• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\cni

General Information
Symbol	Dmel\cni	Species	D. melanogaster
Name	cornichon	Annotation symbol	CG5855
Feature type	protein_coding_gene	FlyBase ID	FBgn0000339
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	BG:DS02740.13
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35F1-35F1	Sequence location	2L:16,309,594..16,310,736 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cornichon is referred to in FlyBase by the symbol Dmel\cni (CG5855, FBgn0000339). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: blastoderm segmentation; establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; bicoid mRNA localization; intracellular mRNA localization; dorsal/ventral pattern formation; ER to Golgi vesicle-mediated transport; vesicle-mediated transport; anterior/posterior pattern specification; dorsal appendage formation; pole plasm oskar mRNA localization. 12 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; egg; external compound sense organ; female germline cyst; adult segment; sensillum; adult mesothoracic segment; primordium; cell part. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cornichon. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, adult salivary gland, adult female reproductive system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1633961_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of cni. Gene sequence location is 2L:16309594..16310736.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA03512 BKN29331
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F1-35F1   Limits computationally determined from genome sequence between P{lacW}heixk11403&P{lacW}heixk12401 and P{EP}fzyEP1028&P{lacW}mRpL4k14608
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35F6-35F12     (Dawson et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cni for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cni-RA FBtr0080848  NM_165151   823   144 cni-RB FBtr0080849  NM_057720   836   144
Additional Transcript Data & Comments
Reported size (kB)	0.9 (northern blot) (Roth et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cni-PA   FBpp0080405   16.9   144   6.77     NP_723959   AAF53521 cni-PB   FBpp0080406   16.9   144   6.77     NP_477068   AAF53522
Additional Polypeptide Data & Comments
Reported size (kDa)	144 (aa); 17 (kD predicted) (Roth et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cornichon (IPR003377)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53521   AE014134 AAF53522   AC092398   AE003415 AAF45003   AI108019   AI516860   BG636111   BH610007   BI632700   BI638772   BI641396   BT011529   CO192095   CO192173   CO193619   CO294744   CO332465   CO338728   EC224595   GH749018   GH750413   GH754606   GH781089   GH782161   GH783248   GH791827   GH794759   GH798970   GH802319   GH806919   GH813361   GH813598   GH813677   GH814814   GH817514   GH820361   GH821529   GH824359   GH824565   GH827231   GH829791   GH843085   GH855588   GH859090   GH868346   GH871889   GH873271   GH874787   GH879885   GH880316   GH884509   GH893886   GH902919   GH905596   GH906837   GH912831   GH914476   GH920567   GH921244   GH921924   GH922401   GH924198   GH931910   GH933901   U28069 AAA86527
UniProtKB/Swiss-Prot	P49858
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   germarium   (Roth et al., 1995) adult stage & oogenesis stage S10   nurse cell   (Roth et al., 1995) oogenesis stage S1 -- S7     (Roth et al., 1995)
Additional Descriptive Data
	cni transcripts are expressed in the germarium, in early egg chambers, and in the nurse cells of a stage S10 egg chamber. cni expression is strongly down-regulated in egg chambers of stages S8 and S9. (Roth et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000339    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000339 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000339 expression level Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3962) embryo 02-04hr  (5527) embryo 04-06hr  (5964) embryo 06-08hr  (4580) embryo 08-10hr  (6195) embryo 10-12hr  (7596) embryo 12-14hr  (5153) embryo 14-16hr  (2409) embryo 16-18hr  (2936) embryo 18-20hr  (2092) embryo 20-22hr  (2829) embryo 22-24hr  (3635) larva L1  (2106) larva L2  (3371) larva L3 12hr old  (3456) larva L3 puffstage 1-2  (3536) larva L3 puffstage 3-6  (4086) larva L3 puffstage 7-9  (8231) white prepupae new  (7144) white prepupae 12hr  (3670) white prepupae 24hr  (2751) pupae 2d postWPP  (2653) pupae 3d postWPP  (2100) pupae 4d postWPP  (1955) adult male 01day  (2484) adult male 05day  (2688) adult male 30day  (2386) adult female 01day  (2122) adult female 05day  (3498) adult female 30day  (3702) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3962) embryo 02-04hr  (5527) embryo 04-06hr  (5964) embryo 06-08hr  (4580) embryo 08-10hr  (6195) embryo 10-12hr  (7596) embryo 12-14hr  (5153) embryo 14-16hr  (2409) embryo 16-18hr  (2936) embryo 18-20hr  (2092) embryo 20-22hr  (2829) embryo 22-24hr  (3635) larva L1  (2106) larva L2  (3371) larva L3 12hr old  (3456) larva L3 puffstage 1-2  (3536) larva L3 puffstage 3-6  (4086) larva L3 puffstage 7-9  (8231) white prepupae new  (7144) white prepupae 12hr  (3670) white prepupae 24hr  (2751) pupae 2d postWPP  (2653) pupae 3d postWPP  (2100) pupae 4d postWPP  (1955) adult male 01day  (2484) adult male 05day  (2688) adult male 30day  (2386) adult female 01day  (2122) adult female 05day  (3498) adult female 30day  (3702) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000339 expression level Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3962) embryo 02-04hr  (5527) embryo 04-06hr  (5964) embryo 06-08hr  (4580) embryo 08-10hr  (6195) embryo 10-12hr  (7596) embryo 12-14hr  (5153) embryo 14-16hr  (2409) embryo 16-18hr  (2936) embryo 18-20hr  (2092) embryo 20-22hr  (2829) embryo 22-24hr  (3635) larva L1  (2106) larva L2  (3371) larva L3 12hr old  (3456) larva L3 puffstage 1-2  (3536) larva L3 puffstage 3-6  (4086) larva L3 puffstage 7-9  (8231) white prepupae new  (7144) white prepupae 12hr  (3670) white prepupae 24hr  (2751) pupae 2d postWPP  (2653) pupae 3d postWPP  (2100) pupae 4d postWPP  (1955) adult male 01day  (2484) adult male 05day  (2688) adult male 30day  (2386) adult female 01day  (2122) adult female 05day  (3498) adult female 30day  (3702) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3962) embryo 02-04hr  (5527) embryo 04-06hr  (5964) embryo 06-08hr  (4580) embryo 08-10hr  (6195) embryo 10-12hr  (7596) embryo 12-14hr  (5153) embryo 14-16hr  2409 embryo 16-18hr  (2936) embryo 18-20hr  2092 embryo 20-22hr  (2829) embryo 22-24hr  (3635) larva L1  2106 larva L2  (3371) larva L3 12hr old  (3456) larva L3 puffstage 1-2  (3536) larva L3 puffstage 3-6  (4086) larva L3 puffstage 7-9  (8231) white prepupae new  (7144) white prepupae 12hr  (3670) white prepupae 24hr  (2751) pupae 2d postWPP  (2653) pupae 3d postWPP  2100 pupae 4d postWPP  1955 adult male 01day  (2484) adult male 05day  (2688) adult male 30day  2386 adult female 01day  2122 adult female 05day  (3498) adult female 30day  (3702) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3962 embryo 02-04hr    5527 embryo 04-06hr    5964 embryo 06-08hr    4580 embryo 08-10hr    6195 embryo 10-12hr    7596 embryo 12-14hr    5153 embryo 14-16hr    2409 embryo 16-18hr    2936 embryo 18-20hr    2092 embryo 20-22hr    2829 embryo 22-24hr    3635 larva L1    2106 larva L2    3371 larva L3 12hr old    3456 larva L3 puffstage 1-2    3536 larva L3 puffstage 3-6    4086 larva L3 puffstage 7-9    8231 white prepupae new    7144 white prepupae 12hr    3670 white prepupae 24hr    2751 pupae 2d postWPP    2653 pupae 3d postWPP    2100 pupae 4d postWPP    1955 adult male 01day    2484 adult male 05day    2688 adult male 30day    2386 adult female 01day    2122 adult female 05day    3498 adult female 30day    3702 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000339    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000339 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, adult salivary gland, adult female reproductive system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000339 expression level Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules    1386.6 Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut    1100.7 Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  507.775 Larval Midgut  (929) Larval Hindgut  (740.8) Larval Malpighian Tubules  (1386.6) Larval Fat Body  (769.9) Larval Salivary Gland  (551.4) Larval Trachea  (648.975) Larval Carcass  (722.575) Adult Head    470.5 Adult Eye  (691.6) Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut  (1100.7) Adult Hindgut  (811.5) Adult Malpighian Tubules  (916.7) Adult Fat Body  (682.6) Adult Salivary Gland    371.2 Adult Heart  (657.2) Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass  (551) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules  (1386.6) Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut  (1100.7) Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules    1386.6 Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut    1100.7 Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000339 expression level Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules    1386.6 Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut    1100.7 Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  507.775 Larval Midgut  (929) Larval Hindgut  740.8 Larval Malpighian Tubules  (1386.6) Larval Fat Body  769.9 Larval Salivary Gland  551.4 Larval Trachea  648.975 Larval Carcass  722.575 Adult Head    470.5 Adult Eye  691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut  (1100.7) Adult Hindgut  811.5 Adult Malpighian Tubules  (916.7) Adult Fat Body  682.6 Adult Salivary Gland    371.2 Adult Heart  657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass  551 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules  1386.6 Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut  1100.7 Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    507.775 Larval Midgut    929 Larval Hindgut    740.8 Larval Malpighian Tubules    1386.6 Larval Fat Body    769.9 Larval Salivary Gland    551.4 Larval Trachea    648.975 Larval Carcass    722.575 Adult Head    470.5 Adult Eye    691.6 Adult Brain    392.5 Adult Thoracic-Abdominal Ganglion    352.9 Adult Crop    401.2 Adult Midgut    1100.7 Adult Hindgut    811.5 Adult Malpighian Tubules    916.7 Adult Fat Body    682.6 Adult Salivary Gland    371.2 Adult Heart    657.2 Adult VirginFemale Spermatheca    237.1 Adult InseminatedFemale Spermatheca    262.9 Adult Ovary    409.7 Adult Testis    391.2 Adult Male Accessory Gland    223.8 Adult Carcass    551 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    470.5   NA  Eye    691.6   NA  Brain    392.5   507.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    352.9   NA  Crop    401.2   929  Midgut    1100.7   740.8  Hindgut    811.5   1386.6  Malpighian Tubules    916.7   769.9  Fat Body    682.6   551.4  Salivary Gland    371.2   NA  Heart    657.2   648.975  Trachea    NA   NA  VirginFemale Spermatheca    237.1   NA  InseminatedFemale Spermatheca    262.9   NA  Ovary    409.7   NA  Testis    391.2   NA  Male Accessory Gland    223.8   722.575  Carcass    551 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000339 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5855-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with cni1), with Df(2L)JS7 cniAA12 lethal (with cniAA12), with Df(2L)JS7 cni1 lethal | embryonic stage | maternal effect | recessive cni1 lethal | maternal effect cniunspecified semi-lethal | dorsal-ventral polarity cni1 viable, with Scer\GAL4pnr-MD237 cniGD4518 Other Phenotypes Allele wild-type cni+t2.4 cnihs.PP Phenotype manifest in Allele chorion cni1 dorsal appendage cni1 cniAA12 cniCF5 dorsal appendage | ectopic cni1 dorsal appendage | maternal effect cni1 egg cni1 cniAA112 cniAA12 cniCF5 egg (with cni1) cniAA12 egg (with cniAA12) cni1 egg chamber cni1 cniAA12 cniCF5 embryonic epidermis cni1 cniAA12 embryonic epidermis | maternal effect cni1 eye cni1 interommatidial bristle | ectopic cni1 mesoderm cniAA12 mesoderm | maternal effect cni1 micropyle | ectopic cni1 ocellar bristle cni1 ommatidium cni1 oocyte (with cni1) cniCF5 oocyte (with cniCF5) cni1 oocyte nucleus cni1 oocyte nucleus (with cni1) cniAA12 oocyte nucleus (with cniAA12) cni1 postvertical bristle cni1 wing vein cni1 wing vein L2 cni1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of cni Class Mutagen Stocks Known lesion cni1 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes cniAA112 1 -- cniKG00189 P-element activity 1 -- cniAA12 ethyl methanesulfonate 0 Yes cniCF5 ethyl methanesulfonate 0 Yes cniunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cni Class Mutagen Stocks Known lesion cniGD4518 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cniKK109331 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cni+t2.4 in vitro construct - genomic fragment 0 Yes cnihs.PP in vitro construct - regulatory fusion 0 Yes cniScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes cniT:Hsap\MYC in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26) Df(2L)H60-3 (Ashburner et al., 1999, Dawson et al., 1995, Roth et al., 1995) Df(2L)II30 (Roote, 1996.8) Df(2L)III18 (Ashburner et al., 1999, Roote, 1995.3.24, Roth et al., 1995, Bergmann et al., 1996, Roote, 1996.8) Df(2L)k08106-rv6 (Roote, 1999.7.7) Df(2L)k08106-rv15 (Roote, 1999.7.7) Df(2L)r10 (Ashburner et al., 1990) Df(2L)RA5 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990, Dawson et al., 1995) Df(2L)TE35D-23 (Ashburner et al., 1990)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A72 (Ashburner et al., 1990) Df(2L)A267 (Ashburner et al., 1990) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)cact-255rv64 (Dawson et al., 1995) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)k08106-rv4 (Roote, 2000.6.13) Df(2L)k08106-rv6 (Roote, 2000.6.13) Df(2L)k08106-rv15 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp29 (Eberl et al., 1998) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-13 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) Df(2L)TE35D-14 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-22 (Ashburner et al., 1990) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Eberl et al., 1998, Ashburner et al., 1990, Dawson et al., 1995) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4518} NA P{KK109331} NA P{UAS-cni.P} NA heat-shock construct P{hs-cni.P} NA characterization construct P{cni+} NA P{cni-myc} NA P{grk-cni.cyto} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}cniKG00189 NA
Gene Ontology: Function, Process & Cellular Component ( 18 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
anterior/posterior pattern specification inferred from mutant phenotype (Roth et al., 1995) bicoid mRNA localization inferred from mutant phenotype (Roth et al., 1995) blastoderm segmentation inferred from mutant phenotype (Roth et al., 1995) dorsal/ventral pattern formation inferred from mutant phenotype (Roth et al., 1995) dorsal appendage formation inferred from mutant phenotype (Peri and Roth, 2000) ER to Golgi vesicle-mediated transport inferred from mutant phenotype (Herpers and Rabouille, 2004) establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification inferred from mutant phenotype (Roth et al., 1995, Herpers and Rabouille, 2004) intracellular mRNA localization inferred from mutant phenotype (Roth et al., 1995) pole plasm oskar mRNA localization inferred from mutant phenotype (Roth et al., 1995) vesicle-mediated transport inferred from mutant phenotype (Bokel et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dorsal/ventral axis specification non-traceable author statement (Swiss-Prot Project Members, 1996.6.1) dorsal/ventral axis specification, ovarian follicular epithelium non-traceable author statement (Swiss-Prot Project Members, 1996.6.1) gurken receptor signaling pathway traceable author statement (Shilo, 2003) intracellular signal transduction inferred from electronic annotation with InterPro:IPR003377 (FlyBase Curators et al., 2004-) oocyte anterior/posterior axis specification non-traceable author statement (Swiss-Prot Project Members, 1996.6.1, Cooperstock and Lipshitz, 1997) oocyte dorsal/ventral axis specification non-traceable author statement (Cooperstock and Lipshitz, 1997)
Cellular Component
CV term Evidence References
integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1996.6.1) membrane inferred from electronic annotation with InterPro:IPR003377 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cni allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0000339 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34967
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15325 Dere\GG24173 Dgri\GH11430 Dmoj\GI14694 Dper\GL14087 Dpse\GA19182 Dsec\GM17911 Dsim\GD21921 Dvir\GJ17163 Dwil\GK23716 Dyak\GE19367
Curated drosophilid orthologs	Dpse\GA19182   Dvir\cni
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007332-PA Aedes aegypti (mosquito) AGAP008974-PA Anopheles gambiae (mosquito) XP_001944808.1 Acyrthosiphon pisum (pea aphid) At3g12180.1 Arabidopsis thaliana (wall cress) 18374 Batrachochytrium dendrobatidis (chytrid fungus) 264252 Branchiostoma floridae (lancelet) ENSBTAP00000025975 Bos taurus (bovine) CAL0004990 Candida albicans (a form of yeast) CN00508 Caenorhabditis brenneri (small nematode) CBP02306 Caenorhabditis briggsae (nematode) CE23961 Caenorhabditis elegans (worm) ENSCAFP00000021971 Canis familiaris (dog) CAGL0I00440g Candida glabrata (haploid yeast) JA15252 Caenorhabditis japonica (nematode) cn03711 Cryptococcus neoformans (yeast-like fungus) CPIJ009353 Culex pipens (mosquito) ENSCPOP00000007627 Cavia porcellus (guinea pig) RP16129 Caenorhabditis remanei (nematode) ENSCSAVP00000000318 Ciona savignyi (sedentary tunicate) 223226 Capitella spl (polychaete worm) DDB0201912 Dictyostelium discoideum (amoeba) DEHA2F02618g Debaryomyces Hansenii (yeast) 189492 Daphnia pulex (daphnia) ENSDARP00000091020 Danio rerio (zebra fish) ENSECAP00000016706 Equus caballus (horse) XP_651069 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015581 Gymnopilus aculeatus (mushroom) ENSGALP00000019918 Gallus gallus (chicken) 185743 Hypsipyla robusta (cedar shoot borer) ENSP00000216416 Homo sapiens (human) KLLA0C05478g Kluyveromyces lactis (yeast) 107610 Lottia gigantea (owl limpet) LmjF32.3840 Leishmania major (virus) 32837 Monocosta brevicollis (choanoflagellate) ENSMODP00000014567 Monodelphis domestica (gray opossum) ENSMMUP00000016176 Macaca mulatta (rhesus monkey) ENSMUSP00000015903 Mus musculus (house mouse) 131022 Nematostella vectensis (starlet anemone) XP_001607460.1 Nasonia vitripennis (wasp) ENSOANP00000002320 Ornithorynchus anatinus (platypus) ENSORLP00000011506 Oryzias latipes (japanese killifish) PHUM003239-PA Pediculus humanus (human body louse) PP02679 Pristionchus pacificus (nematode) ENSPPYP00000006623 Pongo pygmaeus (orangutan) 81111 Phytophthora ramorum (sudden oak death pathogen) 158531 Phytophthora sojae (root rot pathogen) ENSPTRP00000010787 Pan troglodytes (chimpanzee) ENSRNOP00000013331 Rattus norvegicus (norway rat) YGL054C Saccharomyces cerevisiae (budding yeast) Smp_082990 Schistosoma mansoni (trematode parasite) SPAC30C2.05 Schizosaccharomyces pombe (fission yeast) XP_787571.2 Strongylocentrotus purpuratus (purple sea urchin) 32287 Trichoplax adhaerens (metazoa) XP_974854.1 Tribolium castaneum (red flour beetle) Tc00.1047053503823.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510283.110 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022544 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026013 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026714 Xenopus tropicalis (frog) YALI0F12001g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14946 LH23588 ISCW007754 FBgn0236712 FBgn0225678 FBgn0204340 FBgn0193337 FBgn0172818 JGI_V11_189492 FBgn0079179 FBgn0151692 FBgn0137445 FBgn0118910 FBgn0116306 FBgn0092350 CPIJ009353 ACYPI005267 ACYPI000183 GB18925 AGAP008974 AAEL007332 AAEL007327 PB24045 PHUM348080 GLEAN_13453
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	13056 y1 w67c23; P{SUPor-P}cniKG00189 1579 b1 cni1 pr1 cn1 bw1/CyO 34042 b1 cniAA112 pr1 cn1 wxwxt bw1/CyO
Kyoto	106398 b1 cni1 pr1 cn1 bw1/CyO
VDRC	v102019 P{KK109331}VIE-260B v37722 w1118; P{GD4518}v37722 v37723 w1118; P{GD4518}v37723
Genomic Clones ( 1 )
	BACR01N08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE07818
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05943 GH27443 SD13708 SD21145 SD24690 SD26544
Other clones	78368 EC32945 EC33288 EC36503 EK207560 EK303533 EN17504 RP003042822 RP003046265 RP003061978 RP003075717 RP003079024 RP003109350 RP003122064 RP003128727 RP003130467 RP003132451 RP003137474 RP003156109 RP003188850 RP003201737 RP003202141 RP003222286 RP003233639 RP003245469 RP003247311 RP003282908 RP003285336 RP003285737 RP003286747 RP003303328 RP003305928 RP003309992 RP003315857 RP003315993 RP003316170 RP003317144 RP003326285 RP003346389 RP003347288 RP003347973 RP003411664 RP003417515 RP003481071 RP003492316 RP003500707 RP003510317 RP003551693 RP003575806 RP003609244 RP003621137 RP003665125
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000339 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34967
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: cni CG5855 (Zhong, 1999.11)
Source for database merge of	Source for merge of: cni anon-35Fe (Roth et al., 1995)
Additional comments
Other Comments
	Transcript identified during molecular analysis of the fzy genomic region. (Dawson et al., 1995) cni is required for the induction of both posterior and dorsal follicle cell fates. cni is probably required in the oocyte for the production of the inducing signal, but as mutations do not affect grk localisation to the posterior of the oocyte cni must act at a different step in the pathway. (Gonzalez-Reyes et al., 1995) Comparison of protein sequence demonstrates that six conservative amino acid changes distinguish cni from Dvir\cni. (Roth et al., 1995) cni is required for Egfr signalling in oogenesis. This signalling pathway is required for dorsal ventral patterning and for the correct anterior posterior polarisation of the oocyte in midoogenesis. (Roth et al., 1995) Displays epistatic interactions with sqd alleles. (Kelley, 1993) 2 alleles are discussed but are not named. (Ashburner et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057720 NM_165151 RefSeq (Proteins) • NP_477068 NP_723959 DDBJ / EMBL / GenBank • AAA86527 AAF45003 AAF53521 AAF53522 AC092398 AE003415 AI516860 BH610007 U28069 Entrez Gene - A searchable database of RefSeq genes. • 34967 UniProtKB/Swiss-Prot • P49858
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cornichon (IPR003377)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0000339 DRSC - Results from RNAi screens. • FBgn0000339 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000339 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5855-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000339 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34967 InParanoid A subset of ortholog calls from InParanoid. • AAEL007332-PA Aedes aegypti (mosquito) AGAP008974-PA Anopheles gambiae (mosquito) XP_001944808.1 Acyrthosiphon pisum (pea aphid) At3g12180.1 Arabidopsis thaliana (wall cress) 18374 Batrachochytrium dendrobatidis (chytrid fungus) 264252 Branchiostoma floridae (lancelet) ENSBTAP00000025975 Bos taurus (bovine) CAL0004990 Candida albicans (a form of yeast) CN00508 Caenorhabditis brenneri (small nematode) CBP02306 Caenorhabditis briggsae (nematode) CE23961 Caenorhabditis elegans (worm) ENSCAFP00000021971 Canis familiaris (dog) CAGL0I00440g Candida glabrata (haploid yeast) JA15252 Caenorhabditis japonica (nematode) cn03711 Cryptococcus neoformans (yeast-like fungus) CPIJ009353 Culex pipens (mosquito) ENSCPOP00000007627 Cavia porcellus (guinea pig) RP16129 Caenorhabditis remanei (nematode) ENSCSAVP00000000318 Ciona savignyi (sedentary tunicate) 223226 Capitella spl (polychaete worm) DDB0201912 Dictyostelium discoideum (amoeba) DEHA2F02618g Debaryomyces Hansenii (yeast) 189492 Daphnia pulex (daphnia) ENSDARP00000091020 Danio rerio (zebra fish) ENSECAP00000016706 Equus caballus (horse) XP_651069 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015581 Gymnopilus aculeatus (mushroom) ENSGALP00000019918 Gallus gallus (chicken) 185743 Hypsipyla robusta (cedar shoot borer) ENSP00000216416 Homo sapiens (human) KLLA0C05478g Kluyveromyces lactis (yeast) 107610 Lottia gigantea (owl limpet) LmjF32.3840 Leishmania major (virus) 32837 Monocosta brevicollis (choanoflagellate) ENSMODP00000014567 Monodelphis domestica (gray opossum) ENSMMUP00000016176 Macaca mulatta (rhesus monkey) ENSMUSP00000015903 Mus musculus (house mouse) 131022 Nematostella vectensis (starlet anemone) XP_001607460.1 Nasonia vitripennis (wasp) ENSOANP00000002320 Ornithorynchus anatinus (platypus) ENSORLP00000011506 Oryzias latipes (japanese killifish) PHUM003239-PA Pediculus humanus (human body louse) PP02679 Pristionchus pacificus (nematode) ENSPPYP00000006623 Pongo pygmaeus (orangutan) 81111 Phytophthora ramorum (sudden oak death pathogen) 158531 Phytophthora sojae (root rot pathogen) ENSPTRP00000010787 Pan troglodytes (chimpanzee) ENSRNOP00000013331 Rattus norvegicus (norway rat) YGL054C Saccharomyces cerevisiae (budding yeast) Smp_082990 Schistosoma mansoni (trematode parasite) SPAC30C2.05 Schizosaccharomyces pombe (fission yeast) XP_787571.2 Strongylocentrotus purpuratus (purple sea urchin) 32287 Trichoplax adhaerens (metazoa) XP_974854.1 Tribolium castaneum (red flour beetle) Tc00.1047053503823.80 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510283.110 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000022544 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026013 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000026714 Xenopus tropicalis (frog) YALI0F12001g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/cornichon1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34967 modMine - Data generated by the modENCODE project. • FBgn0000339 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14946 LH23588 ISCW007754 FBgn0236712 FBgn0225678 FBgn0204340 FBgn0193337 FBgn0172818 JGI_V11_189492 FBgn0079179 FBgn0151692 FBgn0137445 FBgn0118910 FBgn0116306 FBgn0092350 CPIJ009353 ACYPI005267 ACYPI000183 GB18925 AGAP008974 AAEL007332 AAEL007327 PB24045 PHUM348080 GLEAN_13453
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	anon-35Fe   BG:DS02740.13 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG5855 (Keleman et al., 2009.8.5, Cammarato et al., 2011) cni (Pizette et al., 2009, Snee and Macdonald, 2009, Kugler et al., 2009, Dworkin et al., 2009) Cni (Bokel et al., 2006, Castro et al., 2007) IV (Dawson et al., 1995) spnG
Name Synonym	cornichon (Snee and Macdonald, 2009, Cammarato et al., 2011) Cornichon (Bokel et al., 2006, Castro et al., 2007) spindle-G
Secondary FlyBase IDs
	FBgn0020601
References ( 73 )
Generate a list of	All references relating to this gene ( 73 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 4 ) Review  ( 21 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...