HomeGene Dmel\cnc
| General Information | |||
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| Symbol | Dmel\cnc | Species | D. melanogaster |
| Name | cap-n-collar | Annotation symbol | CG17894 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0000338 |
| Created / Updated | 2003-12-01/2003-12-01 | ||
| Genomic Location | |||
| Chromosome (arm) | 3R | Recombination map | 3-81.2 |
| Cytogenetic map | 94E4-94E7 | Sequence location | 3R:19,011,300..19,047,683 [-] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene cap-n-collar is referred to in FlyBase by the symbol cnc (CG17894, FBgn0000338). It has the cytological map location 94E4-94E7. Its sequence location is 3R:19011300..19047683. Its molecular function is described as: DNA binding; transcription activator activity; RNA polymerase II transcription factor activity; transcription factor activity; protein heterodimerization activity; sequence-specific DNA binding; protein dimerization activity. It is involved in the biological processes: blastoderm segmentation; bicoid mRNA localization; pole plasm oskar mRNA localization; maintenance of oocyte nucleus localization during oocyte axis determination; oocyte dorsal/ventral axis determination; oocyte microtubule cytoskeleton polarization; regulation of bicoid mRNA localization; regulation of pole plasm oskar mRNA localization; regulation of transcription, DNA-dependent. 47 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system; abdominal ventral denticle belt; cephalopharyngeal skeleton; larval abdominal segment; embryonic head; pharyngeal sclerite; embryonic procephalic segment; embryonic segment; gamete; egg; embryonic gnathal segment; abdominal 5 ventral denticle belt; mouthpart; cell part; peripheral nervous system. It has 7 annotated transcripts and 7 annotated polypeptides. | ||
| External Summaries | |||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 94E4-94E7
Limits computationally determined from genome sequence between P{EP}hhEP3521 and P{PZ}cnc03921
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 94E3-94E7 (determined by in situ hybridisation)
94E3-94E7 (determined by in situ hybridisation)
93E4-93E5 94E3--7
94E3-94E4 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | |||
| Location | 3-81.2 | ||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References In direction of increasing cytology: hh- unk- cnc+ Gene Order (overall orientation not stated) References Overall orientation not stated: cnc+ fzo+ cnc+ | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\cnc
for information on other features
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| Comments on Gene Model | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | 2.722 (longest cDNA) 6.6, 5.4, 3.3 (northern blot) | ||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | 533 (aa) 1296, 805, 533 (aa) | ||
| Comments | cnc protein shows the strongest resemblance to the jun subclass of bZIP proteins in the basic binding domain but is very divergent from this class in the leucine-repeat region. | ||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Basic-leucine zipper (bZIP) transcription factor (IPR004827)
Basic leucine zipper (IPR011700)
Kelch related (IPR013089)
TRANSFAC
- Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles
•
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
embryonic stage | 0-2hr
embryonic stage | 0-2hr
embryonic stage | 0-2hr
embryonic stage | stage >=14
embryonic stage
embryonic labral segment
embryonic stage | blastoderm
embryonic stage | early-mid
labral segment
embryonic stage | 12-24hr
embryonic stage
intercalary segment
embryonic stage
embryonic mandibular segment
embryonic stage
mandibular segment
embryonic stage
embryonic stage | >2hr
embryonic stage | stage >14
embryonic stage | blastoderm | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
embryonic stage | stage >14
embryonic stage | stage >=6
embryonic labral segment
embryonic stage | stage >=6
embryonic mandibular segment
embryonic stage | stage >=6
embryonic labral segment
embryonic stage | stage >=6
embryonic mandibular segment
embryonic stage | early | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | nucleus | ||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Stage(s)
1-3
Stage(s)
4-6
Stage(s)
7-8
Stage(s)
9-10