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Gene Dmel\cpo

General Information
Symbol	Dmel\cpo	Species	D. melanogaster
Name	couch potato	Annotation symbol	CG31243
Feature type	protein_coding_gene	FlyBase ID	FBgn0000363
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	CG18435, CG12349
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	90D1-90E1	Sequence location	3R:13,745,555..13,844,503 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene couch potato is referred to in FlyBase by the symbol Dmel\cpo (CG31243, FBgn0000363). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: synaptic transmission; dormancy process; olfactory behavior; cellular process. 99 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult heart, larval salivary gland, adult spermathecae, adult male reproductive system, adult carcass. Gene sequence location is 3R:13745555..13844503.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA13265 References Reis et al., 2010, PLoS Genet. 6(11): e1001206
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 90D1-90E1   Limits computationally determined from genome sequence between P{PZ}l(3)0788207882 and P{EP}cpoEP3679
Experimentally Determined Cytological Location
Cytogenetic map Notes References 90D-90D   (determined by in situ hybridisation)   (Zhang et al., 2002) 90D1-90D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 90D1-90D2   (determined by in situ hybridisation)   (Forjanic et al., 1997) 90D-90E   (determined by in situ hybridisation)   (Ranz et al., 1997) 90D1-90D4   (determined by in situ hybridisation)   (Bellen, 1992) 65D4-65D5   66D10--13 67E5--7 85C3--5 90D4--5 96C8--9 96C8--D1   (BDGP Project Members, 1994-1999) 90D2-90E2   (determined by in situ hybridisation)   (Bellen et al., 1991) 90D-90D   (determined by in situ hybridisation)   (Bellen et al., 1992) 90D1-90E1   (determined by in situ hybridisation)   (Bellen et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cpo for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Unconventional translation start (CUC) postulated; GenBank accession Z14974, FBrf0056119. Gene model reviewed during 5.39 Gene merge based on EST data gene_with_non_canonical_start_codon ; SO:0001739 gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cpo-RA FBtr0083534  NM_169782   5084   615 cpo-RB FBtr0083537  NM_169783   6059   615 cpo-RI FBtr0300241  NM_080105   6130   615 cpo-RJ FBtr0300242  NM_001170169   8286   616 cpo-RK FBtr0306756     6115   615 cpo-RL FBtr0306757     4467   615 cpo-RM FBtr0308290     8288   616
Additional Transcript Data & Comments
Reported size (kB)	7.8, 5.0, 4.5 (northern blot); 3.035 (longest cDNA) (Bellen et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cpo-PA   FBpp0082958   64.3   615   9.41     NP_732283   AAF55485 cpo-PB   FBpp0082961   64.3   615   9.41     NP_732284   AAF55484 cpo-PI   FBpp0289474   64.3   615   9.41     NP_524844   AAN13754 cpo-PJ   FBpp0289475   64.5   616   9.41     NP_001163640   ACZ94936 cpo-PK   FBpp0297679   64.3   615   9.41       cpo-PL   FBpp0297680   64.3   615   9.41       cpo-PM   FBpp0300609   64.5   616   9.41
Additional Polypeptide Data & Comments
Reported size (kDa)	51, 50 (kD) (Bellen et al., 1992)
Comments	The correspondence between cpo mRNAs and proteins is not clear. Three proteins are predicted from cDNAs but only one 50kD band is detected with the cpo antibody. The RNA-binding-protein consensus domain in cpo protein is most similar to that of a human brain protein (HuD) and Drosophila elav. (Bellen et al., 1992) The 64kD cpo protein is predicted from the "61.1" class of cpo cDNA. The cpo antibody was made against a protein fragment that is common to the predicted 64kD and 56kD proteins but it recognizes only a 50kD species on immunoblots of embryonic extracts. The RNA-binding-protein consensus domain in cpo protein is most similar to that of a human brain protein (HuD) and Drosophila elav. (Bellen et al., 1992) The 51kD cpo protein is predicted from the "17" class of cpo cDNA. In contrast to the other predicted cpo proteins, it lacks the RNA-binding-protein consensus domain. (Bellen et al., 1992) The 56kD cpo protein is predicted from the "61.2" class of cpo cDNA. The cpo antibody was made against a protein fragment that is common to the predicted 64kD and 56kD proteins but it recognizes only a 50kD species on immunoblots of embryonic extracts. The RNA-binding-protein consensus domain in cpo protein is most similar to that of a human brain protein (HuD) and Drosophila elav. (Bellen et al., 1992) One of several products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697436   AA697937   AE014297 AAF55484   AE014297 AAF55485   AE014297 AAN13754   AE014297 ACZ94936   AF006652   AQ073308   AQ073957   AY129455 AAM76197   BF486717   BG634976   BI214589   BI235126   BI235270   BI241136   BI356174   BI364185   BI365770   BI367747   BI372764   BI372837   BI564194   BI577048   BI577487   BI580833   BI621117   BT001569 AAN71324   BT120130   CO187176   CO188881   CO196584   CO267431   CO268398   CO268428   CO273221   CO273950   CO276375   CO283959   CO292057   CO292562   CO293089   CO297531   CO298832   CO300721   CO301020   CO303722   CO305364   CO306241   CO313416   CO315092   CO318970   CO322222   CO322381   CO323332   CO323394   CO323459   CO324248   CO325137   CO329254   CO329707   CO331367   CO332497   CO339151   CZ471633   CZ473355   CZ474666   CZ476539   CZ476563   CZ484497   CZ484498   CZ488624   EC057527   EC060445   EC061689   EC063149   EC063706   EC064965   EC071080   EC073859   EC074886   EC078808   EC080182   EC082484   EC087875   EC089857   EC090230   EC199461   EC199983   EC199992   EC200052   EC200563   EC202337   EC203011   EC203936   EC204486   EC205014   EC209952   EC210529   EC211983   EC213656   EC214729   EC228057   EC232547   EC235080   EC235170   EC235575   EC243415   EC243985   EC247646   EC251126   EC257386   EC258028   ES693162   ES693164   EV578137   GH941188   GH941524   GH943381   GH949308   GH951592   GH951810   GH953120   GH953413   GH954283   GH955160   GH958675   GH961360   GH968708   GH969976   GH972897   Z14311 CAA78663   Z14312 CAA78664   Z14974 CAA78696
UniProtKB/Swiss-Prot	Q01617
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Bellen et al., 1992) neuron of chordotonal organ   (Bellen et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Bellen et al., 1992) scolopidial neuron   (Bellen et al., 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Bellen et al., 1992)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Bellen et al., 1992) peripheral nervous system   (Bellen et al., 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval midgut   (Bellen et al., 1992) glial cell   (Bellen et al., 1992) midgut   (Bellen et al., 1992) neuron   (Bellen et al., 1992) embryonic stage 11 -- 16   sensory mother cell   • nucleus (Bellen et al., 1992) embryonic stage 14   sensory organ cell   (Ben-Yaacov et al., 2001) embryonic stage 16   embryonic/larval peripheral nervous system   • nucleus (Bellen et al., 1992)
Additional Descriptive Data
	cpo protein is most abundant in neurons and support cells of the PNS, is less abundant in a number of glia of the PNS and CNS and is present at low levels in the embryonic midgut. cpo protein levels are reduced in a number of unspecified lethal cpo alleles tested. No changes in cpo protein pattern or levels of expression were observed in homozygous viable cpo mutants or in homozygous cpol9 embryos. In da and AS-C- mutants, cpo expression is absent in the PNS except for the chordotonal neurons. Expression in the CNS and midgut is unaffected. (Bellen et al., 1992)
Marker for
	peripheral nervous system
Subcellular Localization
CV Term	nucleus (Bellen et al., 1992)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000363    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000363 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages, in adult male stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000363 expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr  (115) embryo 06-08hr  (655) embryo 08-10hr  (1002) embryo 10-12hr  (783) embryo 12-14hr  (1234) embryo 14-16hr  (2710) embryo 16-18hr  (1943) embryo 18-20hr  (1828) embryo 20-22hr  (950) embryo 22-24hr  (805) larva L1  (931) larva L2  (361) larva L3 12hr old  (209) larva L3 puffstage 1-2    54 larva L3 puffstage 3-6  (172) larva L3 puffstage 7-9  (174) white prepupae new  (205) white prepupae 12hr  (393) white prepupae 24hr  (752) pupae 2d postWPP  (972) pupae 3d postWPP  (674) pupae 4d postWPP  (794) adult male 01day  (816) adult male 05day  (1161) adult male 30day  (1575) adult female 01day  (573) adult female 05day  (211) adult female 30day  (237) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr  (2710) embryo 16-18hr  (1943) embryo 18-20hr  (1828) embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day  (1575) adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000363 expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr  115 embryo 06-08hr  (655) embryo 08-10hr  (1002) embryo 10-12hr  (783) embryo 12-14hr  (1234) embryo 14-16hr  (2710) embryo 16-18hr  (1943) embryo 18-20hr  (1828) embryo 20-22hr  (950) embryo 22-24hr  (805) larva L1  (931) larva L2  (361) larva L3 12hr old  (209) larva L3 puffstage 1-2    54 larva L3 puffstage 3-6  (172) larva L3 puffstage 7-9  (174) white prepupae new  (205) white prepupae 12hr  (393) white prepupae 24hr  (752) pupae 2d postWPP  (972) pupae 3d postWPP  (674) pupae 4d postWPP  (794) adult male 01day  (816) adult male 05day  (1161) adult male 30day  (1575) adult female 01day  (573) adult female 05day  (211) adult female 30day  (237) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr  (2710) embryo 16-18hr  1943 embryo 18-20hr  1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day  1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    45 embryo 04-06hr    115 embryo 06-08hr    655 embryo 08-10hr    1002 embryo 10-12hr    783 embryo 12-14hr    1234 embryo 14-16hr    2710 embryo 16-18hr    1943 embryo 18-20hr    1828 embryo 20-22hr    950 embryo 22-24hr    805 larva L1    931 larva L2    361 larva L3 12hr old    209 larva L3 puffstage 1-2    54 larva L3 puffstage 3-6    172 larva L3 puffstage 7-9    174 white prepupae new    205 white prepupae 12hr    393 white prepupae 24hr    752 pupae 2d postWPP    972 pupae 3d postWPP    674 pupae 4d postWPP    794 adult male 01day    816 adult male 05day    1161 adult male 30day    1575 adult female 01day    573 adult female 05day    211 adult female 30day    237 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000363    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000363 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut, adult heart, larval salivary gland, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CT23539;CG31243-RA;HDC14215 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cpo Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 cpoGD6195 lethal | embryonic stage | recessive cpol1 lethal | larval stage | recessive cpolΔcp11 lethal | recessive cpo1 cpo2 cpo00023 cpo00435 cpo00469 cpo01432 cpo01824 cpo01918 cpo03241 cpo03258 cpo03603 cpo04219 cpo04261 cpo05124 cpo05339 cpo05664 cpo06015 cpo06130 cpo06647 cpo08435 cpoEG1 cpoj4A1 cpoj12B9 cpol2 cpol3 cpol4 cpol5 cpol6 cpol8 cpol9 cpolΔcp11 cpolΔcp12 cporI739 cporJ378 cporJ553 cporK699 cporN217 cporN250 cporO177 cporO320 cporQ383 cpos2336 cpov3 viable cpo1 cpo2 cpoBG01244 cpov1 cpov2 cpov3 viable (with cpo1) cpo2 cpoEG1 cpol2 viable (with cpo2) cpo1 cpoEG1 cpol2 viable (with cpoEG1) cpo1 cpo2 cpov3 viable (with cpol2) cpo1 cpo2 viable (with cpov3) cpoEG1 Other Phenotypes Allele bang sensitive cpounspecified bang sensitive (with cpo1) cpo2 cpoEG1 cpol2 bang sensitive (with cpo2) cpo1 cpoEG1 cpol2 bang sensitive (with cpoEG1) cpo1 cpo2 bang sensitive (with cpol2) cpo1 cpo2 behavior defective cpo1 cpo2 cpov3 behavior defective (with cpo1) cpo2 cpoEG1 cpol1 cpol2 behavior defective (with cpo2) cpo1 cpoEG1 cpol1 cpol2 behavior defective (with cpoEG1) cpo1 cpo2 behavior defective (with cpol1) cpo1 cpo2 behavior defective (with cpol2) cpo1 cpo2 behavior defective | recessive cpo1 cpo2 flight defective cpo1 cpo2 cpov3 flight defective (with cpo1) cpoEG1 cpol1 cpol2 flight defective (with cpo2) cpoEG1 cpol1 cpol2 flight defective (with cpoEG1) cpo1 cpo2 flight defective (with cpol1) cpo1 cpo2 flight defective (with cpol2) cpo1 cpo2 gravitaxis behavior defective cpo1 cpo2 cpov3 gravitaxis behavior defective (with cpo1) cpoEG1 cpol1 cpol2 gravitaxis behavior defective (with cpo2) cpoEG1 cpol1 cpol2 gravitaxis behavior defective (with cpoEG1) cpo1 cpo2 gravitaxis behavior defective (with cpol1) cpo1 cpo2 gravitaxis behavior defective (with cpol2) cpo1 cpo2 hypoactive (with cpo1) cpoEG1 hypoactive (with cpo2) cpoEG1 hypoactive (with cpoEG1) cpo1 cpo2 mating defective (with cpo1) cpoEG1 mating defective (with cpo2) cpoEG1 mating defective (with cpoEG1) cpo1 cpo2 neurophysiology defective (with cpo1) cpoEG1 neurophysiology defective (with cpo2) cpoEG1 neurophysiology defective (with cpoEG1) cpo1 cpo2 phototaxis behavior defective cpo1 cpo2 cpov3 phototaxis behavior defective (with cpo1) cpo2 cpoEG1 cpol1 cpol2 phototaxis behavior defective (with cpo2) cpo1 cpoEG1 cpol1 cpol2 phototaxis behavior defective (with cpoEG1) cpo1 cpo2 phototaxis behavior defective (with cpol1) cpo1 cpo2 phototaxis behavior defective (with cpol2) cpo1 cpo2 smell perception defective cpoBG01244 Phenotype manifest in Allele
Classical Alleles ( 97 )
For All Classical Alleles Show
Allele of cpo Class Mutagen Stocks Known lesion cpo01432 P-element activity 2 -- cpo5-HA-1004 1 -- cpo5-HA-2878 1 -- cpo5-SZ-3162 1 -- cpo5-SZ-3707 1 -- cpoBG02810 P-element activity 1 -- cpod00497 P-element activity 1 -- cpod03424 P-element activity 1 -- cpoDG23101 P-element activity 1 -- cpoe01227 1 -- cpof01629 1 -- cpof02000 piggyBac transposase 1 -- cpof05989 piggyBac transposase 1 -- cpoMI00289 1 -- cpoNP3050 1 -- cpoNP4429 1 -- cpoNP5411 1 -- cpoNP6589 1 -- cpolΔcp11 amorphic allele - genetic evidence P-element activity Delta2-3 0 Yes cpo00014c P-element activity 0 -- cpo00023 P-element activity 0 -- cpo00435 P-element activity 0 -- cpo00469 P-element activity 0 -- cpo01824 P-element activity 0 -- cpo01918 P-element activity 0 -- cpo03241 P-element activity 0 -- cpo03258 P-element activity 0 -- cpo03603 P-element activity 0 -- cpo04219 P-element activity 0 -- cpo04261 P-element activity 0 -- cpo05124 P-element activity 0 -- cpo05339 P-element activity 0 -- cpo05664 P-element activity 0 -- cpo06015 P-element activity 0 Yes cpo06130 P-element activity 0 -- cpo06647 P-element activity 0 -- cpo08435 P-element activity 0 -- cpo1 hypomorphic allele - genetic evidence P-element activity 0 Yes cpo26 0 -- cpo2 hypomorphic allele - genetic evidence P-element activity 0 Yes cpo356Ala natural population 0 Yes cpo356Val natural population 0 Yes cpo462Ile natural population 0 Yes cpo462Lys natural population 0 Yes cpoBG01244 0 Yes cpod05694 P-element activity 0 -- cpod09064 P-element activity 0 -- cpod09096 P-element activity 0 -- cpoEG1 Delta2-3 0 Yes cpoEP2446 0 -- cpoEP2606 0 -- cpoEP3039 P-element activity 0 -- cpoEP3245 P-element activity 0 -- cpoEP3305 0 -- cpoEP3378 P-element activity 0 Yes cpoEP3395 P-element activity 0 -- cpoEP3590 P-element activity 0 -- cpoEP3608 P-element activity 0 -- cpoEP3611 P-element activity 0 -- cpoEP3679 P-element activity 0 -- cpoEP661 P-element activity 0 -- cpof03104 0 -- cpoGS5181 0 Yes cpoGSGB38b3-2 0 Yes cpoGSGB62b2-1 0 Yes cpoHC154B P-element activity 0 -- cpoI462K natural population 0 Yes cpoj12B9 P-element activity 0 -- cpoj4A1 P-element activity 0 Yes cpol1 P-element activity 0 Yes cpol2 P-element activity 0 Yes cpol3 P-element activity 0 Yes cpol4 P-element activity 0 Yes cpol5 P-element activity 0 Yes cpol6 P-element activity 0 Yes cpol8 P-element activity 0 Yes cpol9 hypomorphic allele - genetic evidence P-element activity 0 Yes cpolΔcp12 hypomorphic allele - genetic evidence P-element activity Delta2-3 0 Yes cpoNP5340 0 -- cpoP1.3.03 Delta2-3 0 Yes cpoP3 wild-type allele P-element activity 0 Yes cporB062 P-element activity 0 -- cporI739 P-element activity 0 -- cporJ378 P-element activity 0 -- cporJ553 P-element activity 0 -- cporK699 P-element activity 0 -- cporN217 P-element activity 0 -- cporN250 P-element activity 0 -- cporO177 P-element activity 0 -- cporO320 P-element activity 0 -- cporQ383 P-element activity 0 -- cpos2336 P-element activity 0 -- cpounspecified 0 -- cpov1 P-element activity 0 Yes cpov2 P-element activity 0 Yes cpov3 P-element activity 0 Yes cpoΔ125 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cpo Class Mutagen Stocks Known lesion cpoGD6195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cpoJF02996 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Duplicated in	Dp(3;3)cpo3.20 (Schmidt et al., 2008)
Disrupted in	Df(3R)BSC650 (Christensen et al., 2008.10.20) Df(3R)BSC790 (Christensen et al., 2009.5.6) Df(3R)BX6 (Bellen et al., 1992) Df(3R)cpo3.42 (Schmidt et al., 2008) Df(3R)DG4 (Bellen et al., 1992) Df(3R)gl-BX10 (Bellen et al., 1992) Df(3R)P14 (Spradling et al., 1999, Glasscock, 2005, Bellen et al., 1992, BDGP Project Members, 1994-1999) Df(3R)sr16 (Bellen et al., 1992, Beiman et al., 1996) Df(3R)sr1461 (Bellen et al., 1992)
Not disrupted in	Df(3L)AC1 (BDGP Project Members, 1994-1999) Df(3L)fz-M21 (BDGP Project Members, 1994-1999) Df(3L)h-i22 (BDGP Project Members, 1994-1999) Df(3L)st-f13 (BDGP Project Members, 1994-1999) Df(3L)vin2 (BDGP Project Members, 1994-1999) Df(3L)ZN47 (BDGP Project Members, 1994-1999) Df(3R)by10 (BDGP Project Members, 1994-1999) Df(3R)by62 (BDGP Project Members, 1994-1999) Df(3R)c(3)G-2 (BDGP Project Members, 1994-1999) Df(3R)gl-BX1 (Bellen et al., 1992) Df(3R)XTA1 (BDGP Project Members, 1994-1999) Tp(3;2)by62 (BDGP Project Members, 1994-1999) Tp(3;Y)L58 (Glasscock, 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6195} NA P{TRiP.JF02996} NA reporter construct P{lacZcpo.P} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{HomingPigeon.FRT}cpoHC154B No P{lacW}cpoj4A1 No P{lacW}cpoj12B9 No P{lacW}cpol3 No P{lacW}cpol5 No P{lacW}cpol8 No P{lacW}cpol9 No P{lacW}cpos2336 No P{lacW}l(3)SH002SH002 No P{lacZ}cpoEG1 No P{lacZ}cpol1 No P{lacZ}cpol2 No P{lacZ}cpol4 No P{lacZ}cpol6 No P{lacZ}cpolΔcp11 No P{lacZ}cpolΔcp12 No P{lacZ}cpov1 No P{lacZ}cpov2 No P{lacZ}cpov3 No P{lArB}A293.1M3 No P{lArB}cpo1 No P{lArB}cpo2 No P{PZ}cpo00014c No P{PZ}cpo00023 No P{PZ}cpo00435 No P{PZ}cpo00469 No P{PZ}cpo01432 No P{PZ}cpo01824 No P{PZ}cpo01918 No P{PZ}cpo03241 No P{PZ}cpo03258 No P{PZ}cpo03603 No P{PZ}cpo04219 No P{PZ}cpo04261 No P{PZ}cpo05124 No P{PZ}cpo05339 No P{PZ}cpo05664 No P{PZ}cpo06015 No P{PZ}cpo06130 No P{PZ}cpo06647 No P{PZ}cpo08435 No P{PZ}cporB062 No P{PZ}cporI739 No P{PZ}cporJ378 No P{PZ}cporJ553 No P{PZ}cporK699 No P{PZ}cporN217 No P{PZ}cporN250 No P{PZ}cporO177 No P{PZ}cporO320 No P{PZ}cporQ383 No miscellaneous insertions Mi{MIC}cpoMI00289 NA P{GT1}cpoBG01244 NA P{GT1}cpoBG02810 NA P{PT1}cpo26 NA P{RS5}cpo5-HA-1004 NA P{RS5}cpo5-HA-2878 NA P{RS5}cpo5-SZ-3162 NA P{RS5}cpo5-SZ-3707 NA P{Switch2}cpoGSGB38b3-2 NA P{Switch2}cpoGSGB62b2-1 NA P{wHy}cpoDG23101 NA P{wHy}DG05201 NA PBac{RB}cpoe01227 NA PBac{WH}cpof01629 NA PBac{WH}cpof02000 NA PBac{WH}cpof03104 NA PBac{WH}cpof05989 NA insertion of mobile activating element P{EP}cpoEP661 NA P{EP}cpoEP2446 NA P{EP}cpoEP2606 NA P{EP}cpoEP3039 NA P{EP}cpoEP3245 NA P{EP}cpoEP3305 NA P{EP}cpoEP3378 NA P{EP}cpoEP3395 NA P{EP}cpoEP3590 NA P{EP}cpoEP3608 NA P{EP}cpoEP3611 NA P{EP}cpoEP3679 NA P{GSV1}GSd322GSd322 NA P{GSV1}GSd425GSd425 NA P{GSV1}GSd464b NA P{GSV2}cpoGS5181 NA P{Mae-UAS.6.11}B0751B0751 NA P{Mae-UAS.6.11}cpoP1.3.03 NA P{XP}cpod00497 NA P{XP}cpod03424 NA P{XP}cpod05694 NA P{XP}cpod09064 NA P{XP}cpod09096 NA insertion of enhancer trap binary system P{GawB}cpoNP3050 No P{GawB}cpoNP4429 No P{GawB}cpoNP5340 No P{GawB}cpoNP5411 No P{GawB}cpoNP6589 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Boutros et al., 2004) dormancy process inferred from mutant phenotype (Schmidt et al., 2008) olfactory behavior inferred from mutant phenotype (Sambandan et al., 2006) synaptic transmission inferred from mutant phenotype (Glasscock, 2005)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Bellen et al., 1992)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Bellen et al., 1992, Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
peripheral nervous system development non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2008) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cpo allele Gene References cpo1 sda (Glasscock, 2005) cpoEG1 sda (Zhang et al., 2002) cpol2 sda (Glasscock, 2005) unspecified eas (Glasscock, 2005) Nsf2 (Laviolette et al., 2005) os (Mukherjee et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69919 DroID - A comprehensive database of gene and protein interactions. • FBgn0000363 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45840
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16747 Dere\GG22582 Dgri\GH15012 Dmoj\GI23706 Dper\GL12579 Dpse\GA16117 Dsec\GM15269 Dsim\GD19192 Dvir\GJ23264 Dyak\GE25503
Curated drosophilid orthologs	Dmon\cpo (Kankare et al., 2010) Dpse\GA16117
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • XP_001952194.1 Acyrthosiphon pisum (pea aphid) At3g21215.1 Arabidopsis thaliana (wall cress) cn12312 Cryptococcus neoformans (yeast-like fungus) KLLA0F20834g Kluyveromyces lactis (yeast) XP_001605039.1 Nasonia vitripennis (wasp) 655110 Populus trichocarpa (black cottonwood) 5058600 Sorghum bicolor (sorghum) YNL197C Saccharomyces cerevisiae (budding yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0248926
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	28360 y1 v1; P{TRiP.JF02996}attP2
Harvard	- P{XP}cpod00497 - P{XP}cpod03424 - PBac{RB}cpoe01227 - PBac{WH}cpof01629 - PBac{WH}cpof02000 - PBac{WH}cpof05989
Kyoto	125002 w1118; P{RS5}cpo5-HA-1004 125723 w1118; P{RS5}cpo5-HA-2878 125926 w1118; P{RS5}cpo5-SZ-3162 126194 w1118; P{RS5}cpo5-SZ-3707
VDRC	v14385 w1118; P{GD6195}v14385
	More stocks available...
Genomic Clones ( 3 )
	BACR01C15 BACR35E22 BACR45M04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT31405 RE20544 RE30936
Other clones	MIP15437
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21223 HL02466 HL03492 RE31090 RE38152 RE42256 RE49249 RE51149 RE53579 RE59922 RE60022 RE71174 RE75070 RH33913 RH35943 RH52415
Other clones	10245 11911 13229 16710 37712 38054 42667 53151 54360 54479 55309 62471 63565 63672 63679 64793 67530 71753 72855 80984 102614 102888 103692 104225 119316 145939 159655 174400 190225 190949 193642 214221.3 214503.58 272779 276571 CK01.15A.H12 CK01.31A.C7 CK01.119C.B12 CK01.119D.E1 CK01.146D.E10 Dmel_dig_008839_0598_0632 EK006307 EK026912 EK042307 EK091238 EK091317 EK110116 EK112718 EK120649 EK150119 EK164912 EK170024 EK173940 EK179251 EK179916 EK187602 EK188023 EK190229 EK190361 EK190521 EK193049 EK195657 EK199105 EK200447 EK201660 EK232905 EK239012 EK242626 EK248333 EK250608 EK275650 EK292347 EK293547 EK299415 EK303647 EP00955 RP004027111 RP004102752 RP004116719 RP004130639 RP004134861 RP004154088 RP004156518 RP004188117 RP004251380 RP004266460 RP004269541 RP004391467 RP004433865 RP004451617 RP004535805
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45840
Antibody Information
	polyclonal (Bellen et al., 1992, Bellen et al., 1992, Bellen et al., 1992)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cpo BcDNA:AT31405 (FlyBase, 1996-) Source for merge of: cpo CG12349 CG18435 (FlyBase Genome Annotators, 2002-2003) Source for merge of: cpo CG18434 (Bayraktaroglu, 2000.4.13) Source for merge of: cpo E(sda)N (Glasscock, 2005)
Additional comments	One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG31243 (FBgn0000363), CG42457 (FBgn0259934). (FlyBase Genome Annotators, 2008) Annotations CG12349, CG18434 and CG18435 merged as CG31243 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of cpo BcDNA:AT31405 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Candidate gene for quantitative trait (QTL) locus determining bristle number. (Nuzhdin et al., 1999) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Mutant cpo individuals exhibit an abnormal and hypoactive behaviour. (Bellen et al., 1992) The cpo gene encodes a nuclear protein, and achaete, scute and daughterless gene function are required for proper expression of cpo in the PNS. (Bellen et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080105 NM_169782 NM_169783 NM_001170169 RefSeq (Proteins) • NP_524844 NP_732283 NP_732284 NP_001163640 DDBJ / EMBL / GenBank • AAF55483 AAF55483.3 AAF55483.4 AAF55484 AAF55484.3 AAF55484.4 AAF55485 AAF55485.3 AAF55485.4 AAM76197 AAN13754 AAN13754.2 AAN13754.3 AAN71324 AAX52960 AAX52961 ACZ94936 AF006652 AQ073308 AQ073957 AY118720 AY129455 BG634976 BI214589 BI235126 BT001569 CAA78663 CAA78664 CAA78696 CZ471633 CZ473355 CZ474666 CZ476539 CZ476563 CZ484497 CZ484498 CZ488624 Z14311 Z14312 Z14974 Entrez Gene - A searchable database of RefSeq genes. • 45840 UniProtKB/Swiss-Prot • Q01617
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69919 DroID - A comprehensive database of gene and protein interactions. • FBgn0000363 DRSC - Results from RNAi screens. • FBgn0000363 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000363 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CT23539;CG31243-RA;HDC14215 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000363 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45840 InParanoid A subset of ortholog calls from InParanoid. • XP_001952194.1 Acyrthosiphon pisum (pea aphid) At3g21215.1 Arabidopsis thaliana (wall cress) cn12312 Cryptococcus neoformans (yeast-like fungus) KLLA0F20834g Kluyveromyces lactis (yeast) XP_001605039.1 Nasonia vitripennis (wasp) 655110 Populus trichocarpa (black cottonwood) 5058600 Sorghum bicolor (sorghum) YNL197C Saccharomyces cerevisiae (budding yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45840 modMine - Data generated by the modENCODE project. • FBgn0000363 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0248926
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	1824 (Harvie et al., 1998) 3603 (Harvie et al., 1998) 5339 (Harvie et al., 1998) 6015 (Harvie et al., 1998) BcDNA:AT31405   CG12349 (Boutros et al., 2004, Evans et al., 2002, ) CG18434   CG18435 (Boutros et al., 2004, Evans et al., 2002, ) cg18435 (Lasko, 2000) CG31243 (Metaxakis et al., 2005, Laviolette et al., 2005, Grieder et al., 2007, Perkins et al., 2009, Maia et al., 2007) cpo (Edwards et al., 2006, Turner et al., 2008, Reeves and Posakony, 2005, Laviolette et al., 2005, Stark et al., 2005, Mukherjee et al., 2006, Bolinger and Boekhoff-Falk, 2005, Reiter et al., 2007, Nicholson et al., 2008, Larsen et al., 2006, Maines et al., 2007, Liebl et al., 2006, Arancio et al., 2010, Larsen et al., 2006, Schmidt et al., 2008, Grieder et al., 2007, FlyBase Genome Annotators, 2008, Minidorff et al., 2007, Christensen et al., 2008.10.20, Raymond et al., 2004, Leandro et al., 2007, Christensen et al., 2009.5.6, Ruedi and Hughes, 2009, Schmidt et al., 2008, Branco et al., 2008, Dubruille et al., 2009, Glazov et al., 2005, Firth and Baker, 2007, Maia et al., 2007, Lee et al., 2011, Reis et al., 2010) Cpo (Bender and Hudson, 2000, Goulding et al., 2000, Jattani et al., 2009, zur Lage and Jarman, 2010) CPO (O'Farrell and Kylsten, 2008) E(sda)N   l(3)01432   l(3)6015 (Harvie, 1997.6.4) l(3)j4A1   l(3)j4D4   l(3)j7E2   l(3)j9B3   l(3)rJ553   l(3)s2336   Line N (Zhang et al., 2002) ORE-17 (Maia et al., 2007) unnamed (Treisman and Rubin, 1996)
Name Synonym	couch potato (Edwards et al., 2006, Sambandan et al., 2006, Bolinger and Boekhoff-Falk, 2005, Nicholson et al., 2008, Schmidt et al., 2008, Raymond et al., 2004, Ruedi and Hughes, 2009, Schmidt et al., 2008, Glazov et al., 2005, Lee et al., 2011) Couch potato (Jattani et al., 2009)
Secondary FlyBase IDs
	FBgn0011025 FBgn0011358 FBgn0011368 FBgn0011405 FBgn0011416 FBgn0011503 FBgn0038560 FBgn0038561 FBgn0038562 FBgn0051243 FBgn0063288 FBgn0066121
References ( 120 )
Generate a list of	All references relating to this gene ( 120 )
List References by type	Research paper  ( 73 ) Supplementary material  ( 8 ) Review  ( 6 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 9 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 )
Recent research papers ( 5 )
	Lee et al., 2011, Mol. Ecol. 20(14): 2973--2984 Polymorphism in the couch potato gene clines in eastern Australia but is not associated with ovarian dormancy in Drosophila melanogaster. [FBrf0214238] Arancio et al., 2010, Genetics 185(1): 129--140 The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. [FBrf0213976] Kankare et al., 2010, BMC Ecol. 10(1): 3 Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study. [FBrf0210028] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] zur Lage and Jarman, 2010, BMC Dev. Biol. 10: 34 The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. [FBrf0210540] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...