A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Gene Dmel\cn

General Information
SymbolDmel\cnSpeciesD. melanogaster
NamecinnabarAnnotation symbolCG1555
Feature typeprotein_coding_geneFlyBase IDFBgn0000337
Created / Updated2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)2RRecombination map2-57.5
Cytogenetic map 43E16-43E16 Sequence location2R:3,670,302..3,672,711 [-]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
The gene cinnabar is referred to in FlyBase by the symbol cn (CG1555, FBgn0000337). It has the cytological map location 43E16. Its sequence location is 2R:3670302..3672711. Its molecular function is described as: kynurenine 3-monooxygenase activity; electron carrier activity; FAD binding. It is involved in the biological processes: ommochrome biosynthetic process; eye pigment biosynthetic process; compound eye pigmentation; tryptophan catabolic process; tRNA processing. 223 alleles are reported. The phenotypes of these alleles are annotated with: ocellus; pigment cell; ocellus pigment granule; Malpighian tubule. It has one annotated transcript and one annotated polypeptide.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
cn: cinnabar
Eye color bright red, like v or st. Ocelli colorless. Eye color darkens with age, but ocelli remain colorless. Larval Malpighian tubes pale yellow (Beadle, 1937, Genetics 22: 587-611). cn defective in ommochrome synthesis; blocks conversion of kynurenine to 3-hydroxykynurenine, which has been identified as the cn+ hormone (Butenandt, Weidel, and Schlossberger, 1949, Z. Naturforsch. 4b: 242-44). cn homozygotes devoid of kynurenine 3-hydroxylase activity (Ghosh and Forrest, 1967, Genetics 55: 423-31). Enzyme activity proportional to the number of doses of cn+; cn+ therefore concluded to be the structural gene for kynurenine 3-hydroxylase (EC 1.14.13.9) (Sullivan, Kitos, and Sullivan, 1973, Genetics 75: 651-61). Also cn defective in the uptake of kynurenine by eye discs and Malpighian tubules, where it is normally converted to 3-hydroxykynurenine (Sullivan, Grillo, Kitos, 1974, J. Exp. Zool. 188: 225-34). Nonautonomous in development of pigment of transplanted eye disks (Beadle and Ephrussi, 1936, Genetics 21: 230); however, ethyl methanesulfonate-induced mutants recovered as mosaics in homozygous red background (Paton and Sullivan, 1978, Biochem. Genet. 16: 855-65); furthermore, even though st has no detectable 3-hydroxykynurenine, it is able to rescue cn in transplants (Phillips, Simmons, and Bowman, 1970, Biochem. Genet. 4: 481-87). Enzyme activity developmentally regulated with a peak of activity in early third instar and a five-fold higher peak in the second half of pupal development (Sullivan et al.). Heterozygotes in all pairwise combinations of 13 ethyl methanesulfonate-induced alleles exhibit mutant phenotype (Paton and Sullivan, 1978). RK1.
cnrbr
An unstable amorphic allele that reverts with frequency of 3 x 10-3 (Valade del Rio, 1974, DIS 51: 22); also induces reversions of cn1 and cn2 alleles on homologous chromosome in heterozygotes; some of the revertants themselves mutate back to cnrbr (Valade del Rio, 1982, Experientia 38: 790-92).
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
43E16-43E16  
Limits computationally determined from genome sequence between P{PZ}l(2)0849208492 and P{EP}CanB2EP774  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
43E6-43E8
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: CanB2- cn+
Overall orientation not stated: cn- CanB2+ Gapdh1- mus205+
hide Gene Model & Products
Please see the GBrowse view of Dmel\cn for information on other features
detailed view FBtr0088932 FBtr0088931 FBtr0088930 FBpp0088005 FBpp0088004 FBti0071048 FBti0026054 FBti0072496 FBti0039179 FBti0049573 FBti0066882 FBti0046607 FBti0045373 FBti0065210 FBti0065840 FBti0065564 FBti0065982 FBti0067246 FBti0018392 FBti0056477 FBti0035531 FBti0037165 FBti0066429 FBti0007694 FBti0033692
Comments on Gene Model
Known mutation in sequenced strain
EST data suggest additional 5' exon(s)
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0088931
  1929
  524
Additional Transcript Data & Comments
Reported size (kB)
2.2, 1.8 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
cn-PA  
FBpp0088005  
59.4  
524  
8.69  
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     larval stage-pupal stage
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
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        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        FlyExpress - Embryonic expression images (BDGP data)
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        Other Phenotypes
        Allele
        Sterility
        Allele
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 221 )
        For All Classical Alleles Show

        Allele of cnClassMutagenStocksKnown lesion
        cn+c
          0 --
          cn+e
            0 --
            cn10P0 --
            cn11P0 --
            cn12Phypomorph0 --
            cn13P0 --
            cn14P0 --
            cn15P0 --
            cn16P0 --
            cn17P0 --
            cn18P0 --
            cn19P0 --
            cn11587 Yes
            cn20P0 --
            cn21P0 --
            cn22P0 --
            cn23P0 --
            cn24P0 --
            cn25P0 --
            cn26P0 --
            cn27P0 --
            cn28P0 --
            cn29P0 --
            cn2hypomorph284 Yes
            cn2Pamorph6 --
            cn30P0 --
            cn31Pamorph0 --
            cn35khypomorph3 Yes
            cn36c
              0 --
              cn38jhypomorph
                0 --
                cn3amorph
                  2 Yes
                  cn45j0 --
                  cn4amorph
                    3 Yes
                    cn4P0 --
                    cn57e0 --
                    cn5P0 --
                    cn67d0 --
                    cn6P0 --
                    cn72a20 --
                    cn74b10 --
                    cn74b20 --
                    cn74b30 --
                    cn74b40 --
                    cn74c20 --
                    cn74c50 --
                    cn74c70 --
                    cn74c80 --
                    cn74c90 --
                    cn74d10 --
                    cn74d40 --
                    cn74d50 --
                    cn74d70 --
                    cn74d80 --
                    cn75a20 --
                    cn76b0 --
                    cn76e20 --
                    cn76i0 --
                    cn76k10 --
                    cn76k20 --
                    cn77a100 --
                    cn77a20 --
                    cn77a30 --
                    cn77a40 --
                    cn77a90 --
                    cn77c20 --
                    cn78amorph0 --
                    cn78a0 --
                    cn78b10 --
                    cn78f0 --
                    cn78g0 --
                    cn78j20 --
                    cn78k10 --
                    cn78l0 --
                    cn79b100 --
                    cn79b110 --
                    cn79b15