiencies and Duplications) ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
adult head & adult cuticle | ectopic | somatic clone
antennal segment & eye | ectopic, with Scer\GAL4dpp.blk1
egg chamber & basement membrane | apical, with Scer\GAL4upd1.PU
embryonic peripheral nervous system & embryonic abdominal segment 9 | lateral
eye (with eyaE7)
eye (with eyaE8)
leg & ommatidium | ectopic, with Scer\GAL4dpp.blk1
photoreceptor cell & axon
wing & ommatidium | ectopic, with Scer\GAL4dpp.blk1
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
9 of 15
No
Yes
8 of 15
No
Yes
8 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
 
1  
9 of 15
No
Yes
 
1  
9 of 15
No
Yes
8 of 15
No
Yes
 
1  
Rattus norvegicus (Norway rat) (4)
7 of 13
Yes
Yes
5 of 13
No
Yes
5 of 13
No
Yes
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
6 of 12
Yes
Yes
5 of 12
No
Yes
5 of 12
No
Yes
5 of 12
No
Yes
Danio rerio (Zebrafish) (4)
8 of 15
Yes
Yes
6 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
11 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
4 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905V3 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915051D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03CD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0398 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04YD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Interacts with Dac and So.
(UniProt, Q05201 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-21
Cytogenetic map
Sequence location
2L:6,527,447..6,546,976 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
26E1-26E2
Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
26E-26E
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (23)
Genomic Clones (22)
cDNA Clones (21)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of

Source for merge of: eya ey-2

Source for merge of: eya BcDNA:LD16029

Additional comments

Source for merge of eya BcDNA:LD16029 was a shared cDNA ( date:030728 ).

Other Comments

eya is required for normal cone cell and pigment cell development.

eya induces expression of dac.

eya is a key repressor of polar follicle cell fate during oogenesis.

Bolwig's organ formation is governed by ato, the expression of which is under the control of hh, eya and so.

so and eya are two mediators of the eye inducing activity of ey. ey appears to induce the initial expression of so and eya in the eye disc. so and eya then participate in a positive feedback loop that regulates the expression of all three genes. In the embryonic head, however, so acts in parallel to ey and toy. The epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila.

Mutations in one region of eya cause embryonic lethality, whereas mutations throughout the gene cause defects in eye development.

eya is required for both fat body and gonadal mesoderm development in the embryo.

eya is essential for ey function, and can itself serve as a master control gene for eye formation.

dac and eya act synergistically to induce ectopic retinal development and positively regulate the expression of each other.

so and eya regulate common steps in eye development including cell proliferation, patterning and neuronal development.

In addition to a role in eye development, eya alleles can be embryonic lethal, female sterile or affect the development of the ocelli and regions of the adult brain. The eye-specific alleles undergo transvection and appear to define sequences required for eye-specific expression of the gene.

eya is required at an early stage of gonadogenesis, the specification of gonadal precursors.

Alleles of eya that disrupt coalescence of the embryonic gonad have been identified in a screen for mutations disrupting pole cell migration and gonad formation.

Interaction occurs among certain alleles of eya, the interactions are sensitive to transvection disrupting rearrangements and are dependent on normal z function.

Complementation analysis with lethal alleles suggests 'clift' and 'eya' are allelic though the eye function, in part, is independently mutable.

'clift' activity is required for the survival of eye progenitor cells at a critical stage in morphogenesis. Molecular analysis identifies a nuclear protein expressed in progenitor cells prior to differentiation. Alleles with partial eye development have abnormally high cell death anterior to the furrow.

Adult phenotype is no or reduced eye, eye disc phenotype is a small disc with no or few clusters apparent due to precursor cell defects.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 57 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (26)
Reported As
Symbol Synonym
BcDNA:LD16029
Eya
(Sênos Demarco et al., 2020, Wang et al., 2020, La Marca et al., 2019, Davis and Rebay, 2018, Kim et al., 2018, Sawant et al., 2018, Dai et al., 2017, Davis and Rebay, 2017, Davis and Rebay, 2017, Bandyopadhyay et al., 2016, Fried et al., 2016, Kotov et al., 2016, Mbodj et al., 2016, Monahan and Starz-Gaiano, 2016, Ulmschneider et al., 2016, Wang et al., 2016, Baëza et al., 2015, Hatzihristidis et al., 2015, Reilly et al., 2015, Smendziuk et al., 2015, Yu et al., 2015, Lin et al., 2014, Tanaka-Matakatsu et al., 2014, Ettensohn, 2013, Ishitani and Ishitani, 2013, Koontz et al., 2013, Anderson et al., 2012, Gomez et al., 2012, Morillo Prado et al., 2012, Nfonsam et al., 2012, Rincon-Arano et al., 2012, Ulvklo et al., 2012, Wang and Sun, 2012, Yu et al., 2012, Zoller and Schulz, 2012, Baker and Firth, 2011, Benito-Sipos et al., 2011, Charlton-Perkins et al., 2011, Datta et al., 2011, Hwang and Rulifson, 2011, Lynch and Wagner, 2011, Xu et al., 2011, Zhang et al., 2011, Kugler et al., 2010, Pines et al., 2010, Singh et al., 2010, Bessa et al., 2009, Eade and Allan, 2009, Liu et al., 2009, Sheng et al., 2009, Shyu et al., 2009, Xiong et al., 2009, Nusinow et al., 2008, Siera and Cline, 2008, Tian and Deng, 2008, Wang et al., 2008, Wrobel et al., 2008, Xiong et al., 2008, Assa-Kunik et al., 2007, Clark et al., 2007, Curtiss et al., 2007, Grammont, 2007, Kitadate et al., 2007, Penn and Schedl, 2007, Sun and Deng, 2007, Wang et al., 2007, Wang et al., 2007, Yoshioka et al., 2007, Bras-Pereira et al., 2006, Poulton and Deng, 2006, Siddall et al., 2006, Goldstein et al., 2005, Zhang et al., 2005, Dominguez et al., 2004, Kenyon et al., 2001, Kirby et al., 2001, Starz-Gaiano et al., 2001)
Eyes absent
eya
(Casares and McGregor, 2021, Creed et al., 2020, Nair et al., 2020, Rust et al., 2020, Zhang et al., 2020, Chang et al., 2019, Gaspar et al., 2019, Hao et al., 2019, Lo et al., 2019, Nash et al., 2019, Story et al., 2019, Stratmann et al., 2019, Bischof et al., 2018, Kamath et al., 2018, Kumar, 2018, Palmer et al., 2018, Sarkar et al., 2018, Yeung et al., 2018, Zhu et al., 2018, Aggarwal et al., 2017, Davis and Rebay, 2017, Davis et al., 2017, Dove et al., 2017, Stratmann and Thor, 2017, Aggarwal et al., 2016, Apitz and Salecker, 2016, Dubois et al., 2016, Du et al., 2016, Hoi et al., 2016, Jin and Mardon, 2016, Jin et al., 2016, Jin et al., 2016, Sarov et al., 2016, Stratmann et al., 2016, Wang et al., 2016, Weasner et al., 2016, Yu et al., 2016, Bivik et al., 2015, de Taffin et al., 2015, Doggett et al., 2015, Glassford et al., 2015, Wittkorn et al., 2015, Yu et al., 2015, Anderson et al., 2014, Blaquiere et al., 2014, Feng et al., 2014, Ghavi-Helm et al., 2014, Karandikar et al., 2014, Piñeiro et al., 2014, Ramin et al., 2014, Rosenbaum et al., 2014, Sopko et al., 2014, Zhou et al., 2014, Atkins et al., 2013, Harbison et al., 2013, Ibrahim et al., 2013, Jin et al., 2013, Li et al., 2013, Marinho et al., 2013, Moran et al., 2013, Naval-Sánchez et al., 2013, Pancratov et al., 2013, Slattery et al., 2013, Southall et al., 2013, Tadjuidje and Hegde, 2013, Weasner and Kumar, 2013, Zhang et al., 2013, Aumiller et al., 2012, Frizzell et al., 2012, Jusiak et al., 2012, Liu et al., 2012, Manning et al., 2012, Morillo et al., 2012, Senthilan et al., 2012, Whitworth et al., 2012, Yeh et al., 2012, Brockmann et al., 2011, Datta et al., 2011, Gehring, 2011, Napoletano et al., 2011, Okegbe and DiNardo, 2011, Rotkopf et al., 2011, Sun et al., 2011, Weyers et al., 2011, Aerts et al., 2010, Biehs et al., 2010, Blanco et al., 2010, Karlsson et al., 2010, Kazemian et al., 2010, Levine et al., 2010, Lopes and Casares, 2010, Losada-Pérez et al., 2010, Mecklenburg et al., 2010, Monk et al., 2010, Morrison and Halder, 2010, Oros et al., 2010, Popov et al., 2010, Roignant et al., 2010, Salzer and Kumar, 2010, Salzer et al., 2010, Baumgardt et al., 2009, Blanco et al., 2009, Firth and Baker, 2009, Hazelett et al., 2009, Moressis et al., 2009, Nanda et al., 2009, Salzer and Kumar, 2009, Starz-Gaiano et al., 2009, Sung et al., 2009, Weasner et al., 2009, Anderson and Kumar, 2008, Baumgardt et al., 2008, Braid and Verheyen, 2008, Brás-Pereira and Casares, 2008, Chen et al., 2008, Duong et al., 2008, Hanai et al., 2008, Hayashi et al., 2008, Kim et al., 2008, Leatherman and DiNardo, 2008, McKay et al., 2008, McNabb and Truman, 2008, Melicharek et al., 2008, Morillo et al., 2008, Salzer and Kumar, 2008, Tanaka-Matakatsu and Du, 2008, Ulvklo et al., 2008, Umezaki and Tomioka, 2008, Yasugi et al., 2008, Aerts et al., 2007, Baumgardt et al., 2007, Baumgardt et al., 2007, Christensen et al., 2007.10.29, Dietzl et al., 2007, Fic et al., 2007, Haerty et al., 2007, Hempel and Oliver, 2007, Herrero et al., 2007, Jemc and Rebay, 2007, Jones, 2007, Kumar and Datta, 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Mecklenburg, 2007, Meignin et al., 2007, Nilsson et al., 2007, Polesello and Tapon, 2007, Sprecher et al., 2007, Tanentzapf et al., 2007, Wang et al., 2007, Weasner et al., 2007, Zeitlinger et al., 2007, Anderson et al., 2006, Borghese et al., 2006, Clark et al., 2006, Friedrich, 2006, Le Bras and Van Doren, 2006, Mahoney et al., 2006, Ostrin et al., 2006, Philippakis et al., 2006, Wijnen et al., 2006, Zhang et al., 2006, Choi et al., 2005, Chotard et al., 2005, Katsuyama et al., 2005, Roederer et al., 2005, Sarfare et al., 2005, Wawersik et al., 2005, Zimmerman et al., 2004, Fabrizio et al., 2003, Silver et al., 2003, Bonini et al., 1998)
Name Synonyms
Eyes-Absent
Eyes-absent
delayed gonad formation 1
eyeless 2
eyes-absent
Secondary FlyBase IDs
  • FBgn0000623
  • FBgn0004612
  • FBgn0063692
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (598)