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Gene Dmel\cm

General Information
Symbol	Dmel\cm	Species	D. melanogaster
Name	carmine	Annotation symbol	CG3035
Feature type	protein_coding_gene	FlyBase ID	FBgn0000330
Gene Model Status	Current	Stock availability	29 publicly available
Also Known As	μ3, AP-3, AP3μ3, apm3
Genomic Location
Chromosome (arm)	X	Recombination map	1-18.9
Cytogenetic map	6E4-6E4	Sequence location	X:6,903,039..6,905,178 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene carmine is referred to in FlyBase by the symbol Dmel\cm (CG3035, FBgn0000330). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: Notch receptor processing; endocytosis; determination of adult lifespan; ommochrome biosynthetic process; neurogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; mesothoracic tergum; rhabdomere; eye; wing; secondary pigment cell pigment granule; tertiary pigment cell pigment granule; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Clathrin adaptor, mu subunit; Clathrin adaptor, mu subunit, C-terminal; Clathrin adaptor, mu subunit, conserved site; Longin-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1636858_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of cm: 13 out of 14 probes fall into this exonic region. Gene sequence location is X:6903039..6905178.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	cm: carmine Eye color translucent dark ruby. With st, eye color deep orange; with brown, slightly lighter than bw alone. Larval Malpighian tubes very pale yellow. RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms molecular_function exocytosis
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6E4-6E4   Limits computationally determined from genome sequence between P{EP}inx7EP1641 and P{EP}CG9650EP1340&P{EP}CG9650EP1617
Experimentally Determined Cytological Location
Cytogenetic map Notes References 6E-6E     (Zhang, 1998.7.17) 6E1-6E4   (determined by in situ hybridisation)   (Zhang and Broadie, 1999) 6E-6E   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location	1-18.9 (Nicklas and Cline, 1983, ) 1-18.8 (Neel, 1942)
Left of (cM)	ct sn (Johnson and Judd, 1979)
Right of (cM)	stout (Nicklas and Cline, 1983)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 This gene model; overlaps 5'UTR of downstream gene CG2977 (transcript CG2977-RB)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cm-RA FBtr0071033  NM_176700   1469   415 cm-RB FBtr0332315  NM_001272373   1774   415
Additional Transcript Data & Comments
Reported size (kB)	1.476 (sequence analysis) (Zhang and Broadie, 1999) 1.455 (sequence analysis) (Mullins et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cm-PA   FBpp0070992   46.8   415   8.19     NP_788873   AAF46231 cm-PB   FBpp0304594   46.8   415   8.19     NP_001259302   AGB95147
Additional Polypeptide Data & Comments
Reported size (kDa)	415 (aa) (Mullins et al., 1999, Zhang and Broadie, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor, mu subunit, conserved site (IPR018240) Clathrin adaptor, mu subunit (IPR001392) Clathrin adaptor, mu subunit, C-terminal (IPR008968) Longin-like domain (IPR011012)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390968   AE014298 AAF46231   AF110233 AAF14249   AE014298 AGB95147   AI403995   AJ009657 CAA08768   AW942086   AY069388 AAL39533   BF486873   BI214681   CA807360   CO317021   CO336059   CZ490188   CZ490189   EC089481   EC240360   EC265039   EV575868   EV578423   GH833098
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76928
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mullins et al., 1999)
Additional Descriptive Data
	cm transcripts are detected at all stages of development tested. (Mullins et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult hindgut, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    111.7 Larval Midgut    75.5 Larval Hindgut    110.5 Larval Malpighian Tubules    83.9 Larval Fat Body    117.9 Larval Salivary Gland    147 Larval Trachea    141.1 Larval Carcass    95.575 Adult Head    108.9 Adult Eye    118.975 Adult Brain    142 Adult Thoracic-Abdominal Ganglion    152.9 Adult Crop    91.3 Adult Midgut    58.2 Adult Hindgut    108.9 Adult Malpighian Tubules    63.2 Adult Fat Body    79.3 Adult Salivary Gland    189.7 Adult Heart    71.85 Adult VirginFemale Spermatheca    60.8 Adult InseminatedFemale Spermatheca    69.5 Adult Ovary    135.4 Adult Testis    40.3 Adult Male Accessory Gland    140.4 Adult Carcass    77.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    108.9   NA  Eye    118.975   NA  Brain    142   111.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    152.9   NA  Crop    91.3   75.5  Midgut    58.2   110.5  Hindgut    108.9   83.9  Malpighian Tubules    63.2   117.9  Fat Body    79.3   147  Salivary Gland    189.7   NA  Heart    71.85   141.1  Trachea    NA   NA  VirginFemale Spermatheca    60.8   NA  InseminatedFemale Spermatheca    69.5   NA  Ovary    135.4   NA  Testis    40.3   NA  Male Accessory Gland    140.4   95.575  Carcass    77.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    6 central nervous system, pupae P8    4 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    4 head, mated 4-day male    5 head, mated 20-day male    5 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    3 digestive system, 4-day adult    2 digestive system, 20-day adult    3 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    6 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (31) embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr  (28) embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr  28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    31 embryo 04-06hr    17 embryo 06-08hr    21 embryo 08-10hr    25 embryo 10-12hr    28 embryo 12-14hr    20 embryo 14-16hr    21 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    11 larva L2    13 larva L3 12hr old    11 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    16 white prepupae 12hr    15 white prepupae 24hr    17 pupae 2d postWPP    12 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    9 adult male 30day    9 adult female 01day    16 adult female 05day    18 adult female 30day    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    16 embryonic 1182-4H    8 embryonic GM2    8 embryonic Kc167    8 embryonic S1    13 embryonic S3    12 leg disc CME L1    12 wing disc CME-W2    9 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    13 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    10 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    14 ovary fGS/OSS    10 ovary OSC    3 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    10 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3035-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal cmGD10049 lethal, with Scer\GAL4Act5C.PU cmGD10049 lethal | larval stage | recessive cm5 viable cmf05774 viable, with Scer\GAL4pnr-MD237 cmGD10049 Sterility Allele fertile cmf05774 Other Phenotypes Allele eye color defective cm1 cmunspecified eye color defective | recessive cm1 cm2 neuroanatomy defective | larval stage cmGD10049 short lived | male cm1 visible, with Scer\GAL4pnr-MD237 cmGD10049 visible | recessive cm1 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH cmGD10049 ganglion mother cell | larval stage cmGD10049 Malpighian tubule cm1 mesothoracic tergum, with Scer\GAL4pnr-MD237 cmGD10049 pigment cell cm1 cm2 cmunspecified rhabdomere cm1 secondary pigment cell pigment granule cm1 tertiary pigment cell pigment granule cm1 wing, with Scer\GAL4Bx-MS1096 cmGD10049
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of cm Class Mutagen Stocks Known lesion cm1 spontaneous 24 Yes cmf05774 piggyBac transposase 2 -- cmf07380 piggyBac transposase 1 -- cm2 bis(2-chloroethyl) sulfide 0 -- cm3 X ray 0 -- cm41c27 spontaneous 0 -- cm4 spontaneous 0 Yes cm5 ethyl methanesulfonate 0 -- cmMR17 0 -- cmMR19 0 -- cmMR8 0 -- cmunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cm Class Mutagen Stocks Known lesion cmGD10049 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cmJF02594 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cmKK107773 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cmNIG.3035R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)cm2a (Simpson and Wieschaus, 1990) Df(1)cm7c (Simpson and Wieschaus, 1990) Df(1)cm10a (Simpson and Wieschaus, 1990) Df(1)cm13a (Simpson and Wieschaus, 1990) Df(1)cm14a (Simpson and Wieschaus, 1990) Df(1)cmD15 (Simpson and Wieschaus, 1990) Df(1)cm-R8 (Valencia, 1966) Df(1)ct268-37   Df(1)ct-J6 (Nicklas and Cline, 1983) Df(1)GCF (Nicklas and Cline, 1983) Df(1)HA32 (Craymer and Roy, 1980, Nicklas and Cline, 1983, Simpson and Wieschaus, 1990, Watanabe and Kankel, 1990) Df(1)LIMDF (Simpson and Wieschaus, 1990, Rose and Wieschaus, 1992) Df(1)LIMWO (Simpson and Wieschaus, 1990) Df(1)Sxl-bt (Nicklas and Cline, 1983, Watanabe and Kankel, 1990) Df(1)Sxl-nl (Simpson and Wieschaus, 1990)
Duplicated in	Dp(1;3)ct11a   Dp(1;3)ct268-37 (Demerec, 1940) Dp(1;3)DC166 (Popodi et al., 2010-, Venken et al., 2010) Dp(1;3)DC489 (Popodi et al., 2010-) Dp(1;3)sn13a1 (Lefevre and Johnson, 1973, Lefevre, 1981, Cline, 1983) Dp(1;Y)ct+y+ (Johnson and Judd, 1979, Nicklas and Cline, 1983) Tp(1;2)sn+72d (Lefevre, 1981)
Not duplicated in	Dp(1;2)ct7c1   Dp(1;2)sn+72d (Nicklas and Cline, 1983) Dp(1;f)q2
Not disrupted in	Df(1)6F1-2 (Simpson and Wieschaus, 1990, Rose and Wieschaus, 1992) Df(1)ct78 (Simpson and Wieschaus, 1990, Rose and Wieschaus, 1992) Df(1)ct-J4 (Nicklas and Cline, 1983) Df(1)L-1-2 (Simpson and Wieschaus, 1990, Rose and Wieschaus, 1992) Df(1)L-1-18 (Simpson and Wieschaus, 1990) Df(1)LV16 (Simpson and Wieschaus, 1990, Rose and Wieschaus, 1992) Df(1)ogre18-183 (Watanabe and Kankel, 1990) Df(1)RF19 (Nicklas and Cline, 1983) Df(1)Sp8A (Schalet, 1986) Df(1)Sxl-ra (Nicklas and Cline, 1983, Simpson and Wieschaus, 1990) Dp(1;f)A12 (Mackensen, 1935) In(1)F10h1 (Simpson and Wieschaus, 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10049} NA P{KK107773} NA P{NIG.3035R} NA P{TRiP.JF02594} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}cm1 NA ?{}cm4 NA PBac{WH}cmf05774 NA PBac{WH}cmf07380 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2013-03-21)
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Simonsen et al., 2007) endocytosis inferred from mutant phenotype (Wilkin et al., 2008) exocytosis inferred from mutant phenotype (Asensio et al., 2010) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) Notch receptor processing inferred from mutant phenotype (Wilkin et al., 2008) ommochrome biosynthetic process inferred from mutant phenotype (Tearle, 1991)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
intracellular protein transport inferred from electronic annotation with InterPro:IPR001392, InterPro:IPR008968, InterPro:IPR018240 (FlyBase Curators et al., 2004-) intracellular transport traceable author statement (Narayanan and Ramaswami, 2001) lysosome organization inferred from sequence or structural similarity (Mullins and Bonifacino, 2001) neurotransmitter secretion non-traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle coating traceable author statement (Stimson and Ramaswami, 1999) vesicle coating traceable author statement (Stimson and Ramaswami, 1999)
Cellular Component
CV term Evidence References
AP-3 adaptor complex inferred from sequence or structural similarity with human AP3M1 (Boehm and Bonifacino, 2001) clathrin adaptor complex inferred from sequence or structural similarity with UniProtKB:P53678 (FlyBase, 1992-) non-traceable author statement (Zhang, 1998.7.17) coated vesicle traceable author statement (Stimson and Ramaswami, 1999) synaptic vesicle traceable author statement (Stimson and Ramaswami, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cm - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - CG14786 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) cm - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cm allele Gene References cmunspecified w (Lloyd et al., 2002) unspecified bchs (Simonsen et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58125 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000330 DroID - A comprehensive database of gene and protein interactions. • FBgn0000330 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31647 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76928
Orthologs
OrthoDB Orthologs (43) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG637S0P Dipteran inclusive ortholog search EOG6NZV2S Insect inclusive ortholog search EOG6RXWVP Arthropod inclusive ortholog search EOG6KD52K Metazoa inclusive ortholog search EOG60W7H3
Orthologs in Drosophila Species (EOG637S0P)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cm     Drosophila simulans   Dsim\GD16169 Y   Drosophila sechellia   Dsec\GM17484 Y   Drosophila erecta   Dere\GG17643 Y   Drosophila yakuba   Dyak\GE17549 Y   Drosophila ananassae   Dana\GF20328 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15778 Y   Drosophila persimilis   Dper\GL26809 Y   Drosophila willistoni   Dwil\GK25293 Y   Drosophila virilis   Dvir\GJ15801 Y   Drosophila mojavensis   Dmoj\GI21579 Y   Drosophila grimshawi   Dgri\GH24272 Y
Orthologs in non-Drosophila Dipterans (EOG6NZV2S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011429   Anopheles gambiae Malaria mosquito  Agam\AGAP001484   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009776
Orthologs in non-Dipteran Insects (EOG6RXWVP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552520   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG026905   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15955   Atta cephalotes Leafcutter ant  Acep\ACEP14654   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19574   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20995   Linepithema humile Argentine ant  Lhum\LH12237   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14332   Solenopsis invicta Red fire ant  Sinv\SINV18169   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005615   Bombyx mori Silkmoth  Bmor\BGIBMGA007825   Pediculus humanus Human body louse  Phum\PHUM291240   Tribolium castaneum Red flour beetle  Tcas\TC011059
Orthologs in non-Insect Arthropods (EOG6KD52K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\PGKB
Orthologs in non-Arthropod Metazoa (EOG60W7H3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\apm-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019622gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006765gn   Danio rerio Zebrafish  Drer\ap3m2   Danio rerio Zebrafish  Drer\ap3m1   Xenopus tropicalis Western clawed frog  Xtro\ap3m2   Gallus gallus Domestic chicken  Ggal\AP3M1   Gallus gallus Domestic chicken  Ggal\AP3M2   Mus musculus House mouse  Mmus\Ap3m1   Mus musculus House mouse  Mmus\Ap3m2   Rattus norvegicus Norway rat  Rnor\Ap3m2   Rattus norvegicus Norway rat  Rnor\Ap3m1   Homo sapiens Human  Hsap\AP3M1   Homo sapiens Human  Hsap\AP3M2
Human Orthologs (2)
Gene OMIM HGNC Hsap\AP3M1     Hsap\AP3M2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16169 Drosophila sechellia Dsec\GM17484 Drosophila erecta Dere\GG17643 Drosophila yakuba Dyak\GE17549 Drosophila ananassae Dana\GF20328 Drosophila pseudoobscura pseudoobscura Dpse\GA15778 Drosophila persimilis Dper\GL26809 Drosophila willistoni Dwil\GK25293 Drosophila virilis Dvir\GJ15801 Drosophila mojavensis Dmoj\GI21579 Drosophila grimshawi Dgri\GH24272
Stocks & Reagents
Stocks Listed in FlyBase ( 29 )
Bloomington	21 cm1 22 cm1 ct6 4679 cm1 l(1)7Dd4/FM7a 18905 w1118 PBac{WH}cmf05774 3169 cm1 ct6 mysts1 27282 y1 v1; P{TRiP.JF02594}attP2
Harvard	- PBac{WH}cmf05774 - PBac{WH}cmf07380
Kyoto	105681 cm1 106890 cm1 ct6 mysts1 106261 cm1 m74f sd1 oss
VDRC	v21139 w1118; P{GD10049}v21139
	More stocks available...
Genomic Clones ( 1 )
	BACR17C09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD09732
Other clones	DPiM_LD09732
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21424 GH23560 RE20674
Other clones	162586 556947 CK01.16D.E9 Dmel_dig_005069_0652_2572 Dmel_dig_008419_0665_0831 EK266736 EN11736 ESG017c.E21.3_E01 RP003419359
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31647
Antibody Information
Other Information
Discoverer
	Mohr, 27th April 1927.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cm AP-3 (FlyBase, 1996-) Source for merge of: cm Mu3 (Mullins et al., 1999)
Additional comments	Source for merge of cm AP-3 was sequence comparison (date:991227). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) hobo dysgenesis causes instability at the cm locus, in progeny derived from the unstable chromosome U-7 line. Once cm mutations are produced they are genetically stable and do not revert. Cytological analysis suggests that the mutations involve minute structural aberrations, and molecular analysis revealed that many result from the deletion of DNA between two hobos. (Sheen et al., 1993) Lesions in cm reduce or eliminate pigmentation in the eyes and ocelli and block pigmentation of the fat body and tubules: cm is required for normal pigmentation of all four tissues. (Tearle, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176700 NM_001272373 RefSeq (Proteins) • NP_788873 NP_001259302 DDBJ / EMBL / GenBank • AA390968 AAF14249 AAF46231 AAL39533 AF110233 AGB95147 AJ009657 AW942086 AY069388 CAA08768 CZ490188 CZ490189 Entrez Gene - A searchable database of RefSeq genes. • 31647 UniProtKB/TrEMBL • O76928
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Clathrin adaptor, mu subunit, conserved site (IPR018240) Clathrin adaptor, mu subunit (IPR001392) Clathrin adaptor, mu subunit, C-terminal (IPR008968) Longin-like domain (IPR011012)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58125 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0000330 DroID - A comprehensive database of gene and protein interactions. • FBgn0000330 DRSC - Results from RNAi screens. • FBgn0000330 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000330 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3035-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000330 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31647 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31647 modMine - Data generated by the modENCODE project. • FBgn0000330 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76928
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	AP-3 (Mullins, 1998.12.1, Lewin and Mellman, 1998, ) ap-3 (Asensio et al., 2010) AP-3μ (Bonifacino et al., 2012.12.21) AP3μ3 (Burgess et al., 2011, Kametaka et al., 2012) apm3 (Neumann et al., 2010, Neumann et al., 2010) cg3035 (Boehm and Bonifacino, 2002) CG3035 (Boehm, 2001, Verstreken and Bellen, 2000.9.4, Lebo et al., 2009, Keleman et al., 2009.8.5) CG32731   cm (Falcon-Perez et al., 2007, Dietzl et al., 2007, Wilkin et al., 2008, Chinchore et al., 2009, Anaka et al., 2008, Perkins et al., 2009.8.10, Cheli et al., 2010, Popodi et al., 2010-, Burgess et al., 2011, Neumüller et al., 2011, Müller et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Venken et al., 2010) Dμ3 (Jullien-Flores et al., 2000) l(1)VEM119   mu3 (Zhang, 1998.7.17) Mu3   μ3 (Boehm and Bonifacino, 2001, Mullins et al., 1999, Mullins et al., 1999, Zhang and Broadie, 1999, Kametaka et al., 2012)
Name Synonym	Adaptor Protein complex 3, μ subunit (Bonifacino et al., 2012.12.21) carmine (Falcon-Perez et al., 2007, Simonsen et al., 2007, Wilkin et al., 2008, Muraro and Moffat, 2006, Lebo et al., 2009, Chinchore et al., 2009, Anaka et al., 2008, Kametaka et al., 2010, Burgess et al., 2011, Kinser and Dolph, 2012)
Secondary FlyBase IDs
	FBgn0020512 FBgn0024949
References ( 89 )
Generate a list of	All references relating to this gene ( 89 )
List References by type	Research paper  ( 50 ) Supplementary material  ( 8 ) Review  ( 8 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Book  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589] Kinser and Dolph, 2012, Neurobiol. Disease 46(3): 655--662 Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila. [FBrf0218298] Burgess et al., 2011, Mol. Biol. Cell 22(12): 2094--2105 AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. [FBrf0213890] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...