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Gene Dmel\crm

General Information
Symbol	Dmel\crm	Species	D. melanogaster
Name	cramped	Annotation symbol	CG2714
Feature type	protein_coding_gene	FlyBase ID	FBgn0000376
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	zw9, l(1)zw9, zw-9, sa, EG:95B7.2
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.48
Cytogenetic map	3B3-3B4	Sequence location	X:2,628,277..2,632,810 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cramped is referred to in FlyBase by the symbol Dmel\crm (CG2714, FBgn0000376). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: segment specification. 35 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; antennal segment; appendage segment; somatic cell; external compound sense organ; adult mesothoracic segment; thoracic segment; organ system; prothoracic leg; compound cell cluster organ; pigment cell; metatarsus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: SANT domain, DNA binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1641644_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of crm. Gene sequence location is X:2628277..2632810.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	*crm: cramped Antennae swollen, aristae short, and branches fewer than in wild type. Wings slightly divergent and in some alleles nicked. Males have small extra sex combs on second tarsal segment of prothoracic legs and less frequently on basitarsal segments of mesothoracic and rarely metathoracic legs. crmsa;Pc/+ males have large sex combs on all six basitarsi and small sex combs on all second tarsal segments in many flies. One or both postverticals lacking and other bristles occasionally missing or doubled. Body slightly darkened. Fertility of both males and females reduced, females more severely than males. Strength of sterilizing effect allele dependent. Females generally sterile; surviving crml females have rudimentary ovaries with no oocytes beyond stage 7 (Shannon, Kaufman, Shen, and Judd, 1972, DIS 48: 92); males of crm2 and crm7 partially fertile, other alleles male sterile. Viability variably reduced depending on crowding in culture; crm4, crm7 are semilethal alleles, crm6 die in late third instar; survivors eclose on days 11-13; rarely survive in combination with a deficiency (Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; Shannon et al., 1972).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Gibert et al., 2011, PLoS Genet. 7(1): e1001280 FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Sequence features BKN27246 HFA18754 Controlled Vocabulary Terms chromatin binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3B3-3B4   Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3C1-3C1     (Girard, 1997.6.6)
Experimentally Determined Recombination Data
Location	1-1.48   1-1.1 (Bateman, 1951) 1-1.4 +/- 0.1 (Fahmy and Fahmy, 1958) 1-1.3 +/- 0.5 (Fahmy and Fahmy, 1959)
Left of (cM)	w (Rayle and Green, 1968, Judd et al., 1972, Sorsa et al., 1973)
Right of (cM)	dwg (Judd et al., 1972) l(1)3Bf (Rayle and Green, 1968)
Notes	Mapping based on crmsa with w.   No crossing over with w in 254 flies. (Bateman, 1951)
Gene Model & Products
Please see the GBrowse view of Dmel\crm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) crm-RA FBtr0070496  NM_057757   3784   982 crm-RB FBtr0070495  NM_166951   3845   982
Additional Transcript Data & Comments
Reported size (kB)	3.793 (longest cDNA) (Yamamoto et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein crm-PA   FBpp0070473   107.4   982   8.23     NP_477105   AAG22402 crm-PB   FBpp0070472   107.4   982   8.23     NP_726829   AAF45822
Additional Polypeptide Data & Comments
Reported size (kDa)	693 (aa); 110 (kD observed); 75 (kD predicted) (Yamamoto et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201164   AA201573   AA202684   AA390394   AA439550   AA538880   AA539351   AA539403   AA539675   AA540467   AA735279   AA816983   AA942050   AA949467   AA949603   AA950297   AE014298 AAF45822   AE014298 AAG22402   AF365364 AAN04260   AF365365 AAN04261   AF365366 AAN04262   AF365367 AAN04263   AF365368 AAN04264   AF365369 AAN04265   AF365370 AAN04266   AF365371 AAN04267   AF365372 AAN04268   AF365373 AAN04269   AF365374 AAN04270   AF365375 AAN04271   AF365376 AAN04272   AF365377 AAN04273   AF365378 AAN04274   AF365379 AAN04275   AF365380 AAN04276   AF365381 AAN04277   AF365382 AAN04278   AF365383 AAN04279   AF365384 AAN04280   AF365385 AAN04281   AF365386 AAN04282   AF365387 AAN04283   AF365388 AAN04284   AF365389 AAN04285   AF365390 AAN04286   AF365391 AAN04287   AF365392 AAN04288   AF365393 AAN04289   AF365394 AAN04290   AF365396 AAN04291   AF365397 AAN04292   AF365398 AAN04293   AI238609   AI456049   AI511769   AI515428   AI518844   AI534412   AJ569035   AJ569036   AJ569037   AJ569038   AJ569039   AJ569040   AJ569041   AJ569042   AJ569043   AJ569044   AJ569045   AJ569046   AJ569047   AJ569048   AJ569049   AJ569050   AJ569051   AJ569052   AJ569053   AJ569054   AJ569055   AJ569056   AJ569057   AJ569058   AL021728 CAA16818   AW942970   AY051767 AAK93191   BG637759   BI169023   BI229344   BI234483   BI366963   BI487158   BI583178   CL527800   CO265439   CO266725   CO310319   CZ483823   EC073325   EC077225   EC199088   EC213404   EC244638   EL870137   EL870138   EL870139   EL870140   Y13674 CAB55550
UniProtKB/Swiss-Prot	O76906
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Yamamoto et al., 1997) embryonic stage   presumptive embryonic/larval nervous system   (Yamamoto et al., 1997) gonad   (Yamamoto et al., 1997) pole cell   (Yamamoto et al., 1997) third instar larval stage   embryonic/larval salivary gland   (Yamamoto et al., 1997)
Additional Descriptive Data
	crm protein localization is cell-cycle dependent. crm protein localizes to the nucleus during S phase and disappears at mitosis. (Yamamoto et al., 1997)
Marker for
Subcellular Localization
CV Term	nucleus (Yamamoto et al., 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0000376    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0000376 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0000376 expression level Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7485) embryo 02-04hr  (4767) embryo 04-06hr  (2615) embryo 06-08hr  (2588) embryo 08-10hr  (2759) embryo 10-12hr  (1910) embryo 12-14hr  (1492) embryo 14-16hr  (2105) embryo 16-18hr  (1554) embryo 18-20hr  (969) embryo 20-22hr  (1459) embryo 22-24hr  (1484) larva L1  (427) larva L2  (262) larva L3 12hr old  (221) larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (532) larva L3 puffstage 7-9  (501) white prepupae new  (463) white prepupae 12hr  (620) white prepupae 24hr  (744) pupae 2d postWPP  (449) pupae 3d postWPP  (222) pupae 4d postWPP  (273) adult male 01day  (293) adult male 05day  (416) adult male 30day  (475) adult female 01day  (2016) adult female 05day  (3674) adult female 30day  (4174) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7485) embryo 02-04hr  (4767) embryo 04-06hr  (2615) embryo 06-08hr  (2588) embryo 08-10hr  (2759) embryo 10-12hr  (1910) embryo 12-14hr  1492 embryo 14-16hr  (2105) embryo 16-18hr  (1554) embryo 18-20hr    969 embryo 20-22hr  1459 embryo 22-24hr  1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day  (2016) adult female 05day  (3674) adult female 30day  (4174) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0000376 expression level Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7485) embryo 02-04hr  (4767) embryo 04-06hr  (2615) embryo 06-08hr  (2588) embryo 08-10hr  (2759) embryo 10-12hr  (1910) embryo 12-14hr  (1492) embryo 14-16hr  (2105) embryo 16-18hr  (1554) embryo 18-20hr  (969) embryo 20-22hr  (1459) embryo 22-24hr  (1484) larva L1  (427) larva L2  (262) larva L3 12hr old  (221) larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (532) larva L3 puffstage 7-9  (501) white prepupae new  (463) white prepupae 12hr  (620) white prepupae 24hr  (744) pupae 2d postWPP  (449) pupae 3d postWPP  (222) pupae 4d postWPP  (273) adult male 01day  (293) adult male 05day  (416) adult male 30day  (475) adult female 01day  (2016) adult female 05day  (3674) adult female 30day  (4174) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7485) embryo 02-04hr  (4767) embryo 04-06hr  (2615) embryo 06-08hr  (2588) embryo 08-10hr  (2759) embryo 10-12hr  1910 embryo 12-14hr  1492 embryo 14-16hr  2105 embryo 16-18hr  1554 embryo 18-20hr    969 embryo 20-22hr  1459 embryo 22-24hr  1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day  2016 adult female 05day  (3674) adult female 30day  (4174) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7485 embryo 02-04hr    4767 embryo 04-06hr    2615 embryo 06-08hr    2588 embryo 08-10hr    2759 embryo 10-12hr    1910 embryo 12-14hr    1492 embryo 14-16hr    2105 embryo 16-18hr    1554 embryo 18-20hr    969 embryo 20-22hr    1459 embryo 22-24hr    1484 larva L1    427 larva L2    262 larva L3 12hr old    221 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    532 larva L3 puffstage 7-9    501 white prepupae new    463 white prepupae 12hr    620 white prepupae 24hr    744 pupae 2d postWPP    449 pupae 3d postWPP    222 pupae 4d postWPP    273 adult male 01day    293 adult male 05day    416 adult male 30day    475 adult female 01day    2016 adult female 05day    3674 adult female 30day    4174 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0000376    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0000376 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0000376 expression level Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0000376 expression level Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    110.025 Larval Midgut    47.7 Larval Hindgut    53 Larval Malpighian Tubules    34 Larval Fat Body    33.8 Larval Salivary Gland    57.4 Larval Trachea    50.125 Larval Carcass    51.275 Adult Head    61 Adult Eye    31.475 Adult Brain    112.1 Adult Thoracic-Abdominal Ganglion    89.2 Adult Crop    61.9 Adult Midgut    40 Adult Hindgut    52.6 Adult Malpighian Tubules no informative data Adult Fat Body    47.8 Adult Salivary Gland    68.6 Adult Heart    14.125 Adult VirginFemale Spermatheca    29.3 Adult InseminatedFemale Spermatheca    32.3 Adult Ovary    350.8 Adult Testis no informative data Adult Male Accessory Gland    62.8 Adult Carcass    64.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    61   NA  Eye    31.475   NA  Brain    112.1   110.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89.2   NA  Crop    61.9   47.7  Midgut    40   53  Hindgut    52.6   34  Malpighian Tubules    no informative data   33.8  Fat Body    47.8   57.4  Salivary Gland    68.6   NA  Heart    14.125   50.125  Trachea    NA   NA  VirginFemale Spermatheca    29.3   NA  InseminatedFemale Spermatheca    32.3   NA  Ovary    350.8   NA  Testis    no informative data   NA  Male Accessory Gland    62.8   51.275  Carcass    64.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000376 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2714-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone crm7 lethal | larval stage | recessive crm6 crm7 lethal | maternal effect | polyphasic crm9 lethal | pupal stage | recessive crmsa2 crmsa lethal | recessive crm7 crm8 crme51 crmm25 crmM37 crmm45 semi-lethal crm1 crm4 crm7 crmm55 viable crmEY05302 viable, with Scer\GAL4pnr-MD237 crmGD1409 viable | female | poor crm2 viable | male | poor crmswa viable | male | reduced crm2 Sterility Allele female fertile | partially crm2 female fertile | poor crm2 female sterile crm1 crm5 crm7 crmsa2 crmsa crmswa fertile crmEY05302 male fertile crmswa male fertile | partially crm2 male fertile | reduced crm2 male sterile crm1 crm3 crm4 crmsa2 crmsa sterile crm1 Other Phenotypes Allele body color defective crmswa eye color defective crmswa suppressor of variegation | dominant, with In(1)wm4h crmsa visible crm1 crm5 crm7 crmsa2 crmsa crmswa visible | recessive crm2 wild-type crm+t14 Phenotype manifest in Allele antenna crm1 crm2 crm7 crmsa crmsa2 crmswa arista crm1 crm2 crm5 crm7 crmsa crmsa2 crmswa eye crm1 crm2 crmswa leg crmswa mesothoracic leg crm7 metathoracic leg crm7 ovariole | germline clone crm9 ovary crm1 crm5 crm7 pigment cell crmsa crmswa postvertical bristle crmsa crmsa2 prothoracic leg crm7 prothoracic tarsal segment 2 crmswa sex comb crm2 crm5 crm7 crmswa sex comb & mesothoracic tarsal segment 2 crmsa crmsa2 sex comb & prothoracic tarsal segment 2 crmsa crmsa2 sex comb | ectopic crm7 tarsal segment 2 crm2 third segment of antenna crm5 crm7 wing crm1 crm2 crmsa crmsa2 crmswa
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of crm Class Mutagen Stocks Known lesion crm7 X ray 2 -- crmEY05302 P-element activity 1 -- crmf01351 piggyBac transposase 1 -- crmsa2 spontaneous 1 -- crm10 ethyl methanesulfonate 2-chloroethyl methanesulfonate 0 -- crm11 2-chloroethyl methanesulfonate 0 -- crm12 p-N,N-di-(2-chloroethyl)aminophenylethylamine 0 -- crm13 p-N,N-di-(2-chloroethyl)amino-L-phenylalanine 0 -- crm14 p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine 0 -- crm15 S-2-chloroethylcysteine 0 -- crm16 methyl methanesulfonate 0 -- crm1 32P 0 -- crm2 p-N,N-di-(2-chloroethyl)amino-L-phenylalanine 0 -- crm3 X ray 0 -- crm4 X ray 0 -- crm5 X ray 0 -- crm6 X ray 0 -- crm8 spontaneous 0 -- crm9 ethyl methanesulfonate 0 -- crme51 ethyl methanesulfonate 0 -- crmGG01400 0 -- crmm25 methyl methanesulfonate 0 -- crmM37 methyl methanesulfonate 0 -- crmm45 methyl methanesulfonate 0 -- crmm55 methyl methanesulfonate 0 -- crmNKu1 urethane 0 -- crmsa spontaneous 0 -- crmswa2 ethyl methanesulfonate 0 -- crmswa 2-chloroethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of crm Class Mutagen Stocks Known lesion crmGD1409 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crmGL00306 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crmJF01296 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crmKK107246 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes crm+t14 in vitro construct - genomic fragment 0 Yes crmrescue- in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)62d18 (Judd et al., 1972) Df(1)64c4 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)202 (Nomura and Kurokawa, 1997) Df(1)HM3 (Kramers et al., 1983) Df(1)HM406 (Kramers et al., 1983) Df(1)LCD (Yamamoto et al., 2000) Df(1)N-8 (Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)TEM75 (Lim and Snyder, 1974) Df(1)TEM202 (Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM501 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)w68a (Sorsa et al., 1973) Df(1)w70j (Sorsa et al., 1973) Df(1)w70k (Sorsa et al., 1973) Df(1)w71b (Sorsa et al., 1973) Df(1)w-72C2 (Pastink et al., 1987) Df(1)w258-11 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-42 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-45 (Rayle and Green, 1968, Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)w258-48 (Kramers et al., 1983, Kramers et al., 1991) Df(1)w-DZL-1 (Bingham, 1981) Df(1)w-DZL-3 (Bingham, 1981) Df(1)w-N71a (Judd et al., 1972) Df(1)w-rJ1 (Judd et al., 1972, Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Nomura and Kurokawa, 1997) Df(1)w-rJ2 (Judd et al., 1972) Df(1)z-deb65 (Goldberg et al., 1989) Df(1)z-deb72 (Goldberg et al., 1989) In(1)w-70L26.3 (Sorsa et al., 1973)
Duplicated in	Dp(1;2;Y)w+ (Judd et al., 1972, Kramers et al., 1983, Kramers et al., 1991) Dp(1;2)w+70h (Judd et al., 1972) Dp(1;3)N264-58 (Judd et al., 1972) Dp(1;3)w+67k (Judd et al., 1972) Dp(1;3)wm49a (Judd et al., 1972) Dp(1;3)wm76 (Green, 2005.9.1) Dp(1;3)wvco (Rayle and Green, 1968) Dp(1;4)wm65g (Judd et al., 1972) Dp(1;Y)y267g19.1 (Lefevre, 1981)
Not disrupted in	Df(1)7 (Nomura and Kurokawa, 1997) Df(1)62g18 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)64f1 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)64j4 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)65j26 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)304 (Nomura and Kurokawa, 1997) Df(1)K95 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)L126 (Nomura and Kurokawa, 1997) Df(1)N-8 (Kramers et al., 1983) Df(1)N-54l9 (Kramers et al., 1991) Df(1)N-264-105 (Kramers et al., 1991) Df(1)Pgd-kz (Kramers et al., 1991) Df(1)Sp2F-3A (Schalet, 1986) Df(1)TEM1 (Lim and Snyder, 1974, Kramers et al., 1991) Df(1)TEM6 (Lim and Snyder, 1974) Df(1)TEM7 (Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM304 (Lim and Snyder, 1974, Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)w55j (Lin and Wolfner, 1989) Df(1)w67k30 (Kramers et al., 1983, Kramers et al., 1991) Df(1)w70e (Sorsa et al., 1973) Df(1)w-DZL-2 (Bingham, 1981) Df(1)w-DZL-14 (Bingham, 1981) Df(1)w-EM22 (Montgomery et al., 1991) Df(1)X12 (Judd et al., 1972, Thierry-Mieg, 1982, Yamamoto et al., 1997) Df(1)X22 (Yamamoto et al., 1997) Df(1)z-deb3 (Goldberg et al., 1989) Df(1)z-deb42 (Goldberg et al., 1989) Df(1)z-deb54 (Goldberg et al., 1989) Df(1)z-deb59 (Goldberg et al., 1989) Df(1)z-deb62 (Goldberg et al., 1989) Df(1)z-deb81 (Goldberg et al., 1989) Df(1)z-deb85 (Goldberg et al., 1989) Df(1)z-deb87 (Goldberg et al., 1989) Df(1)z-deb92 (Goldberg et al., 1989) Df(1)z-deb311 (Goldberg et al., 1989) Df(1)z-deb511 (Goldberg et al., 1989) Df(1)z-deb910 (Goldberg et al., 1989)
Not duplicated in	Dp(1;2)51b (Kramers et al., 1983, Kramers et al., 1991) Dp(1;3)wvco (Schalet, 1986) Tp(1;2)w+1 (Green, 1984) Tp(1;2)w+4 (Green, 1984) Tp(1;2)w+5 (Green, 1984) Tp(1;2)w+6 (Green, 1984) Tp(1;3)w+2 (Green, 1984) Tp(1;3)w+3 (Green, 1984) Tp(1;3)w+7 (Green, 1984)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1409} NA P{KK107246} NA P{TRiP.GL00306} NA P{TRiP.JF01296} NA characterization construct P{crm.rescue-} NA P{crm.rescue+} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}crmEY05302 NA P{Mae-UAS.6.11}crmGG01400 NA miscellaneous insertions PBac{WH}crmf01351 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Yamamoto et al., 1997)
Biological Process
CV term Evidence References
segment specification inferred from mutant phenotype (assigned by UniProtKB) (Yamamoto et al., 1997)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Yamamoto et al., 1997)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001005 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA replication non-traceable author statement (Harr, 2001.3.24) regulation of transcription, DNA-dependent non-traceable author statement (assigned by UniProtKB) (Yamamoto et al., 1997)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions crm allele Gene References crm7 mus209 (Yamamoto et al., 1997) Pc (Yamamoto et al., 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57799 DroID - A comprehensive database of gene and protein interactions. • FBgn0000376 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31268
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22481 Dere\GG18607 Dgri\GH12275 Dmoj\GI10971 Dper\GL19806 Dpse\GA15444 Dsec\crm Dsim\crm Dvir\GJ18529 Dwil\GK25402 Dyak\GE16922
Curated drosophilid orthologs	Dpse\GA15444   Dsec\crm   Dsim\crm (Harr and Schlotterer, 2000)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014683-PA Aedes aegypti (mosquito) AGAP001029-PA Anopheles gambiae (mosquito) XP_001952351.1 Acyrthosiphon pisum (pea aphid) XP_001902870.1 Brugia malayi (roundworm nematode) BGIBMGA014363-PA Bombyx mori (silk worm) JA14183 Caenorhabditis japonica (nematode) CPIJ014021 Culex pipens (mosquito) RP39654 Caenorhabditis remanei (nematode) 206971 Capitella spl (polychaete worm) 326754 Daphnia pulex (daphnia) ENSECAP00000020840 Equus caballus (horse) ENSGACP00000017201 Gymnopilus aculeatus (mushroom) ENSGALP00000015195 Gallus gallus (chicken) 194326 Hypsipyla robusta (cedar shoot borer) ENSP00000380559 Homo sapiens (human) ISCW017333-PA Ixodes scapularis (deer tick) ENSMUSP00000073060 Mus musculus (house mouse) 243801 Nematostella vectensis (starlet anemone) XP_001605790.1 Nasonia vitripennis (wasp) ENSORLP00000014518 Oryzias latipes (japanese killifish) PHUM006811-PA Pediculus humanus (human body louse) ENSPPYP00000007878 Pongo pygmaeus (orangutan) ENSPTRP00000053805 Pan troglodytes (chimpanzee) ENSRNOP00000022050 Rattus norvegicus (norway rat) Smp_168340 Schistosoma mansoni (trematode parasite) 56673 Trichoplax adhaerens (metazoa) XP_973783.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005216 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008606 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043640 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17764 NV15647 LH20377 ISCW017333 FBgn0234411 FBgn0227361 FBgn0205687 FBgn0041270 FBgn0063998 JGI_V11_326754 FBgn0075461 FBgn0157404 FBgn0133734 FBgn0110818 FBgn0099477 CPIJ014021 BGIBMGA014363 ACYPI000215 GB30217 GB16357 GB15282 AGAP001029 AAEL014683 PHUM117620 GLEAN_07439
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	16650 y1 P{EPgy2}crmEY05302 w67c23 35387 y1 sc* v1; P{TRiP.GL00306}attP2 9144 y1 crmsa2 sn3; Dp(1;3)wm76 31338 y1 v1; P{TRiP.JF01296}attP2/TM3, Ser1 4281 crm7 Nspl-1 sn3/FM7a/Dp(1;2;Y)w+
Harvard	- PBac{WH}crmf01351
Kyoto	107666 crm7, Nspl-1 sn3/FM7a/Dp(1;2;Y)w+
VDRC	v100245 P{KK107246}VIE-260B v6308 w1118; P{GD1409}v6308
Genomic Clones ( 1 )
	BACR30B01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 38 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29481
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14686 LD03078 LD03870 LD04645 LD09365 LD14149 LD17443 LD17507 LD17960 LD18522 LD19964 LD21932 LD26061 LD28810 LD29561 LD35249 LD35873 LD43284 LD47257 RE09979 RE27109 RE30186 RE52618 RE70672 RH21714 SD07223
Other clones	31987 36509 40436 98267 125301 EK142655 EK147342 EK221220 IP02241 IP02242 LD02882
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0000376 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31268
Antibody Information
	polyclonal (Yamamoto et al., 1997)
Other Information
Discoverer
	Bateman.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: crm CG2714 (Deng, 1999.11)
Source for database merge of
Additional comments	l(1)zw9, sa: sparse arista and swa: swollen antennae. These are now designated alleles of crm.
Other Comments
	Mutants exhibit typical Pc-group phenotypes, including homeotic transformations and modification of PEV. (Yamamoto et al., 1997) A member of the Pc group. The genetic interaction between crm and mus209 highlight possible interactions between Pc-group mediated gene silencing and DNA replication. (Yamamoto et al., 1997) crm is allelic with 'sa'. (Judd et al., 1972) l(1)zw9 is synonymous with sa. (Shannon et al., 1972) Antennae swollen, aristae short and branches fewer than in wild type. Wings slightly divergent and in some alleles nicked. Males have small extra sex combs on second tarsal segment of prothoracic legs and less frequently on basitarsal segments of mesothoracic and rarely metathoracic legs. crmsa;Pc/+ males have large sex combs on all six basitarsi and small sex combs on all second tarsal segments in many flies. One or both postverticals lacking and other bristles occasionally missing or doubled. Body slightly darkened. Fertility of both males and females reduced, females more severely than males. Strength of sterilizing effect allele-dependent. Females generally sterile.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057757 NM_166951 RefSeq (Proteins) • NP_477105 NP_726829 DDBJ / EMBL / GenBank • AA390394 AA949467 AAF45822 AAG22402 AAK93191 AAN04260 AAN04261 AAN04262 AAN04263 AAN04264 AAN04265 AAN04266 AAN04267 AAN04268 AAN04269 AAN04270 AAN04271 AAN04272 AAN04273 AAN04274 AAN04275 AAN04276 AAN04277 AAN04278 AAN04279 AAN04280 AAN04281 AAN04282 AAN04283 AAN04284 AAN04285 AAN04286 AAN04287 AAN04288 AAN04289 AAN04290 AAN04291 AAN04292 AAN04293 AF365364 AF365365 AF365366 AF365367 AF365368 AF365369 AF365370 AF365371 AF365372 AF365373 AF365374 AF365375 AF365376 AF365377 AF365378 AF365379 AF365380 AF365381 AF365382 AF365383 AF365384 AF365385 AF365386 AF365387 AF365388 AF365389 AF365390 AF365391 AF365392 AF365393 AF365394 AF365396 AF365397 AF365398 AJ569035 AJ569036 AJ569037 AJ569038 AJ569039 AJ569040 AJ569041 AJ569042 AJ569043 AJ569044 AJ569045 AJ569046 AJ569047 AJ569048 AJ569049 AJ569050 AJ569051 AJ569052 AJ569053 AJ569054 AJ569055 AJ569056 AJ569057 AJ569058 AL021728 AW942970 AY051767 CAA16818 CAB55550 CL527800 CZ483823 Y13674 Entrez Gene - A searchable database of RefSeq genes. • 31268 UniProtKB/Swiss-Prot • O76906
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SANT domain, DNA binding (IPR001005)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57799 DroID - A comprehensive database of gene and protein interactions. • FBgn0000376 DRSC - Results from RNAi screens. • FBgn0000376 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000376 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2714-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000376 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31268 InParanoid A subset of ortholog calls from InParanoid. • AAEL014683-PA Aedes aegypti (mosquito) AGAP001029-PA Anopheles gambiae (mosquito) XP_001952351.1 Acyrthosiphon pisum (pea aphid) XP_001902870.1 Brugia malayi (roundworm nematode) BGIBMGA014363-PA Bombyx mori (silk worm) JA14183 Caenorhabditis japonica (nematode) CPIJ014021 Culex pipens (mosquito) RP39654 Caenorhabditis remanei (nematode) 206971 Capitella spl (polychaete worm) 326754 Daphnia pulex (daphnia) ENSECAP00000020840 Equus caballus (horse) ENSGACP00000017201 Gymnopilus aculeatus (mushroom) ENSGALP00000015195 Gallus gallus (chicken) 194326 Hypsipyla robusta (cedar shoot borer) ENSP00000380559 Homo sapiens (human) ISCW017333-PA Ixodes scapularis (deer tick) ENSMUSP00000073060 Mus musculus (house mouse) 243801 Nematostella vectensis (starlet anemone) XP_001605790.1 Nasonia vitripennis (wasp) ENSORLP00000014518 Oryzias latipes (japanese killifish) PHUM006811-PA Pediculus humanus (human body louse) ENSPPYP00000007878 Pongo pygmaeus (orangutan) ENSPTRP00000053805 Pan troglodytes (chimpanzee) ENSRNOP00000022050 Rattus norvegicus (norway rat) Smp_168340 Schistosoma mansoni (trematode parasite) 56673 Trichoplax adhaerens (metazoa) XP_973783.2 Tribolium castaneum (red flour beetle) ENSTNIP00000005216 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000008606 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043640 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/cramped1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31268 modMine - Data generated by the modENCODE project. • FBgn0000376 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17764 NV15647 LH20377 ISCW017333 FBgn0234411 FBgn0227361 FBgn0205687 FBgn0041270 FBgn0063998 JGI_V11_326754 FBgn0075461 FBgn0157404 FBgn0133734 FBgn0110818 FBgn0099477 CPIJ014021 BGIBMGA014363 ACYPI000215 GB30217 GB16357 GB15282 AGAP001029 AAEL014683 PHUM117620 GLEAN_07439
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG2714 (Klebes et al., 2005, Benos, 2000.12.13, Verstreken and Bellen, 2000.9.4, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2011.7.19) crm (Legube et al., 2006, Gibert and Schlötterer, 2007, Gibert et al., 2007, Buscaino et al., 2006, Vogel et al., 2009) EG:95B7.2 (Benos et al., 2001, Benos, 2000.12.13, ) l(1)3C1 (Gersh, 1967, ) l(1)3Ca   l(1)zw9 (Lin and Wolfner, 1989, Pastink et al., 1987, Paradi et al., 1983, Garcia-Bellido and Robbins, 1983, Thierry-Mieg, 1982, Lim and Snyder, 1974, Shannon et al., 1972, ) sa (Green, 1984, Sorsa et al., 1973, Rayle and Green, 1968, ) staP   swa (Fahmy and Fahmy, 1959, ) zw-9 (Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Liu and Lim, 1975) zw9 (Montgomery et al., 1991, Pastink et al., 1990, Goldberg et al., 1989, Schalet, 1986, Lefevre and Watkins, 1986, Robbins, 1983, Thierry-Mieg, 1982, Pelisson, 1981, Lefevre, 1981, Bingham, 1981, Judd et al., 1972, ) ZW-9 (Paradi et al., 1983)
Name Synonym	cramped (Vogel et al., 2009) sparse-arista   stubarista from P32   swollen-antenna (Fahmy and Fahmy, 1959, )
Secondary FlyBase IDs
References ( 82 )
Generate a list of	All references relating to this gene ( 82 )
List References by type	Research paper  ( 51 ) Supplementary material  ( 2 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Book  ( 2 )
Recent research papers ( 1 )
	Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. [FBrf0212864] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...