Mutation in sequenced strain: deletion (removes 3' end); see allele report cn.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cn using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cn in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: cn CG1555
Lesions in cn block pigmentation in the eye, ocelli, tubule and fat body.
Heterozygotes in all pairwise combinations of 13 EMS-induced alleles exhibit mutant phenotype. Ethyl methanesulfonate-induced mutants can be recovered as mosaics in homozygous red background.
cn mutants are defective in the uptake of kynurenine by eye discs and Malpighian tubules, where it is normally converted to 3-hydroxykynurenine.
Kynurenine 3-hydroxylase activity proportional to the number of doses of cn+; cn+ therefore concluded to be the structural gene for the enzyme. Enzyme activity is developmentally regulated with a peak of activity in early third instar and a five-fold higher peak in the second half of pupal development.
Larval Malpighian tubes are pale yellow.
Nonautonomous in development of pigment of transplanted eye discs.
Clausen, 8th Sep. 1920.