Gene model reviewed during 5.46
Probably ubiquitinated: degraded following egg activation by the anaphase promoting complex/cyclosome (APC/C).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cort using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cort in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Eggs derived from mutant females arrest in metaphase of meiosis II.
cort and grau genes are necessary for bcd protein expression. Mutations in cort impair bcd and other maternal patterning genes mRNA translation by disrupting cytoplasmic polyadenylation. bcd mRNA expression, localisation or processing are not affected. Mutations in cort do not block poly(A)-independent translational activation of nos mRNA. Phenotypic analysis demonstrates cort is required for initiation of development. Homozygous germ-line clones indicate cort is required in the germ-line. Temperature shift studies reveal cort is required at multiple stages of embryonic development.