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Gene Dmel\comt

General Information
Symbol	Dmel\comt	Species	D. melanogaster
Name	comatose	Annotation symbol	CG1618
Feature type	protein_coding_gene	FlyBase ID	FBgn0000346
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	dnsf1, NSF, com, dNSF-1, dNSF
Genomic Location
Chromosome (arm)	X	Recombination map	1-40.1
Cytogenetic map	11E8-11E8	Sequence location	X:13,153,030..13,156,521 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene comatose is referred to in FlyBase by the symbol Dmel\comt (CG1618, FBgn0000346). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ATPase activity. There is experimental evidence that it is involved in the biological process: Golgi organization; regulation of short-term neuronal synaptic plasticity; phagocytosis, engulfment. 38 alleles are reported. The phenotypes of these alleles are annotated with: Golgi stack; retina; Golgi apparatus; central nervous system; NMJ bouton; synapse; embryonic/larval heart. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, VAT, N-terminal; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; Aspartate decarboxylase-like fold; Cell division protein 48, Cdc48, domain 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639825_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of comt. Gene sequence location is X:13153030..13156521.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	comt: comatose (J.C. Hall) Larvae or adults become paralyzed when exposed to high temperatures, but this requires many seconds for induction; recovery from immobility on lowering of temperature is slow and directly correlated with duration of paralysis; most of the comt alleles do not induce relatively rapid paralysis until 38 (Siddiqi and Benzer, 1976), but two (com101, com102) cause pass-out at 29 (Homyk, Szidonya, and Suzuki, 1980, Mol. Gen. Genet. 177: 553-65); the mutations induce graded decrease and recovery of function of synapses at neuromuscular junctions as temperature is raised and lowered (Siddiqi and Benzer, 1976); several alleles are cold sensitive for paralysis as well as heat sensitive (Siddiqi and Benzer, 1976). ERG normal (Homyk and Pye, 1989, J. Neurogenet. 5: 37-48).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN25639 HFA20319
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11E8-11E8   Limits computationally determined from genome sequence between P{EP}EP1461 and P{EP}CG1640EP1626
Experimentally Determined Cytological Location
Cytogenetic map Notes References 11D9-11E4     (Ordway, 1994.5.4) 87F12-88A3   (determined by in situ hybridisation)   (Boulianne and Trimble, 1995) 11D-11E   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location	1-40.1
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\comt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) comt-RA FBtr0073754  NM_080138   3111   745
Additional Transcript Data & Comments
Reported size (kB)	3.2 (northern blot) (Ordway et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein comt-PA   FBpp0073585   82.6   745   7.52     NP_524877   AAF48244
Additional Polypeptide Data & Comments
Reported size (kDa)	745 (aa) (Ordway et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA-type, VAT, N-terminal (IPR003338) ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Cell division protein 48, Cdc48, domain 2 (IPR004201) Aspartate decarboxylase-like fold (IPR009010)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202417   AA540794   AA567536   AA568010   AA694993   AA697472   AA698685   AA949609   AE014298 AAF48244   AI063373   AI108546   AI114254   AI135786   AI387352   AI388906   AI403368   AI403806   AI513371   AI517636   AI517688   AI532569   AI944516   BG638233   BI237381   BI565051   BI608037   BI612918   BI614353   BI614774   BI616459   BI625236   BI629439   BT010259 AAQ23577   BT023784   CO176902   CO179423   CO185356   CO186093   CO189912   CO263011   CO263708   CO274503   CO306152   CO309204   CO320083   EC057341   EC067131   EC071015   EC195465   EC200716   EC201305   EC215067   EC223688   EC226215   EC228833   EC231173   EC241753   EC242921   EC244362   EC249687   GH827340   GH929532   U09373 AAA83413
UniProtKB/Swiss-Prot	P46461
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   presumptive embryonic/larval central nervous system   (Ordway et al., 1994) larval stage     (Ordway et al., 1994) adult stage     (Ordway et al., 1994)
Additional Descriptive Data
	comt transcripts are detected in RNA from larvae and adults on northern blots. In situ hybridization in embryos shows expression throughout the embryo with strong staining in the CNS. (Ordway et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000346    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000346 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000346 expression level Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (600) embryo 02-04hr  (281) embryo 04-06hr  (130) embryo 06-08hr  (207) embryo 08-10hr  (310) embryo 10-12hr  (540) embryo 12-14hr  (600) embryo 14-16hr  (905) embryo 16-18hr  (1271) embryo 18-20hr  (1511) embryo 20-22hr  (1533) embryo 22-24hr  (1657) larva L1  (1651) larva L2  (655) larva L3 12hr old  (251) larva L3 puffstage 1-2  (299) larva L3 puffstage 3-6  (432) larva L3 puffstage 7-9  (501) white prepupae new  (532) white prepupae 12hr  (836) white prepupae 24hr  (1121) pupae 2d postWPP  (1467) pupae 3d postWPP  (2341) pupae 4d postWPP  (2816) adult male 01day  (2714) adult male 05day  (2988) adult male 30day  (2802) adult female 01day  (1304) adult female 05day  (725) adult female 30day  (733) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr  (1511) embryo 20-22hr  (1533) embryo 22-24hr  (1657) larva L1  (1651) larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP  1467 pupae 3d postWPP  (2341) pupae 4d postWPP  (2816) adult male 01day  (2714) adult male 05day  (2988) adult male 30day  (2802) adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000346 expression level Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (600) embryo 02-04hr  (281) embryo 04-06hr  130 embryo 06-08hr  (207) embryo 08-10hr  (310) embryo 10-12hr  (540) embryo 12-14hr  (600) embryo 14-16hr  (905) embryo 16-18hr  (1271) embryo 18-20hr  (1511) embryo 20-22hr  (1533) embryo 22-24hr  (1657) larva L1  (1651) larva L2  (655) larva L3 12hr old  (251) larva L3 puffstage 1-2  (299) larva L3 puffstage 3-6  (432) larva L3 puffstage 7-9  (501) white prepupae new  (532) white prepupae 12hr  (836) white prepupae 24hr  (1121) pupae 2d postWPP  (1467) pupae 3d postWPP  (2341) pupae 4d postWPP  (2816) adult male 01day  (2714) adult male 05day  (2988) adult male 30day  (2802) adult female 01day  (1304) adult female 05day  (725) adult female 30day  (733) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr  1511 embryo 20-22hr  1533 embryo 22-24hr  1657 larva L1  1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP  1467 pupae 3d postWPP  2341 pupae 4d postWPP  (2816) adult male 01day  (2714) adult male 05day  (2988) adult male 30day  (2802) adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    600 embryo 02-04hr    281 embryo 04-06hr    130 embryo 06-08hr    207 embryo 08-10hr    310 embryo 10-12hr    540 embryo 12-14hr    600 embryo 14-16hr    905 embryo 16-18hr    1271 embryo 18-20hr    1511 embryo 20-22hr    1533 embryo 22-24hr    1657 larva L1    1651 larva L2    655 larva L3 12hr old    251 larva L3 puffstage 1-2    299 larva L3 puffstage 3-6    432 larva L3 puffstage 7-9    501 white prepupae new    532 white prepupae 12hr    836 white prepupae 24hr    1121 pupae 2d postWPP    1467 pupae 3d postWPP    2341 pupae 4d postWPP    2816 adult male 01day    2714 adult male 05day    2988 adult male 30day    2802 adult female 01day    1304 adult female 05day    725 adult female 30day    733 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000346    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000346 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000346 expression level Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head    1030.9 Adult Eye    1466.1 Adult Brain    1938 Adult Thoracic-Abdominal Ganglion    2863.3 Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (614.1) Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head  (1030.9) Adult Eye  (1466.1) Adult Brain  (1938) Adult Thoracic-Abdominal Ganglion  (2863.3) Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head  1030.9 Adult Eye  (1466.1) Adult Brain  (1938) Adult Thoracic-Abdominal Ganglion  (2863.3) Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head    1030.9 Adult Eye    1466.1 Adult Brain    1938 Adult Thoracic-Abdominal Ganglion    2863.3 Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000346 expression level Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head    1030.9 Adult Eye    1466.1 Adult Brain    1938 Adult Thoracic-Abdominal Ganglion    2863.3 Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head  (1030.9) Adult Eye  (1466.1) Adult Brain  (1938) Adult Thoracic-Abdominal Ganglion  (2863.3) Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head  1030.9 Adult Eye  1466.1 Adult Brain  (1938) Adult Thoracic-Abdominal Ganglion  (2863.3) Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    614.1 Larval Midgut    6 Larval Hindgut    7.5 Larval Malpighian Tubules    1.7 Larval Fat Body no informative data Larval Salivary Gland    2 Larval Trachea    35.175 Larval Carcass no informative data Adult Head    1030.9 Adult Eye    1466.1 Adult Brain    1938 Adult Thoracic-Abdominal Ganglion    2863.3 Adult Crop    20.2 Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4.6 Adult Fat Body    7 Adult Salivary Gland    8.8 Adult Heart    8.875 Adult VirginFemale Spermatheca    3.4 Adult InseminatedFemale Spermatheca    7.6 Adult Ovary    117.2 Adult Testis    261.6 Adult Male Accessory Gland    4.8 Adult Carcass    70.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1030.9   NA  Eye    1466.1   NA  Brain    1938   614.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2863.3   NA  Crop    20.2   6  Midgut    4.7   7.5  Hindgut    no informative data   1.7  Malpighian Tubules    4.6   no informative data  Fat Body    7   2  Salivary Gland    8.8   NA  Heart    8.875   35.175  Trachea    NA   NA  VirginFemale Spermatheca    3.4   NA  InseminatedFemale Spermatheca    7.6   NA  Ovary    117.2   NA  Testis    261.6   NA  Male Accessory Gland    4.8   no informative data  Carcass    70.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000346 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1618-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for comt Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal comt191 comtG8 lethal (with Df(1)C246) comtclp lethal (with Df(1)wy26) comtclp lethal | germline clone | pharate adult stage | recessive comt3-13-3 comtclp lethal | larval stage | heat sensitive comt6 lethal | larval stage | recessive comtclp lethal | pharate adult stage | recessive comt3-13-3 comtclp lethal | pharate adult stage | recessive | heat sensitive comt4 comt6 lethal | recessive comt133 comt1121 comtclp comtLED viable comtG4 viable, with Scer\GAL4pnr-MD237 comtGD17039 Other Phenotypes Allele bang sensitive comt1 locomotor behavior defective comt1 mating defective comt1 neuroanatomy defective | heat sensitive comt4 neuroanatomy defective | larval stage comtclp neurophysiology defective | heat sensitive comt1 comt4 comt6 comtDN34 comtDN47 comtDN48 paralytic comt4 comt5 comt6 paralytic | heat sensitive comt1 comt1ST7 comt4 comt6 comtDN34 comtDN47 comtDN48 comtJN17 comtX91 comtX238 paralytic | heat sensitive (with comt1) comtclp paralytic | heat sensitive (with comt4) comtclp paralytic | heat sensitive (with comt6) comtclp paralytic | heat sensitive (with comtclp) comt1 comt4 comt6 paralytic | recessive comte1 paralytic | recessive | heat sensitive comt1 comt4 comt6 short lived | heat sensitive comtG4 uncoordinated | adult stage | recessive comt3-13-3 comtclp uncoordinated | adult stage | recessive | heat sensitive comt6 uncoordinated | heat sensitive comtG4 uncoordinated | larval stage | recessive comt3-13-3 comt4 uncoordinated | larval stage | recessive | heat sensitive comt6 visual behavior defective | heat sensitive comt1 comt4 comt6 wild-type comths.PP Phenotype manifest in Allele central nervous system comtND4 comtND5 comtND6 dorsal medial muscle | heat sensitive comt6 embryonic/larval heart comtunspecified Golgi apparatus comths.PP Golgi stack comt4 Golgi stack | ectopic comths.PP NMJ bouton comtclp optic cartridge & synaptic vesicle comt4 retina comt6 retina | heat sensitive comt1 comt4 synapse comt4 synaptic vesicle | heat sensitive comt1 comt4 comt6
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of comt Class Mutagen Stocks Known lesion comt6 ethyl methanesulfonate 1 Yes comtclp loss of function allele 1 Yes comt1121 0 Yes comt133 0 Yes comt191 0 Yes comt1 ethyl methanesulfonate 0 Yes comt1ST7 0 -- comt2 ethyl methanesulfonate 0 -- comt3-13-3 0 Yes comt3 ethyl methanesulfonate 0 -- comt4 ethyl methanesulfonate 0 Yes comt5 ethyl methanesulfonate 0 -- comtDN34 0 Yes comtDN47 0 Yes comtDN48 0 Yes comte1 ethyl methanesulfonate 0 Yes comtG4 0 Yes comtG8 gamma ray 0 Yes comtJN17 0 Yes comtLED 0 Yes comtND4 0 -- comtND5 0 -- comtND6 0 -- comtSu1 ethyl methanesulfonate 0 Yes comtts17 0 -- comtts53 0 -- comtunspecified 0 -- comtX238 0 Yes comtX91 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of comt Class Mutagen Stocks Known lesion comtGD17039 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comtHMS01261 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comtJF01233 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comtJF01459 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comtKK104679 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes comtGD8777 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes comths.PP in vitro construct - regulatory fusion 0 Yes comtScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes comtScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)C246 (Sanyal and Krishnan, 2001) Df(1)wy26 (Dellinger et al., 2000, Sanyal and Krishnan, 2001)
Duplicated in	Dp(1;3)DC267 (Popodi et al., 2010-)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8777} NA P{GD17039} NA P{KK104679} NA P{TRiP.HMS01261} NA P{TRiP.JF01233} NA P{TRiP.JF01459} NA P{UAS-comt.G} NA P{UAS-comt-FLAG.K} NA heat-shock construct P{hsp70-NSF} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
Golgi organization inferred from mutant phenotype (Kondylis et al., 2001) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) regulation of short-term neuronal synaptic plasticity inferred from direct assay (Kawasaki and Ordway, 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATPase activity traceable author statement (Kondylis et al., 2001) ATP binding inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960 (FlyBase Curators et al., 2004-) nucleoside-triphosphatase activity inferred from electronic annotation with InterPro:IPR003593 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ER to Golgi vesicle-mediated transport non-traceable author statement (Swiss-Prot Project Members, 1995.9.1) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic vesicle priming non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:P46460 (FlyBase, 1992-) non-traceable author statement (Littleton et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions comt allele Gene References comt1 cac (Dellinger et al., 2000) ovr (Dellinger et al., 2000) comt3-13-3 Nsf2 (Golby et al., 2001) comt4 cac (Dellinger et al., 2000) Nsf2 (Golby et al., 2001) ovr (Dellinger et al., 2000) para (Littleton et al., 2001) shi (Littleton et al., 2001) comt6 Nsf2 (Golby et al., 2001) comtclp Nsf2 (Golby et al., 2001) comths.PP Nsf2 (Golby et al., 2001) comtunspecified cac (Dellinger et al., 1999) unspecified cac (Chan et al., 2002) Snap (Babcock et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70577 DroID - A comprehensive database of gene and protein interactions. • FBgn0000346 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47091
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21411 Dere\GG17764 Dmoj\GI21685 Dper\GL13314 Dpse\GA22832 Dsim\GD17110 Dvir\GJ15864 Dwil\GK18341 Dyak\GE17054
Curated drosophilid orthologs	Dpse\GA14048
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001616-PA Aedes aegypti (mosquito) XP_001120201.1 Apis mellifera (honey bee) 17900 Batrachochytrium dendrobatidis (chytrid fungus) XP_001896878.1 Brugia malayi (roundworm nematode) BGIBMGA000447-PA Bombyx mori (silk worm) CAL0000029 Candida albicans (a form of yeast) CN24330 Caenorhabditis brenneri (small nematode) CN29100 Caenorhabditis brenneri (small nematode) CBP36825 Caenorhabditis briggsae (nematode) CE19925 Caenorhabditis elegans (worm) CAGL0M01782g Candida glabrata (haploid yeast) ENSCINP00000014219 Ciona intestinalis (sea squirt) CMQ243C Cyanidioschyzon merolae (red alga) CPIJ003150 Culex pipens (mosquito) ENSCPOP00000008432 Cavia porcellus (guinea pig) ENSCSAVP00000010104 Ciona savignyi (sedentary tunicate) 178991 Capitella spl (polychaete worm) DEHA2G10252g Debaryomyces Hansenii (yeast) 60285 Daphnia pulex (daphnia) ENSDARP00000000690 Danio rerio (zebra fish) XP_656792 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008641 Gymnopilus aculeatus (mushroom) KLLA0C14520g Kluyveromyces lactis (yeast) 207527 Lottia gigantea (owl limpet) LmjF20.0810 Leishmania major (virus) 21577 Monocosta brevicollis (choanoflagellate) 171134 Nematostella vectensis (starlet anemone) ENSORLP00000015079 Oryzias latipes (japanese killifish) LOC_Os05g44310.1 Oryza sativa (asian rice) PFC0140c Plasmodium falciparum (protozoal parasite) PHUM000926-PA Pediculus humanus (human body louse) PP02641 Pristionchus pacificus (nematode) 198701 Physcomitrella patens (moss) 83865 Phytophthora ramorum (sudden oak death pathogen) 132189 Phytophthora sojae (root rot pathogen) 831118 Populus trichocarpa (black cottonwood) PVX_119275 Plasmodium vivax (protozoal parasite) ENSRNOP00000006361 Rattus norvegicus (norway rat) 4742126 Sorghum bicolor (sorghum) YBR080C Saccharomyces cerevisiae (budding yeast) SPAC1834.11c Schizosaccharomyces pombe (fission yeast) 22168 Trichoplax adhaerens (metazoa) TA11700 Theileria annulata (apicomplexan parasite) XP_001811586.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008806 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016191 Takifugu rubripes (pufferfish Takifugu) YALI0E29249g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH20300 ISCW024697 ISCW007723 FBgn0241531 FBgn0234538 FBgn0220339 FBgn0215067 FBgn0203051 FBgn0201490 FBgn0191944 FBgn0188680 FBgn0180761 JGI_V11_60285 JGI_V11_240520 JGI_V11_240595 JGI_V11_48480 JGI_V11_240599 JGI_V11_118650 FBgn0244234 FBgn0077294 FBgn0161672 FBgn0150920 FBgn0147139 FBgn0144415 FBgn0013998 FBgn0132094 FBgn0121518 FBgn0109986 FBgn0109247 FBgn0098413 FBgn0093419 CPIJ003150 BGIBMGA000447 ACYPI009908 GB12144 AGAP012684 AAEL001616 PB23268 PHUM047300 PHUM047310 GLEAN_12279
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	26708 comt6 27890 comtclp/FM7a 31470 y1 v1; P{TRiP.JF01233}attP2 31666 y1 v1; P{TRiP.JF01459}attP2 34913 y1 sc* v1; P{TRiP.HMS01261}attP2
VDRC	v105552 P{KK104679}VIE-260B v46483 w1118 P{GD17039}v46483
Genomic Clones ( 2 )
	BACR13N03 BACR27O05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 58 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD09622 RE33604
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03134 GH07730 GH11042 GH13663 GH17858 GH19941 GH22789 GH23320 GH26551 GH28674 GH28736 GM01915 HL01416 HL02139 HL02568 HL05471 LD02590 LD29567 RH12165 RH41921 RH43713 RH44240 RH46415 RH58307 RH62708 RH65535 SD04124
Other clones	15536 64332 64612 74321 144347 155744 158057 177290 bs03d10 CK01.5A.D10 CK01.15D.C1 CK01.56B.F8 CK01.75D.D6 CK01.103D.F6 CK01.107A.C2 EK008645 EK015809 EK045556 EK051544 EK059347 EK087055 EK089341 EK114309 EK250362 EK260640 EK282129 LD20612 RP003321746 RP003439694
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000346 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47091
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: comt CG1618 (Bayraktaroglu, 2000.4.12)
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) comt and Nsf2 exhibit similar functional properties but have evolved distinct tissue-specific roles. comt is required in the nervous system beginning at the adult stage of development whereas Nsf2 is required in the mesoderm beginning at the first larval instar. The comt and Nsf2 proteins can functionally substitute for one another. (Golby et al., 2001) comt normally dissociates and recycles SNARE proteins during the interval between exocytosis and endocytosis in the synaptic vesicle cycle. (Littleton et al., 2001) Paralysis in comt mutant flies is activity dependent. (Sanyal et al., 1999) Evidence of multiple, highly related isoforms of NSF in a single species suggests that in some tissue membranes fusion and/or secretion has a specific role during development. (Boulianne and Trimble, 1995) Mutations of comt are defective in one component of the molecular machinery mediating vesicle targetting and fusion, N-ethylmaleimide-sensitive fusion protein (NSF). comt exhibits an apparent defect in synaptic transmission which is the first functional evidence that NSF in involved in this process. (Pallanck et al., 1995) Drosophila has a second N-ethylmaleimide-sensitive fusion protein (NSF) homolog, Nsf2. comt and Nsf2 display overlapping but different temporal expression patterns. (Pallanck et al., 1995) comt gene has been cloned and the gene product characterised. (Ordway et al., 1994) The neurosecretory apparatus of the presynaptic nerve terminal contains a core complex of conserved secretory proteins, comt is a component this complex. (Pallanck et al., 1994) Larvae or adults become paralyzed when exposed to high temperatures, but this requires many seconds for induction; recovery from immobility on lowering of temperature is slow and directly correlated with duration of paralysis; most of the comt alleles do not induce relatively rapid paralysis until 38oC (Siddiqi and Benzer, 1976), but two (comt2, comt3) cause pass-out at 29oC (Homyk, Szidonya and Suzuki, 1980); the mutations induce graded decrease and recovery of function of synapses at neuromuscular junctions as temperature is raised and lowered (Siddiqi and Benzer, 1976); several alleles are cold-sensitive for paralysis as well as temperature-sensitive (Siddiqi and Benzer, 1976). ERG normal (Homyk and Pye, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080138 RefSeq (Proteins) • NP_524877 DDBJ / EMBL / GenBank • AAA83413 AAF48244 AAQ23577 AI944516 BI237381 BT010259 U09373 Entrez Gene - A searchable database of RefSeq genes. • 47091 UniProtKB/Swiss-Prot • P46461
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA-type, VAT, N-terminal (IPR003338) ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) ATPase, AAA-type, conserved site (IPR003960) Cell division protein 48, Cdc48, domain 2 (IPR004201) Aspartate decarboxylase-like fold (IPR009010)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70577 DroID - A comprehensive database of gene and protein interactions. • FBgn0000346 DRSC - Results from RNAi screens. • FBgn0000346 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000346 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1618-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000346 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47091 InParanoid A subset of ortholog calls from InParanoid. • AAEL001616-PA Aedes aegypti (mosquito) XP_001120201.1 Apis mellifera (honey bee) 17900 Batrachochytrium dendrobatidis (chytrid fungus) XP_001896878.1 Brugia malayi (roundworm nematode) BGIBMGA000447-PA Bombyx mori (silk worm) CAL0000029 Candida albicans (a form of yeast) CN24330 Caenorhabditis brenneri (small nematode) CN29100 Caenorhabditis brenneri (small nematode) CBP36825 Caenorhabditis briggsae (nematode) CE19925 Caenorhabditis elegans (worm) CAGL0M01782g Candida glabrata (haploid yeast) ENSCINP00000014219 Ciona intestinalis (sea squirt) CMQ243C Cyanidioschyzon merolae (red alga) CPIJ003150 Culex pipens (mosquito) ENSCPOP00000008432 Cavia porcellus (guinea pig) ENSCSAVP00000010104 Ciona savignyi (sedentary tunicate) 178991 Capitella spl (polychaete worm) DEHA2G10252g Debaryomyces Hansenii (yeast) 60285 Daphnia pulex (daphnia) ENSDARP00000000690 Danio rerio (zebra fish) XP_656792 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008641 Gymnopilus aculeatus (mushroom) KLLA0C14520g Kluyveromyces lactis (yeast) 207527 Lottia gigantea (owl limpet) LmjF20.0810 Leishmania major (virus) 21577 Monocosta brevicollis (choanoflagellate) 171134 Nematostella vectensis (starlet anemone) ENSORLP00000015079 Oryzias latipes (japanese killifish) LOC_Os05g44310.1 Oryza sativa (asian rice) PFC0140c Plasmodium falciparum (protozoal parasite) PHUM000926-PA Pediculus humanus (human body louse) PP02641 Pristionchus pacificus (nematode) 198701 Physcomitrella patens (moss) 83865 Phytophthora ramorum (sudden oak death pathogen) 132189 Phytophthora sojae (root rot pathogen) 831118 Populus trichocarpa (black cottonwood) PVX_119275 Plasmodium vivax (protozoal parasite) ENSRNOP00000006361 Rattus norvegicus (norway rat) 4742126 Sorghum bicolor (sorghum) YBR080C Saccharomyces cerevisiae (budding yeast) SPAC1834.11c Schizosaccharomyces pombe (fission yeast) 22168 Trichoplax adhaerens (metazoa) TA11700 Theileria annulata (apicomplexan parasite) XP_001811586.1 Tribolium castaneum (red flour beetle) ENSTNIP00000008806 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016191 Takifugu rubripes (pufferfish Takifugu) YALI0E29249g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/nsf1-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47091 modMine - Data generated by the modENCODE project. • FBgn0000346 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH20300 ISCW024697 ISCW007723 FBgn0241531 FBgn0234538 FBgn0220339 FBgn0215067 FBgn0203051 FBgn0201490 FBgn0191944 FBgn0188680 FBgn0180761 JGI_V11_60285 JGI_V11_240520 JGI_V11_240595 JGI_V11_48480 JGI_V11_240599 JGI_V11_118650 FBgn0244234 FBgn0077294 FBgn0161672 FBgn0150920 FBgn0147139 FBgn0144415 FBgn0013998 FBgn0132094 FBgn0121518 FBgn0109986 FBgn0109247 FBgn0098413 FBgn0093419 CPIJ003150 BGIBMGA000447 ACYPI009908 GB12144 AGAP012684 AAEL001616 PB23268 PHUM047300 PHUM047310 GLEAN_12279
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG1618 (Dunne et al., 2002, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) CG 1618 (Dorer et al., 2006) com (Morgan, 1996, Parfitt et al., 1995, Homyk and Pye, 1989, Ganetzky, 1984, Siddiqi and Benzer, 1976, ) comt (Littleton, 2005.8.1, Stroschein-Stevenson et al., 2006, Lagow et al., 2007, Wang et al., 2004, Huang et al., 2006, Junion et al., 2007, Dorer et al., 2006, Sanyal, 2009.7.28, Sanyal and Krishnan, 2001, Popodi et al., 2010-) DmNSF (Frohlich, 2001) dNSF (Bate and Broadie, 1995, Pallanck et al., 1994, ) dNSF-1 (Muller et al., 2002, Mohtashami and Trimble, 1998, Pallanck et al., 1995, Boulianne and Trimble, 1995) dnsf1 (Dunne et al., 2002, Schotman et al., 2008) dNSF1 (Dunne et al., 2002, Kondylis et al., 2001, Dunne and Rabouille, 2001, Tolar et al., 1999, Kawasaki and Ordway, 1998, Wu and Bellen, 1997, Babcock et al., 2004, Kawasaki and Ordway, 2009) dNsf1 (Golby et al., 2001) NSF (Swaffield and Purugganan, 1997, Kawasaki and Ordway, 2009, Dorer et al., 2006) Nsf (Linial and Parnas, 1996, Whiteheart and Kubalek, 1995, Ordway et al., 1994, ) NSF-1 (Adolfsen et al., 2004) NSF1 (Rabouille and Dunne, 2001)
Name Synonym	comatose (Lagow et al., 2007, Huang et al., 2006, Sanyal and Krishnan, 2001, Kawasaki and Ordway, 2009, Freeman et al., 2011) NEM-sensitive fusion protein   N-ethylmaleimide-sensitive fusion protein (Ordway, 1994.5.4)
Secondary FlyBase IDs
	FBgn0011678 FBgn0030463
References ( 95 )
Generate a list of	All references relating to this gene ( 95 )
List References by type	Research paper  ( 45 ) Supplementary material  ( 5 ) Review  ( 12 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 16 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Letter  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 )
Recent research papers ( 3 )
	Freeman et al., 2011, Mol. Cell. Neurosci. 46(2): 535--547 NFAT regulates pre-synaptic development and activity-dependent plasticity in Drosophila. [FBrf0212894] Yu et al., 2011, Mol. Cell. Neurosci. 47(1): 19--27 Activity-dependent interactions of NSF and SNAP at living synapses. [FBrf0213595] Freeman et al., 2010, Brain Res. 1326: 15--29 A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila. [FBrf0210453] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...