FlyBase Gene Report: Dmel\cm

ADAPTOR PROTEIN COMPLEX 3 -: Adaptor protein (AP) complexes select cargo for inclusion into coated vesicles in the late secretory and endocytic pathways. AP complexes are heterotetramers. AP-3 is associated with endosomes and, to a less extent, the trans-Golgi network and appears to function independently of clathrin. Drosophila AP-3 genes were first linked to defects in the biogenesis of visual pigment granules. (Adapted from FBrf0129983 and PMID:15066634).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cm: carmine

Eye color translucent dark ruby. With st, eye color deep orange; with brown, slightly lighter than bw alone. Larval Malpighian tubes very pale yellow. RK1.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\cm or the JBrowse view of Dmel\cm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cm-RA

FBtr0071033

NM_176700

1469

415

cm-RB

FBtr0332315

NM_001272373

1774

415

Additional Transcript Data and Comments

Reported size (kB)

1.455 (sequence analysis)

(Mullins et al., 1999)

1.476 (sequence analysis)

(Zhang and Broadie, 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

cm-PA

FBpp0070992

46.8

415

8.19

NP_788873

AAF46231

cm-PB

FBpp0304594

46.8

415

8.19

NP_001259302

AGB95147

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

415 aa isoforms: cm-PA, cm-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

415 (aa)

(Mullins et al., 1999, Zhang and Broadie, 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O76928

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

cm_1

Linkouts

Gene Ontology (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cargo adaptor activity

inferred from sequence or structural similarity with FLYBASE:AP-1μ; FB:FBgn0024833

(FlyBase Curators, 2008--)

inferred from sequence or structural similarity with FLYBASE:AP-2μ; FB:FBgn0263351

(FlyBase Curators, 2008--)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

determination of adult lifespan